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Conserved domains on  [gi|985376732|gb|KXA58312|]
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co-chaperone GrpE [Streptococcus agalactiae]

Protein Classification

nucleotide exchange factor GrpE( domain architecture ID 10793988)

nucleotide exchange factor GrpE functions as a nucleotide exchange factor for DnaK and participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may also function as a thermosensor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK14156 PRK14156
heat shock protein GrpE; Provisional
 14-190 9.45e-92

heat shock protein GrpE; Provisional


:

Pssm-ID: 237628 [Multi-domain]  Cd Length: 177  Bit Score: 265.54  E-value: 9.45e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  14 VSEEIKKDDLQEEVEATETEETVEEVIEEIPEKSELELANERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLA 93
Cdd:PRK14156   1 MSEEIKNEEVEEEVEATETEETVEEVVEETPEKSELELANERADEFENKYLRAHAEMQNIQRRANEERQQLQRYRSQDLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  94 KAILPSLDNLERALAVEGLTDDVKKGLEMTRDSLIQALKEEGVEEVEVDSFDHNFHMAVQTLPADDEHPADSIAEVFQKG 173
Cdd:PRK14156  81 KAILPSLDNLERALAVEGLTDDVKKGLEMVQESLIQALKEEGVEEVAVDSFDHNLHMAVQTLPADDEHPADSIAQVFQKG 160

                        170
                 ....*....|....*..
gi 985376732 174 YKLHERLLRPAMVVVYN 190
Cdd:PRK14156 161 YKLHERLLRPAMVVVYN 177
 
Name Accession Description Interval E-value
PRK14156 PRK14156
heat shock protein GrpE; Provisional
 14-190 9.45e-92

heat shock protein GrpE; Provisional


Pssm-ID: 237628 [Multi-domain]  Cd Length: 177  Bit Score: 265.54  E-value: 9.45e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  14 VSEEIKKDDLQEEVEATETEETVEEVIEEIPEKSELELANERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLA 93
Cdd:PRK14156   1 MSEEIKNEEVEEEVEATETEETVEEVVEETPEKSELELANERADEFENKYLRAHAEMQNIQRRANEERQQLQRYRSQDLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  94 KAILPSLDNLERALAVEGLTDDVKKGLEMTRDSLIQALKEEGVEEVEVDSFDHNFHMAVQTLPADDEHPADSIAEVFQKG 173
Cdd:PRK14156  81 KAILPSLDNLERALAVEGLTDDVKKGLEMVQESLIQALKEEGVEEVAVDSFDHNLHMAVQTLPADDEHPADSIAQVFQKG 160

                        170
                 ....*....|....*..
gi 985376732 174 YKLHERLLRPAMVVVYN 190
Cdd:PRK14156 161 YKLHERLLRPAMVVVYN 177
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 50-190 4.75e-44

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 143.37  E-value: 4.75e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  50 ELANERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVK---KGLEMTRDS 126
Cdd:COG0576    2 EELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAEEDEDVKsllEGVEMTLKQ 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 985376732 127 LIQALKEE--GVEEVEVDSFDHNFHMAVQTLPaDDEHPADSIAEVFQKGYKLHERLLRPAMVVVYN 190
Cdd:COG0576   82 LLDVLEKHgvEEIEPVGEPFDPNLHEAVSQVP-SPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAK 146
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 57-188 1.14e-43

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 141.87  E-value: 1.14e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  57 DEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVK---KGLEMTRDSLIQALKE 133
Cdd:cd00446    1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKEEELKnllEGVEMTLKQLLKVLEK 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 985376732 134 E--GVEEVEVDSFDHNFHMAVQTLPaDDEHPADSIAEVFQKGYKLHERLLRPAMVVV 188
Cdd:cd00446   81 HgvEEIEPEGEKFDPNLHEAVMQVE-SPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
GrpE pfam01025
GrpE;
46-188 7.75e-40

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 133.12  E-value: 7.75e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732   46 KSELELANERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVK---KGLEM 122
Cdd:pfam01025  17 EEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSAPENEDVKsllEGVEM 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 985376732  123 TRDSLIQALKEE--GVEEVEVDSFDHNFHMAVQTLPaDDEHPADSIAEVFQKGYKLHERLLRPAMVVV 188
Cdd:pfam01025  97 TLKQLLKILEKHgvEKIEPEGEPFDPNLHEAVSQVP-SPEKPEGTVVEVLQKGYKLHDRVLRPAMVVV 163
 
Name Accession Description Interval E-value
PRK14156 PRK14156
heat shock protein GrpE; Provisional
 14-190 9.45e-92

heat shock protein GrpE; Provisional


Pssm-ID: 237628 [Multi-domain]  Cd Length: 177  Bit Score: 265.54  E-value: 9.45e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  14 VSEEIKKDDLQEEVEATETEETVEEVIEEIPEKSELELANERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLA 93
Cdd:PRK14156   1 MSEEIKNEEVEEEVEATETEETVEEVVEETPEKSELELANERADEFENKYLRAHAEMQNIQRRANEERQQLQRYRSQDLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  94 KAILPSLDNLERALAVEGLTDDVKKGLEMTRDSLIQALKEEGVEEVEVDSFDHNFHMAVQTLPADDEHPADSIAEVFQKG 173
Cdd:PRK14156  81 KAILPSLDNLERALAVEGLTDDVKKGLEMVQESLIQALKEEGVEEVAVDSFDHNLHMAVQTLPADDEHPADSIAQVFQKG 160

                        170
                 ....*....|....*..
gi 985376732 174 YKLHERLLRPAMVVVYN 190
Cdd:PRK14156 161 YKLHERLLRPAMVVVYN 177
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 50-190 4.75e-44

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 143.37  E-value: 4.75e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  50 ELANERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVK---KGLEMTRDS 126
Cdd:COG0576    2 EELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAEEDEDVKsllEGVEMTLKQ 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 985376732 127 LIQALKEE--GVEEVEVDSFDHNFHMAVQTLPaDDEHPADSIAEVFQKGYKLHERLLRPAMVVVYN 190
Cdd:COG0576   82 LLDVLEKHgvEEIEPVGEPFDPNLHEAVSQVP-SPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAK 146
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 57-188 1.14e-43

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 141.87  E-value: 1.14e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  57 DEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVK---KGLEMTRDSLIQALKE 133
Cdd:cd00446    1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKEEELKnllEGVEMTLKQLLKVLEK 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 985376732 134 E--GVEEVEVDSFDHNFHMAVQTLPaDDEHPADSIAEVFQKGYKLHERLLRPAMVVV 188
Cdd:cd00446   81 HgvEEIEPEGEKFDPNLHEAVMQVE-SPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
PRK14162 PRK14162
heat shock protein GrpE; Provisional
 46-188 2.10e-42

heat shock protein GrpE; Provisional


Pssm-ID: 237631 [Multi-domain]  Cd Length: 194  Bit Score: 140.74  E-value: 2.10e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  46 KSELELANERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEGlTDDV----KKGLE 121
Cdd:PRK14162  45 EKEIADLKAKNKDLEDKYLRSQAEIQNMQNRYAKERAQLIKYESQSLAKDVLPAMDNLERALAVKA-DDEAakqlKKGVQ 123

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 985376732 122 MTRDSLIQALKEEGVEEVEVD--SFDHNFHMAVQTLPADDEHPADSIAEVFQKGYKLHERLLRPAMVVV 188
Cdd:PRK14162 124 MTLDHLVKALKDHGVTEIKADgeKFDPTLHQAVQTVAAENDDQKDHVVQVLQKGYQYKDRTLRPAMVVV 192
GrpE pfam01025
GrpE;
46-188 7.75e-40

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 133.12  E-value: 7.75e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732   46 KSELELANERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVK---KGLEM 122
Cdd:pfam01025  17 EEEIEELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSAPENEDVKsllEGVEM 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 985376732  123 TRDSLIQALKEE--GVEEVEVDSFDHNFHMAVQTLPaDDEHPADSIAEVFQKGYKLHERLLRPAMVVV 188
Cdd:pfam01025  97 TLKQLLKILEKHgvEKIEPEGEPFDPNLHEAVSQVP-SPEKPEGTVVEVLQKGYKLHDRVLRPAMVVV 163
PRK14140 PRK14140
heat shock protein GrpE; Provisional
 48-188 2.76e-35

heat shock protein GrpE; Provisional


Pssm-ID: 237622 [Multi-domain]  Cd Length: 191  Bit Score: 122.42  E-value: 2.76e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  48 ELElanERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVK---KGLEMTR 124
Cdd:PRK14140  48 ELE---AKLDELEERYLRLQADFENYKRRIQKENEAAEKYRAQSLASDLLPALDNFERALQIEADDEQTKsllKGVEMVH 124

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 985376732 125 DSLIQALKEE--GVEEVEVDSFDHNFHMAVQTLPaDDEHPADSIAEVFQKGYKLHERLLRPAMVVV 188
Cdd:PRK14140 125 RQLLEALKKEgvEVIEAVGEQFDPNLHQAVMQDE-DEDFESNEVVEELQKGYKLKDRVIRPSMVKV 189
PRK14160 PRK14160
heat shock protein GrpE; Provisional
 16-190 5.08e-25

heat shock protein GrpE; Provisional


Pssm-ID: 237629 [Multi-domain]  Cd Length: 211  Bit Score: 96.36  E-value: 5.08e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  16 EEIKKDDLQEEVEATETEETVEEVIEEIPEKSELELANERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKA 95
Cdd:PRK14160  37 EEIEKEEIIEDSEESNEVKIEELKDENNKLKEENKKLENELEALKDRLLRTVAEYDNYRKRTAKEKEGIYSDACEDVLKE 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  96 ILPSLDNLERALAVEGLTDDVKKGLEMTRDSLIQAL-KEEGVEEVEVDSFDHNFHMAVQTLpADDEHPADSIAEVFQKGY 174
Cdd:PRK14160 117 LLPVLDNLERAAAVEGSVEDLKKGIEMTVKQFKTSLeKLGVEEISTEGEFDPNLHNAVMHV-EDENYGENEIVEVFQKGY 195

                        170
                 ....*....|....*.
gi 985376732 175 KLHERLLRPAMVVVYN 190
Cdd:PRK14160 196 KRGDKVIRYSMVKVAN 211
PRK14139 PRK14139
heat shock protein GrpE; Provisional
 48-188 2.91e-24

heat shock protein GrpE; Provisional


Pssm-ID: 237621 [Multi-domain]  Cd Length: 185  Bit Score: 93.89  E-value: 2.91e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  48 ELELANERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEGLT-DDVKKGLEMTRDS 126
Cdd:PRK14139  40 ELAEAEAKAAELQDSFLRAKAETENVRRRAQEDVAKAHKFAIESFAESLLPVKDSLEAALADESGDlEKLREGVELTLKQ 119

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 985376732 127 LIQALKEEGVEEV--EVDSFDHNFHMAVQTLPADDEhpADSIAEVFQKGYKLHERLLRPAMVVV 188
Cdd:PRK14139 120 LTSAFEKGRVVEInpVGEKFDPHQHQAISMVPAEQE--PNTVVAVLQKGYTIADRVLRPALVTV 181
PRK14158 PRK14158
heat shock protein GrpE; Provisional
 48-188 5.54e-23

heat shock protein GrpE; Provisional


Pssm-ID: 172646 [Multi-domain]  Cd Length: 194  Bit Score: 90.76  E-value: 5.54e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  48 ELELANERADEFEN--KYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERAL--AVEGLTDDVKKGLEMT 123
Cdd:PRK14158  46 EEALAAKEAEAAANwdKYLRERADLENYRKRVQKEKEELLKYGNESLILEILPAVDNMERALdhADEESMSAIIEGIRMT 125

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 985376732 124 RDSLIQALKE---EGVEEVEVDSFDHNFHMAVQTLPADdEHPADSIAEVFQKGYKLHERLLRPAMVVV 188
Cdd:PRK14158 126 LSMLLSTLKKfgvTPVEAEKGTPFDPAYHQAMCQVESA-EQEPNTVVAVFQKGYLLNERLLRPAMVSV 192
PRK14150 PRK14150
heat shock protein GrpE; Provisional
 47-188 1.63e-22

heat shock protein GrpE; Provisional


Pssm-ID: 184539 [Multi-domain]  Cd Length: 193  Bit Score: 89.21  E-value: 1.63e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  47 SELELANERADEFE-----------NKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEGLTDD 115
Cdd:PRK14150  34 DELDEADARIAELEaqlaeaqaeerDSVLRARAEVENIRRRAEQDVEKAHKFALEKFANELLPVIDNLERALQAADKENE 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 985376732 116 VKK----GLEMTRDSLIQALKE--EGVEEVEVDSFDHNFHMAVQTLPADDeHPADSIAEVFQKGYKLHERLLRPAMVVV 188
Cdd:PRK14150 114 ALKalieGVELTLKSLLDTVAKfgVEVVGPVGEPFNPEVHQAISMQESED-HEPNTVMMVMQKGYTLNGRLLRPAMVMV 191
PRK14144 PRK14144
heat shock protein GrpE; Provisional
 6-188 1.48e-21

heat shock protein GrpE; Provisional


Pssm-ID: 184535 [Multi-domain]  Cd Length: 199  Bit Score: 87.09  E-value: 1.48e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732   6 KLFKRRHSVSEEIKKDDLQEEVEATETEETVEEVIEEIPEKSE-LELANERADEFENKYLRAHAEMQNIQRRSSEERQQL 84
Cdd:PRK14144  10 KKFKDEHKEEHKVENEILEEETDEESQHQEPALGHPSYTALEEqLTLAEQKAHENWEKSVRALAELENVRRRMEREVANA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  85 QRYRSQDLAKAILPSLDNLERALAVEGLTDD--VKKGLEMTRDSLIQALKEEGVEEVEV--DSFDHNFHMAVQTLPADDE 160
Cdd:PRK14144  90 HKYGVEKLISALLPVVDSLEQALQLADKNSDpsMHEGLELTMKLFLDALQKFDVEQIDPlgQTFDPQQHEAMSMQPAPGA 169

                        170       180
                 ....*....|....*....|....*...
gi 985376732 161 HPaDSIAEVFQKGYKLHERLLRPAMVVV 188
Cdd:PRK14144 170 PP-NSVITVFQKGYKLSDRVIRPARVIV 196
PRK14151 PRK14151
heat shock protein GrpE; Provisional
 64-188 1.85e-19

heat shock protein GrpE; Provisional


Pssm-ID: 172640 [Multi-domain]  Cd Length: 176  Bit Score: 80.98  E-value: 1.85e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  64 LRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEGLTDD----VKKGLEMTRDSLIQALKEEGVEEV 139
Cdd:PRK14151  44 LRAAADLQNVRRRAEQDVEKAHKFALEKFAGDLLPVVDSLERGLELSSADDEaikpMREGVELTLKMFQDTLKRYQLEAV 123

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 985376732 140 --EVDSFDHNFHMAVQTLPADDEHPaDSIAEVFQKGYKLHERLLRPAMVVV 188
Cdd:PRK14151 124 dpHGEPFNPEHHQAMAMQESADVEP-NSVLKVFQKGYLLNGRLLRPAMVVV 173
PRK14155 PRK14155
heat shock protein GrpE; Provisional
 48-188 2.22e-19

heat shock protein GrpE; Provisional


Pssm-ID: 237627 [Multi-domain]  Cd Length: 208  Bit Score: 81.55  E-value: 2.22e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  48 ELELANERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAV--EGLTDDVKK----GLE 121
Cdd:PRK14155  21 EIEALKAEVAALKDQALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLGRATAAspKDSADPAVKnfiiGVE 100

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732 122 MTRDSLIQALKE---EGVEEVEVDSFDHNFHMAVQTLPAdDEHPADSIAEVFQKGYKLHERLLRPAMVVV 188
Cdd:PRK14155 101 MTEKELLGAFERnglKKIDPAKGDKFDPHLHQAMMEQPS-TEVAAGGVLQVMQAGYELMGRLVRPAMVAV 169
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 49-188 4.31e-19

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 80.87  E-value: 4.31e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  49 LELANERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERAL----------AVEGLTDDVkK 118
Cdd:PRK14141  40 LEALKAENAELKDRMLRLAAEMENLRKRTQRDVADARAYGIAGFARDMLSVSDNLRRALdaipaearaaADAGLKALI-E 118

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 985376732 119 GLEMTRDSLIQALKEE--GVEEVEVDSFDHNFHMAVQTLPaDDEHPADSIAEVFQKGYKLHERLLRPAMVVV 188
Cdd:PRK14141 119 GVEMTERAMLNALERHgvKKLDPEGQKFDPNFHQAMFEVP-NPDVPNNTVVQVVQAGYTIGERVLRPAMVGV 189
PRK14149 PRK14149
heat shock protein GrpE; Provisional
 58-188 1.16e-18

heat shock protein GrpE; Provisional


Pssm-ID: 184538 [Multi-domain]  Cd Length: 191  Bit Score: 79.15  E-value: 1.16e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  58 EFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEGLTDD---VKKGLEMTRDSLIQAL-KE 133
Cdd:PRK14149  54 EMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGALKSAAEVDKesaLTKGLELTMEKLHEVLaRH 133

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 985376732 134 EGVEEVEVDSFDHNFHMAVQTLPaDDEHPADSIAEVFQKGYKLHERLLRPAMVVV 188
Cdd:PRK14149 134 GIEGIECLEEFDPNFHNAIMQVK-SEEKENGKIVQVLQQGYKYKGRVLRPAMVSI 187
PRK14159 PRK14159
heat shock protein GrpE; Provisional
 46-188 4.12e-17

heat shock protein GrpE; Provisional


Pssm-ID: 172647 [Multi-domain]  Cd Length: 176  Bit Score: 75.11  E-value: 4.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  46 KSELELANERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEG---LTDDVKKGLEM 122
Cdd:PRK14159  29 DVEQNKLQKDYDELKDKYMRANAEFENIKKRMEKEKLSAMAYANESFAKDLLDVLDALEAAVNVEChdeISLKIKEGVQN 108

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 985376732 123 TRDSLIQAL-KEEGVEEVEVDSFDHNFHMAVQTLPADDeHPADSIAEVFQKGYKLHERLLRPAMVVV 188
Cdd:PRK14159 109 TLDLFLKKLeKHGVALIKEEKEFDPNLHEAMFHVDSEN-HQSGEVVQVLQKGYKIADRVIRPTKVSV 174
PRK14148 PRK14148
heat shock protein GrpE; Provisional
 54-188 2.96e-16

heat shock protein GrpE; Provisional


Pssm-ID: 172637 [Multi-domain]  Cd Length: 195  Bit Score: 73.25  E-value: 2.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  54 ERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEGLTDD---VKKGLEMTRDSLIQA 130
Cdd:PRK14148  54 DSCDQFKDEALRAKAEMENIRKRAERDVSNARKFGIEKFAKELLPVIDSIEQALKHEVKLEEaiaMKEGIELTAKMLVDI 133

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732 131 LKEE--GVEEVEVDSFDHNFHMAVQTLPaDDEHPADSIAEVFQKGYKLHERLLRPAMVVV 188
Cdd:PRK14148 134 LKKNgvEELDPKGEKFDPNLHEAMAMIP-NPEFEDNTIFDVFQKGYMLNGRIVRAAKVVI 192
PRK14154 PRK14154
heat shock protein GrpE; Provisional
 46-188 2.89e-15

heat shock protein GrpE; Provisional


Pssm-ID: 237626 [Multi-domain]  Cd Length: 208  Bit Score: 70.61  E-value: 2.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  46 KSELELANERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEGLTD----DVKKGLE 121
Cdd:PRK14154  58 EGQLTRMERKVDEYKTQYLRAQAEMDNLRKRIEREKADIIKFGSKQLITDLLPVADSLIHGLESPASEDpqvkSMRDGMS 137

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 985376732 122 MTRDSLIQALKEEGVEEVEV---DSFDHNFH--MAVQTLPadDEHPaDSIAEVFQKGYKLHERLLRPAMVVV 188
Cdd:PRK14154 138 LTLDLLHNTLAKHGVQVINPnpgDPFDPALHeaMSVQAVP--DAKP-DTIIQVLQKGYQLNGRVLRAARVIV 206
PRK14161 PRK14161
heat shock protein GrpE; Provisional
 48-188 9.34e-15

heat shock protein GrpE; Provisional


Pssm-ID: 237630 [Multi-domain]  Cd Length: 178  Bit Score: 68.85  E-value: 9.34e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  48 ELELANERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVK-----KGLEM 122
Cdd:PRK14161  27 EITALKAEIEELKDKLIRTTAEIDNTRKRLEKARDEAKDYAIATFAKELLNVSDNLSRALAHKPANSDVEvtniiAGVQM 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 985376732 123 TRDSLIQALKEEGVEEVEVD---SFDHNFHMAVQTLPADDEHPaDSIAEVFQKGYKLHERLLRPAMVVV 188
Cdd:PRK14161 107 TKDELDKVFHKHHIEEIKPEigsMFDYNLHNAISQIEHPDHAP-NSIITLMQSGYKIRDRLLRPATVQV 174
PRK14147 PRK14147
heat shock protein GrpE; Provisional
 50-188 1.09e-14

heat shock protein GrpE; Provisional


Pssm-ID: 237625 [Multi-domain]  Cd Length: 172  Bit Score: 68.44  E-value: 1.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  50 ELANERADEfenkyLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEGLTDD-VKKGLEMTRDSLI 128
Cdd:PRK14147  33 EIALVKADA-----LRERADLENQRKRIARDVEQARKFANEKLLGELLPVFDSLDAGLTAAGTEPSpLRDGLELTYKQLL 107

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 985376732 129 Q--ALKEEGVEEVEVDSFDHNFHMAVQTLPADDEHPAdSIAEVFQKGYKLHERLLRPAMVVV 188
Cdd:PRK14147 108 KvaADNGLTLLDPVGQPFNPEHHQAISQGEAEGVAPG-HVVQVFQKGYLLNERLLRPALVVV 168
PRK14153 PRK14153
heat shock protein GrpE; Provisional
 47-188 4.95e-14

heat shock protein GrpE; Provisional


Pssm-ID: 184540 [Multi-domain]  Cd Length: 194  Bit Score: 67.17  E-value: 4.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  47 SELELANERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVK---KGLEMT 123
Cdd:PRK14153  40 SETEKCREEIESLKEQLFRLAAEFDNFRKRTAREMEENRKFVLEQVLLDLLEVTDNFERALESARTAEDMNsivEGIEMV 119

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 985376732 124 RDSLIQALKEE--GVEEVEVDSFDHNFHMAVQTLPAdDEHPADSIAEVFQKGYKLHERLLRPAMVVV 188
Cdd:PRK14153 120 SKQFFSILEKYglERIECEGEEFDPHRHEAMMHVET-SEVPDNTIVDVCKPGYALNSKVIRPAMVSV 185
PRK14145 PRK14145
heat shock protein GrpE; Provisional
 46-188 3.13e-13

heat shock protein GrpE; Provisional


Pssm-ID: 184536 [Multi-domain]  Cd Length: 196  Bit Score: 64.94  E-value: 3.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  46 KSELELANERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVKKGLEMTRD 125
Cdd:PRK14145  51 KQKLQQKEVEAQEYLDIAQRLKAEFENYRKRTEKEKSEMVEYGKEQVILELLPVMDNFERALASSGDYNSLKEGIELIYR 130

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 985376732 126 SLIQALKEEGVEEVEVDS--FDHNFHMAVQTLPADDEHPaDSIAEVFQKGYKLHERLLRPAMVVV 188
Cdd:PRK14145 131 QFKKILDKFGVKEIEAEGqiFDPYKHHAVMQEEVEGKQP-NEIIEVFQKGYYLKDKVIRPSLVKV 194
PRK10325 PRK10325
heat shock protein GrpE; Provisional
 48-188 2.34e-12

heat shock protein GrpE; Provisional


Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 62.77  E-value: 2.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  48 ELELANERADEFENkYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEGLTDD----VKKGLEMT 123
Cdd:PRK10325  48 EAQLAEAQTRERDG-ILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKANPdmsaMVEGIELT 126

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 985376732 124 RDSLIQALKEEGVEEVEVDS--FDHNFHMAVQTLPADDEHPADSIAeVFQKGYKLHERLLRPAMVVV 188
Cdd:PRK10325 127 LKSMLDVVRKFGVEVIAETNvpLDPNVHQAIAMVESDDVAPGNVLG-IMQKGYTLNGRTIRAAMVTV 192
PRK14143 PRK14143
heat shock protein GrpE; Provisional
 48-188 1.35e-11

heat shock protein GrpE; Provisional


Pssm-ID: 237624 [Multi-domain]  Cd Length: 238  Bit Score: 61.28  E-value: 1.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  48 ELELANERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVKKGLEMTRDS- 126
Cdd:PRK14143  75 ELESLKQELEELNSQYMRIAADFDNFRKRTSREQEDLRLQLKCNTLSEILPVVDNFERARQQLKPEGEEAQALHRSYQGl 154

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 985376732 127 ---LIQALKEE--GVEEVEVDSFDHNFHMAVQTLPADdEHPADSIAEVFQKGYKLHERLLRPAMVVV 188
Cdd:PRK14143 155 ykqLVDVLKRLgvSPMRVVGQEFDPNLHEAVLREPSD-EHPEDVVLEELQRGYHLGGRVLRHAMVKV 220
PRK14164 PRK14164
heat shock protein GrpE; Provisional
 48-188 2.77e-11

heat shock protein GrpE; Provisional


Pssm-ID: 237632 [Multi-domain]  Cd Length: 218  Bit Score: 60.20  E-value: 2.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  48 ELELAnERADEFEnkylRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERAlAVEGltdDVKKG-LEMTRDS 126
Cdd:PRK14164  83 EAQLA-ERTEDLQ----RVTAEYANYRRRTERERQAIIETAKAGVATDLLPILDDLDLA-EQHG---DLNEGpLKAFSDK 153

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 985376732 127 LIQALKEEGVEE--VEVDSFDHNFHMAVQTLPADDEHpadSIAEVFQKGYKLHERLLRPAMVVV 188
Cdd:PRK14164 154 LTNVLAGLKVEKfgEEGDAFDPEIHEAVQDLSSGDEK---VLGTVLRKGYRMGDRVLRTAMVII 214
PRK14146 PRK14146
heat shock protein GrpE; Provisional
 46-188 5.87e-11

heat shock protein GrpE; Provisional


Pssm-ID: 172635 [Multi-domain]  Cd Length: 215  Bit Score: 58.98  E-value: 5.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  46 KSELELANERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVK---KGLEM 122
Cdd:PRK14146  60 QKELDNAKKEIESLKDSWARERAEFQNFKRRSAQEFVSIRKEAVKSLVSGFLNPIDNLERVGATQNQSEELKpfvEGVKM 139

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 985376732 123 TRDSLIQALKEEGVEEV--EVDSFDhnfHMAVQTLPAD--DEHPADSIAEVFQKGYKLHE----RLLRPAMVVV 188
Cdd:PRK14146 140 ILKEFYSVLEKSNVIRFdpKGEPFD---PMSMEALSSEegDQYSEETVIDVYQAGYYYKEnedkFTLRPARVRI 210
PRK14163 PRK14163
heat shock protein GrpE; Provisional
 53-188 3.71e-08

heat shock protein GrpE; Provisional


Pssm-ID: 184546 [Multi-domain]  Cd Length: 214  Bit Score: 51.28  E-value: 3.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  53 NERADEFEnkylRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERAL---AVEGLTDDVKKGLEMTRDSL-I 128
Cdd:PRK14163  57 GERTADLQ----RLQAEYQNYRRRVERDRVTVKEIAVANLLSELLPVLDDVGRARehgELVGGFKSVAESLETTVAKLgL 132

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732 129 QALKeegveeVEVDSFDHNFHMAVQTLPADDEHPADSIAeVFQKGYKLHERLLRPAMVVV 188
Cdd:PRK14163 133 QQFG------KEGEPFDPTIHEALMHSYAPDVTETTCVA-ILQPGYRIGERTIRPARVAV 185
PRK14157 PRK14157
heat shock protein GrpE; Provisional
 52-188 5.60e-05

heat shock protein GrpE; Provisional


Pssm-ID: 184543 [Multi-domain]  Cd Length: 227  Bit Score: 42.25  E-value: 5.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  52 ANERADEFENKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERaLAVEGLTDDVKKGLEMTRDSLIQAL 131
Cdd:PRK14157  89 AKKEAAEYLEALQRERAEFINYRNRTQKEQDRFRQHGIIDVLTALLPALDDIDR-IREHSEMDDSFKAVAAKIDKAFEKF 167

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 985376732 132 KEEGVEEVEVDsFDHNFHMAVQTLPaDDEHPADSIAEVFQKGYKLHERLLRPAMVVV 188
Cdd:PRK14157 168 GVEKFGEKGED-FDPTKHDAILHKP-DPDAEKETVDTVVEAGYRIGDRVIRAARVVV 222
PRK14142 PRK14142
heat shock protein GrpE; Provisional
 65-188 2.54e-04

heat shock protein GrpE; Provisional


Pssm-ID: 237623  Cd Length: 223  Bit Score: 40.37  E-value: 2.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985376732  65 RAHAEMQNIQRRSSEERQQlqryrSQDLAKA-----ILPSLDNLERALAVEGLTDDVKKGLEMTRDSLIQALKEEGVEEV 139
Cdd:PRK14142  58 RVQADFANYRKRALRDQQA-----AADRAKAsvvsqLLGVLDDLERARKHGDLESGPLKSVADKLDSALTGLGLVAFGAE 132

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 985376732 140 EVDsFDHNFHMAVQTLPADDEHPADSIAEVFQKGYKLHERLLRPAMVVV 188
Cdd:PRK14142 133 GED-FDPVLHEAVQHEGDGGQGSKPVIGTVMRQGYQLGEQVLRHALVGV 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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