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Conserved domains on  [gi|985376730|gb|KXA58310|]
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mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase [Streptococcus agalactiae]

Protein Classification

glycoside hydrolase family 73 protein( domain architecture ID 10004312)

glycoside hydrolase family 73 protein similar to Listeria monocytogenes virulence-associated peptidoglycan hydrolase Auto and Leuconostoc citreum atypical peptidoglycan hydrolase Mur

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FlgJ COG1705
Flagellum-specific peptidoglycan hydrolase FlgJ [Cell wall/membrane/envelope biogenesis, Cell ...
 43-188 1.07e-34

Flagellum-specific peptidoglycan hydrolase FlgJ [Cell wall/membrane/envelope biogenesis, Cell motility];


:

Pssm-ID: 441311 [Multi-domain]  Cd Length: 276  Bit Score: 123.54  E-value: 1.07e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376730  43 TKEEFIQKIVPDAQDLGKSYGIRPSFIIAQAALDSDFGEKIL-ANKYHNLFGLLAEPGT--PSITLNDSSTGK----KQE 115
Cdd:COG1705  128 SPEEFIAKIAPAAQKAAKKYGVPASVLIAQAALESGWGKSELdGSPSNNLFGIKAGGSWqgKSVEVTTTEYVNgkavKIK 207

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 985376730 116 KQFTHYKSWKYSMYDYLAHIKSgatgkKDSYTIMVSV-KNPKTLVQKLQDSGFDNDKKYAKKMTEIIDLYDLTR 188
Cdd:COG1705  208 ARFRAYDSYAESFRDYARLLKN-----NPRYAGALANaKDYEAFAKALQKAGYATDPKYADKLISIIESYNLTQ 276
 
Name Accession Description Interval E-value
FlgJ COG1705
Flagellum-specific peptidoglycan hydrolase FlgJ [Cell wall/membrane/envelope biogenesis, Cell ...
 43-188 1.07e-34

Flagellum-specific peptidoglycan hydrolase FlgJ [Cell wall/membrane/envelope biogenesis, Cell motility];


Pssm-ID: 441311 [Multi-domain]  Cd Length: 276  Bit Score: 123.54  E-value: 1.07e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376730  43 TKEEFIQKIVPDAQDLGKSYGIRPSFIIAQAALDSDFGEKIL-ANKYHNLFGLLAEPGT--PSITLNDSSTGK----KQE 115
Cdd:COG1705  128 SPEEFIAKIAPAAQKAAKKYGVPASVLIAQAALESGWGKSELdGSPSNNLFGIKAGGSWqgKSVEVTTTEYVNgkavKIK 207

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 985376730 116 KQFTHYKSWKYSMYDYLAHIKSgatgkKDSYTIMVSV-KNPKTLVQKLQDSGFDNDKKYAKKMTEIIDLYDLTR 188
Cdd:COG1705  208 ARFRAYDSYAESFRDYARLLKN-----NPRYAGALANaKDYEAFAKALQKAGYATDPKYADKLISIIESYNLTQ 276
LYZ2 smart00047
Lysozyme subfamily 2; Eubacterial enzymes distantly related to eukaryotic lysozymes.
 45-190 1.14e-21

Lysozyme subfamily 2; Eubacterial enzymes distantly related to eukaryotic lysozymes.


Pssm-ID: 214488 [Multi-domain]  Cd Length: 147  Bit Score: 85.95  E-value: 1.14e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376730    45 EEFIQKIVPDAQDLGKSYGIRPSFIIAQAALDSDFGEKILANKYHNLFGLLAEPGTPSITLNDSSTG----KKQEKQFTH 120
Cdd:smart00047   9 LEFVGKIFNEAQKAYQINGVYPSILIAQAALESGWGTSKLAKKYNNLFGIKGAYDGRPVRMGTLEYLnggwVTVKAAFRG 88

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 985376730   121 YKSWKYSMYDYLahiksgATGKKDSYTIMVSVKNPKTlvqklqdSGFDNDKKYAKKMTEIIDLYD--LTRYD 190
Cdd:smart00047  89 YFGEKFIDYAYV------LRGQNPLYKKRWGSNALQT-------AGYATDPDYAKKLIRIIALYDekLKGYD 147
PRK08581 PRK08581
amidase domain-containing protein;
45-191 1.89e-18

amidase domain-containing protein;


Pssm-ID: 236304 [Multi-domain]  Cd Length: 619  Bit Score: 82.14  E-value: 1.89e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376730  45 EEFIQKIVPDAQDLGKSYGIRPSFIIAQAALDSDFGEKILANK-YHNLFGLLAEPGTPSITLNDSSTGKKQ----EKQFT 119
Cdd:PRK08581 321 RQFIKSIAKDAHRIGQDNDIYASVMIAQAILESDSGQSALAKSpNHNLFGIKGAYEGNSVSFNTLEADGNQlysiNAGFR 400

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 985376730 120 HYKSWKYSMYDYLAHIKSGATGKKDSY--TIMVSVKNPKTLVQKLQDSgFDNDKKYAKKMTEIIDLYDLTRYDK 191
Cdd:PRK08581 401 KYPSTKESLEDYADLIKNGIDGNSTIYkpTWKSEAKSYKDATSHLSKT-YATDPNYAKKLNSIIKHYNLTQFDD 473
Glucosaminidase pfam01832
Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; This family includes ...
 52-131 1.46e-16

Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; This family includes Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase EC:3.2.1.96. As well as the flageller protein J that has been shown to hydrolyse peptidoglycan.


Pssm-ID: 460354 [Multi-domain]  Cd Length: 91  Bit Score: 71.06  E-value: 1.46e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376730   52 VPDAQDLGKSYGIRPSFIIAQAALDSDFGEKILANKYHNLFGLLAEPGTPSitlNDSSTGKKQEKQFTHYKSWKYSMYDY 131
Cdd:pfam01832   1 APAAIEAAKKYGIPASVLLAQAALESGWGTSRLAKESNNLFGIKASWKGKV---AYDTDEVTVAARFRKYDSVEESIRDY 77
sporang_Gsm NF038016
sporangiospore maturation cell wall hydrolase GsmA; The peptidoglycan-hydrolyzing enzyme GsmA ...
 43-190 7.94e-12

sporangiospore maturation cell wall hydrolase GsmA; The peptidoglycan-hydrolyzing enzyme GsmA occurs in some sporangia-forming members of the Actinobacteria, such as Actinoplanes missouriensis, and is required for proper separation of spores. GsmA proteins have one or two SH3 domains N-terminal to the hydrolase domain.


Pssm-ID: 411609 [Multi-domain]  Cd Length: 312  Bit Score: 62.45  E-value: 7.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376730  43 TKEEFIQKIVPDAQDLGKSYGIRPSFIIAQAALDSDFGEKILANKYHNLFGL--LAEPGTPSI------TLNDSSTGK-- 112
Cdd:NF038016 159 TPAQFIAAVAPPAQQSQRATGVPASVTIAQAILESGWGRSGLTREDHNYFGIkcFGSPGPIAVgcrsyaTFECSPTGGcf 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376730 113 KQEKQFTHYKSWKYSMYDY---LAHIKSGATGKKdsYTimvsvKNPKTLVQKLQDSGFDNDKKYAKKMTEIIDLYDLTRY 189
Cdd:NF038016 239 DTTATFRAYASAADSFRDHgrfLSVNSRYAPAFA--YT-----DDPDQFAREIHKAGYATDPTYADKLIGLMKQYNLYQY 311


                 .
gi 985376730 190 D 190
Cdd:NF038016 312 D 312
 
Name Accession Description Interval E-value
FlgJ COG1705
Flagellum-specific peptidoglycan hydrolase FlgJ [Cell wall/membrane/envelope biogenesis, Cell ...
 43-188 1.07e-34

Flagellum-specific peptidoglycan hydrolase FlgJ [Cell wall/membrane/envelope biogenesis, Cell motility];


Pssm-ID: 441311 [Multi-domain]  Cd Length: 276  Bit Score: 123.54  E-value: 1.07e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376730  43 TKEEFIQKIVPDAQDLGKSYGIRPSFIIAQAALDSDFGEKIL-ANKYHNLFGLLAEPGT--PSITLNDSSTGK----KQE 115
Cdd:COG1705  128 SPEEFIAKIAPAAQKAAKKYGVPASVLIAQAALESGWGKSELdGSPSNNLFGIKAGGSWqgKSVEVTTTEYVNgkavKIK 207

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 985376730 116 KQFTHYKSWKYSMYDYLAHIKSgatgkKDSYTIMVSV-KNPKTLVQKLQDSGFDNDKKYAKKMTEIIDLYDLTR 188
Cdd:COG1705  208 ARFRAYDSYAESFRDYARLLKN-----NPRYAGALANaKDYEAFAKALQKAGYATDPKYADKLISIIESYNLTQ 276
LYZ2 smart00047
Lysozyme subfamily 2; Eubacterial enzymes distantly related to eukaryotic lysozymes.
 45-190 1.14e-21

Lysozyme subfamily 2; Eubacterial enzymes distantly related to eukaryotic lysozymes.


Pssm-ID: 214488 [Multi-domain]  Cd Length: 147  Bit Score: 85.95  E-value: 1.14e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376730    45 EEFIQKIVPDAQDLGKSYGIRPSFIIAQAALDSDFGEKILANKYHNLFGLLAEPGTPSITLNDSSTG----KKQEKQFTH 120
Cdd:smart00047   9 LEFVGKIFNEAQKAYQINGVYPSILIAQAALESGWGTSKLAKKYNNLFGIKGAYDGRPVRMGTLEYLnggwVTVKAAFRG 88

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 985376730   121 YKSWKYSMYDYLahiksgATGKKDSYTIMVSVKNPKTlvqklqdSGFDNDKKYAKKMTEIIDLYD--LTRYD 190
Cdd:smart00047  89 YFGEKFIDYAYV------LRGQNPLYKKRWGSNALQT-------AGYATDPDYAKKLIRIIALYDekLKGYD 147
PRK08581 PRK08581
amidase domain-containing protein;
45-191 1.89e-18

amidase domain-containing protein;


Pssm-ID: 236304 [Multi-domain]  Cd Length: 619  Bit Score: 82.14  E-value: 1.89e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376730  45 EEFIQKIVPDAQDLGKSYGIRPSFIIAQAALDSDFGEKILANK-YHNLFGLLAEPGTPSITLNDSSTGKKQ----EKQFT 119
Cdd:PRK08581 321 RQFIKSIAKDAHRIGQDNDIYASVMIAQAILESDSGQSALAKSpNHNLFGIKGAYEGNSVSFNTLEADGNQlysiNAGFR 400

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 985376730 120 HYKSWKYSMYDYLAHIKSGATGKKDSY--TIMVSVKNPKTLVQKLQDSgFDNDKKYAKKMTEIIDLYDLTRYDK 191
Cdd:PRK08581 401 KYPSTKESLEDYADLIKNGIDGNSTIYkpTWKSEAKSYKDATSHLSKT-YATDPNYAKKLNSIIKHYNLTQFDD 473
Glucosaminidase pfam01832
Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; This family includes ...
 52-131 1.46e-16

Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; This family includes Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase EC:3.2.1.96. As well as the flageller protein J that has been shown to hydrolyse peptidoglycan.


Pssm-ID: 460354 [Multi-domain]  Cd Length: 91  Bit Score: 71.06  E-value: 1.46e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376730   52 VPDAQDLGKSYGIRPSFIIAQAALDSDFGEKILANKYHNLFGLLAEPGTPSitlNDSSTGKKQEKQFTHYKSWKYSMYDY 131
Cdd:pfam01832   1 APAAIEAAKKYGIPASVLLAQAALESGWGTSRLAKESNNLFGIKASWKGKV---AYDTDEVTVAARFRKYDSVEESIRDY 77
flgJ PRK05684
flagellar assembly peptidoglycan hydrolase FlgJ;
45-181 2.77e-13

flagellar assembly peptidoglycan hydrolase FlgJ;


Pssm-ID: 235559 [Multi-domain]  Cd Length: 312  Bit Score: 66.44  E-value: 2.77e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376730  45 EEFIQKIVPDAQDLGKSYGIRPSFIIAQAALDSDFGEKILANK----YHNLFGLLAE-----PGTPSITLN-DSSTGKKQ 114
Cdd:PRK05684 153 DDFVARLSPPAQKAAQQSGVPHHLLLAQAALESGWGQREIRTAdgspSHNLFGIKADgswkgPVTEITTTEyENGVAVKV 232

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 985376730 115 EKQFTHYKSWKYSMYDYLAHIKSGatgkkDSYTIMVSVKNPKTLVQKLQDSGFDNDKKYAKKMTEII 181
Cdd:PRK05684 233 KAAFRVYDSYLESFNDYVSLLTNN-----PRYAAVTQAASPEQFARALQDAGYATDPNYARKLVSVI 294
sporang_Gsm NF038016
sporangiospore maturation cell wall hydrolase GsmA; The peptidoglycan-hydrolyzing enzyme GsmA ...
 43-190 7.94e-12

sporangiospore maturation cell wall hydrolase GsmA; The peptidoglycan-hydrolyzing enzyme GsmA occurs in some sporangia-forming members of the Actinobacteria, such as Actinoplanes missouriensis, and is required for proper separation of spores. GsmA proteins have one or two SH3 domains N-terminal to the hydrolase domain.


Pssm-ID: 411609 [Multi-domain]  Cd Length: 312  Bit Score: 62.45  E-value: 7.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376730  43 TKEEFIQKIVPDAQDLGKSYGIRPSFIIAQAALDSDFGEKILANKYHNLFGL--LAEPGTPSI------TLNDSSTGK-- 112
Cdd:NF038016 159 TPAQFIAAVAPPAQQSQRATGVPASVTIAQAILESGWGRSGLTREDHNYFGIkcFGSPGPIAVgcrsyaTFECSPTGGcf 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376730 113 KQEKQFTHYKSWKYSMYDY---LAHIKSGATGKKdsYTimvsvKNPKTLVQKLQDSGFDNDKKYAKKMTEIIDLYDLTRY 189
Cdd:NF038016 239 DTTATFRAYASAADSFRDHgrfLSVNSRYAPAFA--YT-----DDPDQFAREIHKAGYATDPTYADKLIGLMKQYNLYQY 311


                 .
gi 985376730 190 D 190
Cdd:NF038016 312 D 312
flgJ PRK12709
flagellar rod assembly protein/muramidase FlgJ; Provisional
 45-181 5.14e-11

flagellar rod assembly protein/muramidase FlgJ; Provisional


Pssm-ID: 237179 [Multi-domain]  Cd Length: 320  Bit Score: 60.32  E-value: 5.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376730  45 EEFIQKIVPDAQDLGKSYGIRPSFIIAQAALDSDFGEKIL----ANKYHNLFGLLAEPGTPSITLNDSST----GKKQE- 115
Cdd:PRK12709 174 DAFVDKLAAPAQAASAATGIPARFIVGQAALESGWGKREIrgadGSTSYNVFGIKATKGWTGRTVSAVTTeyvnGKPRRv 253

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 985376730 116 -KQFTHYKSWKYSMYDYLAHIKSGAtgkkdSYT-IMVSVKNPKTLVQKLQDSGFDNDKKYAKKMTEII 181
Cdd:PRK12709 254 vAKFRAYDSYEHAMTDYANLLKNNP-----RYAgVLNASRSVEGFAHGMQKAGYATDPHYAKKLISIM 316
PRK06347 PRK06347
1,4-beta-N-acetylmuramoylhydrolase;
43-190 2.02e-08

1,4-beta-N-acetylmuramoylhydrolase;


Pssm-ID: 180536 [Multi-domain]  Cd Length: 592  Bit Score: 53.16  E-value: 2.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376730  43 TKEEFIQKIVPDAQDLGKSYGIRPSFIIAQAALDSDFGEKILANK-YHNLFGLLAEPGTPSIT---LNDSSTGKKQE--K 116
Cdd:PRK06347 149 TVQSFIQTIQASSSQIAAENDLYASVMIAQAILESAYGTSELGSApNYNLFGIKGAYNGQSYTkqtLEDDGKGNYYTitA 228

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 985376730 117 QFTHYKSWKYSMYDYLAHIKSGATGKKDSYTIM--VSVKNPKTLVQKLQDSgFDNDKKYAKKMTEIIDLYDLTRYD 190
Cdd:PRK06347 229 KFRKYPSYHQSLEDYAQVIRKGPSWNPNYYSKVwkSNTTSYKDATKALTGT-YATDTAYATKLNDLISRYNLTQYD 303
flgJ PRK12710
flagellar rod assembly protein/muramidase FlgJ; Provisional
 35-180 1.14e-07

flagellar rod assembly protein/muramidase FlgJ; Provisional


Pssm-ID: 139170 [Multi-domain]  Cd Length: 291  Bit Score: 50.56  E-value: 1.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376730  35 NSRQSVTYTkEEFIQKIVPDAQDLGKSYGIRPSFIIAQAALDSDFGEKIL----ANKYHNLFGLL--AEPGTPSITLNDS 108
Cdd:PRK12710 122 NSEESLSVV-DDFVKSVWPTAKQAASLIGLDPKLLVAQAALETGWGKFVTrdadGSSSNNLFNIKtgSHSEVESIQVKTT 200

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 985376730 109 S----TGKKQEKQFTHYKSWKYSMYDYLAHIKsgatGKKDSYTIMVSVKNPKTLVQKLQDSGFDNDKKYAKKMTEI 180
Cdd:PRK12710 201 EyiadTPIKINASFRKYPSIEHSFHDYVSLIK----GSERYQMALANAENPEIYVSELNKAGYATDPNYSNKILSI 272
flgJ PRK12711
flagellar assembly peptidoglycan hydrolase FlgJ;
43-180 2.35e-07

flagellar assembly peptidoglycan hydrolase FlgJ;


Pssm-ID: 237180 [Multi-domain]  Cd Length: 392  Bit Score: 49.58  E-value: 2.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376730  43 TKEEFIQKIVPDAQDLGKSYGIRPSFIIAQAALDSDFGEKILAN--KYHNLFGLLAE--PGTPSIT-LNDSSTGKKQEK- 116
Cdd:PRK12711 214 TPEGFVAKIWTHAQKAARELGVDPRALVAQAALETGWGRRGIGNggDSNNLFGIKATgwNGDKVTTgTHEYVNGVKTTEt 293

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 985376730 117 -QFTHYKSWKYSMYDYLAHIKSGATGKkdsyTIMVSVKNPKTLVQKLQDSGFDNDKKYAKKMTEI 180
Cdd:PRK12711 294 aDFRAYGSAEESFADYVRLLKNNSRYQ----QALQAGTDIKGFARGLQQAGYATDPGYAAKIAAI 354
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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