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Conserved domains on  [gi|1013840332|gb|KYQ79906|]
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3-isopropylmalate dehydrogenase [Acinetobacter lactucae]

Protein Classification

3-isopropylmalate dehydrogenase( domain architecture ID 10011514)

3-isopropylmalate dehydrogenase catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate

CATH:  3.40.718.10
EC:  1.1.1.85
Gene Symbol:  leuB
Gene Ontology:  GO:0003862|GO:0046872|GO:0051287
SCOP:  4000791

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 1-359 0e+00

3-isopropylmalate dehydrogenase; Provisional


:

Pssm-ID: 234832  Cd Length: 358  Bit Score: 677.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332   1 MSKQILILAGDGIGPEIVGAAEKVLNTVNEKFNLSLTWEHGLLGGAAIDAHGEPYPAVTSEQAKKADAILLGAVGGPKWD 80
Cdd:PRK00772    1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  81 TIERSIRPERGLLKIRSELNLFANLRPAILYPQLADASSLKPEIVAGLDILIVRELTGGIYFGQPRGIRElENGEKQGYN 160
Cdd:PRK00772   81 NLPPDVRPERGLLALRKELGLFANLRPAKLYPGLADASPLKPEIVAGLDILIVRELTGGIYFGEPRGREG-LGGEERAFD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 161 TDVYSESEIKRIAKVAFELAGLRGGKVCSVDKANVLEVTELWKQTVTDLQQaNYSNIQLSHMYVDNAAMQLVRAPKQFDV 240
Cdd:PRK00772  160 TMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAK-EYPDVELSHMYVDNAAMQLVRNPKQFDV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 241 IVTGNLFGDILSDEAAMLTGSIGMLPSASLDENGKGMYEPCHGSAPDIAGQNVANPLATILSVAMMLRYTFREEAAAKAI 320
Cdd:PRK00772  239 IVTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAI 318

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1013840332 321 EDAVGQVLDQGLRTADIMsEGMTKVGTAEMGEAVVAALA 359
Cdd:PRK00772  319 EAAVEKVLAQGYRTADIA-EGGGKVSTSEMGDAILAALA 356
 
Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 1-359 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 677.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332   1 MSKQILILAGDGIGPEIVGAAEKVLNTVNEKFNLSLTWEHGLLGGAAIDAHGEPYPAVTSEQAKKADAILLGAVGGPKWD 80
Cdd:PRK00772    1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  81 TIERSIRPERGLLKIRSELNLFANLRPAILYPQLADASSLKPEIVAGLDILIVRELTGGIYFGQPRGIRElENGEKQGYN 160
Cdd:PRK00772   81 NLPPDVRPERGLLALRKELGLFANLRPAKLYPGLADASPLKPEIVAGLDILIVRELTGGIYFGEPRGREG-LGGEERAFD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 161 TDVYSESEIKRIAKVAFELAGLRGGKVCSVDKANVLEVTELWKQTVTDLQQaNYSNIQLSHMYVDNAAMQLVRAPKQFDV 240
Cdd:PRK00772  160 TMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAK-EYPDVELSHMYVDNAAMQLVRNPKQFDV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 241 IVTGNLFGDILSDEAAMLTGSIGMLPSASLDENGKGMYEPCHGSAPDIAGQNVANPLATILSVAMMLRYTFREEAAAKAI 320
Cdd:PRK00772  239 IVTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAI 318

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1013840332 321 EDAVGQVLDQGLRTADIMsEGMTKVGTAEMGEAVVAALA 359
Cdd:PRK00772  319 EAAVEKVLAQGYRTADIA-EGGGKVSTSEMGDAILAALA 356
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 2-358 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 572.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332   2 SKQILILAGDGIGPEIVGAAEKVLNTVNEKFNLSLTWEHGLLGGAAIDAHGEPYPAVTSEQAKKADAILLGAVGGPKWDt 81
Cdd:COG0473     1 TYKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWD- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  82 ieRSIRPERGLLKIRSELNLFANLRPAILYPQLAdaSSLKPEIVAGLDILIVRELTGGIYFGQPRGIRElENGEKQGYNT 161
Cdd:COG0473    80 --DGVRPESGLLALRKELDLYANLRPAKLYPGLP--SPLKPEIVEGIDLVIVRENTEGLYFGIGGRIGT-GTGEEVAIDT 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 162 DVYSESEIKRIAKVAFELAGLRGGKVCSVDKANVLEVT-ELWKQTVTDLQqANYSNIQLSHMYVDNAAMQLVRAPKQFDV 240
Cdd:COG0473   155 RVYTRKGIERIARYAFELARKRRKKVTSVDKANVLKLTsGLWREVVREVA-KEYPDVELDHMYVDAAAMQLVRNPEQFDV 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 241 IVTGNLFGDILSDEAAMLTGSIGMLPSASLDENGKGMYEPCHGSAPDIAGQNVANPLATILSVAMMLRYtFREEAAAKAI 320
Cdd:COG0473   234 IVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRH-LGEEEAADAI 312

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1013840332 321 EDAVGQVLDQGLRTADIMSegmtKVGTAEMGEAVVAAL 358
Cdd:COG0473   313 EAAVEKVLAEGVRTPDLGG----KAGTSEMGDAIIAAL 346
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 5-354 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 533.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332   5 ILILAGDGIGPEIVGAAEKVLNTVNEKFNLSLTWEHGLLGGAAIDAHGEPYPAVTSEQAKKADAILLGAVGGPKWDTIER 84
Cdd:TIGR00169   2 IAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLPR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  85 SIRPERGLLKIRSELNLFANLRPAILYPQLADASSLKPEIVAGLDILIVRELTGGIYFGQPRGIreleNGEKQGYNTDVY 164
Cdd:TIGR00169  82 DQRPEQGLLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGR----EGEGEAWDTEVY 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 165 SESEIKRIAKVAFELAGLRGGKVCSVDKANVLEVTELWKQTVTDLQQaNYSNIQLSHMYVDNAAMQLVRAPKQFDVIVTG 244
Cdd:TIGR00169 158 TVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAK-EYPDVELEHQYIDNAAMQLVKSPTQFDVVVTS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 245 NLFGDILSDEAAMLTGSIGMLPSASLDENGKGMYEPCHGSAPDIAGQNVANPLATILSVAMMLRYTFREEAAAKAIEDAV 324
Cdd:TIGR00169 237 NLFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAAV 316

                         330       340       350
                  ....*....|....*....|....*....|
gi 1013840332 325 GQVLDQGLRTADIMSEGMTKVGTAEMGEAV 354
Cdd:TIGR00169 317 KKVLAEGYRTPDLGSSATTAVGTAEMGEEL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
5-354 0e+00

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 505.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332   5 ILILAGDGIGPEIVGAAEKVLNTVNEKFNLSLTWEHGLLGGAAIDAHGEPYPAVTSEQAKKADAILLGAVGGPKWDtiER 84
Cdd:pfam00180   2 IAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWD--PA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  85 SIRPERGLLKIRSELNLFANLRPAILYPQLADASSLKPEiVAGLDILIVRELTGGIYFGQPRGIREleNGEKQGYNTDVY 164
Cdd:pfam00180  80 GVRPENGLLALRKELGLFANLRPAKVFPPLGDASPLKNE-VEGVDIVIVRELTGGIYFGIEKGIKG--SGNEVAVDTKLY 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 165 SESEIKRIAKVAFELAGLRG-GKVCSVDKANVLEVTELWKQTVTDLQQANYSNIQLSHMYVDNAAMQLVRAPKQFDVIVT 243
Cdd:pfam00180 157 SRDEIERIARVAFELARKRGrKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVT 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 244 GNLFGDILSDEAAMLTGSIGMLPSASLDENGKGMYEPCHGSAPDIAGQNVANPLATILSVAMMLRYTFREEAAAKAIEDA 323
Cdd:pfam00180 237 PNLFGDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIEAA 316

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1013840332 324 VGQVLDQGLRTADIMSEgMTKVGTAEMGEAV 354
Cdd:pfam00180 317 VLKVLESGIRTGDLAGS-ATYVSTSEFGEAV 346
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
3-355 1.59e-79

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 246.57  E-value: 1.59e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332   3 KQILILAGDGIGPEIVGAAEKVLntvnEKFNLSLTWEHGLLGGAAIDAHGEPYPAVTSEQAKKADAILLGAVggpkwdti 82
Cdd:NF040626    2 YKITVIPGDGIGKEVMEAALYVL----DALDLNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAV-------- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  83 eRSIRPER-GLLKIRSELNLFANLRPAILYPQLadasslkPEIVAGLDILIVRELTGGIYFGQprgirELENGEKQGYNT 161
Cdd:NF040626   70 -TSTPGQKsPIITLRKELDLYANLRPIKSYEGI-------NCLFKDLDFLIVRENTEGLYSGL-----EEEYTEEKAIAE 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 162 DVYSESEIKRIAKVAFELAGLRG-GKVCSVDKANVLEVTE-LWKQTVTDLQQaNYSNIQLSHMYVDNAAMQLVRAPKQFD 239
Cdd:NF040626  137 RVITRKASERICKFAFEYAIKLGrKKVTAVHKANVLKKTDgIFKDTFYKVAK-DYPQIETEDYYVDATAMYLITKPQDFD 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 240 VIVTGNLFGDILSDEAAMLTGSIGMLPSASLDENgKGMYEPCHGSAPDIAGQNVANPLATILSVAMMLRYtFREEAAAKA 319
Cdd:NF040626  216 VIVTTNLFGDILSDEAAGLVGGLGLAPSANIGDK-NGLFEPVHGSAPDIAGKNIANPIAMILSASMMLDY-LGETYEANK 293

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1013840332 320 IEDAVGQVLDQG-LRTADImsEGMTKvgTAEMGEAVV 355
Cdd:NF040626  294 LENALEKVLREGkVVTPDL--GGNAK--TMEMANEIK 326
AksF_Meth NF040619
homoisocitrate dehydrogenase;
4-337 6.54e-70

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 221.94  E-value: 6.54e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332   4 QILILAGDGIGPEIVGAAEKVLNTVNEkfnlsLTWEHGLLGGAAIDAHGEPYPAVTSEQAKKADAILLGAVGGPKWDTIE 83
Cdd:NF040619    3 KICVIEGDGIGKEVIPETVRVLKELGD-----FEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPKPTELK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  84 RsiRPERG-LLKIRSELNLFANLRPAILYPQLADASSLkpeivaglDILIVRELTGGIYFGqprgiRELENGEKQGYNTD 162
Cdd:NF040619   78 N--KNYKSpILTLRKELDLYANVRPINNFGDGQDVKNI--------DFVIIRENTEGLYVG-----REYYDEENEIAIAE 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 163 -VYSESEIKRIAKVAFELAGLRG-GKVCSVDKANVLEVTE-LWKQTVTDL-QQANYSNIQLSHMYVDNAAMQLVRAPKQF 238
Cdd:NF040619  143 rIISKKGSERIIKFAFEYAKKNNrKKVSCIHKANVLRVTDgLFLEIFNEIkKKYKNFNIEADDYLVDATAMYLIKNPEMF 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 239 DVIVTGNLFGDILSDEAAMLTGSIGMLPSASLDENgKGMYEPCHGSAPDIAGQNVANPLATILSVAMMLRYtFREEAAAK 318
Cdd:NF040619  223 DVIVTTNLFGDILSDEASGLIGGLGLAPSANIGDK-KGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDY-LGMKEKGD 300

                         330
                  ....*....|....*....
gi 1013840332 319 AIEDAVGQVLDQGLRTADI 337
Cdd:NF040619  301 LIREAVKKCLENGKVTPDL 319
 
Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 1-359 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 677.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332   1 MSKQILILAGDGIGPEIVGAAEKVLNTVNEKFNLSLTWEHGLLGGAAIDAHGEPYPAVTSEQAKKADAILLGAVGGPKWD 80
Cdd:PRK00772    1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  81 TIERSIRPERGLLKIRSELNLFANLRPAILYPQLADASSLKPEIVAGLDILIVRELTGGIYFGQPRGIRElENGEKQGYN 160
Cdd:PRK00772   81 NLPPDVRPERGLLALRKELGLFANLRPAKLYPGLADASPLKPEIVAGLDILIVRELTGGIYFGEPRGREG-LGGEERAFD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 161 TDVYSESEIKRIAKVAFELAGLRGGKVCSVDKANVLEVTELWKQTVTDLQQaNYSNIQLSHMYVDNAAMQLVRAPKQFDV 240
Cdd:PRK00772  160 TMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAK-EYPDVELSHMYVDNAAMQLVRNPKQFDV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 241 IVTGNLFGDILSDEAAMLTGSIGMLPSASLDENGKGMYEPCHGSAPDIAGQNVANPLATILSVAMMLRYTFREEAAAKAI 320
Cdd:PRK00772  239 IVTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAI 318

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1013840332 321 EDAVGQVLDQGLRTADIMsEGMTKVGTAEMGEAVVAALA 359
Cdd:PRK00772  319 EAAVEKVLAQGYRTADIA-EGGGKVSTSEMGDAILAALA 356
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 2-358 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 572.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332   2 SKQILILAGDGIGPEIVGAAEKVLNTVNEKFNLSLTWEHGLLGGAAIDAHGEPYPAVTSEQAKKADAILLGAVGGPKWDt 81
Cdd:COG0473     1 TYKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWD- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  82 ieRSIRPERGLLKIRSELNLFANLRPAILYPQLAdaSSLKPEIVAGLDILIVRELTGGIYFGQPRGIRElENGEKQGYNT 161
Cdd:COG0473    80 --DGVRPESGLLALRKELDLYANLRPAKLYPGLP--SPLKPEIVEGIDLVIVRENTEGLYFGIGGRIGT-GTGEEVAIDT 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 162 DVYSESEIKRIAKVAFELAGLRGGKVCSVDKANVLEVT-ELWKQTVTDLQqANYSNIQLSHMYVDNAAMQLVRAPKQFDV 240
Cdd:COG0473   155 RVYTRKGIERIARYAFELARKRRKKVTSVDKANVLKLTsGLWREVVREVA-KEYPDVELDHMYVDAAAMQLVRNPEQFDV 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 241 IVTGNLFGDILSDEAAMLTGSIGMLPSASLDENGKGMYEPCHGSAPDIAGQNVANPLATILSVAMMLRYtFREEAAAKAI 320
Cdd:COG0473   234 IVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRH-LGEEEAADAI 312

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1013840332 321 EDAVGQVLDQGLRTADIMSegmtKVGTAEMGEAVVAAL 358
Cdd:COG0473   313 EAAVEKVLAEGVRTPDLGG----KAGTSEMGDAIIAAL 346
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 5-354 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 533.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332   5 ILILAGDGIGPEIVGAAEKVLNTVNEKFNLSLTWEHGLLGGAAIDAHGEPYPAVTSEQAKKADAILLGAVGGPKWDTIER 84
Cdd:TIGR00169   2 IAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLPR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  85 SIRPERGLLKIRSELNLFANLRPAILYPQLADASSLKPEIVAGLDILIVRELTGGIYFGQPRGIreleNGEKQGYNTDVY 164
Cdd:TIGR00169  82 DQRPEQGLLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGR----EGEGEAWDTEVY 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 165 SESEIKRIAKVAFELAGLRGGKVCSVDKANVLEVTELWKQTVTDLQQaNYSNIQLSHMYVDNAAMQLVRAPKQFDVIVTG 244
Cdd:TIGR00169 158 TVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAK-EYPDVELEHQYIDNAAMQLVKSPTQFDVVVTS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 245 NLFGDILSDEAAMLTGSIGMLPSASLDENGKGMYEPCHGSAPDIAGQNVANPLATILSVAMMLRYTFREEAAAKAIEDAV 324
Cdd:TIGR00169 237 NLFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAAV 316

                         330       340       350
                  ....*....|....*....|....*....|
gi 1013840332 325 GQVLDQGLRTADIMSEGMTKVGTAEMGEAV 354
Cdd:TIGR00169 317 KKVLAEGYRTPDLGSSATTAVGTAEMGEEL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
5-354 0e+00

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 505.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332   5 ILILAGDGIGPEIVGAAEKVLNTVNEKFNLSLTWEHGLLGGAAIDAHGEPYPAVTSEQAKKADAILLGAVGGPKWDtiER 84
Cdd:pfam00180   2 IAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWD--PA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  85 SIRPERGLLKIRSELNLFANLRPAILYPQLADASSLKPEiVAGLDILIVRELTGGIYFGQPRGIREleNGEKQGYNTDVY 164
Cdd:pfam00180  80 GVRPENGLLALRKELGLFANLRPAKVFPPLGDASPLKNE-VEGVDIVIVRELTGGIYFGIEKGIKG--SGNEVAVDTKLY 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 165 SESEIKRIAKVAFELAGLRG-GKVCSVDKANVLEVTELWKQTVTDLQQANYSNIQLSHMYVDNAAMQLVRAPKQFDVIVT 243
Cdd:pfam00180 157 SRDEIERIARVAFELARKRGrKKVTSVDKANVLKSSDLWRKIVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVT 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 244 GNLFGDILSDEAAMLTGSIGMLPSASLDENGKGMYEPCHGSAPDIAGQNVANPLATILSVAMMLRYTFREEAAAKAIEDA 323
Cdd:pfam00180 237 PNLFGDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIEAA 316

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1013840332 324 VGQVLDQGLRTADIMSEgMTKVGTAEMGEAV 354
Cdd:pfam00180 317 VLKVLESGIRTGDLAGS-ATYVSTSEFGEAV 346
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 5-358 2.02e-144

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 414.86  E-value: 2.02e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332   5 ILILAGDGIGPEIVGAAEKVLNTVNEKFNLSLTWEHGLLGGAAIDAHGEPYPAVTSEQAKKADAILLGAVGGPKWDTIER 84
Cdd:PLN02329   49 IALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGYKWDKNEK 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  85 SIRPERGLLKIRSELNLFANLRPAILYPQLADASSLKPEIVAGLDILIVRELTGGIYFGQPRGIRELENGEKQGYNTDVY 164
Cdd:PLN02329  129 HLRPEMALFYLRRDLKVFANLRPATVLPQLVDASTLKKEVAEGVDMMIVRELTGGIYFGEPRGITINENGEEVGVSTEIY 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 165 SESEIKRIAKVAFELAGLRGGKVCSVDKANVLEVTELWKQTVTDLqQANYSNIQLSHMYVDNAAMQLVRAPKQFDVIVTG 244
Cdd:PLN02329  209 AAHEIDRIARVAFETARKRRGKLCSVDKANVLDASILWRKRVTAL-ASEYPDVELSHMYVDNAAMQLIRDPKQFDTIVTN 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 245 NLFGDILSDEAAMLTGSIGMLPSASLDENGKGMYEPCHGSAPDIAGQNVANPLATILSVAMMLRYTFREEAAAKAIEDAV 324
Cdd:PLN02329  288 NIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIEDAV 367

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1013840332 325 GQVLDQGLRTADIMSEGMTKVGTAEMGEAVVAAL 358
Cdd:PLN02329  368 VDALNKGFRTGDIYSPGNKLVGCKEMGEEVLKSV 401
LEU3_arch TIGR02088
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ...
 5-354 2.25e-82

isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.


Pssm-ID: 273962  Cd Length: 322  Bit Score: 253.53  E-value: 2.25e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332   5 ILILAGDGIGPEIVGAAEKVLNTVNEKFNLSltweHGLLGGAAIDAHGEPYPAVTSEQAKKADAILLGAVGGPKwDTIER 84
Cdd:TIGR02088   1 VAVIPGDGIGPEVIEAAIRILNKLGLEIEFI----EFEAGDEALKKYGSALPEDTLEEIRKADAILFGAVTTPA-NPGYK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  85 SIrpergLLKIRSELNLFANLRPAILYPQLADASSLkpeivaGLDILIVRELTGGIYFGQPRGIRELENGEKqgyntdVY 164
Cdd:TIGR02088  76 SV-----IVTLRKELDLYANVRPAKSLPGIPDLYPN------GKDIVIVRENTEGLYAGFEFGFSDRAIAIR------VI 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 165 SESEIKRIAKVAFELAGLRGGKVCSVDKANVLEVTELWKQTVTdLQQANYSNIQLSHMYVDNAAMQLVRAPKQFDVIVTG 244
Cdd:TIGR02088 139 TREGSERIARFAFNLAKERNRKVTCVHKANVLKGTDGLFREVC-REIAKRYGVEYRDMYVDSAAMNLVKDPWRFDVIVTT 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 245 NLFGDILSDEAAMLTGSIGMLPSASLDENgKGMYEPCHGSAPDIAGQNVANPLATILSVAMMLRYTFREEAAAKaIEDAV 324
Cdd:TIGR02088 218 NMFGDILSDLASALAGSLGLAPSANIGDR-KALFEPVHGSAPDIAGKGIANPTAAILSVAMMLDYLGELEKGKL-VWEAV 295

                         330       340       350
                  ....*....|....*....|....*....|
gi 1013840332 325 GQVLDQGLRTADImsEGMTKvgTAEMGEAV 354
Cdd:TIGR02088 296 EYYIIEGKKTPDL--GGTAK--TKEVGDEI 321
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 1-358 8.06e-82

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 252.92  E-value: 8.06e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332   1 MSKQILILAGDGIGPEIVGAAEKVLNTVNEKfNLSLTWEHGLLGGAAIDAHGEPYPAVTSEQAKKADAILLGAVGGPkwd 80
Cdd:PRK03437    3 KTMKLAVIPGDGIGPEVVAEALKVLDAVAAG-GPGVETTEYDLGARRYLRTGETLPDSVLAELRQHDAILLGAIGDP--- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  81 tierSIRP---ERG-LLKIRSELNLFANLRPAILYPQLADASSLKPEIvaglDILIVRELTGGIYFGQPRGIRElengek 156
Cdd:PRK03437   79 ----SVPSgvlERGlLLKLRFALDHYVNLRPSKLYPGVTSPLAGPGDI----DFVVVREGTEGPYTGNGGALRV------ 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 157 qGYNTDVYSESEI------KRIAKVAFELAGLRGGK-VCSVDKANVLEVT-ELWKQTVTDLQqANYSNIQLSHMYVDNAA 228
Cdd:PRK03437  145 -GTPHEVATEVSVntafgvERVVRDAFERAQKRPRKhLTLVHKTNVLTFAgDLWQRTVDEVA-AEYPDVTVDYQHVDAAT 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 229 MQLVRAPKQFDVIVTGNLFGDILSDEAAMLTGSIGMLPSASLDENGKG--MYEPCHGSAPDIAGQNVANPLATILSVAMM 306
Cdd:PRK03437  223 IFMVTDPSRFDVIVTDNLFGDIITDLAAAVTGGIGLAASGNINPTGTNpsMFEPVHGSAPDIAGQGIADPTAAILSVALL 302

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1013840332 307 LRYTFREEAAAKaIEDAVgqvldqglrTADIMSEGMTKVGTAEMGEAVVAAL 358
Cdd:PRK03437  303 LDHLGEEDAAAR-IEAAV---------EADLAERGKMGRSTAEVGDRIAARL 344
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 2-358 3.23e-80

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 248.12  E-value: 3.23e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332   2 SKQILILAGDGIGPEIVGAAEKVLntvnEKFNLSLTWEHGLLGGAAIDAHGEPYPAVTSEQAKKADAILLGAVGGPKWDT 81
Cdd:PRK14025    1 MHKICVIEGDGIGKEVVPAALHVL----EATGLPFEFVYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAGETAADV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  82 IersirperglLKIRSELNLFANLRPAILYPQLadaSSLKPeivaGLDILIVRELTGGIYFGQprgirELENGEKQGYNT 161
Cdd:PRK14025   77 I----------VKLRRILDTYANVRPVKSYKGV---KCLYP----DIDYVIVRENTEGLYKGI-----EAEIADGVTVAT 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 162 DVYSESEIKRIAKVAFELAGLRG-----GKVCSVDKANVLEVTE-LWKQTVTDLQQaNYSNIQLSHMYVDNAAMQLVRAP 235
Cdd:PRK14025  135 RVITRKASERIFRFAFEMAKRRKkmgkeGKVTCAHKANVLKKTDgLFKKTFYEVAK-EYPDIKAEDYYVDAMNMYIITRP 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 236 KQFDVIVTGNLFGDILSDEAAMLTGSIGMLPSASLDENgKGMYEPCHGSAPDIAGQNVANPLATILSVAMMLRYtFREEA 315
Cdd:PRK14025  214 QTFDVVVTSNLFGDILSDGAAGLVGGLGLAPSANIGDK-YGLFEPVHGSAPDIAGKGIANPTATILTAVLMLRH-LGENE 291

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1013840332 316 AAKAIEDAVGQVLDQGLRTADIMSegmtKVGTAEMGEAVVAAL 358
Cdd:PRK14025  292 EADKVEKALEEVLALGLTTPDLGG----NLSTMEMAEEVAKRV 330
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
3-355 1.59e-79

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 246.57  E-value: 1.59e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332   3 KQILILAGDGIGPEIVGAAEKVLntvnEKFNLSLTWEHGLLGGAAIDAHGEPYPAVTSEQAKKADAILLGAVggpkwdti 82
Cdd:NF040626    2 YKITVIPGDGIGKEVMEAALYVL----DALDLNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAV-------- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  83 eRSIRPER-GLLKIRSELNLFANLRPAILYPQLadasslkPEIVAGLDILIVRELTGGIYFGQprgirELENGEKQGYNT 161
Cdd:NF040626   70 -TSTPGQKsPIITLRKELDLYANLRPIKSYEGI-------NCLFKDLDFLIVRENTEGLYSGL-----EEEYTEEKAIAE 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 162 DVYSESEIKRIAKVAFELAGLRG-GKVCSVDKANVLEVTE-LWKQTVTDLQQaNYSNIQLSHMYVDNAAMQLVRAPKQFD 239
Cdd:NF040626  137 RVITRKASERICKFAFEYAIKLGrKKVTAVHKANVLKKTDgIFKDTFYKVAK-DYPQIETEDYYVDATAMYLITKPQDFD 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 240 VIVTGNLFGDILSDEAAMLTGSIGMLPSASLDENgKGMYEPCHGSAPDIAGQNVANPLATILSVAMMLRYtFREEAAAKA 319
Cdd:NF040626  216 VIVTTNLFGDILSDEAAGLVGGLGLAPSANIGDK-NGLFEPVHGSAPDIAGKNIANPIAMILSASMMLDY-LGETYEANK 293

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1013840332 320 IEDAVGQVLDQG-LRTADImsEGMTKvgTAEMGEAVV 355
Cdd:NF040626  294 LENALEKVLREGkVVTPDL--GGNAK--TMEMANEIK 326
TTC TIGR02089
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ...
 4-358 9.17e-78

tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]


Pssm-ID: 273963  Cd Length: 352  Bit Score: 242.82  E-value: 9.17e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332   4 QILILAGDGIGPEIVGAAEKVLNTVNEKF-NLSLTWEHGLLGGAAIDAHGEPYPAVTSEQAKKADAILLGAVGGPKwdTI 82
Cdd:TIGR02089   5 RIAAIPGDGIGKEVVAAALQVLEAAAKRHgGFSLHFTEFPWSCDYYKEHGKMMPEDGLEKLKKFDAIFLGAVGWPA--LV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  83 ERSIRPERGLLKIRSELNLFANLRPAILYPQLAdaSSLKPEIVAGLDILIVRELTGGIYFGQP-RGIRELEngEKQGYNT 161
Cdd:TIGR02089  83 PDHISLWGLLLKIRREFDQYANVRPAKLLPGVT--SPLRNCGPGDFDFVVVRENSEGEYSGVGgRIHRGTD--EEVATQN 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 162 DVYSESEIKRIAKVAFELAGLRGGKVCSVDKANVLEVT-ELWKQTVTDLQqANYSNIQLSHMYVDNAAMQLVRAPKQFDV 240
Cdd:TIGR02089 159 AIFTRKGVERIMRFAFELAQKRRKHLTSATKSNGIRHSmPFWDEVFAEVA-AEYPDVEWDSYHIDALAARFVLKPETFDV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 241 IVTGNLFGDILSDEAAMLTGSIGMLPSASLDENGK--GMYEPCHGSAPDIAGQNVANPLATILSVAMMLRYTFREEAAAK 318
Cdd:TIGR02089 238 IVASNLFGDILSDLGAALMGSLGVAPSANINPEGKfpSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEHLGEKEAGAK 317

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1013840332 319 aIEDAVGQVLDQGLRTADIMSegmtKVGTAEMGEAVVAAL 358
Cdd:TIGR02089 318 -IMDAIERVTAAGILTPDVGG----KATTSEVTEAVCNAL 352
AksF_Meth NF040619
homoisocitrate dehydrogenase;
4-337 6.54e-70

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 221.94  E-value: 6.54e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332   4 QILILAGDGIGPEIVGAAEKVLNTVNEkfnlsLTWEHGLLGGAAIDAHGEPYPAVTSEQAKKADAILLGAVGGPKWDTIE 83
Cdd:NF040619    3 KICVIEGDGIGKEVIPETVRVLKELGD-----FEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPKPTELK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  84 RsiRPERG-LLKIRSELNLFANLRPAILYPQLADASSLkpeivaglDILIVRELTGGIYFGqprgiRELENGEKQGYNTD 162
Cdd:NF040619   78 N--KNYKSpILTLRKELDLYANVRPINNFGDGQDVKNI--------DFVIIRENTEGLYVG-----REYYDEENEIAIAE 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 163 -VYSESEIKRIAKVAFELAGLRG-GKVCSVDKANVLEVTE-LWKQTVTDL-QQANYSNIQLSHMYVDNAAMQLVRAPKQF 238
Cdd:NF040619  143 rIISKKGSERIIKFAFEYAKKNNrKKVSCIHKANVLRVTDgLFLEIFNEIkKKYKNFNIEADDYLVDATAMYLIKNPEMF 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 239 DVIVTGNLFGDILSDEAAMLTGSIGMLPSASLDENgKGMYEPCHGSAPDIAGQNVANPLATILSVAMMLRYtFREEAAAK 318
Cdd:NF040619  223 DVIVTTNLFGDILSDEASGLIGGLGLAPSANIGDK-KGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDY-LGMKEKGD 300

                         330
                  ....*....|....*....
gi 1013840332 319 AIEDAVGQVLDQGLRTADI 337
Cdd:NF040619  301 LIREAVKKCLENGKVTPDL 319
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 5-359 4.24e-68

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 217.67  E-value: 4.24e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332   5 ILILAGDGIGPEIVGAAEKVLNTVNE-KFNLSLTWEHGLLGGAAIDAHGEPYPAVTSEQAKKADAILLGAVGGPKWDTIE 83
Cdd:PRK08194    6 IAVIPGDGVGKEVVPAAVRVLKAVAEvHGGLKFEFTEFPWSCEYYLEHGEMMPEDGLEQLKQFDAIFLGAVGNPKLVPDH 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  84 RSIRperGLL-KIRSELNLFANLRPAILYPQLAdaSSLKPEivAGLDILIVRELTGGIYfgQPRGIReLENGEKQ-GYNT 161
Cdd:PRK08194   86 ISLW---GLLiKIRREFEQVINIRPAKQLRGIK--SPLANP--KDFDLLVVRENSEGEY--SEVGGR-IHRGEDEiAIQN 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 162 DVYSESEIKRIAKVAFELAGLRGGKVCSVDKANVLEVT-ELWKQTVTDLQQaNYSNIQLSHMYVDNAAMQLVRAPKQFDV 240
Cdd:PRK08194  156 AVFTRKGTERAMRYAFELAAKRRKHVTSATKSNGIVHSmPFWDEVFQEVGK-DYPEIETDSQHIDALAAFFVTRPEEFDV 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 241 IVTGNLFGDILSDEAAMLTGSIGMLPSASLDENGK--GMYEPCHGSAPDIAGQNVANPLATILSVAMMLRYtFREEAAAK 318
Cdd:PRK08194  235 IVASNLFGDILTDIGAAIMGSIGIAPAANINVNGKypSMFEPVHGSAPDIAGKGIANPIGQIWTAKLMLDH-FGEEELGS 313

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1013840332 319 AIEDAVGQVLDQGLRTADIMSegmtKVGTAEMGEAVVAALA 359
Cdd:PRK08194  314 HLLDVIEDVTEDGIKTPDIGG----RATTDEVTDEIISRLK 350
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 1-358 3.32e-64

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 207.26  E-value: 3.32e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332   1 MSKQILILAGDGIGPEIVGAAEKVLNtvneKFNLSLTWEHGLLGGAAIDAHGEPYPAVTSEQAKKADAILLGAVGGPKWD 80
Cdd:PRK08997    1 MKQTITVIPGDGIGPSIIDATLKILD----KLGCDFEYEFADAGLTALEKHGELLPQRTLDLIEKNKIALKGPLTTPVGE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  81 TIErSIRperglLKIRSELNLFANLRPAILYPQLADAsslkpeiVAGLDILIVRELTGGIYFGQprGIRELENGEkQGYN 160
Cdd:PRK08997   77 GFT-SIN-----VTLRKKFDLYANVRPVLSFPGTKAR-------YDNIDIITVRENTEGMYSGE--GQTVSEDGE-TAEA 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 161 TDVYSESEIKRIAKVAFELAGLRG-GKVCSVDKANVLEVTE-LWKQTVTDLQQaNYSNIQLSHMYVDNAAMQLVRAPKQF 238
Cdd:PRK08997  141 TSIITRKGAERIVRFAYELARKEGrKKVTAVHKANIMKSTSgLFLKVAREVAL-RYPDIEFEEMIVDATCMQLVMNPEQF 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 239 DVIVTGNLFGDILSDEAAMLTGSIGMLPSASLDENGkGMYEPCHGSAPDIAGQNVANPLATILSVAMMLRYTFREEAAAK 318
Cdd:PRK08997  220 DVIVTTNLFGDILSDLCAGLVGGLGMAPGANIGRDA-AIFEAVHGSAPDIAGKNLANPTSVILAAIQMLEYLGMPDKAER 298

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1013840332 319 aIEDAVGQVLDQGLR-TADIMSEGmtkvGTAEMGEAVVAAL 358
Cdd:PRK08997  299 -IRKAIVAVIEAGDRtTRDLGGTH----GTTDFTQAVIDRL 334
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
1-358 5.82e-63

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 208.21  E-value: 5.82e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332   1 MSKQILILAGDGIGPEIVGAAEKVLNTVnekfnlsltwehgllgGAAIDAH----GEP-----YPAVTSEQAkkadaill 71
Cdd:PRK09222    3 EKTPITVAYGDGIGPEIMEAVLKILEAA----------------GAPLEIEtieiGEKvykkgWTSGISPSA-------- 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  72 gavggpkWDTIERSirpeRGLLK-----------------IRSELNLFANLRPAIlypqladasSLKPEI---VAGLDIL 131
Cdd:PRK09222   59 -------WESIRRT----KVLLKapittpqgggykslnvtLRKTLGLYANVRPCV---------SYHPFVetkHPNLDVV 118

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 132 IVRE----LTGGIYFGQprgirelengekqgyNTDVY------SESEIKRIAKVAFELAGLRG-GKVCSVDKANVLEVTE 200
Cdd:PRK09222  119 IIREneedLYAGIEHRQ---------------TPDVYqclkliSRPGSEKIIRYAFEYARANGrKKVTCLTKDNIMKLTD 183

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 201 LWKQTVTDLQQANYSNIQLSHMYVDNAAMQLVRAPKQFDVIVTGNLFGDILSDEAAMLTGSIGMLPSASLDENGkGMYEP 280
Cdd:PRK09222  184 GLFHKVFDEIAKEYPDIEAEHYIVDIGAARLATNPENFDVIVTPNLYGDILSDIAAEISGSVGLAGSANIGEEY-AMFEA 262

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 281 CHGSAPDIAGQNVANPLATILSVAMMLRYTFREEAAAKaIEDAVGQVLDQGLRTADIMSEGMT--KVGTAEMGEAVVAAL 358
Cdd:PRK09222  263 VHGSAPDIAGKNIANPSGLLNAAVMMLVHIGQFDIAEL-IENAWLKTLEDGIHTADIYNEGVSkkKVGTKEFAEAVIENL 341
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 7-337 1.88e-53

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 179.50  E-value: 1.88e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332   7 ILAGDGIGPEIVGAAEKVLNTVNekfnLSLTWEhgllggaAIDAHGE-------PYPAVTSeqAKKADAILLGAVGGPKW 79
Cdd:TIGR00175   8 LIPGDGIGPEISGSVKKIFRAAN----VPIEFE-------EIDVSPQtdgkteiPDEAVES--IKRNKVALKGPLETPIG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  80 DTIERSIRperglLKIRSELNLFANLRPAILYPQLadasslkPEIVAGLDILIVRELTGGIYFGqprgireLENGEKQGY 159
Cdd:TIGR00175  75 KGGHRSLN-----VALRKELDLYANVVHCKSLPGF-------KTRHEDVDIVIIRENTEGEYSG-------LEHESVPGV 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 160 --NTDVYSESEIKRIAKVAFELAGLRGGK-VCSVDKANVLEVTE-LWKQTVTDLQqANYSNIQLSHMYVDNAAMQLVRAP 235
Cdd:TIGR00175 136 veSLKVITRDKSERIARYAFEYARKNGRKkVTAVHKANIMKLADgLFLNVCREVA-KEYPDITFESMIVDNTCMQLVSRP 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 236 KQFDVIVTGNLFGDILSDEAAMLTGSIGMLPSASLDENGKGMYEPCHGSAPDIAGQNVANPLATILSVAMMLRYTFREEA 315
Cdd:TIGR00175 215 SQFDVMVMPNLYGNILSNLGAGLVGGPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNHLGLKEH 294

                         330       340
                  ....*....|....*....|...
gi 1013840332 316 AAKaIEDAVGQVLDQG-LRTADI 337
Cdd:TIGR00175 295 ADR-IQKAVLSTIAEGkNRTKDL 316
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 5-358 2.35e-47

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 165.28  E-value: 2.35e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332   5 ILILAGDGIGPEIVGAAEKVLNTVNEK---FNLSLTWEHGLLGGAAIDAHGEPYPAVTSEQAKKadaiLLGAVGGPkwdt 81
Cdd:COG0538    21 IPFIEGDGIGPEITRAIWKVIDAAVEKaygGKRDIEWKEVDAGEKARDETGDWLPDETAEAIKE----YGVGIKGP---- 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  82 ierSIRPERGLLK-----IRSELNLFANLRPAILYPQLAdaSSLK-PEIVaglDILIVRELTGGIYfgqpRGI------- 148
Cdd:COG0538    93 ---LTTPVGGGWRslnvtIRQILDLYVCRRPVRYFKGVP--SPVKhPEKV---DIVIFRENTEDIY----AGIewkagsp 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 149 ------RELENGEKQG-YNTD--------VYSESEIKRIAKVAFELAGLRGGK-VCSVDKANVLEVTE----LW------ 202
Cdd:COG0538   161 ealkliFFLEDEMGVTvIRFPedsgigikPVSDEGTERLVRAAIQYALDNKRKsVTLVHKGNIMKFTEgafkDWgyevae 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 203 ----KQTVTDLQQANYSN------IQLSHMYVDNAAMQLVRAPKQFDVIVTGNLFGDILSDEAAMLTGSIGMLPSASLDE 272
Cdd:COG0538   241 eefgDKFITEGPWEKYKGpkpagkIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGD 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 273 NGKGMYEPCHGSAPDIAGQNVANPLATILSVAMMLRYTFREEAAAKaIEDAVGQVLDQGLRTADI--MSEGMTKVGTAEM 350
Cdd:COG0538   321 DGGAEFEATHGTAPKYAGKDSTNPGSLILSGTMMLRHRGWLEAADL-IEKAVEKTIESGKVTYDLarLMEGATELSTSEF 399


                  ....*...
gi 1013840332 351 GEAVVAAL 358
Cdd:COG0538   400 GDAIIENL 407
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 10-337 1.69e-45

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 159.66  E-value: 1.69e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  10 GDGIGPEIVGAAEKVLNTVNekfnLSLTWEHGLLGgAAIDAHGEPYpaVTSEQAkkaDAILLGAVG--GPKWDTIERSIR 87
Cdd:PLN00118   49 GDGIGPEIAESVKQVFTAAG----VPIEWEEHYVG-TTVDPRTGSF--LTWESL---ESVRRNKVGlkGPMATPIGKGHR 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  88 PERglLKIRSELNLFANLRPAILYPQLADASSlkpeivaGLDILIVRELTGGIYFGQP----RGIRElengekqgyNTDV 163
Cdd:PLN00118  119 SLN--LTLRKELGLYANVRPCYSLPGYKTRYD-------DVDLVTIRENTEGEYSGLEhqvvRGVVE---------SLKI 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 164 YSESEIKRIAKVAFELAGLRG-GKVCSVDKANVLEVTE-LWKQTVTDLQqANYSNIQLSHMYVDNAAMQLVRAPKQFDVI 241
Cdd:PLN00118  181 ITRQASLRVAEYAFHYAKTHGrKRVSAIHKANIMKKTDgLFLKCCREVA-EKYPEIVYEEVIIDNCCMMLVKNPALFDVL 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 242 VTGNLFGDILSDEAAMLTGSIGMLPSASLDENGKGMYEPCHGSAPDIAGQNVANPLATILSVAMMLRYTFREEAAAKaIE 321
Cdd:PLN00118  260 VMPNLYGDIISDLCAGLIGGLGLTPSCNIGENGLALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRHLKLNEQAEQ-IH 338

                         330
                  ....*....|....*..
gi 1013840332 322 DAVGQVLDQG-LRTADI 337
Cdd:PLN00118  339 NAILNTIAEGkYRTADL 355
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
5-356 1.40e-42

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 152.68  E-value: 1.40e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332   5 ILILAGDGIGPEIVGAAEKVLNTVNEKFNLS---LTWEHGLLGGAAIDAHGEPYPAVTSEQAKKADAILLGAVGGP---K 78
Cdd:PRK06451   26 ILYVEGDGIGPEITHAAMKVINKAVEKAYGSdreIKWVEVLAGDKAEKLTGNRFPKESEELIEKYRVLLKGPLETPigkG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  79 WDTIErsirperglLKIRSELNLFANLRPAILYPQLAdaSSLK-PEIVaglDILIVRELTGGIYFG--------QPRGIR 149
Cdd:PRK06451  106 WKSIN---------VAIRLMLDLYANIRPVKYIPGIE--SPLKnPEKI---DLIIFRENTDDLYRGieypydseEAKKIR 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 150 E-------LENGEKQGYNTDVYSESEIKRIAKVAFELA---GLRggKVCSVDKANVLEVTE----LWKQTVTDLQQANY- 214
Cdd:PRK06451  172 DflrkelgVEVEDDTGIGIKLISKFKTQRIARMAIKYAidhKRK--KVTIMHKGNVMKYTEgafrEWAYEVALKEFRDYv 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 215 ----------------SNIQLSHMYVDNAAMQLVRAPKQFDVIVTGNLFGDILSDEAAMLTGSIGMLPSASLDENGkGMY 278
Cdd:PRK06451  250 vteeevtknyngvppsGKVIINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTG-GMF 328

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1013840332 279 EPCHGSAPDIAGQNVANPLATILSVAMMLRYTFREEaAAKAIEDAVGQVLDQGLRTADIMS-EGMTKVGTAEMGEAVVA 356
Cdd:PRK06451  329 EAIHGTAPKYAGKNVANPTGIIKGGELMLRFMGWDK-AADLIDKAIMESIKQKKVTQDLARfMGVRALSTTEYTDELIS 406
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 2-358 3.07e-37

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 137.30  E-value: 3.07e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332   2 SKQILILAGDGIGPEIVGAAEKVLntvnEKFNLSLTWEhgllggaAIDAHG--EPYPAVTSEQAKKADAILLGAVGGPKW 79
Cdd:PLN00123   30 PRAVTLIPGDGIGPLVTGAVEQVM----EAMHAPVYFE-------RYEVHGdmKKVPEEVLESIRRNKVCLKGGLATPVG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  80 DTIErSIRperglLKIRSELNLFANLRPAILYPQLadasslkPEIVAGLDILIVRELTGGIYFGQPRgirELENGEKQGY 159
Cdd:PLN00123   99 GGVS-SLN-----VQLRKELDLFASLVNCFNLPGL-------PTRHENVDIVVIRENTEGEYSGLEH---EVVPGVVESL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 160 NTDVYSESEikRIAKVAFELAGLRG-GKVCSVDKANVLEVTE-LWKQTVTDLQQaNYSNIQLSHMYVDNAAMQLVRAPKQ 237
Cdd:PLN00123  163 KVITKFCSE--RIAKYAFEYAYLNNrKKVTAVHKANIMKLADgLFLESCREVAK-KYPGIKYNEIIVDNCCMQLVSKPEQ 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 238 FDVIVTGNLFGDILSDEAAMLTGSIGMLPSASLDEnGKGMYEPCHGSA----PDIAGQNVANPLATILSVAMMLRYtFRE 313
Cdd:PLN00123  240 FDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVGA-DHAVFEQGASAGnvgnEKLVEQKKANPVALLLSSAMMLRH-LQF 317

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1013840332 314 EAAAKAIEDAVGQVLDQG-LRTADIMSEGMTKvgtaEMGEAVVAAL 358
Cdd:PLN00123  318 PSFADRLETAVKRVIAEGkYRTKDLGGSSTTQ----EVVDAVIANL 359
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 10-358 4.28e-25

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 104.76  E-value: 4.28e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  10 GDGIGPEIVGAAEKVLNTVNEK-FN--LSLTWEHGLLGGAAIDAHGEPY--PAVTSEQAKKadaiLLGAVGGPKWDTIER 84
Cdd:PRK07006   27 GDGIGPDITPAMLKVVDAAVEKaYKgeRKISWMEIYAGEKATKVYGEDVwlPEETLDLIRE----YRVAIKGPLTTPVGG 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332  85 SIRPERglLKIRSELNLFANLRPaILYPQLADASSLKPEIVaglDILIVRELTGGIYFG------------------QPR 146
Cdd:PRK07006  103 GIRSLN--VALRQELDLYVCLRP-VRYFKGVPSPVKRPEDT---DMVIFRENSEDIYAGiewkagsaeakkvikflqEEM 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 147 GIRELENGEKQGYNTDVYSESEIKRIAKVAFELAGLRGGK-VCSVDKANVLEVTE-LWKQTVTDLQQANYS--------- 215
Cdd:PRK07006  177 GVKKIRFPETSGIGIKPVSEEGTERLVRAAIEYAIDNDRKsVTLVHKGNIMKFTEgAFKDWGYQLAEEEFGdelidggpw 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 216 ----------NIQLSHMYVDNAAMQLVRAPKQFDVIVTGNLFGDILSDEAAMLTGSIGMLPSASLDeNGKGMYEPCHGSA 285
Cdd:PRK07006  257 dkiknpetgkEIIVKDSIADAFLQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANIN-DGHAIFEATHGTA 335

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1013840332 286 PDIAGQNVANPLATILSVAMMLRYTFREEAAAKaIEDAVGQVLDQGLRTADI--MSEGMTKVGTAEMGEAVVAAL 358
Cdd:PRK07006  336 PKYAGLDKVNPGSVILSAEMMLRHMGWTEAADL-IIKSMEKTIASKTVTYDFarLMEGATEVKCSEFGDALIKNM 409
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
225-324 7.56e-14

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 72.44  E-value: 7.56e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1013840332 225 DNAAMQLVRAPKQFDVIVTGNLFGDILSDEAAMLTGSIGMLPSASLDENGkGMYEPCHGSAPDIAGQNVANPLATILSVA 304
Cdd:PRK07362  340 DSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNA-AIFEATHGTAPKHAGLDRINPGSVILSGV 418

                          90       100
                  ....*....|....*....|...
gi 1013840332 305 MMLRYTFREEAA---AKAIEDAV 324
Cdd:PRK07362  419 MMLEYLGWQEAAdliTKGLSAAI 441
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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