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Conserved domains on  [gi|825820162|gb|KLJ36124|]
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hypothetical protein WA47_00005, partial [Streptococcus agalactiae]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
strep_RK_lipo super family cl14018
putative cross-wall-targeting lipoprotein signal; The YSIRK signal domain targets proteins to ...
11-39 4.38e-03

putative cross-wall-targeting lipoprotein signal; The YSIRK signal domain targets proteins to the cross-wall, or septum, of dividing Gram-positive bacterial. Lipoprotein signal motifs direct a characteristic N-terminal cleavage and lipid modification for membrane anchoring. This Streptococcal-only signal peptide variant appears to be a hybrid between the two, likely directing protein targeting of nascent surface lipoproteins to the cross-wall. Nearly all members of this family have the characteristic LPXTG cell wall anchor signal at the C-terminus.


The actual alignment was detected with superfamily member TIGR03726:

Pssm-ID: 274751 [Multi-domain]  Cd Length: 34  Bit Score: 32.73  E-value: 4.38e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 825820162   11 FRKSKAYGLVCAIALAGAFTLATS--QVSAD 39
Cdd:TIGR03726   3 FRKSKKYKTLCGAVLGTTVTAATAgtVVHAD 33
 
Name Accession Description Interval E-value
strep_RK_lipo TIGR03726
putative cross-wall-targeting lipoprotein signal; The YSIRK signal domain targets proteins to ...
11-39 4.38e-03

putative cross-wall-targeting lipoprotein signal; The YSIRK signal domain targets proteins to the cross-wall, or septum, of dividing Gram-positive bacterial. Lipoprotein signal motifs direct a characteristic N-terminal cleavage and lipid modification for membrane anchoring. This Streptococcal-only signal peptide variant appears to be a hybrid between the two, likely directing protein targeting of nascent surface lipoproteins to the cross-wall. Nearly all members of this family have the characteristic LPXTG cell wall anchor signal at the C-terminus.


Pssm-ID: 274751 [Multi-domain]  Cd Length: 34  Bit Score: 32.73  E-value: 4.38e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 825820162   11 FRKSKAYGLVCAIALAGAFTLATS--QVSAD 39
Cdd:TIGR03726   3 FRKSKKYKTLCGAVLGTTVTAATAgtVVHAD 33
 
Name Accession Description Interval E-value
strep_RK_lipo TIGR03726
putative cross-wall-targeting lipoprotein signal; The YSIRK signal domain targets proteins to ...
11-39 4.38e-03

putative cross-wall-targeting lipoprotein signal; The YSIRK signal domain targets proteins to the cross-wall, or septum, of dividing Gram-positive bacterial. Lipoprotein signal motifs direct a characteristic N-terminal cleavage and lipid modification for membrane anchoring. This Streptococcal-only signal peptide variant appears to be a hybrid between the two, likely directing protein targeting of nascent surface lipoproteins to the cross-wall. Nearly all members of this family have the characteristic LPXTG cell wall anchor signal at the C-terminus.


Pssm-ID: 274751 [Multi-domain]  Cd Length: 34  Bit Score: 32.73  E-value: 4.38e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 825820162   11 FRKSKAYGLVCAIALAGAFTLATS--QVSAD 39
Cdd:TIGR03726   3 FRKSKKYKTLCGAVLGTTVTAATAgtVVHAD 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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