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Conserved domains on  [gi|913483833|gb|KNY46631|]
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4-hydroxybenzoyl-CoA thioesterase [Vibrio harveyi]

Protein Classification

acyl-CoA thioesterase( domain architecture ID 10002786)

acyl-CoA thioesterase catalyzes the hydrolysis of acyl-CoA esters to the free fatty acid and CoA; belongs to the Hotdog fold superfamily

CATH:  3.10.129.10
EC:  3.1.2.-
Gene Ontology:  GO:0016790|GO:0016787
PubMed:  15307895

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FadM COG0824
Acyl-CoA thioesterase FadM [Lipid transport and metabolism]; Acyl-CoA thioesterase FadM is ...
 12-141 1.54e-29

Acyl-CoA thioesterase FadM [Lipid transport and metabolism]; Acyl-CoA thioesterase FadM is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440586 [Multi-domain]  Cd Length: 139  Bit Score: 104.59  E-value: 1.54e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913483833  12 EVTMVTSFQDADPMGVIYHGNFFRYFEEARRVLMEKIEYSYRDMQASGYMWPIIDTRVKYVKAIPFNHEIRITATLTEWE 91
Cdd:COG0824    7 ETPIRVRFGDTDAMGHVNNANYLRYFEEARTEFLRALGLSYAELEEEGIGLVVVEAEIDYLRPARYGDELTVETRVVRLG 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 913483833  92 N-RLRVDYVIYDAKTDQRMCKAHTTQVAVSIEKQEMCFVsPAAFLDKVEQW 141
Cdd:COG0824   87 GsSLTFEYEIFRADDGELLATGETVLVFVDLETGRPVPL-PDELRAALEAL 136
 
Name Accession Description Interval E-value
FadM COG0824
Acyl-CoA thioesterase FadM [Lipid transport and metabolism]; Acyl-CoA thioesterase FadM is ...
 12-141 1.54e-29

Acyl-CoA thioesterase FadM [Lipid transport and metabolism]; Acyl-CoA thioesterase FadM is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440586 [Multi-domain]  Cd Length: 139  Bit Score: 104.59  E-value: 1.54e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913483833  12 EVTMVTSFQDADPMGVIYHGNFFRYFEEARRVLMEKIEYSYRDMQASGYMWPIIDTRVKYVKAIPFNHEIRITATLTEWE 91
Cdd:COG0824    7 ETPIRVRFGDTDAMGHVNNANYLRYFEEARTEFLRALGLSYAELEEEGIGLVVVEAEIDYLRPARYGDELTVETRVVRLG 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 913483833  92 N-RLRVDYVIYDAKTDQRMCKAHTTQVAVSIEKQEMCFVsPAAFLDKVEQW 141
Cdd:COG0824   87 GsSLTFEYEIFRADDGELLATGETVLVFVDLETGRPVPL-PDELRAALEAL 136
4HBT cd00586
4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate ...
 12-120 5.83e-24

4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites. There is no evidence to suggest that 4HBT is related to the type I thioesterases functioning in primary or secondary metabolic pathways. Each subunit of the 4HBT tetramer adopts a so-called hot-dog fold similar to those of beta-hydroxydecanoyl-ACP dehydratase, (R)-specific enoyl-CoA hydratase, and type II, thioesterase (TEII).


Pssm-ID: 238329 [Multi-domain]  Cd Length: 110  Bit Score: 89.20  E-value: 5.83e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913483833  12 EVTMVTSFQDADPMGVIYHGNFFRYFEEARRVLMEKIEYSYRDMQASGYMWPIIDTRVKYVKAIPFNHEIRITATLTEWE 91
Cdd:cd00586    2 TLEIRVRFGDTDAAGHVNNARYLRYFEEAREEFLRELGLGYDELEEQGLGLVVVELEIDYLRPLRLGDRLTVETRVLRLG 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 913483833  92 N-RLRVDYVIYDAkTDQRMCKAHTTQVAVS 120
Cdd:cd00586   82 RkSFTFEQEIFRE-DGELLATAETVLVCVD 110
4HBT_2 pfam13279
Thioesterase-like superfamily; This family contains a wide variety of enzymes, principally ...
 19-117 7.50e-12

Thioesterase-like superfamily; This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily.


Pssm-ID: 463826  Cd Length: 121  Bit Score: 58.51  E-value: 7.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913483833   19 FQDADPMGVIYHGNFFRYFEEARRVLMEKIEYSYRDMQASGYMWPIIDTRVKYVKAIPFNHEIRITATLTEW-ENRLRVD 97
Cdd:pfam13279   3 PGDIDANGHMNNARYLRYFEEARDRFLERLGLDLAYREALGIGLILAEAHVRYRRELKLGDELTVETRLIDWdAKRFHLE 82

                          90       100
                  ....*....|....*....|
gi 913483833   98 YVIYDAkTDQRMCKAHTTQV 117
Cdd:pfam13279  83 HRFLSP-DGKLVATAETRLV 101
TIGR00051 TIGR00051
acyl-CoA thioester hydrolase, YbgC/YbaW family; This model describes a subset of related ...
 19-89 3.71e-08

acyl-CoA thioester hydrolase, YbgC/YbaW family; This model describes a subset of related acyl-CoA thioesterases that include several at least partially characterized proteins. YbgC is an acyl-CoA thioesterase associated with the Tol-Pal system. YbaW is part of the FadM regulon. [Unknown function, General]


Pssm-ID: 129161 [Multi-domain]  Cd Length: 117  Bit Score: 48.57  E-value: 3.71e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 913483833   19 FQDADPMGVIYHGNFFRYFEEARRVLMEKIEYSYRDMQASGYMWPIIDTRVKYVKAIPFNHEIRITATLTE 89
Cdd:TIGR00051   6 YEDTDAQGIVYHANYLRYCERARTEFLRSLGFPQSVLRAEGVAFVVVNINIEYKKPARLDDVLEIRTQIEE 76
 
Name Accession Description Interval E-value
FadM COG0824
Acyl-CoA thioesterase FadM [Lipid transport and metabolism]; Acyl-CoA thioesterase FadM is ...
 12-141 1.54e-29

Acyl-CoA thioesterase FadM [Lipid transport and metabolism]; Acyl-CoA thioesterase FadM is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440586 [Multi-domain]  Cd Length: 139  Bit Score: 104.59  E-value: 1.54e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913483833  12 EVTMVTSFQDADPMGVIYHGNFFRYFEEARRVLMEKIEYSYRDMQASGYMWPIIDTRVKYVKAIPFNHEIRITATLTEWE 91
Cdd:COG0824    7 ETPIRVRFGDTDAMGHVNNANYLRYFEEARTEFLRALGLSYAELEEEGIGLVVVEAEIDYLRPARYGDELTVETRVVRLG 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 913483833  92 N-RLRVDYVIYDAKTDQRMCKAHTTQVAVSIEKQEMCFVsPAAFLDKVEQW 141
Cdd:COG0824   87 GsSLTFEYEIFRADDGELLATGETVLVFVDLETGRPVPL-PDELRAALEAL 136
4HBT cd00586
4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate ...
 12-120 5.83e-24

4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites. There is no evidence to suggest that 4HBT is related to the type I thioesterases functioning in primary or secondary metabolic pathways. Each subunit of the 4HBT tetramer adopts a so-called hot-dog fold similar to those of beta-hydroxydecanoyl-ACP dehydratase, (R)-specific enoyl-CoA hydratase, and type II, thioesterase (TEII).


Pssm-ID: 238329 [Multi-domain]  Cd Length: 110  Bit Score: 89.20  E-value: 5.83e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913483833  12 EVTMVTSFQDADPMGVIYHGNFFRYFEEARRVLMEKIEYSYRDMQASGYMWPIIDTRVKYVKAIPFNHEIRITATLTEWE 91
Cdd:cd00586    2 TLEIRVRFGDTDAAGHVNNARYLRYFEEAREEFLRELGLGYDELEEQGLGLVVVELEIDYLRPLRLGDRLTVETRVLRLG 81

                         90       100       110
                 ....*....|....*....|....*....|
gi 913483833  92 N-RLRVDYVIYDAkTDQRMCKAHTTQVAVS 120
Cdd:cd00586   82 RkSFTFEQEIFRE-DGELLATAETVLVCVD 110
4HBT_2 pfam13279
Thioesterase-like superfamily; This family contains a wide variety of enzymes, principally ...
 19-117 7.50e-12

Thioesterase-like superfamily; This family contains a wide variety of enzymes, principally thioesterases. These enzymes are part of the Hotdog fold superfamily.


Pssm-ID: 463826  Cd Length: 121  Bit Score: 58.51  E-value: 7.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913483833   19 FQDADPMGVIYHGNFFRYFEEARRVLMEKIEYSYRDMQASGYMWPIIDTRVKYVKAIPFNHEIRITATLTEW-ENRLRVD 97
Cdd:pfam13279   3 PGDIDANGHMNNARYLRYFEEARDRFLERLGLDLAYREALGIGLILAEAHVRYRRELKLGDELTVETRLIDWdAKRFHLE 82

                          90       100
                  ....*....|....*....|
gi 913483833   98 YVIYDAkTDQRMCKAHTTQV 117
Cdd:pfam13279  83 HRFLSP-DGKLVATAETRLV 101
TIGR00051 TIGR00051
acyl-CoA thioester hydrolase, YbgC/YbaW family; This model describes a subset of related ...
 19-89 3.71e-08

acyl-CoA thioester hydrolase, YbgC/YbaW family; This model describes a subset of related acyl-CoA thioesterases that include several at least partially characterized proteins. YbgC is an acyl-CoA thioesterase associated with the Tol-Pal system. YbaW is part of the FadM regulon. [Unknown function, General]


Pssm-ID: 129161 [Multi-domain]  Cd Length: 117  Bit Score: 48.57  E-value: 3.71e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 913483833   19 FQDADPMGVIYHGNFFRYFEEARRVLMEKIEYSYRDMQASGYMWPIIDTRVKYVKAIPFNHEIRITATLTE 89
Cdd:TIGR00051   6 YEDTDAQGIVYHANYLRYCERARTEFLRSLGFPQSVLRAEGVAFVVVNINIEYKKPARLDDVLEIRTQIEE 76
4HBT pfam03061
Thioesterase superfamily; This family contains a wide variety of enzymes, principally ...
 25-104 2.14e-05

Thioesterase superfamily; This family contains a wide variety of enzymes, principally thioesterases. This family includes 4HBT (EC 3.1.2.23) which catalyzes the final step in the biosynthesis of 4-hydroxybenzoate from 4-chlorobenzoate in the soil dwelling microbe Pseudomonas CBS-3. This family includes various cytosolic long-chain acyl-CoA thioester hydrolases. Long-chain acyl-CoA hydrolases hydrolyse palmitoyl-CoA to CoA and palmitate, they also catalyze the hydrolysis of other long chain fatty acyl-CoA thioesters.


Pssm-ID: 427116 [Multi-domain]  Cd Length: 79  Bit Score: 40.32  E-value: 2.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 913483833   25 MGVIYHGNFFRYFEEARRVLMEKIEYSYRDMqasgymwPIIDTRVKYVKAIPFNHEIRITATLTEWENR-LRVDYVIYDA 103
Cdd:pfam03061   1 GGVVHGGVYLALADEAAGAAARRLGGSQQVV-------VVVELSIDFLRPARLGDRLTVEARVVRLGRTsAVVEVEVRDE 73


                  .
gi 913483833  104 K 104
Cdd:pfam03061  74 D 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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