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Conserved domains on  [gi|2245401946|sp|M0R3Q7|]
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RecName: Full=Patched domain-containing protein 3

Protein Classification

patched/dispatched family protein( domain architecture ID 1904021)

patched/dispatched family protein may be involved in hedgehog (Hh) signaling, similar to Drosophila melanogaster proteins patched and dispatched, that acts as a receptor for Hh and a regulator of Hh trafficking, respectively

Gene Ontology:  GO:0007165|GO:0016020
PubMed:  36932157|21778405

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Patched super family cl44384
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 125-905 1.28e-154

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


The actual alignment was detected with superfamily member pfam02460:

Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 474.15  E-value: 1.28e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 125 YTPIGSPAKAERrfvqSHFSTN---DSYRFSASRTSSETNFASILVVSHRDSLLEPEAFAEVSRLDRAVQALKVVQENGT 201
Cdd:pfam02460  10 RTPDDARSFTER----GVRSEYeplVENKFFPGDSYPEARFLIITAKGRNSNILDISYLNDIYQLNDYISTNVEIQVDGI 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 202 QILYPEVCAKYSVGCVPPNPLLFSW-QQNSSLNLSELTFPIHSVADHLIHLAGFFGGnvlgyATTGNRQRLVESRAMRLL 280
Cdd:pfam02460  86 IISFKDLCSRYCDLNCPVNKHYNGMlLSRRHNTRIDITYPIMPVLGTPIYLGPHFGG-----VDFEPPGNISYAKAIVLW 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 281 YYLKTEDPEDRERSQAWLTHFLDHFNDMKSDlalEDIEVVYFTSLSRQLEFEATSKTVIPLFHLAYILIILFAVVSCSRL 360
Cdd:pfam02460 161 YFLKFDEEEVEEDSKEWEDELSQLLHNKYAS---EHIQFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVSVTL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 361 -----DCIRNKMWVAVFGVFSVAMSVVSGFGLMLHIGVPFVIIVANSPFLILGVGVDDMFIMISAWQKTSLTESVSERLS 435
Cdd:pfam02460 238 ssytiDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVLAIGVDDMFLMVAAWQRTTATLSVKKRMG 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 436 NSYSKVAVSITITTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAIMALDGKREV----VWSRWLEKPD 511
Cdd:pfam02460 318 EALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAICAKPEAegrhCLFVWATSSP 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 512 QKYSSFkkfccvpfGSFPDEHGDDNHPMNLFFRDYFGPFLTTSKAKFIVVLIYIFYIISSIYGCFQVQEGLDLRNLASDD 591
Cdd:pfam02460 398 QRIDSE--------GSEPDKSHNIEQLKSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLED 469

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 592 SYITPYFNVEEDYFSDYGPRVMVIVTETVNYWDKDVRQKLDKCMTQFEQNEY-VDKNLTEFWLEAYMQY---MNNTGNNP 667
Cdd:pfam02460 470 SPLVEYLSLREKHFWPEGLQIQVAVNNPPNLTIPESRDRMNEMVDEFENTPYsLGPNSTLFWLREYENFlstLNMEEEED 549

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 668 NDKNTFMNNIAGFLN--FFPVFTYDINVSSSN-EITSSRGFIQTIDVSSSSNKKRMLLKLRGIA-ENCEVPLMVYNQAFI 743
Cdd:pfam02460 550 EEKEWSYGNLPSFLKapGNSHWAGDLVWDDNTtMVTKFRFTLAGKGLSTWNDRTRALQEWRSIAdQYPEFNVTVFDEDAP 629

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 744 YFDQYAAIIENTVRNVMIASTAMFIVSLLLIPHPVCSLWVTFAIASVIVGVTGFMAFWNVNLDSISMINLVICIGFSFDF 823
Cdd:pfam02460 630 FADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDF 709

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 824 SAHISYAFVSSNEPSVNKKSIEALYLLGYPVLQSAISTIIGVCVLAAAKAYIFRTFFKIMFLVMFFGAAHGLIFIPVFLT 903
Cdd:pfam02460 710 SAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTILGVLVLLFVPSYMVVVFFKTVFLVVAIGLLHGLFILPIILS 789


                  ..
gi 2245401946 904 FF 905
Cdd:pfam02460 790 LF 791
 
Name Accession Description Interval E-value
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 125-905 1.28e-154

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 474.15  E-value: 1.28e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 125 YTPIGSPAKAERrfvqSHFSTN---DSYRFSASRTSSETNFASILVVSHRDSLLEPEAFAEVSRLDRAVQALKVVQENGT 201
Cdd:pfam02460  10 RTPDDARSFTER----GVRSEYeplVENKFFPGDSYPEARFLIITAKGRNSNILDISYLNDIYQLNDYISTNVEIQVDGI 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 202 QILYPEVCAKYSVGCVPPNPLLFSW-QQNSSLNLSELTFPIHSVADHLIHLAGFFGGnvlgyATTGNRQRLVESRAMRLL 280
Cdd:pfam02460  86 IISFKDLCSRYCDLNCPVNKHYNGMlLSRRHNTRIDITYPIMPVLGTPIYLGPHFGG-----VDFEPPGNISYAKAIVLW 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 281 YYLKTEDPEDRERSQAWLTHFLDHFNDMKSDlalEDIEVVYFTSLSRQLEFEATSKTVIPLFHLAYILIILFAVVSCSRL 360
Cdd:pfam02460 161 YFLKFDEEEVEEDSKEWEDELSQLLHNKYAS---EHIQFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVSVTL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 361 -----DCIRNKMWVAVFGVFSVAMSVVSGFGLMLHIGVPFVIIVANSPFLILGVGVDDMFIMISAWQKTSLTESVSERLS 435
Cdd:pfam02460 238 ssytiDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVLAIGVDDMFLMVAAWQRTTATLSVKKRMG 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 436 NSYSKVAVSITITTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAIMALDGKREV----VWSRWLEKPD 511
Cdd:pfam02460 318 EALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAICAKPEAegrhCLFVWATSSP 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 512 QKYSSFkkfccvpfGSFPDEHGDDNHPMNLFFRDYFGPFLTTSKAKFIVVLIYIFYIISSIYGCFQVQEGLDLRNLASDD 591
Cdd:pfam02460 398 QRIDSE--------GSEPDKSHNIEQLKSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLED 469

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 592 SYITPYFNVEEDYFSDYGPRVMVIVTETVNYWDKDVRQKLDKCMTQFEQNEY-VDKNLTEFWLEAYMQY---MNNTGNNP 667
Cdd:pfam02460 470 SPLVEYLSLREKHFWPEGLQIQVAVNNPPNLTIPESRDRMNEMVDEFENTPYsLGPNSTLFWLREYENFlstLNMEEEED 549

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 668 NDKNTFMNNIAGFLN--FFPVFTYDINVSSSN-EITSSRGFIQTIDVSSSSNKKRMLLKLRGIA-ENCEVPLMVYNQAFI 743
Cdd:pfam02460 550 EEKEWSYGNLPSFLKapGNSHWAGDLVWDDNTtMVTKFRFTLAGKGLSTWNDRTRALQEWRSIAdQYPEFNVTVFDEDAP 629

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 744 YFDQYAAIIENTVRNVMIASTAMFIVSLLLIPHPVCSLWVTFAIASVIVGVTGFMAFWNVNLDSISMINLVICIGFSFDF 823
Cdd:pfam02460 630 FADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDF 709

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 824 SAHISYAFVSSNEPSVNKKSIEALYLLGYPVLQSAISTIIGVCVLAAAKAYIFRTFFKIMFLVMFFGAAHGLIFIPVFLT 903
Cdd:pfam02460 710 SAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTILGVLVLLFVPSYMVVVFFKTVFLVVAIGLLHGLFILPIILS 789


                  ..
gi 2245401946 904 FF 905
Cdd:pfam02460 790 LF 791
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 78-905 2.04e-63

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 233.26  E-value: 2.04e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946   78 LSSCFLRLGALVGANPWLFLLGPVLLTASLGTGLIFLPKEKENLEEQYTPiGSPAKAERRFVQSHFSTndSYR-----FS 152
Cdd:TIGR00917  309 LARFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAP-GSRAALEKQYFDTHFGP--FYRieqliIA 385

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  153 ASRTSSETNFASILvvshrdsllEPEAFAEVSRLDRAVQALKVVQENGTQILYPEVCAKYSVGCVPPNPLLFSWQQNSSl 232
Cdd:TIGR00917  386 TVQTSSHEKAPEIL---------TDDNLKLLFDIQKKVSQLFANYEGELITLDSPCFKPNHPYNCFIYSTCKKLQNMYS- 455

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  233 NLSELTFPIHSVADHLIHL----------AGFFGGNVLGYATTG--NRQRLVESRAMRLLYYLKT--EDPEDRERSQAWL 298
Cdd:TIGR00917  456 KLKPENYDDYGGVDYVKYCfehftspescLSAFGGPVDPTTVLGgfSGNNFSEASAFVVTFPVNNfvNKTNKTEKAVAWE 535

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  299 THFLDHFNDMKSDLALEDIEVVYFTSLSRQLEFEATSKT----VIPLFHLAYILIILFAVVSCSRLdCIRNKMWVAVFGV 374
Cdd:TIGR00917  536 KAFIQLAKDELLPMVQATISFSAERSIEDELKRESTADVitiaISYLVMFAYISLTLGDSPRLKSL-YVTSKVLLGLSGI 614

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  375 FSVAMSVVSGFGLMLHIGVPFVIIVANS-PFLILGVGVDDMFIMISAWQ-----------KTSLTESVSERLSNSYSKVA 442
Cdd:TIGR00917  615 LIVMLSVLGSVGVFSAVGLKSTLIIMEViPFLVLAVGVDNIFILVFFYFyleyfyrqvgvDNEQELTLERRLSRALMEVG 694

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  443 VSITITTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAIMALDGKRevvwsrwlekpdQKYSSFKKFCC 522
Cdd:TIGR00917  695 PSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKR------------TEDKRVDCFPC 762

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  523 VPF--GSFPDEHGDDNHPMNL---FFRDYFGPFLTTSKAKFIVVLIYIFYIISSIYGCFQVQEGLDLRNLASDDSYITPY 597
Cdd:TIGR00917  763 IKTskSSISAEKGSGQRKAGLltrYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIY 842

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  598 FNVEEDYFsDYGPRVMVIVTETVNYWDKDVRQKL--------DKCMTQFEQNEYVDKNLTEfWLEAYMQYM--------- 660
Cdd:TIGR00917  843 FASLTPLL-EVGPPFYIVIKGDYNYTDFESQNKLctmggcdkDSIVNVFNNLSYIAKPASS-WLDDYLVWLspqascccr 920

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  661 -NNTG---NNPNDK----NTFMNNIAG------FLNFFPVFTYDIN-----------VSSSNEITSSRGFIQ-------- 707
Cdd:TIGR00917  921 kFTNGtfcNGPDPQcfrcADLSSDAQGrpsttqFKEKLPWFLNALPsadcakgghaaYSSAVDLQGYATIIQassfrtyh 1000

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  708 -----TIDVSSSSNKKRMLLKlrGIAENCEVPLMVYNQAFIYFDQYAAIIENTVRNVMIASTAMFIVSLLLIPhpvCSLW 782
Cdd:TIGR00917 1001 tplntQVDFINAMRAAQEFAA--KVSRSSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQ---LNAL 1075

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  783 VTF----AIASVIVGVTGFMAFWNVNLDSISMINLVICIGFSFDFSAHISYAFVSSNEPSVNKKSIEALYLLGYPVLQS- 857
Cdd:TIGR00917 1076 SVVnlimSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFSGi 1155

                          890       900       910       920
                   ....*....|....*....|....*....|....*....|....*....
gi 2245401946  858 AISTIIGVCVLAAAKAYIFRTFFKIMFLVM-FFGAAHGLIFIPVFLTFF 905
Cdd:TIGR00917 1156 TLTKLVGVVVLGFSRSEIFVVYYFRMYLALvLLGFLHGLVFLPVLLSVL 1204
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
82-905 1.47e-26

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 116.50  E-value: 1.47e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  82 FLRLGALVGANPWLFLLGPVLLTASLGTGLIFLpkEKENLEEQYTPIGSPAKAERRFVQSHFSTNDSyrfsasrtssetn 161
Cdd:COG1033     4 MERLARFILRHRKLVLLLFLLLTLLLAYGAPKL--EVDTDFESLLPEDDPSVQAYDEFEEEFGGDDT------------- 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 162 faSILVVSHRDSLLEPEAFAEVSRLDRAVQALKVVQE--NGTQILYPEVcakysvgcvPPNPLLFSWQQNSSLNLSELTF 239
Cdd:COG1033    69 --VVVAVEGKDDIFTPETLEALRELTEELEEIPGVDSvtSLTNVRATEG---------TEDGLTVEPLIPDELPASPEEL 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 240 PihSVADHLIHLAGFFGGNVLGYATTgnrqrlvesrAMRLLYYLKTEDPEDRERSQAwlthfLDHFNDMKSDLALEDIEV 319
Cdd:COG1033   138 A--ELREKVLSSPLYVGRLVSPDGKA----------TLIVVTLDPDPLSSDLDRKEV-----VAEIRAIIAKYEDPGVEV 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 320 VYF-TSLSRQLEFEATSKTVIPLFHLAYILIILFAVVSCSRLdcirnkmWVAVFGVFSVAMSVVSGFGLMLHIGVPFVII 398
Cdd:COG1033   201 YLTgFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSL-------RGVLLPLLVVLLAVIWTLGLMGLLGIPLSPL 273

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 399 VANSPFLILGVGVDDMFIMISAWQK-TSLTESVSERLSNSYSKVAVSITITTITNVLAFYTGITSSFRSVQYFCIYTGTT 477
Cdd:COG1033   274 TILVPPLLLAIGIDYGIHLLNRYREeRRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIG 353

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 478 LLFCYFYSITCFGAIMALdgkrevvwsrwLEKPDQKYSSFKKfccvpfgsfpdeHGDDNHPMNLFFRdyfgpfLTTSKAK 557
Cdd:COG1033   354 VLLAFLTSLTLLPALLSL-----------LPRPKPKTRRLKK------------PPELGRLLAKLAR------FVLRRPK 404

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 558 FIVVLIYIFYIISSIyGCFQVQ-EGLDLRNLASDDSYITPYFNVEEDYFSDYGPRVMVIVTETVNYWDKDVRQKLDKCMT 636
Cdd:COG1033   405 VILVVALVLAVVSLY-GISRLKvEYDFEDYLPEDSPIRQDLDFIEENFGGSDPLEVVVDTGEPDGLKDPEVLKEIDRLQD 483

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 637 QFEQNEYVDKNLTefwLEAYMQYMNNTGNNPNDKNTFMNNIAGFLNFFPVFTYDINVSSSNEITS---SRGFIQ-TIDVS 712
Cdd:COG1033   484 YLESLPEVGKVLS---LADLVKELNQALNEGDPKYYALPESRELLAQLLLLLSSPPGDDLSRFVDedySAARVTvRLKDL 560

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 713 SSSNKKRMLLKLR-GIAENCEVPLMVYN---QAFIYFDQYAAIIENTVRNVMIASTAMFIVSLLL---IPHPVCSLwvtF 785
Cdd:COG1033   561 DSEEIKALVEEVRaFLAENFPPDGVEVTltgSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAfrsLRLGLISL---I 637

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 786 AIASVIVGVTGFMAFWNVNLDSISMINLVICIGFSFDFSAHISYAFVSsnEPSVNKKSIEALYLL----GYPVLQSAIST 861
Cdd:COG1033   638 PNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYRE--ERRKGGDLEEAIRRAlrttGKAILFTSLTL 715

                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....
gi 2245401946 862 IIGVCVLAAAKAYIFRTFFKIMFLVMFFGAAHGLIFIPVFLTFF 905
Cdd:COG1033   716 AAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLL 759
 
Name Accession Description Interval E-value
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 125-905 1.28e-154

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 474.15  E-value: 1.28e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 125 YTPIGSPAKAERrfvqSHFSTN---DSYRFSASRTSSETNFASILVVSHRDSLLEPEAFAEVSRLDRAVQALKVVQENGT 201
Cdd:pfam02460  10 RTPDDARSFTER----GVRSEYeplVENKFFPGDSYPEARFLIITAKGRNSNILDISYLNDIYQLNDYISTNVEIQVDGI 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 202 QILYPEVCAKYSVGCVPPNPLLFSW-QQNSSLNLSELTFPIHSVADHLIHLAGFFGGnvlgyATTGNRQRLVESRAMRLL 280
Cdd:pfam02460  86 IISFKDLCSRYCDLNCPVNKHYNGMlLSRRHNTRIDITYPIMPVLGTPIYLGPHFGG-----VDFEPPGNISYAKAIVLW 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 281 YYLKTEDPEDRERSQAWLTHFLDHFNDMKSDlalEDIEVVYFTSLSRQLEFEATSKTVIPLFHLAYILIILFAVVSCSRL 360
Cdd:pfam02460 161 YFLKFDEEEVEEDSKEWEDELSQLLHNKYAS---EHIQFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVSVTL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 361 -----DCIRNKMWVAVFGVFSVAMSVVSGFGLMLHIGVPFVIIVANSPFLILGVGVDDMFIMISAWQKTSLTESVSERLS 435
Cdd:pfam02460 238 ssytiDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVLAIGVDDMFLMVAAWQRTTATLSVKKRMG 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 436 NSYSKVAVSITITTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAIMALDGKREV----VWSRWLEKPD 511
Cdd:pfam02460 318 EALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAICAKPEAegrhCLFVWATSSP 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 512 QKYSSFkkfccvpfGSFPDEHGDDNHPMNLFFRDYFGPFLTTSKAKFIVVLIYIFYIISSIYGCFQVQEGLDLRNLASDD 591
Cdd:pfam02460 398 QRIDSE--------GSEPDKSHNIEQLKSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLED 469

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 592 SYITPYFNVEEDYFSDYGPRVMVIVTETVNYWDKDVRQKLDKCMTQFEQNEY-VDKNLTEFWLEAYMQY---MNNTGNNP 667
Cdd:pfam02460 470 SPLVEYLSLREKHFWPEGLQIQVAVNNPPNLTIPESRDRMNEMVDEFENTPYsLGPNSTLFWLREYENFlstLNMEEEED 549

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 668 NDKNTFMNNIAGFLN--FFPVFTYDINVSSSN-EITSSRGFIQTIDVSSSSNKKRMLLKLRGIA-ENCEVPLMVYNQAFI 743
Cdd:pfam02460 550 EEKEWSYGNLPSFLKapGNSHWAGDLVWDDNTtMVTKFRFTLAGKGLSTWNDRTRALQEWRSIAdQYPEFNVTVFDEDAP 629

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 744 YFDQYAAIIENTVRNVMIASTAMFIVSLLLIPHPVCSLWVTFAIASVIVGVTGFMAFWNVNLDSISMINLVICIGFSFDF 823
Cdd:pfam02460 630 FADQYLTILPSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDF 709

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 824 SAHISYAFVSSNEPSVNKKSIEALYLLGYPVLQSAISTIIGVCVLAAAKAYIFRTFFKIMFLVMFFGAAHGLIFIPVFLT 903
Cdd:pfam02460 710 SAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTILGVLVLLFVPSYMVVVFFKTVFLVVAIGLLHGLFILPIILS 789


                  ..
gi 2245401946 904 FF 905
Cdd:pfam02460 790 LF 791
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 78-905 2.04e-63

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 233.26  E-value: 2.04e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946   78 LSSCFLRLGALVGANPWLFLLGPVLLTASLGTGLIFLPKEKENLEEQYTPiGSPAKAERRFVQSHFSTndSYR-----FS 152
Cdd:TIGR00917  309 LARFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAP-GSRAALEKQYFDTHFGP--FYRieqliIA 385

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  153 ASRTSSETNFASILvvshrdsllEPEAFAEVSRLDRAVQALKVVQENGTQILYPEVCAKYSVGCVPPNPLLFSWQQNSSl 232
Cdd:TIGR00917  386 TVQTSSHEKAPEIL---------TDDNLKLLFDIQKKVSQLFANYEGELITLDSPCFKPNHPYNCFIYSTCKKLQNMYS- 455

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  233 NLSELTFPIHSVADHLIHL----------AGFFGGNVLGYATTG--NRQRLVESRAMRLLYYLKT--EDPEDRERSQAWL 298
Cdd:TIGR00917  456 KLKPENYDDYGGVDYVKYCfehftspescLSAFGGPVDPTTVLGgfSGNNFSEASAFVVTFPVNNfvNKTNKTEKAVAWE 535

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  299 THFLDHFNDMKSDLALEDIEVVYFTSLSRQLEFEATSKT----VIPLFHLAYILIILFAVVSCSRLdCIRNKMWVAVFGV 374
Cdd:TIGR00917  536 KAFIQLAKDELLPMVQATISFSAERSIEDELKRESTADVitiaISYLVMFAYISLTLGDSPRLKSL-YVTSKVLLGLSGI 614

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  375 FSVAMSVVSGFGLMLHIGVPFVIIVANS-PFLILGVGVDDMFIMISAWQ-----------KTSLTESVSERLSNSYSKVA 442
Cdd:TIGR00917  615 LIVMLSVLGSVGVFSAVGLKSTLIIMEViPFLVLAVGVDNIFILVFFYFyleyfyrqvgvDNEQELTLERRLSRALMEVG 694

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  443 VSITITTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAIMALDGKRevvwsrwlekpdQKYSSFKKFCC 522
Cdd:TIGR00917  695 PSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKR------------TEDKRVDCFPC 762

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  523 VPF--GSFPDEHGDDNHPMNL---FFRDYFGPFLTTSKAKFIVVLIYIFYIISSIYGCFQVQEGLDLRNLASDDSYITPY 597
Cdd:TIGR00917  763 IKTskSSISAEKGSGQRKAGLltrYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIY 842

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  598 FNVEEDYFsDYGPRVMVIVTETVNYWDKDVRQKL--------DKCMTQFEQNEYVDKNLTEfWLEAYMQYM--------- 660
Cdd:TIGR00917  843 FASLTPLL-EVGPPFYIVIKGDYNYTDFESQNKLctmggcdkDSIVNVFNNLSYIAKPASS-WLDDYLVWLspqascccr 920

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  661 -NNTG---NNPNDK----NTFMNNIAG------FLNFFPVFTYDIN-----------VSSSNEITSSRGFIQ-------- 707
Cdd:TIGR00917  921 kFTNGtfcNGPDPQcfrcADLSSDAQGrpsttqFKEKLPWFLNALPsadcakgghaaYSSAVDLQGYATIIQassfrtyh 1000

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  708 -----TIDVSSSSNKKRMLLKlrGIAENCEVPLMVYNQAFIYFDQYAAIIENTVRNVMIASTAMFIVSLLLIPhpvCSLW 782
Cdd:TIGR00917 1001 tplntQVDFINAMRAAQEFAA--KVSRSSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQ---LNAL 1075

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  783 VTF----AIASVIVGVTGFMAFWNVNLDSISMINLVICIGFSFDFSAHISYAFVSSNEPSVNKKSIEALYLLGYPVLQS- 857
Cdd:TIGR00917 1076 SVVnlimSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFSGi 1155

                          890       900       910       920
                   ....*....|....*....|....*....|....*....|....*....
gi 2245401946  858 AISTIIGVCVLAAAKAYIFRTFFKIMFLVM-FFGAAHGLIFIPVFLTFF 905
Cdd:TIGR00917 1156 TLTKLVGVVVLGFSRSEIFVVYYFRMYLALvLLGFLHGLVFLPVLLSVL 1204
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 362-500 1.09e-37

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 138.10  E-value: 1.09e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 362 CIRNKMWVAVFGVFSVAMSVVSGFGLMLHIGVPFVIIVANS-PFLILGVGVDDMFIMISAWQKTSLTESVSERLSNSYSK 440
Cdd:pfam12349   1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEViPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 441 VAVSITITTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAIMALDGKRE 500
Cdd:pfam12349  81 VGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRL 140
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
346-905 2.01e-34

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 142.71  E-value: 2.01e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  346 YILIILFAVVSCSRLDCIRNKMWVAVFGVFSVAMSVVSGFGLMLHIGVPFVIIVANS-PFLILGVGVDDMFIMISAWQKT 424
Cdd:TIGR00918  406 YLLMLAYACLTMLRWDCAKSQGSVGLAGVLLVALSVAAGLGLCALLGISFNAATTQVlPFLALGVGVDDVFLLAHAFSET 485

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  425 SLTESVSERLSNSYSKVAVSITITTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAIMALDGKRevvws 504
Cdd:TIGR00918  486 GQNIPFEERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRR----- 560

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  505 rwleKPDQKYSSFkkFCCVPFGSF------PDEHGDDNHP---------------------------------------- 538
Cdd:TIGR00918  561 ----REDRRLDIF--CCFFSPCSArviqiePQAYADGSAPpvysshmqstvqlrteydpgtqhyyttneprshlsvqpsd 634

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  539 ------------------------------------MNLFFRDYFGPFLTTSKAKFIVVLIYIFYIISSIYGCFQVQEGL 582
Cdd:TIGR00918  635 plscqspdiagstrdllsqfedskaaclslpcarwtLATFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGL 714

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  583 DLRNLASDDSYITPYFNVEEDYFSDYGprvMVIVTE-TVNYwdKDVRQKLDKCMTQFEQNEYVDKN----LTEFWLEAYM 657
Cdd:TIGR00918  715 DLTDIVPRDTNEHDFLDAQFRYFSFYN---MYAVTQgNFDY--PTQQQLLYDLHQSFSSVKYVLKEdngqLPRMWLHYFR 789

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  658 QYMNN-----------------------------------TGN--NPNDKNTFMN----NIAGFLNFFPVFTYdINVSSS 696
Cdd:TIGR00918  790 DWLQGlqkafdedwrdgritkenyrngsddavlaykllvqTGHrdKPVDKEQLTTqrlvNADGIINPNAFYIY-LSAWVS 868

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  697 NEI---TSSRG---------FIQTIDVSSSSNK---------KRMLLKLRGIAENCEVPLMV---------YNQA----- 741
Cdd:TIGR00918  869 NDPvayAASQAniyphppewLHDKNDYDPENLRipaaepleyAQFPFYLNGLRETSQFVEAIehvraicnnYEGFglpsy 948

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  742 -----FIYFDQYAAIIENTVRNVMIASTAMFIVSLLLIPHPVCSLWVTFAIASVIVGVTGFMAFWNVNLDSISMINLVIC 816
Cdd:TIGR00918  949 psgypFLFWEQYMGLRHWLLLSISVVLACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIAS 1028

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  817 IGFSFDFSAHISYAFVSSnEPSVNKKSIEALYLLGYPVLQSAISTIIGVCVLAAAK-AYIFRTFFKIMFLVMFFGAAHGL 895
Cdd:TIGR00918 1029 VGIGVEFTVHIALGFLTA-IGDRNRRAVLALEHMFAPVLDGALSTLLGVLMLAGSEfDFIVRYFFAVLAVLTCLGVLNGL 1107

                          730
                   ....*....|
gi 2245401946  896 IFIPVFLTFF 905
Cdd:TIGR00918 1108 VLLPVLLSMF 1117
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
82-905 1.47e-26

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 116.50  E-value: 1.47e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  82 FLRLGALVGANPWLFLLGPVLLTASLGTGLIFLpkEKENLEEQYTPIGSPAKAERRFVQSHFSTNDSyrfsasrtssetn 161
Cdd:COG1033     4 MERLARFILRHRKLVLLLFLLLTLLLAYGAPKL--EVDTDFESLLPEDDPSVQAYDEFEEEFGGDDT------------- 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 162 faSILVVSHRDSLLEPEAFAEVSRLDRAVQALKVVQE--NGTQILYPEVcakysvgcvPPNPLLFSWQQNSSLNLSELTF 239
Cdd:COG1033    69 --VVVAVEGKDDIFTPETLEALRELTEELEEIPGVDSvtSLTNVRATEG---------TEDGLTVEPLIPDELPASPEEL 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 240 PihSVADHLIHLAGFFGGNVLGYATTgnrqrlvesrAMRLLYYLKTEDPEDRERSQAwlthfLDHFNDMKSDLALEDIEV 319
Cdd:COG1033   138 A--ELREKVLSSPLYVGRLVSPDGKA----------TLIVVTLDPDPLSSDLDRKEV-----VAEIRAIIAKYEDPGVEV 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 320 VYF-TSLSRQLEFEATSKTVIPLFHLAYILIILFAVVSCSRLdcirnkmWVAVFGVFSVAMSVVSGFGLMLHIGVPFVII 398
Cdd:COG1033   201 YLTgFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSL-------RGVLLPLLVVLLAVIWTLGLMGLLGIPLSPL 273

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 399 VANSPFLILGVGVDDMFIMISAWQK-TSLTESVSERLSNSYSKVAVSITITTITNVLAFYTGITSSFRSVQYFCIYTGTT 477
Cdd:COG1033   274 TILVPPLLLAIGIDYGIHLLNRYREeRRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIG 353

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 478 LLFCYFYSITCFGAIMALdgkrevvwsrwLEKPDQKYSSFKKfccvpfgsfpdeHGDDNHPMNLFFRdyfgpfLTTSKAK 557
Cdd:COG1033   354 VLLAFLTSLTLLPALLSL-----------LPRPKPKTRRLKK------------PPELGRLLAKLAR------FVLRRPK 404

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 558 FIVVLIYIFYIISSIyGCFQVQ-EGLDLRNLASDDSYITPYFNVEEDYFSDYGPRVMVIVTETVNYWDKDVRQKLDKCMT 636
Cdd:COG1033   405 VILVVALVLAVVSLY-GISRLKvEYDFEDYLPEDSPIRQDLDFIEENFGGSDPLEVVVDTGEPDGLKDPEVLKEIDRLQD 483

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 637 QFEQNEYVDKNLTefwLEAYMQYMNNTGNNPNDKNTFMNNIAGFLNFFPVFTYDINVSSSNEITS---SRGFIQ-TIDVS 712
Cdd:COG1033   484 YLESLPEVGKVLS---LADLVKELNQALNEGDPKYYALPESRELLAQLLLLLSSPPGDDLSRFVDedySAARVTvRLKDL 560

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 713 SSSNKKRMLLKLR-GIAENCEVPLMVYN---QAFIYFDQYAAIIENTVRNVMIASTAMFIVSLLL---IPHPVCSLwvtF 785
Cdd:COG1033   561 DSEEIKALVEEVRaFLAENFPPDGVEVTltgSAVLFAAINESVIESQIRSLLLALLLIFLLLLLAfrsLRLGLISL---I 637

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 786 AIASVIVGVTGFMAFWNVNLDSISMINLVICIGFSFDFSAHISYAFVSsnEPSVNKKSIEALYLL----GYPVLQSAIST 861
Cdd:COG1033   638 PNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYRE--ERRKGGDLEEAIRRAlrttGKAILFTSLTL 715

                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....
gi 2245401946 862 IIGVCVLAAAKAYIFRTFFKIMFLVMFFGAAHGLIFIPVFLTFF 905
Cdd:COG1033   716 AAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLL 759
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
56-495 1.44e-12

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 71.43  E-value: 1.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946  56 LPPVGQEAPPPRRCHTDCLEAPLSSCFL-RLGALVGANPWLFLLGPVLLTASLGTGLIFLpkEKENLEEQYTPIGSPAKA 134
Cdd:COG1033   365 LPALLSLLPRPKPKTRRLKKPPELGRLLaKLARFVLRRPKVILVVALVLAVVSLYGISRL--KVEYDFEDYLPEDSPIRQ 442

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 135 ERRFVQSHFSTNDSYrfsasrtssetnfaSILV-VSHRDSLLEPEAFAEVSRLDRAVQALKVVQ---------ENGTQIL 204
Cdd:COG1033   443 DLDFIEENFGGSDPL--------------EVVVdTGEPDGLKDPEVLKEIDRLQDYLESLPEVGkvlsladlvKELNQAL 508

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 205 YPEVCAKYSVgcvPPNpllfswQQNSSLNLSELTFPIHSVADHLIHlagffggnvlgyattgnrqrlVESRAMRLLYYLK 284
Cdd:COG1033   509 NEGDPKYYAL---PES------RELLAQLLLLLSSPPGDDLSRFVD---------------------EDYSAARVTVRLK 558

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 285 TEDPEDRERSQAWLTHFLDhfndmksDLALEDIEVVYFTSLSRQleFEATSKTV----IPLFHLAYILIILFAVVScsrl 360
Cdd:COG1033   559 DLDSEEIKALVEEVRAFLA-------ENFPPDGVEVTLTGSAVL--FAAINESViesqIRSLLLALLLIFLLLLLA---- 625

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 361 dcIRNkMWVAVFGVFSVAMSVVSGFGLMLHIGVPF----VIIVAnspfLILGVGVDDMFIMISAW-QKTSLTESVSERLS 435
Cdd:COG1033   626 --FRS-LRLGLISLIPNLLPILLTFGLMGLLGIPLniatAVVAS----IALGIGVDYTIHFLSRYrEERRKGGDLEEAIR 698

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 436 NSYSKVAVSITITTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAIMAL 495
Cdd:COG1033   699 RALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLL 758
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 320-495 4.49e-06

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 50.61  E-value: 4.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 320 VYFTSLSRQLEFEATSKTVIPLFhlaYILIILFAVvscsrldcIRNKMwVAVFGVfsVAMSVVSGF--GLMLHIGVPFVI 397
Cdd:TIGR00921 556 VAFAEMHELVNEGMRRMTIAGAI---LVLMILLAV--------FRNPI-KAVFPL--IAIGSGILWaiGLMGLRGIPSFL 621

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 398 IVANSPFLILGVGVDDMFIMISAWQKTSLTESVSERLSNSYSKVAVSITITTITNVLAFYTGITSSFRSVQYFCIYTGTT 477
Cdd:TIGR00921 622 AMATTISIILGLGMDYSIHLAERYFEERKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIG 701

                         170
                  ....*....|....*...
gi 2245401946 478 LLFCYFYSITCFGAIMAL 495
Cdd:TIGR00921 702 VLSSLTAALVVFPALLVL 719
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 574-905 5.19e-06

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 50.22  E-value: 5.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 574 GCFQVQEGLDLRNLASDDSYITP-YFNVEEDYFSdyGPRVMVIVTETVNYWDKDVRQKLDKCMTQFEQNEYVDKNlteFW 652
Cdd:TIGR00921  21 GAQHLNVESDTEKQLPKDFESYKwYHVLQREFGT--STKTLLVVIEGDDVTRKPVLDYMRRLEQRLREKPYVTNV---RS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 653 LEAYMQYMNNTGNNPNDkntfMNNIAGFLNFFPVFtYDINVSSSNEITssrgfIQTIDVSSSSNKKrmllKLRGIAENCE 732
Cdd:TIGR00921  96 AADIMRQIPGNFPLPVT----MPEVRPLMSEYPRS-KEMFLSKDHTVA-----IIIVQLKSDADYK----QVVPIYNDVE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 733 -----------VPLMVYNQAFIYFDQYAAIIENTVRNVMIASTAMFIVSLLLIPHPVCSLWVTFAIASVIVGVTGFMAFW 801
Cdd:TIGR00921 162 rslertnppsgKFLDVTGSPAINYDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 802 NVNLDSISMINLVICIGFSFDFSAHISYAFvsSNEPSVNKKSIEALYL----LGYPVLQSAISTIIGVCVLAAAKAYIFR 877
Cdd:TIGR00921 242 GIPLYATTLLAVPMLIGVGIDYGIQTLNRY--EEERDIGRAKGEAIVTavrrTGRAVLIALLTTSAGFAALALSEFPMVS 319

                         330       340
                  ....*....|....*....|....*...
gi 2245401946 878 TFFKIMFLVMFFGAAHGLIFIPVFLTFF 905
Cdd:TIGR00921 320 EFGLGLVAGLITAYLLTLLVLPALLQSI 347
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 368-487 2.79e-05

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 47.91  E-value: 2.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 368 WVAVFGVFSVAMSVVSGFGLMLHIGVPFVIIVANSPFLILGVGVD-DMFIMISAWQKTSLTESVSERLSNSYSKVAVSIT 446
Cdd:TIGR00921 218 WRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDyGIQTLNRYEEERDIGRAKGEAIVTAVRRTGRAVL 297

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 2245401946 447 ITTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSIT 487
Cdd:TIGR00921 298 IALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLL 338
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 367-507 7.51e-03

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 39.98  E-value: 7.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2245401946 367 MWVAVFG---VFSVAMSVVSG------FGLMLhIGVPFVIIVANSPFLIlGVGVDdmF-IMISAWQKTSLTESVSER--L 434
Cdd:TIGR03480 286 LWLALRSprlVFAVLVTLIVGliltaaFATLA-VGHLNLISVAFAVLFI-GLGVD--FaIQFSLRYREERFRGGNHReaL 361

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2245401946 435 SNSYSKVAVSITITTITNVLAFYTGITSSFRSVQYFCIYTGTTLLFCYFYSITCFGAIMAL---DGKREVVWSRWL 507
Cdd:TIGR03480 362 SVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFIALFVTLTVLPALLRLlrpPRRRKPPGYATL 437
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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