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Conserved domains on  [gi|900894219|gb|KMY95764|]
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uncharacterized protein Dsimw501_GD28278 [Drosophila simulans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
pgc cd20259
polar granule component; Polar granule component (pgc) is implicated in primordial germ cell ...
 1-92 3.13e-25

polar granule component; Polar granule component (pgc) is implicated in primordial germ cell specification in Drosophila, which require transcriptional quiescence and three genes: pgc, nano (nos) and germ cell less (gcl), that act to down-regulate Pol II transcription. The microprotein pgc inhibits transcription elongation factor b (P-TEFb), which phosphorylates the C-terminal domain of the largest Pol II subunit.


:

Pssm-ID: 380770  Cd Length: 66  Bit Score: 89.68  E-value: 3.13e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 900894219   1 MFNFKFEYSFMFESSGCEGKFlgmpydgefeamwqqigdelrsrhnrFLGMPFDSGFERMWRQVREELKRDREDNKFALC 80
Cdd:cd20259    1 MCDYEHEYSFVFDDSECESDF--------------------------FSGMPFDSGFESMWRQIREELRREQEMNELAQL 54

                         90
                 ....*....|..
gi 900894219  81 FQRKLSIYVKEE 92
Cdd:cd20259   55 FQQKLTLSPKEE 66
 
Name Accession Description Interval E-value
pgc cd20259
polar granule component; Polar granule component (pgc) is implicated in primordial germ cell ...
 1-92 3.13e-25

polar granule component; Polar granule component (pgc) is implicated in primordial germ cell specification in Drosophila, which require transcriptional quiescence and three genes: pgc, nano (nos) and germ cell less (gcl), that act to down-regulate Pol II transcription. The microprotein pgc inhibits transcription elongation factor b (P-TEFb), which phosphorylates the C-terminal domain of the largest Pol II subunit.


Pssm-ID: 380770  Cd Length: 66  Bit Score: 89.68  E-value: 3.13e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 900894219   1 MFNFKFEYSFMFESSGCEGKFlgmpydgefeamwqqigdelrsrhnrFLGMPFDSGFERMWRQVREELKRDREDNKFALC 80
Cdd:cd20259    1 MCDYEHEYSFVFDDSECESDF--------------------------FSGMPFDSGFESMWRQIREELRREQEMNELAQL 54

                         90
                 ....*....|..
gi 900894219  81 FQRKLSIYVKEE 92
Cdd:cd20259   55 FQQKLTLSPKEE 66
 
Name Accession Description Interval E-value
pgc cd20259
polar granule component; Polar granule component (pgc) is implicated in primordial germ cell ...
 1-92 3.13e-25

polar granule component; Polar granule component (pgc) is implicated in primordial germ cell specification in Drosophila, which require transcriptional quiescence and three genes: pgc, nano (nos) and germ cell less (gcl), that act to down-regulate Pol II transcription. The microprotein pgc inhibits transcription elongation factor b (P-TEFb), which phosphorylates the C-terminal domain of the largest Pol II subunit.


Pssm-ID: 380770  Cd Length: 66  Bit Score: 89.68  E-value: 3.13e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 900894219   1 MFNFKFEYSFMFESSGCEGKFlgmpydgefeamwqqigdelrsrhnrFLGMPFDSGFERMWRQVREELKRDREDNKFALC 80
Cdd:cd20259    1 MCDYEHEYSFVFDDSECESDF--------------------------FSGMPFDSGFESMWRQIREELRREQEMNELAQL 54

                         90
                 ....*....|..
gi 900894219  81 FQRKLSIYVKEE 92
Cdd:cd20259   55 FQQKLTLSPKEE 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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