|
Name |
Accession |
Description |
Interval |
E-value |
| pheT |
PRK00629 |
phenylalanyl-tRNA synthetase subunit beta; Reviewed |
1-795 |
0e+00 |
|
phenylalanyl-tRNA synthetase subunit beta; Reviewed
Pssm-ID: 234804 [Multi-domain] Cd Length: 791 Bit Score: 1126.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 1 MKFSEKWLREWVNPAIDTQALSEQLSMAGLEVDGVEPAAAKFNGVVVGEVVECGQHPDADKLRVTKINVGgDELLDIVCG 80
Cdd:PRK00629 1 MKFSLSWLKEYVNPDISSEELAEALTMIGLEVEGVEDVAAGLSGVVVGKVLECEKHPNADKLRVCQVDVG-EEPLQIVCG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 81 APNCRLGIKVAVATVGAVLPGDFKIKKAKLRGQPSNGMLCAFVELGISEEGDGIMELPSDAPVGTDLRDYLGLDDNIIDV 160
Cdd:PRK00629 80 APNVRAGDKVPVALPGAVLPGGFKIKKAKLRGVESEGMLCSASELGLSDDHDGIIELPEDAPVGTDAREYLGLDDTVIEI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 161 DLTPNRGDCLGIKGLAREVGVLNSIDVNVLDIPAVTPTIDDKVSIELVNEDACPRYLGRVIKGINLDAETPLWMVEKLRR 240
Cdd:PRK00629 160 SLTPNRADCLSVRGIARELAALLGLPLKLPEIEPVPATIDDKLPVEIEDPDLCPRYAGRVIKGVKNIAPSPLWLQERLRA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 241 SGVRSIDPVVDVTNYVLLELGHPMHAFDLNAIEGGIKVRSANAGEELVLLDGNTAKLNDTTLVIADHNKALAIAGIFGGE 320
Cdd:PRK00629 240 AGIRPINNVVDITNYVMLELGQPLHAFDLDKIGGGIVVRRAKEGEKLTTLDGKERTLDPEDLVIADDKKPLALAGVMGGE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 321 QSGVTNKTSDILLESAFFNPVAIAGQARSYGLHTDASHRYERGVDFALQHDAMERATALLLEIVGGQAGPVVeaVAADKL 400
Cdd:PRK00629 320 DSEVTENTTNVLLESAYFDPVSIRKTARRLGLRTDASYRFERGVDPALTLLALERATALILELGGGEVVEGV--VDVYPL 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 401 PKVTEVRLRRARLDRVIGHHIEDAKVTDILTRLGLDV-KVENESWSADVPSYRFDIRIEEDLIEEVARVYGYNSIPNVAP 479
Cdd:PRK00629 398 PKEPTITLRLERINRLLGTEISDEEIVDILKRLGFEVtEVDGDGLTVTVPSWRFDIEIEEDLVEEVARIYGYDNIPSTPP 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 480 TAKLKMTTHNEATIALSKFRNTLVTRGYQEAITYSFVDPKAQAILHPECKAMVLPHPISIEMSAMRVSLMPGLLASVAYN 559
Cdd:PRK00629 478 VAALTMGGLTEAQRLLRRLRRALAALGYQEVITYSFVSPEDAKLFGLNPEPLLLLNPISEELSVMRTSLLPGLLEAVAYN 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 560 QNRQQPRIRLFEHGLKFISDESAENgvyQVPVIGGVITGLVNGEHWvEEKRNVDFYDLKGDVEALLAITNDITRFEIKAE 639
Cdd:PRK00629 558 LNRGNKDVALFEIGRVFLPDGDLPR---EPEHLAGVLTGNRVEESW-GGKRPVDFFDLKGDVEALLEALGLPEVEFVAEF 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 640 QSDGLHPGQSAVIYVDGKKVGFFGALHPQAQKSLDINNATFVFEIEMSAIE--KRNLPQAEGVSKFPSNRRDIAILVADS 717
Cdd:PRK00629 634 EAAALHPGRSAEIYLDGKVIGFIGELHPKVLKKLDLPGRTYVFELDLDALLeaARKLPKYKPISKFPAVRRDLALVVDED 713
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 743333892 718 VKSGDILSVIEKVGGNQLVDLNLFDVYKGKGIEPNYKSLAIALTLQAVDRTLEEKDINLVVDNVVAELAEQFNASLRD 795
Cdd:PRK00629 714 VPAADILKAIKKAGGKLLESVELFDVYEGKGIGEGKKSLAFRLTFQDPDRTLTDEEINAAMDKIVAALEEKFGAELRG 791
|
|
| PheT |
COG0072 |
Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; ... |
1-795 |
0e+00 |
|
Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Phenylalanyl-tRNA synthetase beta subunit is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439842 [Multi-domain] Cd Length: 793 Bit Score: 1097.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 1 MKFSEKWLREWVNPAIDTQALSEQLSMAGLEVDGVEPAAAKFNGVVVGEVVECGQHPDADKLRVTKINVGGDELLDIVCG 80
Cdd:COG0072 1 MKLSLLWLLLLVEEAALLEELLLLLTGEGLEEEEVEGAAAVVVGVVVVVVVVEEPHPDADDLVVVVVDVGGGEVLVVVCG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 81 APNCRLGIKVAVATVGAVLPGDFKIKKAKLRGQPSNGMLCAFVELGISEEGDGIMELPSDAPVGTDLRDYLGLDDNIIDV 160
Cdd:COG0072 81 AANVAVGVVVVAAPGGAVLPGGFKIKKAKIRGVESSGMLCSEEELGLGEDHDGIIVLPPDAPVGGDAREYLGLDDTVLEI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 161 DLTPNRGDCLGIKGLAREVGVLNSIDVNVLDI-PAVTPTIDDKVSIELVNEDACPRYLGRVIKGINLdAETPLWMVEKLR 239
Cdd:COG0072 161 DLTPNRADCLSVRGVARELAALLGAPLKLPAIePEVPPAIDDPIPVEIEDPEACPRYAGRVIRGVKV-GPSPLWMQERLR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 240 RSGVRSIDPVVDVTNYVLLELGHPMHAFDLNAIEGGIKVRSANAGEELVLLDGNTAKLNDTTLVIADHNKALAIAGIFGG 319
Cdd:COG0072 240 AAGIRPINNVVDITNYVMLELGQPLHAFDLDKLKGGIVVRRAREGEKLTTLDGKERTLDPDDLVIADDEGPLALAGVMGG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 320 EQSGVTNKTSDILLESAFFNPVAIAGQARSYGLHTDASHRYERGVDFALQHDAMERATALLLEIVGGQAGP-VVEAVaaD 398
Cdd:COG0072 320 EDSEVTEETTDVLLESAYFDPVSIRRTARRLGLHSDASYRFERGVDPALTVAALERATQLILEIAGGEVGPgIVDVY--P 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 399 KLPKVTEVRLRRARLDRVIGHHIEDAKVTDILTRLGLDVKVENESWSADVPSYRFDIRIEEDLIEEVARVYGYNSIPNVA 478
Cdd:COG0072 398 EPPEPKTITLRLARINRLLGVEIPAEEIEEILERLGFEVEEDGDGLTVTVPSWRFDIEIEADLIEEVARIYGYDNIPSTL 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 479 PTAKLKMTTHNEATIALSKFRNTLVTRGYQEAITYSFVDPKAQAILHPECKAMVLPHPISIEMSAMRVSLMPGLLASVAY 558
Cdd:COG0072 478 PRAPLAGGGLTEAQRLRRRVRRALAARGYQEVITYSFVSPEDADLFGLRREAVRLANPISEDLSVMRTSLLPGLLEAAAY 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 559 NQNRQQPRIRLFEHGLKFISDESAENGvyQVPVIGGVITGLVNGEHWVEEKRNVDFYDLKGDVEALLAITNdITRFEIKA 638
Cdd:COG0072 558 NLNRGQKDVRLFEIGRVFLPDEGEEPR--EPLHLAGVLTGNREPESWGGKARPVDFFDLKGDVEALLAALG-VPKLEFEA 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 639 EQSDGLHPGQSAVIYVDGKKVGFFGALHPQAQKSLDINNATFVFEIEMSAI--EKRNLPQAEGVSKFPSNRRDIAILVAD 716
Cdd:COG0072 635 AEHPALHPGRSAEILLGGKVIGFIGELHPKVLKALDLPGPVYVFELDLDALleLARKVPKYKPISKFPAVRRDLALVVDE 714
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 743333892 717 SVKSGDILSVIEKVGGNQLVDLNLFDVYKGKGIEPNYKSLAIALTLQAVDRTLEEKDINLVVDNVVAELAEQFNASLRD 795
Cdd:COG0072 715 DVPAADVLDAIRKAAGKLLEDVRLFDVYEGKGVPEGKKSLAFSLTLQDPDRTLTDEEIDAAMDKIVAALEKKFGAELRG 793
|
|
| pheT_bact |
TIGR00472 |
phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Every known example of ... |
1-794 |
0e+00 |
|
phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Every known example of the phenylalanyl-tRNA synthetase, except the monomeric form of mitochondrial, is an alpha 2 beta 2 heterotetramer. The beta subunits break into two subfamilies that are considerably different in sequence, length, and pattern of gaps. This model represents the subfamily that includes the beta subunit from Bacteria other than spirochetes, as well as a chloroplast-encoded form from Porphyra purpurea. The chloroplast-derived sequence is considerably shorter at the amino end. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273097 [Multi-domain] Cd Length: 797 Bit Score: 885.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 1 MKFSEKWLREWVNPA-IDTQALSEQLSMAGLEVDGVEPAAAKFNGVVVGEVVECGQHPDADKLRVTKINVGGDELLDIVC 79
Cdd:TIGR00472 1 MKISLKWLREYVPLSeIDNEEIAEALTSIGLEVEAVIPFSKPLKGVVVGKVLEVEPHPNADKLKVCKVDIGEKEMLQIVC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 80 GAPNCRLGIKVAVATVGAVLPGDFKIKKAKLRGQPSNGMLCAFVELGISEEGDGIMELPSDAPVGTDLRDYLGLDDNIID 159
Cdd:TIGR00472 81 GAPNVEAGKKVAVALPGAKLPNGLKIKKSKLRGVESEGMLCSESELGLDEKSDGIIVLDEDAPLGTDIAEYLGLDDDIIE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 160 VDLTPNRGDCLGIKGLAREVGVLNSIDV--NVLDIPAVTPTIDDKVSIELVNEDACPRYLGRVIKGINLDaETPLWMVEK 237
Cdd:TIGR00472 161 VSITPNRGDCLSILGIARELAALFDLNLetPVPFEPETTETIDEGFKIEIEDPEVCPFYLGRVIKGVKVK-PSPLWLKER 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 238 LRRSGVRSIDPVVDVTNYVLLELGHPMHAFDLNAIEGGIKVRSANAGEELVLLDGNTAKLNDTTLVIADHNKALAIAGIF 317
Cdd:TIGR00472 240 LRRSGIRPINNIVDITNYVMLELGQPLHAFDADKIEGNIVVRSAKEGESFTTLDGKERELKKGDLVIADDKKPLAIAGVM 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 318 GGEQSGVTNKTSDILLESAFFNPVAIAGQARSYGLHTDASHRYERGVDFALQHDAMERATALLLEIVGGQAGPVVeAVAA 397
Cdd:TIGR00472 320 GGKESGVTDTTTNIFLESAYFNPESIRKTARRLGISTDSSYRFERGVDPELTELALDRALNLILEIFGGEVISVV-SDNY 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 398 DKLPKVTEVRLRRARLDRVIGHHIEDAKVTDILTRLGLDVKVENESWSADVPSYRFDIRIEEDLIEEVARVYGYNSIPNV 477
Cdd:TIGR00472 399 KEKAKEKKISLRIKKLNKILGIELSDEEVRDILKRLGFKVEKQKDGWEVTVPSYRHDIEIEEDLIEEIARIYGYDNIPAE 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 478 APTAKLKMTTHNEATIALSKFRNTLVTRGYQEAITYSFVDP-KAQAILHPECKAMV-LPHPISIEMSAMRVSLMPGLLAS 555
Cdd:TIGR00472 479 PLSVSSKLNKNNENYLLLRKLRTLLVGLGLNEVITYSFVDPeKAEKFNFPKLENLVeIKNPLSNERSVLRTSLLPSLLEV 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 556 VAYNQNRQQPRIRLFEHGLKFISDESAENgvyQVPVIGGVITGLVNGEHWVEEKRNVDFYDLKGDVEALLAITN-DITRF 634
Cdd:TIGR00472 559 LAYNQNRKNKDVKIFEIGKVFAKDGEAVK---EQLRLAILISGEKNPSSWNHKEEKVDFYDLKGDVESLLELLGlSDDVY 635
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 635 EIKAEQSDGLHPGQSAVIYVDGKKVGFFGALHPQAQKSLDINNATFVFEIEMSAI--EKRNLPQAEGVSKFPSNRRDIAI 712
Cdd:TIGR00472 636 FKNTAENEELHPGQSATIYLKGKKIGFIGELHPEIAKKYDLKEPTFVFELDLDRLleSLKKVPKYRPISKFPAVTRDISF 715
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 713 LVADSVKSGDILSVIEKVGGNQLVDLNLFDVYKGKGIEPNYKSLAIALTLQAVDRTLEEKDINLVVDNVVAELAEQFNAS 792
Cdd:TIGR00472 716 LVPKDVPANEIIKLIKKSGLELLEEVELFDVYQGKNIGEGKKSLALRLVLRDKERTLTDEEINKIVEKVLNALKEKLGAE 795
|
..
gi 743333892 793 LR 794
Cdd:TIGR00472 796 LR 797
|
|
| B3_4 |
pfam03483 |
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ... |
212-385 |
1.28e-90 |
|
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.
Pssm-ID: 427327 [Multi-domain] Cd Length: 174 Bit Score: 282.13 E-value: 1.28e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 212 ACPRYLGRVIKGINLDAETPLWMVEKLRRSGVRSIDPVVDVTNYVLLELGHPMHAFDLNAIEGGIKVRSANAGEELVLLD 291
Cdd:pfam03483 1 ACPRYFGRVIRGVKKNRPSPEWLQRRLRRAGIRPINNVVDITNYVMLELGQPLHAFDLDKIAGDIVVRLAKGGEKFTTLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 292 GNTAKLNDTTLVIADHNKALAIAGIFGGEQSGVTNKTSDILLESAFFNPVAIAGQARSYGLHTDASHRYERGVDFALQHD 371
Cdd:pfam03483 81 GKERELDPGDLVIADDDGPVALAGIMGGEESEVTEDTTNIFLESAGFDPVAIRKTARRLGLRTDASYRFERGVDPELVEA 160
|
170
....*....|....
gi 743333892 372 AMERATALLLEIVG 385
Cdd:pfam03483 161 ALDRATALLLELCG 174
|
|
| B3_4 |
smart00873 |
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ... |
213-385 |
1.21e-72 |
|
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.
Pssm-ID: 214876 [Multi-domain] Cd Length: 174 Bit Score: 234.85 E-value: 1.21e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 213 CPRYLGRVIKGINLDAETPLWMVEKLRRSGVRSIDPVVDVTNYVLLELGHPMHAFDLNAIEGG-IKVRSANAGEELVLLD 291
Cdd:smart00873 1 CPRYLGRVIRGVKNTRPSPEWLQERLHRAGIRPINNVVDITNYVSLETGQPLHAFDLDKIKGKdIPLRRAKEGEKFETLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 292 GNTAKLNDTTLVIADHNKALAIAGIFGGEQSGVTNKTSDILLESAFFNPVAIAGQARSYGLHTDASHRYERGVDFALQHD 371
Cdd:smart00873 81 GKEYELDEGDLVIADDEGPLALAGVMGGEESEVTENTTVIFLEPAIFSPRTIRITARTLNLFTDASGRFERGVDPELVEL 160
|
170
....*....|....
gi 743333892 372 AMERATALLLEIVG 385
Cdd:smart00873 161 ALDRAAALLLEICG 174
|
|
| PheRS_beta_core |
cd00769 |
Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II ... |
490-689 |
4.85e-69 |
|
Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. PheRS is an alpha-2/ beta-2 tetramer. While the alpha chain contains a catalytic core domain, the beta chain has a non-catalytic core domain.
Pssm-ID: 238392 [Multi-domain] Cd Length: 198 Bit Score: 225.99 E-value: 4.85e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 490 EATIALSKFRNTLVTRGYQEAITYSFVDPK-AQAILHPECKAMVLPHPISIEMSAMRVSLMPGLLASVAYNQNRQQPRIR 568
Cdd:cd00769 1 PLQKLERKLRRLLAGLGFQEVITYSLTSPEeAELFDGGLDEAVELSNPLSEEYSVLRTSLLPGLLDALARNLNRKNKPLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 569 LFEHGLKFISDEsaeNGVYQVPVIGGVITGLVNGEHWVEEKRNVDFYDLKGDVEALLAITNDITRFEIKAEQSDGLHPGQ 648
Cdd:cd00769 81 LFEIGRVFLKDE---DGPEEEEHLAALLSGNREPESWQGKGRPVDFYDAKGILEALLRALGIIVEFELEELDADLFHPGR 157
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 743333892 649 SAVIYVDGKKVGFFGALHPQAQKSLDINNATFVFEIEMSAI 689
Cdd:cd00769 158 SAKIYVNGEVIGFIGELHPEVLKEFDLKEPVYAFELDLDAL 198
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| pheT |
PRK00629 |
phenylalanyl-tRNA synthetase subunit beta; Reviewed |
1-795 |
0e+00 |
|
phenylalanyl-tRNA synthetase subunit beta; Reviewed
Pssm-ID: 234804 [Multi-domain] Cd Length: 791 Bit Score: 1126.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 1 MKFSEKWLREWVNPAIDTQALSEQLSMAGLEVDGVEPAAAKFNGVVVGEVVECGQHPDADKLRVTKINVGgDELLDIVCG 80
Cdd:PRK00629 1 MKFSLSWLKEYVNPDISSEELAEALTMIGLEVEGVEDVAAGLSGVVVGKVLECEKHPNADKLRVCQVDVG-EEPLQIVCG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 81 APNCRLGIKVAVATVGAVLPGDFKIKKAKLRGQPSNGMLCAFVELGISEEGDGIMELPSDAPVGTDLRDYLGLDDNIIDV 160
Cdd:PRK00629 80 APNVRAGDKVPVALPGAVLPGGFKIKKAKLRGVESEGMLCSASELGLSDDHDGIIELPEDAPVGTDAREYLGLDDTVIEI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 161 DLTPNRGDCLGIKGLAREVGVLNSIDVNVLDIPAVTPTIDDKVSIELVNEDACPRYLGRVIKGINLDAETPLWMVEKLRR 240
Cdd:PRK00629 160 SLTPNRADCLSVRGIARELAALLGLPLKLPEIEPVPATIDDKLPVEIEDPDLCPRYAGRVIKGVKNIAPSPLWLQERLRA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 241 SGVRSIDPVVDVTNYVLLELGHPMHAFDLNAIEGGIKVRSANAGEELVLLDGNTAKLNDTTLVIADHNKALAIAGIFGGE 320
Cdd:PRK00629 240 AGIRPINNVVDITNYVMLELGQPLHAFDLDKIGGGIVVRRAKEGEKLTTLDGKERTLDPEDLVIADDKKPLALAGVMGGE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 321 QSGVTNKTSDILLESAFFNPVAIAGQARSYGLHTDASHRYERGVDFALQHDAMERATALLLEIVGGQAGPVVeaVAADKL 400
Cdd:PRK00629 320 DSEVTENTTNVLLESAYFDPVSIRKTARRLGLRTDASYRFERGVDPALTLLALERATALILELGGGEVVEGV--VDVYPL 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 401 PKVTEVRLRRARLDRVIGHHIEDAKVTDILTRLGLDV-KVENESWSADVPSYRFDIRIEEDLIEEVARVYGYNSIPNVAP 479
Cdd:PRK00629 398 PKEPTITLRLERINRLLGTEISDEEIVDILKRLGFEVtEVDGDGLTVTVPSWRFDIEIEEDLVEEVARIYGYDNIPSTPP 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 480 TAKLKMTTHNEATIALSKFRNTLVTRGYQEAITYSFVDPKAQAILHPECKAMVLPHPISIEMSAMRVSLMPGLLASVAYN 559
Cdd:PRK00629 478 VAALTMGGLTEAQRLLRRLRRALAALGYQEVITYSFVSPEDAKLFGLNPEPLLLLNPISEELSVMRTSLLPGLLEAVAYN 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 560 QNRQQPRIRLFEHGLKFISDESAENgvyQVPVIGGVITGLVNGEHWvEEKRNVDFYDLKGDVEALLAITNDITRFEIKAE 639
Cdd:PRK00629 558 LNRGNKDVALFEIGRVFLPDGDLPR---EPEHLAGVLTGNRVEESW-GGKRPVDFFDLKGDVEALLEALGLPEVEFVAEF 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 640 QSDGLHPGQSAVIYVDGKKVGFFGALHPQAQKSLDINNATFVFEIEMSAIE--KRNLPQAEGVSKFPSNRRDIAILVADS 717
Cdd:PRK00629 634 EAAALHPGRSAEIYLDGKVIGFIGELHPKVLKKLDLPGRTYVFELDLDALLeaARKLPKYKPISKFPAVRRDLALVVDED 713
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 743333892 718 VKSGDILSVIEKVGGNQLVDLNLFDVYKGKGIEPNYKSLAIALTLQAVDRTLEEKDINLVVDNVVAELAEQFNASLRD 795
Cdd:PRK00629 714 VPAADILKAIKKAGGKLLESVELFDVYEGKGIGEGKKSLAFRLTFQDPDRTLTDEEINAAMDKIVAALEEKFGAELRG 791
|
|
| PheT |
COG0072 |
Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; ... |
1-795 |
0e+00 |
|
Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Phenylalanyl-tRNA synthetase beta subunit is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439842 [Multi-domain] Cd Length: 793 Bit Score: 1097.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 1 MKFSEKWLREWVNPAIDTQALSEQLSMAGLEVDGVEPAAAKFNGVVVGEVVECGQHPDADKLRVTKINVGGDELLDIVCG 80
Cdd:COG0072 1 MKLSLLWLLLLVEEAALLEELLLLLTGEGLEEEEVEGAAAVVVGVVVVVVVVEEPHPDADDLVVVVVDVGGGEVLVVVCG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 81 APNCRLGIKVAVATVGAVLPGDFKIKKAKLRGQPSNGMLCAFVELGISEEGDGIMELPSDAPVGTDLRDYLGLDDNIIDV 160
Cdd:COG0072 81 AANVAVGVVVVAAPGGAVLPGGFKIKKAKIRGVESSGMLCSEEELGLGEDHDGIIVLPPDAPVGGDAREYLGLDDTVLEI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 161 DLTPNRGDCLGIKGLAREVGVLNSIDVNVLDI-PAVTPTIDDKVSIELVNEDACPRYLGRVIKGINLdAETPLWMVEKLR 239
Cdd:COG0072 161 DLTPNRADCLSVRGVARELAALLGAPLKLPAIePEVPPAIDDPIPVEIEDPEACPRYAGRVIRGVKV-GPSPLWMQERLR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 240 RSGVRSIDPVVDVTNYVLLELGHPMHAFDLNAIEGGIKVRSANAGEELVLLDGNTAKLNDTTLVIADHNKALAIAGIFGG 319
Cdd:COG0072 240 AAGIRPINNVVDITNYVMLELGQPLHAFDLDKLKGGIVVRRAREGEKLTTLDGKERTLDPDDLVIADDEGPLALAGVMGG 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 320 EQSGVTNKTSDILLESAFFNPVAIAGQARSYGLHTDASHRYERGVDFALQHDAMERATALLLEIVGGQAGP-VVEAVaaD 398
Cdd:COG0072 320 EDSEVTEETTDVLLESAYFDPVSIRRTARRLGLHSDASYRFERGVDPALTVAALERATQLILEIAGGEVGPgIVDVY--P 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 399 KLPKVTEVRLRRARLDRVIGHHIEDAKVTDILTRLGLDVKVENESWSADVPSYRFDIRIEEDLIEEVARVYGYNSIPNVA 478
Cdd:COG0072 398 EPPEPKTITLRLARINRLLGVEIPAEEIEEILERLGFEVEEDGDGLTVTVPSWRFDIEIEADLIEEVARIYGYDNIPSTL 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 479 PTAKLKMTTHNEATIALSKFRNTLVTRGYQEAITYSFVDPKAQAILHPECKAMVLPHPISIEMSAMRVSLMPGLLASVAY 558
Cdd:COG0072 478 PRAPLAGGGLTEAQRLRRRVRRALAARGYQEVITYSFVSPEDADLFGLRREAVRLANPISEDLSVMRTSLLPGLLEAAAY 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 559 NQNRQQPRIRLFEHGLKFISDESAENGvyQVPVIGGVITGLVNGEHWVEEKRNVDFYDLKGDVEALLAITNdITRFEIKA 638
Cdd:COG0072 558 NLNRGQKDVRLFEIGRVFLPDEGEEPR--EPLHLAGVLTGNREPESWGGKARPVDFFDLKGDVEALLAALG-VPKLEFEA 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 639 EQSDGLHPGQSAVIYVDGKKVGFFGALHPQAQKSLDINNATFVFEIEMSAI--EKRNLPQAEGVSKFPSNRRDIAILVAD 716
Cdd:COG0072 635 AEHPALHPGRSAEILLGGKVIGFIGELHPKVLKALDLPGPVYVFELDLDALleLARKVPKYKPISKFPAVRRDLALVVDE 714
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 743333892 717 SVKSGDILSVIEKVGGNQLVDLNLFDVYKGKGIEPNYKSLAIALTLQAVDRTLEEKDINLVVDNVVAELAEQFNASLRD 795
Cdd:COG0072 715 DVPAADVLDAIRKAAGKLLEDVRLFDVYEGKGVPEGKKSLAFSLTLQDPDRTLTDEEIDAAMDKIVAALEKKFGAELRG 793
|
|
| pheT_bact |
TIGR00472 |
phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Every known example of ... |
1-794 |
0e+00 |
|
phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Every known example of the phenylalanyl-tRNA synthetase, except the monomeric form of mitochondrial, is an alpha 2 beta 2 heterotetramer. The beta subunits break into two subfamilies that are considerably different in sequence, length, and pattern of gaps. This model represents the subfamily that includes the beta subunit from Bacteria other than spirochetes, as well as a chloroplast-encoded form from Porphyra purpurea. The chloroplast-derived sequence is considerably shorter at the amino end. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273097 [Multi-domain] Cd Length: 797 Bit Score: 885.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 1 MKFSEKWLREWVNPA-IDTQALSEQLSMAGLEVDGVEPAAAKFNGVVVGEVVECGQHPDADKLRVTKINVGGDELLDIVC 79
Cdd:TIGR00472 1 MKISLKWLREYVPLSeIDNEEIAEALTSIGLEVEAVIPFSKPLKGVVVGKVLEVEPHPNADKLKVCKVDIGEKEMLQIVC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 80 GAPNCRLGIKVAVATVGAVLPGDFKIKKAKLRGQPSNGMLCAFVELGISEEGDGIMELPSDAPVGTDLRDYLGLDDNIID 159
Cdd:TIGR00472 81 GAPNVEAGKKVAVALPGAKLPNGLKIKKSKLRGVESEGMLCSESELGLDEKSDGIIVLDEDAPLGTDIAEYLGLDDDIIE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 160 VDLTPNRGDCLGIKGLAREVGVLNSIDV--NVLDIPAVTPTIDDKVSIELVNEDACPRYLGRVIKGINLDaETPLWMVEK 237
Cdd:TIGR00472 161 VSITPNRGDCLSILGIARELAALFDLNLetPVPFEPETTETIDEGFKIEIEDPEVCPFYLGRVIKGVKVK-PSPLWLKER 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 238 LRRSGVRSIDPVVDVTNYVLLELGHPMHAFDLNAIEGGIKVRSANAGEELVLLDGNTAKLNDTTLVIADHNKALAIAGIF 317
Cdd:TIGR00472 240 LRRSGIRPINNIVDITNYVMLELGQPLHAFDADKIEGNIVVRSAKEGESFTTLDGKERELKKGDLVIADDKKPLAIAGVM 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 318 GGEQSGVTNKTSDILLESAFFNPVAIAGQARSYGLHTDASHRYERGVDFALQHDAMERATALLLEIVGGQAGPVVeAVAA 397
Cdd:TIGR00472 320 GGKESGVTDTTTNIFLESAYFNPESIRKTARRLGISTDSSYRFERGVDPELTELALDRALNLILEIFGGEVISVV-SDNY 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 398 DKLPKVTEVRLRRARLDRVIGHHIEDAKVTDILTRLGLDVKVENESWSADVPSYRFDIRIEEDLIEEVARVYGYNSIPNV 477
Cdd:TIGR00472 399 KEKAKEKKISLRIKKLNKILGIELSDEEVRDILKRLGFKVEKQKDGWEVTVPSYRHDIEIEEDLIEEIARIYGYDNIPAE 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 478 APTAKLKMTTHNEATIALSKFRNTLVTRGYQEAITYSFVDP-KAQAILHPECKAMV-LPHPISIEMSAMRVSLMPGLLAS 555
Cdd:TIGR00472 479 PLSVSSKLNKNNENYLLLRKLRTLLVGLGLNEVITYSFVDPeKAEKFNFPKLENLVeIKNPLSNERSVLRTSLLPSLLEV 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 556 VAYNQNRQQPRIRLFEHGLKFISDESAENgvyQVPVIGGVITGLVNGEHWVEEKRNVDFYDLKGDVEALLAITN-DITRF 634
Cdd:TIGR00472 559 LAYNQNRKNKDVKIFEIGKVFAKDGEAVK---EQLRLAILISGEKNPSSWNHKEEKVDFYDLKGDVESLLELLGlSDDVY 635
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 635 EIKAEQSDGLHPGQSAVIYVDGKKVGFFGALHPQAQKSLDINNATFVFEIEMSAI--EKRNLPQAEGVSKFPSNRRDIAI 712
Cdd:TIGR00472 636 FKNTAENEELHPGQSATIYLKGKKIGFIGELHPEIAKKYDLKEPTFVFELDLDRLleSLKKVPKYRPISKFPAVTRDISF 715
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 713 LVADSVKSGDILSVIEKVGGNQLVDLNLFDVYKGKGIEPNYKSLAIALTLQAVDRTLEEKDINLVVDNVVAELAEQFNAS 792
Cdd:TIGR00472 716 LVPKDVPANEIIKLIKKSGLELLEEVELFDVYQGKNIGEGKKSLALRLVLRDKERTLTDEEINKIVEKVLNALKEKLGAE 795
|
..
gi 743333892 793 LR 794
Cdd:TIGR00472 796 LR 797
|
|
| EMAP |
COG0073 |
tRNA-binding EMAP/Myf domain [Translation, ribosomal structure and biogenesis]; |
1-774 |
1.03e-153 |
|
tRNA-binding EMAP/Myf domain [Translation, ribosomal structure and biogenesis];
Pssm-ID: 439843 [Multi-domain] Cd Length: 773 Bit Score: 467.79 E-value: 1.03e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 1 MKFSEKWLREWVNPAIDTQALSEQLSMAGLEVDGVEPAAAkFNGVVVGEVVECGQHPDADKLRVTKINVGgDELLDIVCG 80
Cdd:COG0073 1 MKVSLSWLKEYVDLDLSPEELAEKLTMAGIEVEDFEKVGG-LDGLRVGKVLEAEPHPNADKLLVLQVDVG-EETRQIVCG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 81 APNCRLGIKVAVATVGAVLPGDFKIKKAKLRGQPSNGMLCAFVELGISEEGDGIMELPSDAPVGTDLRDYLGLDDNIIDV 160
Cdd:COG0073 79 APNVYAGDKVPEALVGAQVPGVVNLKPRKIRGVESEGMLCSAEELGLGEDHDGILELPEDAPPGDDAEYLLLLDDVIIEI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 161 DLTPNRGDCLGIKGLAREVGVLNsIDVNVLDIPAVTPTIDDKVSIELVNEDACPRYLGRVIKGINLDAETPLWMVEKLRR 240
Cdd:COG0073 159 LTTPNRDDLLSVGGAAREAAALG-GLLLKPPAPPVVEGTDDAVLVVVVDDDACDRYYGRVVRGVVNVVVPPPPWLRRLLR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 241 SGVRSIDPVVDVTNYVLLELGHPMHAFDLNAIEGGIKVRSANAGEELVLLDGNTAKLNDTTLVIADHNKALAIAGIFGGE 320
Cdd:COG0073 238 RGGRRRIINVVDINNVVLLLLGQPHHAFDDDDLGGGIVVRRRRAEELLLLLLGDTTLLLDDLLLIDDDDDALAAAGGGGG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 321 QSGVTNKTSDILLESAFFNPVAIAGQARSYGLHTDASHRYERGVDFALQHDAMERATALLLEIVGGQAGPVVEAVAADKL 400
Cdd:COG0073 318 GGGSSGSTTTTTLLLAAAAFFAAAGRRRRRRRLSSRSSRRRRREDDDDPRVAAAAAAAALLLIILGGGGGVAGGVVDEGL 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 401 PKVTEVRLRRAR-LDRVIGHHIEDAKVTDILTRLGLDVKVENESWSADVPSYRFDIRIEEDLIEEVARVYGYNSIPNVAP 479
Cdd:COG0073 398 PPPPPRIIRLRRrRRLLLLGIDIDEEELLLLLLLLGFEVEGEGESVVVPPPRRRDDVIEEDEEEEEARRYYYYDLPPPPP 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 480 TAKLKMTTHNEATIALSKFRNTLVTRGYQEAITYSFVDPKAQAILHPECKAMVLPHPISIEMSAMRVSLMPGLLASVAYN 559
Cdd:COG0073 478 PAPPAVPEPPAARRRLRRRRRLLLLLGLEEAVTYSSFSELLLALLLLFEAALLLLLPPSSLSSSLLLSLLLLLLLLVLLL 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 560 QNRQQPRIRLFEHGLKFISDESAENGVYQVPVIGGVITGLVNGEHWVEEKRNVDFYDLKGDVEALLAITNDITRFEIKAE 639
Cdd:COG0073 558 LRRRNRNRRLFEGGEVFFGFEGGGLELLLAELEAGGALLLGGGGGAALGLAADDADDLAGVLLLLALLLGLLALLALAAA 637
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 640 QSDGLHPGQSAVIYVDGKKVGFFGALHPQAQKSLDINNATFVFEIEMSAIEKRNLPQAEGVSKFPSNRRDIAILVADSVK 719
Cdd:COG0073 638 APAAAAPGAGGAGGLLLGGGGGLGGLLPVLLKLLLLLLLALLFEVLLDELLLPAAVLLALPLVARPLLRAIVVDVAAAVA 717
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*
gi 743333892 720 SGDILSVIEKVGGNQLVDLNLFDVYKGKGIEPNYKSLAIALTLQAVDRTLEEKDI 774
Cdd:COG0073 718 AALAAVAAALALVVALLAVVLLVVVVDVGVGKVLKKLLLSLDLEVTLLDLEELEL 772
|
|
| B3_4 |
pfam03483 |
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ... |
212-385 |
1.28e-90 |
|
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.
Pssm-ID: 427327 [Multi-domain] Cd Length: 174 Bit Score: 282.13 E-value: 1.28e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 212 ACPRYLGRVIKGINLDAETPLWMVEKLRRSGVRSIDPVVDVTNYVLLELGHPMHAFDLNAIEGGIKVRSANAGEELVLLD 291
Cdd:pfam03483 1 ACPRYFGRVIRGVKKNRPSPEWLQRRLRRAGIRPINNVVDITNYVMLELGQPLHAFDLDKIAGDIVVRLAKGGEKFTTLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 292 GNTAKLNDTTLVIADHNKALAIAGIFGGEQSGVTNKTSDILLESAFFNPVAIAGQARSYGLHTDASHRYERGVDFALQHD 371
Cdd:pfam03483 81 GKERELDPGDLVIADDDGPVALAGIMGGEESEVTEDTTNIFLESAGFDPVAIRKTARRLGLRTDASYRFERGVDPELVEA 160
|
170
....*....|....
gi 743333892 372 AMERATALLLEIVG 385
Cdd:pfam03483 161 ALDRATALLLELCG 174
|
|
| syfB |
CHL00192 |
phenylalanyl-tRNA synthetase beta chain; Provisional |
154-794 |
2.15e-87 |
|
phenylalanyl-tRNA synthetase beta chain; Provisional
Pssm-ID: 214391 [Multi-domain] Cd Length: 704 Bit Score: 291.22 E-value: 2.15e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 154 DDNIIDVDLTPNRGDCLGIKGLAREVGVLNSIDVNVLDIPAVTPTIDDKVSIELVNEDA---CPRYLGRVIKGINlDAET 230
Cdd:CHL00192 45 SDIILDISSTANRSDVLSIQGLSREISALFNSDPIKLKYYNPSISWFDKLKNLISNDSSklnCSMFIAVIIENIE-IKDS 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 231 PLWMVEKLRRSGVRSIDPVVDVTNYVLLELGHPMHAFDLNAIEG-----GIKVRSANAGE--ELVLLDGNTAKLNDTTLV 303
Cdd:CHL00192 124 PKWLQNRLSSSGFKSLNNLTDIQNYIMLETGQPIEIYDLDKIYSknttsSLALSSKFALQksSFIASNSKNIELENNILV 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 304 IADHNKALAIAGIFGGEQSGVTNKTSDILLESAFFNPVAIAGQARSYGLHTDASHRYERGVDFALQHDAMERATALLlei 383
Cdd:CHL00192 204 VQANNVIISIAGIISNEEIICDKNTKSILIEASIFDAAVIRKSSRKLGLRTDRSIRYEKSLKNDNLLEAYYRLVSLL--- 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 384 vgGQAGPVVEaVAADKLPKVTEVRLRRARLD-----RVIG--------HHIEDAKVTDILTRLGLDV--KVENESWSADV 448
Cdd:CHL00192 281 --RILNPKLK-CKFHFIYKKIKNSSRRIKLSykkikDILGpikintntRYLSPKEITNALKRLNFKItyDSLKLNWEVLI 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 449 PSYR-FDIRIEEDLIEEVARVYGYNSIPNVAPTAK-LKMTTHNEATIalSKFRNTLVTRGYQEAITYSFVdpKAQAILHP 526
Cdd:CHL00192 358 PSYRkDDIVREIDVIEEIARIYGFNNFLSKLPNIKfIGRLDIDYNTR--DKIRSYLRNLGLTELIHYSLV--KQESFSKN 433
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 527 ECKamvLPHPISIEMSAMRVSLMPGLLASVAYNQNRQQPRIRLFEHGLKFISDESAEngVYQVPVIGGVITGLVNGEHWV 606
Cdd:CHL00192 434 EIK---LKNPLIKDYSTLRSSLLPGLIEAVQENLKQGNSTLEGFEIGHVFNLDSSSI--IEETELAGGIFGGIDIRSSWS 508
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 607 EEKRNVDFYDLKGDVEALLAITNDITRFEIKA--EQSDGLHPGQSAVIYV-DGKKVGFFGALHPQAQKSLDINNATFVFE 683
Cdd:CHL00192 509 EKAQSLNWFEAKGIIENFFQKLNLPIYWKKYSdlDEKINFHPYCTSEIFLsNGQKIGIFGQLHPLLANKLNLNTEIYLFE 588
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 684 IEM----SAIEKRNLPQAEGVSKFPSNRRDIAILVADSVKSGDILSVIEKVGGNQLVDLNLFDVYKGKGIEPNYKSLAIA 759
Cdd:CHL00192 589 INLdilqYSIQQNNLISYQPYSSYPKIIRDLSFIIKKSISISKIKELIYQNGDNLLESITLFDYYKGKSIPNGHTSLGLR 668
|
650 660 670
....*....|....*....|....*....|....*
gi 743333892 760 LTLQAVDRTLEEKDINLVVDNVVAELAEQFNASLR 794
Cdd:CHL00192 669 LTFQSENKTLTNEEIDRIQQNLQKVLEKKLNAEIR 703
|
|
| tRNA_synthFbeta |
pfam17759 |
Phenylalanyl tRNA synthetase beta chain CLM domain; This domain corresponds to the catalytic ... |
474-686 |
7.50e-74 |
|
Phenylalanyl tRNA synthetase beta chain CLM domain; This domain corresponds to the catalytic like domain (CLM) in the beta chain of phe tRNA synthetase.
Pssm-ID: 465487 [Multi-domain] Cd Length: 214 Bit Score: 239.38 E-value: 7.50e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 474 IPNVAPTAKLKMTTHNEATIALSKFRNTLVTRGYQEAITYSFVDPKAQAIL---HPECKAMVLPHPISIEMSAMRVSLMP 550
Cdd:pfam17759 1 IPSTLPKGPTTGGGLTPEQKLRRRVRDLLAAAGFTEVITYSFTSPKDLDKLledDPRRKAVKLANPLSEELSVMRTSLLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 551 GLLASVAYNQNRQQPRIRLFEHGLKFISDESaENGVYQVPVIGGVITGLVNGEHWVEEKRNVDFYDLKGDVEALLAITNd 630
Cdd:pfam17759 81 GLLETLAYNLNRGNPDVRLFEIGRVFLPDEL-EELPREPRRLAGLLTGKRLPESWQGKARPVDFYDLKGIVEALLAALG- 158
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 743333892 631 ITRFEIKAEQSDGLHPGQSAVIYVDGKKVGFFGALHPQAQKSLDINNATFVFEIEM 686
Cdd:pfam17759 159 IDDYEFEAADHPALHPGRSAEILVGGKVIGFIGELHPEVAKNFDLPQPVYVFELDL 214
|
|
| B3_4 |
smart00873 |
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ... |
213-385 |
1.21e-72 |
|
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.
Pssm-ID: 214876 [Multi-domain] Cd Length: 174 Bit Score: 234.85 E-value: 1.21e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 213 CPRYLGRVIKGINLDAETPLWMVEKLRRSGVRSIDPVVDVTNYVLLELGHPMHAFDLNAIEGG-IKVRSANAGEELVLLD 291
Cdd:smart00873 1 CPRYLGRVIRGVKNTRPSPEWLQERLHRAGIRPINNVVDITNYVSLETGQPLHAFDLDKIKGKdIPLRRAKEGEKFETLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 292 GNTAKLNDTTLVIADHNKALAIAGIFGGEQSGVTNKTSDILLESAFFNPVAIAGQARSYGLHTDASHRYERGVDFALQHD 371
Cdd:smart00873 81 GKEYELDEGDLVIADDEGPLALAGVMGGEESEVTENTTVIFLEPAIFSPRTIRITARTLNLFTDASGRFERGVDPELVEL 160
|
170
....*....|....
gi 743333892 372 AMERATALLLEIVG 385
Cdd:smart00873 161 ALDRAAALLLEICG 174
|
|
| PheRS_beta_core |
cd00769 |
Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II ... |
490-689 |
4.85e-69 |
|
Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. PheRS is an alpha-2/ beta-2 tetramer. While the alpha chain contains a catalytic core domain, the beta chain has a non-catalytic core domain.
Pssm-ID: 238392 [Multi-domain] Cd Length: 198 Bit Score: 225.99 E-value: 4.85e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 490 EATIALSKFRNTLVTRGYQEAITYSFVDPK-AQAILHPECKAMVLPHPISIEMSAMRVSLMPGLLASVAYNQNRQQPRIR 568
Cdd:cd00769 1 PLQKLERKLRRLLAGLGFQEVITYSLTSPEeAELFDGGLDEAVELSNPLSEEYSVLRTSLLPGLLDALARNLNRKNKPLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 569 LFEHGLKFISDEsaeNGVYQVPVIGGVITGLVNGEHWVEEKRNVDFYDLKGDVEALLAITNDITRFEIKAEQSDGLHPGQ 648
Cdd:cd00769 81 LFEIGRVFLKDE---DGPEEEEHLAALLSGNREPESWQGKGRPVDFYDAKGILEALLRALGIIVEFELEELDADLFHPGR 157
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 743333892 649 SAVIYVDGKKVGFFGALHPQAQKSLDINNATFVFEIEMSAI 689
Cdd:cd00769 158 SAKIYVNGEVIGFIGELHPEVLKEFDLKEPVYAFELDLDAL 198
|
|
| tRNA_bind_bactPheRS |
cd02796 |
tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. ... |
53-147 |
4.58e-45 |
|
tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate the 2'OH of the terminal ribose of tRNA they belong functionally to class 1 aaRSs. This domain has general tRNA binding properties and is believed to direct tRNAphe to the active site of the enzyme.
Pssm-ID: 239196 [Multi-domain] Cd Length: 103 Bit Score: 156.90 E-value: 4.58e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 53 CGQHPDADKLRVTKINVGGDELLDIVCGAPNCRLGIKVAVATVGAVLPGDFKIKKAKLRGQPSNGMLCAFVELGISEEGD 132
Cdd:cd02796 9 VEPHPNADKLNVCKVDIGENKPLQIVCGAPNVRAGDKVVVALPGAVLPGGLKIKKRKLRGVESEGMLCSAKELGLGEDSD 88
|
90
....*....|....*
gi 743333892 133 GIMELPSDAPVGTDL 147
Cdd:cd02796 89 GIIELPEDAPVGTDI 103
|
|
| FDX-ACB |
smart00896 |
Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some ... |
701-794 |
8.32e-36 |
|
Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some phenylalanyl tRNA synthetases. The domain has a ferredoxin fold, consisting of an alpha+beta sandwich with anti-parallel beta-sheets (beta-alpha-beta x2).
Pssm-ID: 214893 [Multi-domain] Cd Length: 93 Bit Score: 130.24 E-value: 8.32e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 701 SKFPSNRRDIAILVADSVKSGDILSVIEKVGGNQLVDLNLFDVYKGkGIEPNYKSLAIALTLQAVDRTLEEKDINLVVDN 780
Cdd:smart00896 1 SKFPAVRRDLAFVVDEDVPAAELLDAIREAGGDLLEDVRLFDVYEG-GIPEGKKSLAYRLTYQSPDRTLTDEEVNAIHDK 79
|
90
....*....|....
gi 743333892 781 VVAELAEQFNASLR 794
Cdd:smart00896 80 IVAALEKKFGAELR 93
|
|
| FDX-ACB |
pfam03147 |
Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some ... |
701-794 |
3.91e-34 |
|
Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some phenylalanyl tRNA synthetases. The domain has a ferredoxin fold.
Pssm-ID: 460826 [Multi-domain] Cd Length: 94 Bit Score: 125.67 E-value: 3.91e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 701 SKFPSNRRDIAILVADSVKSGDILSVIEKVGGNQLVDLNLFDVYKGKGIEPNYKSLAIALTLQAVDRTLEEKDINLVVDN 780
Cdd:pfam03147 1 SKYPAVRRDLAFVVDEDVPAADILKAIREAGGELLESVELFDVYRGEKIPEGKKSLAFRLTFQSPERTLTDEEVNAIIEK 80
|
90
....*....|....
gi 743333892 781 VVAELAEQFNASLR 794
Cdd:pfam03147 81 IVEALEKKFGAELR 94
|
|
| tRNA_bindingDomain |
cd02153 |
The tRNA binding domain is also known as the Myf domain in literature. This domain is found in ... |
53-147 |
1.92e-28 |
|
The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human tyrosyl-tRNA synthetase(hTyrRS), Saccharomyces cerevisiae Arc1p, Thermus thermophilus CsaA, Aquifex aeolicus Trbp111, human p43 and human EMAP-II. PheRS, MetRS and hTyrRS aminoacylate their cognate tRNAs. Arc1p is a transactivator of yeast methionyl-tRNA and glutamyl-tRNA synthetases. The molecular chaperones Trbp111 and CsaA also contain this domain. CsaA has export related activities; Trbp111 is structure-specific recognizing the L-shape of the tRNA fold. This domain has general tRNA binding properties. In a subset of this family this domain has the added capability of a cytokine. For example the p43 component of the Human aminoacyl-tRNA synthetase complex is cleaved to release EMAP-II cytokine. EMAP-II has multiple activities during apoptosis, angiogenesis and inflammation and participates in malignant transformation. An EMAP-II-like cytokine is released from hTyrRS upon cleavage. The active cytokine heptapeptide locates to this domain. For homodimeric members of this group which include CsaA, Trbp111 and Escherichia coli MetRS this domain acts as a dimerization domain.
Pssm-ID: 239066 [Multi-domain] Cd Length: 99 Bit Score: 109.53 E-value: 1.92e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 53 CGQHPDADKLRVTKINVGGDELLDIVCGAPNC-----RLGIKVAVATVgavlpgdfkIKKAKLRGQPSNGMLCAFVELGI 127
Cdd:cd02153 9 AEPHPNADKLYVLKVDIGEEKPRQIVSGAANVyppeeLVGKKVVVAVN---------LKPKKLRGVESEGMLLSAEELGL 79
|
90 100
....*....|....*....|
gi 743333892 128 SEEGDGIMELPSDAPVGTDL 147
Cdd:cd02153 80 EEGSVGILELPEDAPVGDRI 99
|
|
| B5 |
smart00874 |
tRNA synthetase B5 domain; This domain is found in phenylalanine-tRNA synthetase beta subunits. |
404-471 |
3.17e-27 |
|
tRNA synthetase B5 domain; This domain is found in phenylalanine-tRNA synthetase beta subunits.
Pssm-ID: 197942 [Multi-domain] Cd Length: 68 Bit Score: 104.88 E-value: 3.17e-27
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 743333892 404 TEVRLRRARLDRVIGHHIEDAKVTDILTRLGLDVKVENESWSADVPSYRFDIRIEEDLIEEVARVYGY 471
Cdd:smart00874 1 RTITLRLERINRLLGLEILAEEIEEILKRLGFEVEVSGDTLEVTVPSYRFDILIEADLIEEVARIYGY 68
|
|
| B5 |
pfam03484 |
tRNA synthetase B5 domain; This domain is found in phenylalanine-tRNA synthetase beta subunits. |
406-471 |
4.61e-23 |
|
tRNA synthetase B5 domain; This domain is found in phenylalanine-tRNA synthetase beta subunits.
Pssm-ID: 460942 [Multi-domain] Cd Length: 67 Bit Score: 92.84 E-value: 4.61e-23
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 743333892 406 VRLRRARLDRVIGHHIEDAKVTDILTRLGLDVKVENE-SWSADVPSYRFDIRIEEDLIEEVARVYGY 471
Cdd:pfam03484 1 ITLRLDRINRLLGIDLSAEEIVEILERLGFEVEEEDGdTLTVTVPSYRPDILHEADLIEEVARIYGY 67
|
|
| PLN02265 |
PLN02265 |
probable phenylalanyl-tRNA synthetase beta chain |
417-688 |
7.65e-23 |
|
probable phenylalanyl-tRNA synthetase beta chain
Pssm-ID: 215149 [Multi-domain] Cd Length: 597 Bit Score: 103.61 E-value: 7.65e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 417 IGHHIEDAKVTDILTRLGLDVKVENESWSA---DVPSYRFDIRIEEDLIEEVARVYGYNSIPnvapTAKLKMTTHNeATI 493
Cdd:PLN02265 323 IGVSLDAEEVASLLNKMQLQAEQSSDDGCTirvSVPPTRSDILHPCDVAEDVAIAYGYNNIP----KRKPKSMTVG-KQQ 397
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 494 ALSKF----RNTLVTRGYQEAITYSFVDPKAQ-AILHPE---CKAMVLPHPISIEMSAMRVSLMPGLLASVAYNQNRQQP 565
Cdd:PLN02265 398 PLNQFsdllRAEVAMAGFTEVLTWILCSHKENfAMLNREddgNSAVIIGNPRSADFEVVRTSLLPGLLKTLGHNKDAPKP 477
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 566 rIRLFEHGLKFISDESAENG---------VYQVPVIG-GVITGLVNGEHWVEEKRNVDFYDLKGdveallaitnditrFE 635
Cdd:PLN02265 478 -IKLFEVSDVVLLDESKDVGarnsrrlaaLYCGTTSGfEVIHGLVDRIMEVLGIPFVEIGDNNG--------------YY 542
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 743333892 636 IKAEQSDGLHPGQSAVIYVDGKKVGFFGALHPQAQKSLDINNATFVFEIEMSA 688
Cdd:PLN02265 543 VEPSNEPEYFPGRQASIIYKGKHVGTFGIVHPEVLNNFDIPDPCSFLELDLEP 595
|
|
| tRNA_bind |
pfam01588 |
Putative tRNA binding domain; This domain is found in prokaryotic methionyl-tRNA synthetases, ... |
53-146 |
2.83e-21 |
|
Putative tRNA binding domain; This domain is found in prokaryotic methionyl-tRNA synthetases, prokaryotic phenylalanyl tRNA synthetases the yeast GU4 nucleic-binding protein (G4p1 or p42, ARC1), human tyrosyl-tRNA synthetase, and endothelial-monocyte activating polypeptide II. G4p1 binds specifically to tRNA form a complex with methionyl-tRNA synthetases. In human tyrosyl-tRNA synthetase this domain may direct tRNA to the active site of the enzyme. This domain may perform a common function in tRNA aminoacylation.
Pssm-ID: 396251 [Multi-domain] Cd Length: 96 Bit Score: 88.84 E-value: 2.83e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 53 CGQHPDADKLRVTKINVGGDELLDIVCGAPNCRLGIKVaVATVGAVLPgdfKIKKAKLRGQPSNGMLCAFVELgiSEEGD 132
Cdd:pfam01588 9 AERHPNADKLLVCKVDVGEEEPRQIVSGAVNVYPPEEL-VGRLVVVVA---NLKPAKLRGVESEGMILSAEEL--DGGSV 82
|
90
....*....|....
gi 743333892 133 GIMELPSDAPVGTD 146
Cdd:pfam01588 83 GLLEPPADVPPGTK 96
|
|
| B3/B4 |
COG3382 |
B3/B4 domain (DNA/RNA-binding domain of Phe-tRNA-synthetase) [General function prediction only] ... |
238-388 |
9.74e-10 |
|
B3/B4 domain (DNA/RNA-binding domain of Phe-tRNA-synthetase) [General function prediction only];
Pssm-ID: 442609 [Multi-domain] Cd Length: 233 Bit Score: 59.48 E-value: 9.74e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 238 LRRSGVRSIDPVVDVTNYVLLELGHPMHAFDLNAIEGGIKVRSANAGEELVLLDGNTAKLNDTTLVI-ADhnkalaIAGI 316
Cdd:COG3382 90 LKGGGLPRINPLVDLYNAVSLRYLLPIGGYDLDKIEGDLRLRLARGGESFLPIGGDEEEPPEPGEVVyAD------DEGV 163
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 743333892 317 FG-------GEQSGVTNKTSDILLesaffnpvaIAgqarsYGLHtdashryerGVDFALQHDAMERATALLLEIVGGQA 388
Cdd:COG3382 164 FCrrwpwrdSERTKVTEETKNALF---------II-----EGLP---------GVSAEDLEAALDELAELLERYLGGEV 219
|
|
| tRNA_bind_EMAP-II_like |
cd02799 |
tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of ... |
53-144 |
1.87e-08 |
|
tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae Arc1p, human p43 and EMAP2. CeMetRS and hTyrRS aminoacylate their cognate tRNAs. Arc1p is a transactivator of yeast methionyl-tRNA and glutamyl-tRNA synthetases. This domain has general tRNA binding properties. In a subset of this family this domain has the added capability of a cytokine. For example the p43 component of the Human aminoacyl-tRNA synthetase complex is cleaved to release EMAP-II cytokine. EMAP-II has multiple activities during apoptosis, angiogenesis and inflammation and participates in malignant transformation. A EMAP-II-like cytokine also is released from hTyrRS upon cleavage. The active cytokine heptapeptide locates to this domain.
Pssm-ID: 239198 [Multi-domain] Cd Length: 105 Bit Score: 52.62 E-value: 1.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 53 CGQHPDADKLRVTKINVGGDELLDIVCG-----APNCRLGIKVAVATvgavlpgdfKIKKAKLRGQPSNGM-LCAfvelg 126
Cdd:cd02799 16 VRKHPDADSLYVEEIDLGEEEPRTIVSGlvkfvPLEQMQNRLVVVLC---------NLKPRKMRGVKSQGMvLCA----- 81
|
90 100
....*....|....*....|.
gi 743333892 127 iSEEGDGIMEL---PSDAPVG 144
Cdd:cd02799 82 -SNADHEKVELlepPEGAKPG 101
|
|
| pheS_mito |
TIGR00469 |
phenylalanyl-tRNA synthetase, mitochondrial; Unlike all other known phenylalanyl-tRNA ... |
682-793 |
1.96e-04 |
|
phenylalanyl-tRNA synthetase, mitochondrial; Unlike all other known phenylalanyl-tRNA synthetases, the mitochondrial form demonstrated from yeast is monomeric. It is similar to but longer than the alpha subunit (PheS) of the alpha 2 beta 2 form found in Bacteria, Archaea, and eukaryotes, and shares the characteristic motifs of class II aminoacyl-tRNA ligases. This model models the experimental example from Saccharomyces cerevisiae (designated MSF1) and its orthologs from other eukaryotic species. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 129561 [Multi-domain] Cd Length: 460 Bit Score: 44.68 E-value: 1.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 682 FEIEMSAIEKRNLPQAEGVSKFPSNRRDIA------ILVADSVKSGDILSVIEKVGGNQLVDLNLFDVYKGKgiEPNYKS 755
Cdd:TIGR00469 345 FLRQFSEGDLHLIPKFKPISHHPGCFNDLAfwlpedIEDDAGFHENDFMDIIRNIAGDLVEQIKLVDKFKHP--KTGKKS 422
|
90 100 110
....*....|....*....|....*....|....*...
gi 743333892 756 LAIALTLQAVDRTLEEKDINLVVDNVVAELAEQFNASL 793
Cdd:TIGR00469 423 MCFRINYQHMDRNLTNAEVNEIHDMIASALVDEFNVEI 460
|
|
| class_II_aaRS-like_core |
cd00768 |
Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA ... |
495-672 |
1.17e-03 |
|
Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. These enzymes are usually homodimers. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. The substrate specificity of this reaction is further determined by additional domains. Intererestingly, this domain is also found is asparagine synthase A (AsnA), in the accessory subunit of mitochondrial polymerase gamma and in the bacterial ATP phosphoribosyltransferase regulatory subunit HisZ.
Pssm-ID: 238391 [Multi-domain] Cd Length: 211 Bit Score: 40.95 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 495 LSKFRNTLVTRGYQEAITYSFVDPKA--QAILHPecKAMVLPHPISIEMSAMRVSLMPGLlaSVAYNQNRQQPRIRLFEH 572
Cdd:cd00768 6 EQKLRRFMAELGFQEVETPIVEREPLleKAGHEP--KDLLPVGAENEEDLYLRPTLEPGL--VRLFVSHIRKLPLRLAEI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 743333892 573 GLKFISDesaengvyqvpvIGGVITGLVNGEHWVE-------EKRNVDFYDLKGDVEAL---LAITNDITRFEIKAEQSD 642
Cdd:cd00768 82 GPAFRNE------------GGRRGLRRVREFTQLEgevfgedGEEASEFEELIELTEELlraLGIKLDIVFVEKTPGEFS 149
|
170 180 190
....*....|....*....|....*....|....*.
gi 743333892 643 GLHPGQSAVIYVD-----GKKVGFFGALHP-QAQKS 672
Cdd:cd00768 150 PGGAGPGFEIEVDhpegrGLEIGSGGYRQDeQARAA 185
|
|
| |
