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Conserved domains on  [gi|1009064305|gb|KYL29668|]
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phosphoglycerate kinase [Mannheimia haemolytica]

Protein Classification

phosphoglycerate kinase( domain architecture ID 10011204)

phosphoglycerate kinase catalyzes the conversion of ATP and 3-phospho-D-glycerate to ADP and 3-phospho-D-glyceroyl phosphate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
pgk PRK00073
phosphoglycerate kinase; Provisional
3-387 0e+00

phosphoglycerate kinase; Provisional


:

Pssm-ID: 234613  Cd Length: 389  Bit Score: 610.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305   3 VIKMTDLDLAGKRLFIRADLNVPVKDGKVTSDARIVATIPTLKLALQKGAKVMVTSHLGRPTeGVFEEeNSLQPVVDYLN 82
Cdd:PRK00073    1 KKTLDDLDLKGKRVLVRVDFNVPVKDGKITDDTRIRAALPTIKYLLEKGAKVILLSHLGRPK-GEDPE-FSLAPVAKRLS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305  83 ASdLGVPVRLVRDYLDG------VEVNENEIVVLENVRINKGEKKNDPELAKKYASLCDVFVMDAFGTAHRAEGSTYGVA 156
Cdd:PRK00073   79 EL-LGKEVKFVDDCIGEeareaiAALKDGEVLLLENVRFNKGEEKNDPELAKKLASLGDVFVNDAFGTAHRAHASTVGIA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 157 EYAPVACAGPLLAAELDALGKALKEPQRPMLAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFIAAEGHAVGKSLYE 236
Cdd:PRK00073  158 KFLKPAAAGFLMEKELEALGKALENPERPFVAILGGAKVSDKIGVLENLLEKVDKLIIGGGMANTFLKAQGYNVGKSLVE 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 237 EDLIPEAKRL-----AQVTNIPVPVDVRVGTEFSEtAPATEKAVSEVRADESIFDIGEKSSEQLAEIIRNSKTILWNGPV 311
Cdd:PRK00073  238 EDLIDTAKELlekakEKGVKIPLPVDVVVAKEFSD-AEATVVSVDEIPDDWMILDIGPKTIELFAEIIKDAKTIVWNGPM 316
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1009064305 312 GVFEFPNFRKGTEVISNAIAEATangAFSIAGGGDTLAAIDLFGIKDKISYISTGGGAFLEFVEGKVLPAVEILEK 387
Cdd:PRK00073  317 GVFEFENFAKGTKAVAKAIAEST---AFSIIGGGDTAAAVEKLGLADKFSHISTGGGASLEFLEGKELPGVAALEE 389
 
Name Accession Description Interval E-value
pgk PRK00073
phosphoglycerate kinase; Provisional
3-387 0e+00

phosphoglycerate kinase; Provisional


Pssm-ID: 234613  Cd Length: 389  Bit Score: 610.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305   3 VIKMTDLDLAGKRLFIRADLNVPVKDGKVTSDARIVATIPTLKLALQKGAKVMVTSHLGRPTeGVFEEeNSLQPVVDYLN 82
Cdd:PRK00073    1 KKTLDDLDLKGKRVLVRVDFNVPVKDGKITDDTRIRAALPTIKYLLEKGAKVILLSHLGRPK-GEDPE-FSLAPVAKRLS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305  83 ASdLGVPVRLVRDYLDG------VEVNENEIVVLENVRINKGEKKNDPELAKKYASLCDVFVMDAFGTAHRAEGSTYGVA 156
Cdd:PRK00073   79 EL-LGKEVKFVDDCIGEeareaiAALKDGEVLLLENVRFNKGEEKNDPELAKKLASLGDVFVNDAFGTAHRAHASTVGIA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 157 EYAPVACAGPLLAAELDALGKALKEPQRPMLAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFIAAEGHAVGKSLYE 236
Cdd:PRK00073  158 KFLKPAAAGFLMEKELEALGKALENPERPFVAILGGAKVSDKIGVLENLLEKVDKLIIGGGMANTFLKAQGYNVGKSLVE 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 237 EDLIPEAKRL-----AQVTNIPVPVDVRVGTEFSEtAPATEKAVSEVRADESIFDIGEKSSEQLAEIIRNSKTILWNGPV 311
Cdd:PRK00073  238 EDLIDTAKELlekakEKGVKIPLPVDVVVAKEFSD-AEATVVSVDEIPDDWMILDIGPKTIELFAEIIKDAKTIVWNGPM 316
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1009064305 312 GVFEFPNFRKGTEVISNAIAEATangAFSIAGGGDTLAAIDLFGIKDKISYISTGGGAFLEFVEGKVLPAVEILEK 387
Cdd:PRK00073  317 GVFEFENFAKGTKAVAKAIAEST---AFSIIGGGDTAAAVEKLGLADKFSHISTGGGASLEFLEGKELPGVAALEE 389
PGK pfam00162
Phosphoglycerate kinase;
13-377 0e+00

Phosphoglycerate kinase;


Pssm-ID: 425495  Cd Length: 370  Bit Score: 520.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305  13 GKRLFIRADLNVPVKD-GKVTSDARIVATIPTLKLALQKGAKVMVTSHLGRPTEGVfeEENSLQPVVDYLnASDLGVPVR 91
Cdd:pfam00162   1 GKRVLVRVDFNVPLDDdGKITDDTRIRAALPTIKYLLEKGAKVILMSHLGRPKGKD--DKFSLKPVAERL-SELLGKPVK 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305  92 LVRDYLDGVEVN------ENEIVVLENVRINKGEKKNDPELAKKYASLCDVFVMDAFGTAHRAEGSTYGVAEYAPvACAG 165
Cdd:pfam00162  78 FADDCIGPEAEAaiaalkPGEVLLLENVRFYKEEEKNDPEFAKKLASLADVYVNDAFGTAHRAHASTVGVAKFLP-SAAG 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 166 PLLAAELDALGKALKEPQRPMLAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFIAAEGHAVGKSLYEEDLIPEAKR 245
Cdd:pfam00162 157 FLMEKELEALSKALENPERPFVAILGGAKVSDKIGVIENLLDKVDKLIIGGGMANTFLKAQGYEIGKSLVEEDKIELAKE 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 246 L-----AQVTNIPVPVDVRVGTEFSetAPATEKAVSEVRADESIFDIGEKSSEQLAEIIRNSKTILWNGPVGVFEFPNFR 320
Cdd:pfam00162 237 LlekakAKGVKIVLPVDVVVADEFS--AEGKVVDVDEIPDDWMGLDIGPETIELFAEVIKKAKTIVWNGPMGVFEFENFA 314
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1009064305 321 KGTEVISNAIAEATAnGAFSIAGGGDTLAAIDLFGIKDKISYISTGGGAFLEFVEGK 377
Cdd:pfam00162 315 KGTKAVAKAIAEATA-GAFSIVGGGDTAAAVEKLGLADKFSHISTGGGASLEFLEGK 370
Pgk COG0126
3-phosphoglycerate kinase [Carbohydrate transport and metabolism]; 3-phosphoglycerate kinase ...
6-388 0e+00

3-phosphoglycerate kinase [Carbohydrate transport and metabolism]; 3-phosphoglycerate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439896  Cd Length: 389  Bit Score: 517.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305   6 MTDLDLAGKRLFIRADLNVPVKDGKVTSDARIVATIPTLKLALQKGAKVMVTSHLGRPtEGVFEEENSLQPVVDYLnASD 85
Cdd:COG0126     2 LDDLDLKGKRVLVRVDFNVPLDDGKITDDTRIRAALPTIKYLLEKGAKVILLSHLGRP-KGKVDPKYSLKPVAERL-SEL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305  86 LGVPVRLVRDyLDGVEV-------NENEIVVLENVRINKGEKKNDPELAKKYASLCDVFVMDAFGTAHRAEGSTYGVAEY 158
Cdd:COG0126    80 LGKPVKFVDD-CIGEEAeaavaalKPGEVLLLENLRFHPEEEKNDPEFAKKLASLGDVYVNDAFGTAHRAHASTVGIAKL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 159 APvACAGPLLAAELDALGKALKEPQRPMLAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFIAAEGHAVGKSLYEED 238
Cdd:COG0126   159 LP-SAAGFLMEKELEALGKALENPERPFVAILGGAKVSDKIGVIENLLEKVDKLLIGGGMANTFLKAQGYDVGKSLVEED 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 239 LIPEAKRL-----AQVTNIPVPVDVRVGTEFSETAPATEKAVSEVRADESIFDIGEKSSEQLAEIIRNSKTILWNGPVGV 313
Cdd:COG0126   238 KIDTAKEIlekakEKGVKIVLPVDVVVADEFSADAERKVVPVDEIPDDWMGLDIGPKTIELFAEVIKDAKTVVWNGPMGV 317
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1009064305 314 FEFPNFRKGTEVISNAIAEAtanGAFSIAGGGDTLAAIDLFGIKDKISYISTGGGAFLEFVEGKVLPAVEILEKR 388
Cdd:COG0126   318 FEMEPFAKGTRAVAKAIAES---GAFSVVGGGDTAAAVNKLGLADKFSHVSTGGGASLEFLEGKELPGVEALEDK 389
Phosphoglycerate_kinase cd00318
Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the ...
6-386 2.11e-174

Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level phosphorylation events in the glycolytic pathway. Substrate-level phosphorylation is defined as production of ATP by a process, which is catalyzed by water-soluble enzymes in the cytosol; not involving membranes and ion gradients.


Pssm-ID: 238195  Cd Length: 397  Bit Score: 491.77  E-value: 2.11e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305   6 MTDLDLAGKRLFIRADLNVPVKDGKVTSDARIVATIPTLKLALQKGAKVMVTSHLGRPTeGVFEEENSLQPVVDYLnASD 85
Cdd:cd00318     1 IDDLDLKGKRVLVRVDFNVPVDDGKITDDTRIRAALPTIKYLLEQGAKVVLLSHLGRPK-GEPNEKYSLAPVAKAL-SEL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305  86 LGVPVRLVRDYLdGVEV-------NENEIVVLENVRINKGEKKN-------DPELAKKYASLCDVFVMDAFGTAHRAEGS 151
Cdd:cd00318    79 LGQPVTFANDCV-GPEAeeavealKPGDVLLLENVRFYPEEEGKrdddkeaDEEFAKKLASLGDVYVNDAFGTAHRAHAS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 152 TYGVAEYaPVACAGPLLAAELDALGKALKEPQRPMLAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFIAAEGHAVG 231
Cdd:cd00318   158 MVGIALL-LPSAAGFLMEKELKYLAKALENPERPFVAILGGAKVSDKIQVIENLLDKVDYLIIGGGMAFTFLKAQGMDIG 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 232 KSLYEEDLIPEAKRL---AQVTN--IPVPVDVRVGTEFSETAPATEKAVSEVRADESIFDIGEKSSEQLAEIIRNSKTIL 306
Cdd:cd00318   237 KSLFEEDGIELAKSLlekAKAKGvkIVLPVDVVVADKFKADANTKVVTDDGIPDGWMGLDIGPKTIELFAEVIRKAKTIV 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 307 WNGPVGVFEFPNFRKGTEVISNAIAEATANGAFSIAGGGDTLAAIDLFGIKDKISYISTGGGAFLEFVEGKVLPAVEILE 386
Cdd:cd00318   317 WNGPMGVFEFPAFAKGTKAIADAIAAATKAGAFSIIGGGDTAAAAEKFGLADKISHVSTGGGASLELLEGKELPGVAALE 396
 
Name Accession Description Interval E-value
pgk PRK00073
phosphoglycerate kinase; Provisional
3-387 0e+00

phosphoglycerate kinase; Provisional


Pssm-ID: 234613  Cd Length: 389  Bit Score: 610.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305   3 VIKMTDLDLAGKRLFIRADLNVPVKDGKVTSDARIVATIPTLKLALQKGAKVMVTSHLGRPTeGVFEEeNSLQPVVDYLN 82
Cdd:PRK00073    1 KKTLDDLDLKGKRVLVRVDFNVPVKDGKITDDTRIRAALPTIKYLLEKGAKVILLSHLGRPK-GEDPE-FSLAPVAKRLS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305  83 ASdLGVPVRLVRDYLDG------VEVNENEIVVLENVRINKGEKKNDPELAKKYASLCDVFVMDAFGTAHRAEGSTYGVA 156
Cdd:PRK00073   79 EL-LGKEVKFVDDCIGEeareaiAALKDGEVLLLENVRFNKGEEKNDPELAKKLASLGDVFVNDAFGTAHRAHASTVGIA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 157 EYAPVACAGPLLAAELDALGKALKEPQRPMLAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFIAAEGHAVGKSLYE 236
Cdd:PRK00073  158 KFLKPAAAGFLMEKELEALGKALENPERPFVAILGGAKVSDKIGVLENLLEKVDKLIIGGGMANTFLKAQGYNVGKSLVE 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 237 EDLIPEAKRL-----AQVTNIPVPVDVRVGTEFSEtAPATEKAVSEVRADESIFDIGEKSSEQLAEIIRNSKTILWNGPV 311
Cdd:PRK00073  238 EDLIDTAKELlekakEKGVKIPLPVDVVVAKEFSD-AEATVVSVDEIPDDWMILDIGPKTIELFAEIIKDAKTIVWNGPM 316
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1009064305 312 GVFEFPNFRKGTEVISNAIAEATangAFSIAGGGDTLAAIDLFGIKDKISYISTGGGAFLEFVEGKVLPAVEILEK 387
Cdd:PRK00073  317 GVFEFENFAKGTKAVAKAIAEST---AFSIIGGGDTAAAVEKLGLADKFSHISTGGGASLEFLEGKELPGVAALEE 389
PGK pfam00162
Phosphoglycerate kinase;
13-377 0e+00

Phosphoglycerate kinase;


Pssm-ID: 425495  Cd Length: 370  Bit Score: 520.77  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305  13 GKRLFIRADLNVPVKD-GKVTSDARIVATIPTLKLALQKGAKVMVTSHLGRPTEGVfeEENSLQPVVDYLnASDLGVPVR 91
Cdd:pfam00162   1 GKRVLVRVDFNVPLDDdGKITDDTRIRAALPTIKYLLEKGAKVILMSHLGRPKGKD--DKFSLKPVAERL-SELLGKPVK 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305  92 LVRDYLDGVEVN------ENEIVVLENVRINKGEKKNDPELAKKYASLCDVFVMDAFGTAHRAEGSTYGVAEYAPvACAG 165
Cdd:pfam00162  78 FADDCIGPEAEAaiaalkPGEVLLLENVRFYKEEEKNDPEFAKKLASLADVYVNDAFGTAHRAHASTVGVAKFLP-SAAG 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 166 PLLAAELDALGKALKEPQRPMLAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFIAAEGHAVGKSLYEEDLIPEAKR 245
Cdd:pfam00162 157 FLMEKELEALSKALENPERPFVAILGGAKVSDKIGVIENLLDKVDKLIIGGGMANTFLKAQGYEIGKSLVEEDKIELAKE 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 246 L-----AQVTNIPVPVDVRVGTEFSetAPATEKAVSEVRADESIFDIGEKSSEQLAEIIRNSKTILWNGPVGVFEFPNFR 320
Cdd:pfam00162 237 LlekakAKGVKIVLPVDVVVADEFS--AEGKVVDVDEIPDDWMGLDIGPETIELFAEVIKKAKTIVWNGPMGVFEFENFA 314
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1009064305 321 KGTEVISNAIAEATAnGAFSIAGGGDTLAAIDLFGIKDKISYISTGGGAFLEFVEGK 377
Cdd:pfam00162 315 KGTKAVAKAIAEATA-GAFSIVGGGDTAAAVEKLGLADKFSHISTGGGASLEFLEGK 370
Pgk COG0126
3-phosphoglycerate kinase [Carbohydrate transport and metabolism]; 3-phosphoglycerate kinase ...
6-388 0e+00

3-phosphoglycerate kinase [Carbohydrate transport and metabolism]; 3-phosphoglycerate kinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439896  Cd Length: 389  Bit Score: 517.65  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305   6 MTDLDLAGKRLFIRADLNVPVKDGKVTSDARIVATIPTLKLALQKGAKVMVTSHLGRPtEGVFEEENSLQPVVDYLnASD 85
Cdd:COG0126     2 LDDLDLKGKRVLVRVDFNVPLDDGKITDDTRIRAALPTIKYLLEKGAKVILLSHLGRP-KGKVDPKYSLKPVAERL-SEL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305  86 LGVPVRLVRDyLDGVEV-------NENEIVVLENVRINKGEKKNDPELAKKYASLCDVFVMDAFGTAHRAEGSTYGVAEY 158
Cdd:COG0126    80 LGKPVKFVDD-CIGEEAeaavaalKPGEVLLLENLRFHPEEEKNDPEFAKKLASLGDVYVNDAFGTAHRAHASTVGIAKL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 159 APvACAGPLLAAELDALGKALKEPQRPMLAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFIAAEGHAVGKSLYEED 238
Cdd:COG0126   159 LP-SAAGFLMEKELEALGKALENPERPFVAILGGAKVSDKIGVIENLLEKVDKLLIGGGMANTFLKAQGYDVGKSLVEED 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 239 LIPEAKRL-----AQVTNIPVPVDVRVGTEFSETAPATEKAVSEVRADESIFDIGEKSSEQLAEIIRNSKTILWNGPVGV 313
Cdd:COG0126   238 KIDTAKEIlekakEKGVKIVLPVDVVVADEFSADAERKVVPVDEIPDDWMGLDIGPKTIELFAEVIKDAKTVVWNGPMGV 317
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1009064305 314 FEFPNFRKGTEVISNAIAEAtanGAFSIAGGGDTLAAIDLFGIKDKISYISTGGGAFLEFVEGKVLPAVEILEKR 388
Cdd:COG0126   318 FEMEPFAKGTRAVAKAIAES---GAFSVVGGGDTAAAVNKLGLADKFSHVSTGGGASLEFLEGKELPGVEALEDK 389
Phosphoglycerate_kinase cd00318
Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the ...
6-386 2.11e-174

Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level phosphorylation events in the glycolytic pathway. Substrate-level phosphorylation is defined as production of ATP by a process, which is catalyzed by water-soluble enzymes in the cytosol; not involving membranes and ion gradients.


Pssm-ID: 238195  Cd Length: 397  Bit Score: 491.77  E-value: 2.11e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305   6 MTDLDLAGKRLFIRADLNVPVKDGKVTSDARIVATIPTLKLALQKGAKVMVTSHLGRPTeGVFEEENSLQPVVDYLnASD 85
Cdd:cd00318     1 IDDLDLKGKRVLVRVDFNVPVDDGKITDDTRIRAALPTIKYLLEQGAKVVLLSHLGRPK-GEPNEKYSLAPVAKAL-SEL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305  86 LGVPVRLVRDYLdGVEV-------NENEIVVLENVRINKGEKKN-------DPELAKKYASLCDVFVMDAFGTAHRAEGS 151
Cdd:cd00318    79 LGQPVTFANDCV-GPEAeeavealKPGDVLLLENVRFYPEEEGKrdddkeaDEEFAKKLASLGDVYVNDAFGTAHRAHAS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 152 TYGVAEYaPVACAGPLLAAELDALGKALKEPQRPMLAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFIAAEGHAVG 231
Cdd:cd00318   158 MVGIALL-LPSAAGFLMEKELKYLAKALENPERPFVAILGGAKVSDKIQVIENLLDKVDYLIIGGGMAFTFLKAQGMDIG 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 232 KSLYEEDLIPEAKRL---AQVTN--IPVPVDVRVGTEFSETAPATEKAVSEVRADESIFDIGEKSSEQLAEIIRNSKTIL 306
Cdd:cd00318   237 KSLFEEDGIELAKSLlekAKAKGvkIVLPVDVVVADKFKADANTKVVTDDGIPDGWMGLDIGPKTIELFAEVIRKAKTIV 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 307 WNGPVGVFEFPNFRKGTEVISNAIAEATANGAFSIAGGGDTLAAIDLFGIKDKISYISTGGGAFLEFVEGKVLPAVEILE 386
Cdd:cd00318   317 WNGPMGVFEFPAFAKGTKAIADAIAAATKAGAFSIIGGGDTAAAAEKFGLADKISHVSTGGGASLELLEGKELPGVAALE 396
PRK13962 PRK13962
bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional
8-390 2.06e-132

bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional


Pssm-ID: 237572 [Multi-domain]  Cd Length: 645  Bit Score: 393.71  E-value: 2.06e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305   8 DLDLAGKRLFIRADLNVPVK-DGKVTSDARIVATIPTLKLALQKGAKVMVTSHLGRPtEGVFEEENSLQPVVDYLnASDL 86
Cdd:PRK13962    8 DIDVKGKRVIVRVDFNVPLDeNGNITDDTRIRAALPTIKYLLDHGAKVILVSHLGRP-KGEFDPKFSMAPVAKRL-SELL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305  87 GVPVRLVRDYLdGVEV-------NENEIVVLENVRINKGEKKNDPELAKKYASLCDVFVMDAFGTAHRAEGSTYGVAEYA 159
Cdd:PRK13962   86 GKEVIFAKDVI-GDDAkkavaqlKEGDVLLLENVRFHKEETKNDPEFAKELASLADIYVNDAFGTAHRAHASTAGVAEYL 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 160 PVACaGPLLAAELDALGKALKEPQRPMLAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFIAAEGHAVGKSLYEEDL 239
Cdd:PRK13962  165 PAVA-GFLMEKEIEFLGKALANPQRPFVAILGGAKVSDKIGVIENLLEKVDKLLIGGGMAYTFLKAKGYEVGKSLVEEDK 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 240 IPEAKRL-----AQVTNIPVPVDVRVGTEFSETAPATEKAVSEVRADESIFDIGEKSSEQLAEIIRNSKTILWNGPVGVF 314
Cdd:PRK13962  244 LDLAKELlakaeEKGVKLLLPVDSVVAKEFKNDAEHKVVPSDAIPEDWMGLDIGPETIELFAKKIADAKTIVWNGPMGVF 323
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1009064305 315 EFPNFRKGTEVISNAIAEataNGAFSIAGGGDTLAAIDLFGIKDKISYISTGGGAFLEFVEGKVLPAVEILEKRAN 390
Cdd:PRK13962  324 EFDNFAEGTRAVAEAVAE---SGAITIIGGGDSAAAVEKLGFADKMSHISTGGGASLEFLEGKVLPGIACLLDKNP 396
PLN02282 PLN02282
phosphoglycerate kinase
2-386 4.38e-111

phosphoglycerate kinase


Pssm-ID: 165923  Cd Length: 401  Bit Score: 330.78  E-value: 4.38e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305   2 SVIKMTDLDLAGKRLFIRADLNVPVKDG-KVTSDARIVATIPTLKLALQKGAKVMVTSHLGRPtEGVfEEENSLQPVVDY 80
Cdd:PLN02282    6 SVGTLKEADLKGKRVFVRVDLNVPLDDNsNITDDTRIRAAVPTIKYLMGHGARVILCSHLGRP-KGV-TPKYSLKPLVPR 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305  81 LnASDLGVPVRLVRDYLdGVEVN-------ENEIVVLENVRINKGEKKNDPELAKKYASLCDVFVMDAFGTAHRAEGSTY 153
Cdd:PLN02282   84 L-SELLGVEVVMANDCI-GEEVEklvaelpEGGVLLLENVRFYKEEEKNDPEFAKKLASLADVYVNDAFGTAHRAHASTE 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 154 GVAEYAPVACAGPLLAAELDALGKALKEPQRPMLAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFIAAEGHAVGKS 233
Cdd:PLN02282  162 GVAKYLKPSVAGFLMQKELDYLVGAVANPKKPFAAIVGGSKVSTKIGVIESLLEKVDILLLGGGMIFTFYKAQGYSVGSS 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 234 LYEEDLIPEAKRL-----AQVTNIPVPVDVRVGTEFSETAPATEKAVSEVRADESIFDIGEKSSEQLAEIIRNSKTILWN 308
Cdd:PLN02282  242 LVEEDKLDLATSLiekakAKGVSLLLPTDVVIADKFAPDANSKVVPASAIPDGWMGLDIGPDSIKTFSEALDTTKTIIWN 321
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1009064305 309 GPVGVFEFPNFRKGTEVISNAIAEATANGAFSIAGGGDTLAAIDLFGIKDKISYISTGGGAFLEFVEGKVLPAVEILE 386
Cdd:PLN02282  322 GPMGVFEFEKFAAGTEAIAKKLAELSGKGVTTIIGGGDSVAAVEKVGLADKMSHISTGGGASLELLEGKPLPGVLALD 399
PTZ00005 PTZ00005
phosphoglycerate kinase; Provisional
4-385 1.20e-109

phosphoglycerate kinase; Provisional


Pssm-ID: 173310  Cd Length: 417  Bit Score: 327.80  E-value: 1.20e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305   4 IKMTDLDLAGKRLFIRADLNVPVKDGKVTSDARIVATIPTLKLALQKGAK-VMVTSHLGRPtEGVFEEENSLQPVVDYLN 82
Cdd:PTZ00005    8 IDDVDDQLKGKRVLIRVDFNVPIKEGVIKDATRIKATLPTIKYLLEQGAKsVVLMSHLGRP-DGRRVEKYSLKPVVPKLE 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305  83 aSDLGVPVRLVRDYLdGVEVNE-------NEIVVLENVRINKGEK-----------KNDPELAKKY----ASLCDVFVMD 140
Cdd:PTZ00005   87 -ELLGKKVTFLNDCV-GPEVEEacanaknGSVILLENLRFHIEEEgkgvdangnkvKADKEEVKKFrkslTKLGDIYVND 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 141 AFGTAHRAEGSTYGVAeyAPVACAGPLLAAELDALGKALKEPQRPMLAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIAN 220
Cdd:PTZ00005  165 AFGTAHRAHSSMVGVD--LPVKVAGFLMKKELDYFSKALENPQRPFLAILGGAKVADKIQLIKNLLDKVDEMIIGGGMAF 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 221 TFIAA-EGHAVGKSLYEED---LIPEAKRLAQVTNIPV--PVDVRVGTEFSETAPAteKAVSEvraDESI------FDIG 288
Cdd:PTZ00005  243 TFKKVlDNMPIGKSLFDEEgakIVKEIMEKAKEKNVKIhlPVDFVCADKFDNNANT--KVVTD---KEGIpdgwmgLDAG 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 289 EKSSEQLAEIIRNSKTILWNGPVGVFEFPNFRKGTEVISNAIAEATANGAFSIAGGGDTLAAIDLFGIKDKISYISTGGG 368
Cdd:PTZ00005  318 PKSIEEFAEAILRAKTIVWNGPQGVFEMPNFAKGSIAMLDAVVKATEKGAITIVGGGDTASLVEKTGAANKVSHVSTGGG 397
                         410
                  ....*....|....*..
gi 1009064305 369 AFLEFVEGKVLPAVEIL 385
Cdd:PTZ00005  398 ASLELLEGKELPGVVAL 414
PLN03034 PLN03034
phosphoglycerate kinase; Provisional
2-387 3.99e-105

phosphoglycerate kinase; Provisional


Pssm-ID: 178602 [Multi-domain]  Cd Length: 481  Bit Score: 318.48  E-value: 3.99e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305   2 SVIKMTDLDLAGKRLFIRADLNVPVKDG-KVTSDARIVATIPTLKLALQKGAKVMVTSHLGRPtEGVfEEENSLQPVVDY 80
Cdd:PLN03034   81 SVGDLTSADLKGKKVFVRADLNVPLDDNqNITDDTRIRAAIPTIKYLISNGAKVILSSHLGRP-KGV-TPKFSLAPLVPR 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305  81 LnASDLGVPVRLVRDYLdGVEVN-------ENEIVVLENVRINKGEKKNDPELAKKYASLCDVFVMDAFGTAHRAEGSTY 153
Cdd:PLN03034  159 L-SELLGIQVVKADDCI-GPEVEklvaslpEGGVLLLENVRFYKEEEKNEPEFAKKLASLADLYVNDAFGTAHRAHASTE 236
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 154 GVAEYAPVACAGPLLAAELDALGKALKEPQRPMLAIVGGSKVSTKLTVLDSLSKIADQLIVGGGIANTFIAAEGHAVGKS 233
Cdd:PLN03034  237 GVTKFLKPSVAGFLLQKELDYLVGAVSNPKRPFAAIVGGSKVSSKIGVIESLLEKCDILLLGGGMIFTFYKAQGLSVGSS 316
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009064305 234 LYEEDLIPEAKRL-----AQVTNIPVPVDVRVGTEFSETAPATEKAVSEVRADESIFDIGEKSSEQLAEIIRNSKTILWN 308
Cdd:PLN03034  317 LVEEDKLELATSLlakakAKGVSLLLPTDVVIADKFAPDANSKIVPASAIPDGWMGLDIGPDSVKTFNEALDTTQTVIWN 396
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1009064305 309 GPVGVFEFPNFRKGTEVISNAIAEATANGAFSIAGGGDTLAAIDLFGIKDKISYISTGGGAFLEFVEGKVLPAVEILEK 387
Cdd:PLN03034  397 GPMGVFEFEKFAVGTEAVAKKLAELSGKGVTTIIGGGDSVAAVEKVGVADVMSHISTGGGASLELLEGKELPGVVALDE 475
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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