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Conserved domains on  [gi|930309252|gb|KPH96724|]
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histidine kinase [Pseudoalteromonas porphyrae]

Protein Classification

sensor histidine kinase( domain architecture ID 11472018)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals; similar to FlgS and FleS

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0000156|GO:0005524|GO:0007165|GO:0004673|GO:0000155
PubMed:  10339418|10637609
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 26-426 1.84e-67

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


:

Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 220.60  E-value: 1.84e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252  26 AALGCYFIGQYFALSVVTstVISSLFLAIYL-KLFTRTYKKVINsfnrnhaHLDAILNEDYNQLVKPSYQaGSIHKLQQS 104
Cdd:COG5000    1 SGLQILFLLLLLLIALLL--LLLALWLALLLaRRLTRPLRRLAE-------ATRAVAAGDLSVRLPVTGD-DEIGELARA 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 105 LIELSEELFKKKSRYDQHVFLVYQLIEHFNVPIMVLDQHNKLSYANNAFSEF---------KQTQWQTLRYTSAEQLGLT 175
Cdd:COG5000   71 FNRMTDQLKEQREELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLlgipleeliGKPLEELLPELDLAELLRE 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 176 KQGAHWQFSDVIT---AQQWQIRHSEFIEQGschQLIVMIDITSALRENQLQAWQQIIRVLGHEIRNSLTPVTAMAENLA 252
Cdd:COG5000  151 ALERGWQEEIELTrdgRRTLLVRASPLRDDG---YVIVFDDITELLRAERLAAWGELARRIAHEIKNPLTPIQLSAERLR 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 253 VKLTE------PRQVQALNVISERCNYLNEFVTRYGDINKPLTLNIVEIDTAAFLKQVCAIYP--------DVEFSCVTN 318
Cdd:COG5000  228 RKLADkleedrEDLERALDTIIRQVDRLKRIVDEFLDFARLPEPQLEPVDLNELLREVLALYEpalkekdiRLELDLDPD 307

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 319 ATTFKADRTFIHQVMINLVKNAIEASIPPIKIALSVHNQGKVNCITIDDNGQGLANP--DNIFVPFYTTKQQGQGIGLSF 396
Cdd:COG5000  308 LPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEvlERIFEPFFTTKPKGTGLGLAI 387

                        410       420       430
                 ....*....|....*....|....*....|
gi 930309252 397 CRNVIEQHHGSLSLINkNKTQGVIATVLLP 426
Cdd:COG5000  388 VKKIVEEHGGTIELES-RPGGGTTFTIRLP 416
 
Name Accession Description Interval E-value
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 26-426 1.84e-67

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 220.60  E-value: 1.84e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252  26 AALGCYFIGQYFALSVVTstVISSLFLAIYL-KLFTRTYKKVINsfnrnhaHLDAILNEDYNQLVKPSYQaGSIHKLQQS 104
Cdd:COG5000    1 SGLQILFLLLLLLIALLL--LLLALWLALLLaRRLTRPLRRLAE-------ATRAVAAGDLSVRLPVTGD-DEIGELARA 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 105 LIELSEELFKKKSRYDQHVFLVYQLIEHFNVPIMVLDQHNKLSYANNAFSEF---------KQTQWQTLRYTSAEQLGLT 175
Cdd:COG5000   71 FNRMTDQLKEQREELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLlgipleeliGKPLEELLPELDLAELLRE 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 176 KQGAHWQFSDVIT---AQQWQIRHSEFIEQGschQLIVMIDITSALRENQLQAWQQIIRVLGHEIRNSLTPVTAMAENLA 252
Cdd:COG5000  151 ALERGWQEEIELTrdgRRTLLVRASPLRDDG---YVIVFDDITELLRAERLAAWGELARRIAHEIKNPLTPIQLSAERLR 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 253 VKLTE------PRQVQALNVISERCNYLNEFVTRYGDINKPLTLNIVEIDTAAFLKQVCAIYP--------DVEFSCVTN 318
Cdd:COG5000  228 RKLADkleedrEDLERALDTIIRQVDRLKRIVDEFLDFARLPEPQLEPVDLNELLREVLALYEpalkekdiRLELDLDPD 307

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 319 ATTFKADRTFIHQVMINLVKNAIEASIPPIKIALSVHNQGKVNCITIDDNGQGLANP--DNIFVPFYTTKQQGQGIGLSF 396
Cdd:COG5000  308 LPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEvlERIFEPFFTTKPKGTGLGLAI 387

                        410       420       430
                 ....*....|....*....|....*....|
gi 930309252 397 CRNVIEQHHGSLSLINkNKTQGVIATVLLP 426
Cdd:COG5000  388 VKKIVEEHGGTIELES-RPGGGTTFTIRLP 416
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 324-426 7.42e-24

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 95.41  E-value: 7.42e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252   324 ADRTFIHQVMINLVKNAIEASIPPIKIALSVHNQGKVNCITIDDNGQGLA--NPDNIFVPFYTTKQ-----QGQGIGLSF 396
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPpeDLEKIFEPFFRTDKrsrkiGGTGLGLSI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 930309252   397 CRNVIEQHHGSLSLINKNKtQGVIATVLLP 426
Cdd:smart00387  81 VKKLVELHGGEISVESEPG-GGTTFTITLP 109
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 329-425 7.46e-22

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 89.58  E-value: 7.46e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 329 IHQVMINLVKNAIEASIPPIKIALSVHNQGKVNCITIDDNGQGLA--NPDNIFVPFYTTKQ----QGQGIGLSFCRNVIE 402
Cdd:cd00075    1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPeeDLERIFERFYRGDKsregGGTGLGLAIVRRIVE 80

                         90       100
                 ....*....|....*....|...
gi 930309252 403 QHHGSLSLINKNkTQGVIATVLL 425
Cdd:cd00075   81 AHGGRITVESEP-GGGTTFTVTL 102
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
235-426 1.28e-19

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 90.62  E-value: 1.28e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 235 HEIRNSLTPVTAMAENLAVKLTEPRQVQAL-NVISERCNYLNEFVTRYGDINKPLTLNIVEIDTAAFLKQVC------AI 307
Cdd:PRK10364 246 HEIRNPLSSIKGLAKYFAERAPAGGEAHQLaQVMAKEADRLNRVVSELLELVKPTHLALQAVDLNDLINHSLqlvsqdAN 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 308 YPDVEFSCVTNAT--TFKADRTFIHQVMINLVKNAIEASIPPIKIALSVHNQGKVNCITIDDNGQGLANP--DNIFVPFY 383
Cdd:PRK10364 326 SREIQLRFTANDTlpEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADqlEAIFTPYF 405

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 930309252 384 TTKQQGQGIGLSFCRNVIEQHHGSLSlINKNKTQGVIATVLLP 426
Cdd:PRK10364 406 TTKAEGTGLGLAVVHNIVEQHGGTIQ-VASQEGKGATFTLWLP 447
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 324-426 6.77e-19

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 81.65  E-value: 6.77e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252  324 ADRTFIHQVMINLVKNAIEASIPPIKIALSVHNQGKVnCITIDDNGQGLANPD--NIFVPFYT---TKQQGQGIGLSFCR 398
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGEL-TLTVEDNGIGIPPEDlpRIFEPFSTadkRGGGGTGLGLSIVR 79

                          90       100
                  ....*....|....*....|....*...
gi 930309252  399 NVIEQHHGSLSLINKnKTQGVIATVLLP 426
Cdd:pfam02518  80 KLVELLGGTITVESE-PGGGTTVTLTLP 106
 
Name Accession Description Interval E-value
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 26-426 1.84e-67

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 220.60  E-value: 1.84e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252  26 AALGCYFIGQYFALSVVTstVISSLFLAIYL-KLFTRTYKKVINsfnrnhaHLDAILNEDYNQLVKPSYQaGSIHKLQQS 104
Cdd:COG5000    1 SGLQILFLLLLLLIALLL--LLLALWLALLLaRRLTRPLRRLAE-------ATRAVAAGDLSVRLPVTGD-DEIGELARA 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 105 LIELSEELFKKKSRYDQHVFLVYQLIEHFNVPIMVLDQHNKLSYANNAFSEF---------KQTQWQTLRYTSAEQLGLT 175
Cdd:COG5000   71 FNRMTDQLKEQREELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLlgipleeliGKPLEELLPELDLAELLRE 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 176 KQGAHWQFSDVIT---AQQWQIRHSEFIEQGschQLIVMIDITSALRENQLQAWQQIIRVLGHEIRNSLTPVTAMAENLA 252
Cdd:COG5000  151 ALERGWQEEIELTrdgRRTLLVRASPLRDDG---YVIVFDDITELLRAERLAAWGELARRIAHEIKNPLTPIQLSAERLR 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 253 VKLTE------PRQVQALNVISERCNYLNEFVTRYGDINKPLTLNIVEIDTAAFLKQVCAIYP--------DVEFSCVTN 318
Cdd:COG5000  228 RKLADkleedrEDLERALDTIIRQVDRLKRIVDEFLDFARLPEPQLEPVDLNELLREVLALYEpalkekdiRLELDLDPD 307

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 319 ATTFKADRTFIHQVMINLVKNAIEASIPPIKIALSVHNQGKVNCITIDDNGQGLANP--DNIFVPFYTTKQQGQGIGLSF 396
Cdd:COG5000  308 LPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEvlERIFEPFFTTKPKGTGLGLAI 387

                        410       420       430
                 ....*....|....*....|....*....|
gi 930309252 397 CRNVIEQHHGSLSLINkNKTQGVIATVLLP 426
Cdd:COG5000  388 VKKIVEEHGGTIELES-RPGGGTTFTIRLP 416
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
128-426 2.60e-38

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 141.91  E-value: 2.60e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 128 QLIEHFNVPIMVLDQHNKLSYANNAFSEFKQTQWQTLRYTSAEQLGLTKQGAHWQFSDVITAQQWQIRH---------SE 198
Cdd:COG3852   11 AILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFPEDSPLRELLERALAEGQPVTERevtlrrkdgEE 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 199 FI----------EQGSCHQLIVMIDITSALR-ENQLQAWQQ------IIRVLGHEIRNSLTPVTAMAENLAVKLTEPRQV 261
Cdd:COG3852   91 RPvdvsvsplrdAEGEGGVLLVLRDITERKRlERELRRAEKlaavgeLAAGLAHEIRNPLTGIRGAAQLLERELPDDELR 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 262 QALNVISERCNYLNEFVTRYGDINKPLTLNIVEIDTAAFLKQVCAI----YP---DVEFSCVTNATTFKADRTFIHQVMI 334
Cdd:COG3852  171 EYTQLIIEEADRLNNLVDRLLSFSRPRPPEREPVNLHEVLERVLELlraeAPkniRIVRDYDPSLPEVLGDPDQLIQVLL 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 335 NLVKNAIEAsIPP---IKIALSVHNQGKVN--------CITIDDNGQGLanP----DNIFVPFYTTKQQGQGIGLSFCRN 399
Cdd:COG3852  251 NLVRNAAEA-MPEggtITIRTRVERQVTLGglrprlyvRIEVIDNGPGI--PeeilDRIFEPFFTTKEKGTGLGLAIVQK 327

                        330       340
                 ....*....|....*....|....*..
gi 930309252 400 VIEQHHGSLSLINKnKTQGVIATVLLP 426
Cdd:COG3852  328 IVEQHGGTIEVESE-PGKGTTFRIYLP 353
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
217-426 1.17e-33

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 126.17  E-value: 1.17e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 217 ALRE-NQLQAwqQIIRVLGHEIRNSLTPVTAMAENLA--VKLTEPRQVQALNVISERCNYLNEFVTRYGDINK----PLT 289
Cdd:COG2205    8 ELEElERLKS--EFLANVSHELRTPLTSILGAAELLLdeEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRlesgKLS 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 290 LNIVEIDTAAFLKQVCAIY--------PDVEFSCVTNATTFKADRTFIHQVMINLVKNAIEASIPPIKIALSVHNQGKVN 361
Cdd:COG2205   86 LELEPVDLAELLEEAVEELrplaeekgIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGV 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 930309252 362 CITIDDNGQGLANPD--NIFVPFY----TTKQQGQGIGLSFCRNVIEQHHGSLSLINkNKTQGVIATVLLP 426
Cdd:COG2205  166 RISVSDNGPGIPEEEleRIFERFYrgdnSRGEGGTGLGLAIVKRIVEAHGGTIWVES-EPGGGTTFTVTLP 235
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
208-426 7.13e-32

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 123.48  E-value: 7.13e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 208 LIVMIDITSALRENQLQAWQQIIRVLGHEIRNSLTPVTAMAEnLAVKLTEPRQVQALNVISERCNYLNEFVTRYGDINK- 286
Cdd:COG0642   92 LLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLE-LLLEELDEEQREYLETILRSADRLLRLINDLLDLSRl 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 287 ---PLTLNIVEIDTAAFLKQVCAIY--------PDVEFSCVTNATTFKADRTFIHQVMINLVKNAIEASIPPIKIALSVH 355
Cdd:COG0642  171 eagKLELEPEPVDLAELLEEVVELFrplaeekgIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSVR 250

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 930309252 356 NQGKVNCITIDDNGQGLA--NPDNIFVPFYTTK----QQGQGIGLSFCRNVIEQHHGSLSLINkNKTQGVIATVLLP 426
Cdd:COG0642  251 REGDRVRISVEDTGPGIPpeDLERIFEPFFRTDpsrrGGGTGLGLAIVKRIVELHGGTIEVES-EPGKGTTFTVTLP 326
KinC COG5807
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ...
 218-426 2.18e-26

Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444509 [Multi-domain]  Cd Length: 358  Bit Score: 109.10  E-value: 2.18e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 218 LRENQLQAWQQIIRVLGHEIRNSLTPVTAMAENLAVKLTEPRQVQALNVISERCNYLNEFVTRYGDINKPLTLNIVEIDT 297
Cdd:COG5807  139 LRSEKLSVAGELAAGIAHEIRNPLTSIKGFLQLLQESREDSEREEYFNIIISEIDRINTIITELLVLSKPKKFNFKKLNL 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 298 AAFLKQVCAIYP--------DVEFSCVTNATTFKADRTFIHQVMINLVKNAIEASIPPIKIALSVHNQGKVNCITIDDNG 369
Cdd:COG5807  219 NDVLEDVIALLSteailkniSIKYDLADDEPVINGDKNQLKQVFINLIKNAIEAMETGGNITIKTYVEGDFVVISVKDEG 298

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 930309252 370 QGL--ANPDNIFVPFYTTKQQGQGIGLSFCRNVIEQHHGSLSLINKnKTQGVIATVLLP 426
Cdd:COG5807  299 IGIpeEVLEKIGEPFFTTKEEGTGLGLSICKKIIEEHNGTIEVESK-PGKGTTFTIYLP 356
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 235-426 5.44e-25

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 105.27  E-value: 5.44e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 235 HEIRNSLTPVTAMAENLAVKLTEPRQV----QALNVISERCNY-------LNEFVTRYGDINKPLTLN-IVEiDTAAFLK 302
Cdd:COG4191  151 HEINNPLAAILGNAELLRRRLEDEPDPeelrEALERILEGAERaaeivrsLRAFSRRDEEEREPVDLNeLID-EALELLR 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 303 QVCAIYP-DVEFSCVTNATTFKADRTFIHQVMINLVKNAIEA--SIPPIKIALSVHNQGKVNCITIDDNGQGLA--NPDN 377
Cdd:COG4191  230 PRLKARGiEVELDLPPDLPPVLGDPGQLEQVLLNLLINAIDAmeEGEGGRITISTRREGDYVVISVRDNGPGIPpeVLER 309

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 930309252 378 IFVPFYTTKQQGQ--GIGLSFCRNVIEQHHGSLSLINkNKTQGVIATVLLP 426
Cdd:COG4191  310 IFEPFFTTKPVGKgtGLGLSISYGIVEKHGGRIEVES-EPGGGTTFTITLP 359
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
213-426 5.71e-25

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 105.40  E-value: 5.71e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 213 DITSALRENQLQawQQIIRVLGHEIRnslTPVTAM---AENL--AVKLTEPRQVQALNVISERCNYLNEFVtryGDI--- 284
Cdd:COG5002  154 DITELERLEQMR--REFVANVSHELR---TPLTSIrgyLELLldGAADDPEERREYLEIILEEAERLSRLV---NDLldl 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 285 ----NKPLTLNIVEIDTAAFLKQVCAIYP--------DVEFSCVTNATTFKADRTFIHQVMINLVKNAIEASIPPIKIAL 352
Cdd:COG5002  226 srleSGELKLEKEPVDLAELLEEVVEELRplaeekgiELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITV 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 353 SVHNQGKVNCITIDDNGQGLANPD--NIFVPFYTT------KQQGQGIGLSFCRNVIEQHHGSLSLINKnKTQGVIATVL 424
Cdd:COG5002  306 SLREEDDQVRISVRDTGIGIPEEDlpRIFERFYRVdksrsrETGGTGLGLAIVKHIVEAHGGRIWVESE-PGKGTTFTIT 384


                 ..
gi 930309252 425 LP 426
Cdd:COG5002  385 LP 386
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 324-426 7.42e-24

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 95.41  E-value: 7.42e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252   324 ADRTFIHQVMINLVKNAIEASIPPIKIALSVHNQGKVNCITIDDNGQGLA--NPDNIFVPFYTTKQ-----QGQGIGLSF 396
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPpeDLEKIFEPFFRTDKrsrkiGGTGLGLSI 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 930309252   397 CRNVIEQHHGSLSLINKNKtQGVIATVLLP 426
Cdd:smart00387  81 VKKLVELHGGEISVESEPG-GGTTFTITLP 109
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 208-408 3.97e-22

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 98.12  E-value: 3.97e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 208 LIVMIDITS------ALRENQ-LQAWQQIIRVLGHEIRNSLTPVTAMAENLAVKLTEpRQVQALNVISERCNYLNEFVTR 280
Cdd:COG5809  245 VIIFRDITErkkleeLLRKSEkLSVVGELAAGIAHEIRNPLTSLKGFIQLLKDTIDE-EQKTYLDIMLSELDRIESIISE 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 281 YGDINKPLTLNIVEIDTAAFLKQVC------AIYPDVEFSCVTNATT--FKADRTFIHQVMINLVKNAIEAsIPP---IK 349
Cdd:COG5809  324 FLVLAKPQAIKYEPKDLNTLIEEVIpllqpqALLKNVQIELELEDDIpdILGDENQLKQVFINLLKNAIEA-MPEggnIT 402

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 930309252 350 IALSVHNQGKVNcITIDDNGQGLANP--DNIFVPFYTTKQQGQGIGLSFCRNVIEQHHGSL 408
Cdd:COG5809  403 IETKAEDDDKVV-ISVTDEGCGIPEErlKKLGEPFYTTKEKGTGLGLMVSYKIIEEHGGKI 462
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 329-425 7.46e-22

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 89.58  E-value: 7.46e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 329 IHQVMINLVKNAIEASIPPIKIALSVHNQGKVNCITIDDNGQGLA--NPDNIFVPFYTTKQ----QGQGIGLSFCRNVIE 402
Cdd:cd00075    1 LEQVLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPeeDLERIFERFYRGDKsregGGTGLGLAIVRRIVE 80

                         90       100
                 ....*....|....*....|...
gi 930309252 403 QHHGSLSLINKNkTQGVIATVLL 425
Cdd:cd00075   81 AHGGRITVESEP-GGGTTFTVTL 102
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
235-426 1.28e-19

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 90.62  E-value: 1.28e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 235 HEIRNSLTPVTAMAENLAVKLTEPRQVQAL-NVISERCNYLNEFVTRYGDINKPLTLNIVEIDTAAFLKQVC------AI 307
Cdd:PRK10364 246 HEIRNPLSSIKGLAKYFAERAPAGGEAHQLaQVMAKEADRLNRVVSELLELVKPTHLALQAVDLNDLINHSLqlvsqdAN 325

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 308 YPDVEFSCVTNAT--TFKADRTFIHQVMINLVKNAIEASIPPIKIALSVHNQGKVNCITIDDNGQGLANP--DNIFVPFY 383
Cdd:PRK10364 326 SREIQLRFTANDTlpEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDSGKGIAADqlEAIFTPYF 405

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 930309252 384 TTKQQGQGIGLSFCRNVIEQHHGSLSlINKNKTQGVIATVLLP 426
Cdd:PRK10364 406 TTKAEGTGLGLAVVHNIVEQHGGTIQ-VASQEGKGATFTLWLP 447
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
235-426 2.52e-19

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 90.41  E-value: 2.52e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 235 HEIRNSLTPVTAMAENLAVKLTEPRQVQALNVISERCNYLNEFVTRYGDINKP-------LTLNIVeIDTAAFLKQVCAI 307
Cdd:PRK11360 399 HEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPresqwqpVSLNAL-VEEVLQLFQTAGV 477

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 308 YPDVEFSCVTNAT--TFKADRTFIHQVMINLVKNAIEASIPPIKIALSVHNQGKVN-CITIDDNGQGLA--NPDNIFVPF 382
Cdd:PRK11360 478 QARVDFETELDNElpPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDGQvAVSIEDNGCGIDpeLLKKIFDPF 557

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 930309252 383 YTTKQQGQGIGLSFCRNVIEQHHGSL---SLINKnktqGVIATVLLP 426
Cdd:PRK11360 558 FTTKAKGTGLGLALSQRIINAHGGDIeveSEPGV----GTTFTLYLP 600
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 233-426 3.00e-19

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 89.79  E-value: 3.00e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 233 LGHEIRNSLTPVTAMAENLAVKLTEprQVQALNVISERCNYLNEFVTRYGDINKPL-----TLNIVEI--DTAAFLkQVC 305
Cdd:COG5805  294 IAHEIRNPLTSIKGFLQLLQPGIED--KEEYFDIMLSELDRIESIISEFLALAKPQavnkeKENINELiqDVVTLL-ETE 370

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 306 AIYPDVEFSCVTNATTFK--ADRTFIHQVMINLVKNAIEASIPPIKIALSVHNQGKVNCITIDDNGQGLanPDN----IF 379
Cdd:COG5805  371 AILHNIQIRLELLDEDPFiyCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGI--PEErlkkLG 448

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 930309252 380 VPFYTTKQQGQGIGLSFCRNVIEQHHGSLSlINKNKTQGVIATVLLP 426
Cdd:COG5805  449 EPFFTTKEKGTGLGLMVSYKIIENHNGTID-IDSKVGKGTTFTITLP 494
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 329-426 3.94e-19

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 82.06  E-value: 3.94e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 329 IHQVMINLVKNAIEA--SIPP----IKIALSVHNQGKVNcITIDDNGQGLAN--PDNIFVPFYTTKQQGQGIGLSFCRNV 400
Cdd:cd16920    1 IQQVLINLVRNGIEAmsEGGCerreLTIRTSPADDRAVT-ISVKDTGPGIAEevAGQLFDPFYTTKSEGLGMGLSICRSI 79

                         90       100
                 ....*....|....*....|....*.
gi 930309252 401 IEQHHGSLSlINKNKTQGVIATVLLP 426
Cdd:cd16920   80 IEAHGGRLS-VESPAGGGATFQFTLP 104
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 324-426 6.77e-19

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 81.65  E-value: 6.77e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252  324 ADRTFIHQVMINLVKNAIEASIPPIKIALSVHNQGKVnCITIDDNGQGLANPD--NIFVPFYT---TKQQGQGIGLSFCR 398
Cdd:pfam02518   1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGEL-TLTVEDNGIGIPPEDlpRIFEPFSTadkRGGGGTGLGLSIVR 79

                          90       100
                  ....*....|....*....|....*...
gi 930309252  399 NVIEQHHGSLSLINKnKTQGVIATVLLP 426
Cdd:pfam02518  80 KLVELLGGTITVESE-PGGGTTVTLTLP 106
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 323-410 1.11e-16

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 82.04  E-value: 1.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 323 KADRTFIHQVMINLVKNAIEASIPPIKIALSVHNQGKVNCITIDDNGQGLANPDNIFVPFYTTKQQGQGIGLSFCRNVIE 402
Cdd:COG4192  538 QGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNGWPLVDKLFTPFTTTKEVGLGLGLSICRSIMQ 617


                 ....*...
gi 930309252 403 QHHGSLSL 410
Cdd:COG4192  618 QFGGDLYL 625
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 325-426 4.59e-15

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 71.03  E-value: 4.59e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 325 DRTFIHQVMINLVKNAIEA----SIPPIKIALSVH-NQGKVNCITIDDNGQGLANP--DNIFVPFYTTKQQGQGIGLSFC 397
Cdd:cd16944    1 DTTQISQVLTNILKNAAEAiegrPSDVGEVRIRVEaDQDGRIVLIVCDNGKGFPREmrHRATEPYVTTRPKGTGLGLAIV 80

                         90       100
                 ....*....|....*....|....*....
gi 930309252 398 RNVIEQHHGSLSLINKnKTQGVIATVLLP 426
Cdd:cd16944   81 KKIMEEHGGRISLSNR-EAGGACIRIILP 108
glnL PRK11073
nitrogen regulation protein NR(II);
128-406 1.03e-14

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 74.73  E-value: 1.03e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 128 QLIEHFNVPIMVLDQHNKLSYANNA----FSE-----FKQTQWQTLRYTSAEqLGLTKQ----GAHWQFSDVITAQQWQI 194
Cdd:PRK11073  11 QILNSLINSILLLDDDLAIHYANPAaqqlLAQssrklFGTPLPELLSYFSLN-IELMREslqaGQGFTDNEVTLVIDGRS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 195 RHSEFIEQGSCHQLIVM----IDITSALRENQLQAWQQI-----IRVLGHEIRNSLTPVTAMAENLAVKLTEPRQVQALN 265
Cdd:PRK11073  90 HILSLTAQRLPEGMILLemapMDNQRRLSQEQLQHAQQVaardlVRGLAHEIKNPLGGLRGAAQLLSKALPDPALTEYTK 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 266 VISERCNYLNEFVTRYGDINKP---LTLNIVEIdtaafLKQVCAIypdVEFSCVTNAT----------TFKADRTFIHQV 332
Cdd:PRK11073 170 VIIEQADRLRNLVDRLLGPQRPgthVTESIHKV-----AERVVQL---VSLELPDNVRlirdydpslpELAHDPDQIEQV 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 333 MINLVKNAIEASIPP---IKI----ALSVHNQGK----VNCITIDDNGQGLanPDNI----FVPFYTTKQQGQGIGLSFC 397
Cdd:PRK11073 242 LLNIVRNALQALGPEggtITLrtrtAFQLTLHGEryrlAARIDIEDNGPGI--PPHLqdtlFYPMVSGREGGTGLGLSIA 319


                 ....*....
gi 930309252 398 RNVIEQHHG 406
Cdd:PRK11073 320 RNLIDQHSG 328
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 44-426 1.21e-14

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 74.88  E-value: 1.21e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252  44 STVISSLFLAIYLKLFTRTYKKVINSFNRNHAHLDAILNEDYNQLVKPSYQAGSIHKLQQSLIELSEELFKKKSRYDQHV 123
Cdd:COG3290    2 LLLLLLLLLLLILLILILILLLLLLIILLLILLLVLLLLLFLLFVIILLLLLLILLLILLLLLLLLLAALLLKLLEEIAR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 124 FLVYQ--LIEHFNVPIMVLDQHNKLSYANNAFSEFKQTQW--QTLRYTSAEQLGLTKQGAHWQFSDVITAQQWQIRHSEF 199
Cdd:COG3290   82 LVEEReaVLESIREGVIAVDRDGRITLINDAARRLLGLDAigRPIDEVLAEVLETGERDEEILLNGRVLVVNRVPIRDDG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 200 IEQGSchqLIVMIDITS-ALRENQLQAWQQII---RVLGHEIRNSLTPVTAMAENLAVKlteprqvQALNvisercnYLN 275
Cdd:COG3290  162 RVVGA---VATFRDRTElERLEEELEGVKELAealRAQRHDFRNHLHTISGLLQLGEYD-------EALE-------YID 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 276 EFVTRYGDINKPLTLNIVEIDTAAFLKQVCAI----YPDVEFSCVTNATTFKADRTFIHQVMINLVKNAIEAS----IPP 347
Cdd:COG3290  225 EISEELQELIDSLLSRIGNPVLAALLLGKAARarerGIDLTIDIDSDLPDLPLSDTDLVTILGNLLDNAIEAVeklpEEE 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 348 IKIALSVHNQGKVNCITIDDNGQGLAN--PDNIFVPFYTTK-QQGQGIGLSFCRNVIEQHHGSLSlINKNKTQGVIATVL 424
Cdd:COG3290  305 RRVELSIRDDGDELVIEVEDSGPGIPEelLEKIFERGFSTKlGEGRGLGLALVKQIVEKYGGTIE-VESEEGEGTVFTVR 383


                 ..
gi 930309252 425 LP 426
Cdd:COG3290  384 LP 385
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 329-426 4.12e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 68.12  E-value: 4.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 329 IHQVMINLVKNAIEASipPIKIALSVHNQGKVNCITIDDNGQGLANPD--NIFVPFY------TTKQQGQGIGLSFCRNV 400
Cdd:cd16949    1 LARALENVLRNALRYS--PSKILLDISQDGDQWTITITDDGPGVPEDQleQIFLPFYrvdsarDRESGGTGLGLAIAERA 78

                         90       100
                 ....*....|....*....|....*.
gi 930309252 401 IEQHHGSLSLINkNKTQGVIATVLLP 426
Cdd:cd16949   79 IEQHGGKIKASN-RKPGGLRVRIWLP 103
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 289-410 2.57e-13

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 71.35  E-value: 2.57e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 289 TLNIVEIDTAAFLKQVCAI------YPDVEFScVTNATTFKADRTFIHQVMINLVKNAIEASIP--PIKIALSVHNQGKV 360
Cdd:COG4251  350 ELEFEPVDLNELLEEVLEDleprieERGAEIE-VGPLPTVRGDPTLLRQVFQNLISNAIKYSRPgePPRIEIGAEREGGE 428

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 930309252 361 NCITIDDNGQGLANP--DNIFVPFYT----TKQQGQGIGLSFCRNVIEQHHGSLSL 410
Cdd:COG4251  429 WVFSVRDNGIGIDPEyaEKIFEIFQRlhsrDEYEGTGIGLAIVKKIVERHGGRIWV 484
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 329-412 7.45e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 64.40  E-value: 7.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 329 IHQVMINLVKNAIEA----SIPPIKIALSVHNQGKVncITIDDNGQGLA--NPDNIFVPFYTTKQ--QGQGIGLSFCRNV 400
Cdd:cd16976    1 IQQVLMNLLQNALDAmgkvENPRIRIAARRLGGRLV--LVVRDNGPGIAeeHLSRVFDPFFTTKPvgKGTGLGLSISYGI 78

                         90
                 ....*....|..
gi 930309252 401 IEQHHGSLSLIN 412
Cdd:cd16976   79 VEEHGGRLSVAN 90
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 326-426 9.27e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 64.37  E-value: 9.27e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 326 RTFIHQVMINLVKNAIEASIPPIKIALSVHNQGKVNCITIDDNGQGLANPD--NIFVPFYTTKQ--QGQGIGLSFCRNVI 401
Cdd:cd16943    1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEIlgRIFDPFFTTKPvgEGTGLGLSLSYRII 80

                         90       100
                 ....*....|....*....|....*...
gi 930309252 402 EQHHGSL---SLINKnktqGVIATVLLP 426
Cdd:cd16943   81 QKHGGTIrvaSVPGG----GTRFTIILP 104
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 323-427 4.40e-12

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 67.56  E-value: 4.40e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 323 KADRTFIHQVMINLVKNAIEASIPPIKIALSVHNQGKVNCITIDDNGQGLanPD----NIFVPFYT-----TKQQGQGIG 393
Cdd:PRK11100 363 LGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPGI--PDyalpRIFERFYSlprpaNGRKSTGLG 440

                         90       100       110
                 ....*....|....*....|....*....|....
gi 930309252 394 LSFCRNVIEQHHGSLSLINKNKTqGVIATVLLPN 427
Cdd:PRK11100 441 LAFVREVARLHGGEVTLRNRPEG-GVLATLTLPR 473
PRK09303 PRK09303
histidine kinase;
217-406 9.47e-11

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 63.05  E-value: 9.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 217 ALREnQLQAWQQIIRVLGHEIRNSLTpvtamAENLAVKLTEPRQVQALNVISE--RCNYLNEFVTRYGDINK-------- 286
Cdd:PRK09303 143 TLLE-QLKFKDRVLAMLAHDLRTPLT-----AASLALETLELGQIDEDTELKPalIEQLQDQARRQLEEIERlitdllev 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 287 ------PLTLNIVEIDtaafLKQVCA-IYPDVEFSCVTNATTFK-----------ADRTFIHQVMINLVKNAIEASIPPI 348
Cdd:PRK09303 217 grtrweALRFNPQKLD----LGSLCQeVILELEKRWLAKSLEIQtdipsdlpsvyADQERIRQVLLNLLDNAIKYTPEGG 292

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 930309252 349 KIALSV-H--NQgKVNcITIDDNGQG--LANPDNIFVPFYTTKQ----QGQGIGLSFCRNVIEQHHG 406
Cdd:PRK09303 293 TITLSMlHrtTQ-KVQ-VSICDTGPGipEEEQERIFEDRVRLPRdegtEGYGIGLSVCRRIVRVHYG 357
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 335-426 1.70e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 57.68  E-value: 1.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 335 NLVKNAIEAS----IPPIKIALSVHNQGKVNCITIDDNGQGLANP--DNIFVPFYTTKQQG-QGIGLSFCRNVIEQHHGS 407
Cdd:cd16915    7 NLIDNALDALaatgAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPElrDKVFERGVSTKGQGeRGIGLALVRQSVERLGGS 86

                         90
                 ....*....|....*....
gi 930309252 408 LSLINkNKTQGVIATVLLP 426
Cdd:cd16915   87 ITVES-EPGGGTTFSIRIP 104
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
335-426 3.02e-10

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 61.87  E-value: 3.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 335 NLVKNAIEASIPPIKIALSVHNQGKVncITIDDNGQGLANPD--NIFVPFYTTKQQ------GQGIGLSFCRNVIEQHHG 406
Cdd:PRK09470 360 NIVRNALRYSHTKIEVAFSVDKDGLT--ITVDDDGPGVPEEEreQIFRPFYRVDEArdresgGTGLGLAIVENAIQQHRG 437

                         90       100
                 ....*....|....*....|..
gi 930309252 407 SlslINKNKTQ--GVIATVLLP 426
Cdd:PRK09470 438 W---VKAEDSPlgGLRLTIWLP 456
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 331-426 4.12e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 56.81  E-value: 4.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 331 QVMINLVKNAIEASIPP-IKIALSVHNQGKVNCITIDDNGQGL--ANPDNIFVPFYTTKQQGQ------GIGLSFCRNVI 401
Cdd:cd16953    3 QVLRNLIGNAISFSPPDtGRITVSAMPTGKMVTISVEDEGPGIpqEKLESIFDRFYTERPANEafgqhsGLGLSISRQII 82

                         90       100
                 ....*....|....*....|....*...
gi 930309252 402 EQHHGSLSLINKNKTQGVIA---TVLLP 426
Cdd:cd16953   83 EAHGGISVAENHNQPGQVIGarfTVQLP 110
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 331-406 1.53e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 55.10  E-value: 1.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 331 QVMINLVKNAIEAsIPPI--KIALSVHNQGKVNC----------ITIDDNGQGLANP--DNIFVPFYTTKQQGQGIGLSF 396
Cdd:cd16918    3 QVFLNLVRNAAQA-LAGSggEIILRTRTQRQVTLghprhrlalrVSVIDNGPGIPPDlqDTIFYPMVSGRENGTGLGLAI 81

                         90
                 ....*....|
gi 930309252 397 CRNVIEQHHG 406
Cdd:cd16918   82 AQNIVSQHGG 91
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 325-425 3.37e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 54.00  E-value: 3.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 325 DRTFIHQVMINLVKNAIEASIPPIKIALSVHNQGKVNCITIDDNGQGLanPD----NIFVPFYT-----TKQQGQGIGLS 395
Cdd:cd16945    1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGI--PDyalnRVFERFYSlprphSGQKSTGLGLA 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 930309252 396 FCRNVIEQHHGSLSLinKNKTQGVIATVLL 425
Cdd:cd16945   79 FVQEVAQLHGGRITL--RNRPDGVLAFLTL 106
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 325-423 2.03e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 52.08  E-value: 2.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 325 DRTFIHQVMINLVKNAIEASipPIKIALSVHNQGKVNCIT--IDDNGQGLANPD--NIFVPFYT-----TKQQGQGIGLS 395
Cdd:cd16975    1 DTLLLSRALINIISNACQYA--PEGGTVSISIYDEEEYLYfeIWDNGHGFSEQDlkKALELFYRddtsrRSGGHYGMGLY 78

                         90       100
                 ....*....|....*....|....*...
gi 930309252 396 FCRNVIEQHHGSLSLINkNKTQGVIATV 423
Cdd:cd16975   79 IAKNLVEKHGGSLIIEN-SQKGGAEVTV 105
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
329-406 2.77e-08

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 56.22  E-value: 2.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 329 IHQVMINLVKNAIEASIPP--IKIALSVHN-------------QGKVNCITIDDNGQGL--ANPDNIFVPFYTTKQQGQG 391
Cdd:PRK13837 561 LQQVLMNLCSNAAQAMDGAgrVDISLSRAKlrapkvlshgvlpPGRYVLLRVSDTGAGIdeAVLPHIFEPFFTTRAGGTG 640

                         90
                 ....*....|....*
gi 930309252 392 IGLSFCRNVIEQHHG 406
Cdd:PRK13837 641 LGLATVHGIVSAHAG 655
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 331-410 5.12e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 50.95  E-value: 5.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 331 QVMINLVKNAI----EASIpPIKIAL-SVHNQGKVNCITIDDNGQGLaNPD---NIFVPF------YTTKQQGQGIGLSF 396
Cdd:cd16922    3 QILLNLLGNAIkfteEGEV-TLRVSLeEEEEDGVQLRFSVEDTGIGI-PEEqqaRLFEPFsqadssTTRKYGGTGLGLAI 80

                         90
                 ....*....|....
gi 930309252 397 CRNVIEQHHGSLSL 410
Cdd:cd16922   81 SKKLVELMGGDISV 94
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 329-426 2.58e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 48.60  E-value: 2.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 329 IHQVMINLVKNAIEASippiKIALSVHNQGKVN--CITIDDNGQGLANP--DNIFVPFYTTKQ----QGQGIGLSFCRNV 400
Cdd:cd16950    1 LKRVLSNLVDNALRYG----GGWVEVSSDGEGNrtRIQVLDNGPGIAPEevDELFQPFYRGDNargtSGTGLGLAIVQRI 76

                         90       100
                 ....*....|....*....|....*.
gi 930309252 401 IEQHHGSLSLINKNKTqGVIATVLLP 426
Cdd:cd16950   77 SDAHGGSLTLANRAGG-GLCARIELP 101
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 307-410 9.64e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 48.01  E-value: 9.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 307 IYPDVEFSCVTN---ATTFKADRTFIHQVMINLVKNAIEASIPPIKIALSVhNQGKVNcITIDDNGQGLAnPDNIFVPF- 382
Cdd:cd16954   13 VYQRKGVSISLDispELRFPGERNDLMELLGNLLDNACKWCLEFVEVTARQ-TDGGLH-LIVDDDGPGVP-ESQRSKIFq 89

                         90       100       110
                 ....*....|....*....|....*....|..
gi 930309252 383 ----YTTKQQGQGIGLSFCRNVIEQHHGSLSL 410
Cdd:cd16954   90 rgqrLDEQRPGQGLGLAIAKEIVEQYGGELSL 121
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 325-409 3.29e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 45.53  E-value: 3.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 325 DRTFIHQVMINLVKNAIEASIPPIKIALSVHNQGKVNCITIDDNGQGLaNPDN---IFVPFYTTKQQ------GQGIGLS 395
Cdd:cd16946    1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGV-SDDQlarLFERFYRVESSrnrasgGSGLGLA 79

                         90
                 ....*....|....
gi 930309252 396 FCRNVIEQHHGSLS 409
Cdd:cd16946   80 ICHNIALAHGGTIS 93
PRK10490 PRK10490
sensor protein KdpD; Provisional
 325-426 4.84e-06

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 48.88  E-value: 4.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 325 DRTFIHQVMINLVKNAIEASIPPIKIALSVHNQGKVNCITIDDNGQGLANPDN--IFVPFYTTKQQ----GQGIGLSFCR 398
Cdd:PRK10490 775 DGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEqlIFDKFARGNKEsaipGVGLGLAICR 854

                         90       100
                 ....*....|....*....|....*...
gi 930309252 399 NVIEQHHGSLSLINkNKTQGVIATVLLP 426
Cdd:PRK10490 855 AIVEVHGGTIWAEN-RPEGGACFRVTLP 881
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 329-410 5.28e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 45.01  E-value: 5.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 329 IHQVMINLVKNAIEASIP--PIKIALSVHNQGKVNCITIDDNGQGLaNPD---NIFVPFYTTKQQ----GQGIGLSFCRN 399
Cdd:cd16921    1 LGQVLTNLLGNAIKFRRPrrPPRIEVGAEDVGEEWTFYVRDNGIGI-DPEyaeKVFGIFQRLHSReeyeGTGVGLAIVRK 79

                         90
                 ....*....|.
gi 930309252 400 VIEQHHGSLSL 410
Cdd:cd16921   80 IIERHGGRIWL 90
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
221-426 5.34e-06

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 48.96  E-value: 5.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252  221 NQLQAWQQIIRVLGHEIRNSLTPVTAMAENLA-VKLTEPRQVQALNVISERCNYLNEFVTRYGDINK----PLTLNIVEI 295
Cdd:PRK09959  707 NATVAKSQFLATMSHEIRTPISSIMGFLELLSgSGLSKEQRVEAISLAYATGQSLLGLIGEILDVDKiesgNYQLQPQWV 786

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252  296 DTAAFLKQVC------AIYPDVEFSCvtnATTF------KADRTFIHQVMINLVKNAIEASIP-PIKIALS---VHNQGK 359
Cdd:PRK09959  787 DIPTLVQNTChsfgaiAASKSIALSC---SSTFpdhylvKIDPQAFKQVLSNLLSNALKFTTEgAVKITTSlghIDDNHA 863

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 930309252  360 VNCITIDDNGQGLANPDN--IFVPFYTT----KQQGQGIGLSFCRNVIEQHHGSLSLiNKNKTQGVIATVLLP 426
Cdd:PRK09959  864 VIKMTIMDSGSGLSQEEQqqLFKRYSQTsagrQQTGSGLGLMICKELIKNMQGDLSL-ESHPGIGTTFTITIP 935
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 331-410 7.04e-06

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 45.06  E-value: 7.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 331 QVMINLVKNAIEASIPPIKIALSVHNQ---------------GKVNCITIDDNGQGLANP--DNIFVPFYTTKQ--QGQG 391
Cdd:cd16919    3 LAILNLAVNARDAMPEGGRLTIETSNQrvdadyalnyrdlipGNYVCLEVSDTGSGMPAEvlRRAFEPFFTTKEvgKGTG 82

                         90
                 ....*....|....*....
gi 930309252 392 IGLSFCRNVIEQHHGSLSL 410
Cdd:cd16919   83 LGLSMVYGFVKQSGGHLRI 101
envZ PRK09467
osmolarity sensor protein; Provisional
 329-426 8.43e-06

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 47.60  E-value: 8.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 329 IHQVMINLVKNAIEASIPPIKIalSVHNQGKVNCITIDDNGQGLANPD--NIFVPFyttKQ-------QGQGIGLSFCRN 399
Cdd:PRK09467 332 IKRALANLVVNAARYGNGWIKV--SSGTEGKRAWFQVEDDGPGIPPEQlkHLFQPF---TRgdsargsSGTGLGLAIVKR 406

                         90       100
                 ....*....|....*....|....*..
gi 930309252 400 VIEQHHGSLSLINKNKtQGVIATVLLP 426
Cdd:PRK09467 407 IVDQHNGKVELGNSEE-GGLSARAWLP 432
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 332-426 9.01e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 44.30  E-value: 9.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 332 VMINLVKNAIEASIPPIKIALSVHNQGKVNCITIDDNGQGLAN--PDNIFVPFY----TTKQQGQGIGLSFCRNVIEQHH 405
Cdd:cd16923    4 VFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDfkLEKLFERFYrgdnSRNTEGAGLGLSIAKAIIELHG 83

                         90       100
                 ....*....|....*....|.
gi 930309252 406 GSLSLINKNKtqGVIATVLLP 426
Cdd:cd16923   84 GSASAEYDDN--HDLFKVRLP 102
PRK15347 PRK15347
two component system sensor kinase;
284-410 1.58e-05

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 47.33  E-value: 1.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 284 INKPLTLNiveidtaaflkqvCAIYPDVefscvtnATTFKADRTFIHQVMINLVKNAIEASiPPIKIALSVHNQGKVNCI 363
Cdd:PRK15347 489 QSKSLTLR-------------TFVGAHV-------PLYLHLDSLRLRQILVNLLGNAVKFT-ETGGIRLRVKRHEQQLCF 547

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 930309252 364 TIDDNGQGLANPD--NIFVPFYTT--KQQGQGIGLSFCRNVIEQHHGSLSL 410
Cdd:PRK15347 548 TVEDTGCGIDIQQqqQIFTPFYQAdtHSQGTGLGLTIASSLAKMMGGELTL 598
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 325-423 1.58e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 43.93  E-value: 1.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 325 DRTFIHQVMINLVKNAI----EASIPPIKIALSVHNQgkvncITIDDNGQGLANPD--NIFVPFY---TTKQQGQGIGLS 395
Cdd:cd16940   10 DALLLFLLLRNLVDNAVryspQGSRVEIKLSADDGAV-----IRVEDNGPGIDEEEleALFERFYrsdGQNYGGSGLGLS 84

                         90       100
                 ....*....|....*....|....*...
gi 930309252 396 FCRNVIEQHHGSLSLINkNKTQGVIATV 423
Cdd:cd16940   85 IVKRIVELHGGQIFLGN-AQGGGLEAWV 111
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 329-410 2.61e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 42.80  E-value: 2.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 329 IHQVMINLVKNAIEASIPPIKIALSVhnQGKVNCITIDDNGQGLAnPDN---IFVPF------YTTKQQGQGIGLSFCRN 399
Cdd:cd16939    1 MARALDNLLRNALRYAHRTVRIALLV--SGGRLTLIVEDDGPGIP-AAArerVFEPFvrldpsRDRATGGFGLGLAIVHR 77

                         90
                 ....*....|.
gi 930309252 400 VIEQHHGSLSL 410
Cdd:cd16939   78 VALWHGGHVEC 88
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 335-409 5.95e-05

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 45.29  E-value: 5.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 335 NLVKNAIEA--SIPPIKIALSVHNQ-GKVNCiTIDDNGQGLA--NPDNIFVPFYTTKQQGQGIGLSFCRNVIEQHHGSLS 409
Cdd:PRK11086 440 NLIENALEAvgGEEGGEISVSLHYRnGWLHC-EVSDDGPGIApdEIDAIFDKGYSTKGSNRGVGLYLVKQSVENLGGSIA 518
HATPase_c_5 pfam14501
GHKL domain; This family represents the structurally related ATPase domains of histidine ...
 332-425 7.25e-05

GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433996 [Multi-domain]  Cd Length: 102  Bit Score: 41.43  E-value: 7.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252  332 VMINLVKNAIEASI----PPIkIALSVHNQGKVNCITIDdngqglaNPDNIFVP----FYTTKQQGQ--GIGLSFCRNVI 401
Cdd:pfam14501   9 IFGNLLDNAIEACSkiddNRF-IRLKIREKQNFLIIRIE-------NTYEGELKfegkLPSTKTKGDghGIGLKSIRRIV 80

                          90       100
                  ....*....|....*....|....
gi 930309252  402 EQHHGSLSLINKNKTqgVIATVLL 425
Cdd:pfam14501  81 KKYGGNLSTEIENGI--FTLSILL 102
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 189-410 1.06e-04

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 44.51  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 189 AQQWQIRHSEFieqgscHQLIVMIDITSALRENQLQAWQQIIRVLGHEIRNSLTPVTAMAENLAVKLTEPRQ---VQALN 265
Cdd:PRK11466 413 AAQVKARTAEL------QELVIEHRQARAEAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQrddLRAIT 486

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 266 VISERC-NYLNEfVTRYGDIN---------------KPL---TLNIVEIDTAAFLKQVCAIYPDVEfscvtnATTFKADR 326
Cdd:PRK11466 487 DSGESLlTILND-ILDYSAIEaggknvsvsdepfepRPLlesTLQLMSGRVKGRPIRLATDIADDL------PTALMGDP 559

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 327 TFIHQVMINLVKNAIEASIPPIkIALSVHNQGKVNCITIDDNGQGL--ANPDNIFVPFY--TTKQQGQGIGLSFCRNVIE 402
Cdd:PRK11466 560 RRIRQVITNLLSNALRFTDEGS-IVLRSRTDGEQWLVEVEDSGCGIdpAKLAEIFQPFVqvSGKRGGTGLGLTISSRLAQ 638


                 ....*...
gi 930309252 403 QHHGSLSL 410
Cdd:PRK11466 639 AMGGELSA 646
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 293-411 1.19e-04

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 42.33  E-value: 1.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 293 VEIDTAAFLKQVCAIY----PDVEFSCvTNATTFKADRTFIHQVMINLVKNAIEASI----------PPIKIALsVHNQG 358
Cdd:cd16929    5 VVEDASEEARVLCDDYylssPELEIEG-DPSIRFPYVPSHLYYILFELLKNAMRATVeshgddsddlPPIKVTV-AKGDE 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 930309252 359 KVnCITIDDNGQGLA--NPDNIFVPFYTTKQQ-------------------GQGIGLSFCRNVIEQHHGSLSLI 411
Cdd:cd16929   83 DL-TIKISDRGGGIPreDLARLFSYMYSTAPQpslddfsdlisgtqpsplaGFGYGLPMSRLYAEYFGGDLDLQ 155
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
294-426 1.33e-04

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 43.80  E-value: 1.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 294 EIDTAAFLKQVCAIYPDVEfscvtNATTFKADRTFIHQVMINLVKNAIEASiPP---IKIALSVHNQGKVncITIDDNGQ 370
Cdd:PRK10755 218 ELSEMLEQRQQTLLLPESA-----ADITVQGDATLLRLLLRNLVENAHRYS-PEgstITIKLSQEDGGAV--LAVEDEGP 289

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 371 GL--ANPDNIFVPFYTTKQQ--GQGIGLSFCRNVIEQHHGSLSLINKNKTQGVIATVLLP 426
Cdd:PRK10755 290 GIdeSKCGELSKAFVRMDSRygGIGLGLSIVSRITQLHHGQFFLQNRQERSGTRAWVWLP 349
HATPase_CheA-like cd16916
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...
 325-426 1.91e-04

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.


Pssm-ID: 340393 [Multi-domain]  Cd Length: 178  Bit Score: 41.80  E-value: 1.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 325 DRTFIHQV---MINLVKNAIEASI-----------PPI-KIALSVHNQGKVNCITIDDNGQG--------------LANP 375
Cdd:cd16916   32 DKSVLEKLadpLTHLLRNAVDHGIeapeerlaagkPPEgTITLRAEHQGNQVVIEVSDDGRGidrekirekaiergLITA 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 930309252 376 DN------------IFVPFYTTKQQ-----GQGIGLSFCRNVIEQHHGSLSlINKNKTQGVIATVLLP 426
Cdd:cd16916  112 DEaatlsddevlnlIFAPGFSTAEQvtdvsGRGVGMDVVKRSIESLGGTIE-VESEPGQGTTFTIRLP 178
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
291-426 2.55e-04

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 43.08  E-value: 2.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 291 NIVEIDTAAFLKQVCAIYPDVEFSCVTNATTFkADRTFIHQVMINLVKNAIEASIPPIKIALSVHNQGKVNCITIDDNGQ 370
Cdd:PRK10549 316 PLLEVAGGAFRERFASRGLTLQLSLPDSATVF-GDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAP 394

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 930309252 371 GLANP--DNIFVPFYTTKQQ------GQGIGLSFCRNVIEQHHGSLSlINKNKTQGVIATVLLP 426
Cdd:PRK10549 395 GVSDEqlQKLFERFYRTEGSrnrasgGSGLGLAICLNIVEAHNGRII-AAHSPFGGVSITVELP 457
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 329-426 1.67e-03

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 37.86  E-value: 1.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 329 IHQVMINLVKNAIEASipP----IKIALSVHNQGKVnCITIDDNGQGLanPDN----IFVPFY------TTKQQGQGIGL 394
Cdd:cd16925    5 YERVVLNLLSNAFKFT--PdggrIRCILEKFRLNRF-LLTVSDSGPGI--PPNlreeIFERFRqgdgssTRAHGGTGLGL 79

                         90       100       110
                 ....*....|....*....|....*....|..
gi 930309252 395 SFCRNVIEQHHGSLSlINKNKTQGVIATVLLP 426
Cdd:cd16925   80 SIVKEFVELHGGTVT-VSDAPGGGALFQVELP 110
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 225-276 2.58e-03

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 36.04  E-value: 2.58e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 930309252  225 AWQQIIRVLGHEIRNSLTPVTAMAENLAVKLTEPRQVQALNVISERCNYLNE 276
Cdd:pfam00512   1 AKSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLR 52
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
336-426 2.64e-03

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 40.00  E-value: 2.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 336 LVKNAIEASI----PPIKIALSVHNQGKVNCITIDDNGQGLANPD--NIFVPFyTTKQQGQGIGLsfcRNV---IEQHHG 406
Cdd:COG2972  344 LVENAIEHGIepkeGGGTIRISIRKEGDRLVITVEDNGVGMPEEKleKLLEEL-SSKGEGRGIGL---RNVrerLKLYYG 419

                         90       100
                 ....*....|....*....|..
gi 930309252 407 SLSL--INKNKTQGVIATVLLP 426
Cdd:COG2972  420 EEYGleIESEPGEGTTVTIRIP 441
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 324-413 3.57e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 37.49  E-value: 3.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 324 ADRTFIHQVMINLVKNAIEASIPPIKIALSVHNQGKVNCITIDDNGQGLANP--DNIFVPFYTTKQ------QGQGIGLS 395
Cdd:cd16947   16 ANTEALQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETekDHVFERLYTLEDsrnsakQGNGLGLT 95

                         90
                 ....*....|....*...
gi 930309252 396 FCRNVIEQHHGSLSLINK 413
Cdd:cd16947   96 ITKRLAESMGGSIYVNSK 113
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
331-409 6.81e-03

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 38.46  E-value: 6.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 930309252 331 QVMINLVKNAIEASIPPIKIalSVHNQGKVNCITIDDNGQGLanPDN----IFV--PFYTTKQQGQGIGLSFCRNVIEQH 404
Cdd:PRK10815 381 EVMGNVLDNACKYCLEFVEI--SARQTDEHLHIVVEDDGPGI--PESkrelIFDrgQRADTLRPGQGLGLSVAREITEQY 456


                 ....*
gi 930309252 405 HGSLS 409
Cdd:PRK10815 457 EGKIS 461
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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