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Conserved domains on  [gi|1008842577|gb|KYK25802|]
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hypothetical protein AYK26_07670 [Euryarchaeota archaeon SM23-78]

Protein Classification

glycosyltransferase family 4 protein( domain architecture ID 10133453)

glycosyltransferase family 4 (GT4) protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

CAZY:  GT4
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  12691742|10521532|16037492
SCOP:  3001586

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 23-369 4.47e-22

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


:

Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 96.07  E-value: 4.47e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577  23 ICQGLAEKGHEIKVAGIRYGGDEHTHDFSIIPCPSI---------QDSLAVIGNLNQVWKFDVLLVALDIPLQREIIREI 93
Cdd:cd03801    23 LARALAARGHDVTVLTPADPGEPPEELEDGVIVPLLpslaallraRRLLRELRPLLRLRKFDVVHAHGLLAALLAALLAL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577  94 AGRIP-------TRDFRYMGIFPIEAdPLIMSWAAILSQMNKAFIISEFGANEARKAGITTAEHLVI---GVDTGAWRPP 163
Cdd:cd03801   103 LLGAPlvvtlhgAEPGRLLLLLAAER-RLLARAEALLRRADAVIAVSEALRDELRALGGIPPEKIVVipnGVDLERFSPP 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 164 TEKERSRFrtaldlEDDFVILTIADNQERKHLSAAFEALEIVDQTHHNFKYLMVTRPdmplGYDLDEL-ALRFGVQDRFM 242
Cdd:cd03801   182 LRRKLGIP------PDRPVLLFVGRLSPRKGVDLLLEALAKLLRRGPDVRLVIVGGD----GPLRAELeELELGLGDRVR 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 243 KFGRgLDYFRLWSLYAASDAFLLTSKAEGLSMPILEAMSVGLPVLATGCTAILDHLEENRGFpidyaykIIDPFGngnry 322
Cdd:cd03801   252 FLGF-VPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVEDGEGG-------LVVPPD----- 318

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1008842577 323 fiDPYSISSVLCGLM-DGKYRHD-KEAALKYIQSRQ-WENTIKQIDDVLQ 369
Cdd:cd03801   319 --DVEALADALLRLLaDPELRARlGRAARERVAERFsWERVAERLLDLYR 366
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 23-369 4.47e-22

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 96.07  E-value: 4.47e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577  23 ICQGLAEKGHEIKVAGIRYGGDEHTHDFSIIPCPSI---------QDSLAVIGNLNQVWKFDVLLVALDIPLQREIIREI 93
Cdd:cd03801    23 LARALAARGHDVTVLTPADPGEPPEELEDGVIVPLLpslaallraRRLLRELRPLLRLRKFDVVHAHGLLAALLAALLAL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577  94 AGRIP-------TRDFRYMGIFPIEAdPLIMSWAAILSQMNKAFIISEFGANEARKAGITTAEHLVI---GVDTGAWRPP 163
Cdd:cd03801   103 LLGAPlvvtlhgAEPGRLLLLLAAER-RLLARAEALLRRADAVIAVSEALRDELRALGGIPPEKIVVipnGVDLERFSPP 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 164 TEKERSRFrtaldlEDDFVILTIADNQERKHLSAAFEALEIVDQTHHNFKYLMVTRPdmplGYDLDEL-ALRFGVQDRFM 242
Cdd:cd03801   182 LRRKLGIP------PDRPVLLFVGRLSPRKGVDLLLEALAKLLRRGPDVRLVIVGGD----GPLRAELeELELGLGDRVR 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 243 KFGRgLDYFRLWSLYAASDAFLLTSKAEGLSMPILEAMSVGLPVLATGCTAILDHLEENRGFpidyaykIIDPFGngnry 322
Cdd:cd03801   252 FLGF-VPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVEDGEGG-------LVVPPD----- 318

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1008842577 323 fiDPYSISSVLCGLM-DGKYRHD-KEAALKYIQSRQ-WENTIKQIDDVLQ 369
Cdd:cd03801   319 --DVEALADALLRLLaDPELRARlGRAARERVAERFsWERVAERLLDLYR 366
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 179-329 6.94e-15

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 71.54  E-value: 6.94e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 179 DDFVILTIADNQERKHLSAAFEALEIVDQTHHNFKYLMVTRPDMPlgYDLDELALRFGVQDRFMKFGRgLDYFRLWSLYA 258
Cdd:pfam00534   1 KKKIILFVGRLEPEKGLDLLIKAFALLKEKNPNLKLVIAGDGEEE--KRLKKLAEKLGLGDNVIFLGF-VSDEDLPELLK 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1008842577 259 ASDAFLLTSKAEGLSMPILEAMSVGLPVLATgctaildhleeNRGFPIDyaykIIDPFGNGnrYFIDPYSI 329
Cdd:pfam00534  78 IADVFVLPSRYEGFGIVLLEAMACGLPVIAS-----------DVGGPPE----VVKDGETG--FLVKPNNA 131
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 246-370 1.17e-13

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 66.94  E-value: 1.17e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 246 RGLDYFrLWSLYAASDAFLLTSKAEGLSMPILEAMSVGLPVLATGCTAILDHLEENR-GFpidyaykIIDPFgngnryfi 324
Cdd:COG0438     8 KGLDLL-LEALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGEtGL-------LVPPG-------- 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1008842577 325 DPYSISSVLCGLMD--GKYRHDKEAALKYIQSR-QWENTIKQIDDVLQE 370
Cdd:COG0438    72 DPEALAEAILRLLEdpELRRRLGEAARERAEERfSWEAIAERLLALYEE 120
stp2 TIGR03088
sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match ...
 256-297 8.82e-07

sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match to the pfam00534 Glycosyl transferases group 1 domain. Nearly all are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria. In particular, these transferases are found proximal to a particular variant of exosortase, EpsH1, which appears to travel with a conserved group of genes summarized by Genome Property GenProp0652. The nature of the sugar transferase reaction catalyzed by members of this clade is unknown and may conceivably be variable with respect to substrate by species, but we hypothesize a conserved substrate.


Pssm-ID: 132132 [Multi-domain]  Cd Length: 374  Bit Score: 50.49  E-value: 8.82e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1008842577 256 LYAASDAFLLTSKAEGLSMPILEAMSVGLPVLAT---GCTAILDH 297
Cdd:TIGR03088 269 LMQALDLFVLPSLAEGISNTILEAMASGLPVIATavgGNPELVQH 313
PRK09922 PRK09922
lipopolysaccharide 1,6-galactosyltransferase;
261-292 3.07e-05

lipopolysaccharide 1,6-galactosyltransferase;


Pssm-ID: 182148 [Multi-domain]  Cd Length: 359  Bit Score: 45.47  E-value: 3.07e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1008842577 261 DAFLLTSKAEGLSMPILEAMSVGLPVLATGCT 292
Cdd:PRK09922  259 SALLLTSKFEGFPMTLLEAMSYGIPCISSDCM 290
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 23-369 4.47e-22

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 96.07  E-value: 4.47e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577  23 ICQGLAEKGHEIKVAGIRYGGDEHTHDFSIIPCPSI---------QDSLAVIGNLNQVWKFDVLLVALDIPLQREIIREI 93
Cdd:cd03801    23 LARALAARGHDVTVLTPADPGEPPEELEDGVIVPLLpslaallraRRLLRELRPLLRLRKFDVVHAHGLLAALLAALLAL 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577  94 AGRIP-------TRDFRYMGIFPIEAdPLIMSWAAILSQMNKAFIISEFGANEARKAGITTAEHLVI---GVDTGAWRPP 163
Cdd:cd03801   103 LLGAPlvvtlhgAEPGRLLLLLAAER-RLLARAEALLRRADAVIAVSEALRDELRALGGIPPEKIVVipnGVDLERFSPP 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 164 TEKERSRFrtaldlEDDFVILTIADNQERKHLSAAFEALEIVDQTHHNFKYLMVTRPdmplGYDLDEL-ALRFGVQDRFM 242
Cdd:cd03801   182 LRRKLGIP------PDRPVLLFVGRLSPRKGVDLLLEALAKLLRRGPDVRLVIVGGD----GPLRAELeELELGLGDRVR 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 243 KFGRgLDYFRLWSLYAASDAFLLTSKAEGLSMPILEAMSVGLPVLATGCTAILDHLEENRGFpidyaykIIDPFGngnry 322
Cdd:cd03801   252 FLGF-VPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGLPVVATDVGGLPEVVEDGEGG-------LVVPPD----- 318

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1008842577 323 fiDPYSISSVLCGLM-DGKYRHD-KEAALKYIQSRQ-WENTIKQIDDVLQ 369
Cdd:cd03801   319 --DVEALADALLRLLaDPELRARlGRAARERVAERFsWERVAERLLDLYR 366
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 19-303 5.54e-18

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 83.95  E-value: 5.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577  19 IIIPICQGLAEKGHEIKVAGIRYGGDEHTH---DFSIIPCPSIQDSLAVIGNLNQVW---------KFDVLLVALDIPlq 86
Cdd:cd03811    17 VLLNLANALDKRGYDVTLVLLRDEGDLDKQlngDVKLIRLLIRVLKLIKLGLLKAILklkrilkraKPDVVISFLGFA-- 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577  87 rEIIREIAGRIPTRDFRYMGIFPIEADPLIMSWAAILS---QMNKAFIISEFGANEARKAGITTAEHLVI---GVDtgaw 160
Cdd:cd03811    95 -TYIVAKLAAARSKVIAWIHSSLSKLYYLKKKLLLKLKlykKADKIVCVSKGIKEDLIRLGPSPPEKIEViynPID---- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 161 rPPTEKERSRFRTALDLEDDFVILTIADNQERKHLSAAFEALEIVDQTHHNFKYLMVTrpDMPLGYDLDELALRFGVQDR 240
Cdd:cd03811   170 -IDRIRALAKEPILNEPEDGPVILAVGRLDPQKGHDLLIEAFAKLRKKYPDVKLVILG--DGPLREELEKLAKELGLAER 246

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1008842577 241 FmKFgRGldyFR--LWSLYAASDAFLLTSKAEGLSMPILEAMSVGLPVLATGCTAILDHLEENRG 303
Cdd:cd03811   247 V-IF-LG---FQsnPYPYLKKADLFVLSSRYEGFPNVLLEAMALGTPVVSTDCPGPREILDDGEN 306
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 114-304 3.26e-16

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 78.90  E-value: 3.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 114 PLIMSWAAILSQMNKAFI-ISEFGANEARKAGITTAEHLVI--GVDTGAWRPpTEKERSRFRTALDL-EDDFVILTIADN 189
Cdd:cd03807   121 RLVRKLCLLLSKFSPATVaNSSAVAEFHQEQGYAKNKIVVIynGIDLFKLSP-DDASRARARRRLGLaEDRRVIGIVGRL 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 190 QERKHLSAAFEALEIVDQTHHNFKYLMVTRPdmPLGYDLDELALRFGVQDRFMKFGRGLDyfrLWSLYAASDAFLLTSKA 269
Cdd:cd03807   200 HPVKDHSDLLRAAALLVETHPDLRLLLVGRG--PERPNLERLLLELGLEDRVHLLGERSD---VPALLPAMDIFVLSSRT 274

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1008842577 270 EGLSMPILEAMSVGLPVLATGCTAILDHLEENRGF 304
Cdd:cd03807   275 EGFPNALLEAMACGLPVVATDVGGAAELVDDGTGF 309
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 179-329 6.94e-15

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 71.54  E-value: 6.94e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 179 DDFVILTIADNQERKHLSAAFEALEIVDQTHHNFKYLMVTRPDMPlgYDLDELALRFGVQDRFMKFGRgLDYFRLWSLYA 258
Cdd:pfam00534   1 KKKIILFVGRLEPEKGLDLLIKAFALLKEKNPNLKLVIAGDGEEE--KRLKKLAEKLGLGDNVIFLGF-VSDEDLPELLK 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1008842577 259 ASDAFLLTSKAEGLSMPILEAMSVGLPVLATgctaildhleeNRGFPIDyaykIIDPFGNGnrYFIDPYSI 329
Cdd:pfam00534  78 IADVFVLPSRYEGFGIVLLEAMACGLPVIAS-----------DVGGPPE----VVKDGETG--FLVKPNNA 131
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 246-370 1.17e-13

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 66.94  E-value: 1.17e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 246 RGLDYFrLWSLYAASDAFLLTSKAEGLSMPILEAMSVGLPVLATGCTAILDHLEENR-GFpidyaykIIDPFgngnryfi 324
Cdd:COG0438     8 KGLDLL-LEALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGEtGL-------LVPPG-------- 71

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1008842577 325 DPYSISSVLCGLMD--GKYRHDKEAALKYIQSR-QWENTIKQIDDVLQE 370
Cdd:COG0438    72 DPEALAEAILRLLEdpELRRRLGEAARERAEERfSWEAIAERLLALYEE 120
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 190-303 4.75e-13

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 68.20  E-value: 4.75e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 190 QERKHLSAAFEALEIVDQTHHNFKYLMVTRPdmPLGYDLDELALRFGVQDRFMKFGRGLDYFRLWSLYAASDAFLLTSKA 269
Cdd:cd01635   120 VPEKGIDLLLEALALLKARLPDLVLVLVGGG--GEREEEEALAAALGLLERVVIIGGLVDDEVLELLLAAADVFVLPSRS 197

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1008842577 270 EGLSMPILEAMSVGLPVLATGCTAILDHLEENRG 303
Cdd:cd01635   198 EGFGLVLLEAMAAGKPVIATDVGGIPEFVVDGEN 231
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 116-303 3.02e-12

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 67.01  E-value: 3.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 116 IMSWAAILSQM-NKAFII---SEFGANEARKAGITTAEhLVI--GVDTGAWRPptekeRSRFRTAL-DLEDDFVILTIAD 188
Cdd:cd03821   139 RIALHLIERRNlNNAALVhftSEQEADELRRFGLEPPI-AVIpnGVDIPEFDP-----GLRDRRKHnGLEDRRIILFLGR 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 189 NQERKHLSAAFEALEIVDQTHHNFKyLMVTRPDMPLGYDLDELALRFGVQDRFMKFGR--GLDyfrLWSLYAASDAFLLT 266
Cdd:cd03821   213 IHPKKGLDLLIRAARKLAEQGRDWH-LVIAGPDDGAYPAFLQLQSSLGLGDRVTFTGPlyGEA---KWALYASADLFVLP 288

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1008842577 267 SKAEGLSMPILEAMSVGLPVLATGCTAILDHLEENRG 303
Cdd:cd03821   289 SYSENFGNVVAEALACGLPVVITDKCGLSELVEAGCG 325
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 24-296 8.12e-12

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 65.76  E-value: 8.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577  24 CQGLAEKGHEIKVAGIRYGGDEHTHDFSIIPCPSIQDSLA-----VIGNLNQV------WKFDVllvaldIPLQREIIRE 92
Cdd:cd03817    24 ARALEKRGHEVYVITPSDPGAEDEEEVVRYRSFSIPIRKYhrqhiPFPFKKAVidrikeLGPDI------IHTHTPFSLG 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577  93 IAG-------RIPT--------RDFRYMGIFPIEADPLIMSW-AAILSQMNKAFII-SEFGANEARKAGITTAEHlVI-- 153
Cdd:cd03817    98 KLGlriarklKIPIvhtyhtmyEDYLHYIPKGKLLVKAVVRKlVRRFYNHTDAVIApSEKIKDTLREYGVKGPIE-VIpn 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 154 GVDTGAW-RPPTEKERSRFRtalDLEDDFVILTIADNQERKHLSAAFEALEIVDqTHHNFKYLMVTrpDMPLGYDLDELA 232
Cdd:cd03817   177 GIDLDKFeKPLNTEERRKLG---LPPDEPILLYVGRLAKEKNIDFLLRAFAELK-KEPNIKLVIVG--DGPEREELKELA 250

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1008842577 233 LRFGVQDRFMKFGRgLDYFRLWSLYAASDAFLLTSKAEGLSMPILEAMSVGLPVLATGCTAILD 296
Cdd:cd03817   251 RELGLADKVIFTGF-VPREELPEYYKAADLFVFASTTETQGLVYLEAMAAGLPVVAAKDPAASE 313
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 132-289 4.05e-11

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 63.54  E-value: 4.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 132 ISEFGANEARKAGITTAEHLVI---GVDtgawRPPTEKERSRFRTALDLEDDFVILTIADNQERKHLSAAFEALEIVDQT 208
Cdd:cd03809   145 VSEATRDDIIKFYGVPPEKIVViplGVD----PSFFPPESAAVLIAKYLLPEPYFLYVGTLEPRKNHERLLKAFALLKKQ 220

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 209 HHNFKYLMVTRPDmPLGYDLDELALRFGVQDRFMKFGRgLDYFRLWSLYAASDAFLLTSKAEGLSMPILEAMSVGLPVLA 288
Cdd:cd03809   221 GGDLKLVIVGGKG-WEDEELLDLVKKLGLGGRVRFLGY-VSDEDLPALYRGARAFVFPSLYEGFGLPVLEAMACGTPVIA 298


                  .
gi 1008842577 289 T 289
Cdd:cd03809   299 S 299
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
253-314 9.96e-11

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 59.06  E-value: 9.96e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1008842577 253 LWSLYAASDAFLLTSKAEGLSMPILEAMSVGLPVLATGCTAILDHLEENRGF------PIDYAYKIID 314
Cdd:pfam13692  67 LAELLAAADVFVLPSLYEGFGLKLLEAMAAGLPVVATDVGGIPELVDGENGLlvppgdPEALAEAILR 134
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 122-297 2.64e-10

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 61.07  E-value: 2.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 122 ILSQMNKAFI-ISEFGANEARKAGITTAEHLVI----GVDTGAWRPPTEKERSrfrtaldleDDFVILTIADNQERKHLS 196
Cdd:cd03808   135 LALLFTDKVIfVNEDDRDLAIKKGIIKKKKTVLipgsGVDLDRFQYSPESLPS---------EKVVFLFVARLLKDKGID 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 197 AAFEALEIVDQTHHNFKYLMVTrpDMPLGYDLDELALRFGVQDRFMKFGRGLDyfrLWSLYAASDAFLLTSKAEGLSMPI 276
Cdd:cd03808   206 ELIEAAKILKKKGPNVRFLLVG--DGELENPSEILIEKLGLEGRIEFLGFRSD---VPELLAESDVFVLPSYREGLPRSL 280

                         170       180
                  ....*....|....*....|....
gi 1008842577 277 LEAMSVGLPVLAT---GCTAILDH 297
Cdd:cd03808   281 LEAMAAGRPVITTdvpGCRELVID 304
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 153-296 4.32e-10

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 60.47  E-value: 4.32e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 153 IGVDTGAWRPPTEkersrfrtALDLEDD-FVILTIADNQERKHLSAAFEALEIVDQTHHNFKYLMVTrpDMPLGYDLDEL 231
Cdd:cd03798   180 NGVDPARFQPEDR--------GLGLPLDaFVILFVGRLIPRKGIDLLLEAFARLAKARPDVVLLIVG--DGPLREALRAL 249

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1008842577 232 ALRFGVQDRFMKFGRgLDYFRLWSLYAASDAFLLTSKAEGLSMPILEAMSVGLPVLATGCTAILD 296
Cdd:cd03798   250 AEDLGLGDRVTFTGR-LPHEQVPAYYRACDVFVLPSRHEGFGLVLLEAMACGLPVVATDVGGIPE 313
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 165-316 3.52e-09

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 57.84  E-value: 3.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 165 EKERSRFRTALDLEDD-FVILTIADNQERKHLSAAFEALEIVDQTHHNFKYLMVTrpDMPLGYDLDELALRFGVQDRFMK 243
Cdd:cd04951   172 INVRLKIRNKLNLKNDeFVILNVGRLTEAKDYPNLLLAISELILSKNDFKLLIAG--DGPLRNELERLICNLNLVDRVIL 249

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1008842577 244 FGRGLDyfrLWSLYAASDAFLLTSKAEGLSMPILEAMSVGLPVLAT---GCTAILDhleenrgfPIDYAYKIIDPF 316
Cdd:cd04951   250 LGQISN---ISEYYNAADLFVLSSEWEGFGLVVAEAMACERPVVATdagGVAEVVG--------DHNYVVPVSDPQ 314
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 154-302 1.68e-08

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 55.44  E-value: 1.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 154 GVDTGAWRPPTEKERSRfRTALDlEDDFVILTIA-DNQERKHLsAAFEALEIVDQTHHnFKYLMVTrpDMPLGYDLDELA 232
Cdd:cd03819   158 GVDTDRFPPEAEAEERA-QLGLP-EGKPVVGYVGrLSPEKGWL-LLVDAAAELKDEPD-FRLLVAG--DGPERDEIRRLV 231

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 233 LRFGVQDRFMKFGRGLDyfrLWSLYAASDAFLLTSKAEGLSMPILEAMSVGLPVLATGCTAILDHLEENR 302
Cdd:cd03819   232 ERLGLRDRVTFTGFRED---VPAALAASDVVVLPSLHEEFGRVALEAMACGTPVVATDVGGAREIVVHGR 298
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 154-322 2.34e-08

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 55.32  E-value: 2.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 154 GVDTGAWRPPTEKERSRFRTALDlEDDFVILTIADNQERKHLSAAFEAL-EIVD-QTHHNFKYLMVTRPDMPLG--YDLD 229
Cdd:cd03800   195 GVDLERFFPVDRAEARRARLLLP-PDKPVVLALGRLDPRKGIDTLVRAFaQLPElRELANLVLVGGPSDDPLSMdrEELA 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 230 ELALRFGVQDRFmKFGRGLDYFRLWSLYAASDAFLLTSKAEGLSMPILEAMSVGLPVLATGCTAILDHLEENR-GF---- 304
Cdd:cd03800   274 ELAEELGLIDRV-RFPGRVSRDDLPELYRAADVFVVPSLYEPFGLTAIEAMACGTPVVATAVGGLQDIVRDGRtGLlvdp 352

                         170       180
                  ....*....|....*....|
gi 1008842577 305 --PIDYAYKIIDPFGNGNRY 322
Cdd:cd03800   353 hdPEALAAALRRLLDDPALW 372
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 137-296 5.92e-08

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 53.87  E-value: 5.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 137 ANEARKAGITT---AEHLVIGVDTGAWRP-PTEKERSRFRTAldlEDDFVILTIADNQE--RKHLSAAFEALEivdqthh 210
Cdd:cd03825   149 ADMVRRSPLLKglpVVVIPNGIDTEIFAPvDKAKARKRLGIP---QDKKVILFGAESVTkpRKGFDELIEALK------- 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 211 nfkyLMVTRPDMPL---GYdLDELALRFGVQdrFMKFGRGLDYFRLWSLYAASDAFLLTSKAEGLSMPILEAMSVGLPVL 287
Cdd:cd03825   219 ----LLATKDDLLLvvfGK-NDPQIVILPFD--IISLGYIDDDEQLVDIYSAADLFVHPSLADNLPNTLLEAMACGTPVV 291


                  ....*....
gi 1008842577 288 ATGCTAILD 296
Cdd:cd03825   292 AFDTGGSPE 300
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 253-291 6.63e-07

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 50.70  E-value: 6.63e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1008842577 253 LWSLYAASDAFLLTSKAEGLSMPILEAMSVGLPVLATGC 291
Cdd:cd03820   249 IAEEYANSSIFVLSSRYEGFPMVLLEAMAYGLPIISFDC 287
stp2 TIGR03088
sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match ...
 256-297 8.82e-07

sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match to the pfam00534 Glycosyl transferases group 1 domain. Nearly all are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria. In particular, these transferases are found proximal to a particular variant of exosortase, EpsH1, which appears to travel with a conserved group of genes summarized by Genome Property GenProp0652. The nature of the sugar transferase reaction catalyzed by members of this clade is unknown and may conceivably be variable with respect to substrate by species, but we hypothesize a conserved substrate.


Pssm-ID: 132132 [Multi-domain]  Cd Length: 374  Bit Score: 50.49  E-value: 8.82e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1008842577 256 LYAASDAFLLTSKAEGLSMPILEAMSVGLPVLAT---GCTAILDH 297
Cdd:TIGR03088 269 LMQALDLFVLPSLAEGISNTILEAMASGLPVIATavgGNPELVQH 313
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 26-289 5.14e-06

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 48.12  E-value: 5.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577  26 GLAEKGHEIKVAG-------IRYGGDEHTHDFSIIPCPSIQD---SLAVIGNLNQV---WKFDVLLVALDIPlqREIIRE 92
Cdd:cd04962    24 ELAERGHEVHFISsaipfrlNLYSGNIFFHEVEVPNYPLFEYppyTLALASKIVEVakeHKLDVLHAHYAIP--HASCAY 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577  93 IAGRIPTRDFRYM------GIFPIEADPL---IMSWAailsqMNKAFII---SEFGANEARKAGITTAEHLVIG--VDTG 158
Cdd:cd04962   102 LAREILGEKIPIVttlhgtDITLVGYDPSlqpAVRFS-----INKSDRVtavSSSLRQETYELFDVDKDIEVIHnfIDED 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 159 AWRPptEKERSRFRTALDLEDDFVILTIADNQERKHLSAAFEALEIVdQTHHNFKYLMVTrpDMPLGYDLDELALRFGVQ 238
Cdd:cd04962   177 VFKR--KPAGALKRRLLAPPDEKVVIHVSNFRPVKRIDDVVRVFARV-RRKIPAKLLLVG--DGPERVPAEELARELGVE 251

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1008842577 239 DRFMKFGrglDYFRLWSLYAASDAFLLTSKAEGLSMPILEAMSVGLPVLAT 289
Cdd:cd04962   252 DRVLFLG---KQDDVEELLSIADLFLLPSEKESFGLAALEAMACGVPVVSS 299
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 118-302 1.51e-05

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 46.52  E-value: 1.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 118 SWAAILS---QMNKAFIISEFGANEARKAGITTAEHLVIGVDTGAWRPpteKERSR-FRTALDLEDDFVILTIAdnqeR- 192
Cdd:cd03814   135 AWAYLRWfhnPFDTTLVPSPSIARELEGHGFERVRLWPRGVDTELFHP---SRRDAaLRRRLGPPGRPLLLYVG----Rl 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 193 ---KHLSAAFEALEIVDQtHHNFKYLMVTrpDMPlgyDLDELALRfGVQDRFMKFGRGLDyfrLWSLYAASDAFLLTSKA 269
Cdd:cd03814   208 apeKNLEALLDADLPLAA-SPPVRLVVVG--DGP---ARAELEAR-GPDVIFTGFLTGEE---LARAYASADVFVFPSRT 277

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1008842577 270 EGLSMPILEAMSVGLPVLATGCTAILDHLEENR 302
Cdd:cd03814   278 ETFGLVVLEAMASGLPVVAADAGGPRDIVRPGG 310
PRK09922 PRK09922
lipopolysaccharide 1,6-galactosyltransferase;
261-292 3.07e-05

lipopolysaccharide 1,6-galactosyltransferase;


Pssm-ID: 182148 [Multi-domain]  Cd Length: 359  Bit Score: 45.47  E-value: 3.07e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1008842577 261 DAFLLTSKAEGLSMPILEAMSVGLPVLATGCT 292
Cdd:PRK09922  259 SALLLTSKFEGFPMTLLEAMSYGIPCISSDCM 290
PRK15179 PRK15179
Vi polysaccharide biosynthesis protein TviE; Provisional
 207-289 2.60e-04

Vi polysaccharide biosynthesis protein TviE; Provisional


Pssm-ID: 185101 [Multi-domain]  Cd Length: 694  Bit Score: 43.10  E-value: 2.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 207 QTHHNFKYLMVTrpDMPLGYDLDELALRFGVQDRFMKFG--RGLDYfrlWslYAASDAFLLTSKAEGLSMPILEAMSVGL 284
Cdd:PRK15179  544 ASHPKVRFIMVG--GGPLLESVREFAQRLGMGERILFTGlsRRVGY---W--LTQFNAFLLLSRFEGLPNVLIEAQFSGV 616


                  ....*
gi 1008842577 285 PVLAT 289
Cdd:PRK15179  617 PVVTT 621
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 137-296 6.26e-04

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 41.62  E-value: 6.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 137 ANEARKAGITTAEHLVI---GVDTGAWRPPTEKERSRFRTALDLEDDFVILTIADNQERKHLSAAFEALEIVDQTHHNFK 213
Cdd:PLN02871  217 GKELEAAGVTAANRIRVwnkGVDSESFHPRFRSEEMRARLSGGEPEKPLIVYVGRLGAEKNLDFLKRVMERLPGARLAFV 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 214 ylmvtrPDMPLGYDLDELalrF-GVQDRFMKFGRGLDyfrLWSLYAASDAFLLTSKAEGLSMPILEAMSVGLPVLATGCT 292
Cdd:PLN02871  297 ------GDGPYREELEKM---FaGTPTVFTGMLQGDE---LSQAYASGDVFVMPSESETLGFVVLEAMASGVPVVAARAG 364


                  ....
gi 1008842577 293 AILD 296
Cdd:PLN02871  365 GIPD 368
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
 107-287 7.63e-04

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 41.12  E-value: 7.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 107 IFPIEADPLIMSWAailsqmNKAFIISEfGANEARKAGITTAEHLVI--GVDTGAWRPPTEKERSRfRTALDLEDDFVIL 184
Cdd:cd03812   124 IRKNVLKKLIERLS------TKYLACSE-DAGEWLFGEVENGKFKVIpnGIDIEKYKFNKEKRRKR-RKLLILEDKLVLG 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 185 TIADNQERKHLSAAFEALEIVDQTHHNFKYLMVTrpDMPLGYDLDELALRFGVQDRfMKF-GRGLDyfrLWSLYAASDAF 263
Cdd:cd03812   196 HVGRFNEQKNHSFLIDIFEELKKKNPNVKLVLVG--EGELKEKIKEKVKELGLEDK-VIFlGFRND---VSEILSAMDVF 269

                         170       180
                  ....*....|....*....|....
gi 1008842577 264 LLTSKAEGLSMPILEAMSVGLPVL 287
Cdd:cd03812   270 LFPSLYEGLPLVAVEAQASGLPCL 293
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 230-289 7.68e-04

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 41.17  E-value: 7.68e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1008842577 230 ELALRFGVQD--RFMKFGRGLDYfrlwslYAASDAFLLTSKAEGLSMPILEAMSVGLPVLAT 289
Cdd:cd03813   345 RLVASLGLENkvKFLGFQNIKEY------YPKLGLLVLTSISEGQPLVILEAMASGVPVVAT 400
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 183-301 8.19e-04

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 40.90  E-value: 8.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 183 ILTIADNQERKHLSAAFEALEIVDQTHHNFKYLMVTrpDMPLGYDLDELA-----------LRFGVQDRFMKFGRGLDYF 251
Cdd:cd03799   177 ILTVGRLTEKKGLEYAIEAVAKLAQKYPNIEYQIIG--DGDLKEQLQQLIqelnigdcvklLGWKPQEEIIEILDEADIF 254

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1008842577 252 RLWSLYAASdaflltSKAEGLSMPILEAMSVGLPVLATGCTAILDHLEEN 301
Cdd:cd03799   255 IAPSVTAAD------GDQDGPPNTLKEAMAMGLPVISTEHGGIPELVEDG 298
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 153-289 1.15e-03

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 40.51  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842577 153 IGVDTGAWRPPTEKERSRfrtaldleddfVILTIADNQERKHLSAAFEALEIVDQTHHNFKYLMVTrpDMPLGYDLDELA 232
Cdd:cd05844   173 IGIDPAKFAPRDPAERAP-----------TILFVGRLVEKKGCDVLIEAFRRLAARHPTARLVIAG--DGPLRPALQALA 239

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1008842577 233 -----LRF-GVQ--DRFMKFGRGLDYFRLWSLYAASdaflltSKAEGLSMPILEAMSVGLPVLAT 289
Cdd:cd05844   240 aalgrVRFlGALphAEVQDWMRRAEIFCLPSVTAAS------GDSEGLGIVLLEAAACGVPVVSS 298
PHA01630 PHA01630
putative group 1 glycosyl transferase
 255-326 2.55e-03

putative group 1 glycosyl transferase


Pssm-ID: 164861  Cd Length: 331  Bit Score: 39.39  E-value: 2.55e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1008842577 255 SLYAASDAFLLTSKAEGLSMPILEAMSVGLPVLATGCTAILDH-LEENRGFPIDYAYKII----DPFGNGnrYFIDP 326
Cdd:PHA01630  205 SLFAGCDILFYPVRGGAFEIPVIEALALGLDVVVTEKGAWSEWvLSNLDVYWIKSGRKPKlwytNPIHVG--YFLDP 279
PHA01633 PHA01633
putative glycosyl transferase group 1
 253-287 6.75e-03

putative glycosyl transferase group 1


Pssm-ID: 107050 [Multi-domain]  Cd Length: 335  Bit Score: 38.04  E-value: 6.75e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1008842577 253 LWSLYAASDAFLLTSKAEGLSMPILEAMSVGLPVL 287
Cdd:PHA01633  217 IFAFYGAMDFTIVPSGTEGFGMPVLESMAMGTPVI 251
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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