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Conserved domains on  [gi|1008842578|gb|KYK25803|]
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hypothetical protein AYK26_07675 [Euryarchaeota archaeon SM23-78]

Protein Classification

glycosyltransferase family protein( domain architecture ID 27718)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_tranf_GTA_type super family cl11394
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 9-198 7.40e-08

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


The actual alignment was detected with superfamily member cd02511:

Pssm-ID: 472172 [Multi-domain]  Cd Length: 229  Bit Score: 51.14  E-value: 7.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842578   9 VRNESKNIERfC--KAYWWVDKILIADGGSEDNTLLLAnqfpnvktENFKVKIYgeNNLWRNpHGRHMNFLFTWAKregA 86
Cdd:cd02511     8 TKNEERNIER-CleSVKWAVDEIIVVDSGSTDRTVEIA--------KEYGAKVY--QRWWDG-FGAQRNFALELAT---N 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842578  87 DWIIFDDCDCVPTTSLQNNARLLFETIKEKLVFAYRLYVYgenqyfprMNDPGK-SIWA-------WRSDLGIYaseKDP 158
Cdd:cd02511    73 DWVLSLDADERLTPELADEILALLATDDYDGYYVPRRNFF--------LGRWIRhGGWYpdrqlrlFRRGKARF---EDG 141

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1008842578 159 WVH-RIEFSYEEPRlelEPPLALLHFFAPNEDEIRRKMNFY 198
Cdd:cd02511   142 RVHeQVVVDGGVGI---VLKGDILHYGYKSLEEFLEKHNRY 179
 
Name Accession Description Interval E-value
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 9-198 7.40e-08

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 51.14  E-value: 7.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842578   9 VRNESKNIERfC--KAYWWVDKILIADGGSEDNTLLLAnqfpnvktENFKVKIYgeNNLWRNpHGRHMNFLFTWAKregA 86
Cdd:cd02511     8 TKNEERNIER-CleSVKWAVDEIIVVDSGSTDRTVEIA--------KEYGAKVY--QRWWDG-FGAQRNFALELAT---N 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842578  87 DWIIFDDCDCVPTTSLQNNARLLFETIKEKLVFAYRLYVYgenqyfprMNDPGK-SIWA-------WRSDLGIYaseKDP 158
Cdd:cd02511    73 DWVLSLDADERLTPELADEILALLATDDYDGYYVPRRNFF--------LGRWIRhGGWYpdrqlrlFRRGKARF---EDG 141

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1008842578 159 WVH-RIEFSYEEPRlelEPPLALLHFFAPNEDEIRRKMNFY 198
Cdd:cd02511   142 RVHeQVVVDGGVGI---VLKGDILHYGYKSLEEFLEKHNRY 179
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 9-131 4.86e-05

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 42.77  E-value: 4.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842578   9 VRNESKNIER----FCKAYWWVDKILIADGGSEDNTLLLANQFPNvKTENFKVkIYGENNLWrnpHGRHMNFLFTWAKre 84
Cdd:COG0463    10 TYNEEEYLEEalesLLAQTYPDFEIIVVDDGSTDGTAEILRELAA-KDPRIRV-IRLERNRG---KGAARNAGLAAAR-- 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1008842578  85 gADWIIFDDCDCVPTTSLQNNARLLFETIKEKLVFAYRLYVYGENQY 131
Cdd:COG0463    83 -GDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGSRLIREGESDL 128
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 3-99 5.78e-05

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 42.00  E-value: 5.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842578   3 IITTTRvrNESKNIERF----CKAYWWVDKILIADGGSEDNTLLLANQFPNvKTENFKVkIYGENNLWrnpHGRHMNFLF 78
Cdd:pfam00535   2 VIIPTY--NEEKYLLETleslLNQTYPNFEIIVVDDGSTDGTVEIAEEYAK-KDPRVRV-IRLPENRG---KAGARNAGL 74

                          90       100
                  ....*....|....*....|.
gi 1008842578  79 TWAKregADWIIFDDCDCVPT 99
Cdd:pfam00535  75 RAAT---GDYIAFLDADDEVP 92
 
Name Accession Description Interval E-value
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 9-198 7.40e-08

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 51.14  E-value: 7.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842578   9 VRNESKNIERfC--KAYWWVDKILIADGGSEDNTLLLAnqfpnvktENFKVKIYgeNNLWRNpHGRHMNFLFTWAKregA 86
Cdd:cd02511     8 TKNEERNIER-CleSVKWAVDEIIVVDSGSTDRTVEIA--------KEYGAKVY--QRWWDG-FGAQRNFALELAT---N 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842578  87 DWIIFDDCDCVPTTSLQNNARLLFETIKEKLVFAYRLYVYgenqyfprMNDPGK-SIWA-------WRSDLGIYaseKDP 158
Cdd:cd02511    73 DWVLSLDADERLTPELADEILALLATDDYDGYYVPRRNFF--------LGRWIRhGGWYpdrqlrlFRRGKARF---EDG 141

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1008842578 159 WVH-RIEFSYEEPRlelEPPLALLHFFAPNEDEIRRKMNFY 198
Cdd:cd02511   142 RVHeQVVVDGGVGI---VLKGDILHYGYKSLEEFLEKHNRY 179
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 3-112 3.20e-05

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 43.76  E-value: 3.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842578   3 IITTtrVRNESKNIERFCKA-----YWWVD-KILIADGGSEDNTLLLANQFPNvktENFKVKIYgeNNLWRN-PHGRHMN 75
Cdd:cd02525     4 IIIP--VRNEEKYIEELLESllnqsYPKDLiEIIVVDGGSTDGTREIVQEYAA---KDPRIRLI--DNPKRIqSAGLNIG 76

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1008842578  76 FlftwaKREGADWIIFDDCDCV-PTTSLQNNARLLFET 112
Cdd:cd02525    77 I-----RNSRGDIIIRVDAHAVyPKDYILELVEALKRT 109
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 9-131 4.86e-05

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 42.77  E-value: 4.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842578   9 VRNESKNIER----FCKAYWWVDKILIADGGSEDNTLLLANQFPNvKTENFKVkIYGENNLWrnpHGRHMNFLFTWAKre 84
Cdd:COG0463    10 TYNEEEYLEEalesLLAQTYPDFEIIVVDDGSTDGTAEILRELAA-KDPRIRV-IRLERNRG---KGAARNAGLAAAR-- 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1008842578  85 gADWIIFDDCDCVPTTSLQNNARLLFETIKEKLVFAYRLYVYGENQY 131
Cdd:COG0463    83 -GDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGSRLIREGESDL 128
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 3-99 5.78e-05

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 42.00  E-value: 5.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842578   3 IITTTRvrNESKNIERF----CKAYWWVDKILIADGGSEDNTLLLANQFPNvKTENFKVkIYGENNLWrnpHGRHMNFLF 78
Cdd:pfam00535   2 VIIPTY--NEEKYLLETleslLNQTYPNFEIIVVDDGSTDGTVEIAEEYAK-KDPRVRV-IRLPENRG---KAGARNAGL 74

                          90       100
                  ....*....|....*....|.
gi 1008842578  79 TWAKregADWIIFDDCDCVPT 99
Cdd:pfam00535  75 RAAT---GDYIAFLDADDEVP 92
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 9-126 8.19e-03

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 35.94  E-value: 8.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842578   9 VRNESKNIER----FCKAYWWVDKILIADGGSEDNTLLLANQFpnVKTENFKVKIYGENNLWrnpHGRHMNFLFTWAKre 84
Cdd:cd00761     5 AYNEEPYLERclesLLAQTYPNFEVIVVDDGSTDGTLEILEEY--AKKDPRVIRVINEENQG---LAAARNAGLKAAR-- 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1008842578  85 gADWIIFDDCDCVPTTS-LQNNARLLFETIKEKLVFAYRLYVY 126
Cdd:cd00761    78 -GEYILFLDADDLLLPDwLERLVAELLADPEADAVGGPGNLLF 119
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 9-98 9.38e-03

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 36.01  E-value: 9.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842578   9 VRNESKNIERFC---KAYWWVDK-ILIADGGSEDNTLLLANQFPnvktenfKVKIYGENNlwRnphGRHMNflfTWAKRE 84
Cdd:cd02522     7 TLNEAENLPRLLaslRRLNPLPLeIIVVDGGSTDGTVAIARSAG-------VVVISSPKG--R---ARQMN---AGAAAA 71

                          90
                  ....*....|....
gi 1008842578  85 GADWIIFDDCDCVP 98
Cdd:cd02522    72 RGDWLLFLHADTRL 85
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 9-98 9.69e-03

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 36.26  E-value: 9.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008842578   9 VRNESKNIERFCKA-----Y-WWVDKILIADGGSEDNTLLLANQFpnvKTENFKVKIYgennlwRNPHGRH----MNFLF 78
Cdd:COG1215    37 AYNEEAVIEETLRSllaqdYpKEKLEVIVVDDGSTDETAEIAREL---AAEYPRVRVI------ERPENGGkaaaLNAGL 107

                          90       100
                  ....*....|....*....|
gi 1008842578  79 TWAKregADWIIFDDCDCVP 98
Cdd:COG1215   108 KAAR---GDIVVFLDADTVL 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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