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Conserved domains on  [gi|767073357|gb|KJF94888|]
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ATPase [Photobacterium leiognathi]

Protein Classification

sensor histidine kinase( domain architecture ID 11428264)

sensor histidine kinase is part of a two-component regulatory system and functions as a protein kinase that phosphorylates a target protein in response to a signal

EC:  2.7.13.3
Gene Ontology:  GO:0004673|GO:0007165|GO:0005524|GO:0000160|GO:0016020|GO:0000155
PubMed:  11489844|18076326|10966457|11406410|12372152|8029829

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
115-433 2.02e-51

Signal transduction histidine kinase [Signal transduction mechanisms];


:

Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 176.25  E-value: 2.02e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 115 LERVLDFPDNKQLIIGINPKLMHAYRDSMIPVLVTGIVVPVILMLAGALLFAISILKKLERVNHGMNRVILGEKGVKLPV 194
Cdd:COG0642    3 LLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 195 SANDDEFDVLTIHLNFLIEQVEKKEESLKELSVGMAHDLRTPIARMKLRLEDLLTKDTAPFTKDLEACHDDLEVLLGMFN 274
Cdd:COG0642   83 LLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETILRSADRLLRLIN 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 275 GMLEIANINSGKHKIDKQWVDLSTVCQDVVEFLLPISDEKQQVLSFR-EDEPYKLQGEPSLLFRAIYNVVENAIKYTPEQ 353
Cdd:COG0642  163 DLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDlPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEG 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 354 GNIEVVVDHFGVVVI----DNGLGVSDEDKGRIKEPMYRADKSRTHQGFGLGLSLVEAVMKSHGGDLAF-SDNNPGLRTR 428
Cdd:COG0642  243 GTVTVSVRREGDRVRisveDTGPGIPPEDLERIFEPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTIEVeSEPGKGTTFT 322


                 ....*
gi 767073357 429 LYFPL 433
Cdd:COG0642  323 VTLPL 327
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
115-433 2.02e-51

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 176.25  E-value: 2.02e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 115 LERVLDFPDNKQLIIGINPKLMHAYRDSMIPVLVTGIVVPVILMLAGALLFAISILKKLERVNHGMNRVILGEKGVKLPV 194
Cdd:COG0642    3 LLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 195 SANDDEFDVLTIHLNFLIEQVEKKEESLKELSVGMAHDLRTPIARMKLRLEDLLTKDTAPFTKDLEACHDDLEVLLGMFN 274
Cdd:COG0642   83 LLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETILRSADRLLRLIN 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 275 GMLEIANINSGKHKIDKQWVDLSTVCQDVVEFLLPISDEKQQVLSFR-EDEPYKLQGEPSLLFRAIYNVVENAIKYTPEQ 353
Cdd:COG0642  163 DLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDlPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEG 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 354 GNIEVVVDHFGVVVI----DNGLGVSDEDKGRIKEPMYRADKSRTHQGFGLGLSLVEAVMKSHGGDLAF-SDNNPGLRTR 428
Cdd:COG0642  243 GTVTVSVRREGDRVRisveDTGPGIPPEDLERIFEPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTIEVeSEPGKGTTFT 322


                 ....*
gi 767073357 429 LYFPL 433
Cdd:COG0642  323 VTLPL 327
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 137-432 1.35e-28

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 117.10  E-value: 1.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357  137 HAYRDSMIPVLVTGIVVPVILM-LAGALLFAISiLKKLERVNHGMNRVILGEKGVKLPVSANDDEFDVLTIHLNFLIEQV 215
Cdd:TIGR01386 156 THLLDALRKWLILIAVLLVLLTaLLGWWITRLG-LEPLRRLSAVAARISPESLDQRLDPSRAPAELRELAQSFNAMLGRL 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357  216 EKKEESLKELSVGMAHDLRTPIARMKLRLEDLLTKD-TAPFTKD-LEACHDDLEVLLGMFNGMLEIANINSGKHKIDKQW 293
Cdd:TIGR01386 235 EDAFQRLSQFSADLAHELRTPLTNLLGQTQVALSQPrTGEEYREvLESNLEELERLSRMVSDMLFLARADNGQLALERVR 314

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357  294 VDLSTVCQDVVEFLLPISDEKQQVLSFREDEpyKLQGEPSLLFRAIYNVVENAIKYTPEQGNIE---VVVDHFGVVVIDN 370
Cdd:TIGR01386 315 LDLAAELAKVAEYFEPLAEERGVRIRVEGEG--LVRGDPQMFRRAISNLLSNALRHTPDGGTITvriERRSDEVRVSVSN 392

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767073357  371 -GLGVSDEDKGRIKEPMYRADKSRTH--QGFGLGLSLVEAVMKSHGGDlAFSDNNPG-LRTRLYFP 432
Cdd:TIGR01386 393 pGPGIPPEHLSRLFDRFYRVDPARSNsgEGTGLGLAIVRSIMEAHGGR-ASAESPDGkTRFILRFP 457
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 322-431 1.59e-24

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 97.48  E-value: 1.59e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 322 EDEPYKLQGEPSLLFRAIYNVVENAIKYTPEQGNIEVVVDHFGVVVI---DNGLGVSDEDKGRIKEPMYRADKsRTHQGF 398
Cdd:cd16940    1 SAADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAVIrveDNGPGIDEEELEALFERFYRSDG-QNYGGS 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767073357 399 GLGLSLVEAVMKSHGGDLAFSDN-NPGLRTRLYF 431
Cdd:cd16940   80 GLGLSIVKRIVELHGGQIFLGNAqGGGLEAWVRL 113
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 330-434 6.27e-21

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 87.32  E-value: 6.27e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357   330 GEPSLLFRAIYNVVENAIKYTPEQGNIEVVVDHFGVVVI----DNGLGVSDEDKGRIKEPMYRADK-SRTHQGFGLGLSL 404
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEitveDNGPGIPPEDLEKIFEPFFRTDKrSRKIGGTGLGLSI 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 767073357   405 VEAVMKSHGGDLAF-SDNNPGLRTRLYFPLK 434
Cdd:smart00387  81 VKKLVELHGGEISVeSEPGGGTTFTITLPLE 111
PRK09303 PRK09303
histidine kinase;
211-414 2.07e-18

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 86.54  E-value: 2.07e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 211 LIEQVEKKEESLKELsvgmAHDLRTP-----IA--RMKLRLEDLLTKDTAPFTKDL-EACHDDLEVLLGMFNGMLEIANI 282
Cdd:PRK09303 144 LLEQLKFKDRVLAML----AHDLRTPltaasLAleTLELGQIDEDTELKPALIEQLqDQARRQLEEIERLITDLLEVGRT 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 283 NSGKHKIDKQWVDLSTVCQDVVEFLLPISDEKQQvlSFREDEPYKLQ---GEPSLLFRAIYNVVENAIKYTPEQGNIEVV 359
Cdd:PRK09303 220 RWEALRFNPQKLDLGSLCQEVILELEKRWLAKSL--EIQTDIPSDLPsvyADQERIRQVLLNLLDNAIKYTPEGGTITLS 297

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 360 VDHFGVVVI-----DNGLGVSDEDKGRIKEPMYRADKSRTHQGFGLGLSLVEAVMKSHGG 414
Cdd:PRK09303 298 MLHRTTQKVqvsicDTGPGIPEEEQERIFEDRVRLPRDEGTEGYGIGLSVCRRIVRVHYG 357
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 330-435 6.07e-18

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 78.95  E-value: 6.07e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357  330 GEPSLLFRAIYNVVENAIKYTPEQGNIEVVVDHFGVVVI---DNGLGVSDEDKGRIKEPMYRADKsRTHQGFGLGLSLVE 406
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGELTLtveDNGIGIPPEDLPRIFEPFSTADK-RGGGGTGLGLSIVR 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 767073357  407 AVMKSHGGDLAF-SDNNPGLRTRLYFPLKP 435
Cdd:pfam02518  80 KLVELLGGTITVeSEPGGGTTVTLTLPLAQ 109
 
Name Accession Description Interval E-value
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
115-433 2.02e-51

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 176.25  E-value: 2.02e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 115 LERVLDFPDNKQLIIGINPKLMHAYRDSMIPVLVTGIVVPVILMLAGALLFAISILKKLERVNHGMNRVILGEKGVKLPV 194
Cdd:COG0642    3 LLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 195 SANDDEFDVLTIHLNFLIEQVEKKEESLKELSVGMAHDLRTPIARMKLRLEDLLTKDTAPFTKDLEACHDDLEVLLGMFN 274
Cdd:COG0642   83 LLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETILRSADRLLRLIN 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 275 GMLEIANINSGKHKIDKQWVDLSTVCQDVVEFLLPISDEKQQVLSFR-EDEPYKLQGEPSLLFRAIYNVVENAIKYTPEQ 353
Cdd:COG0642  163 DLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDlPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEG 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 354 GNIEVVVDHFGVVVI----DNGLGVSDEDKGRIKEPMYRADKSRTHQGFGLGLSLVEAVMKSHGGDLAF-SDNNPGLRTR 428
Cdd:COG0642  243 GTVTVSVRREGDRVRisveDTGPGIPPEDLERIFEPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTIEVeSEPGKGTTFT 322


                 ....*
gi 767073357 429 LYFPL 433
Cdd:COG0642  323 VTLPL 327
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
85-436 4.45e-45

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 161.26  E-value: 4.45e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357  85 FEYRITSSINTDTSITYPAVFSQTRLKSTKLERVLDFPDNKQLIIGINPKLMHAYRDSMIPVLVTGIVVPVILMLAGALL 164
Cdd:COG5002   28 LLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLL 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 165 FAISILKKLERVNHGMNRVILGEKGVKLPVSANDDEFDVLTIHLNFLIEQVEKKEESLKELSVGMAHDLRTPIARMKLRL 244
Cdd:COG5002  108 LALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 245 EDLL---TKDTAPFTKDLEACHDDLEVLLGMFNGMLEIANINSGKHKIDKQWVDLSTVCQDVVEFLLPISDEKQQVLSFR 321
Cdd:COG5002  188 ELLLdgaADDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELD 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 322 -EDEPYKLQGEPSLLFRAIYNVVENAIKYTPEQGNIEVVVDHFGVVVI----DNGLGVSDEDKGRIKEPMYRADKSRTHQ 396
Cdd:COG5002  268 lPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREEDDQVRisvrDTGIGIPEEDLPRIFERFYRVDKSRSRE 347

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 767073357 397 --GFGLGLSLVEAVMKSHGGDL-AFSDNNPGLRTRLYFPLKPQ 436
Cdd:COG5002  348 tgGTGLGLAIVKHIVEAHGGRIwVESEPGKGTTFTITLPLARE 390
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
212-436 1.93e-44

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 155.06  E-value: 1.93e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 212 IEQVEKKEESLKELSVGMAHDLRTPIARMKLRLEDLLTK---DTAPFTKDLEACHDDLEVLLGMFNGMLEIANINSGKHK 288
Cdd:COG2205    6 LEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEedlSPEERRELLEIIRESAERLLRLIEDLLDLSRLESGKLS 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 289 IDKQWVDLSTVCQDVVEFLLPISDEKQQVLSFR-EDEPYKLQGEPSLLFRAIYNVVENAIKYTPEQGNIEVVVDHFGVVV 367
Cdd:COG2205   86 LELEPVDLAELLEEAVEELRPLAEEKGIRLELDlPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGV 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767073357 368 ----IDNGLGVSDEDKGRIKEPMYRADKSRTHQGFGLGLSLVEAVMKSHGGDLAF-SDNNPGLRTRLYFPLKPQ 436
Cdd:COG2205  166 risvSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVeSEPGGGTTFTVTLPLAES 239
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 137-432 1.35e-28

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 117.10  E-value: 1.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357  137 HAYRDSMIPVLVTGIVVPVILM-LAGALLFAISiLKKLERVNHGMNRVILGEKGVKLPVSANDDEFDVLTIHLNFLIEQV 215
Cdd:TIGR01386 156 THLLDALRKWLILIAVLLVLLTaLLGWWITRLG-LEPLRRLSAVAARISPESLDQRLDPSRAPAELRELAQSFNAMLGRL 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357  216 EKKEESLKELSVGMAHDLRTPIARMKLRLEDLLTKD-TAPFTKD-LEACHDDLEVLLGMFNGMLEIANINSGKHKIDKQW 293
Cdd:TIGR01386 235 EDAFQRLSQFSADLAHELRTPLTNLLGQTQVALSQPrTGEEYREvLESNLEELERLSRMVSDMLFLARADNGQLALERVR 314

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357  294 VDLSTVCQDVVEFLLPISDEKQQVLSFREDEpyKLQGEPSLLFRAIYNVVENAIKYTPEQGNIE---VVVDHFGVVVIDN 370
Cdd:TIGR01386 315 LDLAAELAKVAEYFEPLAEERGVRIRVEGEG--LVRGDPQMFRRAISNLLSNALRHTPDGGTITvriERRSDEVRVSVSN 392

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767073357  371 -GLGVSDEDKGRIKEPMYRADKSRTH--QGFGLGLSLVEAVMKSHGGDlAFSDNNPG-LRTRLYFP 432
Cdd:TIGR01386 393 pGPGIPPEHLSRLFDRFYRVDPARSNsgEGTGLGLAIVRSIMEAHGGR-ASAESPDGkTRFILRFP 457
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 322-431 1.59e-24

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 97.48  E-value: 1.59e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 322 EDEPYKLQGEPSLLFRAIYNVVENAIKYTPEQGNIEVVVDHFGVVVI---DNGLGVSDEDKGRIKEPMYRADKsRTHQGF 398
Cdd:cd16940    1 SAADIQVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAVIrveDNGPGIDEEELEALFERFYRSDG-QNYGGS 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767073357 399 GLGLSLVEAVMKSHGGDLAFSDN-NPGLRTRLYF 431
Cdd:cd16940   80 GLGLSIVKRIVELHGGQIFLGNAqGGGLEAWVRL 113
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 216-437 5.72e-23

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 100.42  E-value: 5.72e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 216 EKKEESLKELSVGMAHDLRTPIA-------RMKLRLEDLLTKDTAPFTKDLEACHDDLEVLLGMFNGMLEIANInsgkHK 288
Cdd:COG5000  195 AERLAAWGELARRIAHEIKNPLTpiqlsaeRLRRKLADKLEEDREDLERALDTIIRQVDRLKRIVDEFLDFARL----PE 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 289 IDKQWVDLSTVCQDVVEFLLPISDEKQQVLSFR-EDEPYKLQGEPSLLFRAIYNVVENAIKYTPEQGNIEVVVDHFGVVV 367
Cdd:COG5000  271 PQLEPVDLNELLREVLALYEPALKEKDIRLELDlDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRV 350

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767073357 368 ----IDNGLGVSDEDKGRIKEPMYradksrTH--QGFGLGLSLVEAVMKSHGGDLAFSDNNP-GLRTRLYFPLKPQQ 437
Cdd:COG5000  351 rievSDNGPGIPEEVLERIFEPFF------TTkpKGTGLGLAIVKKIVEEHGGTIELESRPGgGTTFTIRLPLAEEA 421
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 335-431 9.83e-22

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 89.58  E-value: 9.83e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 335 LFRAIYNVVENAIKYTPEQGNIEVVVDHFGVVVI----DNGLGVSDEDKGRIKEPMYRADKSRTHQGFGLGLSLVEAVMK 410
Cdd:cd00075    1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVleveDNGPGIPEEDLERIFERFYRGDKSREGGGTGLGLAIVRRIVE 80

                         90       100
                 ....*....|....*....|..
gi 767073357 411 SHGGDL-AFSDNNPGLRTRLYF 431
Cdd:cd00075   81 AHGGRItVESEPGGGTTFTVTL 102
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 330-434 6.27e-21

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 87.32  E-value: 6.27e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357   330 GEPSLLFRAIYNVVENAIKYTPEQGNIEVVVDHFGVVVI----DNGLGVSDEDKGRIKEPMYRADK-SRTHQGFGLGLSL 404
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEitveDNGPGIPPEDLEKIFEPFFRTDKrSRKIGGTGLGLSI 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 767073357   405 VEAVMKSHGGDLAF-SDNNPGLRTRLYFPLK 434
Cdd:smart00387  81 VKKLVELHGGEISVeSEPGGGTTFTITLPLE 111
PRK09303 PRK09303
histidine kinase;
211-414 2.07e-18

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 86.54  E-value: 2.07e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 211 LIEQVEKKEESLKELsvgmAHDLRTP-----IA--RMKLRLEDLLTKDTAPFTKDL-EACHDDLEVLLGMFNGMLEIANI 282
Cdd:PRK09303 144 LLEQLKFKDRVLAML----AHDLRTPltaasLAleTLELGQIDEDTELKPALIEQLqDQARRQLEEIERLITDLLEVGRT 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 283 NSGKHKIDKQWVDLSTVCQDVVEFLLPISDEKQQvlSFREDEPYKLQ---GEPSLLFRAIYNVVENAIKYTPEQGNIEVV 359
Cdd:PRK09303 220 RWEALRFNPQKLDLGSLCQEVILELEKRWLAKSL--EIQTDIPSDLPsvyADQERIRQVLLNLLDNAIKYTPEGGTITLS 297

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 360 VDHFGVVVI-----DNGLGVSDEDKGRIKEPMYRADKSRTHQGFGLGLSLVEAVMKSHGG 414
Cdd:PRK09303 298 MLHRTTQKVqvsicDTGPGIPEEEQERIFEDRVRLPRDEGTEGYGIGLSVCRRIVRVHYG 357
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 330-435 6.07e-18

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 78.95  E-value: 6.07e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357  330 GEPSLLFRAIYNVVENAIKYTPEQGNIEVVVDHFGVVVI---DNGLGVSDEDKGRIKEPMYRADKsRTHQGFGLGLSLVE 406
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGELTLtveDNGIGIPPEDLPRIFEPFSTADK-RGGGGTGLGLSIVR 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 767073357  407 AVMKSHGGDLAF-SDNNPGLRTRLYFPLKP 435
Cdd:pfam02518  80 KLVELLGGTITVeSEPGGGTTVTLTLPLAQ 109
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 335-433 2.10e-17

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 77.37  E-value: 2.10e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 335 LFRAIYNVVENAIKYTPEQG--NIEVVVDHFGVVVIDNGLGVSDEDKGRIKEPMYRADKSRTHQ--GFGLGLSLVEAVMK 410
Cdd:cd16949    1 LARALENVLRNALRYSPSKIllDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDREsgGTGLGLAIAERAIE 80

                         90       100
                 ....*....|....*....|....
gi 767073357 411 SHGGDLAFSDNNP-GLRTRLYFPL 433
Cdd:cd16949   81 QHGGKIKASNRKPgGLRVRIWLPA 104
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 45-438 2.19e-17

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 84.45  E-value: 2.19e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357  45 QNQLEQDLNNEVSLFERMLDKGDYQAVIEAVDEHDKLDNAFEYRITSSINTDTSITYPAVFSQTRLKSTKLERVLDFPDN 124
Cdd:COG4251  107 LLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLL 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 125 KQLIIGINPKLMHAYRDSMIPVLVTGIVVPVILMLAGALLFAISILKKLERVnhGMNRVILGEKGVKLPVSANDDEFDVL 204
Cdd:COG4251  187 VLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLL--LLLILLLLLLILVLELLELRLELEEL 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 205 TIHLNFLIEQVEKKEESLKELSVGMAHDLRTPIaRMKLRLEDLLTKDTAPftKDLEACHDDLEVLLG-------MFNGML 277
Cdd:COG4251  265 EEELEERTAELERSNEELEQFAYVASHDLREPL-RKISGFSQLLEEDYGD--KLDEEGREYLERIRDaaermqaLIDDLL 341

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 278 EIANInsGKHKIDKQWVDLSTVCQDVVEFLLPISDEKQQVLSFrEDEPyKLQGEPSLLFRAIYNVVENAIKYTP--EQGN 355
Cdd:COG4251  342 AYSRV--GRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIEV-GPLP-TVRGDPTLLRQVFQNLISNAIKYSRpgEPPR 417

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 356 IEVVVDHFGVVVI----DNGLGVSDEDKGRIKEPMYRADKSRTHQGFGLGLSLVEAVMKSHGGDLAFsDNNPGLRTRLYF 431
Cdd:COG4251  418 IEIGAEREGGEWVfsvrDNGIGIDPEYAEKIFEIFQRLHSRDEYEGTGIGLAIVKKIVERHGGRIWV-ESEPGEGATFYF 496


                 ....*..
gi 767073357 432 PLKPQQN 438
Cdd:COG4251  497 TLPKAPA 503
PRK10337 PRK10337
sensor protein QseC; Provisional
 139-424 2.62e-16

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 80.85  E-value: 2.62e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 139 YRDSMIPVLVTGIVVP-------VILMLAGALLFAISILKKLERVNHGMNrvilGEKGVKLPVSANDDEFDVLTIHLNFL 211
Cdd:PRK10337 151 YREDMALAIVAGQLIPwlvalpiMLIILMVLLGRELAPLKKLALALRMRD----PDSETPLNATGVPSEVRPLVEALNQL 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 212 IEQVEKKEESLKELSVGMAHDLRTPIARMKLRLE--DLLTKDTAPFTKDLEACHDDLEVLLGMFNGMLEIANINSGKHKI 289
Cdd:PRK10337 227 FARTHAMMVRERRFTSDAAHELRSPLAALKVQTEvaQLSDDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQ 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 290 DKQWVDLSTVCQDVVEFLLPISDEKQQVLSFR-EDEPYKLQGEPSLLFRAIYNVVENAIKYTPEQGNIEVVVDHFGVVVI 368
Cdd:PRK10337 307 DVAEIPLEDLLQSAVMDIYHTAQQAGIDVRLTlNAHPVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARNFTVR 386

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767073357 369 DNGLGVSDEDKGRIKEPMYR---ADKSrthqGFGLGLSLVEAVMKSHGGDLAFsDNNPG 424
Cdd:PRK10337 387 DNGPGVTPEALARIGERFYRppgQEAT----GSGLGLSIVRRIAKLHGMNVSF-GNAPE 440
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
200-432 3.29e-16

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 80.59  E-value: 3.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 200 EFDVLTIHLNFLIEQVEKKEESLKELSVGMAHDLRTPIARMKLRLEDLLTKDTAPftKDLE-ACHDDLEV---LLGMFNG 275
Cdd:PRK09835 240 ELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQ--KELEdVLYSNLEEltrMAKMVSD 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 276 MLEIANINSGKHKIDKQWVDLSTVCQDVVEFLLPISDEKQQVLSFrEDEPYKLQGEPSLLFRAIYNVVENAIKYTPEQGN 355
Cdd:PRK09835 318 MLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRF-VGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEA 396

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 356 IE---VVVDHFGVVVIDN-GLGVSDEDKGRIKEPMYRADKSRTH--QGFGLGLSLVEAVMKSHGGDLAFSDNNPGLRTRL 429
Cdd:PRK09835 397 ITvrcQEVDHQVQLVVENpGTPIAPEHLPRLFDRFYRVDPSRQRkgEGSGIGLAIVKSIVVAHKGTVAVTSDARGTRFVI 476


                 ...
gi 767073357 430 YFP 432
Cdd:PRK09835 477 SLP 479
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
229-427 9.52e-16

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 79.78  E-value: 9.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357  229 MAHDLRTPIARMKLRLEdLLTKDTAPFTKDLEA---CHDDLEVLLGMFNGMLEIANINSGKHKIDKQWVDLSTVCQDVVE 305
Cdd:PRK09959  719 MSHEIRTPISSIMGFLE-LLSGSGLSKEQRVEAislAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIPTLVQNTCH 797

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357  306 FLLPISDEKQQVLSFREDEP--YKLQGEPSLLFRAIYNVVENAIKYTPEQG--------NIEVVVDHFGVVVIDNGLGVS 375
Cdd:PRK09959  798 SFGAIAASKSIALSCSSTFPdhYLVKIDPQAFKQVLSNLLSNALKFTTEGAvkittslgHIDDNHAVIKMTIMDSGSGLS 877

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767073357  376 DEDKGRIKEPMYRADKSRTHQGFGLGLSLVEAVMKSHGGDLAFsDNNPGLRT 427
Cdd:PRK09959  878 QEEQQQLFKRYSQTSAGRQQTGSGLGLMICKELIKNMQGDLSL-ESHPGIGT 928
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
155-440 1.47e-15

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 78.52  E-value: 1.47e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 155 VILMLAGALLFAISILKKLERVNHGMNRVILGEKGVKLPVSaNDDEFDVLTIHLNFLIEQVEKKEESLKELSVGMAHDLR 234
Cdd:PRK10549 174 TLLAALATFLLARGLLAPVKRLVEGTHKLAAGDFTTRVTPT-SRDELGRLAQDFNQLASTLEKNEQMRRDFMADISHELR 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 235 TPIARMKLRLE---DLLTKDTAPFTKDLEAchdDLEVLLGMFNGMLEIANINSGKHKIDKQWVDLSTVCQDVVEFLLPIS 311
Cdd:PRK10549 253 TPLAVLRGELEaiqDGVRKFTPESVASLQA---EVGTLTKLVDDLHQLSLSDEGALAYRKTPVDLVPLLEVAGGAFRERF 329

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 312 DEKQQVLSFREDEPYKLQGEPSLLFRAIYNVVENAIKYTPEQGNIEVVVDHFGVVVI----DNGLGVSDEDKGRIKEPMY 387
Cdd:PRK10549 330 ASRGLTLQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRltfaDSAPGVSDEQLQKLFERFY 409

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767073357 388 RADKSRTHQ--GFGLGLSLVEAVMKSHGGDLaFSDNNP--GLRTRLYFPLKPQQNRQ 440
Cdd:PRK10549 410 RTEGSRNRAsgGSGLGLAICLNIVEAHNGRI-IAAHSPfgGVSITVELPLERDLQRE 465
envZ PRK09467
osmolarity sensor protein; Provisional
 225-435 1.77e-15

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 78.03  E-value: 1.77e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 225 LSVGMAHDLRTPIARMKLRLE-----DLLTKDTapFTKDLEAChddlevllgmfNGMLE--IANINSGKhKIDKQWVDLS 297
Cdd:PRK09467 232 LMAGVSHDLRTPLTRIRLATEmmseeDGYLAES--INKDIEEC-----------NAIIEqfIDYLRTGQ-EMPMEMADLN 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 298 TVCQDVVeflLPISDEKQQVLSFREDEPYKLQGEPSLLFRAIYNVVENAIKYTPEQGNIEVVVDHFGVVVI--DNGLGVS 375
Cdd:PRK09467 298 ALLGEVI---AAESGYEREIETALQPGPIEVPMNPIAIKRALANLVVNAARYGNGWIKVSSGTEGKRAWFQveDDGPGIP 374

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767073357 376 DEDKGRIKEPMYRADKSRTHQGFGLGLSLVEAVMKSHGGDLAFSdNNP--GLRTRLYFPLKP 435
Cdd:PRK09467 375 PEQLKHLFQPFTRGDSARGSSGTGLGLAIVKRIVDQHNGKVELG-NSEegGLSARAWLPLTT 435
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
144-433 3.78e-15

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 77.28  E-value: 3.78e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 144 IPVLVTGIVVPVILMLAGallfaiSILKKLERVNHGMNRVILG--------EKGVKlpvsanddEFDVLTIHLNFLIEQV 215
Cdd:PRK09470 171 LLLVTMLVSTPLLLWLAW------SLAKPARKLKNAADEVAQGnlrqhpelETGPQ--------EFRQAGASFNQMVTAL 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 216 EKKEESLKELSVGMAHDLRTPIARMKLRLEdLLTK---DTAPFTK-DLEAchddlEVLLGMFNGMLEIANiNSGKHKIDK 291
Cdd:PRK09470 237 ERMMTSQQRLLSDISHELRTPLTRLQLATA-LLRRrqgESKELERiETEA-----QRLDSMINDLLVLSR-NQQKNHLER 309

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 292 QWVDLSTVCQDVVE---FllpisdEKQQ---VLSFRED-EPYKLQGEPSLLFRAIYNVVENAIKYTPEQgnIEVVVDHFG 364
Cdd:PRK09470 310 ETFKANSLWSEVLEdakF------EAEQmgkSLTVSAPpGPWPINGNPNALASALENIVRNALRYSHTK--IEVAFSVDK 381

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767073357 365 VVVI----DNGLGVSDEDKGRIKEPMYRADKSRTHQ--GFGLGLSLVEAVMKSHGGDLAFSDnNP--GLRTRLYFPL 433
Cdd:PRK09470 382 DGLTitvdDDGPGVPEEEREQIFRPFYRVDEARDREsgGTGLGLAIVENAIQQHRGWVKAED-SPlgGLRLTIWLPL 457
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
230-438 5.15e-15

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 76.16  E-value: 5.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 230 AHDLRTPIARMKLRLEdLLTK----DTAPFTKDLEACHDDLEVLLgmfngMLEIA--NINSGKHkidkQWVDLStvcQDV 303
Cdd:PRK10755 145 AHELRTPLAGIRLHLE-LLEKqhhiDVAPLIARLDQMMHTVEQLL-----QLARAgqSFSSGHY----QTVKLL---EDV 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 304 VeflLPISDE-------KQQVLSFREDEP-YKLQGEPSLLFRAIYNVVENAIKYTPEQGNI----EVVVDHFGVVVIDNG 371
Cdd:PRK10755 212 I---LPSQDElsemleqRQQTLLLPESAAdITVQGDATLLRLLLRNLVENAHRYSPEGSTItiklSQEDGGAVLAVEDEG 288

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767073357 372 LGVSDEDKGRIKEPMYRADkSRtHQGFGLGLSLVEAVMKSHGGDLAFSDNN--PGLRTRLYFPLKPQQN 438
Cdd:PRK10755 289 PGIDESKCGELSKAFVRMD-SR-YGGIGLGLSIVSRITQLHHGQFFLQNRQerSGTRAWVWLPKAQNVA 355
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
220-440 9.12e-15

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 75.27  E-value: 9.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 220 ESLKELSVGMAHDLRTPIARMKLRLEdLLTKDTAPftkdlEACHDDLEVLLGmfngmlEIANIN---------SGKHKID 290
Cdd:COG3852  133 AAVGELAAGLAHEIRNPLTGIRGAAQ-LLERELPD-----DELREYTQLIIE------EADRLNnlvdrllsfSRPRPPE 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 291 KQWVDLSTVCQDVVEFLLP-ISDEKQQVLSFREDEPyKLQGEPSLLFRAIYNVVENAIKYTPEQGNI------EVVVDHF 363
Cdd:COG3852  201 REPVNLHEVLERVLELLRAeAPKNIRIVRDYDPSLP-EVLGDPDQLIQVLLNLVRNAAEAMPEGGTItirtrvERQVTLG 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 364 GVVV--------IDNGLGVSDEDKGRIKEPMY--RAdksrthQGFGLGLSLVEAVMKSHGGDLAFsDNNPGLRT--RLYF 431
Cdd:COG3852  280 GLRPrlyvrievIDNGPGIPEEILDRIFEPFFttKE------KGTGLGLAIVQKIVEQHGGTIEV-ESEPGKGTtfRIYL 352


                 ....*....
gi 767073357 432 PLKPQQNRQ 440
Cdd:COG3852  353 PLEQAEEEP 361
PRK10604 PRK10604
sensor protein RstB; Provisional
 221-439 2.84e-14

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 74.25  E-value: 2.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 221 SLKELSVGMAHDLRTPIARMKLRLE--DLLTKDtapftkDLEACHDDLEVLLGMFNGMLEIANINSGKHKIDKQWVDLST 298
Cdd:PRK10604 211 SKKQLIDGIAHELRTPLVRLRYRLEmsDNLSAA------ESQALNRDIGQLEALIEELLTYARLDRPQNELHLSEPDLPA 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 299 VCQDVVEFLLPISDEKQQVLSFREDEPYkLQGEPSLLFRAIYNVVENAIKYTPEQGNIEVVVDHFGVVVI--DNGLGVSD 376
Cdd:PRK10604 285 WLSTHLADIQAVTPEKTVRLDTPHQGDY-GALDMRLMERVLDNLLNNALRYAHSRVRVSLLLDGNQACLIveDDGPGIPP 363

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767073357 377 EDKGRIKEPMYRADKSRTHQ--GFGLGLSLVEAVMKSHGGDLAFsDNNP--GLRTRLYFPLKPQQNR 439
Cdd:PRK10604 364 EERERVFEPFVRLDPSRDRAtgGCGLGLAIVHSIALAMGGSVNC-DESElgGARFSFSWPVWHNLPQ 429
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 276-435 8.83e-14

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 72.95  E-value: 8.83e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 276 MLEIANINSGKHKIDKQWVDLSTVCQDVVEFLLPISDEKQqvLSFRED-EPYKLQGEPSLLFRAIYNVVENAIKYTPEQG 354
Cdd:PRK11100 311 LLELARLEQRQELEVLEPVALAALLEELVEAREAQAAAKG--ITLRLRpDDARVLGDPFLLRQALGNLLDNAIDFSPEGG 388

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 355 NI----EVVVDHFGVVVIDNGLGVSDEDKGRIKEPMY---RADKSRthQGFGLGLSLVEAVMKSHGGDLAFsDNNP--GL 425
Cdd:PRK11100 389 TItlsaEVDGEQVALSVEDQGPGIPDYALPRIFERFYslpRPANGR--KSTGLGLAFVREVARLHGGEVTL-RNRPegGV 465

                        170
                 ....*....|
gi 767073357 426 RTRLYFPLKP 435
Cdd:PRK11100 466 LATLTLPRHF 475
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 334-424 1.78e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 66.33  E-value: 1.78e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 334 LLFRAIYNVVENAIKYTPEQGN----IEVVVDHFGVVVIDNGLGVSDEDKGRIKEPMYRADKSRTHQG-FGLGLSLVEAV 408
Cdd:cd16975    4 LLSRALINIISNACQYAPEGGTvsisIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGhYGMGLYIAKNL 83

                         90
                 ....*....|....*.
gi 767073357 409 MKSHGGDLAFSDNNPG 424
Cdd:cd16975   84 VEKHGGSLIIENSQKG 99
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 220-434 3.68e-13

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 70.60  E-value: 3.68e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 220 ESLKELSVGMAHDLRTPIA-------RMKLRLEDLLTKDTAPftKDLEACHDDLEVLLGMFNGMLEIaninSGKHKIDKQ 292
Cdd:COG4191  140 AALGELAAGIAHEINNPLAailgnaeLLRRRLEDEPDPEELR--EALERILEGAERAAEIVRSLRAF----SRRDEEERE 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 293 WVDLSTVCQDVVEFLLPISDEKQQVLSFR-EDEPYKLQGEPSLLFRAIYNVVENAIKYTPEQGN------IEVVVDHFGV 365
Cdd:COG4191  214 PVDLNELIDEALELLRPRLKARGIEVELDlPPDLPPVLGDPGQLEQVLLNLLINAIDAMEEGEGgritisTRREGDYVVI 293

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767073357 366 VVIDNGLGVSDEDKGRIKEPMYradksrT----HQGFGLGLSLVEAVMKSHGGDLAFsDNNPGLRT--RLYFPLK 434
Cdd:COG4191  294 SVRDNGPGIPPEVLERIFEPFF------TtkpvGKGTGLGLSISYGIVEKHGGRIEV-ESEPGGGTtfTITLPLA 361
PRK10490 PRK10490
sensor protein KdpD; Provisional
 220-435 3.86e-13

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 71.61  E-value: 3.86e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 220 ESLKE-LSVGMAHDLRTPIARMKLRLEdLLTKDTA----PFTKDLEACHDDLEVLLGMFNGMLEIANINSGKHKIDKQWV 294
Cdd:PRK10490 661 EQLRNaLLAALSHDLRTPLTVLFGQAE-ILTLDLAsegsPHARQASEIRQQVLNTTRLVNNLLDMARIQSGGFNLRKEWL 739

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 295 DLSTVCQDVVEFLLPISDEKQQVLSFREDEPYkLQGEPSLLFRAIYNVVENAIKYTPEQGNI----EVVVDHFGVVVIDN 370
Cdd:PRK10490 740 TLEEVVGSALQMLEPGLSGHPINLSLPEPLTL-IHVDGPLFERVLINLLENAVKYAGAQAEIgidaHVEGERLQLDVWDN 818

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767073357 371 GLGVSDEDKGRIKEPMYRADKSRTHQGFGLGLSLVEAVMKSHGGDLaFSDNNP--GLRTRLYFPLKP 435
Cdd:PRK10490 819 GPGIPPGQEQLIFDKFARGNKESAIPGVGLGLAICRAIVEVHGGTI-WAENRPegGACFRVTLPLET 884
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 211-442 4.31e-13

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 70.77  E-value: 4.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 211 LIEQVEKKEE--SLKELSVGMAHDLRTPIARMK----LrLEDLLTKDTAPFTKDLEACHDDLEVLLGMFngmLEIANINS 284
Cdd:COG5809  257 LEELLRKSEKlsVVGELAAGIAHEIRNPLTSLKgfiqL-LKDTIDEEQKTYLDIMLSELDRIESIISEF---LVLAKPQA 332

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 285 GKHKIdkqwVDLSTVCQDVVEFLLP--ISDEKQQVLSFREDEPYkLQGEPSLLFRAIYNVVENAIKYTPEQGNIEVVVDH 362
Cdd:COG5809  333 IKYEP----KDLNTLIEEVIPLLQPqaLLKNVQIELELEDDIPD-ILGDENQLKQVFINLLKNAIEAMPEGGNITIETKA 407

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 363 FGVVVI-----DNGLGVSDEDKGRIKEPMYradkSRTHQGFGLGLSLVEAVMKSHGGDL-AFSDNNPGLRTRLYFPLKPQ 436
Cdd:COG5809  408 EDDDKVvisvtDEGCGIPEERLKKLGEPFY----TTKEKGTGLGLMVSYKIIEEHGGKItVESEVGKGTTFSITLPIKLS 483


                 ....*.
gi 767073357 437 QNRQSE 442
Cdd:COG5809  484 EQVSMN 489
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
231-436 6.63e-13

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 70.04  E-value: 6.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 231 HDLRTPIARMKLRLEdlLTKDT----APFTKDLEACHDDLEVLLGMFNGMLEIANINSGKHKIDKQWVDLSTVCQDVVEF 306
Cdd:PRK11006 213 HELRTPLTVLQGYLE--MMQDQplegALREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDVPMMLRVLERE 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 307 LLPISDEKQQvLSFREDEPYKLQGEPSLLFRAIYNVVENAIKYTPEQGNIE----VVVDHFGVVVIDNGLGVSDEDKGRI 382
Cdd:PRK11006 291 AQTLSQGKHT-ITFEVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITvrwqRVPQGAEFSVEDNGPGIAPEHIPRL 369

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767073357 383 KEPMYRADKSRTHQ--GFGLGLSLVEAVMKSHGGDLAFSdNNPGLRTRLYFPLKPQ 436
Cdd:PRK11006 370 TERFYRVDKARSRQtgGSGLGLAIVKHALSHHDSRLEIE-SEVGKGTRFSFVLPER 424
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 335-437 1.38e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 61.06  E-value: 1.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 335 LFRAIYNVVENAIKYTPEQGNI----EVVVDHFGVVVIDNGLGVSDEDKGRIKEPMYRADKSRTHQ--GFGLGLSLVEAV 408
Cdd:cd16952    1 LRSAFSNLVSNAVKYTPPSDTItvrwSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNtgGTGLGLAIVKHV 80

                         90       100
                 ....*....|....*....|....*....
gi 767073357 409 MKSHGGDLAFSdNNPGLRTRLYFPLKPQQ 437
Cdd:cd16952   81 MSRHDARLLIA-SELGKGSRFTCLFPSSR 108
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 335-433 1.45e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 60.91  E-value: 1.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 335 LFRAIYNVVENAIKYTPEQGNIEVVVDHFGVVVI--DNGLGVSDEDKGRIKEPMYRADKSRTHQ--GFGLGLSLVEAVMK 410
Cdd:cd16939    1 MARALDNLLRNALRYAHRTVRIALLVSGGRLTLIveDDGPGIPAAARERVFEPFVRLDPSRDRAtgGFGLGLAIVHRVAL 80

                         90       100
                 ....*....|....*....|....
gi 767073357 411 SHGGDLAFSDNN-PGLRTRLYFPL 433
Cdd:cd16939   81 WHGGHVECDDSElGGACFRLTWPR 104
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 331-432 1.97e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 60.55  E-value: 1.97e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 331 EPSLLFRAIYNVVENAIKYTPEQGNIE----VVVDHFGVVVIDNGLGVSDEDKGRIKEPMYRADKSRTHQ--GFGLGLSL 404
Cdd:cd16946    1 DRDRLQQLFVNLLENSLRYTDTGGKLRiraaQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRAsgGSGLGLAI 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 767073357 405 VEAVMKSHGGDLAFsDNNP--GLRTRLYFP 432
Cdd:cd16946   81 CHNIALAHGGTISA-EHSPlgGLRLVLTLP 109
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 337-432 1.02e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 58.23  E-value: 1.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 337 RAIYNVVENAIKYtpeqGNIEVVVDHFGVVVI------DNGLGVSDEDKGRIKEPMYRADKSRTHQGFGLGLSLVEAVMK 410
Cdd:cd16950    3 RVLSNLVDNALRY----GGGWVEVSSDGEGNRtriqvlDNGPGIAPEEVDELFQPFYRGDNARGTSGTGLGLAIVQRISD 78

                         90       100
                 ....*....|....*....|...
gi 767073357 411 SHGGDLAFSDNNP-GLRTRLYFP 432
Cdd:cd16950   79 AHGGSLTLANRAGgGLCARIELP 101
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 335-424 5.79e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 56.24  E-value: 5.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 335 LFRAIYNVVENAIKYTPEQGNIEVVVDHF----GVVVIDNGLGVSDEDKGRIKEPMYRADKSRTHQGFGLGLSLVEAVMK 410
Cdd:cd16923    1 LQRVFSNLLSNAIKYSPENTRIYITSFLTddvvNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEGAGLGLSIAKAIIE 80

                         90
                 ....*....|....
gi 767073357 411 SHGGDLAFSDNNPG 424
Cdd:cd16923   81 LHGGSASAEYDDNH 94
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 341-434 1.32e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 55.19  E-value: 1.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 341 NVVENAIKYTPEqGNI---------EVVVDHFGVVVIDNGLGVSDEDKGRIKEPMYRADKS--RTHQGFGLGLSLVEAVM 409
Cdd:cd16922    7 NLLGNAIKFTEE-GEVtlrvsleeeEEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSSttRKYGGTGLGLAISKKLV 85

                         90       100
                 ....*....|....*....|....*
gi 767073357 410 KSHGGDLAFSdNNPGLRTRLYFPLK 434
Cdd:cd16922   86 ELMGGDISVE-SEPGQGSTFTFTLP 109
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 331-416 6.85e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 53.23  E-value: 6.85e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 331 EPSLLFRAIYNVVENAIKYTPEQGNI----EVVVDHFGVVVIDNGLGVSDEDKGRIKEPMYRADKSRTHQ-GFGLGLSLV 405
Cdd:cd16945    1 DPFLLRQAINNLLDNAIDFSPEGGLIalqlEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSGQkSTGLGLAFV 80

                         90
                 ....*....|.
gi 767073357 406 EAVMKSHGGDL 416
Cdd:cd16945   81 QEVAQLHGGRI 91
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
211-439 2.10e-08

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 56.51  E-value: 2.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 211 LIEQVEKKEE--SLKELSVGMAHDLRTPIARMKLRLEDLLTKDTAPFT-KDLEACHDDLEVLLGMFNGMLEIANINsgKH 287
Cdd:PRK11360 377 LQRRVARQERlaALGELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSqEYLSVVLREVDRLNKVIDQLLEFSRPR--ES 454

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 288 KIDKqwVDLSTVCQDVVEFLLPI--SDEKQQVLSFREDEPyKLQGEPSLLFRAIYNVVENAIKYTPEQGNIEVVVDHFGV 365
Cdd:PRK11360 455 QWQP--VSLNALVEEVLQLFQTAgvQARVDFETELDNELP-PIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSD 531

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 366 VVI-----DNGLGVSDEDKGRIKEPMYradkSRTHQGFGLGLSLVEAVMKSHGGDLaFSDNNPGLRT--RLYFPLKPQQN 438
Cdd:PRK11360 532 GQVavsieDNGCGIDPELLKKIFDPFF----TTKAKGTGLGLALSQRIINAHGGDI-EVESEPGVGTtfTLYLPINPQGN 606


                 .
gi 767073357 439 R 439
Cdd:PRK11360 607 Q 607
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
211-437 2.77e-08

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 55.56  E-value: 2.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 211 LIEQVEKKEE--SLKELSVGMAHDLRTPIARMKlrleDLLTKDTAPFTKDLEAcHDDLEVLLG-------MFNGMLEIan 281
Cdd:PRK10364 224 LQDEMKRKEKlvALGHLAAGVAHEIRNPLSSIK----GLAKYFAERAPAGGEA-HQLAQVMAKeadrlnrVVSELLEL-- 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 282 inSGKHKIDKQWVDLSTVCQDVVEFLLPISDEKQQVLSFREDEPYKL-QGEPSLLFRAIYNVVENAIKYTPEQGNIEVVV 360
Cdd:PRK10364 297 --VKPTHLALQAVDLNDLINHSLQLVSQDANSREIQLRFTANDTLPEiQADPDRLTQVLLNLYLNAIQAIGQHGVISVTA 374

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 361 DHFGVVVI----DNGLGVSDEDKGRIKEPmYRADKSrthQGFGLGLSLVEAVMKSHGGDL-AFSDNNPGLRTRLYFPLKP 435
Cdd:PRK10364 375 SESGAGVKisvtDSGKGIAADQLEAIFTP-YFTTKA---EGTGLGLAVVHNIVEQHGGTIqVASQEGKGATFTLWLPVNI 450


                 ..
gi 767073357 436 QQ 437
Cdd:PRK10364 451 TR 452
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 214-434 3.64e-08

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 55.68  E-value: 3.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 214 QVEKKEESLKELSVGMAHDLRTPIARMKLRLEDLLTKDTAPFTKD-LEACHDDLEVLLGMFNGMLEIANINSGKHKIDKQ 292
Cdd:PRK11466 436 EAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDdLRAITDSGESLLTILNDILDYSAIEAGGKNVSVS 515

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 293 wvDLSTVCQDVVEFLLPISDEKQQVLSFR------EDEPYKLQGEPSLLFRAIYNVVENAIKYTpEQGNIEVVVDHFGVV 366
Cdd:PRK11466 516 --DEPFEPRPLLESTLQLMSGRVKGRPIRlatdiaDDLPTALMGDPRRIRQVITNLLSNALRFT-DEGSIVLRSRTDGEQ 592

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767073357 367 VI----DNGLGVSDEDKGRIKEPMYRADKSRThqGFGLGLSLVEAVMKSHGGDLAFSDN-NPGLRTRLYFPLK 434
Cdd:PRK11466 593 WLveveDSGCGIDPAKLAEIFQPFVQVSGKRG--GTGLGLTISSRLAQAMGGELSATSTpEVGSCFCLRLPLR 663
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 337-420 1.36e-07

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 49.80  E-value: 1.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 337 RAIYNVVENAIKYTPEQGNIEVVVDHFGVVVI-----DNGLGVSDEDKGRIKEPMYRA--DKSRTHQGFGLGLSLVEAVM 409
Cdd:cd16925    7 RVVLNLLSNAFKFTPDGGRIRCILEKFRLNRFlltvsDSGPGIPPNLREEIFERFRQGdgSSTRAHGGTGLGLSIVKEFV 86

                         90
                 ....*....|.
gi 767073357 410 KSHGGDLAFSD 420
Cdd:cd16925   87 ELHGGTVTVSD 97
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 224-434 3.39e-07

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 52.43  E-value: 3.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 224 ELSVGMAHDLRTPIARMKLRLEDLLTKdtapftkdlEACHDDLevllgmFNGML-EIANINS--------GKHK-IDKQW 293
Cdd:COG5805  289 QLAAGIAHEIRNPLTSIKGFLQLLQPG---------IEDKEEY------FDIMLsELDRIESiiseflalAKPQaVNKEK 353

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 294 VDLSTVCQDVVEFLLP--ISDEKQQVLSFrEDEPYKLQGEPSLLFRAIYNVVENAIKYTPEQGNI----EVVVDHFGVVV 367
Cdd:COG5805  354 ENINELIQDVVTLLETeaILHNIQIRLEL-LDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTItihtEEEDNSVIIRV 432

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767073357 368 IDNGLGVSDEDKGRIKEPMYradkSRTHQGFGLGLSLVEAVMKSHGGDLAFsDNNPGLRT--RLYFPLK 434
Cdd:COG5805  433 IDEGIGIPEERLKKLGEPFF----TTKEKGTGLGLMVSYKIIENHNGTIDI-DSKVGKGTtfTITLPLS 496
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 332-433 4.51e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 48.19  E-value: 4.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 332 PSLLFRAIYNVVENAIKYTPEQGNIEVVVDHFGVVVI----DNGLGVSDEDKGRIKEPMYRAdkSRTHQGFGLGLSLVEA 407
Cdd:cd16943    1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLieveDTGSGIDPEILGRIFDPFFTT--KPVGEGTGLGLSLSYR 78

                         90       100
                 ....*....|....*....|....*..
gi 767073357 408 VMKSHGGDLAFSDNNP-GLRTRLYFPL 433
Cdd:cd16943   79 IIQKHGGTIRVASVPGgGTRFTIILPI 105
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 313-420 5.31e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 48.78  E-value: 5.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 313 EKQQVLSFREDEPYKLQGEPSLLFRAIYNVVENAIKYTPEQGNIEVVVDHFGVVVI--DNGLGVSDEDKGRIKEPMYRAD 390
Cdd:cd16954   16 RKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWCLEFVEVTARQTDGGLHLIvdDDGPGVPESQRSKIFQRGQRLD 95

                         90       100       110
                 ....*....|....*....|....*....|
gi 767073357 391 KSRTHQgfGLGLSLVEAVMKSHGGDLAFSD 420
Cdd:cd16954   96 EQRPGQ--GLGLAIAKEIVEQYGGELSLSD 123
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 322-434 6.62e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 48.28  E-value: 6.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 322 EDEPYKLQGEPSLLFRAIYNVVENAIKYTPEqGNIEVVVDHFGVVVI-----DNGLGVSDEDKGRIKEPMYRADKSRT-- 394
Cdd:cd16947    8 PDRPIYANANTEALQRILKNLISNAIKYGSD-GKFLGMTLREDEKHVyidiwDKGKGISETEKDHVFERLYTLEDSRNsa 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 767073357 395 HQGFGLGLSLVEAVMKSHGGDLAFSdNNPGLRTRLYFPLK 434
Cdd:cd16947   87 KQGNGLGLTITKRLAESMGGSIYVN-SKPYEKTVFTVTLK 125
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 368-432 8.80e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 47.15  E-value: 8.80e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767073357 368 IDNGLGVSDEDKGRIKEPmYRADKSRthqGFGLGLSLVEAVMKSHGGDLAFSDNNP-GLRTRLYFP 432
Cdd:cd16944   47 CDNGKGFPREMRHRATEP-YVTTRPK---GTGLGLAIVKKIMEEHGGRISLSNREAgGACIRIILP 108
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 219-280 9.89e-06

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 42.97  E-value: 9.89e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767073357 219 EESLKELSVGMAHDLRTPIARMKLRLEDLL--TKDTAPFTKDLEACHDDLEVLLGMFNGMLEIA 280
Cdd:cd00082    1 LQAKGEFLANVSHELRTPLTAIRGALELLEeeLLDDEEQREYLERIREEAERLLRLINDLLDLS 64
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 369-424 2.22e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 43.15  E-value: 2.22e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767073357 369 DNGLGVSDEDKGRIKEPMYRADKsrthQGFGLGLSLVEAVMKSHGGDLAFSDNNPG 424
Cdd:cd16920   44 DTGPGIAEEVAGQLFDPFYTTKS----EGLGMGLSICRSIIEAHGGRLSVESPAGG 95
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 334-432 2.52e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 43.04  E-value: 2.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 334 LLFrAIYNVVENAIKYTPEQGNIEVVVDHFGVVVI----DNGLGVSDEDKGRIKEPMYRADKSRTHQ-GFGLGLSLVEAV 408
Cdd:cd16948    6 LSF-IIGQIVSNALKYSKQGGKIEIYSETNEQGVVlsikDFGIGIPEEDLPRVFDKGFTGENGRNFQeSTGMGLYLVKKL 84

                         90       100
                 ....*....|....*....|....*.
gi 767073357 409 MKS--HGGDLAfSDNNPGLRTRLYFP 432
Cdd:cd16948   85 CDKlgHKIDVE-SEVGEGTTFTITFP 109
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 302-419 3.45e-05

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 46.38  E-value: 3.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 302 DVVEFLLPISDEKQQ--VLSFREDEPYKLQGEPSLLFRAIYNVVENAIKYTpEQGNI---------EVVVDHFGVVVIDN 370
Cdd:PRK11107 374 EVVTLLAHSAHEKGLelTLNIDPDVPDNVIGDPLRLQQIITNLVGNAIKFT-ESGNIdilvelralSNTKVQLEVQIRDT 452

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767073357 371 GLGVSDEDKGRIKEPMYRADKS--RTHQGFGLGLSLVEAVMKSHGGDLAFS 419
Cdd:PRK11107 453 GIGISERQQSQLFQAFRQADASisRRHGGTGLGLVITQKLVNEMGGDISFH 503
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
217-440 3.64e-05

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 46.12  E-value: 3.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 217 KKEESLKEL---------SVGM-----AHDLRTPIARMKLRLEDLLTKdTAPFTKD--LEACHDDLEVLLGMFNGMLEIA 280
Cdd:PRK10841 428 KMEESLQEMaqaaeqasqSKSMflatvSHELRTPLYGIIGNLDLLQTK-ELPKGVDrlVTAMNNSSSLLLKIISDILDFS 506

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 281 NINSGKHKIDKQwvDLStvCQDVVEFL----LPISDEKQQVL-SFRE-DEPYKLQGEPSLLFRAIYNVVENAIKYTPEQG 354
Cdd:PRK10841 507 KIESEQLKIEPR--EFS--PREVINHItanyLPLVVKKRLGLyCFIEpDVPVALNGDPMRLQQVISNLLSNAIKFTDTGC 582

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 355 NIEVVVDHFGVVVI---DNGLGVSDEDKGRIKEPMYRA--DKSRTHQGFGLGLSLVEAVMKSHGGDLAFsDNNPGL---- 425
Cdd:PRK10841 583 IVLHVRVDGDYLSFrvrDTGVGIPAKEVVRLFDPFFQVgtGVQRNFQGTGLGLAICEKLINMMDGDISV-DSEPGMgsqf 661

                        250       260
                 ....*....|....*....|.
gi 767073357 426 --RTRLY----FPLKPQQNRQ 440
Cdd:PRK10841 662 tiRIPLYgaqyPQKKGVEGLQ 682
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 368-432 4.91e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 42.39  E-value: 4.91e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767073357 368 IDNGLGVSDEDKGRIKEPMYradkSRTHQGFGLGLSLVEAVMKSHGGDLAFsDNNPGlRT--RLYFP 432
Cdd:cd16918   49 IDNGPGIPPDLQDTIFYPMV----SGRENGTGLGLAIAQNIVSQHGGVIEC-DSQPG-HTvfSVSLP 109
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 369-432 7.63e-05

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 41.98  E-value: 7.63e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767073357 369 DNGLGVSDEDKGRIKEPMYRADKsrTHQGFGLGLSLVEAVMKSHGGDLA-FSDNNPGLRTRLYFP 432
Cdd:cd16919   54 DTGSGMPAEVLRRAFEPFFTTKE--VGKGTGLGLSMVYGFVKQSGGHLRiYSEPGVGTTVRIYLP 116
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 228-285 7.74e-05

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 40.66  E-value: 7.74e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767073357  228 GMAHDLRTPIARMKLRLEDLLTKDTAPFTKD-LEACHDDLEVLLGMFNGMLEIANINSG 285
Cdd:pfam00512   8 NLSHELRTPLTAIRGYLELLRDEKLDEEQREyLETILRSAERLLRLINDLLDLSRIEAG 66
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 228-285 1.95e-04

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 39.47  E-value: 1.95e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 767073357   228 GMAHDLRTPIARMKLRLEDLL-TKDTAPFTKDLEACHDDLEVLLGMFNGMLEIANINSG 285
Cdd:smart00388   8 NLSHELRTPLTAIRGYLELLLdTELSEEQREYLETILREAERLLRLINDLLDLSRIEAG 66
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 331-436 2.02e-04

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 43.30  E-value: 2.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 331 EPSLLFRAIYNVVENAI----KYTPEQGNIEVVVDHFGVVVI----DNGLGVSDEDKGRIKEPMYRadkSRTHQGFGLGL 402
Cdd:COG3290  278 SDTDLVTILGNLLDNAIeaveKLPEEERRVELSIRDDGDELVieveDSGPGIPEELLEKIFERGFS---TKLGEGRGLGL 354

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767073357 403 SLVEAVMKSHGGDLAFSDNNPGLRT-RLYFPLKPQ 436
Cdd:COG3290  355 ALVKQIVEKYGGTIEVESEEGEGTVfTVRLPKEGE 389
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 155-416 4.20e-04

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 42.75  E-value: 4.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 155 VILMLAGALLFAI---------SILKKLERVNHGMNRVILGEKGVKLPVSAND-------------DEFDVLTIHLNFLI 212
Cdd:COG4192  328 LLAIALLSLLLAVlinyfyvrrRLVKRLNALSDAMAAIAAGDLDVPIPVDGNDeigriarllrvfrDQAIEKTQELETEI 407

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 213 EQVEKKEESLK----EL-------SVG-----MAHDLRTPIARMKLRLedlLTKDTAPFTKDLEACHDDLEVLLGMFNGM 276
Cdd:COG4192  408 EERKRIEKNLRqtqdELiqaakmaVVGqtmtsLAHELNQPLNAMSMYL---FSAKKALEQENYAQLPTSLDKIEGLIERM 484

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 277 LEIanINSGKHKIDK-----QWVDLSTVCQDVVEfLLPISDEKQQVLSFREDEPyKLQGEPSLLFRAIYNVVENAIKYTP 351
Cdd:COG4192  485 DKI--IKSLRQFSRKsdtplQPVDLRQVIEQAWE-LVESRAKPQQITLHIPDDL-MVQGDQVLLEQVLVNLLVNALDAVA 560

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767073357 352 EQGNI----EVVVDHFGVVVIDNGLGVSDEDKgrIKEPMYradkSRTHQGFGLGLSLVEAVMKSHGGDL 416
Cdd:COG4192  561 TQPQIsvdlLSNAENLRVAISDNGNGWPLVDK--LFTPFT----TTKEVGLGLGLSICRSIMQQFGGDL 623
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 341-433 4.85e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 39.23  E-value: 4.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 341 NVVENAIKYTPEQ--GNIEVVVDHFGVVVI----DNGLGVSDEDKGRIKEPMYRADKSRTHQGFGLGLSLVEAVMKSHGG 414
Cdd:cd16921    7 NLLGNAIKFRRPRrpPRIEVGAEDVGEEWTfyvrDNGIGIDPEYAEKVFGIFQRLHSREEYEGTGVGLAIVRKIIERHGG 86

                         90
                 ....*....|....*....
gi 767073357 415 DLaFSDNNPGLRTRLYFPL 433
Cdd:cd16921   87 RI-WLESEPGEGTTFYFTL 104
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 335-423 5.74e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 36.40  E-value: 5.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767073357 335 LFRAIYNVVENAIKYTP-EQGNIEVVVDHFGVVVI----DNGLGVSDEDKGRIKEPMY--RADKSRTHQGFGLGLSLVEA 407
Cdd:cd16953    1 LGQVLRNLIGNAISFSPpDTGRITVSAMPTGKMVTisveDEGPGIPQEKLESIFDRFYteRPANEAFGQHSGLGLSISRQ 80

                         90
                 ....*....|....*.
gi 767073357 408 VMKSHGGDLAFSDNNP 423
Cdd:cd16953   81 IIEAHGGISVAENHNQ 96
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 369-424 6.47e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 36.28  E-value: 6.47e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767073357 369 DNGLGVSDEDKGRIKEPMYRADKsrTHQGFGLGLSLVEAVMKSHGGDLAFSDNNPG 424
Cdd:cd16976   41 DNGPGIAEEHLSRVFDPFFTTKP--VGKGTGLGLSISYGIVEEHGGRLSVANEEGA 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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