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Conserved domains on  [gi|1024600877|gb|KZY90364|]
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dTDP-6-deoxy-3,4-keto-hexulose isomerase [Oleiphilus sp. HI0071]

Protein Classification

sugar 3,4-ketoisomerase( domain architecture ID 14448982)

sugar 3,4-ketoisomerase, such as Aneurinibacillus thermoaerophilus TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (FdtA), which mediates the isomerization of dTDP-6-deoxy-D-xylohex-4-ulose into dTDP-6-deoxy-D-xylohex-3-ulose in the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose, a glycan chain of the S-layer

CATH:  2.60.120.10
EC:  5.3.2.-
PubMed:  26125548|19478949|14697267|9573603
SCOP:  3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cupin_QdtA-like cd20292
sugar 3,4-ketoisomerase QdtA and related proteins, cupin domain; This family includes cupin ...
 15-128 6.79e-55

sugar 3,4-ketoisomerase QdtA and related proteins, cupin domain; This family includes cupin domains of several bacterial proteins homologous to sugar 3,4-ketoisomerases. Thermoanaerobacterium thermosaccharolyticum QdtA catalyzes a key step in the biosynthesis of these sugars, the conversion of thymidine diphosphate (dTDP)-4-keto-6-deoxyglucose to dTDP-3-keto-6-deoxyglucose. In Aneurinibacillus thermoaerophilus, TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (also known as FdtA) is involved in the biosynthesis of dTDP-Fucp3NAc (3-acetamido-3,6-dideoxy-alpha-d-galactose), which is part of the repeating units of the glycan chain in the S-layer. Shewanella denitrificans bifunctional ketoisomerase/N-acetyltransferase (also known as FdtD) is involved in the third and fifth steps in the production of 3-acetamido-3,6-dideoxy-alpha-d-galactose or Fuc3NAc; the C-terminal cupin domain harbors the active site responsible for the isomerization reaction. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


:

Pssm-ID: 380426  Cd Length: 117  Bit Score: 167.65  E-value: 6.79e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024600877  15 FSSLGDSRGELIALEQFKEIPFEIKRIYYIFQTAENVKRGFHAHQSLKQVAIALSGSCVFDVETESGSSSHLLDSPSKGL 94
Cdd:cd20292     4 LPTITDERGSLTVIEFEKDIPFEIKRVFYIYGVPGGAVRGGHAHKKLEQLLICLSGSCEVILDDGKEKEEFVLDSPNKGL 83

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1024600877  95 YMGGLVWREMRDFSHDCVLLVIASECYDEADYIR 128
Cdd:cd20292    84 YIPPGVWHEMYDFSPDAVLLVLASEPYDESDYIR 117
 
Name Accession Description Interval E-value
cupin_QdtA-like cd20292
sugar 3,4-ketoisomerase QdtA and related proteins, cupin domain; This family includes cupin ...
 15-128 6.79e-55

sugar 3,4-ketoisomerase QdtA and related proteins, cupin domain; This family includes cupin domains of several bacterial proteins homologous to sugar 3,4-ketoisomerases. Thermoanaerobacterium thermosaccharolyticum QdtA catalyzes a key step in the biosynthesis of these sugars, the conversion of thymidine diphosphate (dTDP)-4-keto-6-deoxyglucose to dTDP-3-keto-6-deoxyglucose. In Aneurinibacillus thermoaerophilus, TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (also known as FdtA) is involved in the biosynthesis of dTDP-Fucp3NAc (3-acetamido-3,6-dideoxy-alpha-d-galactose), which is part of the repeating units of the glycan chain in the S-layer. Shewanella denitrificans bifunctional ketoisomerase/N-acetyltransferase (also known as FdtD) is involved in the third and fifth steps in the production of 3-acetamido-3,6-dideoxy-alpha-d-galactose or Fuc3NAc; the C-terminal cupin domain harbors the active site responsible for the isomerization reaction. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380426  Cd Length: 117  Bit Score: 167.65  E-value: 6.79e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024600877  15 FSSLGDSRGELIALEQFKEIPFEIKRIYYIFQTAENVKRGFHAHQSLKQVAIALSGSCVFDVETESGSSSHLLDSPSKGL 94
Cdd:cd20292     4 LPTITDERGSLTVIEFEKDIPFEIKRVFYIYGVPGGAVRGGHAHKKLEQLLICLSGSCEVILDDGKEKEEFVLDSPNKGL 83

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1024600877  95 YMGGLVWREMRDFSHDCVLLVIASECYDEADYIR 128
Cdd:cd20292    84 YIPPGVWHEMYDFSPDAVLLVLASEPYDESDYIR 117
FdtA pfam05523
WxcM-like, C-terminal; This family includes FdtA from Aneurinibacillus thermoaerophilus, which ...
 9-135 5.79e-48

WxcM-like, C-terminal; This family includes FdtA from Aneurinibacillus thermoaerophilus, which has been characterized as a dtdp-6-deoxy-3,4-keto-hexulose isomerase. It also includes WxcM from Xanthomonas campestris (pv. campestris).


Pssm-ID: 428507  Cd Length: 129  Bit Score: 150.82  E-value: 5.79e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024600877   9 DVRELLFSSLGDSRGELIALEQFKEIPFEIKRIYYIFQTAENVKRGFHAHQSLKQVAIALSGSCvfDVETESGSSSH--L 86
Cdd:pfam05523   1 DVKLIELPKIKDPRGNLSVIEFGKHIPFEIKRVYYVYDVPSGEVRGEHAHKKLHQFLICLSGSC--DVILDDGKNKKefL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1024600877  87 LDSPSKGLYMGGLVWREMRDFSHDCVLLVIASECYDEADYIRSYDAFKH 135
Cdd:pfam05523  79 LNRPSKGLYIPPMIWREQYNFSKGAVLLVLASDYYDEDDYIRDYDEFLA 127
 
Name Accession Description Interval E-value
cupin_QdtA-like cd20292
sugar 3,4-ketoisomerase QdtA and related proteins, cupin domain; This family includes cupin ...
 15-128 6.79e-55

sugar 3,4-ketoisomerase QdtA and related proteins, cupin domain; This family includes cupin domains of several bacterial proteins homologous to sugar 3,4-ketoisomerases. Thermoanaerobacterium thermosaccharolyticum QdtA catalyzes a key step in the biosynthesis of these sugars, the conversion of thymidine diphosphate (dTDP)-4-keto-6-deoxyglucose to dTDP-3-keto-6-deoxyglucose. In Aneurinibacillus thermoaerophilus, TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase (also known as FdtA) is involved in the biosynthesis of dTDP-Fucp3NAc (3-acetamido-3,6-dideoxy-alpha-d-galactose), which is part of the repeating units of the glycan chain in the S-layer. Shewanella denitrificans bifunctional ketoisomerase/N-acetyltransferase (also known as FdtD) is involved in the third and fifth steps in the production of 3-acetamido-3,6-dideoxy-alpha-d-galactose or Fuc3NAc; the C-terminal cupin domain harbors the active site responsible for the isomerization reaction. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380426  Cd Length: 117  Bit Score: 167.65  E-value: 6.79e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024600877  15 FSSLGDSRGELIALEQFKEIPFEIKRIYYIFQTAENVKRGFHAHQSLKQVAIALSGSCVFDVETESGSSSHLLDSPSKGL 94
Cdd:cd20292     4 LPTITDERGSLTVIEFEKDIPFEIKRVFYIYGVPGGAVRGGHAHKKLEQLLICLSGSCEVILDDGKEKEEFVLDSPNKGL 83

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1024600877  95 YMGGLVWREMRDFSHDCVLLVIASECYDEADYIR 128
Cdd:cd20292    84 YIPPGVWHEMYDFSPDAVLLVLASEPYDESDYIR 117
FdtA pfam05523
WxcM-like, C-terminal; This family includes FdtA from Aneurinibacillus thermoaerophilus, which ...
 9-135 5.79e-48

WxcM-like, C-terminal; This family includes FdtA from Aneurinibacillus thermoaerophilus, which has been characterized as a dtdp-6-deoxy-3,4-keto-hexulose isomerase. It also includes WxcM from Xanthomonas campestris (pv. campestris).


Pssm-ID: 428507  Cd Length: 129  Bit Score: 150.82  E-value: 5.79e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1024600877   9 DVRELLFSSLGDSRGELIALEQFKEIPFEIKRIYYIFQTAENVKRGFHAHQSLKQVAIALSGSCvfDVETESGSSSH--L 86
Cdd:pfam05523   1 DVKLIELPKIKDPRGNLSVIEFGKHIPFEIKRVYYVYDVPSGEVRGEHAHKKLHQFLICLSGSC--DVILDDGKNKKefL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1024600877  87 LDSPSKGLYMGGLVWREMRDFSHDCVLLVIASECYDEADYIRSYDAFKH 135
Cdd:pfam05523  79 LNRPSKGLYIPPMIWREQYNFSKGAVLLVLASDYYDEDDYIRDYDEFLA 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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