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Conserved domains on  [gi|830086234|gb|KLS05136|]
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heme biosynthesis protein HemY [Neisseria gonorrhoeae ATL_2011_01_08]

Protein Classification

iron-sulfur cluster assembly accessory protein( domain architecture ID 10020185)

iron-sulfur cluster assembly accessory protein from the HesB/IscA family is involved in the assembly of iron-sulfur proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IscA TIGR02011
iron-sulfur cluster assembly protein IscA; This model represents the IscA component of the ISC ...
 22-126 3.95e-68

iron-sulfur cluster assembly protein IscA; This model represents the IscA component of the ISC system for iron-sulfur cluster assembly. The ISC system consists of IscRASU, HscAB and an Isc-specific ferredoxin. IscA previously was believed to act as a scaffold and now is seen as an iron donor protein. This clade is limited to the proteobacteria. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


:

Pssm-ID: 213674  Cd Length: 105  Bit Score: 200.44  E-value: 3.95e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830086234   22 ITLTENAAKHINDYLAKRGKGLGVRLGVKTSGCSGMAYNLEFVDEANGDDLIFEGHGARIYIDPKSLVYLDGTQVDYTKE 101
Cdd:TIGR02011   1 ITLTDSAAARVNTFLANRGKGFGLRLGVKTSGCSGMAYVLEFVDEPTPDDIVFEDKGVKIVIDGKSLQYLDGTQLDFVKE 80

                          90       100
                  ....*....|....*....|....*
gi 830086234  102 DLQEGFKFENPNVKDSCGCGESFHV 126
Cdd:TIGR02011  81 GLNEGFKFTNPNVKDECGCGESFHV 105
 
Name Accession Description Interval E-value
IscA TIGR02011
iron-sulfur cluster assembly protein IscA; This model represents the IscA component of the ISC ...
 22-126 3.95e-68

iron-sulfur cluster assembly protein IscA; This model represents the IscA component of the ISC system for iron-sulfur cluster assembly. The ISC system consists of IscRASU, HscAB and an Isc-specific ferredoxin. IscA previously was believed to act as a scaffold and now is seen as an iron donor protein. This clade is limited to the proteobacteria. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 213674  Cd Length: 105  Bit Score: 200.44  E-value: 3.95e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830086234   22 ITLTENAAKHINDYLAKRGKGLGVRLGVKTSGCSGMAYNLEFVDEANGDDLIFEGHGARIYIDPKSLVYLDGTQVDYTKE 101
Cdd:TIGR02011   1 ITLTDSAAARVNTFLANRGKGFGLRLGVKTSGCSGMAYVLEFVDEPTPDDIVFEDKGVKIVIDGKSLQYLDGTQLDFVKE 80

                          90       100
                  ....*....|....*....|....*
gi 830086234  102 DLQEGFKFENPNVKDSCGCGESFHV 126
Cdd:TIGR02011  81 GLNEGFKFTNPNVKDECGCGESFHV 105
IscA COG0316
Fe-S cluster assembly iron-binding protein IscA [Posttranslational modification, protein ...
 21-126 9.46e-60

Fe-S cluster assembly iron-binding protein IscA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440085 [Multi-domain]  Cd Length: 107  Bit Score: 179.19  E-value: 9.46e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830086234  21 MITLTENAAKHINDYLAKRG-KGLGVRLGVKTSGCSGMAYNLEFVDEANGDDLIFEGHGARIYIDPKSLVYLDGTQVDYT 99
Cdd:COG0316    1 PITLTDAAAKRIKRLLAKEGnPGLGLRVGVKGGGCSGFSYGLDFDDEPNEDDLVFEQDGVKVVVDPKSLPYLDGTEIDYV 80

                         90       100
                 ....*....|....*....|....*..
gi 830086234 100 KEDLQEGFKFENPNVKDSCGCGESFHV 126
Cdd:COG0316   81 EELLGSGFKFNNPNAKSSCGCGESFSV 107
iscA PRK09502
iron-sulfur cluster assembly protein IscA;
22-126 8.21e-53

iron-sulfur cluster assembly protein IscA;


Pssm-ID: 181914 [Multi-domain]  Cd Length: 107  Bit Score: 161.58  E-value: 8.21e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830086234  22 ITLTENAAKHINDYLAKRGKGLGVRLGVKTSGCSGMAYNLEFVDEANGDDLIFEGHGARIYIDPKSLVYLDGTQVDYTKE 101
Cdd:PRK09502   3 ITLSDSAAARVNTFLANRGKGFGLRLGVRTSGCSGMAYVLEFVDEPTPEDIVFEDKGVKVVVDGKSLQFLDGTQLDFVKE 82

                         90       100
                 ....*....|....*....|....*
gi 830086234 102 DLQEGFKFENPNVKDSCGCGESFHV 126
Cdd:PRK09502  83 GLNEGFKFTNPNVKDECGCGESFHV 107
Fe-S_biosyn pfam01521
Iron-sulphur cluster biosynthesis; This family is involved in iron-sulphur cluster ...
 22-122 6.50e-24

Iron-sulphur cluster biosynthesis; This family is involved in iron-sulphur cluster biosynthesis. Its members include proteins that are involved in nitrogen fixation such as the HesB and HesB-like proteins.


Pssm-ID: 426304  Cd Length: 111  Bit Score: 88.47  E-value: 6.50e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830086234   22 ITLTENAAKHINDYLAKRGKGLgvRLGVKTSG-------CS-GMAYNLEFVDEANGD-DLIFEGHGARIYIDPKSLVYLD 92
Cdd:pfam01521   3 ITITDAAAERLKKLLAGDKKEL--RLDVDDGGgpyskggCSiGGKFSLVLVDEPDPDyDEVIESNGGPIYVDSYSLPFLD 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 830086234   93 -GTQVDYTKEDLQEGFKFENPNVKDSCGCGE 122
Cdd:pfam01521  81 eGLTLDFVEDLGTLGLKSDNGNLDGNVGCGD 111
 
Name Accession Description Interval E-value
IscA TIGR02011
iron-sulfur cluster assembly protein IscA; This model represents the IscA component of the ISC ...
 22-126 3.95e-68

iron-sulfur cluster assembly protein IscA; This model represents the IscA component of the ISC system for iron-sulfur cluster assembly. The ISC system consists of IscRASU, HscAB and an Isc-specific ferredoxin. IscA previously was believed to act as a scaffold and now is seen as an iron donor protein. This clade is limited to the proteobacteria. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 213674  Cd Length: 105  Bit Score: 200.44  E-value: 3.95e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830086234   22 ITLTENAAKHINDYLAKRGKGLGVRLGVKTSGCSGMAYNLEFVDEANGDDLIFEGHGARIYIDPKSLVYLDGTQVDYTKE 101
Cdd:TIGR02011   1 ITLTDSAAARVNTFLANRGKGFGLRLGVKTSGCSGMAYVLEFVDEPTPDDIVFEDKGVKIVIDGKSLQYLDGTQLDFVKE 80

                          90       100
                  ....*....|....*....|....*
gi 830086234  102 DLQEGFKFENPNVKDSCGCGESFHV 126
Cdd:TIGR02011  81 GLNEGFKFTNPNVKDECGCGESFHV 105
IscA COG0316
Fe-S cluster assembly iron-binding protein IscA [Posttranslational modification, protein ...
 21-126 9.46e-60

Fe-S cluster assembly iron-binding protein IscA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440085 [Multi-domain]  Cd Length: 107  Bit Score: 179.19  E-value: 9.46e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830086234  21 MITLTENAAKHINDYLAKRG-KGLGVRLGVKTSGCSGMAYNLEFVDEANGDDLIFEGHGARIYIDPKSLVYLDGTQVDYT 99
Cdd:COG0316    1 PITLTDAAAKRIKRLLAKEGnPGLGLRVGVKGGGCSGFSYGLDFDDEPNEDDLVFEQDGVKVVVDPKSLPYLDGTEIDYV 80

                         90       100
                 ....*....|....*....|....*..
gi 830086234 100 KEDLQEGFKFENPNVKDSCGCGESFHV 126
Cdd:COG0316   81 EELLGSGFKFNNPNAKSSCGCGESFSV 107
TIGR00049 TIGR00049
Iron-sulfur cluster assembly accessory protein; Proteins in this subfamily appear to be ...
 23-126 6.49e-53

Iron-sulfur cluster assembly accessory protein; Proteins in this subfamily appear to be associated with the process of FeS-cluster assembly. The HesB proteins are associated with the nif gene cluster and the Rhizobium gene IscN has been shown to be required for nitrogen fixation. Nitrogenase includes multiple FeS clusters and many genes for their assembly. The E. coli SufA protein is associated with SufS, a NifS homolog and SufD which are involved in the FeS cluster assembly of the FhnF protein. The Azotobacter protein IscA (homologs of which are also found in E.coli) is associated which IscS, another NifS homolog and IscU, a nifU homolog as well as other factors consistent with a role in FeS cluster chemistry. A homolog from Geobacter contains a selenocysteine in place of an otherwise invariant cysteine, further suggesting a role in redox chemistry. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 272875 [Multi-domain]  Cd Length: 105  Bit Score: 161.59  E-value: 6.49e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830086234   23 TLTENAAKHINDYLAKRGK-GLGVRLGVKTSGCSGMAYNLEFVDEANGDDLIFEGHGARIYIDPKSLVYLDGTQVDYTKE 101
Cdd:TIGR00049   1 TLTDSAAKRIKALLAGEGEpNLGLRVGVKGGGCSGLQYGLEFDDEPNEDDEVFEQDGVKVVVDPKSLPYLDGSEIDYVEE 80

                          90       100
                  ....*....|....*....|....*
gi 830086234  102 DLQEGFKFENPNVKDSCGCGESFHV 126
Cdd:TIGR00049  81 LLGSGFTFTNPNAKGTCGCGKSFSV 105
iscA PRK09502
iron-sulfur cluster assembly protein IscA;
22-126 8.21e-53

iron-sulfur cluster assembly protein IscA;


Pssm-ID: 181914 [Multi-domain]  Cd Length: 107  Bit Score: 161.58  E-value: 8.21e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830086234  22 ITLTENAAKHINDYLAKRGKGLGVRLGVKTSGCSGMAYNLEFVDEANGDDLIFEGHGARIYIDPKSLVYLDGTQVDYTKE 101
Cdd:PRK09502   3 ITLSDSAAARVNTFLANRGKGFGLRLGVRTSGCSGMAYVLEFVDEPTPEDIVFEDKGVKVVVDGKSLQFLDGTQLDFVKE 82

                         90       100
                 ....*....|....*....|....*
gi 830086234 102 DLQEGFKFENPNVKDSCGCGESFHV 126
Cdd:PRK09502  83 GLNEGFKFTNPNVKDECGCGESFHV 107
sufA_proteo TIGR01997
FeS assembly scaffold SufA; This model represents the SufA protein of the SUF system of ...
 22-126 6.54e-44

FeS assembly scaffold SufA; This model represents the SufA protein of the SUF system of iron-sulfur cluster biosynthesis. This system performs FeS biosynthesis even during oxidative stress and tends to be absent in obligate anaerobic and microaerophilic bacteria. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 131052  Cd Length: 107  Bit Score: 139.19  E-value: 6.54e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830086234   22 ITLTENAAKHINDYLAKRGKGLGVRLGVKTSGCSGMAYNLEFVDEANGDDLIFEGHGARIYIDPKSLVYLDGTQVDYTKE 101
Cdd:TIGR01997   3 ITLTDAAAIHIRELVAKRPEAVGIRLGVKKTGCAGMEYVLDLVSEPKKDDDLIEHDGAKVFVAPEAVLFILGTQVDFVRT 82

                          90       100
                  ....*....|....*....|....*
gi 830086234  102 DLQEGFKFENPNVKDSCGCGESFHV 126
Cdd:TIGR01997  83 TLRQGFKFNNPNATSACGCGESFEL 107
sufA PRK09504
iron-sulfur cluster assembly scaffold protein; Provisional
 22-126 1.31e-39

iron-sulfur cluster assembly scaffold protein; Provisional


Pssm-ID: 181915  Cd Length: 122  Bit Score: 128.70  E-value: 1.31e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830086234  22 ITLTENAAKHINDYLAKRGKGLGVRLGVKTSGCSGMAYNLEFVDEANGDDLIFEGHGARIYIDPKSLVYLDGTQVDYTKE 101
Cdd:PRK09504  18 LTLTPAAAAHIRELMAKQPGMKGVRLGVKQTGCAGFGYVLDSVSEPDKDDLVFEHDGAKLFVPLQAMPFIDGTEVDYVRE 97

                         90       100
                 ....*....|....*....|....*
gi 830086234 102 DLQEGFKFENPNVKDSCGCGESFHV 126
Cdd:PRK09504  98 GLNQIFKFHNPKAQNECGCGESFGV 122
Fe-S_biosyn pfam01521
Iron-sulphur cluster biosynthesis; This family is involved in iron-sulphur cluster ...
 22-122 6.50e-24

Iron-sulphur cluster biosynthesis; This family is involved in iron-sulphur cluster biosynthesis. Its members include proteins that are involved in nitrogen fixation such as the HesB and HesB-like proteins.


Pssm-ID: 426304  Cd Length: 111  Bit Score: 88.47  E-value: 6.50e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830086234   22 ITLTENAAKHINDYLAKRGKGLgvRLGVKTSG-------CS-GMAYNLEFVDEANGD-DLIFEGHGARIYIDPKSLVYLD 92
Cdd:pfam01521   3 ITITDAAAERLKKLLAGDKKEL--RLDVDDGGgpyskggCSiGGKFSLVLVDEPDPDyDEVIESNGGPIYVDSYSLPFLD 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 830086234   93 -GTQVDYTKEDLQEGFKFENPNVKDSCGCGE 122
Cdd:pfam01521  81 eGLTLDFVEDLGTLGLKSDNGNLDGNVGCGD 111
PRK13623 PRK13623
iron-sulfur cluster insertion protein ErpA; Provisional
 22-126 9.39e-24

iron-sulfur cluster insertion protein ErpA; Provisional


Pssm-ID: 184186  Cd Length: 115  Bit Score: 88.06  E-value: 9.39e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830086234  22 ITLTENAAKHINDYLAKRGKG-LGVRLGVKTSGCSGMAYNLEFVDEANGDDLIFEGHGARIYIDPKSLVYLDGTQVDYTk 100
Cdd:PRK13623  10 LVFTDAAAAKVKELIEEEGNPdLKLRVYITGGGCSGFQYGFTFDEQVNEDDTTIEKQGVTLVVDPMSLQYLVGAEVDYT- 88

                         90       100
                 ....*....|....*....|....*...
gi 830086234 101 EDLqEGFKF--ENPNVKDSCGCGESFHV 126
Cdd:PRK13623  89 EGL-EGSRFviKNPNAKTTCGCGSSFSI 115
PLN03082 PLN03082
Iron-sulfur cluster assembly; Provisional
 7-126 6.02e-19

Iron-sulfur cluster assembly; Provisional


Pssm-ID: 215564  Cd Length: 163  Bit Score: 77.27  E-value: 6.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830086234   7 AASDPSGAVQQGRNMITLTENAAKHINDYLAKRG--KGLGVRLGVKTSGCSGMAYNLEFVDEANGDDLIFEGHGARIYID 84
Cdd:PLN03082  40 STSSSSPSSSASLDAVHMTDNCIRRLKELQTSEPsaEDKMLRLSVETGGCSGFQYVFELDDKTNSDDRVFEKDGVKLVVD 119

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 830086234  85 PKSLVYLDGTQVDYTKEDLQEGFKF-ENPNVKDSCGCGESFHV 126
Cdd:PLN03082 120 NISYDFVKGATVDYVEELIRSAFVVsTNPSAVGGCSCKSSFMV 162
PRK11190 PRK11190
iron-sulfur cluster biogenesis protein NfuA;
21-115 1.26e-06

iron-sulfur cluster biogenesis protein NfuA;


Pssm-ID: 183027 [Multi-domain]  Cd Length: 192  Bit Score: 45.01  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830086234  21 MITLTENAAKHINDYLAKRGKGLGVRL-----GVKTSGCsGMAYNLEFVDEANGDDLIFEGHGAriYIDPKSLVYLDGTQ 95
Cdd:PRK11190   1 MITISDAAQAHFAKLLANQEEGTQIRVfvinpGTPNAEC-GVSYCPPDAVEATDTELKFDGFSA--YVDELSAPFLEDAE 77

                         90       100
                 ....*....|....*....|
gi 830086234  96 VDYTKEDLQEGFKFENPNVK 115
Cdd:PRK11190  78 IDFVTDQLGSQLTLKAPNAK 97
YqkB COG4918
Predicted Fe-S cluster biosynthesis protein YqkB [General function prediction only];
22-98 3.31e-03

Predicted Fe-S cluster biosynthesis protein YqkB [General function prediction only];


Pssm-ID: 443946  Cd Length: 112  Bit Score: 34.92  E-value: 3.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830086234  22 ITLTENAAKHINDYLAKRGKGLgvRLGVKTSGCS-GMA--YNLEFVDEANGDDLIFEGHGARIYIDPKSLVYLDGT-QVD 97
Cdd:COG4918    3 ITFTEAAKEKLQAILGSDKKYL--KLFYDTEGCGcAVNgvPTLRLVDEPDEYDTAIESNLGPVYIDRSQEVFFDDEmTID 80


                 .
gi 830086234  98 Y 98
Cdd:COG4918   81 F 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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