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Conserved domains on  [gi|818341340|gb|KKQ23363|]
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Glycosyltransferase [Candidatus Roizmanbacteria bacterium GW2011_GWC1_37_12]

Protein Classification

DPM1_like and GtrA domain-containing protein( domain architecture ID 10157757)

DPM1_like and GtrA domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 6-236 3.23e-69

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


:

Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 216.63  E-value: 3.23e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340   6 VILPSFNEAENIAPLIkkiEEINKKLVNWDINILVVDSYSTDNTGNVVKDLQKTIPTLHII-EVPKEGLGKAYLRGFNYA 84
Cdd:cd06442    1 IIIPTYNERENIPELI---ERLDAALKGIDYEIIVVDDNSPDGTAEIVRELAKEYPRVRLIvRPGKRGLGSAYIEGFKAA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340  85 INKFnpylIIQMDADYQHDPERLTEFFE-QIQKGADFVVGTRYSKGGSIpKNWAIHRKILSIGANLFIRLgFMKLKTSEW 163
Cdd:cd06442   78 RGDV----IVVMDADLSHPPEYIPELLEaQLEGGADLVIGSRYVEGGGV-EGWGLKRKLISRGANLLARL-LLGRKVSDP 151

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 818341340 164 TNGYRAIKTWVIKGALDHIkNYSGYVFQVAMIDYALKNNAKMSEIPVNFKERKFGISKINASqyvfQIIQYVL 236
Cdd:cd06442  152 TSGFRAYRREVLEKLIDSL-VSKGYKFQLELLVRARRLGYRIVEVPITFVDREHGESKLGGK----EIVEYLK 219
GtrA COG2246
Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose) [Lipid ...
 238-368 2.37e-23

Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose) [Lipid transport and metabolism];


:

Pssm-ID: 441847  Cd Length: 133  Bit Score: 94.12  E-value: 2.37e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340 238 HSSFIKFVIVGLIGFGVDFGISYLGIQKFHQAVWLITLLSTETAIVSNFILNNFWSFRykkiEGGTGNYLMSFLKFNLVS 317
Cdd:COG2246    7 LRQLLRFGLVGGLGTLVDLGVFYLLVELLGLPPLLANVIAFVVAVIVNFLLNRRWTFR----SRGGRSRLREFLRFLLVS 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 818341340 318 SGSIAIQTIGMQILVGVFGrdLWYLYKILIIAFVIIPYSYILYNKFIWKNK 368
Cdd:COG2246   83 LVGLALNLGLLALLVYVLG--LPYLLAKLIGIVVGTVFNFLLSRRWVFRKK 131
 
Name Accession Description Interval E-value
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 6-236 3.23e-69

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 216.63  E-value: 3.23e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340   6 VILPSFNEAENIAPLIkkiEEINKKLVNWDINILVVDSYSTDNTGNVVKDLQKTIPTLHII-EVPKEGLGKAYLRGFNYA 84
Cdd:cd06442    1 IIIPTYNERENIPELI---ERLDAALKGIDYEIIVVDDNSPDGTAEIVRELAKEYPRVRLIvRPGKRGLGSAYIEGFKAA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340  85 INKFnpylIIQMDADYQHDPERLTEFFE-QIQKGADFVVGTRYSKGGSIpKNWAIHRKILSIGANLFIRLgFMKLKTSEW 163
Cdd:cd06442   78 RGDV----IVVMDADLSHPPEYIPELLEaQLEGGADLVIGSRYVEGGGV-EGWGLKRKLISRGANLLARL-LLGRKVSDP 151

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 818341340 164 TNGYRAIKTWVIKGALDHIkNYSGYVFQVAMIDYALKNNAKMSEIPVNFKERKFGISKINASqyvfQIIQYVL 236
Cdd:cd06442  152 TSGFRAYRREVLEKLIDSL-VSKGYKFQLELLVRARRLGYRIVEVPITFVDREHGESKLGGK----EIVEYLK 219
PLN02726 PLN02726
dolichyl-phosphate beta-D-mannosyltransferase
 6-228 4.98e-42

dolichyl-phosphate beta-D-mannosyltransferase


Pssm-ID: 215385 [Multi-domain]  Cd Length: 243  Bit Score: 147.15  E-value: 4.98e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340   6 VILPSFNEAENIAPLIKKIEEINKKLVNWDIniLVVDSYSTDNTGNVVKDLQKTIPTLHIIEVP---KEGLGKAYLRGFN 82
Cdd:PLN02726  13 IIVPTYNERLNIALIVYLIFKALQDVKDFEI--IVVDDGSPDGTQDVVKQLQKVYGEDRILLRPrpgKLGLGTAYIHGLK 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340  83 YAINKFnpylIIQMDADYQHDPERLTEFFE-QIQKGADFVVGTRYSKGGSIpKNWAIHRKILSIGANLFIRLgFMKLKTS 161
Cdd:PLN02726  91 HASGDF----VVIMDADLSHHPKYLPSFIKkQRETGADIVTGTRYVKGGGV-HGWDLRRKLTSRGANVLAQT-LLWPGVS 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 818341340 162 EWTNGYRAIKTWVIKGALDHIKNySGYVFQVAMIDYALKNNAKMSEIPVNFKERKFGISKINASQYV 228
Cdd:PLN02726 165 DLTGSFRLYKRSALEDLVSSVVS-KGYVFQMEIIVRASRKGYRIEEVPITFVDRVYGESKLGGSEIV 230
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 6-220 1.04e-29

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 113.26  E-value: 1.04e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340   6 VILPSFNEAENIAPLIKKIEEINKKlvnwDINILVVDSYSTDNTGNVVKDLQKTIPTLHIIEVPK-EGLGKAYLRGFNYA 84
Cdd:COG0463    6 VVIPTYNEEEYLEEALESLLAQTYP----DFEIIVVDDGSTDGTAEILRELAAKDPRIRVIRLERnRGKGAARNAGLAAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340  85 INKFnpylIIQMDADYQHDPERLTEFFEQIQK-GADFVVGTRYSKGGSIPknwaiHRKILSIGANLFIRLgfmkLKTSEW 163
Cdd:COG0463   82 RGDY----IAFLDADDQLDPEKLEELVAALEEgPADLVYGSRLIREGESD-----LRRLGSRLFNLVRLL----TNLPDS 148

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 818341340 164 TNGYRAIKtwviKGALDHIKNYSGYVFQVAMIdYALKNNAKMSEIPVNFKERKFGIS 220
Cdd:COG0463  149 TSGFRLFR----REVLEELGFDEGFLEDTELL-RALRHGFRIAEVPVRYRAGESKLN 200
GtrA COG2246
Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose) [Lipid ...
 238-368 2.37e-23

Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose) [Lipid transport and metabolism];


Pssm-ID: 441847  Cd Length: 133  Bit Score: 94.12  E-value: 2.37e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340 238 HSSFIKFVIVGLIGFGVDFGISYLGIQKFHQAVWLITLLSTETAIVSNFILNNFWSFRykkiEGGTGNYLMSFLKFNLVS 317
Cdd:COG2246    7 LRQLLRFGLVGGLGTLVDLGVFYLLVELLGLPPLLANVIAFVVAVIVNFLLNRRWTFR----SRGGRSRLREFLRFLLVS 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 818341340 318 SGSIAIQTIGMQILVGVFGrdLWYLYKILIIAFVIIPYSYILYNKFIWKNK 368
Cdd:COG2246   83 LVGLALNLGLLALLVYVLG--LPYLLAKLIGIVVGTVFNFLLSRRWVFRKK 131
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 6-153 1.03e-20

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 87.84  E-value: 1.03e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340    6 VILPSFNEAENIAPLIKKIEEINKKlvnwDINILVVDSYSTDNTGNVVKDLQKTIPTLHIIEVPK-EGLGKAYLRGFNYA 84
Cdd:pfam00535   2 VIIPTYNEEKYLLETLESLLNQTYP----NFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIRLPEnRGKAGARNAGLRAA 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340   85 inkFNPYLIIqMDADYQHDPERLTEFFEQIQK-GADFVVGTRYSKGGSIPKNWAIHRKILSIGANLFIRL 153
Cdd:pfam00535  78 ---TGDYIAF-LDADDEVPPDWLEKLVEALEEdGADVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLR 143
GtrA pfam04138
GtrA-like protein; Members of this family are predicted to be integral membrane proteins with ...
 243-365 2.26e-17

GtrA-like protein; Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.


Pssm-ID: 427738  Cd Length: 116  Bit Score: 77.20  E-value: 2.26e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340  243 KFVIVGLIGFGVDFGISYLGIQKFHQAVWLITLLSTETAIVSNFILNNFWSFRykkieGGTGNYLMSFLKFNLVSSGSIA 322
Cdd:pfam04138   1 RFLLVGVLGTLVDLAVFLLLLELFGLSYLLANAIAFVVAILVNFLLNRRWTFR-----DRRSGSLRELLRFFLVSLAGLL 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 818341340  323 IQTIGMQILVGVFGRDLWYLYkiLIIAFVIIPYSYILYNKFIW 365
Cdd:pfam04138  76 LNLLLLWLLVDGLGLPPLLAK--LVGIAVGTVVNFLLSRFFVF 116
glyco_like_mftF TIGR04283
transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it ...
 6-56 1.80e-04

transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it sugar moiety, as part of a biosynthetic pathway. Other proposed members of the pathway include another transferase (TIGR04282), a phosphoesterase, and a radical SAM enzyme (TIGR04167) whose C-terminal domain (pfam12345) frequently contains a selenocysteine. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 275103 [Multi-domain]  Cd Length: 220  Bit Score: 42.50  E-value: 1.80e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 818341340    6 VILPSFNEAENIAPLIKKIEEINKklvnwDINILVVDSYSTDNTGNVVKDL 56
Cdd:TIGR04283   3 IIIPVLNEAATLPELLADLQALRG-----DAEVIVVDGGSTDGTVEIARSL 48
EPS_HpsE NF038302
hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;
5-80 2.81e-03

hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;


Pssm-ID: 439602 [Multi-domain]  Cd Length: 307  Bit Score: 39.01  E-value: 2.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340   5 VVIlPSFNEAENIAPLIKKI-EEINKKLVNWDIniLVVDSYSTDNTGNVVKDLQKTIP---TLHIIEVPKEGLGKAYLRG 80
Cdd:NF038302   5 VAI-PTYNGANRLPEVLERLrSQIGTESLSWEI--IVVDNNSTDNTAQVVQEYQKNWPspyPLRYCFEPQQGAAFARQRA 81
 
Name Accession Description Interval E-value
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 6-236 3.23e-69

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 216.63  E-value: 3.23e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340   6 VILPSFNEAENIAPLIkkiEEINKKLVNWDINILVVDSYSTDNTGNVVKDLQKTIPTLHII-EVPKEGLGKAYLRGFNYA 84
Cdd:cd06442    1 IIIPTYNERENIPELI---ERLDAALKGIDYEIIVVDDNSPDGTAEIVRELAKEYPRVRLIvRPGKRGLGSAYIEGFKAA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340  85 INKFnpylIIQMDADYQHDPERLTEFFE-QIQKGADFVVGTRYSKGGSIpKNWAIHRKILSIGANLFIRLgFMKLKTSEW 163
Cdd:cd06442   78 RGDV----IVVMDADLSHPPEYIPELLEaQLEGGADLVIGSRYVEGGGV-EGWGLKRKLISRGANLLARL-LLGRKVSDP 151

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 818341340 164 TNGYRAIKTWVIKGALDHIkNYSGYVFQVAMIDYALKNNAKMSEIPVNFKERKFGISKINASqyvfQIIQYVL 236
Cdd:cd06442  152 TSGFRAYRREVLEKLIDSL-VSKGYKFQLELLVRARRLGYRIVEVPITFVDREHGESKLGGK----EIVEYLK 219
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 6-195 8.85e-43

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 146.95  E-value: 8.85e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340   6 VILPSFNEAENIAPLIKKIEEINKKLVNWDIniLVVDSYSTDNTGNVVKDLQKTIPTLHIIEVPKE-GLGKAYLRGFNYA 84
Cdd:cd04179    1 VVIPAYNEEENIPELVERLLAVLEEGYDYEI--IVVDDGSTDGTAEIARELAARVPRVRVIRLSRNfGKGAAVRAGFKAA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340  85 INKFnpylIIQMDADYQHDPERLTEFFEQI-QKGADFVVGTRYSKGGSIpkNWAIHRKILSIGANLFIRLgFMKLKTSEW 163
Cdd:cd04179   79 RGDI----VVTMDADLQHPPEDIPKLLEKLlEGGADVVIGSRFVRGGGA--GMPLLRRLGSRLFNFLIRL-LLGVRISDT 151

                        170       180       190
                 ....*....|....*....|....*....|..
gi 818341340 164 TNGYRAIKTWVIKgALDHIKNYSGYVFQVAMI 195
Cdd:cd04179  152 QSGFRLFRREVLE-ALLSLLESNGFEFGLELL 182
PLN02726 PLN02726
dolichyl-phosphate beta-D-mannosyltransferase
 6-228 4.98e-42

dolichyl-phosphate beta-D-mannosyltransferase


Pssm-ID: 215385 [Multi-domain]  Cd Length: 243  Bit Score: 147.15  E-value: 4.98e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340   6 VILPSFNEAENIAPLIKKIEEINKKLVNWDIniLVVDSYSTDNTGNVVKDLQKTIPTLHIIEVP---KEGLGKAYLRGFN 82
Cdd:PLN02726  13 IIVPTYNERLNIALIVYLIFKALQDVKDFEI--IVVDDGSPDGTQDVVKQLQKVYGEDRILLRPrpgKLGLGTAYIHGLK 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340  83 YAINKFnpylIIQMDADYQHDPERLTEFFE-QIQKGADFVVGTRYSKGGSIpKNWAIHRKILSIGANLFIRLgFMKLKTS 161
Cdd:PLN02726  91 HASGDF----VVIMDADLSHHPKYLPSFIKkQRETGADIVTGTRYVKGGGV-HGWDLRRKLTSRGANVLAQT-LLWPGVS 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 818341340 162 EWTNGYRAIKTWVIKGALDHIKNySGYVFQVAMIDYALKNNAKMSEIPVNFKERKFGISKINASQYV 228
Cdd:PLN02726 165 DLTGSFRLYKRSALEDLVSSVVS-KGYVFQMEIIVRASRKGYRIEEVPITFVDRVYGESKLGGSEIV 230
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 6-220 1.04e-29

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 113.26  E-value: 1.04e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340   6 VILPSFNEAENIAPLIKKIEEINKKlvnwDINILVVDSYSTDNTGNVVKDLQKTIPTLHIIEVPK-EGLGKAYLRGFNYA 84
Cdd:COG0463    6 VVIPTYNEEEYLEEALESLLAQTYP----DFEIIVVDDGSTDGTAEILRELAAKDPRIRVIRLERnRGKGAARNAGLAAA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340  85 INKFnpylIIQMDADYQHDPERLTEFFEQIQK-GADFVVGTRYSKGGSIPknwaiHRKILSIGANLFIRLgfmkLKTSEW 163
Cdd:COG0463   82 RGDY----IAFLDADDQLDPEKLEELVAALEEgPADLVYGSRLIREGESD-----LRRLGSRLFNLVRLL----TNLPDS 148

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 818341340 164 TNGYRAIKtwviKGALDHIKNYSGYVFQVAMIdYALKNNAKMSEIPVNFKERKFGIS 220
Cdd:COG0463  149 TSGFRLFR----REVLEELGFDEGFLEDTELL-RALRHGFRIAEVPVRYRAGESKLN 200
GtrA COG2246
Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose) [Lipid ...
 238-368 2.37e-23

Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose) [Lipid transport and metabolism];


Pssm-ID: 441847  Cd Length: 133  Bit Score: 94.12  E-value: 2.37e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340 238 HSSFIKFVIVGLIGFGVDFGISYLGIQKFHQAVWLITLLSTETAIVSNFILNNFWSFRykkiEGGTGNYLMSFLKFNLVS 317
Cdd:COG2246    7 LRQLLRFGLVGGLGTLVDLGVFYLLVELLGLPPLLANVIAFVVAVIVNFLLNRRWTFR----SRGGRSRLREFLRFLLVS 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 818341340 318 SGSIAIQTIGMQILVGVFGrdLWYLYKILIIAFVIIPYSYILYNKFIWKNK 368
Cdd:COG2246   83 LVGLALNLGLLALLVYVLG--LPYLLAKLIGIVVGTVFNFLLSRRWVFRKK 131
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 6-153 1.03e-20

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 87.84  E-value: 1.03e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340    6 VILPSFNEAENIAPLIKKIEEINKKlvnwDINILVVDSYSTDNTGNVVKDLQKTIPTLHIIEVPK-EGLGKAYLRGFNYA 84
Cdd:pfam00535   2 VIIPTYNEEKYLLETLESLLNQTYP----NFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIRLPEnRGKAGARNAGLRAA 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340   85 inkFNPYLIIqMDADYQHDPERLTEFFEQIQK-GADFVVGTRYSKGGSIPKNWAIHRKILSIGANLFIRL 153
Cdd:pfam00535  78 ---TGDYIAF-LDADDEVPPDWLEKLVEALEEdGADVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLR 143
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 6-185 1.73e-18

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 82.14  E-value: 1.73e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340   6 VILPSFNEAENIAPLIKKIEEINKKLVNwDINILVVDSYSTDNTGNVVKDLQKTIPTLHIIEvpkegL----GK--AYLR 79
Cdd:cd04187    1 IVVPVYNEEENLPELYERLKAVLESLGY-DYEIIFVDDGSTDRTLEILRELAARDPRVKVIR-----LsrnfGQqaALLA 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340  80 GFNYAINKfnpyLIIQMDADYQHDPERLTEFFEQIQKGADFVVGTRYSKGGSipknwaIHRKILSIGANLFIRLgFMKLK 159
Cdd:cd04187   75 GLDHARGD----AVITMDADLQDPPELIPEMLAKWEEGYDVVYGVRKNRKES------WLKRLTSKLFYRLINK-LSGVD 143

                        170       180
                 ....*....|....*....|....*.
gi 818341340 160 TSEWTNGYRAIKTWVIkgalDHIKNY 185
Cdd:cd04187  144 IPDNGGDFRLMDRKVV----DALLLL 165
GtrA pfam04138
GtrA-like protein; Members of this family are predicted to be integral membrane proteins with ...
 243-365 2.26e-17

GtrA-like protein; Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.


Pssm-ID: 427738  Cd Length: 116  Bit Score: 77.20  E-value: 2.26e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340  243 KFVIVGLIGFGVDFGISYLGIQKFHQAVWLITLLSTETAIVSNFILNNFWSFRykkieGGTGNYLMSFLKFNLVSSGSIA 322
Cdd:pfam04138   1 RFLLVGVLGTLVDLAVFLLLLELFGLSYLLANAIAFVVAILVNFLLNRRWTFR-----DRRSGSLRELLRFFLVSLAGLL 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 818341340  323 IQTIGMQILVGVFGRDLWYLYkiLIIAFVIIPYSYILYNKFIW 365
Cdd:pfam04138  76 LNLLLLWLLVDGLGLPPLLAK--LVGIAVGTVVNFLLSRFFVF 116
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 6-214 1.11e-13

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 69.13  E-value: 1.11e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340   6 VILPSFNEAENIAPLIKKIEEINKKLVNWDINILVVDSYSTDNTGNVVKDLQKTIPTLHIIEVPKEGLGKAY-LR-GFNY 83
Cdd:cd04188    1 VVIPAYNEEKRLPPTLEEAVEYLEERPSFSYEIIVVDDGSKDGTAEVARKLARKNPALIRVLTLPKNRGKGGaVRaGMLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340  84 AINKFnpylIIQMDADYQHDPERLTEFFEQI-QKGADFVVGTRYSKGGSIPKNWAIHRKILSIGANLFIRL--------- 153
Cdd:cd04188   81 ARGDY----ILFADADLATPFEELEKLEEALkTSGYDIAIGSRAHLASAAVVKRSWLRNLLGRGFNFLVRLllglgikdt 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 818341340 154 --GFmKLKTSEwtngyraiktwvikgALDHIKNY---SGYVFQVAMIDYALKNNAKMSEIPVNFKE 214
Cdd:cd04188  157 qcGF-KLFTRD---------------AARRLFPRlhlERWAFDVELLVLARRLGYPIEEVPVRWVE 206
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 6-118 7.12e-12

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 65.53  E-value: 7.12e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340   6 VILPSFNEAENIAPLIKKIEEINKKLVNWDIniLVVDSYSTDNTGNVVKDLQKTIPTLHIIEVPKEGlGKAylRGFNYAI 85
Cdd:COG1215   33 VIIPAYNEEAVIEETLRSLLAQDYPKEKLEV--IVVDDGSTDETAEIARELAAEYPRVRVIERPENG-GKA--AALNAGL 107

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 818341340  86 NKFNPYLIIQMDADYQHDP---ERLTEFFEQIQKGA 118
Cdd:COG1215  108 KAARGDIVVFLDADTVLDPdwlRRLVAAFADPGVGA 143
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 6-118 2.83e-11

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 61.86  E-value: 2.83e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340   6 VILPSFNEAENIAPLIKKIEEINKKlvnwDINILVVDSYSTDNTGNVVKDLQKTIPTLHIIEVPKEGLGKAylRGFNYAI 85
Cdd:cd06423    1 IIVPAYNEEAVIERTIESLLALDYP----KLEVIVVDDGSTDDTLEILEELAALYIRRVLVVRDKENGGKA--GALNAGL 74

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 818341340  86 NKFNPYLIIQMDADYQHDP---ERLT-EFFEQIQKGA 118
Cdd:cd06423   75 RHAKGDIVVVLDADTILEPdalKRLVvPFFADPKVGA 111
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 6-143 2.70e-10

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 58.29  E-value: 2.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340   6 VILPSFNEAENIAPLIKKIEEINKKlvnwDINILVVDSYSTDNTGNVVKDLQKT-IPTLHIIEVPKEGLGKAYLRGFNYA 84
Cdd:cd00761    1 VIIPAYNEEPYLERCLESLLAQTYP----NFEVIVVDDGSTDGTLEILEEYAKKdPRVIRVINEENQGLAAARNAGLKAA 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 818341340  85 INKFnpylIIQMDADYQHDPERLTEF--FEQIQKGADFVVGtryskggsiPKNWAIHRKIL 143
Cdd:cd00761   77 RGEY----ILFLDADDLLLPDWLERLvaELLADPEADAVGG---------PGNLLFRRELL 124
PRK10714 PRK10714
undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional
 6-221 3.81e-08

undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional


Pssm-ID: 182669 [Multi-domain]  Cd Length: 325  Bit Score: 54.36  E-value: 3.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340   6 VILPSFNEAENIAPLIKKIEEINKKLVNwDINILVVDSYSTDNTGNVVKDLQKtIPTLHIIEV---PKEGLGKAYLRGFN 82
Cdd:PRK10714  10 VVIPVYNEQESLPELIRRTTAACESLGK-EYEILLIDDGSSDNSAEMLVEAAQ-APDSHIVAIllnRNYGQHSAIMAGFS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340  83 YAINKfnpyLIIQMDADYQHDPERLTEFFEQIQKGADfVVGTRYSKggsipKNWAIHRKILSIGANLFIRLGFMKlKTSE 162
Cdd:PRK10714  88 HVTGD----LIITLDADLQNPPEEIPRLVAKADEGYD-VVGTVRQN-----RQDSWFRKTASKMINRLIQRTTGK-AMGD 156

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 818341340 163 WTNGYRAIKTWVIKGALdHIKNYSGYVFQVAMIdYAlknnAKMSEIPVNFKERKFGISK 221
Cdd:PRK10714 157 YGCMLRAYRRHIVDAML-HCHERSTFIPILANT-FA----RRAIEIPVHHAEREFGDSK 209
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 6-139 3.97e-08

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 53.77  E-value: 3.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340   6 VILPSFNEAENIAPLIKKIeeINKKLVNWDINILVVDSYSTDNTGNVVKDLQKTIPTLHIIEVPKEGLGKaylrGFNYAI 85
Cdd:cd02525    4 IIIPVRNEEKYIEELLESL--LNQSYPKDLIEIIVVDGGSTDGTREIVQEYAAKDPRIRLIDNPKRIQSA----GLNIGI 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 818341340  86 NKFNPYLIIQMDADYQHDPERLTEFFEQIQK-GADFVVGTRYSKGGSiPKNWAIH 139
Cdd:cd02525   78 RNSRGDIIIRVDAHAVYPKDYILELVEALKRtGADNVGGPMETIGES-KFQKAIA 131
GtrA COG2246
Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose) [Lipid ...
 227-295 4.58e-06

Putative flippase GtrA (transmembrane translocase of bactoprenol-linked glucose) [Lipid transport and metabolism];


Pssm-ID: 441847  Cd Length: 133  Bit Score: 45.58  E-value: 4.58e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 818341340 227 YVFQIIQYVLTHSSFIKFVIVGLIGFGVDFGISYLGIQKFHQAVWLITLLSTETAIVSNFILNNFWSFR 295
Cdd:COG2246   61 WTFRSRGGRSRLREFLRFLLVSLVGLALNLGLLALLVYVLGLPYLLAKLIGIVVGTVFNFLLSRRWVFR 129
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 5-109 3.06e-05

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 44.59  E-value: 3.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340   5 VVILpSFNEAENIAPLIKKIEeinkklvNWDINILVVDSYSTDNTGNVVKDLqktipTLHIIEVPKEGLGKAylrgFNYA 84
Cdd:cd02511    4 VVII-TKNEERNIERCLESVK-------WAVDEIIVVDSGSTDRTVEIAKEY-----GAKVYQRWWDGFGAQ----RNFA 66

                         90       100
                 ....*....|....*....|....*.
gi 818341340  85 INKF-NPYLIIqMDADyqhdpERLTE 109
Cdd:cd02511   67 LELAtNDWVLS-LDAD-----ERLTP 86
GtrA pfam04138
GtrA-like protein; Members of this family are predicted to be integral membrane proteins with ...
 241-294 6.63e-05

GtrA-like protein; Members of this family are predicted to be integral membrane proteins with three or four transmembrane spans. They are involved in the synthesis of cell surface polysaccharides. The GtrA family are a subset of this family. GtrA is predicted to be an integral membrane protein with 4 transmembrane spans. It is involved is in O antigen modification by Shigella flexneri bacteriophage X (SfX), but does not determine the specificity of glucosylation. Its function remains unknown, but it may play a role in translocation of undecaprenyl phosphate linked glucose (UndP-Glc) across the cytoplasmic membrane. Another member of this family is a DTDP-glucose-4-keto-6-deoxy-D-glucose reductase, which catalyzes the conversion of dTDP-4-keto-6-deoxy-D-glucose to dTDP-D-fucose, which is involved in the biosynthesis of the serotype-specific polysaccharide antigen of Actinobacillus actinomycetemcomitans Y4 (serotype b). This family also includes the teichoic acid glycosylation protein, GtcA, which is a serotype-specific protein in some Listeria innocua and monocytogenes strains. Its exact function is not known, but it is essential for decoration of cell wall teichoic acids with glucose and galactose.


Pssm-ID: 427738  Cd Length: 116  Bit Score: 41.77  E-value: 6.63e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 818341340  241 FIKFVIVGLIGFGVDFGISYLGIQKFHQAVWLITLLSTETAIVSNFILNNFWSF 294
Cdd:pfam04138  63 LLRFFLVSLAGLLLNLLLLWLLVDGLGLPPLLAKLVGIAVGTVVNFLLSRFFVF 116
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 6-131 1.03e-04

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 43.05  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340   6 VILPSFNEAENIAPLIKKIEEIN--KKLvnwdINILVVDSYSTDNTGNVVKD-LQKTIPTLHIIEVPKEGL-GKAylRGF 81
Cdd:cd04192    1 VVIAARNEAENLPRLLQSLSALDypKEK----FEVILVDDHSTDGTVQILEFaAAKPNFQLKILNNSRVSIsGKK--NAL 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 818341340  82 NYAINKFNPYLIIQMDADYQHDPERLTEFFEQIQKGAD-FVVG-TRYSKGGS 131
Cdd:cd04192   75 TTAIKAAKGDWIVTTDADCVVPSNWLLTFVAFIQKEQIgLVAGpVIYFKGKS 126
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 6-214 1.50e-04

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 43.22  E-value: 1.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340   6 VILPSFNEAENIAPL----IKKIEEINKKLVNWDINILVVDSYSTDNTGNVVKDL----QKTIPTLHIIEVPK-EGLGKA 76
Cdd:PTZ00260  74 IVIPAYNEEDRLPKMlketIKYLESRSRKDPKFKYEIIIVNDGSKDKTLKVAKDFwrqnINPNIDIRLLSLLRnKGKGGA 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340  77 YLRGFNYAINKfnpyLIIQMDADYQ---HDPERLTEFFEQI-QKGADFVVGTR--YSKGGSIPKNwAIHRKILSIGANLF 150
Cdd:PTZ00260 154 VRIGMLASRGK----YILMVDADGAtdiDDFDKLEDIMLKIeQNGLGIVFGSRnhLVDSDVVAKR-KWYRNILMYGFHFI 228

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 818341340 151 IRL-----------GFmKLKTSEWTNgyraiktwVIKGALdHIKNYSgyvFQVAMIDYALKNNAKMSEIPVNFKE 214
Cdd:PTZ00260 229 VNTicgtnlkdtqcGF-KLFTRETAR--------IIFPSL-HLERWA---FDIEIVMIAQKLNLPIAEVPVNWTE 290
glyco_like_mftF TIGR04283
transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it ...
 6-56 1.80e-04

transferase 2, rSAM/selenodomain-associated; This enzyme may transfer a nucleotide, or it sugar moiety, as part of a biosynthetic pathway. Other proposed members of the pathway include another transferase (TIGR04282), a phosphoesterase, and a radical SAM enzyme (TIGR04167) whose C-terminal domain (pfam12345) frequently contains a selenocysteine. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 275103 [Multi-domain]  Cd Length: 220  Bit Score: 42.50  E-value: 1.80e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 818341340    6 VILPSFNEAENIAPLIKKIEEINKklvnwDINILVVDSYSTDNTGNVVKDL 56
Cdd:TIGR04283   3 IIIPVLNEAATLPELLADLQALRG-----DAEVIVVDGGSTDGTVEIARSL 48
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
6-99 1.83e-04

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 42.29  E-value: 1.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340   6 VILPSFNEAENIAPLIKKIeeinKKLVNWDINILVVDSYSTDNTGNVVKDLQktIPTLHIIEVPKE-GLGKAYLRGFNYA 84
Cdd:COG1216    7 VVIPTYNRPELLRRCLESL----LAQTYPPFEVIVVDNGSTDGTAELLAALA--FPRVRVIRNPENlGFAAARNLGLRAA 80

                         90
                 ....*....|....*
gi 818341340  85 InkfNPYLIIqMDAD 99
Cdd:COG1216   81 G---GDYLLF-LDDD 91
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 6-60 3.47e-04

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 41.40  E-value: 3.47e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 818341340   6 VILPSFNEAENIAPLIKKIEEinkkLVNWDINILVVDSYSTDNTGNVVKDLQKTI 60
Cdd:cd02522    3 IIIPTLNEAENLPRLLASLRR----LNPLPLEIIVVDGGSTDGTVAIARSAGVVV 53
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 6-87 1.54e-03

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 39.87  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340   6 VILPSFNEAENIApliKKIEEI------NKKLvnwdiNILVVDSYSTDNTGNVVKDLQKTIPTLHIievPKEGLGKAylr 79
Cdd:cd06439   33 IIIPAYNEEAVIE---AKLENLlaldypRDRL-----EIIVVSDGSTDGTAEIAREYADKGVKLLR---FPERRGKA--- 98


                 ....*...
gi 818341340  80 gfnYAINK 87
Cdd:cd06439   99 ---AALNR 103
EPS_HpsE NF038302
hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;
5-80 2.81e-03

hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;


Pssm-ID: 439602 [Multi-domain]  Cd Length: 307  Bit Score: 39.01  E-value: 2.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340   5 VVIlPSFNEAENIAPLIKKI-EEINKKLVNWDIniLVVDSYSTDNTGNVVKDLQKTIP---TLHIIEVPKEGLGKAYLRG 80
Cdd:NF038302   5 VAI-PTYNGANRLPEVLERLrSQIGTESLSWEI--IVVDNNSTDNTAQVVQEYQKNWPspyPLRYCFEPQQGAAFARQRA 81
PRK13915 PRK13915
putative glucosyl-3-phosphoglycerate synthase; Provisional
 6-49 2.84e-03

putative glucosyl-3-phosphoglycerate synthase; Provisional


Pssm-ID: 237556 [Multi-domain]  Cd Length: 306  Bit Score: 39.13  E-value: 2.84e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 818341340   6 VILPSFNEAENIAPLIKKI-EEINKKLVNwdiNILVVDSYSTDNT 49
Cdd:PRK13915  35 VVLPALNEEETVGKVVDSIrPLLMEPLVD---ELIVIDSGSTDAT 76
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 6-86 5.33e-03

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 38.00  E-value: 5.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 818341340   6 VILPSFNEAENIAPLIKKIeeINKKLVNWdiNILVVDSYSTDNTGNVVKDLQKTIPTLHIIEVPKEGLGkaYLRGFNYAI 85
Cdd:cd04196    2 VLMATYNGEKYLREQLDSI--LAQTYKND--ELIISDDGSTDGTVEIIKEYIDKDPFIIILIRNGKNLG--VARNFESLL 75


                 .
gi 818341340  86 N 86
Cdd:cd04196   76 Q 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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