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Conserved domains on  [gi|912086015|gb|KNT82613|]
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DeoR faimly transcriptional regulator [Salmonella enterica subsp. enterica serovar Dublin]

Protein Classification

DeoR/GlpR family DNA-binding transcription regulator( domain architecture ID 11442564)

DeoR/GlpR family DNA-binding transcription regulator is a helix-turn-helix type transcriptional regulator that may be involved in sugar metabolism

Gene Ontology:  GO:0003700|GO:0003677
PubMed:  15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 1-233 7.17e-86

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


:

Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 255.83  E-value: 7.17e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015   1 MNPIKRRKHILDELNKFGEVTVIKLSEMLNVTSETIRRDLSLLESEGKITKIHGGAVKK-QVVQEDAFSARIEAHREEKI 79
Cdd:COG1349    1 MLAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVsSAAAEPPFAERETLNAEEKR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015  80 AIGKLAAEMVSERDTLFIDSCTTNLILAEQLPPLA-FSVITNSALIADKIKEHNlQARVYVLGGEYDYHFRANLGVSVCQ 158
Cdd:COG1349   81 AIARAAASLIEDGDTIFLDAGTTTLALARALPDRRnLTVVTNSLNIANELAERP-NIEVILLGGELRPSSGSLVGPLAEE 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 912086015 159 QINAIHADICFIGAGGISPQHGVLVKSFEEAYVAKAMIAMSKKSVILADHTKFGQDGVMCIASVKEIDNIITDKG 233
Cdd:COG1349  160 ALRRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAG 234
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 1-233 7.17e-86

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 255.83  E-value: 7.17e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015   1 MNPIKRRKHILDELNKFGEVTVIKLSEMLNVTSETIRRDLSLLESEGKITKIHGGAVKK-QVVQEDAFSARIEAHREEKI 79
Cdd:COG1349    1 MLAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVsSAAAEPPFAERETLNAEEKR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015  80 AIGKLAAEMVSERDTLFIDSCTTNLILAEQLPPLA-FSVITNSALIADKIKEHNlQARVYVLGGEYDYHFRANLGVSVCQ 158
Cdd:COG1349   81 AIARAAASLIEDGDTIFLDAGTTTLALARALPDRRnLTVVTNSLNIANELAERP-NIEVILLGGELRPSSGSLVGPLAEE 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 912086015 159 QINAIHADICFIGAGGISPQHGVLVKSFEEAYVAKAMIAMSKKSVILADHTKFGQDGVMCIASVKEIDNIITDKG 233
Cdd:COG1349  160 ALRRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAG 234
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 74-232 3.11e-49

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 159.21  E-value: 3.11e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015   74 HREEKIAIGKLAAEMVSERDTLFIDSCTTNLILAEQLPPLA-FSVITNSALIADKIKEHNlQARVYVLGGEYDYHFRANL 152
Cdd:pfam00455   2 NAEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRnLTVITNSLNIANELSEKP-DIEVILLGGEVRPKTGAFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015  153 GVSVCQQINAIHADICFIGAGGISPQHGVLVKSFEEAYVAKAMIAMSKKSVILADHTKFGQDGVMCIASVKEIDNIITDK 232
Cdd:pfam00455  81 GPLAEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITDK 160
TranRegGlpR_Halo NF041397
HTH-type transcriptional regulator GlpR;
1-232 1.12e-41

HTH-type transcriptional regulator GlpR;


Pssm-ID: 469288 [Multi-domain]  Cd Length: 253  Bit Score: 142.74  E-value: 1.12e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015   1 MNPIKRRKHILDELNKFGEVTVIKLSEMLNVTSETIRRDLSLLESEGKITKIHGGAVK-KQVVQEDAFSARIEAHREEKI 79
Cdd:NF041397   1 MLPEERKRKIVELVTERDGCSVEELADELDVSKATIRRDLRDLEDRGLIERSHGGAVPvTSVGRERSYGQREVQNLEAKR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015  80 AIGKLAAEMVSERDTLFIDSCTTNLILAEQLPP-LAFSVITNSALIADKIKEHNlqARVYVLGGEYDYHFRANLGVSVCQ 158
Cdd:NF041397  81 AIAERAVEEIHDGQVVFFDAGTTTMEVAKRVPTdGSFLAVTNSPLLALELAERD--GEVKLTGGTLRPRTRALVGPTAES 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 912086015 159 QINAIHADICFIGAGGISPQHGVLVKSFEEAYVAKAMIAMSKKSVILADHTKFGQDGVMCIASVKEIDNIITDK 232
Cdd:NF041397 159 FMERTNFDLLFLGTNGIDPDGGLTTPNEDEARMKELMVENAKRVVLVADGSKFGERSFVRFADLDDVDLFVTDG 232
srlR PRK10434
DNA-binding transcriptional repressor;
1-233 2.47e-33

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 121.33  E-value: 2.47e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015   1 MNPIKRRKHILDELNKFGEVTVIKLSEMLNVTSETIRRDLSLLESEGKITKIHGGAVKKQVVQEDAFSARIEAHREEKIA 80
Cdd:PRK10434   1 MKPRQRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKEESDPPIDHKTLINTHKKEL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015  81 IGKLAAEMVSERDTLFIDSCTTNLilaeQLPPL-----AFSVITNSALIADKIKEHNLQARVYVLGGEY---DYHFRANL 152
Cdd:PRK10434  81 IAEAAVSLIHDGDSIILDAGSTVL----QMVPLlsrfnNITVMTNSLHIVNALSELDNEQTILMPGGTFrkkSASFHGQL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015 153 GVSVCQQINaihADICFIGAGGISPQHGvlVKSFEEAY-VAKAMIAMSKKSVILADHTKFGQDGVMCIASVKEIDNIITD 231
Cdd:PRK10434 157 AENAFEHFT---FDKLFIGTDGIDLNAG--VTTFNEVYtVSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVDKLITD 231


                 ..
gi 912086015 232 KG 233
Cdd:PRK10434 232 AG 233
AgaR NF040755
transcriptional repressor AgaR;
1-249 8.86e-26

transcriptional repressor AgaR;


Pssm-ID: 468715 [Multi-domain]  Cd Length: 256  Bit Score: 101.58  E-value: 8.86e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015   1 MNPIKRRKHILDELNKFGEVTVIKLSEMLNVTSETIRRDLSLLESEGKITKIHGGAVKKqvvqeDAFSARIEAHREEKIA 80
Cdd:NF040755   2 KGTSERREQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGALIN-----DGFIPGAEPSVEDKSR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015  81 --------IGKLAAEMVSERDTLFIDSCTTNLILAEQLPPL-AFSVITNSALIADKIKEHNlQARVYVLGGeydyHFRAN 151
Cdd:NF040755  77 lntavkrlIAAAAAELIKPGDRVILDSGTTTYEIARHLKQHqDVVVMTNGLNVANELLEAE-GVEVLMTGG----HLRRQ 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015 152 ----LGVSVCQQINAIHADICFIGAGGISPQHGVLVKSFEEAYVAKAMIAMSKKSVILADHTKFGQDGVMCIASVKEIDN 227
Cdd:NF040755 152 slsfYGDQAEQSLQNYHFDKLFLGVDGFDLERGITTHNEDEARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDT 231

                        250       260
                 ....*....|....*....|..
gi 912086015 228 IITDKGFtstgytPQDFAGKLR 249
Cdd:NF040755 232 LITDSGI------PEEYLQGLR 247
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
6-57 6.91e-14

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 64.17  E-value: 6.91e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 912086015     6 RRKHILDELNKFGEVTVIKLSEMLNVTSETIRRDLSLLESEGKITKIHGGAV 57
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAV 52
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 21-54 2.25e-03

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 35.50  E-value: 2.25e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 912086015  21 TVIKLSEMLNVTSETIRRDLSLLESEGKITKIHG 54
Cdd:cd07377   27 SERELAEELGVSRTTVREALRELEAEGLVERRPG 60
 
Name Accession Description Interval E-value
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 1-233 7.17e-86

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 255.83  E-value: 7.17e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015   1 MNPIKRRKHILDELNKFGEVTVIKLSEMLNVTSETIRRDLSLLESEGKITKIHGGAVKK-QVVQEDAFSARIEAHREEKI 79
Cdd:COG1349    1 MLAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVsSAAAEPPFAERETLNAEEKR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015  80 AIGKLAAEMVSERDTLFIDSCTTNLILAEQLPPLA-FSVITNSALIADKIKEHNlQARVYVLGGEYDYHFRANLGVSVCQ 158
Cdd:COG1349   81 AIARAAASLIEDGDTIFLDAGTTTLALARALPDRRnLTVVTNSLNIANELAERP-NIEVILLGGELRPSSGSLVGPLAEE 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 912086015 159 QINAIHADICFIGAGGISPQHGVLVKSFEEAYVAKAMIAMSKKSVILADHTKFGQDGVMCIASVKEIDNIITDKG 233
Cdd:COG1349  160 ALRRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDAG 234
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
 74-232 3.11e-49

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 159.21  E-value: 3.11e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015   74 HREEKIAIGKLAAEMVSERDTLFIDSCTTNLILAEQLPPLA-FSVITNSALIADKIKEHNlQARVYVLGGEYDYHFRANL 152
Cdd:pfam00455   2 NAEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRRnLTVITNSLNIANELSEKP-DIEVILLGGEVRPKTGAFV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015  153 GVSVCQQINAIHADICFIGAGGISPQHGVLVKSFEEAYVAKAMIAMSKKSVILADHTKFGQDGVMCIASVKEIDNIITDK 232
Cdd:pfam00455  81 GPLAEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITDK 160
TranRegGlpR_Halo NF041397
HTH-type transcriptional regulator GlpR;
1-232 1.12e-41

HTH-type transcriptional regulator GlpR;


Pssm-ID: 469288 [Multi-domain]  Cd Length: 253  Bit Score: 142.74  E-value: 1.12e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015   1 MNPIKRRKHILDELNKFGEVTVIKLSEMLNVTSETIRRDLSLLESEGKITKIHGGAVK-KQVVQEDAFSARIEAHREEKI 79
Cdd:NF041397   1 MLPEERKRKIVELVTERDGCSVEELADELDVSKATIRRDLRDLEDRGLIERSHGGAVPvTSVGRERSYGQREVQNLEAKR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015  80 AIGKLAAEMVSERDTLFIDSCTTNLILAEQLPP-LAFSVITNSALIADKIKEHNlqARVYVLGGEYDYHFRANLGVSVCQ 158
Cdd:NF041397  81 AIAERAVEEIHDGQVVFFDAGTTTMEVAKRVPTdGSFLAVTNSPLLALELAERD--GEVKLTGGTLRPRTRALVGPTAES 158

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 912086015 159 QINAIHADICFIGAGGISPQHGVLVKSFEEAYVAKAMIAMSKKSVILADHTKFGQDGVMCIASVKEIDNIITDK 232
Cdd:NF041397 159 FMERTNFDLLFLGTNGIDPDGGLTTPNEDEARMKELMVENAKRVVLVADGSKFGERSFVRFADLDDVDLFVTDG 232
srlR PRK10434
DNA-binding transcriptional repressor;
1-233 2.47e-33

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 121.33  E-value: 2.47e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015   1 MNPIKRRKHILDELNKFGEVTVIKLSEMLNVTSETIRRDLSLLESEGKITKIHGGAVKKQVVQEDAFSARIEAHREEKIA 80
Cdd:PRK10434   1 MKPRQRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVLNKEESDPPIDHKTLINTHKKEL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015  81 IGKLAAEMVSERDTLFIDSCTTNLilaeQLPPL-----AFSVITNSALIADKIKEHNLQARVYVLGGEY---DYHFRANL 152
Cdd:PRK10434  81 IAEAAVSLIHDGDSIILDAGSTVL----QMVPLlsrfnNITVMTNSLHIVNALSELDNEQTILMPGGTFrkkSASFHGQL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015 153 GVSVCQQINaihADICFIGAGGISPQHGvlVKSFEEAY-VAKAMIAMSKKSVILADHTKFGQDGVMCIASVKEIDNIITD 231
Cdd:PRK10434 157 AENAFEHFT---FDKLFIGTDGIDLNAG--VTTFNEVYtVSKAMCNAAREIILMADSSKFGRKSPNVVCSLEKVDKLITD 231


                 ..
gi 912086015 232 KG 233
Cdd:PRK10434 232 AG 233
AgaR NF040755
transcriptional repressor AgaR;
1-249 8.86e-26

transcriptional repressor AgaR;


Pssm-ID: 468715 [Multi-domain]  Cd Length: 256  Bit Score: 101.58  E-value: 8.86e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015   1 MNPIKRRKHILDELNKFGEVTVIKLSEMLNVTSETIRRDLSLLESEGKITKIHGGAVKKqvvqeDAFSARIEAHREEKIA 80
Cdd:NF040755   2 KGTSERREQIIQRLRQQGSVQVEDLSALFGVSTVTIRNDLAFLEKQGIAVRAYGGALIN-----DGFIPGAEPSVEDKSR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015  81 --------IGKLAAEMVSERDTLFIDSCTTNLILAEQLPPL-AFSVITNSALIADKIKEHNlQARVYVLGGeydyHFRAN 151
Cdd:NF040755  77 lntavkrlIAAAAAELIKPGDRVILDSGTTTYEIARHLKQHqDVVVMTNGLNVANELLEAE-GVEVLMTGG----HLRRQ 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015 152 ----LGVSVCQQINAIHADICFIGAGGISPQHGVLVKSFEEAYVAKAMIAMSKKSVILADHTKFGQDGVMCIASVKEIDN 227
Cdd:NF040755 152 slsfYGDQAEQSLQNYHFDKLFLGVDGFDLERGITTHNEDEARLNRRMCEVAERIIAVTDSSKFGRSSLHKIRDTGRIDT 231

                        250       260
                 ....*....|....*....|..
gi 912086015 228 IITDKGFtstgytPQDFAGKLR 249
Cdd:NF040755 232 LITDSGI------PEEYLQGLR 247
PRK13509 PRK13509
HTH-type transcriptional regulator UlaR;
1-233 2.50e-25

HTH-type transcriptional regulator UlaR;


Pssm-ID: 184100 [Multi-domain]  Cd Length: 251  Bit Score: 100.08  E-value: 2.50e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015   1 MNPIKRRKHILDELNKFGEVTVIKLSEMLNVTSETIRRDLSLLESEGKITKIHGGA--VKKQVVQEDAFSARIEAHREEK 78
Cdd:PRK13509   1 MTEAQRHQILLELLAQLGFVTVEKVIERLGISPATARRDINKLDESGKLKKVRNGAeaITQQRPRWTPMNIHQAQNHDEK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015  79 IAIGKLAAEMVSERDTLFIDSCTTNLILAEQLPPLAFSVITNSALIADKIKEHNLQaRVYVLGGEydYHFRANLGVSVCQ 158
Cdd:PRK13509  81 VRIAKAASQLCNPGESVVINCGSTAFLLGRELCGKPVQIITNYLPLANYLIDQEHD-SVIIMGGQ--YNKSQSITLSPQG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015 159 QINAIHA-DICFIGAGGISPQhGVlvksfeeaYVAKAMIAMSK--------KSVILADHTKFGQDGVMCIASVKEIDNII 229
Cdd:PRK13509 158 SENSLYAgHWMFTSGKGLTAD-GL--------YKTDMLTAMAEqkmlsvvgKLVVLVDSSKIGERAGMLFSRADQIDMLI 228


                 ....
gi 912086015 230 TDKG 233
Cdd:PRK13509 229 TGKN 232
PRK10411 PRK10411
L-fucose operon activator;
6-232 1.61e-24

L-fucose operon activator;


Pssm-ID: 236684 [Multi-domain]  Cd Length: 240  Bit Score: 97.57  E-value: 1.61e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015   6 RRKHILDELNKFGEVTVIKLSEMLNVTSETIRRDLSLLESEGKITKIHGGAvkKQVVQE-----DAFSARIEAHREEKIA 80
Cdd:PRK10411   5 RQQAIVDLLLNHTSLTTEALAEQLNVSKETIRRDLNELQTQGKILRNHGRA--KYIHRQnqdsgDPFHIRLKSHYAHKAD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015  81 IGKLAAEMVSERDTLFIDSCTTNLILAEQLPPLAFSVITNSALIADKIKEHNlQARVYVLGGEYDYHFRANLGVSVCQQI 160
Cdd:PRK10411  83 IAREALAWIEEGMVIALDASSTCWYLARQLPDINIQVFTNSHPICQELGKRE-RIQLISSGGTLERKYGCYVNPSLISQL 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 912086015 161 NAIHADICFIGAGGISpQHGVLVKSFE-EAYVAKAMIAMSKKSVILADHTKFGQDGVMCIASVKEIDNIITDK 232
Cdd:PRK10411 162 KSLEIDLFIFSCEGID-SSGALWDSNAiNADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISDE 233
PRK10681 PRK10681
DNA-binding transcriptional repressor DeoR; Provisional
 28-231 5.66e-23

DNA-binding transcriptional repressor DeoR; Provisional


Pssm-ID: 182644 [Multi-domain]  Cd Length: 252  Bit Score: 93.99  E-value: 5.66e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015  28 MLNVTSETIRRDLSlleSEGKITKIHGGAV--KKQVVQEDAFSARIEAHREEKIAIGKLAAEMVSERDTLFIDSCTTNLI 105
Cdd:PRK10681  30 LLGVSEMTIRRDLN---AHSAPVVLLGGYIvlEPRSASHYLLSDQKSRLVEEKRRAAQLAATLVEPNQTLFFDCGTTTPW 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015 106 LAEQLP-PLAFSVITNS--ALIADKIKEHnlqARVYVLGGEY---DYHFRAnlgVSVCQQINAIHADICFIGAGGISPQH 179
Cdd:PRK10681 107 IIEAIDnELPFTAVCYSlnTFLALQEKPH---CRAILCGGEFhasNAIFKP---LDFQQTLDNICPDIAFYSAAGVHVSK 180

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 912086015 180 GVLVKSFEEAYVAKAMIAMSKKSVILADHTKFGQDGVMCIASVKEIDNIITD 231
Cdd:PRK10681 181 GATCFNLEELPVKHWAMAMAQKHVLVVDHSKFGKVRPARMGDLTRFDTVVSD 232
PRK09802 PRK09802
DeoR family transcriptional regulator;
5-233 1.00e-22

DeoR family transcriptional regulator;


Pssm-ID: 182086 [Multi-domain]  Cd Length: 269  Bit Score: 93.77  E-value: 1.00e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015   5 KRRKHILDELNKFGEVTVIKLSEMLNVTSETIRRDLSLLESEGKITKIHGGAV---KKQVVQEDAFSARIEAHREEKIAI 81
Cdd:PRK09802  17 ERREQIIQRLRQQGSVQVNDLSALYGVSTVTIRNDLAFLEKQGIAVRAYGGALicdSTTPSVEPSVEDKSALNTAMKRSV 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015  82 GKLAAEMVSERDTLFIDSCTTNLILAEQLPPLA-FSVITNSALIADKIKEhnlQARVYVL--GGEYDYHFRANLGVSVCQ 158
Cdd:PRK09802  97 AKAAVELIQPGHRVILDSGTTTFEIARLMRKHTdVIAMTNGMNVANALLE---AEGVELLmtGGHLRRQSQSFYGDQAEQ 173

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 912086015 159 QINAIHADICFIGAGGISPQHGVLVKSFEEAYVAKAMIAMSKKSVILADHTKFGQDGVMCIASVKEIDNIITDKG 233
Cdd:PRK09802 174 SLQNYHFDMLFLGVDAIDLERGVSTHNEDEARLNRRMCEVAERIIVVTDSSKFNRSSLHKIIDTQRIDMIIVDEG 248
PRK10906 PRK10906
DeoR/GlpR family transcriptional regulator;
1-232 1.49e-18

DeoR/GlpR family transcriptional regulator;


Pssm-ID: 182827 [Multi-domain]  Cd Length: 252  Bit Score: 81.83  E-value: 1.49e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015   1 MNPIKRRKHILDELNKFGEVTVIKLSEMLNVTSETIRRDLSLLESEGKITKIHGGAVKKQVVQEDAFSARIEAHREEKIA 80
Cdd:PRK10906   1 MKQTQRHDAIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNDLAEQNKILRHHGGAALPSSSVNTPWHDRKATQTEEKER 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 912086015  81 IGKLAAEMVSERDTLFIDSCTTNLILAEQLPPLA-FSVITNSALIADKI--KEhnlQARVYVLGGEYDYHFRANLGVSVC 157
Cdd:PRK10906  81 IARKVASQIPNGATLFIDIGTTPEAVAHALLNHSnLRIVTNNLNVANTLmaKE---DFRIILAGGELRSRDGGIIGEATL 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 912086015 158 QQINAIHADICFIGAGGISPQHGVLVKSFEEAYVAKAMIAMSKKSVILADHTKFGQDGVMCIASVKEIDNIITDK 232
Cdd:PRK10906 158 DFISQFRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDQ 232
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
6-57 6.91e-14

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 64.17  E-value: 6.91e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 912086015     6 RRKHILDELNKFGEVTVIKLSEMLNVTSETIRRDLSLLESEGKITKIHGGAV 57
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAV 52
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
6-57 5.60e-13

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 61.89  E-value: 5.60e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 912086015    6 RRKHILDELNKFGEVTVIKLSEMLNVTSETIRRDLSLLESEGKITKIHGGAV 57
Cdd:pfam08220   1 RIQQILELLKQQGTLSVEELAELLGVSEMTIRRDLNELEEQGLLTRTHGGAV 52
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
6-50 3.49e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 40.68  E-value: 3.49e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 912086015   6 RRKHILDELNKFGEVTVIKLSEMLNVTSETIRRDLSLLESEGKIT 50
Cdd:COG2345   14 TRRRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVE 58
Put_DNA-bind_N pfam06971
Putative DNA-binding protein N-terminus; This family represents the N-terminus (approximately ...
 9-41 2.09e-03

Putative DNA-binding protein N-terminus; This family represents the N-terminus (approximately 50 residues) of a number of putative bacterial DNA-binding proteins.


Pssm-ID: 429222 [Multi-domain]  Cd Length: 49  Bit Score: 35.12  E-value: 2.09e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 912086015    9 HILDELNKFGEVTV--IKLSEMLNVTSETIRRDLS 41
Cdd:pfam06971  15 RYLEELEEEGVERIssTELAEALGVTAAQVRKDLS 49
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 21-54 2.25e-03

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 35.50  E-value: 2.25e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 912086015  21 TVIKLSEMLNVTSETIRRDLSLLESEGKITKIHG 54
Cdd:cd07377   27 SERELAEELGVSRTTVREALRELEAEGLVERRPG 60
PRK05472 PRK05472
redox-sensing transcriptional repressor Rex; Provisional
 9-48 3.81e-03

redox-sensing transcriptional repressor Rex; Provisional


Pssm-ID: 235486 [Multi-domain]  Cd Length: 213  Bit Score: 37.40  E-value: 3.81e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 912086015   9 HILDELNKFGEVTV--IKLSEMLNVTSETIRRDLSLLESEGK 48
Cdd:PRK05472  20 RYLKELKEEGVERVssKELAEALGVDSAQIRKDLSYFGEFGK 61
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
25-54 5.28e-03

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 37.15  E-value: 5.28e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 912086015  25 LSEMLNVTSETIRRDLSLLESEGKITKIHG 54
Cdd:COG2188   35 LAEEFGVSRMTVRKALDELVEEGLLERRQG 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
21-57 6.53e-03

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 34.09  E-value: 6.53e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 912086015    21 TVIKLSEMLNVTSETIRRDLSLLESEGKITKIHGGAV 57
Cdd:smart00345  22 SERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGT 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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