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Conserved domains on  [gi|1023247986|gb|KZT43740|]
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hypothetical protein SISSUDRAFT_1029513 [Sistotremastrum suecicum HHB10207 ss-3]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_ScUFO1-like cd22145
F-box domain found in Saccharomyces cerevisiae ubiquitin ligase complex F-box protein UFO1 ...
 4-44 6.16e-15

F-box domain found in Saccharomyces cerevisiae ubiquitin ligase complex F-box protein UFO1 (ScUFO1) and similar proteins; ScUFO1 is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It probably recognizes and binds to phosphorylated target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438916  Cd Length: 41  Bit Score: 67.81  E-value: 6.16e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1023247986   4 IRFNNLPSDILFELFGYLELQDIFAVEQVSRHLRTLIRSSR 44
Cdd:cd22145     1 LSLASLPTDVLLNIFLYLSLRDLLAVRQVSRHFRALIHLRE 41
 
Name Accession Description Interval E-value
F-box_ScUFO1-like cd22145
F-box domain found in Saccharomyces cerevisiae ubiquitin ligase complex F-box protein UFO1 ...
 4-44 6.16e-15

F-box domain found in Saccharomyces cerevisiae ubiquitin ligase complex F-box protein UFO1 (ScUFO1) and similar proteins; ScUFO1 is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It probably recognizes and binds to phosphorylated target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438916  Cd Length: 41  Bit Score: 67.81  E-value: 6.16e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1023247986   4 IRFNNLPSDILFELFGYLELQDIFAVEQVSRHLRTLIRSSR 44
Cdd:cd22145     1 LSLASLPTDVLLNIFLYLSLRDLLAVRQVSRHFRALIHLRE 41
FBOX smart00256
A Receptor for Ubiquitination Targets;
9-44 1.30e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 44.35  E-value: 1.30e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1023247986    9 LPSDILFELFGYLELQDIFAVEQVSRHLRTLIRSSR 44
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHD 36
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 6-47 1.20e-05

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 41.70  E-value: 1.20e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1023247986   6 FNNLPSDILFELFGYLELQDIFAVEQVSRHLRTLIRSSRaIW 47
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDS-LW 41
 
Name Accession Description Interval E-value
F-box_ScUFO1-like cd22145
F-box domain found in Saccharomyces cerevisiae ubiquitin ligase complex F-box protein UFO1 ...
 4-44 6.16e-15

F-box domain found in Saccharomyces cerevisiae ubiquitin ligase complex F-box protein UFO1 (ScUFO1) and similar proteins; ScUFO1 is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It probably recognizes and binds to phosphorylated target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438916  Cd Length: 41  Bit Score: 67.81  E-value: 6.16e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1023247986   4 IRFNNLPSDILFELFGYLELQDIFAVEQVSRHLRTLIRSSR 44
Cdd:cd22145     1 LSLASLPTDVLLNIFLYLSLRDLLAVRQVSRHFRALIHLRE 41
FBOX smart00256
A Receptor for Ubiquitination Targets;
9-44 1.30e-06

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 44.35  E-value: 1.30e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1023247986    9 LPSDILFELFGYLELQDIFAVEQVSRHLRTLIRSSR 44
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHD 36
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 6-47 1.20e-05

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 41.70  E-value: 1.20e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1023247986   6 FNNLPSDILFELFGYLELQDIFAVEQVSRHLRTLIRSSRaIW 47
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDS-LW 41
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 6-44 4.08e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 40.22  E-value: 4.08e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1023247986   6 FNNLPSDILFELFGYLELQDIFAVEQVSRHLRTLIRSSR 44
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLK 39
F-box_FBXO1 cd22082
F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called ...
 8-51 9.74e-05

F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called FBX1, or cyclin-F, is a substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438854  Cd Length: 52  Bit Score: 39.54  E-value: 9.74e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1023247986   8 NLPSDILFELFGYLELQDIFAVEQVSRHLRTLIRSSRAIWLSVT 51
Cdd:cd22082     4 SLPEEVLLHILKGLPIKDLLNMRAVHSRFKDLIDSNPSLWANAS 47
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 7-41 1.15e-04

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 38.96  E-value: 1.15e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1023247986   7 NNLPSDILFELFGYLELQDIFAVEQVSRHLRTLIR 41
Cdd:cd09917     1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box_FBXW4 cd20090
F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, ...
 6-48 3.22e-04

F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, also called dactylin, or F-box and WD-40 domain-containing protein 4, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is likely to be involved in key signaling pathways crucial for normal limb development. It may participate in Wnt signaling and act as a novel tumor suppressor that regulates important cellular processes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438853  Cd Length: 47  Bit Score: 37.96  E-value: 3.22e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1023247986   6 FNNLPSDILFELFGYLELQDIFAVEQVSRHLRTLIrSSRAIWL 48
Cdd:cd20090     2 LLDLPDDLLFLIFSYLDPASLGRLSQVCRRLYRLI-SRDAVWR 43
F-box_FBXO3 cd22084
F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called ...
 6-39 4.62e-03

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438856  Cd Length: 49  Bit Score: 34.54  E-value: 4.62e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1023247986   6 FNNLPSDILFELFGYLELQDIFAVEQVSRHLRTL 39
Cdd:cd22084     1 LDDLPSDPLLNILSFLDYRDLISCSQVCRRLNQL 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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