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Conserved domains on  [gi|938307548|gb|KPQ40861|]
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ribosomal RNA small subunit methyltransferase A [Phormidium sp. OSCR]

Protein Classification

ribosomal RNA small subunit methyltransferase A( domain architecture ID 10000482)

ribosomal RNA small subunit methyltransferase A specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle

CATH:  2.20.25.110
EC:  2.1.1.-|2.1.1.182
Gene Ontology:  GO:1904047|GO:0052908|GO:0031167
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 3-269 1.75e-118

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


:

Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 339.79  E-value: 1.75e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548   3 PRKRFAQHWLRSDAVLDKIVAAAQLSPRDRVLEIGPGQGVLTRRLFPLAESLLAVELDRDLCQKLAKKFGTIDNFLLLQD 82
Cdd:COG0030   11 PKKRLGQNFLIDPNIIRRIVDAAGITPGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETFAAYPNLTVIEG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548  83 DFLSLDVSKTLAQSPaifqnqNKVVANIPYNITAPILEKLLGdvdapNPNPYESIVLLVQKEVGDRLCAKPGSKTFGALS 162
Cdd:COG0030   91 DALKVDLPALAAGEP------LKVVGNLPYNISTPILFKLLE-----ARPPIEDAVLMVQKEVAERLVAKPGSKDYGRLS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548 163 VRVQYLAECESICHVPPKAFYPPPKVDSVVVRLTPRPIP-VPAENPKKMATLIKLGFSSRRKMLRNNLKGQVDSDQLQNL 241
Cdd:COG0030  160 VLVQYYADVEILFTVPPEAFYPPPKVDSAVVRLTPRPEPlVPVADEKLFFRVVKAAFSQRRKTLRNSLKSLFSKERLEEA 239

                        250       260
                 ....*....|....*....|....*...
gi 938307548 242 LEQRNLPPESRAERLSVEDWVALANGLS 269
Cdd:COG0030  240 LEAAGIDPTARAEELSVEEFARLANALK 267
 
Name Accession Description Interval E-value
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 3-269 1.75e-118

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 339.79  E-value: 1.75e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548   3 PRKRFAQHWLRSDAVLDKIVAAAQLSPRDRVLEIGPGQGVLTRRLFPLAESLLAVELDRDLCQKLAKKFGTIDNFLLLQD 82
Cdd:COG0030   11 PKKRLGQNFLIDPNIIRRIVDAAGITPGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETFAAYPNLTVIEG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548  83 DFLSLDVSKTLAQSPaifqnqNKVVANIPYNITAPILEKLLGdvdapNPNPYESIVLLVQKEVGDRLCAKPGSKTFGALS 162
Cdd:COG0030   91 DALKVDLPALAAGEP------LKVVGNLPYNISTPILFKLLE-----ARPPIEDAVLMVQKEVAERLVAKPGSKDYGRLS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548 163 VRVQYLAECESICHVPPKAFYPPPKVDSVVVRLTPRPIP-VPAENPKKMATLIKLGFSSRRKMLRNNLKGQVDSDQLQNL 241
Cdd:COG0030  160 VLVQYYADVEILFTVPPEAFYPPPKVDSAVVRLTPRPEPlVPVADEKLFFRVVKAAFSQRRKTLRNSLKSLFSKERLEEA 239

                        250       260
                 ....*....|....*....|....*...
gi 938307548 242 LEQRNLPPESRAERLSVEDWVALANGLS 269
Cdd:COG0030  240 LEAAGIDPTARAEELSVEEFARLANALK 267
ksgA TIGR00755
ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, ...
 3-268 8.56e-90

ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, this protein is responsible for the dimethylation of two adjacent adenosine residues in a conserved hairpin of 16S rRNA in bacteria, 18S rRNA in eukaryotes. This adjacent dimethylation is the only rRNA modification shared by bacteria and eukaryotes. A single member of this family is present in each of the first 20 completed microbial genomes. This protein is essential in yeast, but not in E. coli, where its deletion leads to resistance to the antibiotic kasugamycin. Alternate name: S-adenosylmethionine--6-N',N'-adenosyl (rRNA) dimethyltransferase [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273252 [Multi-domain]  Cd Length: 254  Bit Score: 266.79  E-value: 8.56e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548    3 PRKRFAQHWLRSDAVLDKIVAAAQLSPRDRVLEIGPGQGVLTRRLFPLAESLLAVELDRDLCQKLAKKFGTIDNFLLLQD 82
Cdd:TIGR00755   3 PRKSLGQNFLVDENVIRKIVEAANIQEGDRVLEIGPGLGALTEPLLKRAKKVTAIEIDPRLAERLRKLLSLYNNLEIIEG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548   83 DFLSLDVsktlaqsPAIFQNQNKVVANIPYNITAPILEKLLGDVDAPnpnpyESIVLLVQKEVGDRLCAKPGSKTFGALS 162
Cdd:TIGR00755  83 DALKFDL-------NELAKDLTKVVGNLPYNISSPLIFKLLKEKDAF-----KLAVLMVQKEVAERLVAKPGSKDYGRLS 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548  163 VRVQYLAECESICHVPPKAFYPPPKVDSVVVRLTPRPIPVPAENPKKMATLIKLGFSSRRKMLRNNLKGQVDSdqLQNLL 242
Cdd:TIGR00755 151 VLVQYYANVEIVFKVPPSAFYPPPKVDSAVVRLVPLKRKPSPKDFALFEELLKAAFQQRRKTLRNNLKNLLSE--LVELL 228

                         250       260
                  ....*....|....*....|....*.
gi 938307548  243 EQRNLPPESRAERLSVEDWVALANGL 268
Cdd:TIGR00755 229 EELGIDPDKRVEQLSPEDFLRLANLL 254
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
1-271 2.41e-72

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 222.47  E-value: 2.41e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548   1 MPPRKRFAQHWLRSDAVLDKIVAAAQLSPRDRVLEIGPGQGVLTRRLFPLAESLLAVELDRDLCQKLAKKFGTIDNFLLL 80
Cdd:PRK14896   1 IRMNKKLGQHFLIDDRVVDRIVEYAEDTDGDPVLEIGPGKGALTDELAKRAKKVYAIELDPRLAEFLRDDEIAAGNVEII 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548  81 QDDFLSLDVSKTlaqspaifqnqNKVVANIPYNITAPILEKLLgdvdapnPNPYESIVLLVQKEVGDRLCAKPGSKTFGA 160
Cdd:PRK14896  81 EGDALKVDLPEF-----------NKVVSNLPYQISSPITFKLL-------KHGFEPAVLMYQKEFAERMVAKPGTKEYGR 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548 161 LSVRVQYLAECESICHVPPKAFYPPPKVDSVVVRLTPRPIPVPAENPKKMATLIKLGFSSRRKMLRNNLKGQVDSDQLQN 240
Cdd:PRK14896 143 LSVMVQYYADVEIVEKVPPGAFSPKPKVDSAVVRLTPREPKYEVYDEDFFDDFVKALFQHRRKTLRNALKNSAHISGKED 222

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 938307548 241 LLEQRNLPPE----SRAERLSVEDWVALANGLSLN 271
Cdd:PRK14896 223 IKAVVEALPEellnKRVFQLSPEEIAELANLLYEV 257
rADc smart00650
Ribosomal RNA adenine dimethylases;
17-199 3.29e-65

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 201.20  E-value: 3.29e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548    17 VLDKIVAAAQLSPRDRVLEIGPGQGVLTRRLFPLAESLLAVELDRDLCQKLAKKFGTIDNFLLLQDDFLSLDVSKTlaqs 96
Cdd:smart00650   1 VIDKIVRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLREKFAAADNLTVIHGDALKFDLPKL---- 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548    97 paifqNQNKVVANIPYNITAPILEKLLgdvdaPNPNPYESIVLLVQKEVGDRLCAKPGSKTFGALSVRVQYLAECESICH 176
Cdd:smart00650  77 -----QPYKVVGNLPYNISTPILFKLL-----EEPPAFRDAVLMVQKEVARRLAAKPGSKDYGRLSVLLQPYADVKILFK 146

                          170       180
                   ....*....|....*....|...
gi 938307548   177 VPPKAFYPPPKVDSVVVRLTPRP 199
Cdd:smart00650 147 VPPSAFRPPPKVDSAVVRLERRP 169
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
4-266 1.36e-54

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 177.17  E-value: 1.36e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548    4 RKRFAQHWLRSDAVLDKIVAAAQLSPRDRVLEIGPGQGVLTRRLFPLAESLLAVELDRDLCQKLAKKFGTIDNFLLLQDD 83
Cdd:pfam00398   5 RTSYGQNFLKDPKVINEIVDKANLRESDTVLEIGPGKGALTVILAKRAKQVVAIEIDPRLAKLLQKKLSLDENLTVIHQD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548   84 FLSLDVSKTLAQSPAIFqnqnKVVANIPYNITAPILEKLLgdvDAPNPnPYESIVLLVQKEVGDRLCAKPGSKTFGALSV 163
Cdd:pfam00398  85 FLKFEFPSLVTHIHQEF----LVVGNLPYNISTPIVKQLL---FESRF-GIVDMLLMLQKEFARRLLARPGSKLYSRLSV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548  164 RVQYLAECESICHVPPKAFYPPPKVDSVVVRLTPR-PIPVPAENPKKMATLIKLGFSSRRKMLRNNLKGQVDSDQLQNLL 242
Cdd:pfam00398 157 LRQAFTDVKLVAKVPPSIFSPPPKVDSALVRLERHdPDPHPVKDLDVYDSVVRKLFNRKRKTLSTSLKSLFPGGQLQAFS 236

                         250       260
                  ....*....|....*....|....
gi 938307548  243 EQRNLPPeSRAERLSVEDWVALAN 266
Cdd:pfam00398 237 SHGINDN-ALVKKLSPEQTLDIFN 259
 
Name Accession Description Interval E-value
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 3-269 1.75e-118

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 339.79  E-value: 1.75e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548   3 PRKRFAQHWLRSDAVLDKIVAAAQLSPRDRVLEIGPGQGVLTRRLFPLAESLLAVELDRDLCQKLAKKFGTIDNFLLLQD 82
Cdd:COG0030   11 PKKRLGQNFLIDPNIIRRIVDAAGITPGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRETFAAYPNLTVIEG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548  83 DFLSLDVSKTLAQSPaifqnqNKVVANIPYNITAPILEKLLGdvdapNPNPYESIVLLVQKEVGDRLCAKPGSKTFGALS 162
Cdd:COG0030   91 DALKVDLPALAAGEP------LKVVGNLPYNISTPILFKLLE-----ARPPIEDAVLMVQKEVAERLVAKPGSKDYGRLS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548 163 VRVQYLAECESICHVPPKAFYPPPKVDSVVVRLTPRPIP-VPAENPKKMATLIKLGFSSRRKMLRNNLKGQVDSDQLQNL 241
Cdd:COG0030  160 VLVQYYADVEILFTVPPEAFYPPPKVDSAVVRLTPRPEPlVPVADEKLFFRVVKAAFSQRRKTLRNSLKSLFSKERLEEA 239

                        250       260
                 ....*....|....*....|....*...
gi 938307548 242 LEQRNLPPESRAERLSVEDWVALANGLS 269
Cdd:COG0030  240 LEAAGIDPTARAEELSVEEFARLANALK 267
ksgA TIGR00755
ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, ...
 3-268 8.56e-90

ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, this protein is responsible for the dimethylation of two adjacent adenosine residues in a conserved hairpin of 16S rRNA in bacteria, 18S rRNA in eukaryotes. This adjacent dimethylation is the only rRNA modification shared by bacteria and eukaryotes. A single member of this family is present in each of the first 20 completed microbial genomes. This protein is essential in yeast, but not in E. coli, where its deletion leads to resistance to the antibiotic kasugamycin. Alternate name: S-adenosylmethionine--6-N',N'-adenosyl (rRNA) dimethyltransferase [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273252 [Multi-domain]  Cd Length: 254  Bit Score: 266.79  E-value: 8.56e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548    3 PRKRFAQHWLRSDAVLDKIVAAAQLSPRDRVLEIGPGQGVLTRRLFPLAESLLAVELDRDLCQKLAKKFGTIDNFLLLQD 82
Cdd:TIGR00755   3 PRKSLGQNFLVDENVIRKIVEAANIQEGDRVLEIGPGLGALTEPLLKRAKKVTAIEIDPRLAERLRKLLSLYNNLEIIEG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548   83 DFLSLDVsktlaqsPAIFQNQNKVVANIPYNITAPILEKLLGDVDAPnpnpyESIVLLVQKEVGDRLCAKPGSKTFGALS 162
Cdd:TIGR00755  83 DALKFDL-------NELAKDLTKVVGNLPYNISSPLIFKLLKEKDAF-----KLAVLMVQKEVAERLVAKPGSKDYGRLS 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548  163 VRVQYLAECESICHVPPKAFYPPPKVDSVVVRLTPRPIPVPAENPKKMATLIKLGFSSRRKMLRNNLKGQVDSdqLQNLL 242
Cdd:TIGR00755 151 VLVQYYANVEIVFKVPPSAFYPPPKVDSAVVRLVPLKRKPSPKDFALFEELLKAAFQQRRKTLRNNLKNLLSE--LVELL 228

                         250       260
                  ....*....|....*....|....*.
gi 938307548  243 EQRNLPPESRAERLSVEDWVALANGL 268
Cdd:TIGR00755 229 EELGIDPDKRVEQLSPEDFLRLANLL 254
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
1-271 2.41e-72

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 222.47  E-value: 2.41e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548   1 MPPRKRFAQHWLRSDAVLDKIVAAAQLSPRDRVLEIGPGQGVLTRRLFPLAESLLAVELDRDLCQKLAKKFGTIDNFLLL 80
Cdd:PRK14896   1 IRMNKKLGQHFLIDDRVVDRIVEYAEDTDGDPVLEIGPGKGALTDELAKRAKKVYAIELDPRLAEFLRDDEIAAGNVEII 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548  81 QDDFLSLDVSKTlaqspaifqnqNKVVANIPYNITAPILEKLLgdvdapnPNPYESIVLLVQKEVGDRLCAKPGSKTFGA 160
Cdd:PRK14896  81 EGDALKVDLPEF-----------NKVVSNLPYQISSPITFKLL-------KHGFEPAVLMYQKEFAERMVAKPGTKEYGR 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548 161 LSVRVQYLAECESICHVPPKAFYPPPKVDSVVVRLTPRPIPVPAENPKKMATLIKLGFSSRRKMLRNNLKGQVDSDQLQN 240
Cdd:PRK14896 143 LSVMVQYYADVEIVEKVPPGAFSPKPKVDSAVVRLTPREPKYEVYDEDFFDDFVKALFQHRRKTLRNALKNSAHISGKED 222

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 938307548 241 LLEQRNLPPE----SRAERLSVEDWVALANGLSLN 271
Cdd:PRK14896 223 IKAVVEALPEellnKRVFQLSPEEIAELANLLYEV 257
rADc smart00650
Ribosomal RNA adenine dimethylases;
17-199 3.29e-65

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 201.20  E-value: 3.29e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548    17 VLDKIVAAAQLSPRDRVLEIGPGQGVLTRRLFPLAESLLAVELDRDLCQKLAKKFGTIDNFLLLQDDFLSLDVSKTlaqs 96
Cdd:smart00650   1 VIDKIVRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLREKFAAADNLTVIHGDALKFDLPKL---- 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548    97 paifqNQNKVVANIPYNITAPILEKLLgdvdaPNPNPYESIVLLVQKEVGDRLCAKPGSKTFGALSVRVQYLAECESICH 176
Cdd:smart00650  77 -----QPYKVVGNLPYNISTPILFKLL-----EEPPAFRDAVLMVQKEVARRLAAKPGSKDYGRLSVLLQPYADVKILFK 146

                          170       180
                   ....*....|....*....|...
gi 938307548   177 VPPKAFYPPPKVDSVVVRLTPRP 199
Cdd:smart00650 147 VPPSAFRPPPKVDSAVVRLERRP 169
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
4-266 1.36e-54

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 177.17  E-value: 1.36e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548    4 RKRFAQHWLRSDAVLDKIVAAAQLSPRDRVLEIGPGQGVLTRRLFPLAESLLAVELDRDLCQKLAKKFGTIDNFLLLQDD 83
Cdd:pfam00398   5 RTSYGQNFLKDPKVINEIVDKANLRESDTVLEIGPGKGALTVILAKRAKQVVAIEIDPRLAKLLQKKLSLDENLTVIHQD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548   84 FLSLDVSKTLAQSPAIFqnqnKVVANIPYNITAPILEKLLgdvDAPNPnPYESIVLLVQKEVGDRLCAKPGSKTFGALSV 163
Cdd:pfam00398  85 FLKFEFPSLVTHIHQEF----LVVGNLPYNISTPIVKQLL---FESRF-GIVDMLLMLQKEFARRLLARPGSKLYSRLSV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548  164 RVQYLAECESICHVPPKAFYPPPKVDSVVVRLTPR-PIPVPAENPKKMATLIKLGFSSRRKMLRNNLKGQVDSDQLQNLL 242
Cdd:pfam00398 157 LRQAFTDVKLVAKVPPSIFSPPPKVDSALVRLERHdPDPHPVKDLDVYDSVVRKLFNRKRKTLSTSLKSLFPGGQLQAFS 236

                         250       260
                  ....*....|....*....|....
gi 938307548  243 EQRNLPPeSRAERLSVEDWVALAN 266
Cdd:pfam00398 237 SHGINDN-ALVKKLSPEQTLDIFN 259
PTZ00338 PTZ00338
dimethyladenosine transferase-like protein; Provisional
 1-232 4.47e-52

dimethyladenosine transferase-like protein; Provisional


Pssm-ID: 240367 [Multi-domain]  Cd Length: 294  Bit Score: 171.72  E-value: 4.47e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548   1 MPPRKRFAQHWLRSDAVLDKIVAAAQLSPRDRVLEIGPGQGVLTRRLFPLAESLLAVELDRDLCQKLAKKF---GTIDNF 77
Cdd:PTZ00338   8 MVFNKKFGQHILKNPLVLDKIVEKAAIKPTDTVLEIGPGTGNLTEKLLQLAKKVIAIEIDPRMVAELKKRFqnsPLASKL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548  78 LLLQDDFLSLDVSKtlaqspaiFqnqNKVVANIPYNITAPILEKLLgdvdAPNPnPYESIVLLVQKEVGDRLCAKPGSKT 157
Cdd:PTZ00338  88 EVIEGDALKTEFPY--------F---DVCVANVPYQISSPLVFKLL----AHRP-LFRCAVLMFQKEFALRLLAQPGDEL 151

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 938307548 158 FGALSVRVQYLAECESICHVPPKAFYPPPKVDSVVVRLTPRPIPVPAeNPKKMATLIKLGFSSRRKMLRNNLKGQ 232
Cdd:PTZ00338 152 YCRLSVNTQLLCRVTHLMKVSKNSFNPPPKVESSVVRIEPKNPPPDV-DFEEWDGLLRICFSRKNKTLSAIFKTK 225
COG3963 COG3963
Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];
1-95 2.77e-07

Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];


Pssm-ID: 443163  Cd Length: 193  Bit Score: 49.82  E-value: 2.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938307548   1 MPPRKRFAQHWLR-----------SDAVLDKIVAAAQLSPRDRVLEIGPGQGVLTR----RLFPlAESLLAVELDRDLCQ 65
Cdd:COG3963    6 LSDELLFLREFLRnprtvgaiapsSRALARAMASEVDWSGAGPVVELGPGTGVFTRailaRGVP-DARLLAVEINPEFAE 84

                         90       100       110
                 ....*....|....*....|....*....|
gi 938307548  66 KLAKKFgtiDNFLLLQDDflSLDVSKTLAQ 95
Cdd:COG3963   85 HLRRRF---PRVTVVNGD--AEDLAELLAE 109
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 6-71 1.54e-04

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 40.75  E-value: 1.54e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 938307548   6 RFAQHWLRSDAVLDKIvaaaQLSPRDRVLEIGPGQGVLTRRLFPLAESLLAVELDRDLCQKLAKKF 71
Cdd:COG2226    3 RVAARYDGREALLAAL----GLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARERA 64
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
17-88 2.42e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 40.75  E-value: 2.42e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 938307548  17 VLDKIVAAAQLSPRDRVLEIGPGQGVLTRRLFPLAESLLAVELDRDLCQKLAKKFGTIDnflLLQDDFLSLD 88
Cdd:COG4976   34 LAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREKGVYDR---LLVADLADLA 102
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 15-88 3.10e-04

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 39.62  E-value: 3.10e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 938307548  15 DAVLDKIVAAAQLSPRdRVLEIGPGQGVLTRRLFPLAESLLAVELDRDLCQkLAKKFGTIDNFLLLQDDFLSLD 88
Cdd:COG2227   11 DRRLAALLARLLPAGG-RVLDVGCGTGRLALALARRGADVTGVDISPEALE-IARERAAELNVDFVQGDLEDLP 82
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 20-70 1.36e-03

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 38.92  E-value: 1.36e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 938307548  20 KIVA----AAQLSPRDRVLEIGPGQG----VLTRrlfpLAESLLAVELDRDLcQKLAKK 70
Cdd:COG2518   53 YIVArmleALDLKPGDRVLEIGTGSGyqaaVLAR----LAGRVYSVERDPEL-AERARE 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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