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Conserved domains on  [gi|818242196|gb|KKP29319|]
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Phospholipid/glycerol acyltransferase [candidate division TM6 bacterium GW2011_GWF2_30_66]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 11415180)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid; 1-acyl-sn-glycerol-3-phosphate acyltransferase, for example, converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position by utilizing either acyl-CoA or acyl-ACP as the fatty acyl donor;

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0008654|GO:0016746
PubMed:  18718904|18931347
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 41-240 3.39e-36

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 127.43  E-value: 3.39e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196  41 NKFFFWMADKFYKLSLLVIFVPVEFVGKENI-TKTPSIIAANHQSSLDIPLVGSLLNGYPHlWMAWSALRRY-WIGPVIS 118
Cdd:COG0204    9 RRFRYRLVRLWARLLLRLLGVRVRVEGLENLpADGPVLIVANHQSWLDILLLLAALPRPVR-FVAKKELFKIpLLGWLLR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196 119 RM-AVLVDVTSSMKAMKSLLKAVEMFKdKNRHVIIFPEGARSSGNQVADFFAGFVILAKKTGRPVIPVLLLNAYDAYPPG 197
Cdd:COG0204   88 ALgAIPVDRSKRRAALRALRQAVEALK-AGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERALPKG 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 818242196 198 aFFINWVPMKVVVGKPVLYADFGSDD--EFKNFVRNWFVDNVNEY 240
Cdd:COG0204  167 -FLPRPGKVTVRIGPPIDPSDLEGEDrrELAERLRAAIEALLAEL 210
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 41-240 3.39e-36

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 127.43  E-value: 3.39e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196  41 NKFFFWMADKFYKLSLLVIFVPVEFVGKENI-TKTPSIIAANHQSSLDIPLVGSLLNGYPHlWMAWSALRRY-WIGPVIS 118
Cdd:COG0204    9 RRFRYRLVRLWARLLLRLLGVRVRVEGLENLpADGPVLIVANHQSWLDILLLLAALPRPVR-FVAKKELFKIpLLGWLLR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196 119 RM-AVLVDVTSSMKAMKSLLKAVEMFKdKNRHVIIFPEGARSSGNQVADFFAGFVILAKKTGRPVIPVLLLNAYDAYPPG 197
Cdd:COG0204   88 ALgAIPVDRSKRRAALRALRQAVEALK-AGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERALPKG 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 818242196 198 aFFINWVPMKVVVGKPVLYADFGSDD--EFKNFVRNWFVDNVNEY 240
Cdd:COG0204  167 -FLPRPGKVTVRIGPPIDPSDLEGEDrrELAERLRAAIEALLAEL 210
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 53-232 3.24e-34

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 121.22  E-value: 3.24e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196  53 KLSLLVIFVPVEFVGKENI-TKTPSIIAANHQSSLDIPLVGSLLNGYPHlWMAWSALRRY-WIGPVISRM-AVLVDVTSS 129
Cdd:cd07989    2 RLLLRLLGVRVRVEGLENLpPKGPVIIVANHQSYLDPLVLGAALPRPIR-FVAKKELFKIpFLGWLLRLLgAIPIDRGNG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196 130 MKAMKSLLKAVEMFKdKNRHVIIFPEGARSSGNQVADFFAGFVILAKKTGRPVIPVLLLNAYDAYPPGAFFINWVPMKVV 209
Cdd:cd07989   81 RSAREALREAIEALK-EGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLPRPGRVTVR 159

                        170       180
                 ....*....|....*....|...
gi 818242196 210 VGKPVLYADFGSDDEFKNFVRNW 232
Cdd:cd07989  160 IGEPIPPEGLELAEEDRKELREK 182
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 61-187 1.18e-19

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 81.62  E-value: 1.18e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196   61 VPVEFVGKENI-TKTPSIIAANHQSSLDIPLVGSLLnGYPHLWMAWSALRRY-WIGPVISRM-AVLVDvTSSMKAMKSLL 137
Cdd:TIGR00530   2 LKVEVVGPENLpAKSPVLVVANHQSNLDPLTLSAAF-PPPIVFIAKKELKWIpFFGIMLWLTgAIFID-RENIRAIATAL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 818242196  138 KAVEMFKDKNRHVIIFPEGARSSGNQVADFFAGFVILAKKTGRPVIPVLL 187
Cdd:TIGR00530  80 KAAIEVLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVL 129
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 63-185 1.23e-17

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 76.55  E-value: 1.23e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196   63 VEFVGKENI-TKTPSIIAANHQSSLDIPLVGSLL---NGYPHLWMAWSALRRYWIGPVISRM-AVLVDVTSSMKAMKSLL 137
Cdd:pfam01553   2 IEVHGLENLpRGGPAIVVANHQSYLDVLLLSLALykrGRPLVFVAKKELFDIPLVGWLMRLLgCIFIDRKNRKDAAGTLE 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 818242196  138 KAVEMFKdKNRHVIIFPEGARSSGNQVADFFAGFVILAKKTGRPVIPV 185
Cdd:pfam01553  82 YLVELLR-EGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPV 128
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 77-185 6.56e-17

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 74.31  E-value: 6.56e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196    77 IIAANHQSSLDIPLVGSLLNGYPHLW--MAWSALRRYW-IGPVISRM-AVLVDVTSSMKAMKSLLKAVEMFKDkNRHVII 152
Cdd:smart00563   2 LVVANHQSFLDPLVLSALLPRKLGRVrfVAKKELFYVPlLGWLLRLLgAIFIDRSNGRKARAALREAVELLKE-GEWLLI 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 818242196   153 FPEGARSSGNQVADFFAGFVILAKKTGRPVIPV 185
Cdd:smart00563  81 FPEGTRSRPGKLLPFKKGAARLALEAGVPIVPV 113
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
2-185 5.74e-16

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 76.93  E-value: 5.74e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196    2 IIFKLFRTIITYILFILLVLVFAIPFIIVM--------------LLPEKWRYDnkFFFWMADKFYKlsllvifvpVEFVG 67
Cdd:PRK06814  377 VLNAAFMVAGTIILALLQALGFSIPWIILFialanlivaililrLLPTNLLRD--IFSILFRAFYR---------VEVKG 445

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196   68 KENITK--TPSIIAANHQSSLDIPLVGSLLNGYPHLWMAWSALRRYWIGPVIsRM--AVLVDVTSSMkAMKSLLKAVEmf 143
Cdd:PRK06814  446 LENLQKagKKAVIAANHVSFLDGPLLAAYLPEEPTFAIDTDIAKAWWVKPFL-KLakALPVDPTNPM-ATRTLIKEVQ-- 521

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 818242196  144 kdKNRHVIIFPEGARSSGNQVADFFAGFVILAKKTGRPVIPV 185
Cdd:PRK06814  522 --KGEKLVIFPEGRITVTGSLMKIYDGPGMIADKAGAMVVPV 561
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 41-240 3.39e-36

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 127.43  E-value: 3.39e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196  41 NKFFFWMADKFYKLSLLVIFVPVEFVGKENI-TKTPSIIAANHQSSLDIPLVGSLLNGYPHlWMAWSALRRY-WIGPVIS 118
Cdd:COG0204    9 RRFRYRLVRLWARLLLRLLGVRVRVEGLENLpADGPVLIVANHQSWLDILLLLAALPRPVR-FVAKKELFKIpLLGWLLR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196 119 RM-AVLVDVTSSMKAMKSLLKAVEMFKdKNRHVIIFPEGARSSGNQVADFFAGFVILAKKTGRPVIPVLLLNAYDAYPPG 197
Cdd:COG0204   88 ALgAIPVDRSKRRAALRALRQAVEALK-AGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERALPKG 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 818242196 198 aFFINWVPMKVVVGKPVLYADFGSDD--EFKNFVRNWFVDNVNEY 240
Cdd:COG0204  167 -FLPRPGKVTVRIGPPIDPSDLEGEDrrELAERLRAAIEALLAEL 210
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 53-232 3.24e-34

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 121.22  E-value: 3.24e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196  53 KLSLLVIFVPVEFVGKENI-TKTPSIIAANHQSSLDIPLVGSLLNGYPHlWMAWSALRRY-WIGPVISRM-AVLVDVTSS 129
Cdd:cd07989    2 RLLLRLLGVRVRVEGLENLpPKGPVIIVANHQSYLDPLVLGAALPRPIR-FVAKKELFKIpFLGWLLRLLgAIPIDRGNG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196 130 MKAMKSLLKAVEMFKdKNRHVIIFPEGARSSGNQVADFFAGFVILAKKTGRPVIPVLLLNAYDAYPPGAFFINWVPMKVV 209
Cdd:cd07989   81 RSAREALREAIEALK-EGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLPRPGRVTVR 159

                        170       180
                 ....*....|....*....|...
gi 818242196 210 VGKPVLYADFGSDDEFKNFVRNW 232
Cdd:cd07989  160 IGEPIPPEGLELAEEDRKELREK 182
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 61-187 1.18e-19

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 81.62  E-value: 1.18e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196   61 VPVEFVGKENI-TKTPSIIAANHQSSLDIPLVGSLLnGYPHLWMAWSALRRY-WIGPVISRM-AVLVDvTSSMKAMKSLL 137
Cdd:TIGR00530   2 LKVEVVGPENLpAKSPVLVVANHQSNLDPLTLSAAF-PPPIVFIAKKELKWIpFFGIMLWLTgAIFID-RENIRAIATAL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 818242196  138 KAVEMFKDKNRHVIIFPEGARSSGNQVADFFAGFVILAKKTGRPVIPVLL 187
Cdd:TIGR00530  80 KAAIEVLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVL 129
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 63-185 1.23e-17

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 76.55  E-value: 1.23e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196   63 VEFVGKENI-TKTPSIIAANHQSSLDIPLVGSLL---NGYPHLWMAWSALRRYWIGPVISRM-AVLVDVTSSMKAMKSLL 137
Cdd:pfam01553   2 IEVHGLENLpRGGPAIVVANHQSYLDVLLLSLALykrGRPLVFVAKKELFDIPLVGWLMRLLgCIFIDRKNRKDAAGTLE 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 818242196  138 KAVEMFKdKNRHVIIFPEGARSSGNQVADFFAGFVILAKKTGRPVIPV 185
Cdd:pfam01553  82 YLVELLR-EGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPV 128
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 77-185 6.56e-17

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 74.31  E-value: 6.56e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196    77 IIAANHQSSLDIPLVGSLLNGYPHLW--MAWSALRRYW-IGPVISRM-AVLVDVTSSMKAMKSLLKAVEMFKDkNRHVII 152
Cdd:smart00563   2 LVVANHQSFLDPLVLSALLPRKLGRVrfVAKKELFYVPlLGWLLRLLgAIFIDRSNGRKARAALREAVELLKE-GEWLLI 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 818242196   153 FPEGARSSGNQVADFFAGFVILAKKTGRPVIPV 185
Cdd:smart00563  81 FPEGTRSRPGKLLPFKKGAARLALEAGVPIVPV 113
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
2-185 5.74e-16

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 76.93  E-value: 5.74e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196    2 IIFKLFRTIITYILFILLVLVFAIPFIIVM--------------LLPEKWRYDnkFFFWMADKFYKlsllvifvpVEFVG 67
Cdd:PRK06814  377 VLNAAFMVAGTIILALLQALGFSIPWIILFialanlivaililrLLPTNLLRD--IFSILFRAFYR---------VEVKG 445

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196   68 KENITK--TPSIIAANHQSSLDIPLVGSLLNGYPHLWMAWSALRRYWIGPVIsRM--AVLVDVTSSMkAMKSLLKAVEmf 143
Cdd:PRK06814  446 LENLQKagKKAVIAANHVSFLDGPLLAAYLPEEPTFAIDTDIAKAWWVKPFL-KLakALPVDPTNPM-ATRTLIKEVQ-- 521

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 818242196  144 kdKNRHVIIFPEGARSSGNQVADFFAGFVILAKKTGRPVIPV 185
Cdd:PRK06814  522 --KGEKLVIFPEGRITVTGSLMKIYDGPGMIADKAGAMVVPV 561
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 38-238 3.63e-15

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 71.69  E-value: 3.63e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196  38 RYDNKFFFWMADKFYKLSLLvIFVPVEFVGKENI--TKTPSIIAANHQSSLDIPLVGSLlnGYPHLWMAWSALrryWIGP 115
Cdd:PLN02901  13 RYRRKAQHFINKVWATLSTS-PFYKIEVEGLENLpsPDEPAVYVSNHQSFLDIYTLFHL--GRPFKFISKTSI---FLIP 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196 116 VISRMAVLVDV-----TSSMKAMKSLLKAVEMFKdKNRHVIIFPEGARSSGNQVADFFAGFVILAKKTGRPVIPVLLLNA 190
Cdd:PLN02901  87 IIGWAMYMTGHiplkrMDRRSQLECLKRCMELLK-KGASVFFFPEGTRSKDGKLAAFKKGAFSVAAKTGVPVVPITLVGT 165

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 818242196 191 YDAYPPGAFFI-NWVPMKVVVGKPVLyadfGSD-DEFKNFVRNWFVDNVN 238
Cdd:PLN02901 166 GKIMPNGKEGIlNPGSVKVVIHPPIE----GSDaDELCNEARKVIAESLV 211
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 75-218 1.21e-12

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 64.36  E-value: 1.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196  75 PSIIAANHQSSLDiPLVGSLLNGYPHLW-----MAWSALRRYwigPVISRM-AVLVDVTSSMKAMKSLLKAVEMFKDKNR 148
Cdd:cd06551   27 PVLFVSNHSSWWD-GLILFLLLERGLRRdvyglMDEELLERY---PFFTRLgAFSVDRDSPRSAAKSLKYVARLLSKPGS 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 818242196 149 HVIIFPEGARSSGNQVA-DFFAGFVILAKKTGRPVIPVLLLnaydaYPPGAfFINWVPMKVVVGKPVLYAD 218
Cdd:cd06551  103 VVWIFPEGTRTRRDKRPlQFKPGVAHLAEKAGVPIVPVALR-----YTFEL-FEQFPEIFVRIGPPIPYAE 167
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 59-230 3.46e-07

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 49.21  E-value: 3.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196  59 IFVPVEFVGKENITKTPSIIAA-NHQ-SSLDIPLVGSL-----LNGYPHLWMAWSALRRYWIGPVISRMAVlvdVTSSMK 131
Cdd:cd07987    4 YFRVYEVRGLENIPDEGPALLVhPHGgLPIDGALLAAAflllfPGRLPRALADHFLFPLPGLRDLLRRLGA---VPGSRE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196 132 AMKSLLKavemfkdKNRHVIIFPEGARSSGNQVADFFA-------GFVILAKKTGRPVIPVLLLNAYDAYP--------P 196
Cdd:cd07987   81 NCVRLLR-------EGELVLIFPGGAREALKSKREEYYllwkkrkGFARLALRAGAPIVPVFTFGEEELFRvlgdpdgpV 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 818242196 197 GAFFINWVPMK------VVVGKPVLYADFGSDDEFKNFVR 230
Cdd:cd07987  154 GKRLFRLLPLPrrlplyPVFGEPIVVPRPPIPDPPDEDVE 193
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 54-203 6.48e-07

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 48.76  E-value: 6.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196  54 LSLLVIFVPVEFVGKENITKTPSIIAANHQSSLDIPLVGSLlnGYPHLWMAWSALRRYWIGPVISRM-AVLVDVTSSmka 132
Cdd:cd07991    4 LLFAFGFYVIKVHGKPDPPEAPRIIVANHTSFIDPLILFSD--LFPSIVAKKELGKLPFIGTILRALgCIFVDRSEP--- 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 818242196 133 mKSLLKAVEMFKDKNRH-----VIIFPEGARSSGNQVADFFAG-FVilakkTGRPVIPVLLlnAYDaYPPGAFFINW 203
Cdd:cd07991   79 -KDRKKVVEEIKERATDpnwppILIFPEGTTTNGKALIMFKKGaFE-----PGVPVQPVAI--RYP-NKFVDAFWNS 146
PRK08043 PRK08043
bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;
77-185 3.49e-05

bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;


Pssm-ID: 181207 [Multi-domain]  Cd Length: 718  Bit Score: 44.70  E-value: 3.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196  77 IIAANHQSSLDIPLVGSLLNGYPHLWMAWSALRRY---WIGPVISrmAVLVDVTSSMkAMKSLLKAVEmfkdKNRHVIIF 153
Cdd:PRK08043  31 LITPNHVSFLDGILLALFLPVRPVFAVYTSISQQWymrWLKPYID--FVPLDPTKPM-AIKHLVRLVE----QGRPVVIF 103

                         90       100       110
                 ....*....|....*....|....*....|..
gi 818242196 154 PEGARSSGNQVADFFAGFVILAKKTGRPVIPV 185
Cdd:PRK08043 104 PEGRITVTGSLMKIYDGAGFVAAKSGATVIPV 135
LPLAT_DUF374-like cd07983
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; ...
 112-224 6.78e-05

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are the uncharacterized DUF374 phospholipid/glycerol acyltransferases and similar proteins.


Pssm-ID: 153245 [Multi-domain]  Cd Length: 189  Bit Score: 42.59  E-value: 6.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196 112 WIGPVISRMAVLVDVTSS----MKAMKSLLKAVEmfkdKNRHVIIFPEGARSSGNQVADffaGFVILAKKTGRPVIPV-- 185
Cdd:cd07983   62 IIARVLERLGIRVVRGSSsrggAAALREMLRALK----DGYNIAITPDGPRGPRYKVKP---GVILLARKSGAPIVPVai 134

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 818242196 186 -----LLLNAYDayppgAFFINWvP---MKVVVGKPvLYADFGSDDE 224
Cdd:cd07983  135 aasraWRLKSWD-----RFIIPK-PfsrVVIVFGEP-IHVPPDADEE 174
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 76-189 2.40e-04

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 41.15  E-value: 2.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196  76 SIIAANHQSSLDIPLVGSLLNGyPHLWMAWSALrrYWIgPVISRM-----AVLVDVTSSMKAMKSLLKAVEMFKDKNRHV 150
Cdd:PRK15018  67 AIYIANHQNNYDMVTASNIVQP-PTVTVGKKSL--LWI-PFFGQLywltgNLLIDRNNRTKAHGTIAEVVNHFKKRRISI 142

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 818242196 151 IIFPEGARSSGNQVADFFAGFVILAKKTGRPVIPVLLLN 189
Cdd:PRK15018 143 WMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIIPVCVST 181
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 12-187 6.05e-04

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 40.68  E-value: 6.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196   12 TYILFILLVLVFAIPFIIVMLLPEkwrYDNKFFFWMADK-FYKLsllvifvpvEFVGKENI-TKTPSIIAANHQSSLDIP 89
Cdd:PRK08633  389 AGLFYLIALVTLIGTLYTLLLLPD---SLLRFLLLLLMHtRYRL---------RVEGRENIpAKGGALLLGNHVSWIDWA 456

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196   90 LvgsllngyphLWMAWS------ALRRYWIGPVISRMAVLVDVTS-SMKAMKSLLKAVEMFKDKNRHVIIFPEGARSSGN 162
Cdd:PRK08633  457 L----------LQAASPrpirfvMERSIYEKWYLKWFFKLFGVIPiSSGGSKESLEFIRKALDDGEVVCIFPEGAITRNG 526

                         170       180
                  ....*....|....*....|....*
gi 818242196  163 QVADFFAGFVILAKKTGRPVIPVLL 187
Cdd:PRK08633  527 QLNEFKRGFELIVKGTDVPIIPFYI 551
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 42-219 3.42e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 37.63  E-value: 3.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196  42 KFFFWMADKFYklsllviFVPVEFVGKENITKT-PSIIAANHQSSL-DIPLVGSLLNGYPHLWMAWSALRRywigPVISR 119
Cdd:cd07992    2 RLLSRVILRIY-------FRRITVVGRENVPKDgPVIFLGNHPNALiDPLLLAATLRRPVRFLAKADLFKN----PLIGW 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196 120 MAVLVDV-----------TSSMKAMKSLL-KAVEMFKDKNRHVIIFPEGARSSGNQVADFFAGFVILAK------KTGRP 181
Cdd:cd07992   71 LLESFGAipvyrpkdlarGGIGKISNAAVfDAVGEALKAGGAIGIFPEGGSHDRPRLLPLKAGAARMALealeagQKDVK 150

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 818242196 182 VIPVlLLNAYDAYPPGAFFInwvpmkVVVGKPVLYADF 219
Cdd:cd07992  151 IVPV-GLNYEDKSRFRSRVL------VEFGKPISVSAF 181
COG2121 COG2121
Uncharacterized conserved protein, lysophospholipid acyltransferase (LPLAT) superfamily ...
 130-225 3.61e-03

Uncharacterized conserved protein, lysophospholipid acyltransferase (LPLAT) superfamily [Function unknown];


Pssm-ID: 441724 [Multi-domain]  Cd Length: 225  Bit Score: 37.55  E-value: 3.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196 130 MKAMKSLLKAVEmfkdKNRHVIIFPEGARSSGNQVADffaGFVILAKKTGRPVIPV-------LLLNAYDayppgAFFIN 202
Cdd:COG2121  107 AAALREMLRALK----EGYSVAITPDGPRGPRRVVKP---GIIYLARKSGAPIVPVavaasrrWRLKSWD-----RFVLP 174

                         90       100
                 ....*....|....*....|....*.
gi 818242196 203 WvP---MKVVVGKPVLYADFGSDDEF 225
Cdd:COG2121  175 L-PfsrVVIVYGEPIYVPPDADEEEL 199
LPLAT_LABLAT-like cd07984
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; ...
 63-185 5.09e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lipid A biosynthesis lauroyl/myristoyl (LABLAT, HtrB) acyltransferases and similar proteins.


Pssm-ID: 153246 [Multi-domain]  Cd Length: 192  Bit Score: 36.81  E-value: 5.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818242196  63 VEFVGKENITK-----TPSIIAANHQSSLDIPLVGSLLNGYPHLWMAwSALRRYWIGPVISRM-----AVLVDVTSSMKA 132
Cdd:cd07984    4 VEREGLEHLEAalakgKGVILLTAHFGNWELAGLALALLGYPVTVVY-RPLKNPLLDRLITRGrerfgARLIPRGGGLRE 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 818242196 133 MKSLLKavemfkdKNRHVIIFP-EGARSSGNQVADFF-------AGFVILAKKTGRPVIPV 185
Cdd:cd07984   83 LIRALK-------KGEIVGILPdQDPGRKGGVFVPFFgrpaatpTGPARLALKTGAPVVPA 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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