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Conserved domains on  [gi|4504483|ref|NP_000185|]
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hypoxanthine-guanine phosphoribosyltransferase [Homo sapiens]

Protein Classification

type I phosphoribosyltransferase( domain architecture ID 27)

type I phosphoribosyltransferase similar to phosphoribosyltransferases with specificities for hypoxanthine, guanine, and/or xanthine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRTases_typeI super family cl00309
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 8-218 9.93e-95

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


The actual alignment was detected with superfamily member PTZ00149:

Pssm-ID: 444823  Cd Length: 241  Bit Score: 276.65  E-value: 9.93e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483     8 VVISDDEpGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNR 87
Cdd:PTZ00149  30 IYIKDDD-FYDLDSFLIPPHYKNYLTKILLPNGLIKDRVEKLAYDIKQVYGNEELHILCILKGSRGFFSALVDYLNRIHN 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483    88 NSDRSIPMTV---DFIRLKSYCNDQSTGDIKVIGgDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLL 164
Cdd:PTZ00149 109 YSSTESPKPPyqeHYVRVKSYCNDESTGKLEIVS-DDLSCLKDKHVLIVEDIIDTGNTLVKFCEYLKKFEPKTIRIATLF 187

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 4504483   165 VKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 218
Cdd:PTZ00149 188 EKRTPLSNGFKGDFVGFSIPDHFVVGYCLDYNEHFRDLDHVAVLNDEGIKKYKK 241
 
Name Accession Description Interval E-value
PTZ00149 PTZ00149
hypoxanthine phosphoribosyltransferase; Provisional
 8-218 9.93e-95

hypoxanthine phosphoribosyltransferase; Provisional


Pssm-ID: 240293  Cd Length: 241  Bit Score: 276.65  E-value: 9.93e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483     8 VVISDDEpGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNR 87
Cdd:PTZ00149  30 IYIKDDD-FYDLDSFLIPPHYKNYLTKILLPNGLIKDRVEKLAYDIKQVYGNEELHILCILKGSRGFFSALVDYLNRIHN 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483    88 NSDRSIPMTV---DFIRLKSYCNDQSTGDIKVIGgDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLL 164
Cdd:PTZ00149 109 YSSTESPKPPyqeHYVRVKSYCNDESTGKLEIVS-DDLSCLKDKHVLIVEDIIDTGNTLVKFCEYLKKFEPKTIRIATLF 187

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 4504483   165 VKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 218
Cdd:PTZ00149 188 EKRTPLSNGFKGDFVGFSIPDHFVVGYCLDYNEHFRDLDHVAVLNDEGIKKYKK 241
HGPRTase TIGR01203
hypoxanthine phosphoribosyltransferase; Alternate name: hypoxanthine-guanine ...
 35-209 1.14e-78

hypoxanthine phosphoribosyltransferase; Alternate name: hypoxanthine-guanine phosphoribosyltransferase. Sequence differences as small as a single residue can affect whether members of this family act on hypoxanthine and guanine or hypoxanthine only. The designation of this model as equivalog reflects hypoxanthine specificity and does not reflect whether or not guanine can replace hypoxanthine. [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 273497  Cd Length: 166  Bit Score: 232.90  E-value: 1.14e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483     35 VFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKalnrnsdrsIPMTVDFIRLKSYCND-QSTGD 113
Cdd:TIGR01203   1 VLIPEEQIKARIAELAKQITEDYAGKPLVLLCVLKGSFPFFADLIRYIA---------VPVQVDFMAVSSYGNGmQSSGD 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483    114 IKVIGGDDLSTLtGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYAL 193
Cdd:TIGR01203  72 VKILKDLDLDIK-GKDVLIVEDIVDTGLTLQYLLDLLKARKPKSLKIVTLLDKPSRRKVDVKVDFVGFEIPDKFVVGYGL 150

                         170
                  ....*....|....*.
gi 4504483    194 DYNEYFRDLNHVCVIS 209
Cdd:TIGR01203 151 DYAERYRNLPYIGVLE 166
HptA COG0634
Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; ...
 30-210 1.70e-58

Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; Hypoxanthine-guanine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440399  Cd Length: 176  Bit Score: 182.15  E-value: 1.70e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483   30 EDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLldyIKALNrnsdrsIPMTVDFIRLKSYCN-D 108
Cdd:COG0634   3 DDIAEVLISEEEIQARVKELAAQITADYAGKEPLVVGVLKGAFVFMADL---LRALD------FPLEIDFMHVSSYGGgT 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483  109 QSTGDIKVIGGDDLStLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFV 188
Cdd:COG0634  74 ESSGEVRILKDLDED-IEGRDVLIVEDIIDTGLTLSYLLELLKSRGPASVKIATLLDKPERRKVDVPADYVGFEIPDEFV 152

                       170       180
                ....*....|....*....|..
gi 4504483  189 VGYALDYNEYFRDLNHVCVISE 210
Cdd:COG0634 153 VGYGLDYAEYYRNLPYIYALKP 174
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 39-196 1.01e-18

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 79.33  E-value: 1.01e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483     39 HGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKalnrnsdrsIPMTvdFIRLKSYCNDQSTGdikVIG 118
Cdd:pfam00156   8 NPAILKAVARLAAQINEDYGGKPDVVVGILRGGLPFAGILARRLD---------VPLA--FVRKVSYNPDTSEV---MKT 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504483    119 GDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEiPDKFVVGYALDYN 196
Cdd:pfam00156  74 SSALPDLKGKTVLIVDDILDTGGTLLKVLELLKNVGPKEVKIAVLIDKPAGTEPKDKYDKRVDD-WIVFVVGFGLDER 150
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 47-182 7.01e-18

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 76.28  E-value: 7.01e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483   47 ERLARDVmKEMGGHHIVALCVLKGGYKFFADLLDYIKAlnrnsdrsipmTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLT 126
Cdd:cd06223   3 RLLAEEI-REDLLEPDVVVGILRGGLPLAAALARALGL-----------PLAFIRKERKGPGRTPSEPYGLELPLGGDVK 70

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483  127 GKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYK----PDFVGFE 182
Cdd:cd06223  71 GKRVLLVDDVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGARELAspgdPVYSLFT 130
 
Name Accession Description Interval E-value
PTZ00149 PTZ00149
hypoxanthine phosphoribosyltransferase; Provisional
 8-218 9.93e-95

hypoxanthine phosphoribosyltransferase; Provisional


Pssm-ID: 240293  Cd Length: 241  Bit Score: 276.65  E-value: 9.93e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483     8 VVISDDEpGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNR 87
Cdd:PTZ00149  30 IYIKDDD-FYDLDSFLIPPHYKNYLTKILLPNGLIKDRVEKLAYDIKQVYGNEELHILCILKGSRGFFSALVDYLNRIHN 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483    88 NSDRSIPMTV---DFIRLKSYCNDQSTGDIKVIGgDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLL 164
Cdd:PTZ00149 109 YSSTESPKPPyqeHYVRVKSYCNDESTGKLEIVS-DDLSCLKDKHVLIVEDIIDTGNTLVKFCEYLKKFEPKTIRIATLF 187

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 4504483   165 VKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 218
Cdd:PTZ00149 188 EKRTPLSNGFKGDFVGFSIPDHFVVGYCLDYNEHFRDLDHVAVLNDEGIKKYKK 241
HGPRTase TIGR01203
hypoxanthine phosphoribosyltransferase; Alternate name: hypoxanthine-guanine ...
 35-209 1.14e-78

hypoxanthine phosphoribosyltransferase; Alternate name: hypoxanthine-guanine phosphoribosyltransferase. Sequence differences as small as a single residue can affect whether members of this family act on hypoxanthine and guanine or hypoxanthine only. The designation of this model as equivalog reflects hypoxanthine specificity and does not reflect whether or not guanine can replace hypoxanthine. [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 273497  Cd Length: 166  Bit Score: 232.90  E-value: 1.14e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483     35 VFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKalnrnsdrsIPMTVDFIRLKSYCND-QSTGD 113
Cdd:TIGR01203   1 VLIPEEQIKARIAELAKQITEDYAGKPLVLLCVLKGSFPFFADLIRYIA---------VPVQVDFMAVSSYGNGmQSSGD 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483    114 IKVIGGDDLSTLtGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYAL 193
Cdd:TIGR01203  72 VKILKDLDLDIK-GKDVLIVEDIVDTGLTLQYLLDLLKARKPKSLKIVTLLDKPSRRKVDVKVDFVGFEIPDKFVVGYGL 150

                         170
                  ....*....|....*.
gi 4504483    194 DYNEYFRDLNHVCVIS 209
Cdd:TIGR01203 151 DYAERYRNLPYIGVLE 166
HptA COG0634
Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; ...
 30-210 1.70e-58

Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; Hypoxanthine-guanine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440399  Cd Length: 176  Bit Score: 182.15  E-value: 1.70e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483   30 EDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLldyIKALNrnsdrsIPMTVDFIRLKSYCN-D 108
Cdd:COG0634   3 DDIAEVLISEEEIQARVKELAAQITADYAGKEPLVVGVLKGAFVFMADL---LRALD------FPLEIDFMHVSSYGGgT 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483  109 QSTGDIKVIGGDDLStLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFV 188
Cdd:COG0634  74 ESSGEVRILKDLDED-IEGRDVLIVEDIIDTGLTLSYLLELLKSRGPASVKIATLLDKPERRKVDVPADYVGFEIPDEFV 152

                       170       180
                ....*....|....*....|..
gi 4504483  189 VGYALDYNEYFRDLNHVCVISE 210
Cdd:COG0634 153 VGYGLDYAEYYRNLPYIYALKP 174
PLN02238 PLN02238
hypoxanthine phosphoribosyltransferase
 28-210 1.90e-42

hypoxanthine phosphoribosyltransferase


Pssm-ID: 215132  Cd Length: 189  Bit Score: 141.71  E-value: 1.90e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483    28 YAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRnsdrsiPMTVDFIRLKSY-C 106
Cdd:PLN02238   3 YEVDIEKVLWTAEDISARVAELAAQIASDYAGKSPVVLGVATGAFMFLADLVRAIQPLPR------GLTVDFIRASSYgG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483   107 NDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYK-----PDFVGF 181
Cdd:PLN02238  77 GTESSGVAKVSGADLKIDVKGKHVLLVEDIVDTGNTLSALVAHLEAKGAASVSVCALLDKRARRKVKYElvgdgKEYVGF 156

                        170       180
                 ....*....|....*....|....*....
gi 4504483   182 EIPDKFVVGYALDYNEYFRDLNHVCVISE 210
Cdd:PLN02238 157 ECPDEFVVGYGLDFAEKYRNLPYVGVLKP 185
PRK15423 PRK15423
hypoxanthine phosphoribosyltransferase; Provisional
 35-205 1.27e-24

hypoxanthine phosphoribosyltransferase; Provisional


Pssm-ID: 185321  Cd Length: 178  Bit Score: 95.47  E-value: 1.27e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483    35 VFIPHGLIMDRTERLARDVMKEM--GGHHIVALCVLKGGYKFFADLLDYIKalnrnsdrsIPMTVDFIRLKSYCNDQSTG 112
Cdd:PRK15423   7 VMIPEAEIKARIAELGRQITERYkdSGSDMVLVGLLRGSFMFMADLCREVQ---------VSHEVDFMTASSYGSGMSTT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483   113 -DIKVIGGDDlSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGY 191
Cdd:PRK15423  78 rDVKILKDLD-EDIRGKDVLIVEDIIDSGNTLSKVREILSLREPKSLAICTLLDKPSRREVNVPVEFIGFSIPDEFVVGY 156

                        170
                 ....*....|....
gi 4504483   192 ALDYNEYFRDLNHV 205
Cdd:PRK15423 157 GIDYAQRYRHLPYI 170
PTZ00271 PTZ00271
hypoxanthine-guanine phosphoribosyltransferase; Provisional
 65-210 2.00e-23

hypoxanthine-guanine phosphoribosyltransferase; Provisional


Pssm-ID: 140297  Cd Length: 211  Bit Score: 93.16  E-value: 2.00e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483    65 LCVLKGGYKFFADLLDYIkalnrnSDRSIPMTVDFIRLKSYCND-QSTGDIKVIGgDDLSTLTGKNVLIVEDIIDTGKTM 143
Cdd:PTZ00271  62 LCVLKGSFIFTADLARFL------ADEGVPVKVEFICASSYGTGvETSGQVRMLL-DVRDSVENRHILIVEDIVDSAITL 134

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4504483   144 QTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISE 210
Cdd:PTZ00271 135 QYLMRFMLAKKPASLKTVVLLDKPSGRKVEVLVDYPVITIPHAFVIGYGMDYAESYRELRDICVLKK 201
PRK09162 PRK09162
hypoxanthine-guanine phosphoribosyltransferase; Provisional
 47-202 2.48e-23

hypoxanthine-guanine phosphoribosyltransferase; Provisional


Pssm-ID: 181675  Cd Length: 181  Bit Score: 92.23  E-value: 2.48e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483    47 ERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKAlnrnsdrsiPMTVDFIRLKSYCNDQSTGDI--KVIGGDDLSt 124
Cdd:PRK09162  27 DRMADEITADLADENPLVLCVMGGGLVFTGQLLPRLDF---------PLEFDYLHATRYRNETTGGELvwKVKPRESLK- 96

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4504483   125 ltGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSV-GYKPDFVGFEIPDKFVVGYALDYNEYFRDL 202
Cdd:PRK09162  97 --GRTVLVVDDILDEGHTLAAIRDRCLEMGAAEVYSAVLVDKTHDRKAkPLKADFVGLEVPDRYVFGYGMDYKGYWRNL 173
Hpt1 COG2236
Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine ...
 42-185 2.90e-20

Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 441837 [Multi-domain]  Cd Length: 153  Bit Score: 83.36  E-value: 2.90e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483   42 IMDRTERLARDVMKEmGGHHIVALCVLKGGYkFFADLLDYikALNrnsdrsIPMtVDFIRLKSYCNDQSTGDIKVIGGDD 121
Cdd:COG2236  14 IHELSRRLAEQILES-GFRPDVIVAIARGGL-VPARILAD--ALG------VPD-LASIRVSSYTGTAKRLEEPVVKGPL 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4504483  122 LSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKrtPRSVgYKPDFVGFEIPD 185
Cdd:COG2236  83 DEDLAGKRVLIVDDVADTGRTLEAVRDLLKEAGPAEVRTAVLYYK--PSSK-FKPDYYAEETDA 143
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 39-196 1.01e-18

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 79.33  E-value: 1.01e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483     39 HGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKalnrnsdrsIPMTvdFIRLKSYCNDQSTGdikVIG 118
Cdd:pfam00156   8 NPAILKAVARLAAQINEDYGGKPDVVVGILRGGLPFAGILARRLD---------VPLA--FVRKVSYNPDTSEV---MKT 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4504483    119 GDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEiPDKFVVGYALDYN 196
Cdd:pfam00156  74 SSALPDLKGKTVLIVDDILDTGGTLLKVLELLKNVGPKEVKIAVLIDKPAGTEPKDKYDKRVDD-WIVFVVGFGLDER 150
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 47-182 7.01e-18

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 76.28  E-value: 7.01e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483   47 ERLARDVmKEMGGHHIVALCVLKGGYKFFADLLDYIKAlnrnsdrsipmTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLT 126
Cdd:cd06223   3 RLLAEEI-REDLLEPDVVVGILRGGLPLAAALARALGL-----------PLAFIRKERKGPGRTPSEPYGLELPLGGDVK 70

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4504483  127 GKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYK----PDFVGFE 182
Cdd:cd06223  71 GKRVLLVDDVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGARELAspgdPVYSLFT 130
PRK07322 PRK07322
adenine phosphoribosyltransferase; Provisional
 116-164 7.59e-05

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 180928  Cd Length: 178  Bit Score: 41.89  E-value: 7.59e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 4504483   116 VIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLL 164
Cdd:PRK07322 109 VLDGADAEKLKGKRVAIVDDVVSTGGTLTALERLVERAGGQVVAKAAIF 157
PRK08558 PRK08558
adenine phosphoribosyltransferase; Provisional
 127-163 2.41e-04

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 181466 [Multi-domain]  Cd Length: 238  Bit Score: 40.75  E-value: 2.41e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 4504483   127 GKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASL 163
Cdd:PRK08558 176 GDRVLIVDDIIRSGETQRALLDLARQAGADVVGVFFL 212
PRK09177 PRK09177
xanthine-guanine phosphoribosyltransferase; Validated
 97-156 2.60e-04

xanthine-guanine phosphoribosyltransferase; Validated


Pssm-ID: 236395  Cd Length: 156  Bit Score: 39.84  E-value: 2.60e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4504483    97 VDFIRLKSYcNDQSTGDIKV---IGGDdlstltGKNVLIVEDIIDTGKTMQtllsLVRQYNPK 156
Cdd:PRK09177  58 VDTVCISSY-DHDNQGELKVlkrAEGD------GEGFLVVDDLVDTGGTAR----AVREMYPK 109
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 125-161 2.93e-04

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 40.67  E-value: 2.93e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 4504483   125 LTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVA 161
Cdd:PRK00934 202 VKGKDVLIVDDIISTGGTMATAIKILKEQGAKKVYVA 238
Apt COG0503
Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide ...
 110-164 2.74e-03

Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide transport and metabolism]; Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440269  Cd Length: 171  Bit Score: 37.36  E-value: 2.74e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 4504483  110 STGDIKVIGGDDLSTltGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLL 164
Cdd:COG0503  97 GTGDTLELHKDALKP--GDRVLIVDDLLATGGTAKAAIKLVEEAGAEVVGIAFLI 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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