|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
8-404 |
9.39e-105 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 316.99 E-value: 9.39e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 8 NVQTFINEQPFGGFQWLVFLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLG 87
Cdd:TIGR00895 1 DVQNNIRKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 88 RRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFL 167
Cdd:TIGR00895 81 RRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 168 AAWMIPHFGWRSVLMLGGVTPLLLGVLLLVKMPESVRFMVanSQPVDRIRATLARIS-RDALNAASFVMTETAPQTGSKG 246
Cdd:TIGR00895 161 AGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLV--SKRPETVRRIVNAIApQMQAEAQSALPEQKSTQGTKRS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 247 I-GVVLSRSYVVGSVMLWLAYFMGLVIFYASINWMPILLKEAGLTPKSATLISALFPLGGV-GAVLCGVLMDRFNAnRVI 324
Cdd:TIGR00895 239 VfKALFQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGViGSIIFGWLADRLGP-RVT 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 325 AVCYALTAVSVYAIGQAVGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGGIAGSFLVAEL 404
Cdd:TIGR00895 318 ALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
27-436 |
2.33e-102 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 309.13 E-value: 2.33e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 27 LMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVS 106
Cdd:cd17365 2 ALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 107 AFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSVLMLGGV 186
Cdd:cd17365 82 AFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 187 TPLllgvlllvkmpesvrfmvansqpvdriratlarisrdalnaasfvmtetapqtgskgIGVVLsrsyVVGSVMLWLAY 266
Cdd:cd17365 162 PPL---------------------------------------------------------ILLPL----LRGTLLLWVTF 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 267 FMGLVIFYASINWMPILLKEAGLTPKSATLISALFPLGGV-GAVLCGVLMDRFNANRVIAVCYALTAVSVYAIGQAVGNV 345
Cdd:cd17365 181 FMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGViGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASL 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 346 GLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGGIAGSFLVAELTRRHFTFAGVFATIAVAGVLS 425
Cdd:cd17365 261 VLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALG 340
|
410
....*....|.
gi 979579332 426 CVALLIKQTAR 436
Cdd:cd17365 341 ALAVLLLRLRR 351
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
28-404 |
6.21e-64 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 211.74 E-value: 6.21e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 28 MCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSA 107
Cdd:PRK11551 19 LCFLVALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 108 FSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSVLMLGGVT 187
Cdd:PRK11551 99 QAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVG 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 188 PLLLGVLLLVKMPESVRFMVANSQPVDRiratlarisrdalnaASFVMTETAPQTGSKgigvvlsrsyvvgSVMLWLAYF 267
Cdd:PRK11551 179 PLLLVPLLMRWLPESRAFAQAAGAGKQR---------------APVLRALFGEGRATA-------------TLLLWISYF 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 268 MGLVIFYASINWMPILLKEAGLTPKSATLISALFPLGG-VGAVLCGVLMDRFNANRVIAVCYALTAVSVYAIGQAVGNVG 346
Cdd:PRK11551 231 FTLIVLYFLLNWLPSLLVGQGLSRSQAGLVQIAFNIGGaLGSLLIGALMDRLRPRRVVLLIYAGILASLAALAAAPSFAG 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 979579332 347 LLvLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGGIAGSFLVAEL 404
Cdd:PRK11551 311 ML-LAGFAAGLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQL 367
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
15-431 |
5.52e-49 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 171.21 E-value: 5.52e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 15 EQPFGGFQWLVFLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLG 94
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 95 SVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPH 174
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 175 FGWRSVLMLGGVtplllgvlllvkmpesvrfmvansqpvdriratlarisrdalnaasfvmtetapqtgskgIGVVLSrs 254
Cdd:COG2271 161 FGWRAAFLILGL------------------------------------------------------------PGLLLA-- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 255 yVVGSVMLWLAYFMGLVIFYASINWMPILLKEA-GLTPKSATLISALFPLGG-VGAVLCGVLMDRFNANR--VIAVCYAL 330
Cdd:COG2271 179 -LLRFWLLALAYFLVYFALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGiVGSLLGGWLSDRLGRRRklVLAIGLLL 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 331 TAVSVYAIGQaVGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGGIAGSFLVAELTrRHFT 410
Cdd:COG2271 258 AALALLLLAL-LPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL-DATG 335
|
410 420
....*....|....*....|.
gi 979579332 411 FAGVFATIAVAGVLSCVALLI 431
Cdd:COG2271 336 YQAAFLLLAALALLAALLALL 356
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
26-430 |
8.30e-43 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 154.30 E-value: 8.30e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 26 FLMCFVIVLLDGFDTAAIGFIAPSLLTE--WHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAAC 103
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 104 FVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHF----GWRS 179
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 180 VLMLGGVTPLllgvlllvkmpesvrfmvansqpvdriratlarisrdalnaasfvmtetapqtgskgIGVVLSRSyvvgS 259
Cdd:cd17316 161 LFLIGALPAL---------------------------------------------------------LALLLRRR----T 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 260 VMLWLAYFMGLVIFYASINWMP-ILLKEAGLTPKSATLISALFPLGG-VGAVLCGVLMDRFNANRVIAVCYALTAVSVYA 337
Cdd:cd17316 180 LLLILLWFFISFGYYGLTTFLPtYLQTVLGLSPATSSLYLLLISLGAlVGALIAGLLSDRIGRKKTLVIGLILSGILALP 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 338 IGQAV-GNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGGIAGSFLVAELTRRHFTFAGVFA 416
Cdd:cd17316 260 LFYLLsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPAL 339
|
410
....*....|....
gi 979579332 417 TIAVAGVLSCVALL 430
Cdd:cd17316 340 ILALLAIVALIVAL 353
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
22-431 |
6.85e-39 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 144.64 E-value: 6.85e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 22 QWLVFLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGA 101
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 102 ACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSVL 181
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 182 MLGGVTPLLLGVLLLVKMPESVRFMVANSQPVDRIRATLARISRdalnaasfvmtetapqtgskgigvvlsrsyvvgSVM 261
Cdd:COG2223 163 LILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPR---------------------------------FWL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 262 LWLAYFMGLVIFYASINWMPILLKEA-GLTPKSATLISALFPL-GGVGAVLCGVLMDRFNANRVIAVCYALTAVSVYAIG 339
Cdd:COG2223 210 LSLLYFGTFGSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALlGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLA 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 340 QAVGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGGIAGSFLVAELTRRHFTFAGVFATIA 419
Cdd:COG2223 290 LALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFA 369
|
410
....*....|..
gi 979579332 420 VAGVLSCVALLI 431
Cdd:COG2223 370 VLALVALVLTLL 381
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
26-430 |
2.90e-38 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 142.83 E-value: 2.90e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 26 FLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFV 105
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 106 SAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIP----HFGWRsVL 181
Cdd:cd17371 81 CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPllppEIAWR-VL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 182 MLGGVTPLLLGVLLLVKMPESVRFmvansqpvdriraTLARISRDALNAASFVMTETAPQtgskgigvvLSRSYVVGSVM 261
Cdd:cd17371 160 FLLGALPALLVLFIRRFVKEPPQW-------------QAARAARRHFADRPSLRELFSPP---------LLRTTLLASLL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 262 LWLAYFmglvIFYASINWMPILLK-EAGLTPKSATLISALFPLGG-VGAVLCGVLMDRFNANRVIAVCYALTAVSVYAIG 339
Cdd:cd17371 218 ATGALG----GYYGITTWLPSYLTgERGLSFEGSAGYLVVTILGGfLGYLAGGFLADRIGRRNNFALFALGSAISILLYF 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 340 QAVGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGGIAGSFLVAELTrRHFTFAGVFATIA 419
Cdd:cd17371 294 FLPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLA-TSGSLGTAIAVFA 372
|
410
....*....|.
gi 979579332 420 VAGVLSCVALL 430
Cdd:cd17371 373 AVYYIAGLVLA 383
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
21-394 |
1.49e-35 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 134.72 E-value: 1.49e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 21 FQWLVFLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFG 100
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 101 AACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSV 180
Cdd:COG2814 87 LGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 181 LMLGGVTPLLLGVLLLVKMPesvrfmvansqpvdriratlarisrdalnaasfvmtETAPQTGSKGIGVVLSRSYVVGSV 260
Cdd:COG2814 167 FLVNAVLALLALLLLLRLLP------------------------------------ESRPAARARLRGSLRELLRRPRLL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 261 MLWLAYFMGLVIFYASINWMPILLKE-AGLTPKSATLISALFPLGG-VGAVLCGVLMDRFNANRVIAVCYALTAVSVYAI 338
Cdd:COG2814 211 LLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGvLGALLAGRLADRFGRRRLLLIGLLLLALGLLLL 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 979579332 339 GQAvGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGG 394
Cdd:COG2814 291 ALA-GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
23-431 |
4.87e-33 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 128.07 E-value: 4.87e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 23 WLVFLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAA 102
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 103 CFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSVLM 182
Cdd:cd17319 82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 183 LGGVtplllgvlllvkmpesvrfmvansqpvdriratlarisrdalnaASFVMtetapqtgskgigVVLSRSYVVGSVML 262
Cdd:cd17319 162 IEGL--------------------------------------------LGLLL-------------AVLWWFYLRQVWGL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 263 WLAYFMGLVIFYASINWMPILLKEA-GLTPKSATLISAL-FPLGGVGAVLCGVLMDRF---NANRVIAVCYALTAVSVYA 337
Cdd:cd17319 185 ALGYFGINYALYGLLTWLPTYLKQArGFSLKQVGLLAAIpFLAGAIGMILGGRLSDRLlrgARRLVIIIGLLLAAVGLLL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 338 IGqAVGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGGIAGSFLVAELTRRHFTFAGVFAT 417
Cdd:cd17319 265 AY-LTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLF 343
|
410
....*....|....
gi 979579332 418 IAVAGVLSCVALLI 431
Cdd:cd17319 344 LAAVALLAALLVLL 357
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
46-434 |
1.67e-26 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 111.65 E-value: 1.67e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 46 IAPSLLTEWHLTKPD--LAPVLSAALF-GLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVT 122
Cdd:TIGR00898 111 FSSTIVTEWDLVCEDawKVDLTQSCFFvGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLV 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 123 GVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLaAWMIPHfgWRsVLMLGGVTPLLLGVLLLVKMPES 202
Cdd:TIGR00898 191 GMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLVLLPLV-AYFIPD--WR-WLQLAVSLPTFLFFLLSWFVPES 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 203 VRFMVANSQPVDRIRATL--ARISRDALNAASFVMTETAPQTGSKGIG----VVLSRSYVVGSVMLWLAYFMGLVIFYAs 276
Cdd:TIGR00898 267 PRWLISQGRIEEALKILQriAKINGKKLPAEVLSLSLEKDLSSSKKQYsfldLFRTPNLRKTTLCLMMLWFTTAFSYYG- 345
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 277 inwMPILLKEAGLTPKSATLISAL--FPlggvGAVLCGVLMDRFNANRVIAVCYALTAVSVYAIGQAVGNVGLLVLIVFV 354
Cdd:TIGR00898 346 ---LVLDLGNLGGNIYLDLFISGLveLP----AKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRTALAV 418
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 355 AGVLMNTAQSSMPAL-AAAFYPTEGRGTGVAWMLGVGRFGGIAGSFLVAELTRRHFTFAGVFATIAVagVLSCVALLIKQ 433
Cdd:TIGR00898 419 LGKFGITSAFQMVYLyTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWLFLPLVLFGGLAL--LAGILTLFLPE 496
|
.
gi 979579332 434 T 434
Cdd:TIGR00898 497 T 497
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
22-310 |
3.21e-26 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 107.59 E-value: 3.21e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 22 QWLVFLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGA 101
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 102 ACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSVL 181
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 182 MLGGVtPLLLGVLLLVKMPESVRFMVAnsqpvDRIRATLARISRDALNAASFVMTETAPQTGSKGIGVVLSRSYVVGSVM 261
Cdd:COG0477 172 LINAP-LGLLALVLRLRLPESRGLLLA-----LLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLAL 245
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 979579332 262 LWLAYFMGLVIFYASINWMPILLKEAGLTPKSATLISALFPLGGVGAVL 310
Cdd:COG0477 246 LLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
28-398 |
5.89e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 107.89 E-value: 5.89e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 28 MCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSA 107
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 108 FSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSVLMLGGVT 187
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 188 PLLLgvlllvkmpesvrfmvansqpvdrirATLARISRDALNAASFVMTETAPQTGSKGIGVVLSRSYvvgsVMLWLAYF 267
Cdd:pfam07690 161 SLLA--------------------------AVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPV----LWLLLALL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 268 MGLVIFYASINWMPILLKEAGLTPKSATLISALFPLGG-VGAVLCGVLMDRFNANRVIAVCYALTAVSV--YAIGQAVGN 344
Cdd:pfam07690 211 LFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGaIGRLLLGRLSDRLGRRRRLLLALLLLILAAlgLLLLSLTLS 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 979579332 345 VGLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGGIAGS 398
Cdd:pfam07690 291 SLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
29-431 |
1.81e-23 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 101.11 E-value: 1.81e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 29 CFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAF 108
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 109 SSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSVLMLGGVTP 188
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 189 LLLGVLLLVKMPESVRFMVANSQPVDRIRATLARISRDALNAASFVMTetapqtgskgigvvlsrsyvvgsvmlwLAYFM 268
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAI---------------------------FVLAF 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 269 GLVIFYASInwmPILLKEAGLTpkSATLISALFPLGGVGAVLC----GVLMDRFNANRVIAVCYALTAVSVYAIGQAvGN 344
Cdd:cd17325 214 AFGALEPFL---PLYAAELGGL--SPAQIGLLFGAQGLASALSqppaGKLSDRIGRKPLILIGLLLSAVALLLLPLA-TS 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 345 VGLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGGIAGSFLVAELTRRhFTFAGVFATIAVAGVL 424
Cdd:cd17325 288 FWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDA-FGFATPFLAAAALLLL 366
|
....*..
gi 979579332 425 SCVALLI 431
Cdd:cd17325 367 AAVLFLL 373
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
30-430 |
9.70e-23 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 99.42 E-value: 9.70e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 30 FVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFS 109
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 110 SGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSVLMLGGVTPL 189
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 190 LLGVLllvkmpesvrfmvansqpvdrirATLARISRDALNAASFVMTETAPQTGSKGIGVVLSRSYVVGSVMLWLAYFMG 269
Cdd:cd06174 162 ALLAA-----------------------ILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 270 LVIFYASINWMpiLLKEAGLTPKSATLISALFPLGG-VGAVLCGVLMDRFNANRVIAVCYALTAVSVYAIGQAVGNVGLL 348
Cdd:cd06174 219 YYSFSTLLPLF--LLDLGGLSVAVAGLLLSLFGLAGaLGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLL 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 349 VLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGGIAGSFLVAELTRRHFTFAGVFATIAVAGVLSCVA 428
Cdd:cd06174 297 LLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
..
gi 979579332 429 LL 430
Cdd:cd06174 377 LL 378
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
23-431 |
1.69e-22 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 98.39 E-value: 1.69e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 23 WLVFLMCFVIVLlDGFDTAAIGfiaPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAA 102
Cdd:cd17324 2 LALALAAFAIGT-TEYVIQGLL---PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 103 CFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSVLM 182
Cdd:cd17324 78 NLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 183 LGGVTPLLLGVLLLVKMPESVRFMVANSQPVDRIRATLARIsrdalnaasfvmtetapqtgskgigvVLSRSYVVGSVMl 262
Cdd:cd17324 158 AIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNP--------------------------RLRLAYLITFLL- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 263 wlayFMGLVIFYASINwmPILLKEAGLTPKSATLISALFPLGG-VGAVLCGVLMDRFnANRVIAVCYALTAVSVYAIGQA 341
Cdd:cd17324 211 ----FGGFFALYTYLA--PFLTDVPGFSSSAIIGLLLLFGVAGvVGSPLAGRLADRG-GRRALLIALLLLAAALLLLTLL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 342 VGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPtEGRGTGVAWMLGVGRFGGIAGSFLVAELtrrhFTFAGVFATIAVA 421
Cdd:cd17324 284 GPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLV----LDHGGWAGVGWVG 358
|
410
....*....|
gi 979579332 422 GVLSCVALLI 431
Cdd:cd17324 359 AALLLLALLL 368
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
23-431 |
1.96e-22 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 98.41 E-value: 1.96e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 23 WLVFLMCFVIVLldgfdtaAIGFIAPSLLT---EWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLF 99
Cdd:cd17474 2 YAVFFATLLAVL-------GVSIVDPILPAiaeALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 100 GAACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINL----MFCGFPLGAAFGGFLAAWmiphf 175
Cdd:cd17474 75 GIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLyeaaLGLGIAVGPLLGGLLAAI----- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 176 GWRSVLMLGGVTPLLLGVLLLVKMPESVRfmvansqPVDRIRATLARISRDALNAASFVmtetapqtgskgigvvlsrsy 255
Cdd:cd17474 150 SWRYPFFLLAALIPVAFLAILFLLPEPKE-------KAKSSSATKLRDLKKALRGRGLL--------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 256 vvgsVMLWLAyFMGLVIFYASINWMPILLKEAGLTPKSAT--LISALFPLGGVGAVLCG-VLMDRFNANRVIAVCYALTA 332
Cdd:cd17474 202 ----TFLVSA-FLYFFLYFAFLTYLPFLLELLYGISPIIIglLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLLYA 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 333 VSVYAIGqAVGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAwMLGVGRFGGIAGSFLVAELTRRHFTFA 412
Cdd:cd17474 277 LSLLLLG-FVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASS-LYNFVRFLGQAVGPLLFGLLLEIFGLS 354
|
410
....*....|....*....
gi 979579332 413 GVFATIAVAGVLSCVALLI 431
Cdd:cd17474 355 APFLVGAAIALAAAVLLAL 373
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
10-211 |
1.12e-20 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 95.04 E-value: 1.12e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 10 QTFINEQPFGGFQWLVFLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRR 89
Cdd:TIGR01299 153 ELIIQECGHGRFQWALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRK 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 90 ALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAA 169
Cdd:TIGR01299 233 QCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAW 312
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 979579332 170 WMIPHFGWR------------SVLMLGGVTPLLLGVLLLVKMPESVRFMVANSQ 211
Cdd:TIGR01299 313 AIIPHYGWSfqmgsayqfhswRVFVIVCAFPCVFAIGALTFMPESPRFFLENGK 366
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
64-425 |
2.56e-20 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 91.89 E-value: 2.56e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 64 VLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPD 143
Cdd:cd17489 36 VVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPP 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 144 KRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSVLMLGGVTPLLlgvlllvkmpesvrfmvansqpvdriratlari 223
Cdd:cd17489 116 SRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALL--------------------------------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 224 srdALNAASFVMTETAPQTGSKGIGVVLSRSYVVGSVMLWLAYFMGLVIFYASI-NWMPILLKEAGLTpkSATLISALFP 302
Cdd:cd17489 163 ---ALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAIsTFLPLYAAERGIS--NAGLFFTVYA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 303 LGGVGA-VLCGVLMDRFNANRVIAVCYALTAVSVYAIGQAvGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGT 381
Cdd:cd17489 238 IALLLSrPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFA-GSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGA 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 979579332 382 GVAWMLGVGRFGGIAGSFLVAELTrRHFTFAGVFATIAVAGVLS 425
Cdd:cd17489 317 ANGTFFIFFDLGIGLGGLLLGLVA-ELFGYRAMFLLAAVVVLLA 359
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
36-429 |
2.67e-20 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 92.18 E-value: 2.67e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 36 DGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQL 115
Cdd:cd17441 11 DAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 116 TVLRFVTGVGLGAAmPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSVLMLGGVtPLLLGVLL 195
Cdd:cd17441 91 LVLRGLVGFGIGGV-PQSVTLYAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSAL-PLLIFAVL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 196 LVKMPESVRFmvansqpvdriRATLARISRDALNAASF-----VMTETAPQTGSKGIGvvlSRSYVVGSVMLWLAYFMgl 270
Cdd:cd17441 169 CFWLPESARY-----------WTTILLWFIWFSNAFSYyglvlLTTELFQAGDVCSGS---SGKKVEGKCSLECEYLT-- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 271 vifyaSINWMPILlkeagltpkSATLisALFPlggvGAVLCGVLMDRFNANRVIAVCYALTAVSVYAIGQAVGNVGLLVL 350
Cdd:cd17441 233 -----TSDYMDLL---------WTTL--SEFP----GLLVTLWIIDRFGRKKTMALCFFVFSFCTLLLFSCVGRFSLTVL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 351 IvFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGGIAGSFLVAELTRRHFTFA-GVFATIAVAGVLSCVAL 429
Cdd:cd17441 293 L-FIARAFISGGFQAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIAQVMLESSVYLTlSVYSGCCLLAAIASCFL 371
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
22-430 |
3.08e-20 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 91.57 E-value: 3.08e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 22 QWLVFLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGA 101
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 102 ACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSVL 181
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 182 MLGGVTPLLLGVLllvkmpesVRFMVANSQPVdriratlarisrdalnaasfvmtetapqtgskgigvvlsrsyvvgSVM 261
Cdd:cd17312 161 LVPGIVGLVVAII--------LFFFLRDSPPY---------------------------------------------VWV 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 262 LWLAYFMGLVIFYASINWMPILLKE-AGLTPKSATLISALFPLGG-VGAVLCGVLMDR-FNANR--VIAVCYALTAVSVY 336
Cdd:cd17312 188 LSLAYAFVYIVRYACLDWGPLYLYEvKGYSLIDAGWFSSLYEVGGiAGTILAGLLSDKlFGGRRapIAVIYMLLMTLSLA 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 337 AIGQAVGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPT-EGRGTGVAWMLGVGRFGGIAGSFLVAELTrRHFTFAGVF 415
Cdd:cd17312 268 LFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRkEAAGTATGFVGLFGYLGASLAGLPLGYII-DHYGWSTVF 346
|
410
....*....|....*
gi 979579332 416 ATIAVAGVLSCVALL 430
Cdd:cd17312 347 YFLISAALLSVLLLL 361
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
34-213 |
1.94e-19 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 89.55 E-value: 1.94e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 34 LLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIE 113
Cdd:cd17359 11 LLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFT 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 114 QLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINL--------MFCGFPLGAAFGGFLAAWMIPHFGWRsvLMLG- 184
Cdd:cd17359 91 IFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLnqlmivfgQLLAYIVNYLIANAGGADWLGAEGWR--WMLGl 168
|
170 180
....*....|....*....|....*....
gi 979579332 185 GVTPLLLGVLLLVKMPESVRFMVANSQPV 213
Cdd:cd17359 169 EAIPAILFLLGMLFIPESPRWLVSKGKPI 197
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
22-408 |
2.58e-19 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 90.14 E-value: 2.58e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 22 QWLVFLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGA 101
Cdd:PRK03893 18 QWKAFSAAWLGYLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 102 ACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSvL 181
Cdd:PRK03893 98 GTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRA-L 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 182 MLGGVTPLLLGVLLLVKMPESVRF--MVANSQPVDRIRATLARISRDALNAASFVMTETA------PQTGSKGIGVVLsr 253
Cdd:PRK03893 177 FFIGILPIIFALWLRKNLPEAEDWkeKHAGKAPVRTMVDILYRGEHRIINILLTLAAAAAlwfcfaGNLQNAAIVAVL-- 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 254 SYVVGSVMLWLAY-FMG----------LVIFYASINWMPI-------LLKEAGLTPKSATLISALFPLG-GVGAVLCGVL 314
Cdd:PRK03893 255 GLLCAAIFISFMVqSSGkrwptgvmlmVVVLFAFLYSWPIqallptyLKTDLGYDPHTVANVLFFSGFGaAVGCCVGGFL 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 315 MDRFNANRVIAVCY---ALTAVSVYAIGQavGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWMLGVGR 391
Cdd:PRK03893 335 GDWLGTRKAYVCSLlisQLLIIPVFAIGG--ANVWVLGLLLFFQQMLGQGISGLLPKLIGGYFDTEQRAAGLGFTYNVGA 412
|
410
....*....|....*..
gi 979579332 392 FGGIAGSFLVAELTRRH 408
Cdd:PRK03893 413 LGGALAPILGALIAQRL 429
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
30-431 |
6.36e-19 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 88.02 E-value: 6.36e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 30 FVIVLLDGFDTAAIGFIAPSLL---TEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVS 106
Cdd:cd17320 2 LLLALLVALGPLAIDMYLPALPaiaRDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 107 AFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSV---LML 183
Cdd:cd17320 82 ALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIfvfLAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 184 GGVtplLLGVLLLVKMPEsvrfmvanSQPVDRIRATLARISRDALNaasfvmtetapqtgskgigvVLSRSYVVGSVMLW 263
Cdd:cd17320 162 LGL---LLLLLVLLFLPE--------TLPEEKRKPLLSSLLRAYKR--------------------VLKNRRFLGYALAL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 264 LAYFMGLVIFYASinwMPILLKEA-GLTPKS-ATLISALFPLGGVGAVLCGVLMDRFNANRVI--AVCYALTAVSVYAIG 339
Cdd:cd17320 211 GLSFAGLFAYLAA---APFIYIEQlGLSPAQfGLLFALNAIALILGSLLNGRLVRRFGPRRLLrlGLLLLLAAALVLLLA 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 340 QAVGNVGLLVLIVFVAGVL--MNTAQSSMPALAAAFYPtEGRGTGVAWMLGVGRFGGIAGSFLVAELtrrHFTFAGVF-A 416
Cdd:cd17320 288 ALLGGLSLWPLVAPLFLIFfgFGLIFPNATSLALEPFP-HVAGTASALLGFLQFLIGALAGALVGLL---PNGTALPMgL 363
|
410
....*....|....*
gi 979579332 417 TIAVAGVLSCVALLI 431
Cdd:cd17320 364 LILVLGLLALLLLIL 378
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
30-415 |
1.95e-18 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 86.66 E-value: 1.95e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 30 FVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFS 109
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 110 SGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFG-GFLAAWMIPHFGWRSVLMLGGVTP 188
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLpPLVLFGIAELYSWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 189 LLLGVlllvkmpesVRFMVANSQPVDRIRATLarisRDALNAASFVMTETAPQTGSKGIGVVlsrSYVVGSVMLWLAYFM 268
Cdd:TIGR00881 161 IIVSL---------ICFLLLRDSPQSCGLPPA----EEMPNEEPDGDAEKKEEELTKKQIFL---QYVLLNKVLWYISLG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 269 GLVIF---YASINWMPILLKEA-GLTPKSATLISALFPLGG-VGAVLCGVLMDR-FNANRVIAVCYALTAVSVYAIG--- 339
Cdd:TIGR00881 225 YVFVYvvrTGILDWSPLYLTQEkGFSKEKASWAFTLYELGGlVGTLLAGWLSDKlFNGRRGPLAVFFMALIIVSLLVywl 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 979579332 340 QAVGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWmlgVGRFGGIAGSF--LVAELTRRHFTFAGVF 415
Cdd:TIGR00881 305 NPAANPLMDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGF---VGFFAYLGGILagLPLGYLADGFGWAGAF 379
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
23-431 |
1.15e-17 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 84.54 E-value: 1.15e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 23 WLVFLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAA 102
Cdd:COG2807 17 WLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 103 CFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDkRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSVLM 182
Cdd:COG2807 97 LLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 183 LGGVTPLLLGVLLLVKMPESVRfmvanSQPVDRIRATLARISRDALnaasfvmtetapqtgskgigvvlsrsyvvgSVML 262
Cdd:COG2807 176 VWALLALLALLLWLPLLRRRPA-----AAAAAPAAASLRSLWRSPL------------------------------AWLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 263 WLAYFMGLVIFYASINWMPILLKEAGLTPKSATLISALFPLGGV-GAVLCGVLMDRFNANR-VIAVCYALTAVSVyaIGQ 340
Cdd:COG2807 221 TLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIpGSLLVPLLADRLGDRRpLLLLLGLLGLAGL--LGL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 341 AVGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPT-EGRGTGVAWMLGVGRFGGIAGSFLVAELTRRHFTFAGVFATIA 419
Cdd:COG2807 299 LLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTpAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLA 378
|
410
....*....|..
gi 979579332 420 VAGVLSCVALLI 431
Cdd:COG2807 379 ALAVLMLVAGLL 390
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
63-431 |
8.45e-17 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 81.47 E-value: 8.45e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 63 PVLSAALFglacgALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCP 142
Cdd:cd17473 44 PALFIALF-----APLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 143 DKRRATVINLMFCGFPLGA----AFGGFLAAwmiphFGWRSVLMLGGVtPLLLGVLLLVKMPESVRfmvansqpvdrira 218
Cdd:cd17473 119 GEERAKMLGLQSAAMSLGGvvflLLGGALAE-----IGWRAPFLVYLL-ALPVLILVLLFLPEPAR-------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 219 tlarisrdalnaasfvmtetaPQTGSKGIGVVLSRSYVVGSVMLWLAY-FMGLVIFYASINWMPILLKEAGLT-PKSATL 296
Cdd:cd17473 179 ---------------------KSKSAASPGAATAAALPWKRVLPIYFLaFLAMLLFYVIPIQLPFLLQERGGGsAALIGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 297 ISALFPLGG-VGAVLCGVLMDRFNANRVIAVCYALTAVSVYAIGQAvGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYP 375
Cdd:cd17473 238 ALAIASLAGaIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALA-SGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVP 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 979579332 376 TEGRGTGVAWMLGVGRFGGIAGSFLVAELTRRHFTFAGVFATIAVAGVLSCVALLI 431
Cdd:cd17473 317 PELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
33-421 |
2.79e-16 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 79.91 E-value: 2.79e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 33 VLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGI 112
Cdd:cd17321 5 VFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 113 EQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSVLMLggvtplllg 192
Cdd:cd17321 85 AFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLI--------- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 193 vlllvkmpeSVRFMVansqpvdriratlarisrdalnaasfvmtetapqtgskgIGVVLSRSYVVGSVMLWLAYFMGLVI 272
Cdd:cd17321 156 ---------NVPIGL---------------------------------------VALLLARTFSGAVLAAFLLGAALGGL 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 273 FYasinWMPILLKEA-GLTPKSATLISALFPLG-GVGAVLCGVLMDRFNANRVIAVCYALTAVSVYAIGQAVGNVGLLVL 350
Cdd:cd17321 188 LF----LLPLYLQGVlGYSPLQAGLALLPLALAmLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLL 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 351 IV----------FVAGVLMNTAQSSMPA----LAAAFYPTeGRGTGVAwmLGVGRFGGIAGSFLVAELTRRHFTFAGVFA 416
Cdd:cd17321 264 LPglvllglglgLFATPLTNAALSSVPKekagAASGILNT-ARQLGGA--LGVALLGALLTAGLSANLGDSGVAALLSAA 340
|
....*
gi 979579332 417 TIAVA 421
Cdd:cd17321 341 AAAFA 345
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
23-424 |
4.23e-16 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 79.51 E-value: 4.23e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 23 WLVFLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAA 102
Cdd:COG0738 7 RRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 103 CFVSAFSSGIEQLTVLRFVTGVGLG---AAMPNAVTMMGefcpDKRRATVINLMFCGFPLGAAFGGFLAAWMIPH---FG 176
Cdd:COG0738 87 LLLFALAPSYPLLLLALFLLGLGLGlldVAANPYVAALG----PETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 177 WRSV-LMLGGVTPLLLGVLLLVKMPESVRfmvansqpvdriratlarisrdalnaasfvmTETAPQTGSKGIGVVLSRSY 255
Cdd:COG0738 163 WHLPyLILAVLLLLLALLFLRSKLPEIEE-------------------------------EEEEAAGSAASLKSLLKNPR 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 256 VVGSVMLWLAYFMGLVIFYasiNWMPILLKEA-GLTPKSATLISALFPLG-GVGAVLCGVLMDRFNANRVIAVCYALTAV 333
Cdd:COG0738 212 LLLGGLAIFLYVGAEGAIG---DWLPLYLKDVlGLSEATAALGLSLFWGGmTIGRFLGGFLLKRFGPVRLLRLSALLAAV 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 334 SVYAIGqAVGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEGrGTGVAWMLGVGRFGGIAGSFLVAELTrRHFTFAG 413
Cdd:COG0738 289 GLLLAL-LAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLA-DAFGLRA 365
|
410
....*....|.
gi 979579332 414 VFATIAVAGVL 424
Cdd:COG0738 366 AFLVPLVCYLL 376
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
28-431 |
9.09e-16 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 79.24 E-value: 9.09e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 28 MCFVIVL---LDGFDTAAIGFIAPSL-----------LTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLL 93
Cdd:pfam00083 1 VALVAALggfLFGYDTGVIGAFLTLIdffknfglsksVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 94 GSVFLFGAACFVSAFS---SGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLmfcgFPLGAAFGGFLAAW 170
Cdd:pfam00083 81 IANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSL----YQLAITFGILLAYI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 171 M-------IPHFGWRSVLMLGGVtPLLLGVLLLVKMPESVRFMVANSQpVDRIRATLARISRDALNAASFV----MTETA 239
Cdd:pfam00083 157 FglglnktSNSDGWRIPLGLQLV-PALLLIIGLLFLPESPRWLVEKGR-LEEAREVLAKLRGVPDVDRELDeikdSLEAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 240 PQTGSKGIGVVLSRSYVVGSVMLWLAYFMGL------VIFYASinwmPILLKEAGLTPksATLISALFPLGGVGAVLCGV 313
Cdd:pfam00083 235 QEAEKASWKELFSTKTRRQRLLIGVMLQIFQqltginAIFYYS----TTIFENLGLSD--SFLVTIIVGVVNFVFTFIAI 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 314 -LMDRFNANR-------VIAVCYALTAVSVYAI--GQAVGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGv 383
Cdd:pfam00083 309 fLVDRFGRRPllllgaaGMAICFVILGIVALLGvsKSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKA- 387
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 979579332 384 awmLGVGRFGGIAGSFLVAELTRRHFTFAGVFATIAVAGVLSCVALLI 431
Cdd:pfam00083 388 ---MALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIF 432
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
33-211 |
2.47e-15 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 77.76 E-value: 2.47e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 33 VLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGI 112
Cdd:cd17439 8 LMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGY 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 113 EQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWR------------SV 180
Cdd:cd17439 88 GTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSfqmgsayqfhswRV 167
|
170 180 190
....*....|....*....|....*....|.
gi 979579332 181 LMLGGVTPLLLGVLLLVKMPESVRFMVANSQ 211
Cdd:cd17439 168 FVLVCAFPSVFAIGALTTMPESPRFFLENGK 198
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
49-426 |
3.86e-15 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 76.08 E-value: 3.86e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 49 SLLTEWHLT---KPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVG 125
Cdd:cd17317 12 TIVTEWDLVcdrDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVT 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 126 LGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLaAWMIPHfgWRSvlmlggvtplllgvlllvkmpesvrF 205
Cdd:cd17317 92 SAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALL-AYLIRD--WRW-------------------------L 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 206 MVANSQPvdriratlarisrdalnaasfvmtetapqtgskgigvvlsrsyvvGSVMLWLAYFMGLVIFYASINWMPILLK 285
Cdd:cd17317 144 QLAISLP---------------------------------------------GLLFLLLLWWLPRRTIIVGLIWFVTSLV 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 286 EAGLTPKSATL----ISALFPLGGV---GAVLCGVLMDRFNANRVIAVCYALTAVSVYAIGQAVGNVGLLVLIVFVAGVL 358
Cdd:cd17317 179 YYGLSLNSSNLggnlYLNFFLSGLVeipAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLALTLALVGKF 258
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 359 MNT-AQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGGIAGSFLVAELTRRHFTFAGVFATIA-VAGVLSC 426
Cdd:cd17317 259 AISaAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKIGPLLPLIIFGVLAlLGGLLTL 328
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
59-431 |
1.86e-14 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 74.87 E-value: 1.86e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 59 PDLAPVLSAALFGLA-----CGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQ--------LTVLRFVTGVG 125
Cdd:cd17369 39 PAAGTLAAFATFGVGflarpLGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYAQigilapilLVLLRLLQGLA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 126 LGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLG---AAFGGFLAAWMIPH-----FGWR------SVLMLGGVtplll 191
Cdd:cd17369 119 LGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGlllATGVFLLLSALLSDeaflsWGWRipfllsAVLVAVGL----- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 192 gvLLLVKMPESvrfmvansqPVdriratlarisrdalnaasFVMTETAPQTGSKGIGVVLSRSY--VVGSVmlwLAYFMG 269
Cdd:cd17369 194 --YIRLRLEET---------PV-------------------FRRAKEAGQVVRAPLVEVLRRHWraLLLAI---GLRLAE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 270 LVIFYASINWMPILLKEAGLTPKSATLISALFP--LGGVGAVLCGVLMDRFNANRVIAVCYALTAVSVYAIGQAV---GN 344
Cdd:cd17369 241 NVLFYLFTTFALSYATQTLGVDRSTVLLAVLIAsvVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLdtgST 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 345 VGLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVA--WMLGVGRFGGIAgSFLVAELTRRHFTFAGVFATIAVAG 422
Cdd:cd17369 321 WLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASlgYQLGAILGGGFA-PLIATALVAATGSWWPVALYLAALA 399
|
....*....
gi 979579332 423 VLSCVALLI 431
Cdd:cd17369 400 VISLVAALF 408
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
26-207 |
6.19e-14 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 73.42 E-value: 6.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 26 FLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFV 105
Cdd:cd17438 1 FFVLGLALMADGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 106 SAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWR------- 178
Cdd:cd17438 81 SSFVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGWGfsmgtny 160
|
170 180 190
....*....|....*....|....*....|....
gi 979579332 179 -----SVLMLGGVTPLLLGVLLLVKMPESVRFMV 207
Cdd:cd17438 161 hfhswRVFVIICALPCIASIIALKFMPESPRFLL 194
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
41-430 |
3.39e-13 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 70.73 E-value: 3.39e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 41 AAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLG-RRALLLGSVFLfGAACFVSAFSSGIEQLTVLR 119
Cdd:cd17475 13 QGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGeRRVLAVGLLLM-GAAALLMALVGSYPVLLVLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 120 FVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSVLMLGGVTPLLLGVLLLVKM 199
Cdd:cd17475 92 FLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFY 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 200 PESVRFMVANSQPVDRIRATLARI-SRDALNAASFVMTETAPQTGskgigvvlsrsyVVGSVMLWLAYFMGLVIfyasin 278
Cdd:cd17475 172 REPPAASAATESASTLLRSLKEVLrNRDVWLIAIAGALLVAPQFA------------LLTFLLLFLHDHLGLSV------ 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 279 wmpillkeagltPKSATLISALFPLGGVGAVLCGVLMDRFNANR-----VIAVCYALTAVSVYAIGQAVGNVGLLVLIVF 353
Cdd:cd17475 234 ------------VAAGALLAVAQLGGALGRIGLGRVSDRVFGGRrrpvlVITAAIAAAALLVLSLLSPGTPLWLLVLLLI 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 979579332 354 VAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGGIAGSFLVAELTRRHFTFAGVFATIAVAGVLSCVALL 430
Cdd:cd17475 302 LLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
36-211 |
4.97e-13 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 70.60 E-value: 4.97e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 36 DGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQL 115
Cdd:cd17363 11 DGVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 116 TVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWR------------SVLML 183
Cdd:cd17363 91 LFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIGGLYASAMAWAIIPHYGWGfsmgtayqfhswRVFVI 170
|
170 180
....*....|....*....|....*...
gi 979579332 184 GGVTPLLLGVLLLVKMPESVRFMVANSQ 211
Cdd:cd17363 171 VCALPSVASVVALTFMPESPRFLLEVGK 198
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
22-357 |
8.28e-13 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 69.67 E-value: 8.28e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 22 QWLVFLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGA 101
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 102 ACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSVL 181
Cdd:cd17343 81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 182 MLGGVTPLLLGVlllvkmpesVRFMVANSQPVDrirATLARISRDalNAASFVMTETAPQTgskgigvvlSRSYVVGSVM 261
Cdd:cd17343 161 SISGTVAVVMSV---------VCLLFIKNEPSD---VGLNNIEEE--ESKGKKKKSPRGES---------TLKELLLSPF 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 262 LWLAYFMGLVIF---YASINWMPI-LLKEAGLTPKSATLISALFPLGG-VGAVLCGVLMDRFNANRViavcyaltavsvy 336
Cdd:cd17343 218 LWLLSLGYLVVFgvkTAVTDWGQLfLIQDKGQSALTGSSFMSSLEVGGfVGSIAAGYLSDWAVAKHG------------- 284
|
330 340
....*....|....*....|.
gi 979579332 337 aiGQAVGNVGLLVLIVFVAGV 357
Cdd:cd17343 285 --SSSRGNPRMPLALVFMAGL 303
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
65-186 |
9.83e-13 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 69.33 E-value: 9.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 65 LSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDK 144
Cdd:TIGR00710 46 LTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGE 125
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 979579332 145 RRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRS---VLMLGGV 186
Cdd:TIGR00710 126 ELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAifaFLSLAGI 170
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
43-186 |
1.17e-12 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 69.10 E-value: 1.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 43 IGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVT 122
Cdd:cd17372 18 LSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLV 97
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 979579332 123 GVGLGAAmPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSVLMLGGV 186
Cdd:cd17372 98 GLGLGGG-PQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSSV 160
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
65-180 |
2.82e-12 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 68.00 E-value: 2.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 65 LSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLGAAmpnAVTMMGeFCPDK 144
Cdd:PRK11043 47 LSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCSA---AVIWQA-LVIDR 122
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 979579332 145 RRATVINLMFCG-FPLGA---AFGGFLAAWMIPHFGWRSV 180
Cdd:PRK11043 123 YPAQKANRVFATiMPLVAlspALAPLLGAWLLNHFGWQAI 162
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
26-207 |
5.79e-12 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 67.25 E-value: 5.79e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 26 FLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFV 105
Cdd:cd17440 1 FFVLGMALMADGVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 106 SAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWR------- 178
Cdd:cd17440 81 SSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSfsmgsay 160
|
170 180 190
....*....|....*....|....*....|....
gi 979579332 179 -----SVLMLGGVTPLLLGVLLLVKMPESVRFMV 207
Cdd:cd17440 161 qfhswRVFVIVCALPCVSSVVALTFMPESPRFLL 194
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
22-430 |
7.80e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 66.53 E-value: 7.80e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 22 QWLVFLMCFVIVLLD-GFDTAAIGFIAPsLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFG 100
Cdd:cd17355 1 GWVVLAVTFLILILSwGIRYYFGVFIIP-IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 101 AACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFC-PDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRS 179
Cdd:cd17355 80 AGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWwFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 180 -VLMLGGVTPLLLGVLLLVKMPESVRfmVANSQPVDRIRATLARISRDALNAASFvmtetapqtgskgigvvlsrsyvvg 258
Cdd:cd17355 160 aLLVLALLALLVLVPVLLLLRRRPAD--LALRAYDDASPASPGSTLKEALRSASF------------------------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 259 sVMLWLAYFMGLVIFYASINWMPILLKEAGLTPKSATLISALFPLGGV-GAVLCGVLMDRFNANRVIAVCYALTAVSVYA 337
Cdd:cd17355 213 -WLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIvGRLLSGWLGDRYSPRRLLAASYALRALGLAL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 338 IGQAVGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGGIAGSFLVAELTRRHFTFAGVFAT 417
Cdd:cd17355 292 LLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWAL 371
|
410
....*....|...
gi 979579332 418 IAVAGVLSCVALL 430
Cdd:cd17355 372 AVALGLIAALLVL 384
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
25-180 |
9.95e-12 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 66.06 E-value: 9.95e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 25 VFLMCFvIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACF 104
Cdd:cd17323 1 VFIISF-LTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 979579332 105 VSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVInLMFCGFP-LGAAFGGFLAAWMIPHFGWRSV 180
Cdd:cd17323 80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAM-GVYSLGPlLGPALGPIIGGFITQSLGWRWI 155
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
34-208 |
2.45e-11 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 64.90 E-value: 2.45e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 34 LLDGFDTAAIGFIAPSLLTEWHLTKPDLAP--VLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSG 111
Cdd:cd17315 7 LLFGYDLGVINGALLYIAKDLGFGLSTSLQglVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPN 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 112 IEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRR---ATVINLMFCGFPLGAAFGGFLAAWMIPHfGWRsvLMLGGVT- 187
Cdd:cd17315 87 VWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRgalGTLNQLMITFGILLAYLLGLALSLSPPG-WWR--LMFALAAv 163
|
170 180
....*....|....*....|.
gi 979579332 188 PLLLGVLLLVKMPESVRFMVA 208
Cdd:cd17315 164 PALLQLLLMFFLPESRALLVG 184
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
65-127 |
3.54e-11 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 64.57 E-value: 3.54e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 979579332 65 LSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLG 127
Cdd:PRK15402 54 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLC 116
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
26-431 |
3.62e-11 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 64.55 E-value: 3.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 26 FLMCFVIVLLDGFdtaaiGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLG-RRALLLGSVfLFGAACF 104
Cdd:cd17353 10 VLMHLILGYQYAW-----SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGpRKAILIGGI-LFGLGFI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 105 VSAFSSGIEQLT-VLRFVTGVGLGAAMPNAVTMMGEFCPDKrRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSVLML 183
Cdd:cd17353 84 LSAFAISLPLLFlGYGVLGGIGAGIGYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 184 GGVtplllgVLLLVKMPESVRFMVANSQPVDRIRATLARISRDALNAASFVMTETAPQTgskgigvvlsrsyvvgsVMLW 263
Cdd:cd17353 163 LGI------IFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPRDYTPREMLRTPTF-----------------WLLW 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 264 LAYFMG-LVIFYASINWMPILLKEAGLTPKSATLISALFPLG-GVGAVLCGVLMDRFNANRVIAVCYALTAVSVYAIGQA 341
Cdd:cd17353 220 LMFFLNaTAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFnGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFI 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 342 VGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGGIAGSFLVAELTrrhfTFAGVFATIAVA 421
Cdd:cd17353 300 GSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVL----YTGGYNAAFIIA 375
|
410
....*....|
gi 979579332 422 GVLSCVALLI 431
Cdd:cd17353 376 AALSLVALAL 385
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
65-220 |
5.59e-11 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 63.78 E-value: 5.59e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 65 LSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTgvGLGAAMPNAVT---MMGEFC 141
Cdd:PRK11102 32 LSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLH--GLAAAAASVVInalMRDMFP 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 142 PDK--RRATVINLMFCGFPLGAAF-GGFLAAWmiphFGWRSVLMLGGVTPLLLGVLLLVKMPESVRfmVANSQPVdRIRA 218
Cdd:PRK11102 110 KEEfsRMMSFVTLVMTIAPLLAPIiGGWLLVW----FSWHAIFWVLALAAILAAALVFFFIPETLP--KERRQPF-HLRT 182
|
..
gi 979579332 219 TL 220
Cdd:PRK11102 183 TI 184
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
76-202 |
6.48e-11 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 59.97 E-value: 6.48e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 76 ALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFC 155
Cdd:TIGR00880 15 SPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSA 94
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 979579332 156 GFPLGAAFGGFLAAWMIPHFGWRSVLMLGGVTPLLLGVLLLVKMPES 202
Cdd:TIGR00880 95 GIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
71-168 |
7.40e-11 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 63.08 E-value: 7.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 71 GLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVI 150
Cdd:cd17374 47 GLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAI 126
|
90
....*....|....*...
gi 979579332 151 NLMFCGFPLGAAFGGFLA 168
Cdd:cd17374 127 TLTSCFFSIGQMLLAGLA 144
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
27-180 |
7.70e-11 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 63.34 E-value: 7.70e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 27 LMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVS 106
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLT 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 979579332 107 --AFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSV 180
Cdd:cd17380 82 plLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSV 157
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
48-180 |
1.20e-10 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 62.98 E-value: 1.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 48 PSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGlG 127
Cdd:cd17504 20 PTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIG-G 98
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 979579332 128 AAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSV 180
Cdd:cd17504 99 AVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWI 151
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
70-377 |
3.51e-10 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 61.48 E-value: 3.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 70 FGLACGALVSGP----LSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKR 145
Cdd:cd17328 41 TVFIISYMVLSPifgyLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 146 RATVINLMFCGFPLGAAFGGFLAAWMIPHF-GWRSVLMLGGVTPLLLGVLLLVKMPESVRFMVANSQPVDRIRATLARIS 224
Cdd:cd17328 121 RTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 225 RDALNAASFVMTeTAPQTGskgigvvlsRSYVVGSvmlwLAYFMGLVIFYASinwmpillkeaGLTPKSATLISALFPLG 304
Cdd:cd17328 201 KALAKNPSFILS-TLGFTA---------VSFVTGA----LAFWAPTFFLRAF-----------GVGDLSSADVGLIFGAI 255
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 979579332 305 GVGAVLCGVLMDRFNANRviavcYALTAVSVYAIgqaVGNVGLLVLIVFVAgVLMNTAQSSMPALAAAFYPTE 377
Cdd:cd17328 256 TCIAGVLGVLLGGILADR-----LRRKTPRADPL---VCAVGLLAAAPFLF-LALVLALSNLLLAWVLLFLGE 319
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
66-180 |
6.19e-10 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 60.27 E-value: 6.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 66 SAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKR 145
Cdd:cd17502 37 TAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRE 116
|
90 100 110
....*....|....*....|....*....|....*
gi 979579332 146 RATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSV 180
Cdd:cd17502 117 RGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWC 151
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
33-188 |
1.14e-09 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 59.98 E-value: 1.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 33 VLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLS-----AALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSA 107
Cdd:cd17364 8 FFTDAYDLFSISLVTKILGRLYYGGKGSLPSGVSglvnaAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 108 FSSGIE------QLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFC----GFPLGA--------AFGGFLAA 169
Cdd:cd17364 88 LSPGSTplgvmgWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAmqgfGILAGAivtlilsaIFEHPLPA 167
|
170 180
....*....|....*....|.
gi 979579332 170 WMIPH--FGWRSVLMLGGVTP 188
Cdd:cd17364 168 GTYHHadLVWRIVLGLGAIPA 188
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
23-187 |
1.62e-09 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 59.10 E-value: 1.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 23 WLV-FLMCFVIVLLDGFDTAaIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGA 101
Cdd:cd17352 2 WVVvFASFLVNFFTDGILNS-FGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 102 ACFVSAFSSGIEQLTV-LRFVTGVGLGAAMPNAVTMMGEFCpDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWR-S 179
Cdd:cd17352 81 GLLLSSFATSLWQLYLtYGVLGGLGLGLIYSPAIVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRgA 159
|
....*...
gi 979579332 180 VLMLGGVT 187
Cdd:cd17352 160 LLILGGLC 167
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
34-202 |
1.66e-09 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 59.56 E-value: 1.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 34 LLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIE 113
Cdd:PRK12307 28 VFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVI 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 114 QLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFplgaAFGGFLAAWMIPHF----GWRSVLMLgGVTPL 189
Cdd:PRK12307 108 MLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGF----GIGNIIAAYFMPSFaeayGWRAAFFV-GLLPV 182
|
170
....*....|...
gi 979579332 190 LLGVLLLVKMPES 202
Cdd:PRK12307 183 LLVIYIRARAPES 195
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
34-435 |
2.19e-09 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 59.23 E-value: 2.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 34 LLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLS-AALFGLA-----CGALVSGPLSDRLGRRALLLGSVFLFGAACFVSA 107
Cdd:cd17367 9 LVEWYDWYVYAAFALYFAPQFFPSGDPTVALLStAAVFAVGflmrpIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 108 FSSGIEQ--------LTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRA--------TVINLMFCGFPLGAAFGGFLAAWM 171
Cdd:cd17367 89 VTPTYATigiwapiiLLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGfyssfqyvTLIGGQLLALGVLLVLQHTLGEDQ 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 172 IPHFGWRSVLMLGGVTpLLLGVLLLVKMPESVRFMVANSQPVDR--IRATLARISRDALnaasfvmtetapqtgskgigv 249
Cdd:cd17367 169 MAAWGWRIPFLLGGVL-AVVVLWLRRGLEETESFEAIAESNEASagTLRELRRHPRELL--------------------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 250 vlsrsYVVGSVMLwlayfmGLVIFYASINWMPILLKE-AGLTPKSATLISALFPL-GGVGAVLCGVLMDRFNANRV---I 324
Cdd:cd17367 227 -----LVVGLTAG------GTLAFYTWTTYLQKFLVNtAGFSKGDATWITTAALLvFMLLQPLGGRLSDRIGRRPLllfF 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 325 AVCYALTAVSVYAIGQAVGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVA--WMLGVGRFGGIAgSFLVA 402
Cdd:cd17367 296 GIGGTLATVPLLSALDHTDSPYTAFALVLVGLVFLSGYTSINAVVKAELFPTHVRALGVGlpYALAVAIFGGTA-PYVAL 374
|
410 420 430
....*....|....*....|....*....|...
gi 979579332 403 ELTRRHFTFAGVFATIAVAGVLSCVALLIKQTA 435
Cdd:cd17367 375 WLKSIGHEWVFFWYVAGLIAISLVVYLRMPETR 407
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
26-317 |
2.96e-09 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 58.74 E-value: 2.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 26 FLMCFVIVLLDGFDTAAIGFIAPSL-------LTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFL 98
Cdd:cd17358 1 LLATFVANLGSFSFGIAVGWSSPALpslmsdnSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 99 FGAACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVInlmfCGFPLGAAFG---GFLAAWMIPhf 175
Cdd:cd17358 81 CILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALG----SLNQLLVNIGillGYVLGSFLP-- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 176 gWRSVLMLGGVTPLLLGVLLLVkMPESVRFMVANSQpVDRIRATLAR-------ISRDA--LNAASFVMTETAPQTGSKG 246
Cdd:cd17358 155 -WRTLALIGAIPPVVFLILLFF-IPESPRWLAKKGR-EEEAEKSLQFlrgkdadISKEAaeIQEELAELEKEAKESSFSD 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 979579332 247 -IGVVLSRSYVVGSVMLWLAYFMGL--VIFYASinwmpILLKEAGLT--PKSATLISALFPLggVGAVLCGVLMDR 317
Cdd:cd17358 232 lFQRKYLKPLVIGLGLMLFQQLSGInaVIFYAS-----SIFDEAGSGldPNTATIIIGVVQV--VGTLVATLLVDR 300
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
34-205 |
3.46e-09 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 58.52 E-value: 3.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 34 LLDGFDTAAIG----FIAPSLL--TEWH-LTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVS 106
Cdd:cd17362 7 LLFGYDIGATSgallSITSPALsgTDWYnLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVT 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 107 AFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLA-AWMIPHFGWRsvLMLG- 184
Cdd:cd17362 87 GLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGyAFADVVGGWR--YMYGl 164
|
170 180
....*....|....*....|.
gi 979579332 185 GVTPLLLGVLLLVKMPESVRF 205
Cdd:cd17362 165 AAPPALLLGIGMWFLPPSPRW 185
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
24-178 |
5.73e-09 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 58.16 E-value: 5.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 24 LVFLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAAC 103
Cdd:TIGR00711 2 LLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 979579332 104 FVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWR 178
Cdd:TIGR00711 82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWR 156
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
66-180 |
1.54e-08 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 56.87 E-value: 1.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 66 SAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLGAAmPNAVTMMGEFCPDKR 145
Cdd:cd06179 39 TAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQ-GLGAAVASELVPNKY 117
|
90 100 110
....*....|....*....|....*....|....*..
gi 979579332 146 RATVINLMFCGFPLGAAFGGFLAAWMI--PHFGWRSV 180
Cdd:cd06179 118 RGLVQGVVNLVASPGSALGPLIAGALVeaNAAGWRWI 154
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
47-431 |
1.56e-08 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 56.48 E-value: 1.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 47 APSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQ----LTVLRFVT 122
Cdd:cd17345 26 QPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSATSsvglMFILLFLN 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 123 GVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFG---WRSVLMLGGVTPLLLGVLLLVKM 199
Cdd:cd17345 106 GWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGdgwWRGAFIFPAIIAIIVAVIVLFLG 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 200 ---PESVRFmvansQPVDRIRATLARISRDALNAASFVMTEtapqtgskgigvvLSRSYVVGSVMLWLAYFMGLVIF--- 273
Cdd:cd17345 186 kdtPESEGL-----PPIEEYKGDYPEEADGEEEEQELSAWE-------------IFVKYVLKNKLLWYIAIANVFVYlvr 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 274 YASINWMPILLKEA-GLTPKSATLISALFPLGGV-GAVLCGVLMDR-FNANRVIAVCYALTAVSVYAIG-QAVGNVGLLV 349
Cdd:cd17345 248 YGILDWAPTYLSEVkGFSKAQAMWAFSLFEWAAIpGTLLAGWLSDKlFKGRRAPTGIIFMILVIVALIVyWLAPNVLVDL 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 350 LIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGGIAGSFLVAELTRRHFTFAGVFATIAVAGVLSCVAL 429
Cdd:cd17345 328 IALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGSVLATALIGIIVDHFGWNGGFIVLLASCILAIIFL 407
|
..
gi 979579332 430 LI 431
Cdd:cd17345 408 AL 409
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
27-170 |
3.14e-08 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 55.33 E-value: 3.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 27 LMCFVIVL---LDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGL---------ACGALVSGPLSDRLGRRALLLG 94
Cdd:cd17356 1 LLCAFVSLggfLFGYDTGSISGILNMKSFQKYFADNTGTYYPSSSRQGLivsivnlgsFFGALISSFLSDRIGRKKSIQI 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 979579332 95 SVFLF--GAACFVSAFSSgIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLmfcgFPLGAAFGGFLAAW 170
Cdd:cd17356 81 GCVIYiiGAIIQVAAIGK-WYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSL----YQLAITIGILVAYC 153
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
48-425 |
3.72e-08 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 55.27 E-value: 3.72e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 48 PSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLG 127
Cdd:cd17503 20 PTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 128 AAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSVlmlggvtplllgvlllvkmpesvrFMV 207
Cdd:cd17503 100 VLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWI------------------------FYI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 208 anSQPVDRIRATLARISRdalnaasfvmtetapqtgskgIGVVLSRSYVVGSVMLWLAYFmglvIFYASINWMPILLKE- 286
Cdd:cd17503 156 --NLPIGILALLLAPLLD---------------------LRLFKDRNFTLGLLLSFLLGL----GLFGAMFLLPLYLQNv 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 287 AGLTPKSATLISALFPLG-GVGAVLCGVLMDRFNANRVIAVCYALTAVSVYAIGQAVGNVGLLVLIV--FVAGVLMNTAQ 363
Cdd:cd17503 209 LGYSAFESGLVLAPGGLAsAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILplFIRGLGMGLVF 288
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 979579332 364 SSMPALAAAFYPTEGRGTGVAwMLGVGRF--GGIAGSFLVAELTRRHFTFAGVFATIAVAGVLS 425
Cdd:cd17503 289 MPLNTLALNSLPPEQIGDATA-LFNTIRQlgGSIGTALLATLLTNRTQFHHSRLSELLAQQVQK 351
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
260-431 |
4.23e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 54.98 E-value: 4.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 260 VMLWLAYFMGLVIFYASINWMPILLKEAGLTPKSATLISALFPLG-GVGAVLCGVLMDRFNANRVIAVCYALTAVSVYAI 338
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGaALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 339 GQAvGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGGIAGSFLVAELTrRHFTFAGVFATI 418
Cdd:COG2814 93 ALA-PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA-DLFGWRWVFLVN 170
|
170
....*....|...
gi 979579332 419 AVAGVLSCVALLI 431
Cdd:COG2814 171 AVLALLALLLLLR 183
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
64-204 |
9.49e-08 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 53.81 E-value: 9.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 64 VLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPD 143
Cdd:cd17360 40 IVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPP 119
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 979579332 144 KRRA--TVINLMFCgfpLGAAFGGFLAAWMIPHF--GWRSVLMLGGVtPLLLGVLLLVKMPESVR 204
Cdd:cd17360 120 RIRGrlVTINVLFI---TGGQFVAYVINGAFSYLpgGWRWMLGLAAV-PAVLQFIGLLFLPESPR 180
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
64-429 |
1.05e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 53.72 E-value: 1.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 64 VLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPD 143
Cdd:cd17477 36 VASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATN 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 144 KRRATVINLMFCGFPLGAAFGGFLAAWMIPH----FGWRSVLMLGGVTPLLLGVLLLVKMPEsvrfmvansqPVDRIRAT 219
Cdd:cd17477 116 ENRGRVLGLYSTVLGLGFALGPLLLALVGTAgalpFLIAAVLLLLALVPLLLTRRAAPEIEE----------AESISLRR 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 220 LARISRDALNAAsfvmtetapqtgskgigvvlsrsyvvgsvmlwLAYFMGLVIFYASinwMPILLKEAGLTPKSATLISA 299
Cdd:cd17477 186 LLRIAPLALLGA--------------------------------FVAGFLEGAFYSL---LPLYGLRLGLSVAQAALLLA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 300 LFPLGG-VGAVLCGVLMDRFNANRVIAVCYALTAVSVYAIGQAVGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEG 378
Cdd:cd17477 231 AFVLGGlLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDE 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 979579332 379 RGTGVAWMLGVGRFGGIAGSFLVAeLTRRHFTFAGVFATIAVAGVLSCVAL 429
Cdd:cd17477 311 LVAANAALLLLYGLGSVIGPLLAG-ALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
21-162 |
1.14e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 53.44 E-value: 1.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 21 FQWLVFLMCFVIVLLDGFDTAAIGFIAPSLLTE-WHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLF 99
Cdd:COG2814 204 LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL 283
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 979579332 100 GAACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAA 162
Cdd:COG2814 284 ALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
23-187 |
1.23e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 53.32 E-value: 1.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 23 WLVFLMCFVIvlldgfdtaAIGFIAPSLLTeWHLTKPDLAPVLSAALFGL-----ACGALVSGPLSDRLGRRALLLGSVF 97
Cdd:cd17370 203 WLYLLAVALF---------ALGNFSFAFLI-LRAQELGLSAALIPLLYALfnlvyALAAYPAGRLSDRIGRKKLLILGYL 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 98 LFGAACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGW 177
Cdd:cd17370 273 SLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISP 352
|
170
....*....|
gi 979579332 178 RSVLMLGGVT 187
Cdd:cd17370 353 SAAFLFSAVL 362
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
17-186 |
1.34e-07 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 53.59 E-value: 1.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 17 PFGGFQWLVFLMCFVIVlldGFDTA---AIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLL 93
Cdd:TIGR00892 12 PDGGWGWVVLGATFVSI---GFSYAfpkAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 94 GSVFLFGAACFVSAFSSGIEQLTV-LRFVTGVGLGAAMPNAVTMMGEFCpDKRRATVINLMFCGFPLGAAFGGFLAAWMI 172
Cdd:TIGR00892 89 AGGLLASLGMILASFSSNVIELYLtAGFITGLGLAFNFQPSLTMLGKYF-YRRRPLANGLAMAGSPVFLSTLAPLNQYLF 167
|
170
....*....|....*
gi 979579332 173 PHFGWR-SVLMLGGV 186
Cdd:TIGR00892 168 ESFGWRgSFLILGGL 182
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
49-177 |
2.01e-07 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 52.80 E-value: 2.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 49 SLLTEW-----HLTKPDLAPvlSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTG 123
Cdd:cd17446 20 TIITEWdlvcnHRALRQLAQ--SIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTG 97
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 979579332 124 VGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLaAWMIPHFGW 177
Cdd:cd17446 98 MALSGIVLNSVSLNVEWMPTRVRAVVGTLLGYCYTLGQLILAGV-AYAIRDWRW 150
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
22-186 |
2.08e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 52.62 E-value: 2.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 22 QWLVFLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGA 101
Cdd:cd06173 207 SPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 102 ACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSVL 181
Cdd:cd06173 287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVF 366
|
....*
gi 979579332 182 MLGGV 186
Cdd:cd06173 367 LLAGA 371
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
48-430 |
2.39e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 52.56 E-value: 2.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 48 PSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLG 127
Cdd:cd17478 20 PLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 128 AAMPNAVTMMGEFcPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFG---WRSVLMLGGVTPLLLGVLllvkmpesVR 204
Cdd:cd17478 100 AFHPEGARLASQA-AGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGglgLLILLIIPGLAVALLLLR--------LR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 205 FMVANSQPVDRIRATLARISRDALNAASFVMtetapqtgskgiGVVLSRSyvvgsvmlwlAYFMGLVIFyasinwMPILL 284
Cdd:cd17478 171 PLKKPEAKKAAAKSSARSTLKGVWRALLLLL------------IIVFLRS----------WVLSSLTTF------LPFYL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 285 KEAGLTPKSATLISALFPLGG-VGAVLCGVLMDRFNANRVIAVCYALTAVSVYAIGQAVGNvgLLVLIVFVAGVLMNTAQ 363
Cdd:cd17478 223 VQRGYSLVFAGLLLSLFLFAGaIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGI--WSYILLVLAGFLLFASF 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 979579332 364 SSMPALAAAFYPtEGRGTGVAWMLGVGRFGGIAGSFLVAELTrRHFTFAGVFATIAVAGVLSCVALL 430
Cdd:cd17478 301 PVTVVLAQELLP-GNVGLASGLMMGLSFGLGGIGAPVLGALA-DAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
30-178 |
4.44e-07 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 51.88 E-value: 4.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 30 FVIVLLDGFDTAAIG---FIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVS 106
Cdd:cd17476 1 ATISGAQLLNQAGLGsviVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 979579332 107 AFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGE-FCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWR 178
Cdd:cd17476 81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRtYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWP 153
|
|
| MFS_SVOPL |
cd17442 |
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ... |
24-178 |
4.80e-07 |
|
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 51.73 E-value: 4.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 24 LVFLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSvFLFGAA- 102
Cdd:cd17442 1 LLFLIMGSTGVAEAMEIMLLAVVSPEIRCEWHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLS-FVWGAYf 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 979579332 103 CFVSAFSSGIEQLTVLRFVTGVGLgAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWR 178
Cdd:cd17442 80 SLLTSFAPSYIWFVFLRCMVGCGV-SGHSQGLIIKTEFLPTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLGWR 154
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
23-183 |
4.86e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 51.40 E-value: 4.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 23 WLVFLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAA 102
Cdd:cd17478 194 WRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPF 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 103 CFVSAFSSGIeQLTVLRFVTGVGLGAAMPNAVTMMGEFCPdkRRATVINLMFCGFPLG-AAFGGFLAAWMIPHFGWRSVL 181
Cdd:cd17478 274 LLLFLLTPGI-WSYILLVLAGFLLFASFPVTVVLAQELLP--GNVGLASGLMMGLSFGlGGIGAPVLGALADAFGLESVL 350
|
..
gi 979579332 182 ML 183
Cdd:cd17478 351 LI 352
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
3-186 |
4.89e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 51.44 E-value: 4.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 3 RTPVVNVQTFINEQPFGGFQWLVFLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLAcgALVSGPL 82
Cdd:cd17489 173 PPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVYAIALLLS--RPFSGKL 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 83 SDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAA 162
Cdd:cd17489 251 SDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIG 330
|
170 180
....*....|....*....|....
gi 979579332 163 FGGFLAAWMIPHFGWRSVLMLGGV 186
Cdd:cd17489 331 LGGLLLGLVAELFGYRAMFLLAAV 354
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
262-437 |
5.13e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 51.26 E-value: 5.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 262 LWLAYFMGLVIFYASINWMPILLKEA-GLTPKSATLISALFPLG-GVGAVLCGVLMDRFNANRVIAVCYALTAVSVYAIG 339
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLLLTLFSLGyALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 340 qAVGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGGIAGSFLVAELTrRHFTFAGVFATIA 419
Cdd:pfam07690 81 -FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA-SLFGWRAAFLILA 158
|
170
....*....|....*...
gi 979579332 420 VAGVLSCVALLIKQTARP 437
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPE 176
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
21-424 |
6.72e-07 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 51.10 E-value: 6.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 21 FQWLVFLMCFVIvlldgfdTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLG-RRALLLGSVFLF 99
Cdd:cd17341 3 LSWLSFFLGFMV-------WFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGgRRVFIASLLLLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 100 GAACFVSAFSSGIEQLTVLRFVTGVGlGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMI------- 172
Cdd:cd17341 76 IPLLALALAVSSYWGLLVLGFLLGFA-GANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAgaivfdg 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 173 PHFGWRSVLMLGGVtplllgvlllvkmpesvrfmvansqpvdrIRATLArisrdalnAASFVMTETAPQTGSKGIGVVLS 252
Cdd:cd17341 155 GFVGWRNAFFVPGI-----------------------------LLAIAA--------VLVLLFGDDLPTGKASALEFLKV 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 253 RSYVVGSVMLW---LAYFMGLVIFYASINWMPILLKEA-GLTPKSATLISALFPL-GGVGAVLCGVLMDRFNANRVIAVC 327
Cdd:cd17341 198 QLAVLKNYRTWilsLLYGVTFGSFVGFSNVLPTYFKTRfGLPLVTAGILAALFPLaGALARPAGGWLSDRFGGRRRLWWL 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 328 YALTAVSVYAIG----QAVGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPtegRGTGVA--WMLGVGRFGGIAGSFLV 401
Cdd:cd17341 278 FIVMTIGAALLSlslpTSGTNLVLFLALFVALGLGAGAGNGSVFRMVPFIFR---RELGAVtgLVGAIGGLGGFFLPLLF 354
|
410 420
....*....|....*....|...
gi 979579332 402 AELTRRHFTFAGVFATIAVAGVL 424
Cdd:cd17341 355 GSSALMTGSGVGAFSLFGVLAVA 377
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
26-180 |
6.97e-07 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 51.18 E-value: 6.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 26 FLMC-FVIVLL--DGFDTAAIGFiaPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAA 102
Cdd:PRK10473 4 FLLCsFALVLLypAGIDMYLVGL--PRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 103 CFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATV---INLMFCGFPLGAAFGGFLaawMIPHFGWRS 179
Cdd:PRK10473 82 SLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVlslLNGITCIIPVLAPVLGHL---IMLKFPWQS 158
|
.
gi 979579332 180 V 180
Cdd:PRK10473 159 L 159
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
64-431 |
7.51e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.07 E-value: 7.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 64 VLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPD 143
Cdd:cd17329 40 VLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 144 KRRATVINLMFCGFPLGAAFGGFLAAWMIpHFGWRSVLMLGGVTPLLLGVLLLVKMPESVRFMVAnsQPVDRIRATLARI 223
Cdd:cd17329 120 ENRTRAFSLLYWAINLGVAIGPLLGGLLL-LYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRA--AEKTEILRGYKIV 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 224 SRDalnaASFVMtetapqtgskgigvvlsrsYVVGSVMLWLAYFMGLVIfyasinwMPILLKEAGLTPksATLISALFPL 303
Cdd:cd17329 197 LRD----RAFLL-------------------FLLASFLISLIYFQLEST-------LPVYVVEILGLG--ESLLGLLLAL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 304 GGVGAVLCGV----LMDRFNANRVIAVCYALTAVSvYAIGQAVGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEGR 379
Cdd:cd17329 245 NALLIVLLQFpvarLVERFRLRKILMIGILLFAIG-FAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKR 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 979579332 380 GT---GVAWMLGVGR-FGGIAGSFLVAeltrrHFTFAGVFATIAVAGVLSCVALLI 431
Cdd:cd17329 324 GSymgFYALAWGLGRaIGPLVGGLLLD-----LLGPGLPWLILAALGLIAAALLLG 374
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
13-205 |
1.76e-06 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 50.11 E-value: 1.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 13 INEQPFGGFQWLVFLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLA-----CGALVSGPLSDRLG 87
Cdd:TIGR00887 5 ADTAPFGWQHFRAIVIAGVGFFTDSYDLFCISLVTKMLGYVYYHGKGPLPSSVSAAVNGSAsigtlAGQLFFGWLADKLG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 88 RRALLLGSVFLFGAACFVSAFSSGIEQLTVL------RFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFC--GF-P 158
Cdd:TIGR00887 85 RKRVYGMELIIMIIATVASGLSPGSSPKSVMatlcfwRFWLGVGIGGDYPLSAIITSEFATKKWRGAMMAAVFAmqGFgI 164
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 979579332 159 LGAAF------GGFLAAWMIPHFG--------------WRSVLMLGGVtPLLLGVLLLVKMPESVRF 205
Cdd:TIGR00887 165 LAGAIvalivlAGFKHSLEAAADEasctgscvpavdymWRILIGFGAV-PALLALYFRLTIPETPRY 230
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
22-183 |
1.79e-06 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 50.11 E-value: 1.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 22 QWLVFLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLG-RRALLLGSVfLFG 100
Cdd:PRK14995 4 QWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGfKRLLMLGGT-LFG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 101 AACFVSAFSSGIEQLTVLRFVtgVGLGAAMPNAVTMMG---EFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGW 177
Cdd:PRK14995 83 LASLAAAFSPTASWLIATRAL--LAIGAAMIVPATLAGiraTFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYW 160
|
....*.
gi 979579332 178 RSVLML 183
Cdd:PRK14995 161 GSVFLI 166
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
280-448 |
5.73e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 48.31 E-value: 5.73e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 280 MPILLKEAGLTPKSATLISALFPLG-GVGAVLCGVLMDRFNANRVIAVCYALTAVSVYAIGQAvGNVGLLVLIVFVAGVL 358
Cdd:COG0738 31 IPALKDAFGLSDAQAGLLLFAFFLGyLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALA-PSYPLLLLALFLLGLG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 359 MNTAQSSMPALAAAFYPtEGRGTGVAWMLGVGRFGGIAGSFLVAELTRRHFTFAGVFATIAVAGVLSCVALLIKQTARPY 438
Cdd:COG0738 110 LGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPE 188
|
170
....*....|
gi 979579332 439 EAAPSSGNAE 448
Cdd:COG0738 189 IEEEEEEAAG 198
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
37-436 |
8.50e-06 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 47.68 E-value: 8.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 37 GFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLT 116
Cdd:cd06180 12 GIGRFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 117 VLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPH-FGWRSVLMLGGVTPLLLGVll 195
Cdd:cd06180 92 ALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGgLSWRAGWLALALLSAVLLL-- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 196 lvkmpesvrfmvansqpvdrIRATLARISRDALNAASfvmtetapqtgskgigVVLSRSYVVGSVM-LWLAYFMGLVIFY 274
Cdd:cd06180 170 --------------------LSFLLLRRGPSAPTEAS----------------AAESAPGLNRPLWrLALAYGLFGFGYI 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 275 ASINWMPILLKEAGLTPKSATLISALFPLGGV-GAVLCGVLMDRFNANRVIAVCYALTAVSVYAIGQAVGNVGLLVLIVF 353
Cdd:cd06180 214 ITATFLPLIARETGAGSLLAGLLWSLFGLAAVpSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 354 VAGVLMNTAQSSMPalAAAFYPTEGRGTGVAWMLGVGRFGGIAGSFLVAELTRRHftfAGVFATIAVAGVLSCVALLIKQ 433
Cdd:cd06180 294 FGGTFMAITALVMA--LARELAPPAAPRALALMTASFGVGQILGPLLAGWLADAT---GGFAPALILAAAALVVAALLAL 368
|
...
gi 979579332 434 TAR 436
Cdd:cd06180 369 LVL 371
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
23-398 |
9.94e-06 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 47.63 E-value: 9.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 23 WLVFLMCFVIVLLDGFDTAAIGFIAPS-LLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGA 101
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNAAVMgMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 102 ACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPH------F 175
Cdd:cd17327 84 LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKIlgvgglA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 176 GWRSV-LMLGGVT--PLLLGVLLLVKMPESVRFMVAN--SQPVDRIRAtlarisrdalNAASFVMTETAPQTGSKgigvv 250
Cdd:cd17327 164 GWRWLfIIEGLITiiIGLVIFFWLPDNPSKAWFLTEEekELAVERLRA----------NQTGKGDQKFKWKQIKE----- 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 251 lsrsyVVGSVMLWLAYFMGLVIF---YASINWMPILLKEAGLTPKSATLIS-ALFPLGGVGAVLCGVLMDRFNANRVIAV 326
Cdd:cd17327 229 -----AFKDPRTWLLFLFFFCSQitnNGISNFLPLILKSLGFYSLQTNLLSvPIGALGAVSLLIAALLSDRFKKRGLFAI 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 979579332 327 ---CYALTAVSVY-AIGQAVGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYpteGRGTGVAWMLGVGRFGGIAGS 398
Cdd:cd17327 304 facVLALVGSIILlAAPNPPGAYFAAYILGGGSYAGFPILLSWISSNCAGYT---KRATVLAIMLIFYNVGNIVAP 376
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
80-204 |
1.03e-05 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 47.51 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 80 GPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLG-AAMPNAVTMMGEFcpDKRRATVINLMFCGFP 158
Cdd:PRK15403 72 GPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICfIATVGYVTVQEAF--GQTKGIKLMAIITSIV 149
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 979579332 159 LGAAFGGFLAAWMIPHF-GWRSVLMLGGVTPLLLGVLLLVKMPESVR 204
Cdd:PRK15403 150 LVAPIIGPLSGAALMHFvHWKVLFAIIAVMGLIAFVGLLLAMPETVK 196
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
23-186 |
2.04e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 46.65 E-value: 2.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 23 WLVFLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDR-LGRRALLLGSVFLFGA 101
Cdd:cd06174 203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMAL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 102 ACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIP-HFGWRSV 180
Cdd:cd06174 283 GLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGA 362
|
....*.
gi 979579332 181 LMLGGV 186
Cdd:cd06174 363 FLVLAV 368
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
64-180 |
2.06e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 46.49 E-value: 2.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 64 VLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPD 143
Cdd:cd17391 245 VFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPK 324
|
90 100 110
....*....|....*....|....*....|....*....
gi 979579332 144 --KRRATVINLMFcgFPLGAAFGGFLAAWMIPHFGWRSV 180
Cdd:cd17391 325 evAGRIFGYNQSF--QYLGNVAGPLLGSAIAAHFGYRAV 361
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
64-222 |
3.04e-05 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 46.10 E-value: 3.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 64 VLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAAC---FVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEF 140
Cdd:cd17357 54 IVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSllmFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEI 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 141 CPDKRRATVINLMFCGFPLGAAFGGFLAAWMIphFG----WRsVLMLGGVTPLLLGVLLLVKMPESVRFMVANSQPVDRI 216
Cdd:cd17357 134 SPSELRGALGSLTQIGVTLGILLGQVFGLPSV--LGtetlWP-YLLFFPGIPALLQLAALPFFPESPKFLLISKGDEEEA 210
|
....*.
gi 979579332 217 RATLAR 222
Cdd:cd17357 211 EKSLKF 216
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
26-164 |
3.07e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.87 E-value: 3.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 26 FLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFV 105
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALG 281
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 979579332 106 SAFSSGIEQLTVLR---FVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFG 164
Cdd:pfam07690 282 LLLLSLTLSSLWLLlalLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
64-180 |
3.15e-05 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 46.05 E-value: 3.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 64 VLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGE--FC 141
Cdd:PRK11652 48 VMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDlyEG 127
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 979579332 142 PDKRRA-TVINLMFCGFPLGAAF-GGFLAAWmiphFGWRSV 180
Cdd:PRK11652 128 TQLRHAnSLLNMGILVSPLLAPLiGGLLTTL----FGWRAC 164
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
26-179 |
3.99e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.66 E-value: 3.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 26 FLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLA-CGALVSGPLSDRLGRRALLLGSVFLFGAACF 104
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAAlLGAPLWPRLAKRFGKKKAFIIGLLLAALGLL 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 105 VSAFS--SGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVIN---LMFCGFP----LGAAFGGFLAAWMIPHF 175
Cdd:COG2211 310 LLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRregLYFGIFTfaikLGQALAGALAGLLLALF 389
|
....
gi 979579332 176 GWRS 179
Cdd:COG2211 390 GYVA 393
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
49-170 |
4.39e-05 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 45.54 E-value: 4.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 49 SLLTEWHLTKPDLAPV-LSAALF--GLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVG 125
Cdd:cd17377 26 SIVSEWFLVGNAAYKVsLASSFFfaGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVM 105
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 979579332 126 LGAAMPNAVTMMGEFCPDKRRA---TVINLMFC-GFPLGAAFGGFLAAW 170
Cdd:cd17377 106 NGGMSLVAFVLLNECVGKSYWAlagSLGGLFFAvGIAQYALLGYFIRSW 154
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
29-172 |
4.91e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 45.39 E-value: 4.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 29 CFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAF 108
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 979579332 109 SSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPdKRRATVINLMFCGFPLGAAFGGFLAAWMI 172
Cdd:cd17333 81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATSLL 143
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
64-431 |
9.15e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.53 E-value: 9.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 64 VLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLT-----VLRFVTGVGLGAAMPNAVTMMG 138
Cdd:cd06173 39 VLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSlwlllVLAFLLGIASAFFGPARQALLP 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 139 EFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSVLMLGGVTPLLLGVlllvkmpeSVRFMvansqpvdRIRA 218
Cdd:cd06173 119 ELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSAL--------LLLFI--------RRPP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 219 TLARISRDALNAASFvmtetapqtgsKGIGVVLSRSYVVGSVMLWLAYFMGLVIFYASInwMPILLKEA-GLTPKSATLI 297
Cdd:cd06173 183 PAAPGESSSLLLRDL-----------REGLRYLRRSPLLRLLLLALALFALLGGALTVL--LPLLAKEVlGGGAAGYGLL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 298 SALFPLGG-VGAVLCGVLMDRFNANRVIAVCYALTAVSVYAIGqAVGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPT 376
Cdd:cd06173 250 LAAFGVGAlLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLG-LSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPD 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 979579332 377 EGRGTGVAWMLGVGRFGGIAGSFLVAELtrrhFTFAGVFATIAVAGVLSCVALLI 431
Cdd:cd06173 329 ELRGRVFSVYNALNSGAMPLGALLAGLL----ADALGLSAVFLLAGALLLLAALL 379
|
|
| MFS_SLC22A4_5_OCTN1_2 |
cd17376 |
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ... |
35-125 |
1.00e-04 |
|
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340934 [Multi-domain] Cd Length: 342 Bit Score: 44.38 E-value: 1.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 35 LDGFDTAAiGFIAPSLLTEWHLTKPD--LAPVLSAALF-GLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSG 111
Cdd:cd17376 9 LDGWEYSQ-DVYLSTIVTEWNLVCEDdwKVPLTTSLFFvGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSPS 87
|
90
....*....|....
gi 979579332 112 IEQLTVLRFVTGVG 125
Cdd:cd17376 88 WEMFTVLFVIVGMG 101
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
68-149 |
1.44e-04 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 44.14 E-value: 1.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 68 ALFGLAcGALVSGPLSDRLGRR-ALLLGSVFLFGAA--CFVSAFSSGIEQLTVLRFVTGVGLGAAMpNAVTM-MGEFCPD 143
Cdd:cd17432 60 PLGGLF-GSLLVGPLVIRLGRKgTLLLNNIFAIVAAilMGLSKIAKSFEMIIVGRFLVGINAGISL-NVVPMyLGESAPK 137
|
....*.
gi 979579332 144 KRRATV 149
Cdd:cd17432 138 NLRGAV 143
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
34-216 |
1.55e-04 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 43.63 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 34 LLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIE 113
Cdd:cd17435 11 LLVGYELGIISGALLQLRTLLALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYT 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 114 QLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFgGFLAAWM---IPHfGWRsvLMLGGVTPLL 190
Cdd:cd17435 91 VLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILL-AYISNYAfanVSN-GWK--YMFGLVIPLA 166
|
170 180
....*....|....*....|....*..
gi 979579332 191 LGVLLLVK-MPESVRFMVANSQPVDRI 216
Cdd:cd17435 167 ALQAIAMYfLPPSPRFLVMKDNMRARL 193
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
270-424 |
1.56e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 43.69 E-value: 1.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 270 LVIFYASINWMPILLKEAGLTPKSATLISALFPL-GGVGAVLCGVLMDRFNANRVIAVCYaLTAVSVYAIGQAVGNVGLL 348
Cdd:cd17370 212 FALGNFSFAFLILRAQELGLSAALIPLLYALFNLvYALAAYPAGRLSDRIGRKKLLILGY-LSLALAYLGFALGSSLWLL 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 349 VLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWMLGVGRFGGIAGSFLVAELTRRH-----FTFAGVFATIAVAGV 423
Cdd:cd17370 291 LLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLIspsaaFLFSAVLALIALLLL 370
|
.
gi 979579332 424 L 424
Cdd:cd17370 371 L 371
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
46-182 |
1.98e-04 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 43.51 E-value: 1.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 46 IAPSLLTEWHLTKPDLAPVLSAALFGLACGALV--SGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTG 123
Cdd:pfam06779 15 ILPVMIAEGQFSLSQAGLLAAANYAGYLAGALLasFAWRHGASRLRPALLAGLLATVLLLLAMAATSSFWAVLLIRFLAG 94
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 979579332 124 VGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGfLAAWMIPHFGWRSVLM 182
Cdd:pfam06779 95 VASAAVMIFGSSLILGHATAARRAFVGALLFAGVGIGIALSG-LLVPLGLQLGLGGSSL 152
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
75-205 |
1.99e-04 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 43.54 E-value: 1.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 75 GALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATV----- 149
Cdd:cd17437 48 GSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLtsfpe 127
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 150 --INL-MFCGFPLGAAFGGFLAawmipHFGWRsvLMLG-GVTPLLLGVLLLVKMPESVRF 205
Cdd:cd17437 128 ifINIgILLGYVSNYAFSGLPL-----HVGWR--LMLGvGAVPSLFLAIGVLAMPESPRW 180
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
262-431 |
2.25e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 43.35 E-value: 2.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 262 LWLAYFMGLVIFYASINWMPILLKEAGLTPKSATLISALFPLGGVGA-VLCGVLMDRFNANRVIAVCYALTAVSVYAIGQ 340
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLArPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 341 AvGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAWMlGVGRFGGIAGSFLVAELTRRHFTFAGVFATIAV 420
Cdd:cd17489 81 A-TSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYY-GLATTLAMALGPALGLFLYQHLGFAVLFIVAAV 158
|
170
....*....|.
gi 979579332 421 AGVLSCVALLI 431
Cdd:cd17489 159 LALLALLLVFL 169
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
76-433 |
3.04e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 43.02 E-value: 3.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 76 ALVS---GPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVgLGAAMPNAVTMMGEFCPDKRRATVINL 152
Cdd:cd17391 50 AIFSpiwGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGV-FSGYVPNATALIASQTPKEKSGWALGT 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 153 MFCGFPLGAAFGGFLAAWMIPHFGWRSVLMLGGVTPLLLGVLllvkmpeSVRFMVANSQPVDRIRAT-----LARISRDA 227
Cdd:cd17391 129 LSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLL-------TLFFVKEDFKPVEKKKMVstkevWNSVPNPS 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 228 LNAASFVMTETApQTGSKGIGVVLSRsYV--VGSVMLWLAYFMGLVIfyasinwmpillkeagltpkSATLISALfplgg 305
Cdd:cd17391 202 LLISLFVTTFII-QLANQSIEPILTL-YIrqLMGDASNLAFISGLVF--------------------SATGVSSL----- 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 306 VGAVLCGVLMDRFNANRVIAVCyALTAVSVYAIGQAVGNVGLLVLIVFVAGVLMNTAQSSMPALAAAFYPTEGRGTGVAW 385
Cdd:cd17391 255 LSAPRLGKLGDRIGHHRILLGA-LLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGY 333
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 979579332 386 MLGVGRFGGIAGSFLVAELTrRHFTFAGVFATIAVAGVLSCVALLIKQ 433
Cdd:cd17391 334 NQSFQYLGNVAGPLLGSAIA-AHFGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
22-176 |
6.36e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 41.82 E-value: 6.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 22 QWLVFLMCFVIVLLDGFDTAAIGFIapsLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGA 101
Cdd:cd17332 222 PFLILLLAYLLYFLAFNIVNTVLVY---YFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAIL 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 102 ACFVSAFSSGIEQ--LTVLRFVTGVGLGAAMPNAVTMM------GEFCPDKRRATVIN-LMFCGFPLGAAFGGFLAAWMI 172
Cdd:cd17332 299 GLLLLFFLPPGNLvlILVLAVLAGIGYGGANLLPWAMLadvidyGELKTGKRREGIFYsVMTFFRKLGLALAGALVGLIL 378
|
....
gi 979579332 173 PHFG 176
Cdd:cd17332 379 SLAG 382
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
27-169 |
7.51e-04 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 41.47 E-value: 7.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 27 LMCFVIVLLDgfdTAAIGFIAP---SLLTEWHLTKPDLAP--VLSAALFGLA--CGALVSGPLSDRLGRRALLLGSVFLF 99
Cdd:cd17388 2 IFILVTVLLD---AMGIGLIMPvlpTLLREFVGDSADAAThyGVLLALYALMqfIFAPILGALSDRFGRRPVLLLSLAGA 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 979579332 100 GAACFVSAFSSGIEQLTVLRFVTGVgLGAAMPNAVTMMGEFCPDKRRATVINLMFC----GFPLGAAFGGFLAA 169
Cdd:cd17388 79 ALDYLLMAFAPTLWWLYLGRIIAGI-TGATGAVAAAYIADVTPPEQRARNFGLLGAafglGFIAGPALGGLLGE 151
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
23-126 |
7.80e-04 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 41.84 E-value: 7.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 23 WLVFLMCFVIVlldgfdtaaigFIAPSLLTE----WHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFL 98
Cdd:PLN00028 42 WISFFTCFVST-----------FAAAPLLPIirdnLNLTKSDIGNAGIASVSGSIFSRLAMGPVCDLYGPRYGSAFLLML 110
|
90 100
....*....|....*....|....*...
gi 979579332 99 FGAACFVSAFSSGIEQLTVLRFVTGVGL 126
Cdd:PLN00028 111 TAPAVFCMSLVSSATGFIAVRFFIGFSL 138
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
42-201 |
8.47e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 41.52 E-value: 8.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 42 AIGFIAPSLLT-EWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLgsVFLFGAACFVSA---FSSGIEQLTV 117
Cdd:cd17371 227 GITTWLPSYLTgERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFA--LFALGSAISILLyffLPLSPTLILI 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 118 LRFVTGVGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSVLMLGGVTPLLLGVLLLV 197
Cdd:cd17371 305 LGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLAL 384
|
....
gi 979579332 198 KMPE 201
Cdd:cd17371 385 LLPE 388
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
30-186 |
9.59e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 41.44 E-value: 9.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 30 FVIVLLDGFDTAAIGFIAPSLLTE-WHLTKPDLAPVLS-AALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSA 107
Cdd:cd17331 213 LLVKLLSGLPIGMFQSMFSLVAMDfFGLTPEENGYLMSyAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLA 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 108 FSSGIEQLTVL-------RFVTGVGLGAAMPNAVtmmgefcPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSV 180
Cdd:cd17331 293 FVTTVWQLLVLllplvigGSVLYTVITSLLTKAV-------PPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPSF 365
|
....*.
gi 979579332 181 LMLGGV 186
Cdd:cd17331 366 GLLGAA 371
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
23-186 |
1.01e-03 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 41.34 E-value: 1.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 23 WLVFLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAA 102
Cdd:cd17427 2 WAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 103 CFVSAFSSGIEQLTV-LRFVTGVGLGAAMPNAVTMMGEFCPdKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWR-SV 180
Cdd:cd17427 82 MISASFCNSVMQLYLcIGVIGGLGLAFNLQPALTIIGKYFY-KKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRgSF 160
|
....*.
gi 979579332 181 LMLGGV 186
Cdd:cd17427 161 LILGGL 166
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
70-177 |
1.29e-03 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 40.80 E-value: 1.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 70 FGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRATV 149
Cdd:cd17379 44 LGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTV 123
|
90 100
....*....|....*....|....*....
gi 979579332 150 INLMFCGFPLG-AAFGGFlaAWMIPHFGW 177
Cdd:cd17379 124 GIVYQMFFTLGlLILPGI--AYFIPHWRW 150
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
274-360 |
1.76e-03 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 40.38 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 274 YASINWMPILL-KEAGLTPKSATLISALFPLGG-VGAVLCGVLMDRFNANRVIAVCYALTAVSVYAIGQAVGNVGLLVLI 351
Cdd:cd17344 228 YTFLYWLPLYIsNTAILSAKKAGDLSTLFDVGGiVGGILAGYISDYTGGRATTCAAMLILAAPMLFIYNYFGQVSMTTNI 307
|
90
....*....|.
gi 979579332 352 V--FVAGVLMN 360
Cdd:cd17344 308 VllIVCGLLVN 318
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
30-170 |
1.79e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 40.25 E-value: 1.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 30 FVIVLLDGFDTAAIGFIAPSLLTEWHltKPDLAPVLSAALFGL-ACGALVSGP----LSDRLGRRALLLGSVFLFGAACF 104
Cdd:cd17330 2 FLVVFLDALGFGIVFPVLPFYVREFN--KLGASGYYVGLLQSSySLGQFLASPlwgrLSDRYGRKPVLLLSLAGSAVSYV 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 105 VSAFSSGIEQLTVLRFVTGVgLGAAMPNAVTMMGEFCPDKRRATVINLMF----CGFPLGAAFGGFLAAW 170
Cdd:cd17330 80 LLGLSRNLWLLFLARFLDGL-TGGNVSVAQAYIADITDEEERAKAFGIISaafgLGFILGPALGGFLSTP 148
|
|
| MFS_SLC22A7_OAT2 |
cd17447 |
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ... |
49-126 |
1.96e-03 |
|
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 40.10 E-value: 1.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 49 SLLTEWHLT--KPDLAPVLSAALF-GLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVG 125
Cdd:cd17447 22 TIATEWDLVcdRKGLNQATATFFFaGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFA 101
|
.
gi 979579332 126 L 126
Cdd:cd17447 102 L 102
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
74-366 |
2.04e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 40.28 E-value: 2.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 74 CGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTgVGLgAAMPNAVTMMGEFCPDKRRATVINLM 153
Cdd:cd17331 50 VGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLPS-VFM-HAMQAAQMVVTDLTDPGERAAALGRL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 154 FCGFPLGAAFGGFLAAWMIPHFGWRSVLMLGGVTPLLLGVLLLVKMPESVRfmvansqpvdriRATLARISRDALNAASF 233
Cdd:cd17331 128 GLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSNTK------------SKREKEAKESASPPSVF 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 234 VMTETAPQTGSKGIGVVLSRSYVVGsvmlwlayfMGLVIFYASINwmPILLKEAGLTPKSATLISALFPLGG--VGAVLC 311
Cdd:cd17331 196 NLKEILRLLRLPGVAFLLLVKLLSG---------LPIGMFQSMFS--LVAMDFFGLTPEENGYLMSYAGVLGmvVQGLLV 264
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 979579332 312 GVLMDRFNANRVIAVCYALTAVSVYAIGQAVGNVGLLVLIVF--VAGVLMNTAQSSM 366
Cdd:cd17331 265 GPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPlvIGGSVLYTVITSL 321
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
54-186 |
5.88e-03 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 38.70 E-value: 5.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 54 WHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTV-LRFVTGVGLGAAMPN 132
Cdd:cd17426 33 FNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGAGLIAASFCNTVEGLYFcVGVVGGLGLAFNLNP 112
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 979579332 133 AVTMMGEFCPdKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWR-SVLMLGGV 186
Cdd:cd17426 113 ALTMIGKYFY-KKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRgSFLILGGL 166
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
69-186 |
6.37e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 38.74 E-value: 6.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 69 LFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRRAT 148
Cdd:cd17490 241 LPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRST 320
|
90 100 110
....*....|....*....|....*....|....*...
gi 979579332 149 VINLMFCGFPLGAAFGGFLAAWMIPHFGWRSVLMLGGV 186
Cdd:cd17490 321 AMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGV 358
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
80-424 |
6.44e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 38.74 E-value: 6.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 80 GPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLGAAMpnAVTMMGEFCPDKRRATVINLMfcGFPL 159
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAISSV--VMALLADLTREENRTKAMALI--GASI 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 160 GAAFG-GFLAAWMIP-HFGWRSVLMLGGVTPLLLGVLLLVKMPESVRFMVANSQPVDRIRATLARISRDALNAASFVmte 237
Cdd:cd17472 129 GIAFAiSMVLGPLLAaHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFI--- 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 238 tapqtgskgigvvlsrsyvvgsvmlwlAYFMGLVIFYAsinwMPILLKEAGLTPKSATLISALFPLGGVGAVLCGVLMD- 316
Cdd:cd17472 206 ---------------------------LHFVLMAFFYI----LPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAe 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 317 -RFNANRVIAVCYALTAVSVYAIGQAVGNVGLLV--LIVFVAGVlmNTAQSSMPALAAAFYPTEGRGT--GVAWMLG-VG 390
Cdd:cd17472 255 kKGKMKQVFVSSILLIAVGFLLLLFAATSLWLLIigLIIFFIGF--NLLEALLPSLVSKIAPKEYRGTamGIYNTSQfLG 332
|
330 340 350
....*....|....*....|....*....|....*
gi 979579332 391 RF-GGIAGSFLVaeltrRHFTFAGVFATIAVAGVL 424
Cdd:cd17472 333 SFlGGALGGLLW-----GLLGYSSVFLTILILALL 362
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
46-338 |
6.87e-03 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 38.54 E-value: 6.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 46 IAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLGRRALLLGSVFLF--GAACFvsAFSSGIEQLTVLRFVTG 123
Cdd:PRK10091 25 VLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCviGNAMF--TLSSSYLMLAIGRLVSG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 124 VGLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPLGAAFGGFLAAWMIPHFGWRSVLMLGGVTPLLLGVLLLVKMPesv 203
Cdd:PRK10091 103 FPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLIAVFNIAVLASIYFWVP--- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 204 rfmvansqpvdriratlarisrdalnaasfvMTETAPQTGSKGIGVVLSRS---YVVGSVMLWLAyfmGLVIFYASINwm 280
Cdd:PRK10091 180 -------------------------------DIRDEAKGGLREQFHFLRSPapwLIFAATMFGNA---GVFAWFSYIK-- 223
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 979579332 281 PILLKEAGLTPKSATLISALFPLGGV-GAVLCGVLMDRFNANRVIAVCYALTAVSVYAI 338
Cdd:PRK10091 224 PYMMFISGFSETSMTFIMMLVGLGMVlGNLLSGRLSGRYSPLRIAAVTDFIIVLALLML 282
|
|
| MFS_SLC22A17_like |
cd17373 |
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ... |
69-146 |
7.27e-03 |
|
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340931 [Multi-domain] Cd Length: 348 Bit Score: 38.27 E-value: 7.27e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 979579332 69 LFGLACGALVSGPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVGLGAAMPNAVTMMGEFCPDKRR 146
Cdd:cd17373 35 LLGLIFGYLILGCIADRFGRRPVLLFSLILILIFGLTVALAVSVTMFSTLRFLEGFCLAGIILTLYLLRLELCDPGKR 112
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
80-183 |
8.18e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 38.36 E-value: 8.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 80 GPLSDRLGRRALLLGSVFLFGAACFVSAFSSGIEQLTVLRFVTGVgLGAAMPNAVTMMGEFCPDKRRATVINLMFCGFPL 159
Cdd:PRK09874 75 GGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGL-LGGFVPNANALIATQVPRNKSGWALGTLSTGGVS 153
|
90 100
....*....|....*....|....
gi 979579332 160 GAAFGGFLAAWMIPHFGWRSVLML 183
Cdd:PRK09874 154 GALLGPLAGGLLADSYGLRPVFFI 177
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
23-402 |
8.91e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 38.34 E-value: 8.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 23 WLVFLMCFVIVLLDGFDTAAIGFIAPSLLTEWHLTKPDLAPVLSAALFGLACGALVSGPLSDRLG-----RRALLLGSVF 97
Cdd:COG2211 10 KEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 98 LFGAACFVSAFSSGIEQ------LTVLRFVTGVGLGAAMPNAVTMMGEFCPD-KRRATVINLMFCGFPLGAAFGGFLAAW 170
Cdd:COG2211 90 PLALSFVLLFTAPDLSPtgkliyALVTYLLLGLAYTLVNIPYSALGAELTPDyEERTRLSSWRFAFAGLGGLLASVLPPP 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 171 MIPHF------GWRSVLMLGGVTPLLLGVLLLVKMPESVrfmvansqPVDRIRATLARISRDALNAASFVMtetapqtgs 244
Cdd:COG2211 170 LVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERP--------VPEEEKVSLKESLKALLKNRPFLL--------- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 245 kgigvvlsrsYVVGSVMLWLAYFM--GLVIFYASINWmpillkeaGLTPKSATLISALFPLGG-VGAVLCGVLMDRFNAN 321
Cdd:COG2211 233 ----------LLLAYLLFFLALALvaALLLYYFKYVL--------GLSAALVGLLLALYFLAAlLGAPLWPRLAKRFGKK 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 979579332 322 RVIAVCYALTAVSVYAIGQAV-GNVGLLVLIVFVAGVLMNTAQSSMPALAA-----AFYPTEGRGTGV--AWMLGVGRFG 393
Cdd:COG2211 295 KAFIIGLLLAALGLLLLFFLGpGNLWLLLVLAALAGIGLGAILVLPWAMLAdvvdyDEWKTGRRREGLyfGIFTFAIKLG 374
|
....*....
gi 979579332 394 GIAGSFLVA 402
Cdd:COG2211 375 QALAGALAG 383
|
|
| |
