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Conserved domains on  [gi|980725790|gb|KWK97087|]
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TetR family transcriptional regulator [Burkholderia ubonensis]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 15841129)

TetR/AcrR family transcriptional regulator controls genes involved in a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.357.10
Gene Ontology:  GO:0003677|GO:0006355
PubMed:  23602932|24006471|15944459
SCOP:  4000333

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TetR_C_15 super family cl38975
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 110-219 4.43e-23

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. This entry represents the C-terminal domain found in a number of different TetR transcription regulator proteins including SlmA proteins found in E. coli. Unlike other TetR proteins, SlmA functions not as a transcription regulator but rather as an NO (nucleoid occlusion) factor. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain.


The actual alignment was detected with superfamily member pfam17928:

Pssm-ID: 476838  Cd Length: 113  Bit Score: 89.69  E-value: 4.43e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 980725790  110 DDLHGTLCRITDSYYRMFVDEPLMRDIWRATQADRALQALDEADGAFLAGLLTKRLREIAPDARDAQLSAFSELTMVLIA 189
Cdd:pfam17928   1 EGWWDALDRLIDRYAAMNRDEPVFRDLWFADQADPRLADIDADNNRALAARFARALAPLAPDGDGDELVRTAAVLMHLAD 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 980725790  190 AAVRYAIGLPPKAARQRLAMFKRTLPVDLA 219
Cdd:pfam17928  81 ALLRLAIALDPDEDDAIVDEAKRMLRRYLA 110
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
31-186 1.67e-10

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 57.60  E-value: 1.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 980725790  31 QQRSRERFERILACAAEVMVEKGCDAFRMSDIVERTGIAFGSLYQYFPDKTAVIGTLAERYnalgHECVRRDLSRMKRID 110
Cdd:COG1309    1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERL----LEELLAALEEALAAE 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 980725790 111 DLHGTLCRITDSYYRMFVDEPLMRDI--WRATQADRALQALDEADGAFLAGLLTKRLREIAPDARDAQLSAFSELTMV 186
Cdd:COG1309   77 DPRERLRALLRAYLEFLAENPALARLllAEAAELPELRAALRALLRRLRALLAELLRAGGLLADVDPDALARALLALL 154
 
Name Accession Description Interval E-value
TetR_C_22 pfam17928
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 110-219 4.43e-23

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present the TetR Transcriptional Repressor present in sco1712 proteins from Streptomyces coelicolo which act as a regulator of antibiotic production.


Pssm-ID: 465571  Cd Length: 113  Bit Score: 89.69  E-value: 4.43e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 980725790  110 DDLHGTLCRITDSYYRMFVDEPLMRDIWRATQADRALQALDEADGAFLAGLLTKRLREIAPDARDAQLSAFSELTMVLIA 189
Cdd:pfam17928   1 EGWWDALDRLIDRYAAMNRDEPVFRDLWFADQADPRLADIDADNNRALAARFARALAPLAPDGDGDELVRTAAVLMHLAD 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 980725790  190 AAVRYAIGLPPKAARQRLAMFKRTLPVDLA 219
Cdd:pfam17928  81 ALLRLAIALDPDEDDAIVDEAKRMLRRYLA 110
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
31-186 1.67e-10

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 57.60  E-value: 1.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 980725790  31 QQRSRERFERILACAAEVMVEKGCDAFRMSDIVERTGIAFGSLYQYFPDKTAVIGTLAERYnalgHECVRRDLSRMKRID 110
Cdd:COG1309    1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERL----LEELLAALEEALAAE 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 980725790 111 DLHGTLCRITDSYYRMFVDEPLMRDI--WRATQADRALQALDEADGAFLAGLLTKRLREIAPDARDAQLSAFSELTMV 186
Cdd:COG1309   77 DPRERLRALLRAYLEFLAENPALARLllAEAAELPELRAALRALLRRLRALLAELLRAGGLLADVDPDALARALLALL 154
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
41-84 5.62e-07

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 45.09  E-value: 5.62e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 980725790   41 ILACAAEVMVEKGCDAFRMSDIVERTGIAFGSLYQYFPDKTAVI 84
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELL 44
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
31-134 3.45e-04

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 40.27  E-value: 3.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 980725790  31 QQRSRERFERILACAAEVMVEKGCDAFRMSDIVERTGIAFGSLYQYFPDK----TAVIGTLAERYNALGHECVRRDLSRM 106
Cdd:NF041196   1 QERAIRTRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKealaRAVLEEQVARLREAVEPQRAGGGSKL 80

                         90       100
                 ....*....|....*....|....*...
gi 980725790 107 KriddlhgTLCRITDSYYRMFVDEPLMR 134
Cdd:NF041196  81 Q-------ELVDLTHVLARRLRTDPVVR 101
 
Name Accession Description Interval E-value
TetR_C_22 pfam17928
Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the ...
 110-219 4.43e-23

Tetracyclin repressor-like, C-terminal domain; TetR family regulators are involved in the transcriptional control of multidrug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The TetR proteins identified in overm ultiple genera of bacteria and archaea share a common helix-turn-helix (HTH) structure in their DNA-binding domain. However, TetR proteins can work in different ways: they can bind a target operator directly to exert their effect (e.g. TetR binds Tet(A) gene to repress it in the absence of tetracycline), or they can be involved in complex regulatory cascades in which the TetR protein can either be modulated by another regulator or TetR can trigger the cellular response. TetR regulates the expression of the membrane-associated tetracycline resistance protein, TetA, which exports the tetracycline antibiotic out of the cell before it can attach to the ribosomes and inhibit protein synthesis. TetR blocks transcription from the genes encoding both TetA and TetR in the absence of antibiotic. The C-terminal domain is multi-helical and is interlocked in the homodimer with the helix-turn-helix (HTH) DNA-binding domain. This entry represents the C-terminal domain present the TetR Transcriptional Repressor present in sco1712 proteins from Streptomyces coelicolo which act as a regulator of antibiotic production.


Pssm-ID: 465571  Cd Length: 113  Bit Score: 89.69  E-value: 4.43e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 980725790  110 DDLHGTLCRITDSYYRMFVDEPLMRDIWRATQADRALQALDEADGAFLAGLLTKRLREIAPDARDAQLSAFSELTMVLIA 189
Cdd:pfam17928   1 EGWWDALDRLIDRYAAMNRDEPVFRDLWFADQADPRLADIDADNNRALAARFARALAPLAPDGDGDELVRTAAVLMHLAD 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 980725790  190 AAVRYAIGLPPKAARQRLAMFKRTLPVDLA 219
Cdd:pfam17928  81 ALLRLAIALDPDEDDAIVDEAKRMLRRYLA 110
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
31-186 1.67e-10

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 57.60  E-value: 1.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 980725790  31 QQRSRERFERILACAAEVMVEKGCDAFRMSDIVERTGIAFGSLYQYFPDKTAVIGTLAERYnalgHECVRRDLSRMKRID 110
Cdd:COG1309    1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERL----LEELLAALEEALAAE 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 980725790 111 DLHGTLCRITDSYYRMFVDEPLMRDI--WRATQADRALQALDEADGAFLAGLLTKRLREIAPDARDAQLSAFSELTMV 186
Cdd:COG1309   77 DPRERLRALLRAYLEFLAENPALARLllAEAAELPELRAALRALLRRLRALLAELLRAGGLLADVDPDALARALLALL 154
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
41-84 5.62e-07

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 45.09  E-value: 5.62e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 980725790   41 ILACAAEVMVEKGCDAFRMSDIVERTGIAFGSLYQYFPDKTAVI 84
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELL 44
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
31-134 3.45e-04

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 40.27  E-value: 3.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 980725790  31 QQRSRERFERILACAAEVMVEKGCDAFRMSDIVERTGIAFGSLYQYFPDK----TAVIGTLAERYNALGHECVRRDLSRM 106
Cdd:NF041196   1 QERAIRTRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKealaRAVLEEQVARLREAVEPQRAGGGSKL 80

                         90       100
                 ....*....|....*....|....*...
gi 980725790 107 KriddlhgTLCRITDSYYRMFVDEPLMR 134
Cdd:NF041196  81 Q-------ELVDLTHVLARRLRTDPVVR 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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