|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
8-362 |
0e+00 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 581.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 8 TWTMRHRLLLTIGAILVVCQLISVFWLWHESKEQIQLLVASAIEGHNNQKHVEHEVREAVASLLVPSLLIVGLALYISML 87
Cdd:PRK10755 1 MISLRRRLLLTIGLILLVFQLISVFWLWHESTEQIQLLVQATLSARNNDEHVMKEIREAVASLLVPSLVMVSLTLLICFQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 88 AVRKITRPLSRLQSELENRTPDNLTPIVLSESVPEVTAVTTALNQLVSRLNLTLDRERLFTADVAHELRTPLAGLRLHLE 167
Cdd:PRK10755 81 AVRWITRPLAELQKELEARTADNLTPIAIHSSTLEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLHLE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 168 LLAKVHGMGVDPLIQRLDQMTTSISQLLQLARVGQSFSAGSYQQVLLLDDVVKPLQDELEAMLAQRQQRLLLTDIENEAV 247
Cdd:PRK10755 161 LLEKQHHIDVAPLIARLDQMMHTVEQLLQLARAGQSFSSGHYQTVKLLEDVILPSQDELSEMLEQRQQTLLLPESAADIT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 248 VSGDATLIGVILRNLVENAHRYSPEGSTIRVSV-KAGLMPVMAVEDEGPGIDEAKSGELSKAFVRMDSRYGGIGLGLSIV 326
Cdd:PRK10755 241 VQGDATLLRLLLRNLVENAHRYSPEGSTITIKLsQEDGGAVLAVEDEGPGIDESKCGELSKAFVRMDSRYGGIGLGLSIV 320
|
330 340 350
....*....|....*....|....*....|....*.
gi 839658588 327 TRIAQLHDAQFFLHNRQPGPGVRAWVLFPQRGGQNV 362
Cdd:PRK10755 321 SRITQLHHGQFFLQNRQERSGTRAWVWLPKAQNVAN 356
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
62-355 |
1.13e-42 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 151.21 E-value: 1.13e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 62 EVREAVASLLVPSLLIVGLALYISMLAVRKITRPLSRLQSELENRTPDNLTPIVLSESVPEVTAVTTALNQLVSRLNLTL 141
Cdd:COG0642 28 LLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEAN 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 142 DRERLFTADVAHELRTPLAGLRLHLELLAKVHGMGVDPLIQRL----DQMTTSISQLLQLARVGQSFSAGSYQQVLLlDD 217
Cdd:COG0642 108 EAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETIlrsaDRLLRLINDLLDLSRLEAGKLELEPEPVDL-AE 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 218 VVKPLQDELEAMLAQRQQRLLLTDIENEAVVSGDATLIGVILRNLVENAHRYSPEGSTIRVSVKA-GLMPVMAVEDEGPG 296
Cdd:COG0642 187 LLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVRReGDRVRISVEDTGPG 266
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 839658588 297 IDEAKSGELSKAFVRMDS--RYGGIGLGLSIVTRIAQLHDAQFFLHNRqPGPGVRAWVLFP 355
Cdd:COG0642 267 IPPEDLERIFEPFFRTDPsrRGGGTGLGLAIVKRIVELHGGTIEVESE-PGKGTTFTVTLP 326
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
129-355 |
6.55e-41 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 143.89 E-value: 6.55e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 129 ALNQLVSRLNLTLDRERLFTADVAHELRTPLAGLRLHLELLAKVHGMGVDPLIQRLDQMTTS-------ISQLLQLARVg 201
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRELLEIIRESaerllrlIEDLLDLSRL- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 202 qsfSAGSYQ---QVLLLDDVVKPLQDELEAMLAQRQQRLLLTDIENEAVVSGDATLIGVILRNLVENAHRYSPEGSTIRV 278
Cdd:COG2205 80 ---ESGKLSlelEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 279 SVK-AGLMPVMAVEDEGPGIDEAKSGELSKAFVRMDS--RYGGIGLGLSIVTRIAQLHDAQFFLHNRqPGPGVRAWVLFP 355
Cdd:COG2205 157 SARrEGDGVRISVSDNGPGIPEEELERIFERFYRGDNsrGEGGTGLGLAIVKRIVEAHGGTIWVESE-PGGGTTFTVTLP 235
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
67-352 |
2.39e-40 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 147.87 E-value: 2.39e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 67 VASLLVPSLLIVGLALYISMLAVRKITRPLSRLQSELENRTPDNLTPIVlSESVP-EVTAVTTALNQLVSRLNLTLDRER 145
Cdd:PRK10337 160 VAGQLIPWLVALPIMLIILMVLLGRELAPLKKLALALRMRDPDSETPLN-ATGVPsEVRPLVEALNQLFARTHAMMVRER 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 146 LFTADVAHELRTPLAGLRLHLELLAKVHGmgvDPLIQR--LDQMTTSIS-------QLLQLARVGQSFSAGSYQQVlLLD 216
Cdd:PRK10337 239 RFTSDAAHELRSPLAALKVQTEVAQLSDD---DPQARKkaLLQLHAGIDratrlvdQLLTLSRLDSLDNLQDVAEI-PLE 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 217 DVvkpLQDELEAML--AQRQQRLLLTDIENEAVV-SGDATLIGVILRNLVENAHRYSPEGSTIRVSVKAGLmpvMAVEDE 293
Cdd:PRK10337 315 DL---LQSAVMDIYhtAQQAGIDVRLTLNAHPVIrTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNARN---FTVRDN 388
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 294 GPGIDEAKSGELSKAFVRMDSR-YGGIGLGLSIVTRIAQLHDAQFFLHNRqPGPGVRAWV 352
Cdd:PRK10337 389 GPGVTPEALARIGERFYRPPGQeATGSGLGLSIVRRIAKLHGMNVSFGNA-PEGGFEAKV 447
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
1-355 |
4.00e-40 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 145.85 E-value: 4.00e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 1 MALFATETWTMRHRLLLTIGAILVVCQLISVFWLWHESKEQIQLLVASAIEGHNNQKHVEHEVREAVASLLVPSLLIVGL 80
Cdd:COG5002 20 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 81 ALYI--SMLAVRKITRPLSRLQSELENRTPDNLTPIVLSESVPEVTAVTTALNQLVSRLNLTLDRERLFTADVAHELRTP 158
Cdd:COG5002 100 ALLIllLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 159 LAGLRLHLELLAkvHGMGVDPLIQR---------LDQMTTSISQLLQLARvgqsFSAGSYQ---QVLLLDDVVKPLQDEL 226
Cdd:COG5002 180 LTSIRGYLELLL--DGAADDPEERReyleiileeAERLSRLVNDLLDLSR----LESGELKlekEPVDLAELLEEVVEEL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 227 EAMLAQRQQRLLLTDIENEAVVSGDATLIGVILRNLVENAHRYSPEGSTIRVSVKA-GLMPVMAVEDEGPGIDEAKSGEL 305
Cdd:COG5002 254 RPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLREeDDQVRISVRDTGIGIPEEDLPRI 333
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 839658588 306 SKAFVRMDS----RYGGIGLGLSIVTRIAQLHDAQFFLHNrQPGPGVRAWVLFP 355
Cdd:COG5002 334 FERFYRVDKsrsrETGGTGLGLAIVKHIVEAHGGRIWVES-EPGKGTTFTITLP 386
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
248-354 |
3.78e-37 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 129.83 E-value: 3.78e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 248 VSGDATLIGVILRNLVENAHRYSPEGSTIRVSVKAGLMPVMAVEDEGPGIDEAKSGELSKAFVRMDSR-YGGIGLGLSIV 326
Cdd:cd16940 7 VQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDGAVIRVEDNGPGIDEEELEALFERFYRSDGQnYGGSGLGLSIV 86
|
90 100
....*....|....*....|....*...
gi 839658588 327 TRIAQLHDAQFFLHNRqPGPGVRAWVLF 354
Cdd:cd16940 87 KRIVELHGGQIFLGNA-QGGGLEAWVRL 113
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
74-358 |
6.14e-27 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 111.09 E-value: 6.14e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 74 SLLIVGLALYISMLAVRKITRPLSRLQ---SELENRTPDNLTPIvlseSVPEVTAVTTALNQLVSRL-----------NL 139
Cdd:PRK11100 188 GALLLGIALLIGAGVVWWLNRSIRRLTryaDAVTEGKPVPLPKL----GSSELRELAQALESMRVKLegkayveqyvqTL 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 140 TldrerlftadvaHELRTPLAGLRLHLELLAKvhGMGVDPLIQRLDQ-------MTTSISQLLQLARVGQSFSAGSYQQV 212
Cdd:PRK11100 264 T------------HELKSPLAAIRGAAELLQE--DPPPEDRARFTGNiltqsarLQQLIDRLLELARLEQRQELEVLEPV 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 213 LLlDDVVKPLQDELEAMLAQRQQRLLLTdiENEAVVSGDATLIGVILRNLVENAHRYSPEGSTIRVSV-KAGLMPVMAVE 291
Cdd:PRK11100 330 AL-AALLEELVEAREAQAAAKGITLRLR--PDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAeVDGEQVALSVE 406
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 839658588 292 DEGPGI-DEAksgeLSKAF------VRMDSRYGGIGLGLSIVTRIAQLHDAQFFLHNRQPGpGVRAWVLFPQRG 358
Cdd:PRK11100 407 DQGPGIpDYA----LPRIFerfyslPRPANGRKSTGLGLAFVREVARLHGGEVTLRNRPEG-GVLATLTLPRHF 475
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
134-336 |
5.57e-26 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 106.14 E-value: 5.57e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 134 VSRLNLTLDRERLFTADVAHELRTPLAGLRLHLELLAKvhGMGVDPLIQR------LDQ---MTTSISQLLQLARVgQSF 204
Cdd:TIGR02966 104 VTRLRRLEQMRRDFVANVSHELRTPLTVLRGYLETLAD--GPDEDPEEWNraleimLEQsqrMQSLVEDLLTLSRL-ESA 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 205 SAGSYQQVLLLDDVVKPLQDELEAMLAQRQQRLLLtDIENEAVVSGDATLIGVILRNLVENAHRYSPEGSTIRVS-VKAG 283
Cdd:TIGR02966 181 ASPLEDEPVDMPALLDHLRDEAEALSQGKNHQITF-EIDGGVDVLGDEDELRSAFSNLVSNAIKYTPEGGTITVRwRRDG 259
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 839658588 284 LMPVMAVEDEGPGIDEAKSGELSKAFVRMD---SR-YGGIGLGLSIVTRIAQLHDAQ 336
Cdd:TIGR02966 260 GGAEFSVTDTGIGIAPEHLPRLTERFYRVDksrSRdTGGTGLGLAIVKHVLSRHHAR 316
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
40-355 |
1.79e-25 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 106.70 E-value: 1.79e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 40 EQIQLLVASAIEGHnnqkhveHEVREAVAS-LLVPSLLIVGLALYISMLAVRKITRPLSRLQSELENRTPDNL-TPIVLS 117
Cdd:TIGR01386 142 KPVQITVALDINAH-------THLLDALRKwLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLdQRLDPS 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 118 ESVPEVTAVTTALNQLVSRLNLTLDRERLFTADVAHELRTPLAGLRLHLELLAKVHGMG---VDPL---IQRLDQMTTSI 191
Cdd:TIGR01386 215 RAPAELRELAQSFNAMLGRLEDAFQRLSQFSADLAHELRTPLTNLLGQTQVALSQPRTGeeyREVLesnLEELERLSRMV 294
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 192 SQLLQLARVGQSFSAGSYQQVLLLDDVVKpLQDELEAMLAQRQQRLlltDIENEAVVSGDATLIGVILRNLVENAHRYSP 271
Cdd:TIGR01386 295 SDMLFLARADNGQLALERVRLDLAAELAK-VAEYFEPLAEERGVRI---RVEGEGLVRGDPQMFRRAISNLLSNALRHTP 370
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 272 EGSTIRVSV-KAGLMPVMAVEDEGPGIDEAKSGELSKAFVRMD-SRYG---GIGLGLSIVTRIAQLHDAQFFLHnrQPGP 346
Cdd:TIGR01386 371 DGGTITVRIeRRSDEVRVSVSNPGPGIPPEHLSRLFDRFYRVDpARSNsgeGTGLGLAIVRSIMEAHGGRASAE--SPDG 448
|
....*....
gi 839658588 347 GVRAWVLFP 355
Cdd:TIGR01386 449 KTRFILRFP 457
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
70-355 |
1.10e-24 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 104.22 E-value: 1.10e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 70 LLVPSLLIVGLAlyisMLAVRKITRPLSRLQSELEN----RTPDnltPIVLSESVpEVTAVTTALNQLVSRLNLTLDRER 145
Cdd:PRK09467 159 TLAIGLLSVAGG----WLFIRIQNRPLVALEHAALQvgkgEIPP---PLREYGAS-EVRSVTRAFNQMAAGIKQLEDDRT 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 146 LFTADVAHELRTPLAGLRLHLELLAKVHGMGVDPLIQRLDQMTTSISQLLQLARVGQSFSAGSYQQVLLLDDVVkplQDE 225
Cdd:PRK09467 231 LLMAGVSHDLRTPLTRIRLATEMMSEEDGYLAESINKDIEECNAIIEQFIDYLRTGQEMPMEMADLNALLGEVI---AAE 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 226 LEAmlaQRQQRLLLTDIENEAVVSGDAtlIGVILRNLVENAHRYSpeGSTIRVSVKAGLMPV-MAVEDEGPGIDEAKSGE 304
Cdd:PRK09467 308 SGY---EREIETALQPGPIEVPMNPIA--IKRALANLVVNAARYG--NGWIKVSSGTEGKRAwFQVEDDGPGIPPEQLKH 380
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 839658588 305 LSKAFVRMDSRYG--GIGLGLSIVTRIAQLHDAQFFLHNRQPGpGVRAWVLFP 355
Cdd:PRK09467 381 LFQPFTRGDSARGssGTGLGLAIVKRIVDQHNGKVELGNSEEG-GLSARAWLP 432
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
74-355 |
7.52e-24 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 102.21 E-value: 7.52e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 74 SLLIVGLALYISMLAV----RKITRPLSRLQSELENRTPDNLTPIVLSESVPEVTAVTTALNQLVSRLNLTLDRERLFTA 149
Cdd:NF012163 166 SWLIVALALLLAALAAfllaRGLLAPVKRLVEATHRLAAGDYTTRVTPTSNDELGKLAQDFNQLASTLEKNEQMRRDFMA 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 150 DVAHELRTPLAGLRLHLELLAKvhgmGVDPLI-QRLDQMTTSISQLLQ----LARVGQSFSAG-SYQQVLLldDVVKPLQ 223
Cdd:NF012163 246 DISHELRTPLAVLRAELEAIQD----GIRKFTpESLDSLQAEVGTLTKlvddLHDLSMSDEGAlAYQKASV--DLVPLLE 319
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 224 DELEAM---LAQRQQRLLLtDIENEAVVSGDATLIGVILRNLVENAHRYSPEGSTIRVSV-KAGLMPVMAVEDEGPGIDE 299
Cdd:NF012163 320 VEGGAFrerFASAGLELEV-SLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSGGSLHISAsQRPKEVTLTVADSAPGVSD 398
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 839658588 300 AKSGELSKAFVRMDSRY----GGIGLGLSIVTRIAQLHDAQF-FLHNrqPGPGVRAWVLFP 355
Cdd:NF012163 399 EQLARLFERFYRVEVSRnrasGGSGLGLAISLNIVQAHGGTLhAAHS--PLGGLRIVVTLP 457
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
122-333 |
5.12e-23 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 99.62 E-value: 5.12e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 122 EVTAVTTALNQLVSRLN-LTLDRERLFTaDVAHELRTPLAGLRLHLELLAKVHGMG-----VDPLIQRLDQMttsISQLL 195
Cdd:PRK09470 221 EFRQAGASFNQMVTALErMMTSQQRLLS-DISHELRTPLTRLQLATALLRRRQGESkelerIETEAQRLDSM---INDLL 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 196 QLAR-------VGQSFSAGSyqqvlLLDDVVKPLQDELEamlaQRQQRLLLTDIENEAVVSGDATLIGVILRNLVENAHR 268
Cdd:PRK09470 297 VLSRnqqknhlERETFKANS-----LWSEVLEDAKFEAE----QMGKSLTVSAPPGPWPINGNPNALASALENIVRNALR 367
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 839658588 269 YSpeGSTIRVSVKA---GLMpvMAVEDEGPGIDEAKSGELSKAFVRMDS----RYGGIGLGLSIVTRIAQLH 333
Cdd:PRK09470 368 YS--HTKIEVAFSVdkdGLT--ITVDDDGPGVPEEEREQIFRPFYRVDEardrESGGTGLGLAIVENAIQQH 435
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
58-333 |
2.38e-22 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 97.93 E-value: 2.38e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 58 HVEHEVREAVASLLVPSLLIVGLALYISMLAVRKITRPLSRLQSELENRTPDNLTPIVLSESVPEVTAVTTALNQLVSRL 137
Cdd:COG4251 196 LLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAEL 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 138 ---NLTLDRerlFTADVAHELRTPLAGLRLHLELLAKVHGMGVDP--------LIQRLDQMTTSISQLLQLARVGQSfsA 206
Cdd:COG4251 276 ersNEELEQ---FAYVASHDLREPLRKISGFSQLLEEDYGDKLDEegreylerIRDAAERMQALIDDLLAYSRVGRQ--E 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 207 GSYQQVLLlDDVVKPLQDELEAMLAQRQQRLlltDIENEAVVSGDATLIGVILRNLVENAHRYSPEGSTIRVSVKA---G 283
Cdd:COG4251 351 LEFEPVDL-NELLEEVLEDLEPRIEERGAEI---EVGPLPTVRGDPTLLRQVFQNLISNAIKYSRPGEPPRIEIGAereG 426
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 839658588 284 LMPVMAVEDEGPGIDEAKSGELSKAFVRMDSR--YGGIGLGLSIVTRIAQLH 333
Cdd:COG4251 427 GEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRdeYEGTGIGLAIVKKIVERH 478
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
151-355 |
2.54e-22 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 97.34 E-value: 2.54e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 151 VAHELRTPLAGLRLHLELLAKVHGMGVDPLIQRLDQMT-TSISQLLQLARVGQSFSAGSYQ-----QVLLLDDVVKPLQD 224
Cdd:COG5000 208 IAHEIKNPLTPIQLSAERLRRKLADKLEEDREDLERALdTIIRQVDRLKRIVDEFLDFARLpepqlEPVDLNELLREVLA 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 225 ELEAMLAQRQQRLLLTDIENEAVVSGDATLIGVILRNLVENAHRYSPEGSTIRVSVKA-GLMPVMAVEDEGPGIDEAksg 303
Cdd:COG5000 288 LYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRReDGRVRIEVSDNGPGIPEE--- 364
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 839658588 304 ELSKAFVR-MDSRYGGIGLGLSIVTRIAQLHDAQFFLHNRqPGPGVRAWVLFP 355
Cdd:COG5000 365 VLERIFEPfFTTKPKGTGLGLAIVKKIVEEHGGTIELESR-PGGGTTFTIRLP 416
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
129-333 |
6.78e-21 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 93.13 E-value: 6.78e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 129 ALNQLVSRLNLTLDRERLFTADVAHELRTPLAGLRLHLELLAKVHGMGVDPLIQRLDQMTTSISQLLQLARVGQsfsags 208
Cdd:PRK10604 197 AFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSDNLSAAESQALNRDIGQLEALIEELLTYARLDR------ 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 209 yQQV-LLLDDVVKP--LQDELEAMLAQRQQRLLLTDIENEA-VVSGDATLIGVILRNLVENAHRYSpeGSTIRVSV-KAG 283
Cdd:PRK10604 271 -PQNeLHLSEPDLPawLSTHLADIQAVTPEKTVRLDTPHQGdYGALDMRLMERVLDNLLNNALRYA--HSRVRVSLlLDG 347
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 839658588 284 LMPVMAVEDEGPGIDEAKSGELSKAFVRMD-SR---YGGIGLGLSIVTRIAQLH 333
Cdd:PRK10604 348 NQACLIVEDDGPGIPPEERERVFEPFVRLDpSRdraTGGCGLGLAIVHSIALAM 401
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
250-355 |
1.65e-20 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 85.50 E-value: 1.65e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 250 GDATLIGVILRNLVENAHRYSPEGSTIRVSVKAGLMPVMAVEDEGPGIDEAKSGELSKAFVRMDSR-YGGIGLGLSIVTR 328
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADKRgGGGTGLGLSIVRK 80
|
90 100
....*....|....*....|....*..
gi 839658588 329 IAQLHDAQFFLHNRqPGPGVRAWVLFP 355
Cdd:pfam02518 81 LVELLGGTITVESE-PGGGTTVTLTLP 106
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
250-357 |
3.41e-20 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 84.62 E-value: 3.41e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 250 GDATLIGVILRNLVENAHRYSPEGSTIRVSVKAGLMPV-MAVEDEGPGIDEAKSGELSKAFVRMD---SRYGGIGLGLSI 325
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVeITVEDNGPGIPPEDLEKIFEPFFRTDkrsRKIGGTGLGLSI 80
|
90 100 110
....*....|....*....|....*....|..
gi 839658588 326 VTRIAQLHDAQFFLHNRqPGPGVRAWVLFPQR 357
Cdd:smart00387 81 VKKLVELHGGEISVESE-PGGGTTFTITLPLE 111
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
145-357 |
7.69e-20 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 90.07 E-value: 7.69e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 145 RLFTADVAHELRTPLAGLRLHLELL----------AKVHGMgvdpLIQRLDQMTTSISQLLQLARVGQSfsagsyqQVLL 214
Cdd:PRK11006 205 RNFFANVSHELRTPLTVLQGYLEMMqdqplegalrEKALHT----MREQTQRMEGLVKQLLTLSKIEAA-------PTID 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 215 LDDVV------KPLQDELEAmLAQRQQRLLLtDIENEAVVSGDATLIGVILRNLVENAHRYSPEGSTIRVS---VKAGlm 285
Cdd:PRK11006 274 LNEKVdvpmmlRVLEREAQT-LSQGKHTITF-EVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRwqrVPQG-- 349
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 839658588 286 PVMAVEDEGPGIDEAKSGELSKAFVRMD---SRY-GGIGLGLSIVTRIAQLHDAQFFLHNrQPGPGVRAWVLFPQR 357
Cdd:PRK11006 350 AEFSVEDNGPGIAPEHIPRLTERFYRVDkarSRQtGGSGLGLAIVKHALSHHDSRLEIES-EVGKGTRFSFVLPER 424
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
44-336 |
1.04e-18 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 87.13 E-value: 1.04e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 44 LLVASAIEGHnnqkhvEHEVREAVASLLVPSLLIVGLALYISMLAVRKITRPLSRLQSELENRTPDNLTPIVLSESVP-E 122
Cdd:PRK09835 167 LLIALSIDFH------LHYINDLKNKLIMTASVISLLIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPiE 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 123 VTAVTTALNQLVSRLNLTLDRERLFTADVAHELRTPLAGLRLHLELL---AKVHGMGVDPLIQRLDQ---MTTSISQLLQ 196
Cdd:PRK09835 241 LEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIAlsqSRSQKELEDVLYSNLEEltrMAKMVSDMLF 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 197 LARVGQSFSAGSYQQVLLLDDVVKPLqDELEAMLAQRQQRLLLTDieNEAVVSGDATLIGVILRNLVENAHRYSPEGSTI 276
Cdd:PRK09835 321 LAQADNNQLIPEKKMLDLADEVGKVF-DFFEAWAEERGVELRFVG--DPCQVAGDPLMLRRAISNLLSNALRYTPAGEAI 397
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 839658588 277 RVSVKAGLMPV-MAVEDEGPGIDEAKSGELSKAFVRMD---SRYG-GIGLGLSIVTRIAQLHDAQ 336
Cdd:PRK09835 398 TVRCQEVDHQVqLVVENPGTPIAPEHLPRLFDRFYRVDpsrQRKGeGSGIGLAIVKSIVVAHKGT 462
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
69-364 |
7.36e-17 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 81.61 E-value: 7.36e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 69 SLLVPSLLIVGLALYISMLAVRKITRPLSRLQselenRTPDNLTPIVLSESVP-----EVTAVTTALNQLVSRLNLTLDR 143
Cdd:NF040691 189 TLLLGGLALVVLLGLIAWLVTRQVVAPVRSAA-----RTAERFAAGDLSERMPvkgedDLARLARSFNQMADSLQRQIRQ 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 144 -------ERLFTADVAHELRTPLAGLRLHLELLAKvHGMGVDPLIQR--------LDQMTTSISQLLQLARvgqsFSAGS 208
Cdd:NF040691 264 leelsrlQQRFVSDVSHELRTPLTTIRMAADVIHD-SRDDFDPATARsaellhteLDRFESLLSDLLEISR----FDAGA 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 209 YQ---QVLLLDDVVKPLQDELEAMLAQRQQRLLLTDIENEAVVSGDATLIGVILRNLVENAHRYSpEGSTIRVSVKAGLM 285
Cdd:NF040691 339 AEldvEPVDLRPLVRRVVDALRQLAERAGVELRVDAPGTPVVAEVDPRRVERVLRNLVVNAIEHG-EGKPVVVTVAQDDT 417
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 286 PV-MAVEDEGPGIDEAKSGELSKAFVRMD-SR---YGGIGLGLSIVTRIAQLHDAQFFLHNRqPGPGVRAWVLFPQRGGQ 360
Cdd:NF040691 418 AVaVTVRDHGVGLKPGEVALVFDRFWRADpARartTGGTGLGLAIALEDARLHGGWLEAWGR-PGQGSQFRLTLPRVAGD 496
|
....
gi 839658588 361 NVST 364
Cdd:NF040691 497 RLTT 500
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
74-355 |
4.53e-16 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 79.29 E-value: 4.53e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 74 SLLIVGLALYISMLAV----RKITRPLSRLQSELENRTPDNLTPIVLSESVPEVTAVTTALNQLVSRLNLTLDRERLFTA 149
Cdd:PRK10549 166 SWLIVALSTLLAALATfllaRGLLAPVKRLVEGTHKLAAGDFTTRVTPTSRDELGRLAQDFNQLASTLEKNEQMRRDFMA 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 150 DVAHELRTPLAGLRLHLELLAKvhgmGV---DP-----LIQRLDQMTTSISQLLQLarvgqSFS---AGSYQQVLLldDV 218
Cdd:PRK10549 246 DISHELRTPLAVLRGELEAIQD----GVrkfTPesvasLQAEVGTLTKLVDDLHQL-----SLSdegALAYRKTPV--DL 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 219 VKPLQDELEAM---LAQRQQRlLLTDIENEAVVSGDATLIGVILRNLVENAHRYSPEGSTIRVS-VKAGLMPVMAVEDEG 294
Cdd:PRK10549 315 VPLLEVAGGAFrerFASRGLT-LQLSLPDSATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISaEQRDKTLRLTFADSA 393
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 839658588 295 PGIDEAKSGELSKAFVRMD-SR---YGGIGLGLSIVTRIAQLHDAQFFLhNRQPGPGVRAWVLFP 355
Cdd:PRK10549 394 PGVSDEQLQKLFERFYRTEgSRnraSGGSGLGLAICLNIVEAHNGRIIA-AHSPFGGVSITVELP 457
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
69-355 |
6.35e-16 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 79.02 E-value: 6.35e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 69 SLLVPSLLIVGLALYISMLAVRkitrpLSRLQSELENRTPDN---LTPIVLSESVPEVTAVTTALNQLVSRLNLTLDRER 145
Cdd:TIGR03785 412 ILAIMSIGTLALFGFASWISWR-----IRRLSDDAEAAIDSQgriSGAIPASRSRDEIGDLSRSFAQMVARLRQYTHYLE 486
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 146 LFTADVAHELRTPLAGLRLHLELLAkvhgMGVDPL------------IQRLDQMTTSISqllQLARVGQSFSAGSYQQVl 213
Cdd:TIGR03785 487 NMSSRLSHELRTPVAVVRSSLENLE----LQALEQekqkyleraregTERLSMILNNMS---EATRLEQAIQSAEVEDF- 558
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 214 llddvvkPLQDEL-EAMLAQRQ----QRLLLTDIENEAVVSGDATLIGVILRNLVENAHRYSPEGSTIRVSVKA-GLMPV 287
Cdd:TIGR03785 559 -------DLSEVLsGCMQGYQMtyppQRFELNIPETPLVMRGSPELIAQMLDKLVDNAREFSPEDGLIEVGLSQnKSHAL 631
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 839658588 288 MAVEDEGPGIDEAKSGELSKAFVRM----DSRYGGIGLGLSIVTRIAQLHDAQFFLHNRQPGPGVRAWVLFP 355
Cdd:TIGR03785 632 LTVSNEGPPLPEDMGEQLFDSMVSVrdqgAQDQPHLGLGLYIVRLIADFHQGRIQAENRQQNDGVVFRISLP 703
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
12-355 |
7.39e-16 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 77.92 E-value: 7.39e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 12 RHRLLLTIGAILVVCQLISVFWLWHESKEQIQLLVASAIEGHNNQKHVEHEVREAVASLLVPSLLIVGLALYISMLAVRK 91
Cdd:COG4191 1 ALRLLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 92 ITRPLSRLQSELENRTPDNLTPIVLSESVPEVTAVTTALNQLVSRLNLTLDR----ERL-----FTADVAHELRTPLAGL 162
Cdd:COG4191 81 LLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQlvqsEKLaalgeLAAGIAHEINNPLAAI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 163 RLHLELLAKVHGMGVDP--LIQRLDQMTTS-------ISQLLQLARVGQSFsagsyQQVLLLDDVVKPLQDELEAMLAQR 233
Cdd:COG4191 161 LGNAELLRRRLEDEPDPeeLREALERILEGaeraaeiVRSLRAFSRRDEEE-----REPVDLNELIDEALELLRPRLKAR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 234 QQRLLLTDIENEAVVSGDATLIGVILRNLVENAhRY---SPEGSTIRVSVKA-GLMPVMAVEDEGPGIDEAksgELSKAF 309
Cdd:COG4191 236 GIEVELDLPPDLPPVLGDPGQLEQVLLNLLINA-IDameEGEGGRITISTRReGDYVVISVRDNGPGIPPE---VLERIF 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 839658588 310 vrmD------SRYGGIGLGLSIVTRIAQLHDAQFFLHNRqPGPGVRAWVLFP 355
Cdd:COG4191 312 ---EpffttkPVGKGTGLGLSISYGIVEKHGGRIEVESE-PGGGTTFTITLP 359
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
258-355 |
1.82e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 68.63 E-value: 1.82e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 258 ILRNLVENAHRYSpeGSTIRVSVK-AGLMPVMAVEDEGPGIDEAKSGELSKAFVRMDSRYG--GIGLGLSIVTRIAQLHD 334
Cdd:cd16950 4 VLSNLVDNALRYG--GGWVEVSSDgEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGtsGTGLGLAIVQRISDAHG 81
|
90 100
....*....|....*....|.
gi 839658588 335 AQFFLHNRQPGpGVRAWVLFP 355
Cdd:cd16950 82 GSLTLANRAGG-GLCARIELP 101
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
80-345 |
3.03e-14 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 73.11 E-value: 3.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 80 LALYISMLAVRKITRPLSRL--------QSELENRTPDNltpivlSESVPEVTAVTTALNQLVSRLNLTLDRERLFTADV 151
Cdd:NF012226 72 ISLIIGMKLAQRFIVPINFLadaakkisQGDLSARAEDS------QIHSAEISELMHNFNDMAQKLESSVKNAQVWNAAI 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 152 AHELRTPLAGLR----------------LHLELLAKVHGMGVdpLIQRLDQMTTSISQLLQLarvgqsfsagSYQQVLLL 215
Cdd:NF012226 146 AHELRTPITILQgrlqgildgvfepdpaLFKSLLNQVEGLSH--LVEDLRTLSLVENQQLRL----------NYESVDLK 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 216 DDVVKPLQdELEAMLAQRQQRLLLtDIENEAvVSGDATLIGVILRNLVENAHRYSPEGS-TIRVSVKAGLMpVMAVEDEG 294
Cdd:NF012226 214 DSIEKVLK-MFEDRLEQAQLTIVL-NLTATP-VFCDRRRIEQVLIALIDNAIRYANAGKlKISSSVIQDDW-ILQIEDEG 289
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 839658588 295 PGIDEAKSGELSKAFVRM-DSR---YGGIGLGLSIVTRIAQLHDAQFFLHNRQPG 345
Cdd:NF012226 290 PGIAEEYQQDLFNPFFRLeQSRnkeFGGTGLGLAVVHAIVIAHKGSIEYSNSQGN 344
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
147-331 |
6.91e-14 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 73.02 E-value: 6.91e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 147 FTADVAHELRTPLAGLRLHLELLAKvhgmgvDPLIQR----LDQMTTSISQLLQLARVGQSFSA---GSyQQVLLLDDVV 219
Cdd:PRK11466 447 FLAAMSHEIRTPLYGILGTAQLLAD------NPALNAqrddLRAITDSGESLLTILNDILDYSAieaGG-KNVSVSDEPF 519
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 220 KP---LQDELEAMLAQRQQRL--LLTDIENE--AVVSGDATLIGVILRNLVENAHRYSPEGSTIRVSVKAGLMPVMAVED 292
Cdd:PRK11466 520 EPrplLESTLQLMSGRVKGRPirLATDIADDlpTALMGDPRRIRQVITNLLSNALRFTDEGSIVLRSRTDGEQWLVEVED 599
|
170 180 190
....*....|....*....|....*....|....*....
gi 839658588 293 EGPGIDEAKSGELSKAFVRMDSRYGGIGLGLSIVTRIAQ 331
Cdd:PRK11466 600 SGCGIDPAKLAEIFQPFVQVSGKRGGTGLGLTISSRLAQ 638
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
258-355 |
8.27e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 67.13 E-value: 8.27e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 258 ILRNLVENAHRYSPEGS-TIRVSV----KAGLMPVMAVEDEGPGIDEAKSGELSKAFVRMDS----RYGGIGLGLSIVTR 328
Cdd:cd16922 4 ILLNLLGNAIKFTEEGEvTLRVSLeeeeEDGVQLRFSVEDTGIGIPEEQQARLFEPFSQADSsttrKYGGTGLGLAISKK 83
|
90 100
....*....|....*....|....*..
gi 839658588 329 IAQLHDAQFFLHNrQPGPGVRAWVLFP 355
Cdd:cd16922 84 LVELMGGDISVES-EPGQGSTFTFTLP 109
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
139-356 |
1.05e-13 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 72.38 E-value: 1.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 139 LTLDRERL---FTADVAHELRTPLAGLR-----LHLELLAK--VHGMGVDPLIQRLDQMTTSISQLLQLARVgQSFSAGS 208
Cdd:PRK10490 656 LASEREQLrnaLLAALSHDLRTPLTVLFgqaeiLTLDLASEgsPHARQASEIRQQVLNTTRLVNNLLDMARI-QSGGFNL 734
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 209 YQQVLLLDDVVKPLQDELEAMLAQRQQRLLLTDieNEAVVSGDATLIGVILRNLVENAHRYSPEGST--IRVSVKAGLMP 286
Cdd:PRK10490 735 RKEWLTLEEVVGSALQMLEPGLSGHPINLSLPE--PLTLIHVDGPLFERVLINLLENAVKYAGAQAEigIDAHVEGERLQ 812
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 839658588 287 VmAVEDEGPGIDEAKSGELSKAFVRMD--SRYGGIGLGLSIVTRIAQLHDAQFFLHNRQPGpGVRAWVLFPQ 356
Cdd:PRK10490 813 L-DVWDNGPGIPPGQEQLIFDKFARGNkeSAIPGVGLGLAICRAIVEVHGGTIWAENRPEG-GACFRVTLPL 882
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
261-357 |
1.01e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 63.76 E-value: 1.01e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 261 NLVENAHRYSPEGSTIRV---SVKAGLMpvMAVEDEGPGIDEAKSGELSKAFVRMD----SRYGGIGLGLSIVTRIAQLH 333
Cdd:cd16952 7 NLVSNAVKYTPPSDTITVrwsQEESGAR--LSVEDTGPGIPPEHIPRLTERFYRVDiercRNTGGTGLGLAIVKHVMSRH 84
|
90 100
....*....|....*....|....
gi 839658588 334 DAQFFLHNrQPGPGVRAWVLFPQR 357
Cdd:cd16952 85 DARLLIAS-ELGKGSRFTCLFPSS 107
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
151-355 |
1.10e-12 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 68.33 E-value: 1.10e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 151 VAHELRTPLAGLRLHLELLAkvHGMGVDPLIQRLDQMTTS-------ISQLLQLARvgqsFSAGSYQQV---LLLDDVVK 220
Cdd:COG3852 142 LAHEIRNPLTGIRGAAQLLE--RELPDDELREYTQLIIEEadrlnnlVDRLLSFSR----PRPPEREPVnlhEVLERVLE 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 221 PLQDELEAMLaqRQQRLLLTDIENeavVSGDATLIGVILRNLVENAHRYSPEGSTIRVSVK-----------AGLMPVMA 289
Cdd:COG3852 216 LLRAEAPKNI--RIVRDYDPSLPE---VLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRverqvtlgglrPRLYVRIE 290
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 839658588 290 VEDEGPGIDEAKSGELSKAFVRmdSRYGGIGLGLSIVTRIAQLHDAQFFLHNRqPGPGVRAWVLFP 355
Cdd:COG3852 291 VIDNGPGIPEEILDRIFEPFFT--TKEKGTGLGLAIVQKIVEQHGGTIEVESE-PGKGTTFRIYLP 353
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
144-336 |
1.67e-12 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 68.46 E-value: 1.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 144 ERL-----FTADVAHELRTPLAGLRLHLELLAKV----HGMGVDPLIQRLDQMTTSISQLLQLARVgqsfSAGSYQQVLL 214
Cdd:COG5809 265 EKLsvvgeLAAGIAHEIRNPLTSLKGFIQLLKDTideeQKTYLDIMLSELDRIESIISEFLVLAKP----QAIKYEPKDL 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 215 LD---DVVKPLQDelEAMLAQRQQRLLLTDieNEAVVSGDATLIGVILRNLVENAHRYSPEGSTIRVSVKAglMP----V 287
Cdd:COG5809 341 NTlieEVIPLLQP--QALLKNVQIELELED--DIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKA--EDddkvV 414
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 839658588 288 MAVEDEGPGIDEAKSGELSKAFvrMDSRYGGIGLGLSIVTRIAQLHDAQ 336
Cdd:COG5809 415 ISVTDEGCGIPEERLKKLGEPF--YTTKEKGTGLGLMVSYKIIEEHGGK 461
|
|
| HK_WalK |
NF033092 |
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in ... |
141-333 |
2.29e-12 |
|
cell wall metabolism sensor histidine kinase WalK; This model describes WalK as found in Staphylococcus aureus (sp|Q2G2U4.1|WALK_STAA8). A shorter version, as found in Streptococcus pneumoniae, called WalK(Spn) or VicK, is not included. WalK is part of a two-component system and works with partner protein WalR.
Pssm-ID: 467964 [Multi-domain] Cd Length: 594 Bit Score: 68.24 E-value: 2.29e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 141 LDRER-LFTADVAHELRTPLAGLRLHLELLAKvhGMGVDPLI--QRL-------DQMTTSISQLLQLARvgqsFSAGSYQ 210
Cdd:NF033092 368 IEQERrEFVANVSHELRTPLTTMRSYLEALAD--GAWKDPELapRFLgvtqnetERMIRLVNDLLQLSR----MDSKDYK 441
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 211 QVLLLDDVVKPLQ---DELEAMLAQRQQRLLLtDIENEAV-VSGDATLIGVILRNLVENAHRYSPEGSTIRVSVKA-GLM 285
Cdd:NF033092 442 LNKEWVNFNEFFNyiiDRFEMILKNKNITFKR-EFPKRDLwVEIDTDKITQVLDNIISNAIKYSPEGGTITFRLLEtHNR 520
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 839658588 286 PVMAVEDEGPGIDEAKSGELSKAFVRMD---SR-YGGIGLGLSIVTRIAQLH 333
Cdd:NF033092 521 IIISISDQGLGIPKKDLDKIFDRFYRVDkarSRkMGGTGLGLAIAKEVVEAH 572
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
259-345 |
4.76e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 61.96 E-value: 4.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 259 LRNLVENAHRYSPEGSTIRVSVKAGLMpVMAVEDEGPGIDEAKSGELSKAFVRMDSRY----GGIGLGLSIVTRIAQLHD 334
Cdd:cd16949 5 LENVLRNALRYSPSKILLDISQDGDQW-TITITDDGPGVPEDQLEQIFLPFYRVDSARdresGGTGLGLAIAERAIEQHG 83
|
90
....*....|.
gi 839658588 335 AQFFLHNRQPG 345
Cdd:cd16949 84 GKIKASNRKPG 94
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
116-333 |
1.21e-11 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 65.36 E-value: 1.21e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 116 LSESVPEVTAVTTALNQL---VSRL---NLTLdRERLFTAD-----VAHELRTPLAGLRLHLELLA----KVHGMGVDPL 180
Cdd:PRK09303 113 LQPSEIDSGRYSQELLQLsdeLFVLrqeNETL-LEQLKFKDrvlamLAHDLRTPLTAASLALETLElgqiDEDTELKPAL 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 181 IQRLDQMTTS--------ISQLLQLARvGQSFSAGSYQQVLLLDDVVKPLQDELEAMLAQRQQRLLlTDIENE-AVVSGD 251
Cdd:PRK09303 192 IEQLQDQARRqleeierlITDLLEVGR-TRWEALRFNPQKLDLGSLCQEVILELEKRWLAKSLEIQ-TDIPSDlPSVYAD 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 252 ATLIGVILRNLVENAHRYSPEGSTIRVS--------VKaglmpvMAVEDEGPGIDEAKSGELSKAFVRM--DSRYGGIGL 321
Cdd:PRK09303 270 QERIRQVLLNLLDNAIKYTPEGGTITLSmlhrttqkVQ------VSICDTGPGIPEEEQERIFEDRVRLprDEGTEGYGI 343
|
250
....*....|..
gi 839658588 322 GLSIVTRIAQLH 333
Cdd:PRK09303 344 GLSVCRRIVRVH 355
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
259-333 |
1.25e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 60.52 E-value: 1.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 259 LRNLVENAHRYSpeGSTIRVSVKA-GLMPVMAVEDEGPGIDEAKSGELSKAFVRMDS----RYGGIGLGLSIVTRIAQLH 333
Cdd:cd16939 5 LDNLLRNALRYA--HRTVRIALLVsGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPsrdrATGGFGLGLAIVHRVALWH 82
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
148-335 |
2.24e-11 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 64.75 E-value: 2.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 148 TADVAHELRTPLAGLRLHLELLakvhGMGV-------DPLIQRLDQMTTSISQLLQLARVGQ-SFSAGSYQQvlLLDDVV 219
Cdd:COG5805 291 AAGIAHEIRNPLTSIKGFLQLL----QPGIedkeeyfDIMLSELDRIESIISEFLALAKPQAvNKEKENINE--LIQDVV 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 220 KPLqdELEAMLAQRQQRLLLTDiENeAVVSGDATLIGVILRNLVENAHRYSPEGSTIRVSVKAGLMPVM-AVEDEGPGID 298
Cdd:COG5805 365 TLL--ETEAILHNIQIRLELLD-ED-PFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIiRVIDEGIGIP 440
|
170 180 190
....*....|....*....|....*....|....*..
gi 839658588 299 EAKSGELSKAFVRMDSRygGIGLGLSIVTRIAQLHDA 335
Cdd:COG5805 441 EERLKKLGEPFFTTKEK--GTGLGLMVSYKIIENHNG 475
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
251-355 |
3.63e-11 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 59.43 E-value: 3.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 251 DATLIGVILRNLVENAHRYSPEGSTIRVSVKAGLMP--VMAVEDEGPGIDEAKSGELSKAFVRMDS----RYGGIGLGLS 324
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRLNrfLLTVSDSGPGIPPNLREEIFERFRQGDGsstrAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|.
gi 839658588 325 IVTRIAQLHDAQFFLHNrQPGPGVRAWVLFP 355
Cdd:cd16925 81 IVKEFVELHGGTVTVSD-APGGGALFQVELP 110
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
128-355 |
5.17e-10 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 60.75 E-value: 5.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 128 TALNQLVSRLNLTldrERL-----FTADVAHELRTPLAGLRLHLELLAK-----VHGMGVDPLIQRLDQMTTSISQLLQL 197
Cdd:PRK11360 372 TERKRLQRRVARQ---ERLaalgeLVAGVAHEIRNPLTAIRGYVQIWRQqtsdpPSQEYLSVVLREVDRLNKVIDQLLEF 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 198 ARVGQSfsagSYQQVLLLDDVVKPLQDELEAMLAQRQQRLLLTDIENEAVVSgDATLIGVILRNLVENAHRYSPEGSTIR 277
Cdd:PRK11360 449 SRPRES----QWQPVSLNALVEEVLQLFQTAGVQARVDFETELDNELPPIWA-DPELLKQVLLNILINAVQAISARGKIR 523
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 278 VSV---KAGLMPVmAVEDEGPGIDEAKSGELSKAFvrMDSRYGGIGLGLSIVTRIAQLHDAQFFLHNRqPGPGVRAWVLF 354
Cdd:PRK11360 524 IRTwqySDGQVAV-SIEDNGCGIDPELLKKIFDPF--FTTKAKGTGLGLALSQRIINAHGGDIEVESE-PGVGTTFTLYL 599
|
.
gi 839658588 355 P 355
Cdd:PRK11360 600 P 600
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
251-351 |
5.69e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 55.93 E-value: 5.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 251 DATLIGVILRNLVENAHRYSPEGSTIRVSVKAGLMPV-MAVEDEGPGI-DEAKSGELSKAF--VRMDSRYGGIGLGLSIV 326
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIeLLVFDEGSGIpDYALNRVFERFYslPRPHSGQKSTGLGLAFV 80
|
90 100
....*....|....*....|....*
gi 839658588 327 TRIAQLHDAQFFLHNRQPGPGVRAW 351
Cdd:cd16945 81 QEVAQLHGGRITLRNRPDGVLAFLT 105
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
221-354 |
1.44e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 55.72 E-value: 1.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 221 PLQDELEAMLA---QRQQRLLLTDIENEAVVSGDATLIGVILRNLVENAHRYSPEgstiRVSVKAGLMP---VMAVEDEG 294
Cdd:cd16954 1 PLLDSLCSALNkvyQRKGVSISLDISPELRFPGERNDLMELLGNLLDNACKWCLE----FVEVTARQTDgglHLIVDDDG 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 295 PGIDEAKSGELSKAFVRMDSRYGGIGLGLSIVTRIAQLHDAQFFLhNRQPGPGVRAWVLF 354
Cdd:cd16954 77 PGVPESQRSKIFQRGQRLDEQRPGQGLGLAIAKEIVEQYGGELSL-SDSPLGGARFEVVF 135
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
149-349 |
1.49e-09 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 59.66 E-value: 1.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 149 ADVAHELRTPLAGLRLHLELL------AKVHGMGvDPLIQRLDQMTTSISQLLQLARV--GQ-SFSAGSYQQVLLLDDVV 219
Cdd:PRK15347 403 TTISHEIRTPLNGVLGALELLqntpltAEQMDLA-DTARQCTLSLLAIINNLLDFSRIesGQmTLSLEETALLPLLDQAM 481
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 220 KPLQDE-LEAMLAQRQqrLLLTDIENEAVVsgDATLIGVILRNLVENAHRYSPEGStIRVSVKA-GLMPVMAVEDEGPGI 297
Cdd:PRK15347 482 LTIQGPaQSKSLTLRT--FVGAHVPLYLHL--DSLRLRQILVNLLGNAVKFTETGG-IRLRVKRhEQQLCFTVEDTGCGI 556
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 839658588 298 DEAKSGELSKAFVRMDSRYGGIGLGLSIVTRIAQLHDAQFFLhNRQPGPGVR 349
Cdd:PRK15347 557 DIQQQQQIFTPFYQADTHSQGTGLGLTIASSLAKMMGGELTL-FSTPGVGSC 607
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
258-355 |
1.63e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 54.78 E-value: 1.63e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 258 ILRNLVENAHRYSPEGSTIRVSvkAGLMP---VMAVEDEGPGIDEAKSGELSKAFVRMDSR----YGGIGLGLSIVTRIA 330
Cdd:cd16946 8 LFVNLLENSLRYTDTGGKLRIR--AAQTPqevRLDVEDSAPGVSDDQLARLFERFYRVESSrnraSGGSGLGLAICHNIA 85
|
90 100
....*....|....*....|....*
gi 839658588 331 QLHDAQfFLHNRQPGPGVRAWVLFP 355
Cdd:cd16946 86 LAHGGT-ISAEHSPLGGLRLVLTLP 109
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
255-355 |
2.19e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 54.26 E-value: 2.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 255 IGVILRNLVENAHRYSPEGSTIRVSVKA---GLMPVMAVEDEGPGIDEAKSGELSKAFVRMDSR--YGGIGLGLSIVTRI 329
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAedvGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSReeYEGTGVGLAIVRKI 80
|
90 100
....*....|....*....|....*.
gi 839658588 330 AQLHDAQFFLHNrQPGPGVRAWVLFP 355
Cdd:cd16921 81 IERHGGRIWLES-EPGEGTTFYFTLP 105
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
56-359 |
3.23e-09 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 58.11 E-value: 3.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 56 QKHVEHEVREAVASLLVPSLLIVGLALYISMLAVRKITRPLSRLQSELENRTPDNLTPIVLSESVpEVTAVTTALNQLVS 135
Cdd:COG2972 145 KSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDLVRLEVSGND-EIGILARSFNEMVE 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 136 RLNLTLDRERlftadvAHELRtplaglRLHLEL---------------------LAKVHGMgvdpliQRLDQMTTSISQL 194
Cdd:COG2972 224 RIKELIEEVY------ELELE------KKEAELkalqaqinphflfntlnsirwLAELEDP------EEAEEMLEALSKL 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 195 LQlarvgQSFSAGsyQQVLLLDDVVKPLQDELEAMLAQRQQRLLLT-DIENEAvvsGDATLIGVILRNLVENA--H--RY 269
Cdd:COG2972 286 LR-----YSLSKG--DELVTLEEELELIKSYLEIQKLRFGDRLEVEiEIDEEL---LDLLIPKLILQPLVENAieHgiEP 355
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 270 SPEGSTIRVSV-KAGLMPVMAVEDEGPGIDEAKsgeLSKAFVRMDSRYGGIGLGLSIVTRIAQLH---DAQFFLHNRqPG 345
Cdd:COG2972 356 KEGGGTIRISIrKEGDRLVITVEDNGVGMPEEK---LEKLLEELSSKGEGRGIGLRNVRERLKLYygeEYGLEIESE-PG 431
|
330
....*....|....
gi 839658588 346 PGVRAWVLFPQRGG 359
Cdd:COG2972 432 EGTTVTIRIPLEEE 445
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
258-340 |
1.27e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 52.00 E-value: 1.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 258 ILRNLVENAHRYSPEGSTIRVSV-----KAGLMpvmaVEDEGPGIDEAKSGELSKAFVRMD-SRY-GGIGLGLSIVTRIA 330
Cdd:cd16923 4 VFSNLLSNAIKYSPENTRIYITSfltddVVNIM----FKNPSSHPLDFKLEKLFERFYRGDnSRNtEGAGLGLSIAKAII 79
|
90
....*....|
gi 839658588 331 QLHDAQFFLH 340
Cdd:cd16923 80 ELHGGSASAE 89
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
141-199 |
2.15e-08 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 50.29 E-value: 2.15e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 839658588 141 LDRERLFTADVAHELRTPLAGLRLHLELLA------KVHGMGVDPLIQRLDQMTTSISQLLQLAR 199
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEeellddEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
76-354 |
2.17e-08 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 55.41 E-value: 2.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 76 LIVGLALYISML--AVRKITRP---LSRLQSELENRTPDNLTPivlsesvpevtAVTTALNQLVSRLNLTLDRER-LFT- 148
Cdd:PRK10815 197 LLANLLLVIPLLwlAAWWSLRPieaLAKQVRELEEGEREQLDP-----------NPPRELTSLVRNLNRLLKNEReRYTk 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 149 -----ADVAHELRTPLAGLRLHLELLakvhgmgvdpliqRLDQmTTSISQ-----LLQLARVGQSFsaGSY--------Q 210
Cdd:PRK10815 266 yrttlTDLTHSLKTPLAVLQSTLRSL-------------RSGK-QMSVEQaepimLEQISRISQQI--GYYlhrasmrsE 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 211 QVLLLDDV--VKPLQDELEAMLAQRQQR---LLLTDIENEAVVSGDATLIGVILRNLVENAHRYSPEgsTIRVSVKAGLM 285
Cdd:PRK10815 330 HNLLSRELhsVAPLLDNLTSALNKVYQRkgvNITLDISPEITFVGEKNDFMEVMGNVLDNACKYCLE--FVEISARQTDE 407
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 286 PVM-AVEDEGPGIDEAKSGELSKAFVRMDSRYGGIGLGLSIVTRIAQLHDAQFFLHNRQPGpGVRAWVLF 354
Cdd:PRK10815 408 HLHiVVEDDGPGIPESKRELIFDRGQRADTLRPGQGLGLSVAREITEQYEGKISAGDSPLG-GARMEVIF 476
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
255-344 |
2.24e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 51.80 E-value: 2.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 255 IGVILRNLVENAHRYSPEgSTIRVSVKA---GLMPVMAVEDEGPGIDEAKsgeLSKAFVRMDSR------YG-GIGLGLS 324
Cdd:cd16953 1 LGQVLRNLIGNAISFSPP-DTGRITVSAmptGKMVTISVEDEGPGIPQEK---LESIFDRFYTErpaneaFGqHSGLGLS 76
|
90 100
....*....|....*....|
gi 839658588 325 IVTRIAQLHDAQFFLHNRQP 344
Cdd:cd16953 77 ISRQIIEAHGGISVAENHNQ 96
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
145-202 |
3.23e-08 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 49.90 E-value: 3.23e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 839658588 145 RLFTADVAHELRTPLAGLRLHLELLAKVHGMG-----VDPLIQRLDQMTTSISQLLQLARVGQ 202
Cdd:pfam00512 3 SEFLANLSHELRTPLTAIRGYLELLRDEKLDEeqreyLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
145-202 |
6.31e-08 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 49.10 E-value: 6.31e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 839658588 145 RLFTADVAHELRTPLAGLRLHLELLAKVHGMG-----VDPLIQRLDQMTTSISQLLQLARVGQ 202
Cdd:smart00388 3 REFLANLSHELRTPLTAIRGYLELLLDTELSEeqreyLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
251-355 |
8.81e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 49.84 E-value: 8.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 251 DATLIGVILRNLVENAH-----RYSPEGS-TIRVSVKAGLMPVMAVEDEGPGIDEAKSGELSKAFVrmDSRYGGIGLGLS 324
Cdd:cd16944 1 DTTQISQVLTNILKNAAeaiegRPSDVGEvRIRVEADQDGRIVLIVCDNGKGFPREMRHRATEPYV--TTRPKGTGLGLA 78
|
90 100 110
....*....|....*....|....*....|.
gi 839658588 325 IVTRIAQLHDAQFFLHNRqPGPGVRAWVLFP 355
Cdd:cd16944 79 IVKKIMEEHGGRISLSNR-EAGGACIRIILP 108
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
241-342 |
4.43e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 48.28 E-value: 4.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 241 DIENEAVVS-GDATLIGVILRNLVENAHRYSPEGSTIRVSVKAGLMPV-MAVEDEGPGIDEAksgELSKAFVRM------ 312
Cdd:cd16947 6 NIPDRPIYAnANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVyIDIWDKGKGISET---EKDHVFERLytleds 82
|
90 100 110
....*....|....*....|....*....|.
gi 839658588 313 -DSRYGGIGLGLSIVTRIAQLHDAQFFLHNR 342
Cdd:cd16947 83 rNSAKQGNGLGLTITKRLAESMGGSIYVNSK 113
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
147-331 |
6.17e-07 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 51.39 E-value: 6.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 147 FTADVAHELRTPLAGL----RLHLEllakvhgmgvDPL--IQRlDQMTT---SISQLLQLARVGQSFS---AGSyqqvLL 214
Cdd:PRK11107 296 FLANMSHELRTPLNGVigftRQTLK----------TPLtpTQR-DYLQTierSANNLLAIINDILDFSkleAGK----LV 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 215 LDDVVKPLQDELE---AMLAQ--RQQRLLLT-DIENE--AVVSGDATLIGVILRNLVENAHRYSPEGST-IRVSVKAG-- 283
Cdd:PRK11107 361 LENIPFSLRETLDevvTLLAHsaHEKGLELTlNIDPDvpDNVIGDPLRLQQIITNLVGNAIKFTESGNIdILVELRALsn 440
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 839658588 284 ---LMPVMaVEDEGPGIDEAKSGELSKAFVRMDS----RYGGIGLGLSIVTRIAQ 331
Cdd:PRK11107 441 tkvQLEVQ-IRDTGIGISERQQSQLFQAFRQADAsisrRHGGTGLGLVITQKLVN 494
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
251-345 |
1.41e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 46.30 E-value: 1.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 251 DATLIGVILRNLVENAHRYSPEGSTIRVSVKAGLMPV-MAVEDEGPGIDEAKSGELSKAFVRMD-SRYGG--IGLGLSIV 326
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLyFEIWDNGHGFSEQDLKKALELFYRDDtSRRSGghYGMGLYIA 80
|
90
....*....|....*....
gi 839658588 327 TRIAQLHDAQFFLHNRQPG 345
Cdd:cd16975 81 KNLVEKHGGSLIIENSQKG 99
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
258-359 |
2.76e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 45.47 E-value: 2.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 258 ILRNLVENAHRYSPEGS------TIRVSVKAGLMPVMAVEDEGPGIDEAKSGELSKAFVrmDSRYGGIGLGLSIVTRIAQ 331
Cdd:cd16920 4 VLINLVRNGIEAMSEGGcerrelTIRTSPADDRAVTISVKDTGPGIAEEVAGQLFDPFY--TTKSEGLGMGLSICRSIIE 81
|
90 100
....*....|....*....|....*...
gi 839658588 332 LHdaqfflhnrqpgpGVRAWVLFPQRGG 359
Cdd:cd16920 82 AH-------------GGRLSVESPAGGG 96
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
151-339 |
4.81e-06 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 48.53 E-value: 4.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 151 VAHELRTPLAGLRLHLELLAKVHGMG-----------VDPLIQRLDQMTTSisqLLQLARVGQSfsagSYQQVLLLDDVV 219
Cdd:COG4192 440 LAHELNQPLNAMSMYLFSAKKALEQEnyaqlptsldkIEGLIERMDKIIKS---LRQFSRKSDT----PLQPVDLRQVIE 512
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 220 KPLqdELEAMLAQRQQRLLltDIENEAVVSGDATLIGVILRNLVENAHRYSPEGSTIRVSV-KAGLMPVMAVEDEGPGID 298
Cdd:COG4192 513 QAW--ELVESRAKPQQITL--HIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLlSNAENLRVAISDNGNGWP 588
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 839658588 299 EAKSgeLSKAFVrmDSRYGGIGLGLSIVTRIAQLHDAQFFL 339
Cdd:COG4192 589 LVDK--LFTPFT--TTKEVGLGLGLSICRSIMQQFGGDLYL 625
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
246-363 |
3.71e-05 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 45.82 E-value: 3.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 246 AVVSGDATLIGVILRNLVENAHRYSPEGSTIRVSVKA-----------GLMP-----VMAVEDEGPGIDEAKSGELSKAF 309
Cdd:PRK13837 552 AVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRaklrapkvlshGVLPpgryvLLRVSDTGAGIDEAVLPHIFEPF 631
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 839658588 310 vrMDSRYGGIGLGLSIVTRIAQLHDAQFFLHNRqPGPGVRAWVLFPQRGGQNVS 363
Cdd:PRK13837 632 --FTTRAGGTGLGLATVHGIVSAHAGYIDVQST-VGRGTRFDVYLPPSSKVPVA 682
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
137-363 |
1.18e-04 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 44.34 E-value: 1.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 137 LNLTLDRERlFTADVAHELRTPLAGLRLHLELLAKvHGMGVDPLIQRLDQMTTSISQLLQLarVGQ-----SFSAGSYQ- 210
Cdd:PRK09959 706 INATVAKSQ-FLATMSHEIRTPISSIMGFLELLSG-SGLSKEQRVEAISLAYATGQSLLGL--IGEildvdKIESGNYQl 781
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 211 --QVLLLDDVVKPLQDELEAMLAQRQQRLLLTD-IENEAVVSGDATLIGVILRNLVENAHRYSPEGStirVSVKAGLMPV 287
Cdd:PRK09959 782 qpQWVDIPTLVQNTCHSFGAIAASKSIALSCSStFPDHYLVKIDPQAFKQVLSNLLSNALKFTTEGA---VKITTSLGHI 858
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 288 --------MAVEDEGPGIDEAKSGELSKAFVRMDS--RYGGIGLGLSIVTRIAQLHDAQFFLHNrQPGPGVRAWVLFPQR 357
Cdd:PRK09959 859 ddnhavikMTIMDSGSGLSQEEQQQLFKRYSQTSAgrQQTGSGLGLMICKELIKNMQGDLSLES-HPGIGTTFTITIPVE 937
|
....*.
gi 839658588 358 GGQNVS 363
Cdd:PRK09959 938 ISQQVA 943
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
248-332 |
1.69e-04 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 43.39 E-value: 1.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 248 VSGDATLIGVILRNLVENAHRYSPEGS-TIRVSVKAGLMPVMAVEDEGPGIDEAksgELSKAFVrM-----DSRYG---- 317
Cdd:PRK11091 392 VITDGTRLRQILWNLISNAVKFTQQGGvTVRVRYEEGDMLTFEVEDSGIGIPED---ELDKIFA-MyyqvkDSHGGkpat 467
|
90
....*....|....*
gi 839658588 318 GIGLGLSIVTRIAQL 332
Cdd:PRK11091 468 GTGIGLAVSKRLAQA 482
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
258-349 |
6.63e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 38.59 E-value: 6.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 258 ILRNLVENAHR--YSPEGSTIRVSVK-AGLMPVMAVEDEGPGIDEAKSGELSKAFVRMDSRYGGIGLGLSIVTRIAQLHD 334
Cdd:cd16976 4 VLMNLLQNALDamGKVENPRIRIAARrLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYGIVEEHG 83
|
90
....*....|....*
gi 839658588 335 AQFFLHNrQPGPGVR 349
Cdd:cd16976 84 GRLSVAN-EEGAGAR 97
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
145-325 |
9.39e-04 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 40.83 E-value: 9.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 145 RLFTADVAHELRTPLAGLRLHLELLAKvhgMGVDP------------------LIQRL-------DQMTTSISQLLQlaR 199
Cdd:PRK11073 131 RDLVRGLAHEIKNPLGGLRGAAQLLSK---ALPDPalteytkviieqadrlrnLVDRLlgpqrpgTHVTESIHKVAE--R 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 200 VGQSFSAGSYQQVLLLDDvVKPLQDELEAMLAQRQQRLL-LTDIENEAVVSGDATligVILRNlvENAHRYSPEGSTIRV 278
Cdd:PRK11073 206 VVQLVSLELPDNVRLIRD-YDPSLPELAHDPDQIEQVLLnIVRNALQALGPEGGT---ITLRT--RTAFQLTLHGERYRL 279
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 839658588 279 SVKaglmpvMAVEDEGPGIDEAKSGELskaFVRMDS-RYGGIGLGLSI 325
Cdd:PRK11073 280 AAR------IDIEDNGPGIPPHLQDTL---FYPMVSgREGGTGLGLSI 318
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
258-355 |
1.22e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 38.17 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 258 ILRNLVENAHRYSPEGSTIRVSVKAGLMPV-MAVEDEGPGIDEAKSGELSKAFVRMDSRYGGIGLGLSIVTRIAQLHDAQ 336
Cdd:cd16943 7 VLLNLLVNAAQAMEGRGRITIRTWAHVDQVlIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGTGLGLSLSYRIIQKHGGT 86
|
90
....*....|....*....
gi 839658588 337 FFLHNrQPGPGVRAWVLFP 355
Cdd:cd16943 87 IRVAS-VPGGGTRFTIILP 104
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
254-333 |
2.74e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 36.99 E-value: 2.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 839658588 254 LIGVILrNLVENAHRYSPEGS---TIRVSVKAG---------LMPVMAVEDEGPGIDEAKSGELSKAFVrmDSRYGGIGL 321
Cdd:cd16918 1 LIQVFL-NLVRNAAQALAGSGgeiILRTRTQRQvtlghprhrLALRVSVIDNGPGIPPDLQDTIFYPMV--SGRENGTGL 77
|
90
....*....|..
gi 839658588 322 GLSIVTRIAQLH 333
Cdd:cd16918 78 GLAIAQNIVSQH 89
|
|
| |
