NCBI Conserved Domain Search

Conserved domains on [gi|116174762|ref|NP_001001810|]

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olfactory receptor 1206 [Mus musculus]

Protein Classification

olfactory receptor family 4A protein( domain architecture ID 11610412)

olfactory receptor family 4A protein is an odorant receptor belonging to the G-protein coupled receptor 1 family

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

23-289

4.15e-162

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 451.67 E-value: 4.15e-162

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  23 KMVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFAL 102
Cdd:cd15939    1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 103 HLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPL 182
Cdd:cd15939   81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 183 LKLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHSLRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTT 262
Cdd:cd15939  161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                        250       260
                 ....*....|....*....|....*..
gi 116174762 263 FSMDKMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd15939  241 FPIDKVVAVFYTIITPMLNPLIYTLRN 267

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

23-289

4.15e-162

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 451.67 E-value: 4.15e-162

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  23 KMVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFAL 102
Cdd:cd15939    1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 103 HLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPL 182
Cdd:cd15939   81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 183 LKLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHSLRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTT 262
Cdd:cd15939  161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                        250       260
                 ....*....|....*....|....*..
gi 116174762 263 FSMDKMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd15939  241 FPIDKVVAVFYTIITPMLNPLIYTLRN 267

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

29-299

2.06e-39

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 139.56 E-value: 2.06e-39

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762   29 FLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFGCM 108
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  109 EIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKLACM 188
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  189 DTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYAR-------PP 260
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTvLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVhrfghnvPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 116174762  261 TtfsMDKMVAVFYTIGTPFLNPIIYTLRNAEVKNAMKKL 299
Cdd:pfam13853 241 L---LQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRM 276

COG5543

Uncharacterized conserved protein [Function unknown];

121-291

8.01e-03

Uncharacterized conserved protein [Function unknown];

Pssm-ID: 227830 [Multi-domain] Cd Length: 1400 Bit Score: 38.06 E-value: 8.01e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  121 YVAICKPLRYPVIMSRQVCVIL-----IILAWIGSFIHSTAQIVLALRLPFCGPNLIDHyccDLQPLLKLACMDTYM--- 192
Cdd:COG5543   414 YLEVIKPMLRPTNAYQRVLGSLylmdsLIAEGIDKSTPQKFLIQNKREFPFSAQLLFDS---DHERLMIDLLVSNYAdir 490

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  193 -----INLLLVSNSGAICSSSFVILIISYFVILHSLRNHSAEGRKKALSTCTSHIIVVI--LFFGPCIFIYARPPTTFSM 265
Cdd:COG5543   491 klstkILLGLESMSESRGLFLDTLDANALKVKIESHQSHDVHGDAGATVYCVEFIKSCQsrSFVGHTKSILDSHMKNFVS 570

                         170       180
                  ....*....|....*....|....*..
gi 116174762  266 DKMVAVFYTIGTPFLN-PIIYTLRNAE 291
Cdd:COG5543   571 GKKSMEEISIGPHFAAlSLILGLFNSE 597

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

23-289

4.15e-162

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 451.67 E-value: 4.15e-162

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  23 KMVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFAL 102
Cdd:cd15939    1 KICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 103 HLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPL 182
Cdd:cd15939   81 HFFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 183 LKLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHSLRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTT 262
Cdd:cd15939  161 LKLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTT 240

                        250       260
                 ....*....|....*....|....*..
gi 116174762 263 FSMDKMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd15939  241 FPIDKVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

26-289

4.66e-127

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 363.06 E-value: 4.66e-127

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15226    4 FVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLHFF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKL 185
Cdd:cd15226   84 GGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVIKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHSLRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTFSM 265
Cdd:cd15226  164 ACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTFPV 243

                        250       260
                 ....*....|....*....|....
gi 116174762 266 DKMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd15226  244 DKFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

26-289

2.19e-115

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 333.68 E-value: 2.19e-115

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd13954    4 FVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFFFSL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKL 185
Cdd:cd13954   84 GGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTFS 264
Cdd:cd13954  164 SCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTiLKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSSSYS 243

                        250       260
                 ....*....|....*....|....*..
gi 116174762 265 --MDKMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd13954  244 sdLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

26-289

1.29e-112

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 326.60 E-value: 1.29e-112

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15936    4 FLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFT 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKL 185
Cdd:cd15936   84 GGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHSLRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTFSM 265
Cdd:cd15936  164 ACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTFPM 243

                        250       260
                 ....*....|....*....|....
gi 116174762 266 DKMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd15936  244 DKAVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

26-289

2.28e-111

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 323.24 E-value: 2.28e-111

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15940    4 FMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKL 185
Cdd:cd15940   84 ACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHSLRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTFSM 265
Cdd:cd15940  164 ACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSFSE 243

                        250       260
                 ....*....|....*....|....
gi 116174762 266 DKMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd15940  244 DKVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

24-296

2.90e-110

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 320.94 E-value: 2.90e-110

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALH 103
Cdd:cd15225    2 LLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLL 183
Cdd:cd15225   82 FLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 184 KLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTT 262
Cdd:cd15225  162 KLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTiLKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSS 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 116174762 263 FS--MDKMVAVFYTIGTPFLNPIIYTLRNAEVKNAM 296
Cdd:cd15225  242 YSpeTDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

26-289

1.28e-108

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 316.37 E-value: 1.28e-108

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15230    4 FVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFAVF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKL 185
Cdd:cd15230   84 GTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTFS 264
Cdd:cd15230  164 SCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITiLRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSSYS 243

                        250       260
                 ....*....|....*....|....*..
gi 116174762 265 M--DKMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd15230  244 LdqDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

10-299

2.73e-100

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 296.20 E-value: 2.73e-100

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  10 FILLGLTQDPLKQKMVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNI 89
Cdd:cd15943    2 FILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENKT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  90 ISYNECMTQVFALHLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGP 169
Cdd:cd15943   82 ISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCGS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 170 NLIDHYCCDLQPLLKLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILF 248
Cdd:cd15943  162 NVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAiLRIHSSEGRRKAFSTCASHLMAVTIF 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 116174762 249 FGPCIFIYARPPTTFSM--DKMVAVFYTIGTPFLNPIIYTLRNAEVKNAMKKL 299
Cdd:cd15943  242 YGTTLFMYLRPSSSYSLdqDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRI 294

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

26-289

8.14e-100

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 294.09 E-value: 8.14e-100

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15938    4 FALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHFV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKL 185
Cdd:cd15938   84 GAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHSLRnhSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTFSM 265
Cdd:cd15938  164 ACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTILVTIR--STEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTFPV 241

                        250       260
                 ....*....|....*....|....
gi 116174762 266 DKMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd15938  242 DKHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

22-296

1.03e-99

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 294.13 E-value: 1.03e-99

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  22 QKMVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFA 101
Cdd:cd15235    1 QPLLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 102 LHLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQP 181
Cdd:cd15235   81 FIAFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 182 LLKLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPP 260
Cdd:cd15235  161 LLKLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAvLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPS 240

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 116174762 261 TTFSMDK--MVAVFYTIGTPFLNPIIYTLRNAEVKNAM 296
Cdd:cd15235  241 SSYSADKdrVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

10-293

1.60e-98

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 291.53 E-value: 1.60e-98

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  10 FILLGLTQDPLKQKMVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNI 89
Cdd:cd15408    1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  90 ISYNECMTQVFALHLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGP 169
Cdd:cd15408   81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 170 NLIDHYCCDLQPLLKLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILF 248
Cdd:cd15408  161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATiLRMRSAEGRHKAFSTCASHLTAVTLF 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 116174762 249 FGPCIFIYARPPTTFSM--DKMVAVFYTIGTPFLNPIIYTLRNAEVK 293
Cdd:cd15408  241 YGSLAFMYLRPSSRYSLdlDKVASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

24-298

2.22e-97

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 288.44 E-value: 2.22e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALH 103
Cdd:cd15419    2 LLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFFS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLL 183
Cdd:cd15419   82 LFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 184 KLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTT 262
Cdd:cd15419  162 KLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTiLRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGAV 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 116174762 263 FSM--DKMVAVFYTIGTPFLNPIIYTLRNAEVKNAMKK 298
Cdd:cd15419  242 SSPeqSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

26-289

3.17e-97

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 287.43 E-value: 3.17e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15227    4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKL 185
Cdd:cd15227   84 AASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTFS 264
Cdd:cd15227  164 SCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTvLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSP 243

                        250       260
                 ....*....|....*....|....*..
gi 116174762 265 --MDKMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd15227  244 slLDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

25-296

3.73e-97

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 287.62 E-value: 3.73e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  25 VFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHL 104
Cdd:cd15231    3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 105 FGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLK 184
Cdd:cd15231   83 FVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 185 LACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTF 263
Cdd:cd15231  163 LSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTiLKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGY 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 116174762 264 S--MDKMVAVFYTIGTPFLNPIIYTLRNAEVKNAM 296
Cdd:cd15231  243 SldKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

10-299

4.64e-97

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 288.02 E-value: 4.64e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  10 FILLGLTQDPLKQKMVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNI 89
Cdd:cd15410    1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  90 ISYNECMTQVFALHLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGP 169
Cdd:cd15410   81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 170 NLIDHYCCDLQPLLKLACMDTYMINLLLVSNSGAICSSSFVILIISY-FVILHSLRNHSAEGRKKALSTCTSHIIVVILF 248
Cdd:cd15410  161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYvFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 116174762 249 FGPCIFIYARPPTTFSM--DKMVAVFYTIGTPFLNPIIYTLRNAEVKNAMKKL 299
Cdd:cd15410  241 HGTILFMYCRPSSSYSLdtDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKL 293

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

24-296

5.31e-97

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 287.19 E-value: 5.31e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALH 103
Cdd:cd15229    2 FLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLL 183
Cdd:cd15229   82 FFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 184 KLACMDTYMINLLLVSNSGAICSSSFVILIISY-FVILHSLRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTT 262
Cdd:cd15229  162 PLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYiHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSA 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 116174762 263 --FSMDKMVAVFYTIGTPFLNPIIYTLRNAEVKNAM 296
Cdd:cd15229  242 ssSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

24-289

2.61e-96

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 285.12 E-value: 2.61e-96

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLGTVVGNTLIIMTIKF-SRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFAL 102
Cdd:cd15935    2 LLFVLVLACYAAILLGNLLIVVTVHAdPHLLQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 103 HLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPL 182
Cdd:cd15935   82 HFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 183 LKLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHSLRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTT 262
Cdd:cd15935  162 IKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSS 241

                        250       260
                 ....*....|....*....|....*..
gi 116174762 263 FSMDKMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd15935  242 SSVDKVASVFYTLITPALNPLIYTLRN 268

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

24-289

2.63e-96

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 285.15 E-value: 2.63e-96

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALH 103
Cdd:cd15912    2 LLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFYF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLL 183
Cdd:cd15912   82 FLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 184 KLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTT 262
Cdd:cd15912  162 KLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTiLRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQS 241

                        250       260
                 ....*....|....*....|....*....
gi 116174762 263 FSMD--KMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd15912  242 SSLDlnKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

26-298

1.84e-95

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 283.49 E-value: 1.84e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15416    4 FVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKL 185
Cdd:cd15416   84 GTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTFS 264
Cdd:cd15416  164 SCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAiLRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSYS 243

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 116174762 265 MD--KMVAVFYTIGTPFLNPIIYTLRNAEVKNAMKK 298
Cdd:cd15416  244 MDqnKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

24-289

1.84e-94

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 280.47 E-value: 1.84e-94

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALH 103
Cdd:cd15937    2 LLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLL 183
Cdd:cd15937   82 FLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 184 KLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHSLRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTF 263
Cdd:cd15937  162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSF 241

                        250       260
                 ....*....|....*....|....*.
gi 116174762 264 SMDKMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd15937  242 PMDKVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

26-289

6.11e-94

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 279.16 E-value: 6.11e-94

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15237    4 FILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFLAL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKL 185
Cdd:cd15237   84 GVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTFS 264
Cdd:cd15237  164 ACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATiLRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHSTHS 243

                        250       260
                 ....*....|....*....|....*..
gi 116174762 265 --MDKMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd15237  244 pdQDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

24-298

7.94e-93

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 276.83 E-value: 7.94e-93

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALH 103
Cdd:cd15417    2 ILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLL 183
Cdd:cd15417   82 GMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 184 KLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTT 262
Cdd:cd15417  162 SLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTiLKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSS 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 116174762 263 FSM--DKMVAVFYTIGTPFLNPIIYTLRNAEVKNAMKK 298
Cdd:cd15417  242 HSQdqDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

25-298

1.72e-91

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 273.42 E-value: 1.72e-91

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  25 VFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHL 104
Cdd:cd15411    3 LFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFIA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 105 FGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLK 184
Cdd:cd15411   83 LATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 185 LACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTF 263
Cdd:cd15411  163 LSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTiLKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSSY 242

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 116174762 264 S--MDKMVAVFYTIGTPFLNPIIYTLRNAEVKNAMKK 298
Cdd:cd15411  243 SlgQDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

26-298

9.27e-91

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 271.59 E-value: 9.27e-91

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15415    4 FMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKL 185
Cdd:cd15415   84 VTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTFS 264
Cdd:cd15415  164 SCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAiLRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQYS 243

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 116174762 265 MD--KMVAVFYTIGTPFLNPIIYTLRNAEVKNAMKK 298
Cdd:cd15415  244 LEqeKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

14-299

1.11e-90

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 271.55 E-value: 1.11e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  14 GLTQDPLKQKMVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYN 93
Cdd:cd15406    1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  94 ECMTQVFALHLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLID 173
Cdd:cd15406   81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 174 HYCCDLQPLLKLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPC 252
Cdd:cd15406  161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSiLRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 116174762 253 IFIYARPPTTFSMD--KMVAVFYTIGTPFLNPIIYTLRNAEVKNAMKKL 299
Cdd:cd15406  241 IFMYLKPSSSSSMTqeKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

26-298

1.61e-90

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 270.82 E-value: 1.61e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15409    4 FLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKL 185
Cdd:cd15409   84 ATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLKI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTFS 264
Cdd:cd15409  164 SCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTiLKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYA 243

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 116174762 265 M--DKMVAVFYTIGTPFLNPIIYTLRNAEVKNAMKK 298
Cdd:cd15409  244 LdqDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

26-289

4.80e-90

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 269.35 E-value: 4.80e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQvfaLHLF 105
Cdd:cd15911    4 FLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQ---FYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCM---EIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPL 182
Cdd:cd15911   81 GSLaatECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 183 LKLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPT 261
Cdd:cd15911  161 LKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTiLRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPST 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 116174762 262 TFS--MDKMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd15911  241 NTSrdLNKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

25-289

7.65e-90

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 268.79 E-value: 7.65e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  25 VFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHL 104
Cdd:cd15915    3 LFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 105 FGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLK 184
Cdd:cd15915   83 LGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 185 LACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHSL--RNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTT 262
Cdd:cd15915  163 LACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLllKVRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSG 242

                        250       260
                 ....*....|....*....|....*....
gi 116174762 263 FSM--DKMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd15915  243 DSLeqDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

24-289

3.60e-89

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 267.17 E-value: 3.60e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALH 103
Cdd:cd15431    2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIhSTAQIVLALRLPFCGPNLIDHYCCDLQPLL 183
Cdd:cd15431   82 FLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFL-LTVIPVLTMPLHFCGPNVINHFFCEVQALL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 184 KLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTT 262
Cdd:cd15431  161 KLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAvLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSK 240

                        250       260
                 ....*....|....*....|....*....
gi 116174762 263 FS--MDKMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd15431  241 SSsdQDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

26-296

5.92e-89

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 266.62 E-value: 5.92e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKK-NIISYNECMTQVFALHL 104
Cdd:cd15916    4 FLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGgKVISFGGCVAQLYFFHF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 105 FGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLK 184
Cdd:cd15916   84 LGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPLLK 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 185 LACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTF 263
Cdd:cd15916  164 LACADTTINELVIFASIGVVALGCFILILLSYGNIVRAiLRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGSKE 243

                        250       260       270
                 ....*....|....*....|....*....|...
gi 116174762 264 SMDKMVAVFYTIGTPFLNPIIYTLRNAEVKNAM 296
Cdd:cd15916  244 ALDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

26-298

1.06e-88

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 266.11 E-value: 1.06e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15413    4 FGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFLTF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKL 185
Cdd:cd15413   84 IISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLLAL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTT-- 262
Cdd:cd15413  164 SCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAiLRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSShs 243

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 116174762 263 FSMDKMVAVFYTIGTPFLNPIIYTLRNAEVKNAMKK 298
Cdd:cd15413  244 LDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

25-296

1.70e-88

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 265.57 E-value: 1.70e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  25 VFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHL 104
Cdd:cd15421    3 LFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 105 FGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLK 184
Cdd:cd15421   83 LGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 185 LACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTF 263
Cdd:cd15421  163 LSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTvLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYH 242

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 116174762 264 SM--DKMVAVFYTIGTPFLNPIIYTLRNAEVKNAM 296
Cdd:cd15421  243 SPeqDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

23-298

7.25e-88

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 263.88 E-value: 7.25e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  23 KMVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFAL 102
Cdd:cd15412    1 PLLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 103 HLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPL 182
Cdd:cd15412   81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 183 LKLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPT 261
Cdd:cd15412  161 IKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAiLRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPS 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 116174762 262 TFSM--DKMVAVFYTIGTPFLNPIIYTLRNAEVKNAMKK 298
Cdd:cd15412  241 EESVeqSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

10-298

3.92e-87

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 262.76 E-value: 3.92e-87

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  10 FILLGLTQDPLKQKMVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNI 89
Cdd:cd15945    1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  90 ISYNECMTQVFALHLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGP 169
Cdd:cd15945   81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 170 NLIDHYCCDLQPLLKLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILF 248
Cdd:cd15945  161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITvLKIRSAEGRFKAFSTCASHLTAVGLF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 116174762 249 FGPCIFIYARPPTTFSM--DKMVAVFYTIGTPFLNPIIYTLRNAEVKNAMKK 298
Cdd:cd15945  241 YGTLLFMYLRPSSSYSLdtDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

26-289

6.60e-87

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 261.39 E-value: 6.60e-87

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15918    4 FGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLLF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKL 185
Cdd:cd15918   84 GDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTFS 264
Cdd:cd15918  164 SCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAvLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSHS 243

                        250       260
                 ....*....|....*....|....*..
gi 116174762 265 M--DKMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd15918  244 AskDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

24-296

2.46e-86

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 260.06 E-value: 2.46e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALH 103
Cdd:cd15228    2 ILFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLL 183
Cdd:cd15228   82 FLGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 184 KLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTT 262
Cdd:cd15228  162 KLACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISiLKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPS 241

                        250       260       270
                 ....*....|....*....|....*....|....
gi 116174762 263 FSMDKMVAVFYTIGTPFLNPIIYTLRNAEVKNAM 296
Cdd:cd15228  242 PVLVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

26-289

5.02e-86

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 259.09 E-value: 5.02e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15947    4 FVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLWL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKL 185
Cdd:cd15947   84 GSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLLvsnsgAICSSSFVIL-----IISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARP 259
Cdd:cd15947  164 ACVDTTFNELEL-----FVASVFFLLVplsliLVSYGFIARAvLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQP 238

                        250       260       270
                 ....*....|....*....|....*....|..
gi 116174762 260 PTTFSMD--KMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd15947  239 PSSYSQDqgKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

26-296

7.80e-86

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 258.87 E-value: 7.80e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15429    4 FVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLAL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKL 185
Cdd:cd15429   84 GGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYminlllvSNSGAICSSSFVILIISYFVILHS--------LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYA 257
Cdd:cd15429  164 ACVDTS-------LNEVAILVSSVVVLLTPCFLVLLSyihiisaiLRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYM 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 116174762 258 RPPTTFS--MDKMVAVFYTIGTPFLNPIIYTLRNAEVKNAM 296
Cdd:cd15429  237 RPRSGSSalQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

26-289

8.44e-86

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 258.34 E-value: 8.44e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15232    4 FWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFTWS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKL 185
Cdd:cd15232   84 LGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLLLL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTFS 264
Cdd:cd15232  164 SCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSiLRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSSYS 243

                        250       260
                 ....*....|....*....|....*..
gi 116174762 265 M--DKMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd15232  244 PekDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

26-289

1.04e-83

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 252.97 E-value: 1.04e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15224    4 FLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLSL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKL 185
Cdd:cd15224   84 ACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLNL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPT--T 262
Cdd:cd15224  164 SCTDMSLAELVDFILALIILLVPLLVTVASYICIISTvLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAisS 243

                        250       260
                 ....*....|....*....|....*..
gi 116174762 263 FSMDKMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd15224  244 FDSNKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

10-299

1.31e-83

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 253.94 E-value: 1.31e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  10 FILLGLTQDPLKQKMVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNI 89
Cdd:cd15944    1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  90 ISYNECMTQVFALHLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGP 169
Cdd:cd15944   81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 170 NLIDHYCCDLQPLLKLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILF 248
Cdd:cd15944  161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAiLRMRSAEGRRKAFSTCASHFTGVTLF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 116174762 249 FGPCIFIYARPPTTFSM--DKMVAVFYTIGTPFLNPIIYTLRNAEVKNAMKKL 299
Cdd:cd15944  241 YGTVIFMYLRPTSVYSLdqDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKL 293

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

26-296

5.36e-83

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 251.48 E-value: 5.36e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15420    4 FGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLAL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKL 185
Cdd:cd15420   84 AHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTFS 264
Cdd:cd15420  164 ACADTWINEILIFAGCVFILLGPFSLILISYLHILAAiLKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSNS 243

                        250       260       270
                 ....*....|....*....|....*....|....
gi 116174762 265 --MDKMVAVFYTIGTPFLNPIIYTLRNAEVKNAM 296
Cdd:cd15420  244 aeQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

26-298

1.34e-82

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 250.81 E-value: 1.34e-82

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15414    4 FLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKL 185
Cdd:cd15414   84 VAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLSL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTFS 264
Cdd:cd15414  164 SCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAiLRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSSSS 243

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 116174762 265 M--DKMVAVFYTIGTPFLNPIIYTLRNAEVKNAMKK 298
Cdd:cd15414  244 LdlDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRR 279

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

24-296

4.05e-79

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 241.71 E-value: 4.05e-79

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALH 103
Cdd:cd15234    2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLL 183
Cdd:cd15234   82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 184 KLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTT 262
Cdd:cd15234  162 KLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSiLRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVT 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 116174762 263 FSMDK-MVA-VFYTIGTPFLNPIIYTLRNAEVKNAM 296
Cdd:cd15234  242 HSSRKtAVAsVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

26-296

4.26e-79

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 241.55 E-value: 4.26e-79

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15405    4 FFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKL 185
Cdd:cd15405   84 VISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTFS 264
Cdd:cd15405  164 SCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNiLHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVGS 243

                        250       260       270
                 ....*....|....*....|....*....|....
gi 116174762 265 MD--KMVAVFYTIGTPFLNPIIYTLRNAEVKNAM 296
Cdd:cd15405  244 VNqgKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

25-296

1.05e-78

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 240.41 E-value: 1.05e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  25 VFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHL 104
Cdd:cd15942    3 LFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 105 FGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLK 184
Cdd:cd15942   83 LGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 185 LACMDTYMINLLLVSNSGAICSSSFVILIISY-FVILHSLRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTF 263
Cdd:cd15942  163 LACADTAFNELVTFIDIGLVAMTCFLLILMSYvYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQD 242

                        250       260       270
                 ....*....|....*....|....*....|...
gi 116174762 264 SMDKMVAVFYTIGTPFLNPIIYTLRNAEVKNAM 296
Cdd:cd15942  243 PLDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

24-296

9.54e-78

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 238.10 E-value: 9.54e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALH 103
Cdd:cd15424    2 LLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLL 183
Cdd:cd15424   82 SLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 184 KLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARP--P 260
Cdd:cd15424  162 KLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASvLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPrsG 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 116174762 261 TTFSMDKMVAVFYTIGTPFLNPIIYTLRNAEVKNAM 296
Cdd:cd15424  242 STPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

26-298

3.37e-77

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 236.93 E-value: 3.37e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15407    4 FIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKL 185
Cdd:cd15407   84 ATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLAL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTFS 264
Cdd:cd15407  164 SCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITiLRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHS 243

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 116174762 265 M--DKMVAVFYTIGTPFLNPIIYTLRNAEVKNAMKK 298
Cdd:cd15407  244 MdtDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

26-289

6.79e-77

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 235.67 E-value: 6.79e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15913    4 FSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFSL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKL 185
Cdd:cd15913   84 GTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLAL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLLVSNSGAICSSSFVILIISYF-VILHSLRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTFS 264
Cdd:cd15913  164 SCVPAPGTELICYTLSSLIIFGTFLFILGSYTlVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGNS 243

                        250       260
                 ....*....|....*....|....*..
gi 116174762 265 --MDKMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd15913  244 tgMQKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

23-289

1.02e-75

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 232.65 E-value: 1.02e-75

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  23 KMVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFAL 102
Cdd:cd15430    1 ILLFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 103 HLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPL 182
Cdd:cd15430   81 LAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 183 LKLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPT 261
Cdd:cd15430  161 LKLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTiLRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 116174762 262 --TFSMDKMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd15430  241 knAQISDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

26-289

1.30e-75

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 232.65 E-value: 1.30e-75

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15914    4 FILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHSL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKL 185
Cdd:cd15914   84 GITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLSL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTFS 264
Cdd:cd15914  164 ACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVvLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSYS 243

                        250       260
                 ....*....|....*....|....*..
gi 116174762 265 M--DKMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd15914  244 LdyDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

23-296

1.43e-75

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 232.75 E-value: 1.43e-75

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  23 KMVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFAL 102
Cdd:cd15432    1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 103 HLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPL 182
Cdd:cd15432   81 LGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 183 LKLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPT 261
Cdd:cd15432  161 LKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAvLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPS 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 116174762 262 TFSMD--KMVAVFYTIGTPFLNPIIYTLRNAEVKNAM 296
Cdd:cd15432  241 NSSHDrgKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

24-296

1.28e-74

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 230.12 E-value: 1.28e-74

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLGTVVGNTLIIMTIKF-SRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKK-NIISYNECMTQVFA 101
Cdd:cd15941    2 LFFLLFLLIYLLTVLGNLLILLTIGSdPHLHGLPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSgRTISFEGCVVQLYA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 102 LHLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQP 181
Cdd:cd15941   82 FHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 182 LLKLACMDTYMINLLLVSNSGAICSSSFVILIISY-FVILHSLRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPP 260
Cdd:cd15941  162 VLKLACADTTINELVILANIGIVAAGCFLLIVISYiYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPS 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 116174762 261 TTFSMDKMVAVFYTIGTPFLNPIIYTLRNAEVKNAM 296
Cdd:cd15941  242 SSQAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

23-296

2.12e-74

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 229.57 E-value: 2.12e-74

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  23 KMVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFAL 102
Cdd:cd15434    1 KILSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 103 HLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPL 182
Cdd:cd15434   81 LGLGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 183 LKLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPT 261
Cdd:cd15434  161 IKLACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAvLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKN 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 116174762 262 TFSMD--KMVAVFYTIGTPFLNPIIYTLRNAEVKNAM 296
Cdd:cd15434  241 SVSQDqgKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

22-299

8.36e-74

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 228.13 E-value: 8.36e-74

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  22 QKMVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFA 101
Cdd:cd15418    1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 102 LHLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQP 181
Cdd:cd15418   81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 182 LLKLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPP 260
Cdd:cd15418  161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAiLRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 116174762 261 T--TFSMDKMVAVFYTIGTPFLNPIIYTLRNAEVKNAMKKL 299
Cdd:cd15418  241 SshTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

24-296

5.07e-73

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 226.21 E-value: 5.07e-73

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALH 103
Cdd:cd15428    2 LLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLL 183
Cdd:cd15428   82 SFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 184 KLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARP--P 260
Cdd:cd15428  162 KLASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTvFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPksS 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 116174762 261 TTFSMDKMVAVFYTIGTPFLNPIIYTLRNAEVKNAM 296
Cdd:cd15428  242 TSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

24-289

9.21e-73

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 225.05 E-value: 9.21e-73

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALH 103
Cdd:cd15946    2 ILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLL 183
Cdd:cd15946   82 ALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 184 KLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTT 262
Cdd:cd15946  162 KLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAiLKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSN 241

                        250       260
                 ....*....|....*....|....*....
gi 116174762 263 FS--MDKMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd15946  242 YSpeRDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

24-296

1.20e-70

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 220.02 E-value: 1.20e-70

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALH 103
Cdd:cd15236    2 VFFALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLL 183
Cdd:cd15236   82 FFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 184 KLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTT 262
Cdd:cd15236  162 KLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATiLKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSN 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 116174762 263 FSMDK--MVAVFYTIGTPFLNPIIYTLRNAEVKNAM 296
Cdd:cd15236  242 NSSDKdiVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

24-296

8.53e-68

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 212.73 E-value: 8.53e-68

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALH 103
Cdd:cd15233    2 VLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLL 183
Cdd:cd15233   82 LLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 184 KLACMDTYMINLLLVSNSGAICSSSFVILIISY-FVILHSLRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTT 262
Cdd:cd15233  162 QLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYaHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSV 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 116174762 263 FS--MDKMVAVFYTIGTPFLNPIIYTLRNAEVKNAM 296
Cdd:cd15233  242 YSsdKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

23-296

1.12e-67

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 212.34 E-value: 1.12e-67

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  23 KMVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFAL 102
Cdd:cd15433    1 PVLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFIS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 103 HLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPL 182
Cdd:cd15433   81 LALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 183 LKLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPT 261
Cdd:cd15433  161 LKLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAvLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIH 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 116174762 262 TFSMD--KMVAVFYTIGTPFLNPIIYTLRNAEVKNAM 296
Cdd:cd15433  241 RYSQAhgKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

26-296

4.82e-58

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 187.88 E-value: 4.82e-58

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15223    4 SLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFIHFF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKL 185
Cdd:cd15223   84 TAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMALVSL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFF--GPCIFIYARPPTT 262
Cdd:cd15223  164 ACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAvLRLASGEARSKALNTCGSHLIVILFFYtaVLVSSLTYRFGKT 243

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 116174762 263 FSMD--KMVAVFYTIGTPFLNPIIYTLRNAEVKNAM 296
Cdd:cd15223  244 IPPDvhVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

27-292

3.19e-54

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 177.87 E-value: 3.19e-54

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFG 106
Cdd:cd15917    5 IPFCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 107 CMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKLA 186
Cdd:cd15917   85 AMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 187 CMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTFSM 265
Cdd:cd15917  165 CGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAvLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFGHHV 244

                        250       260       270
                 ....*....|....*....|....*....|.
gi 116174762 266 DKMV----AVFYTIGTPFLNPIIYTLRNAEV 292
Cdd:cd15917  245 PPHVhillANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

27-292

1.59e-50

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 168.36 E-value: 1.59e-50

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFG 106
Cdd:cd15950    5 IPFCSMYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHSFT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 107 CMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKLA 186
Cdd:cd15950   85 AVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 187 CMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIF-IYAR------ 258
Cdd:cd15950  165 CADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAvLGLSSKEARLKAFSTCGSHVCVILLFYIPGLLsIYTQrfgqgv 244

                        250       260       270
                 ....*....|....*....|....*....|....
gi 116174762 259 PPTTfsmDKMVAVFYTIGTPFLNPIIYTLRNAEV 292
Cdd:cd15950  245 PPHT---QVLLADLYLLVPPMLNPIIYGMRTKQI 275

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

29-292

1.93e-48

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 162.93 E-value: 1.93e-48

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  29 FLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFGCM 108
Cdd:cd15952    7 FCAVYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFTGM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 109 EIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKLACM 188
Cdd:cd15952   87 ESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLACA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 189 DtymINLLLVSNSGAICSSSF-VILI-ISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTFSM 265
Cdd:cd15952  167 S---IRINIIYGLFAISVLVLdVILIaLSYVLILRAvFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFLTHRFGHNI 243

                        250       260       270
                 ....*....|....*....|....*....|.
gi 116174762 266 DK----MVAVFYTIGTPFLNPIIYTLRNAEV 292
Cdd:cd15952  244 PRyihiLLANLYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

25-292

2.81e-46

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 157.28 E-value: 2.81e-46

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  25 VFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHL 104
Cdd:cd15222    3 ISIPFCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 105 FGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLK 184
Cdd:cd15222   83 FSFMESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 185 LACMDTYMINL----LLVSNSGaicsSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCI------ 253
Cdd:cd15222  163 LACSDTRVNSIyglfVVLSTMG----LDSLLILLSYVLILKTvLGIASREERLKALNTCVSHICAVLIFYVPMIglsmvh 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 116174762 254 -FIYARPPTTFSmdkMVAVFYTIGTPFLNPIIYTLRNAEV 292
Cdd:cd15222  239 rFGKHASPLVHV---LMANVYLLVPPVLNPIIYSVKTKQI 275

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

27-292

4.65e-44

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 151.67 E-value: 4.65e-44

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFG 106
Cdd:cd15221    5 IPFCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 107 CMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKLA 186
Cdd:cd15221   85 VTESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 187 CMDTyMINLLLVSNSGAICSSSFVILI-ISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIY-------A 257
Cdd:cd15221  165 CADI-TVNIWYGLTVALLTVGLDVVLIaVSYALILRAvFRLPSKDARLKALSTCGSHVCVILMFYTPAFFSFlthrfgrH 243

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 116174762 258 RPPTTFSmdkMVAVFYTIGTPFLNPIIYTLRNAEV 292
Cdd:cd15221  244 IPRHVHI---LLANLYVLVPPMLNPIVYGVKTKQI 275

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

27-289

2.31e-43

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 149.80 E-value: 2.31e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFG 106
Cdd:cd15951    5 IPFCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 107 CMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKLA 186
Cdd:cd15951   85 TMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 187 CMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTFSM 265
Cdd:cd15951  165 CADTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAvFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLTHRFGHNV 244

                        250       260
                 ....*....|....*....|....*...
gi 116174762 266 DKMVAVF----YTIGTPFLNPIIYTLRN 289
Cdd:cd15951  245 PPHVHILianvYLLVPPMLNPIIYGVRT 272

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

27-292

4.89e-41

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 143.56 E-value: 4.89e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFG 106
Cdd:cd15953    5 IPFCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 107 CMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKLA 186
Cdd:cd15953   85 IMESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 187 CMDTyminllLVSNSGAICSSSFVI-----LI-ISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIF--IYA 257
Cdd:cd15953  165 CGDT------TINRIYGLVVALLVVgldllLIaLSYALIIRAvLRLSSKKARQKALNTCTAHICVILMSYTPALFsfLTH 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 116174762 258 R-----PPttfSMDKMVAVFYTIGTPFLNPIIYTLRNAEV 292
Cdd:cd15953  239 RfgqgiAP---HIHIILANLYLLVPPMLNPIIYGVKTKEI 275

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

29-299

2.06e-39

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 139.56 E-value: 2.06e-39

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762   29 FLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFGCM 108
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  109 EIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKLACM 188
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  189 DTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYAR-------PP 260
Cdd:pfam13853 161 DIKVNNIYGLFVVTSTFGIDSLLIVLSYGLILRTvLGIASREGRLKALNTCGSHVCAVLAFYTPMIGLSMVhrfghnvPP 240

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 116174762  261 TtfsMDKMVAVFYTIGTPFLNPIIYTLRNAEVKNAMKKL 299
Cdd:pfam13853 241 L---LQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRM 276

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

8-293

7.66e-39

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 138.37 E-value: 7.66e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762   8 TKFILLGLTQDPLKQKMVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKK 87
Cdd:cd15949    2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  88 NIISYNECMTQVFALHLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFC 167
Cdd:cd15949   82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 168 GPNLIDHYCCDLQPLLKLACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHSLRN-HSAEGRKKALSTCTSHIIVVI 246
Cdd:cd15949  162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRlATSEARLKTFGTCVSHVCAIL 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 116174762 247 LFFGPCI-------FIYARPPTTFSmdkMVAVFYTIGTPFLNPIIYTLRNAEVK 293
Cdd:cd15949  242 AFYVPIAvsslihrFGQNVPPPTHI---LLANFYLLIPPMLNPIVYGVRTKQIQ 292

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

27-292

5.56e-38

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 135.76 E-value: 5.56e-38

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFG 106
Cdd:cd15956    5 LPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 107 CMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKLA 186
Cdd:cd15956   85 AMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 187 CMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYA----RPPT 261
Cdd:cd15956  165 CGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTvLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLmhrfGHSV 244

                        250       260       270
                 ....*....|....*....|....*....|.
gi 116174762 262 TFSMDKMVAVFYTIGTPFLNPIIYTLRNAEV 292
Cdd:cd15956  245 PSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

27-293

9.90e-36

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 130.02 E-value: 9.90e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFG 106
Cdd:cd15948    6 IPFCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFS 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 107 CMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKLA 186
Cdd:cd15948   86 IMESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 187 CMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYA----RPPT 261
Cdd:cd15948  166 CGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAvLSLASKEEQLKAFGTCGSHICAILVFYTPVVLSSTmhrfARHV 245

                        250       260       270
                 ....*....|....*....|....*....|..
gi 116174762 262 TFSMDKMVAVFYTIGTPFLNPIIYTLRNAEVK 293
Cdd:cd15948  246 APHVHILLANFYLLFPPMMNPIVYGVKTKQIR 277

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

27-292

2.21e-34

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 126.09 E-value: 2.21e-34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFG 106
Cdd:cd15954    5 IPFCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 107 CMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKLA 186
Cdd:cd15954   85 GMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDHMSVVKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 187 CMDTYMINLLLVSNSGAICSSSFVILIISYFVILHS-LRNHSAEGRKKALSTCTSHIIVVILFFGPCIFI-----YARPP 260
Cdd:cd15954  165 CANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAvVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTffahrFGGHH 244

                        250       260       270
                 ....*....|....*....|....*....|..
gi 116174762 261 TTFSMDKMVAVFYTIGTPFLNPIIYTLRNAEV 292
Cdd:cd15954  245 ITPHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

39-285

3.82e-30

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 114.32 E-value: 3.82e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762   39 GNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKN-IISYNECMTQVFALHLFGCMEIFVLILMA 117
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDwPFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  118 VDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNlidHYCCDLQPLLKLACMDTYMINLLL 197
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGN---VTVCFIDFPEDLSKPVSYTLLISV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  198 VsnsGAICssSFVILIISYFVILHSLRNHSAEG--------RKKALSTCTSHIIVVILFFGPCIFIYARPPTTFS----- 264
Cdd:pfam00001 158 L---GFLL--PLLVILVCYTLIIRTLRKSASKQkssertqrRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDcelsr 232

                         250       260
                  ....*....|....*....|....
gi 116174762  265 -MDKMVAVFYTIG--TPFLNPIIY 285
Cdd:pfam00001 233 lLDKALSVTLWLAyvNSCLNPIIY 256

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

27-292

4.30e-30

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 114.87 E-value: 4.30e-30

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFG 106
Cdd:cd15955    5 IPFCIMFLLAVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFIHTLQ 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 107 CMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWI-GSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPLLKL 185
Cdd:cd15955   85 AFESGILLAMALDRYVAICHPLRHSSILTPQVLLGIGVLVVVrAVVLIIPCPLLIKLRLHHFRSTVISHSYCEHMAVVKL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLLVSNSGAICSSSFVILIISYFVILHSL-RNHSAEGRKKALSTCTSHIIVVILFFGPCIFIYARPPTTFS 264
Cdd:cd15955  165 AADDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVfRLPQKEARLKAFNTCTAHIFVFLLFYTLAFFSFFAHRFGHH 244

                        250       260       270
                 ....*....|....*....|....*....|..
gi 116174762 265 MDKMV----AVFYTIGTPFLNPIIYTLRNAEV 292
Cdd:cd15955  245 VAPYVhillSNLYLLVPPVLNPIVYGVKTKQI 276

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

26-289

2.55e-23

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 96.59 E-value: 2.55e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd00637    2 AVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDLQPllkl 185
Cdd:cd00637   82 LLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTL---- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 acMDTYMINLLLVsnsgaICSSSFVILIISYFVILHSLRNHSAEGRKKALSTCTSH------------IIVVILFF---G 250
Cdd:cd00637  158 --SKAYTIFLFVL-----LFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRrrrrerkvtktlLIVVVVFLlcwL 230

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 116174762 251 P------CIFIYARPPTTFSMDKMVAVFYTIGTPFLNPIIYTLRN 289
Cdd:cd00637  231 PyfilllLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

27-296

2.31e-16

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 77.22 E-value: 2.31e-16

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFG 106
Cdd:cd14967    4 VFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCC 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 107 CMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVlaLRLPFCGPNLIDHYCCDLQPllkla 186
Cdd:cd14967   84 TASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLV--GWRDETQPSVVDCECEFTPN----- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 187 cmDTYMINLLLVSnsgaiCSSSFVILIISYFVILHSLRNHsaegrKKALSTctshIIVVILFFGPC-------IFIYARP 259
Cdd:cd14967  157 --KIYVLVSSVIS-----FFIPLLIMIVLYARIFRVARRE-----LKAAKT----LAIIVGAFLLCwlpffiiYLVSAFC 220

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 116174762 260 PTTFSMDKMVAVFYTIG--TPFLNPIIYTLRNAEVKNAM 296
Cdd:cd14967  221 PPDCVPPILYAVFFWLGylNSALNPIIYALFNRDFRRAF 259

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

24-296

5.34e-13

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 68.00 E-value: 5.34e-13

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFY-LGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFAL 102
Cdd:cd14969    1 YVLAVYLSLIgVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 103 HLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVcVILIILAWIGSFIHSTAqivlalrlPFCGPNLI----DHYCCD 178
Cdd:cd14969   81 TFLGLVSISTLAALAFERYLVIVRPLKAFRLSKRRA-LILIAFIWLYGLFWALP--------PLFGWSSYvpegGGTSCS 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 179 LQPLLKLACMDTYMINLLLVSNSGAIcsssfVILIISYFVILHSLRNHSAEGRKKALSTCTS-----------HIIVVIL 247
Cdd:cd14969  152 VDWYSKDPNSLSYIVSLFVFCFFLPL-----AIIIFCYYKIYRTLRKMSKRAARRKNSAITKrtkkaekkvakMVLVMIV 226

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 116174762 248 FFGPCIFIYArppttfsmdkMVAVFYTIGTPFL-------------------NPIIYTLRNAEVKNAM 296
Cdd:cd14969  227 AFLIAWTPYA----------VVSLYVSFGGESTippllatipalfaksstiyNPIIYVFMNKQFRRAL 284

7tmA_Melanopsin

cd15336

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...

26-156

5.52e-12

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320458 [Multi-domain] Cd Length: 290 Bit Score: 65.12 E-value: 5.52e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGtVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15336    5 SVILIIGITG-MLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALF 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTA 156
Cdd:cd15336   84 GITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLP 134

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

24-160

8.07e-12

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 64.18 E-value: 8.07e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLgTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFST-STAPRLIVD---------ALSKknIISYn 93
Cdd:cd15196    3 EIAVLATILVL-ALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALfNVLPQLIWDityrfyggdLLCR--LVKY- 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 116174762  94 ecmTQVFALHLfgcmEIFVLILMAVDRYVAICKPLRYpVIMSRQVCVILIILAWIGSFIHSTAQIVL 160
Cdd:cd15196   79 ---LQVVGMYA----SSYVLVATAIDRYIAICHPLSS-HRWTSRRVHLMVAIAWVLSLLLSIPQLFI 137

7tmA_5-HT7

cd15329

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...

25-150

1.11e-10

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320452 [Multi-domain] Cd Length: 260 Bit Score: 60.75 E-value: 1.11e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  25 VFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHL 104
Cdd:cd15329    3 IGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYWPFGEILCDVWISFDVL 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 116174762 105 FGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGS 150
Cdd:cd15329   83 LCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLS 128

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

27-152

3.90e-10

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 59.65 E-value: 3.90e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFG 106
Cdd:cd15083    5 IFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFG 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 116174762 107 CMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFI 152
Cdd:cd15083   85 IMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLL 130

7tmA_Opsin_Gq_invertebrates

cd15337

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...

37-154

1.72e-09

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320459 [Multi-domain] Cd Length: 292 Bit Score: 57.72 E-value: 1.72e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  37 VVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTA-PRLIVDALSKKNIISYNECMTQVFALHLFGCMEIFVLIL 115
Cdd:cd15337   15 VIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNGfPLKTISSFNKKWIWGKVACELYGFAGGIFGFMSITTLAA 94

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 116174762 116 MAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHS 154
Cdd:cd15337   95 ISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWS 133

7tmA_5-HT2

cd15052

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...

26-295

6.36e-09

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320180 [Multi-domain] Cd Length: 262 Bit Score: 55.78 E-value: 6.36e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFylGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAP-RLIVDALSKKNIISYNECMTQVFALHL 104
Cdd:cd15052    6 LLLLLVI--ATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLLWVTLDVL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 105 FGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPfcgPNLIDHYCCDLQpllk 184
Cdd:cd15052   84 FCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPVLGIIDT---TNVLNNGTCVLF---- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 185 lacMDTYMInlllvsnSGAICS--SSFVILIISYFVILHSLRNhsaegRKKALSTCTSHIIVVILFFGPCIFIYARPPTT 262
Cdd:cd15052  157 ---NPNFVI-------YGSIVAffIPLLIMVVTYALTIRLLSN-----EQKASKVLGIVFAVFVICWCPFFITNILTGLC 221

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 116174762 263 FS-----MDKMVAVFYTIG--TPFLNPIIYTLRNAEVKNA 295
Cdd:cd15052  222 EEcncriSPWLLSVFVWLGyvSSTINPIIYTIFNKTFRRA 261

7tmA_NTSR-like

cd14979

neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...

25-295

8.87e-09

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320110 [Multi-domain] Cd Length: 300 Bit Score: 55.44 E-value: 8.87e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  25 VFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNE-CMTQVFALH 103
Cdd:cd14979    3 VTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYPWAFGDGgCKLYYFLFE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIhstaqivLALRLPFCGPNLIDHYCCDLQPLL 183
Cdd:cd14979   83 ACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSIL-------CAIPILFLMGIQYLNGPLPGPVPD 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 184 KLACMDTYMINLLLVSNSGAICSSSFV---ILIISYFVI---LHSLRNHSAEGRKKALSTCTSHII------------VV 245
Cdd:cd14979  156 SAVCTLVVDRSTFKYVFQVSTFIFFVLpmfVISILYFRIgvkLRSMRNIKKGTRAQGTRNVELSLSqqarrqvvkmlgAV 235

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 116174762 246 ILFFGPC---------IFIYARPPTTFSMDKMVAVFYTIGTPF-----LNPIIYTLRNAEVKNA 295
Cdd:cd14979  236 VIAFFVCwlpfhaqrlMFSYASKEDTFLFDFYQYLYPISGILFylssaINPILYNLMSSRFRVA 299

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

27-160

2.46e-08

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 54.30 E-value: 2.46e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIV----------DALSKknIISYnecm 96
Cdd:cd14986    5 AVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTQIIweatgewvagDVLCR--IVKY---- 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 116174762  97 TQVFALHLfgcmEIFVLILMAVDRYVAICKPLRypVIMSRQVCVILIILAWIGSFIHSTAQIVL 160
Cdd:cd14986   79 LQVVGLFA----STYILVSMSLDRYQAIVKPMS--SLKPRKRARLMIVVAWVLSFLFSIPQLVI 136

7tmA_TAAR5

cd15318

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...

27-155

2.62e-08

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320441 [Multi-domain] Cd Length: 282 Bit Score: 54.10 E-value: 2.62e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGT---VVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALH 103
Cdd:cd15318    2 VIYLACAIGMliiVLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTVLPFSTIRSVESCWYFGDSFCRLHTCLDT 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHST 155
Cdd:cd15318   82 LFCLTSIFHLCFISIDRHCAICDPLLYPSKFTIRVACIFIAAGWLVPTVYTS 133

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

27-296

3.46e-08

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 53.45 E-value: 3.46e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFAD---SCFSTSTAprLIVDALSKKniISYNECMTQVFALH 103
Cdd:cd14972    3 VVAIVLGVFIVVENSLVLAAIIKNRRLHKPMYILIANLAAADllaGIAFVFTF--LSVLLVSLT--PSPATWLLRKGSLV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWigsfihsTAQIVLALrLPFCGPN---LIDHYCCDLQ 180
Cdd:cd14972   79 LSLLASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVW-------VWSVLLAL-LPVLGWNcvlCDQESCSPLG 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 181 PLLKlacmDTYMInLLLVSNSGAicsssFVILIISYFVILHSLRNHSAEGRKKALSTCTSH-----------IIVVILFF 249
Cdd:cd14972  151 PGLP----KSYLV-LILVFFFIA-----LVIIVFLYVRIFWCLWRHANAIAARQEAAVPAQpstsrklaktvVIVLGVFL 220

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 116174762 250 ---GP-CIFIYARPPTTFSMDKMVAVFYTIGTPFLN----PIIYTLRNAEVKNAM 296
Cdd:cd14972  221 vcwLPlLILLVLDVLCPSVCDIQAVFYYFLVLALLNsainPIIYAFRLKEMRRAV 275

7tmA_TAAR5-like

cd15317

trace amine-associated receptor 5 and similar receptors, member of the class A family of ...

27-158

3.78e-08

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320440 [Multi-domain] Cd Length: 290 Bit Score: 53.61 E-value: 3.78e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLG---TVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALH 103
Cdd:cd15317    2 IIYIVLVLAmliTVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLDL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQI 158
Cdd:cd15317   82 LLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGLI 136

7tmA_Octopamine_R

cd15063

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...

26-152

6.51e-08

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.

Pssm-ID: 320191 [Multi-domain] Cd Length: 266 Bit Score: 52.88 E-value: 6.51e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECmTQVFALHLF 105
Cdd:cd15063    4 LLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWC-QIWLAVDVW 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 116174762 106 GCM-EIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFI 152
Cdd:cd15063   83 MCTaSILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFV 130

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

24-256

9.01e-08

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 52.45 E-value: 9.01e-08

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALH 103
Cdd:cd15012    1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNliDHYCcdlqplL 183
Cdd:cd15012   81 LSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQ--DGQE------E 152

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 116174762 184 KLACMDTYMINLLLVSNSGAIC--SSSFVILIISYFVILHSL-RNHSAEGRKKALSTctshIIVVILFFGPCIFIY 256
Cdd:cd15012  153 EICVLDREMFNSKLYDTINFIVwyLIPLLIMTVLYSKISIVLwKSSSIEARRKVVRL----LVAVVVSFALCNLPY 224

7tmA_Opsin5_neuropsin

cd15074

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...

27-156

1.15e-07

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.

Pssm-ID: 320202 [Multi-domain] Cd Length: 284 Bit Score: 52.28 E-value: 1.15e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFG 106
Cdd:cd15074    5 IYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFG 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 116174762 107 CMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCvILIILAWIGSFIHSTA 156
Cdd:cd15074   85 CCSINTLTAISIYRYLKICHPPYGPKLSRRHVC-IVIVAIWLYALFWAVA 133

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

26-152

1.22e-07

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 51.87 E-value: 1.22e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKniISYNECMTQVFALHLF 105
Cdd:cd14968    4 IVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIPLAILISLGLP--TNFHGCLFMACLVLVL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFI 152
Cdd:cd14968   82 TQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFL 128

7tmA_mAChR_DM1-like

cd15301

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...

24-152

1.26e-07

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320428 [Multi-domain] Cd Length: 270 Bit Score: 51.75 E-value: 1.26e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALH 103
Cdd:cd15301    2 LIVIVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDY 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFI 152
Cdd:cd15301   82 LASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLL 130

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

110-165

1.66e-07

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 51.79 E-value: 1.66e-07

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 116174762 110 IFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLP 165
Cdd:cd15055   88 IFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLYDNLNQP 143

7tmA_Parapinopsin

cd15075

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...

27-293

1.96e-07

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.

Pssm-ID: 320203 [Multi-domain] Cd Length: 279 Bit Score: 51.32 E-value: 1.96e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGN-TLIIMTIKFsRTLGSPMYFFLFYLSFAD-SCFSTSTAPRLIVDALSKKNIISYNeCMTQVFALHL 104
Cdd:cd15075    5 IIMAVFSIASVVLNaTVIIVTLRH-KQLRQPLNYALVNLAVADlGTTVFGGLLSVVTNAVGYFNLGRVG-CVLEGFAVAF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 105 FGCMEIFVLILMAVDRYVAICKPLRyPVIMSRQVCVILIILAWIGSFIHSTAQIV------LALRLPFCGPnliDHYCCD 178
Cdd:cd15075   83 FGIAALCTVAVIAVDRLFVVCKPLG-TLTFQTRHALAGIASSWLWSLIWNTPPLFgwgsyqLEGVMTSCAP---DWYSRD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 179 LQPLLKLACMDTYMINLllvsnsgaicssSFVILIISYFVILHSLRNHSAEG------RKKALSTCTSHIIVVILFFGPC 252
Cdd:cd15075  159 PVNVSYILCYFSFCFAI------------PFAIILVSYGYLLWTLRQVAKLGvaeggsTAKAEVQVARMVVVMVMAFLLC 226

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 116174762 253 IFIYArpptTFSMD-------------KMVAVFYTIGTPFLNPIIYTLRNAEVK 293
Cdd:cd15075  227 WLPYA----AFALTvvskpdvyinpliATVPMYLAKSSTVYNPIIYIFMNKQFR 276

7tmA_TACR

cd15390

neurokinin receptors (or tachykinin receptors), member of the class A family of ...

25-161

2.10e-07

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.

Pssm-ID: 320512 [Multi-domain] Cd Length: 289 Bit Score: 51.53 E-value: 2.10e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  25 VFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHL 104
Cdd:cd15390    3 WSIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAIT 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 116174762 105 FGCMEIFVLILMAVDRYVAICKPLRYPviMSRQVCVILIILAWIGSFIHSTAQIVLA 161
Cdd:cd15390   83 TVAASVFTLMAISIDRYIAIVHPLRPR--LSRRTTKIAIAVIWLASFLLALPQLLYS 137

7tmA_CCKR-like

cd14993

cholecystokinin receptors and related proteins, member of the class A family of ...

24-152

3.10e-07

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.

Pssm-ID: 320124 [Multi-domain] Cd Length: 296 Bit Score: 50.68 E-value: 3.10e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIF--LVFYLGtVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFA 101
Cdd:cd14993    1 IVLIVLyvVVFLLA-LVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPLTLLENVYRPWVFGEVLCKAVPYL 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 116174762 102 LHLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFI 152
Cdd:cd14993   80 QGVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAII 130

7tmA_Histamine_H2R

cd15051

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...

27-154

3.29e-07

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320179 [Multi-domain] Cd Length: 287 Bit Score: 50.79 E-value: 3.29e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKK--------NI-ISYNECMT 97
Cdd:cd15051    5 VVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLGLLVLPFSAIYELRGEwplgpvfcNIyISLDVMLC 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 116174762  98 QVFALHLFgcmeifvliLMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHS 154
Cdd:cd15051   85 TASILNLF---------AISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVS 132

7tmA_alpha1D_AR

cd15327

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...

25-154

3.68e-07

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320450 [Multi-domain] Cd Length: 261 Bit Score: 50.30 E-value: 3.68e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  25 VFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPrlIVDALSKKNIISYNECMTQVFALHL 104
Cdd:cd15327    3 VGVFLAIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLP--FSATLEVLGFWAFGRVFCDIWAAVD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 116174762 105 FGC--MEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHS 154
Cdd:cd15327   81 VLCctASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVIS 132

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

27-154

4.23e-07

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 50.32 E-value: 4.23e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIkFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQV-----FA 101
Cdd:cd14978    5 YVLPVICIFGIIGNILNLVVL-TRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFlpyiyPL 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 116174762 102 LHLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHS 154
Cdd:cd14978   84 ANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLN 136

7tmA_alpha1A_AR

cd15325

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

27-154

6.36e-07

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320448 [Multi-domain] Cd Length: 261 Bit Score: 49.89 E-value: 6.36e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFG 106
Cdd:cd15325    5 VILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCC 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 116174762 107 CMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHS 154
Cdd:cd15325   85 TASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVIS 132

7tmA_mAChR_M2

cd15297

muscarinic acetylcholine receptor subtype M2, member of the class A family of ...

25-152

7.30e-07

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320424 [Multi-domain] Cd Length: 262 Bit Score: 49.58 E-value: 7.30e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  25 VFIIFL--VFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFAL 102
Cdd:cd15297    1 VFIVLVagSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 116174762 103 HLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFI 152
Cdd:cd15297   81 YVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFI 130

7tmA_MCR

cd15103

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...

28-159

8.44e-07

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320231 [Multi-domain] Cd Length: 270 Bit Score: 49.41 E-value: 8.44e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  28 IFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQ--------V 99
Cdd:cd15103    6 VFLTLGIVSLLENILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSNALETIVIILLNNGYLVPRDSFEQhidnvidsM 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 100 FALHLFGcmEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIV 159
Cdd:cd15103   86 ICSSLLA--SICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGILFII 143

7tmA_GnRHR-like

cd15195

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...

27-294

1.78e-06

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.

Pssm-ID: 320323 [Multi-domain] Cd Length: 293 Bit Score: 48.55 E-value: 1.78e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNEC----MTQVFAL 102
Cdd:cd15195    5 LVTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCrvmmFLKQFGM 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 103 HLfgcmEIFVLILMAVDRYVAICKPLRypVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIDHYCCDL--- 179
Cdd:cd15195   85 YL----SSFMLVVIALDRVFAILSPLS--ANQARKRVKIMLTVAWVLSALCSIPQSFIFSVLRKMPEQPGFHQCVDFgsa 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 180 --QPLLKLACMDTYMINLLLVSNSGAICSSSFVILII--------SYFVILHSLRNHSAE-GRKKALSTCTSHIIVVILF 248
Cdd:cd15195  159 ptKKQERLYYFFTMILSFVIPLIITVTCYLLILFEISkmakrardTPISNRRRSRTNSLErARMRTLRMTALIVLTFIVC 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 116174762 249 FGP--CIFIY--------ARPPttfsmDKMVAVFYTIGT--PFLNPIIYTLRNAEVKN 294
Cdd:cd15195  239 WGPyyVLGLWywfdkesiKNLP-----PALSHIMFLLGYlnPCLHPIIYGVFMKEIRN 291

7tmA_MC1R

cd15351

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...

28-159

1.89e-06

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320473 [Multi-domain] Cd Length: 271 Bit Score: 48.25 E-value: 1.89e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  28 IFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQvfalHLFGC 107
Cdd:cd15351    6 LFLFLGLVSLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIETLFMLLLEHGVLVCRAPMLQ----HMDNV 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116174762 108 MEIFV----------LILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIV 159
Cdd:cd15351   82 IDTMIcssvvsslsfLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSSTLFIV 143

7tmA_MC3R

cd15352

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...

28-148

1.98e-06

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320474 [Multi-domain] Cd Length: 272 Bit Score: 48.35 E-value: 1.98e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  28 IFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFAlHLFGC 107
Cdd:cd15352    6 VFLTLGIVSLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSNSLETIMIAVLNSGYLVISDQFIQHMD-NVFDS 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 116174762 108 M-------EIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWI 148
Cdd:cd15352   85 MicislvaSICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWV 132

7tmA_V1aR

cd15385

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

23-157

2.13e-06

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320507 [Multi-domain] Cd Length: 301 Bit Score: 48.28 E-value: 2.13e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  23 KMVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFST-STAPRLIVDALSKKNIISYneCMTQVFA 101
Cdd:cd15385    1 KLEIAVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFfQVLPQLCWDITYRFYGPDF--LCRIVKH 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 116174762 102 LHLFGCM-EIFVLILMAVDRYVAICKPLRyPVIMSRQVCVILIILAWIGSFIHSTAQ 157
Cdd:cd15385   79 LQVLGMFaSTYMLVMMTADRYIAICHPLK-TLQQPTKRSYLMIGSAWALSFILSTPQ 134

7tmA_5-HT2B

cd15306

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...

27-298

2.49e-06

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341347 [Multi-domain] Cd Length: 277 Bit Score: 47.90 E-value: 2.49e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAP-RLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15306    5 LLILMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPiALLTILFEAMWPLPLVLCPIWLFLDVLF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSfihstaqIVLALRLPFCG----PNLIDHYCCDLQP 181
Cdd:cd15306   85 STASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLIS-------IGIAIPVPIKGietdVDNPNNITCVLTK 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 182 llklacmDTYmiNLLLVSNSGAICSSSFVILIISYFVILHSLRNHSAEGRKKALSTCTSHIIVVILFFGPCIF-----IY 256
Cdd:cd15306  158 -------ERF--GDFILFGSLAAFFTPLAIMIVTYFLTIHALRKQTITNEQRASKVLGIVFFLFLLMWCPFFItnitsVL 228

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 116174762 257 ARPPTTFSMDKMVAVFYTIG--TPFLNPIIYTLRNAEVKNAMKK 298
Cdd:cd15306  229 CDSCNQTTLQMLMEIFVWIGyvSSGVNPLVYTLFNKTFRDAFGR 272

7tmA_5-HT2_insect-like

cd15307

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...

27-154

2.56e-06

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320433 [Multi-domain] Cd Length: 279 Bit Score: 48.02 E-value: 2.56e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFG 106
Cdd:cd15307    5 LLALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWICLDVLFC 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 116174762 107 CMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHS 154
Cdd:cd15307   85 TASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMS 132

7tmA_SREB-like

cd15005

super conserved receptor expressed in brain and related proteins, member of the class A family ...

36-147

3.16e-06

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320134 [Multi-domain] Cd Length: 329 Bit Score: 47.84 E-value: 3.16e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  36 TVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKN-IISYNECMTQVFALHLFGCMEIFVLI 114
Cdd:cd15005   14 SLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPFVMASVRHGSGwIYGALSCKVIAFLAVLFCFHSAFTLF 93

                         90       100       110
                 ....*....|....*....|....*....|...
gi 116174762 115 LMAVDRYVAICKPLRYPVIMSRQVCVILIILAW 147
Cdd:cd15005   94 CIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAW 126

7tmA_alpha1_AR

cd15062

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...

25-154

3.62e-06

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320190 [Multi-domain] Cd Length: 261 Bit Score: 47.48 E-value: 3.62e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  25 VFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPrlIVDALSKKNIISYNECMTQVFALHL 104
Cdd:cd15062    3 VGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLP--FSATLEVLGYWAFGRIFCDVWAAVD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 116174762 105 FGC--MEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHS 154
Cdd:cd15062   81 VLCctASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVIS 132

7tmA_alpha1B_AR

cd15326

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

32-154

5.11e-06

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320449 [Multi-domain] Cd Length: 261 Bit Score: 46.81 E-value: 5.11e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  32 FYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPrlIVDALSKKNIISYNECMTQVFALHLFGC--ME 109
Cdd:cd15326   10 FILFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLP--FSATLEILGYWVFGRIFCDIWAAVDVLCctAS 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 116174762 110 IFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHS 154
Cdd:cd15326   88 ILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVIS 132

7tmA_tyramine_R-like

cd15061

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

27-159

5.16e-06

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320189 [Multi-domain] Cd Length: 256 Bit Score: 46.97 E-value: 5.16e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVfALHLFG 106
Cdd:cd15061    4 SFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWI-SLDVLL 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 116174762 107 CM-EIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIV 159
Cdd:cd15061   83 CTaSILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLV 136

7tmA_MC4R

cd15353

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...

28-147

5.36e-06

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320475 [Multi-domain] Cd Length: 269 Bit Score: 46.83 E-value: 5.36e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  28 IFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKN-------IISYNECMTQVF 100
Cdd:cd15353    6 VFVTLGIVSLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETVVITLLNGNdtdaqsfTVNIDNVIDSVI 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 116174762 101 ALHLFGcmEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAW 147
Cdd:cd15353   86 CSSLLA--SICSLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIW 130

7tmA_GPR101

cd15215

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...

23-155

6.01e-06

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320343 [Multi-domain] Cd Length: 261 Bit Score: 46.76 E-value: 6.01e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  23 KMVFIIFLVfyLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFAL 102
Cdd:cd15215    2 RSVLIVIFL--CASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLM 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 116174762 103 HLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHST 155
Cdd:cd15215   80 HLFAFAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQST 132

7tmA_GPR19

cd15008

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...

27-148

6.08e-06

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320137 [Multi-domain] Cd Length: 275 Bit Score: 46.75 E-value: 6.08e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFG 106
Cdd:cd15008    4 LVFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQYLTP 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 116174762 107 CMEIFVLILMAVDRYVAICKPLRYPVimSRQVCVILIILAWI 148
Cdd:cd15008   84 GVQIYVLLSICVDRFYTIVYPLSFKV--SREKAKKMIAASWL 123

7tmA_GnRHR_invertebrate

cd15384

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...

27-160

6.09e-06

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.

Pssm-ID: 320506 [Multi-domain] Cd Length: 293 Bit Score: 47.05 E-value: 6.09e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNEC----MTQVFAL 102
Cdd:cd15384    5 VVLAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMCklvkYLQVFGL 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 116174762 103 HLfgcmEIFVLILMAVDRYVAICKPLRYPVIMSRqvCVILIILAWIGSFIHSTAQIVL 160
Cdd:cd15384   85 YL----STYITVLISLDRCVAILYPMKRNQAPER--VRRMVTVAWILSPIFSIPQAVI 136

7tmA_Beta_AR

cd15058

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...

24-160

7.61e-06

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320186 [Multi-domain] Cd Length: 305 Bit Score: 46.68 E-value: 7.61e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLvfylgTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNEC--MTQVFA 101
Cdd:cd15058    7 LALIILA-----IVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCelWTSVDV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 116174762 102 LHLFGCMEifVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVL 160
Cdd:cd15058   82 LCVTASIE--TLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSFVPIMN 138

7tmA_Adenosine_R_A2B

cd15069

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...

30-151

8.92e-06

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320197 [Multi-domain] Cd Length: 294 Bit Score: 46.46 E-value: 8.92e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  30 LVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKniISYNECMTQVFALHLFGCME 109
Cdd:cd15069    8 LIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFC--TDFHSCLFLACFVLVLTQSS 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 116174762 110 IFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSF 151
Cdd:cd15069   86 IFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAF 127

7tmA_Peropsin

cd15073

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...

37-296

9.75e-06

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.

Pssm-ID: 320201 [Multi-domain] Cd Length: 280 Bit Score: 46.27 E-value: 9.75e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  37 VVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFGCMEIFVLILM 116
Cdd:cd15073   15 TISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLLTVV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 117 AVDRYVAICKPLRYPViMSRQVCVILIILAWIGSFIHSTAqivlalrlpfcgpnlidhyccdlqPLLKLACMDTyminll 196
Cdd:cd15073   95 AVDRYLTICRPDLGRK-MTTNTYTVMILLAWTNAFFWAAM------------------------PLVGWASYAL------ 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 197 lvSNSGAICS-------SSFVILIISYF---------VILHSLRNHSAEGRKKALSTCTSHI---------------IVV 245
Cdd:cd15073  144 --DPTGATCTinwrkndSSFVSYTMSVIvvnfivplaVMFYCYYNVSRFVKKVLASDCLESVnidwtdqndvtkmsvIMI 221

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 116174762 246 ILFFGP-------CIFI-YARPPTTFSMDKMVAVFYTIGTPFLNPIIYTLRNAEVKNAM 296
Cdd:cd15073  222 VMFLVAwspysivCLWAsFGEPKKIPPWMAIIPPLFAKSSTFYNPCIYVIANKKFRRAI 280

7tmA_Histamine_H1R

cd15050

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...

34-151

9.88e-06

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320178 [Multi-domain] Cd Length: 263 Bit Score: 46.27 E-value: 9.88e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  34 LGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFGCMEIFVL 113
Cdd:cd15050   12 LITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVGAVVMPLNIVYLLESKWILGRPVCLFWLSMDYVASTASIFSL 91

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 116174762 114 ILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSF 151
Cdd:cd15050   92 FILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSF 129

7tmA_NPSR

cd15197

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...

26-237

1.08e-05

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).

Pssm-ID: 320325 [Multi-domain] Cd Length: 294 Bit Score: 46.26 E-value: 1.08e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFS-TSTAPRLIVDalskkniisynecMTQVFALHL 104
Cdd:cd15197    4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVGlINVLTDIIWR-------------ITVEWRAGD 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 105 FGCMEI------------FVLILMAVDRYVAICKPLRypVIMSRQVCVILIILAWIGSFIHSTAQIVLALR------LPF 166
Cdd:cd15197   71 FACKVIrylqvvvtyastYVLVALSIDRYDAICHPMN--FSQSGRQARVLICVAWILSALFSIPMLIIFEKtglsngEVQ 148

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 116174762 167 CGPNLIDHYccDLQPLLKLACMDTYMINLLLVSnsgaICSSSFVILIISYFVILHSLRNHSAEGRKKALST 237
Cdd:cd15197  149 CWILWPEPW--YWKVYMTIVAFLVFFIPATIIS----ICYIIIVRTIWKKSKIQVTINKAGLHDGSSRRSS 213

7tmA_LWS_opsin

cd15081

long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...

25-296

1.13e-05

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320209 [Multi-domain] Cd Length: 292 Bit Score: 46.05 E-value: 1.13e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  25 VFIIFLVFylGTVVGNTLIIM-TIKFSRtLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALH 103
Cdd:cd15081   17 VWMIFVVF--ASVFTNGLVLVaTLKFKK-LRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFILGHPMCVLEGFTVS 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPLRyPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRL------PFCGPnliDHYCC 177
Cdd:cd15081   94 VCGITGLWSLTIISWERWVVVCKPFG-NIKFDGKLAIVGIIFSWVWSAVWCAPPIFGWSRYwphglkTSCGP---DVFSG 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 178 DLQPLLKlacmdTYMINLLLVSnsgaiCSSSFVILIISYFVILHSLR-----NHSAEGRKKALSTCTSHIIVVILFFGPC 252
Cdd:cd15081  170 SSDPGVQ-----SYMIVLMITC-----CIIPLAIIILCYLQVWLAIRavaqqQKESESTQKAEKEVSRMVVVMIFAYCFC 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 116174762 253 --------IFIYARPPTTFS--MDKMVAVFYTIGTPFlNPIIYTLRNAEVKNAM 296
Cdd:cd15081  240 wgpytffaCFAAANPGYAFHplAAALPAYFAKSATIY-NPIIYVFMNRQFRNCI 292

7tmA_NPYR-like

cd15203

neuropeptide Y receptors and related proteins, member of the class A family of ...

24-152

1.19e-05

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.

Pssm-ID: 320331 [Multi-domain] Cd Length: 293 Bit Score: 46.06 E-value: 1.19e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLGtVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIisYNECMTQVFALh 103
Cdd:cd15203    3 LILLYGLIIVLG-VVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLCLVSLPFTLIYTLTKNWP--FGSILCKLVPS- 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 116174762 104 LFG---CMEIFVLILMAVDRYVAICKPLRYPviMSRQVCVILIILAWIGSFI 152
Cdd:cd15203   79 LQGvsiFVSTLTLTAIAIDRYQLIVYPTRPR--MSKRHALLIIALIWILSLL 128

7tmA_alpha2_AR

cd15059

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...

24-154

1.34e-05

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320187 [Multi-domain] Cd Length: 261 Bit Score: 45.80 E-value: 1.34e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLvfylgTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALskKNIISYNECMTQVF-AL 102
Cdd:cd15059    7 VSVVILL-----IIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNEL--MGYWYFGSVWCEIWlAL 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 116174762 103 HLFGCM-EIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHS 154
Cdd:cd15059   80 DVLFCTaSIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVIS 132

7tmA_Opioid_R-like

cd14970

opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...

27-285

1.36e-05

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.

Pssm-ID: 320101 [Multi-domain] Cd Length: 282 Bit Score: 45.75 E-value: 1.36e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLII-MTIKFSRtLGSPMYFFLFYLSFADSCFsTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd14970    5 AVYSVVCVVGLTGNSLVIyVILRYSK-MKTVTNIYILNLAVADELF-LLGLPFLATSYLLGYWPFGEVMCKIVLSVDAYN 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGpnliDHYCCDLQpllkL 185
Cdd:cd14970   83 MFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQEEG----GTISCNLQ----W 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLlvsnsgAICSSSF------VILIISYFVILHSLR------NHSAEGRKKALSTCTSHIIVVILFFGPC- 252
Cdd:cd14970  155 PDPPDYWGRVF------TIYTFVLgfavplLVITVCYSLIIRRLRssrnlsTSGAREKRRARRKVTRLVLVVVAVFVVCw 228

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 116174762 253 ----IFIYARPPTTFSMDKM-VAVFYTIGT-----PFLNPIIY 285
Cdd:cd14970  229 lpfhVFQIVRLLIDPPETLTvVGVFLFCIAlsyanSCLNPILY 271

7tmA_5-HT1_5_7

cd15064

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...

24-156

1.38e-05

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320192 [Multi-domain] Cd Length: 258 Bit Score: 45.78 E-value: 1.38e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFY-LGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECmtQVF-A 101
Cdd:cd15064    1 VLISVLLSLIiLATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLC--DIWiS 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 116174762 102 LHLFGCM-EIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTA 156
Cdd:cd15064   79 LDVTCCTaSILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLP 134

7tmA_Ap5-HTB1-like

cd15065

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...

27-160

1.39e-05

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.

Pssm-ID: 320193 [Multi-domain] Cd Length: 300 Bit Score: 45.80 E-value: 1.39e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFG 106
Cdd:cd15065    4 IFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWISFDVMCS 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 116174762 107 CMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVL 160
Cdd:cd15065   84 TASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLPIHL 137

7tmA_TAAR2_3_4

cd15312

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...

26-154

1.71e-05

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320437 [Multi-domain] Cd Length: 289 Bit Score: 45.42 E-value: 1.71e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15312    4 YLFMAGAILLTVFGNLMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLDMML 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHS 154
Cdd:cd15312   84 STTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFA 132

7tmA_photoreceptors_insect

cd15079

insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...

27-156

2.66e-05

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320207 [Multi-domain] Cd Length: 292 Bit Score: 44.87 E-value: 2.66e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFsTSTAPRLIVDALSKKNIISYNECmtQVFAL--HL 104
Cdd:cd15079    5 FIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLM-MIKMPIFIYNSFYEGWALGPLGC--QIYAFlgSL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 116174762 105 FGCMEIFVLILMAVDRYVAICKPLRyPVIMSRQVCVILIILAWIGSFIHSTA 156
Cdd:cd15079   82 SGIGSIWTNAAIAYDRYNVIVKPLN-GNPLTRGKALLLILFIWLYALPWALL 132

7tmA_Dop1R2-like

cd15067

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...

27-159

2.77e-05

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.

Pssm-ID: 320195 [Multi-domain] Cd Length: 262 Bit Score: 44.65 E-value: 2.77e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIIsYNECMTQVFalHLFG 106
Cdd:cd15067    4 VVLSLFCLVTVAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPFSILHEMTGGYWL-FGRDWCDVW--HSFD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 116174762 107 CM----EIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIV 159
Cdd:cd15067   81 VLastaSILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPAIA 137

7tmA_Adenosine_R_A3

cd15070

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...

34-152

2.87e-05

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.

Pssm-ID: 320198 [Multi-domain] Cd Length: 280 Bit Score: 44.77 E-value: 2.87e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  34 LGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVdaLSKKNIISYNECMTQVFALHLFGCMEIFVL 113
Cdd:cd15070   12 LCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIPLAIV--VSLGVTIHFYSCLFMSCLLVVFTHASIMSL 89

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 116174762 114 ILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFI 152
Cdd:cd15070   90 LAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFL 128

7tmA_mAChR_M4

cd15298

muscarinic acetylcholine receptor subtype M4, member of the class A family of ...

34-152

3.45e-05

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341344 [Multi-domain] Cd Length: 262 Bit Score: 44.63 E-value: 3.45e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  34 LGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFGCMEIFVL 113
Cdd:cd15298   12 LVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNL 91

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 116174762 114 ILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFI 152
Cdd:cd15298   92 LIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFV 130

7tmA_GPR161

cd15214

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...

26-152

3.76e-05

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320342 [Multi-domain] Cd Length: 261 Bit Score: 44.54 E-value: 3.76e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15214    3 SIAIIIIAILICLGNLVIVVTLYKKSYLLTLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLI 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFI 152
Cdd:cd15214   83 SSASMLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWLHSLI 129

7tmA_D1-like_dopamine_R

cd15057

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...

27-154

4.08e-05

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320185 [Multi-domain] Cd Length: 299 Bit Score: 44.34 E-value: 4.08e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMY-FFLFYLSFADSCFSTstaprLIVDALSKKNIISY----NECMTQVFA 101
Cdd:cd15057    5 CILYLLVLLTLLGNALVIAAVLRFRHLRSKVTnYFIVSLAVSDLLVAI-----LVMPWAAVNEVAGYwpfgSFCDVWVSF 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 116174762 102 LHLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHS 154
Cdd:cd15057   80 DIMCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALIS 132

7tmA_CCK-BR

cd15979

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...

27-170

5.04e-05

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320645 [Multi-domain] Cd Length: 275 Bit Score: 44.03 E-value: 5.04e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFG 106
Cdd:cd15979    5 LLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLMGVSV 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 116174762 107 CMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPN 170
Cdd:cd15979   85 SVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPVPVGD 148

7tmA_MC2R_ACTH_R

cd15350

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...

28-147

5.20e-05

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320472 [Multi-domain] Cd Length: 270 Bit Score: 44.00 E-value: 5.20e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  28 IFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYN--------ECMTQV 99
Cdd:cd15350    6 VFFTIAAVGLLENLLVLVAVIKNKNLHSPMYFFICSLAVSDMLGSLYKTLENILIILADMGYLNRRgpfetkldDIMDSL 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 116174762 100 FALHLFGcmEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAW 147
Cdd:cd15350   86 FCLSLLG--SIFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIW 131

7tmA_TAAR6_8_9

cd15316

trace amine-associated receptors 6, 8, and 9, member of the class A family of ...

27-156

5.22e-05

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320439 [Multi-domain] Cd Length: 290 Bit Score: 44.08 E-value: 5.22e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLG---TVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALH 103
Cdd:cd15316    2 ILYIVLGFGavlAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCDV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTA 156
Cdd:cd15316   82 SFCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYSFS 134

7tmA_leucokinin-like

cd15393

leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...

37-248

5.23e-05

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.

Pssm-ID: 320515 [Multi-domain] Cd Length: 288 Bit Score: 43.94 E-value: 5.23e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  37 VVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFGCMEIFVLILM 116
Cdd:cd15393   15 VVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSVNVSVFTLTVI 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 117 AVDRYVAICKPLRypVIMSRQVCVILIILAWIGSFIHSTAqIVLALRLPFcgpnLIDhyccDLQPLLKLACMDTYMIN-L 195
Cdd:cd15393   95 AVDRYRAVIHPLK--ARCSKKSAKIIILIIWILALLVALP-VALALRVEE----LTD----KTNNGVKPFCLPVGPSDdW 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116174762 196 LLVSNSGAICSSSFVILII---SYFVILHSLRNHSAEG-------------RKKALSTCtshIIVVILF 248
Cdd:cd15393  164 WKIYNLYLVCVQYFVPLVIicyAYTRIAVKIWGTKAPGnaqdvrddeilknKKKVIKML---IIVVALF 229

7tmA_CCK_R

cd15206

cholecystokinin receptors, member of the class A family of seven-transmembrane G ...

31-169

5.73e-05

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320334 [Multi-domain] Cd Length: 269 Bit Score: 43.92 E-value: 5.73e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  31 VFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFGCMEI 110
Cdd:cd15206    9 VIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLAVFCMPFTLVGQLLRNFIFGEVMCKLIPYFQAVSVSVST 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 116174762 111 FVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGP 169
Cdd:cd15206   89 FTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRP 147

7tmA_OT_R

cd15387

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...

25-158

6.96e-05

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320509 [Multi-domain] Cd Length: 297 Bit Score: 43.65 E-value: 6.96e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  25 VFIIFLVFYLGtVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFST-STAPRLIVDALSK-------KNIISYNEcM 96
Cdd:cd15387    4 VTVLALILFLA-LTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVfQVLPQLIWDITFRfygpdflCRLVKYLQ-V 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116174762  97 TQVFAlhlfgcmEIFVLILMAVDRYVAICKPLRYpviMSRQVCVILIILAWIGSFIHSTAQI 158
Cdd:cd15387   82 VGMFA-------STYMLLLMSIDRCLAICQPLRS---LHRRSDRVYVLFSWLLSLVFSIPQV 133

7tmA_GPR119_R_insulinotropic_receptor

cd15104

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...

27-152

7.62e-05

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320232 [Multi-domain] Cd Length: 283 Bit Score: 43.52 E-value: 7.62e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTI-KFSRTLGSPMYFFLFYLSFADSCFSTStAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15104    4 VILAVLSPLIITGNLLVIVALlKLIRKKDTKSNCFLLNLAIADFLVGLA-IPGLATDELLSDGENTQKVLCLLRMCFVIT 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 116174762 106 GC-MEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFI 152
Cdd:cd15104   83 SCaASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGL 130

7tmA_mAChR

cd15049

muscarinic acetylcholine receptor subfamily, member of the class A family of ...

36-152

7.89e-05

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341322 [Multi-domain] Cd Length: 262 Bit Score: 43.46 E-value: 7.89e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  36 TVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFGCMEIFVLIL 115
Cdd:cd15049   14 TVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIGLVSMNLYTVYLVMGYWPLGPLLCDLWLALDYVASNASVMNLLL 93

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 116174762 116 MAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFI 152
Cdd:cd15049   94 ISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFV 130

7tmA_AKHR

cd15382

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...

24-160

9.76e-05

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.

Pssm-ID: 320504 [Multi-domain] Cd Length: 298 Bit Score: 43.07 E-value: 9.76e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLGTVVGNTLIIMTIKFSRTLG-SPMYFFLFYLSFADSCFSTSTAPRLIV----------DALSKknIISY 92
Cdd:cd15382    2 VSIIVYSVLFLIAAVGNLTVLLILLRNRRRKrSRVNILLMHLAIADLLVTFIMMPLEIGwaatvawlagDFLCR--LMLF 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 116174762  93 necmTQVFALHLfgcmEIFVLILMAVDRYVAICKPLRypVIMSRQVCVILIILAWIGSFIHSTAQIVL 160
Cdd:cd15382   80 ----FRAFGLYL----SSFVLVCISLDRYFAILKPLR--LSDARRRGRIMLAVAWVISFLCSIPQSFI 137

7tmA_MC5R

cd15354

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...

28-147

1.20e-04

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.

Pssm-ID: 320476 [Multi-domain] Cd Length: 270 Bit Score: 43.00 E-value: 1.20e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  28 IFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTA-PRLIVDALSKKNIISYNECMTQV------- 99
Cdd:cd15354    6 VFLTLGIISLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSNAwETITIYLLNNRHLVIEDAFVRHIdnvfdsl 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 116174762 100 FALHLFGCMeiFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAW 147
Cdd:cd15354   86 ICISVVASM--CSLLAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIW 131

7tmA_MCHR-like

cd15088

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...

28-287

1.54e-04

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320216 [Multi-domain] Cd Length: 278 Bit Score: 42.44 E-value: 1.54e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  28 IFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTaPRLIvDALSKKNIISYNECM-TQVFAL---H 103
Cdd:cd15088    6 VFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGM-PFLI-HQFAIDGQWYFGEVMcKIITALdanN 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 104 LFGCmeIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPNLIdhycCDLQpLL 183
Cdd:cd15088   84 QFTS--TYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFPDGTTF----CYVS-LP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 184 KLACMDTYMINLLLVSnsgaiCSSSFVILIISYFVILHSLRNHSAEGR----KKALSTCTSHIIVVILFFGPCIFIY--- 256
Cdd:cd15088  157 SPDDLYWFTIYHFILG-----FAVPLVVITVCYILILHRLARGVAPGNqshgSSRTKRVTKMVILIVVVFIVCWLPFhvv 231

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 116174762 257 -------ARPPTTFsmdkMVAVFYTIGTPF----LNPIIYTL 287
Cdd:cd15088  232 qlvnlamNRPTLAF----EVAYFLSICLGYanscLNPFVYIL 269

7tmA_AstC_insect

cd15094

somatostatin-like receptor for allatostatin C, member of the class A family of ...

30-152

1.80e-04

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.

Pssm-ID: 320222 [Multi-domain] Cd Length: 282 Bit Score: 42.46 E-value: 1.80e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  30 LVFYLGtVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTaPRLIVDALSKKNIISYNECMTQVFALHLFGCME 109
Cdd:cd15094    9 LICIVG-LVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGL-PFLIVTMILKYWPFGAAMCKIYMVLTSINQFTS 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 116174762 110 IFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFI 152
Cdd:cd15094   87 SFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFL 129

7tmA_DmOct-betaAR-like

cd15066

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...

24-150

1.86e-04

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.

Pssm-ID: 320194 [Multi-domain] Cd Length: 265 Bit Score: 42.36 E-value: 1.86e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIflvfyLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALH 103
Cdd:cd15066    6 MTLII-----LAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNSLDV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGS 150
Cdd:cd15066   81 YFSTASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISP 127

7tmA_purinoceptor-like

cd14982

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...

29-285

2.13e-04

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341318 [Multi-domain] Cd Length: 283 Bit Score: 42.25 E-value: 2.13e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  29 FLVFYLGtVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFsTSTAPRLIVDALSKKNIISYNE-CMTQVFALHLFGC 107
Cdd:cd14982    8 SLIFILG-LLGNILALWVFLRKMKKRSPTTIYMINLALADLLF-VLTLPFRIYYYLNGGWWPFGDFlCRLTGLLFYINMY 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 108 MEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAqiVLALRLPFCGPNLIDHyCCDLQPLLKLAC 187
Cdd:cd14982   86 GSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVP--LLLLRSTIAKENNSTT-CFEFLSEWLASA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 188 MdtYMINLLLVsnsgAICSSSFVILIISYFVILHSLR---NHSAEG--RKKALSTCTSHIIVVILFFGP---CIFIYARP 259
Cdd:cd14982  163 A--PIVLIALV----VGFLIPLLIILVCYSLIIRALRrrsKQSQKSvrKRKALRMILIVLAVFLVCFLPyhvTRILYLLV 236

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 116174762 260 PTTF----SMDKMVAVFYTIGTPF------LNPIIY 285
Cdd:cd14982  237 RLSFiadcSARNSLYKAYRITLCLaslnscLDPLIY 272

7tmA_CCK-AR

cd15978

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...

25-166

2.13e-04

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.

Pssm-ID: 320644 [Multi-domain] Cd Length: 278 Bit Score: 42.16 E-value: 2.13e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  25 VFIIFLVFYLgTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHL 104
Cdd:cd15978    4 ILLYSLIFLL-SVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMGI 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116174762 105 FGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPF 166
Cdd:cd15978   83 SVSVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPF 144

7tmA_mAChR_M3

cd15299

muscarinic acetylcholine receptor subtype M3, member of the class A family of ...

23-152

2.18e-04

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320426 [Multi-domain] Cd Length: 274 Bit Score: 42.24 E-value: 2.18e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  23 KMVFIIFL--VFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVF 100
Cdd:cd15299    2 QVVLIAFLtgILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLS 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 116174762 101 ALHLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFI 152
Cdd:cd15299   82 IDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFV 133

7tmA_alpha2B_AR

cd15321

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

27-295

2.42e-04

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320444 [Multi-domain] Cd Length: 268 Bit Score: 41.83 E-value: 2.42e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYlgTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFG 106
Cdd:cd15321   13 ITFLILF--TIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLFC 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 107 CMEIFVLILMAVDRYVAICKPLRY-PVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFCGPnlidhyccdlQPLLKL 185
Cdd:cd15321   91 TSSIVHLCAISLDRYWSVSRAIEYnSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQKDEQGG----------LPQCKL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMInlllvsnSGAICS--SSFVILIISYFVILHSLRNhsaegRKKALSTCTSHII-VVILFFGPCIFIYAR---- 258
Cdd:cd15321  161 NEEAWYIL-------SSSIGSffAPCLIMILVYLRIYLIAKN-----REKRFTFVLAVVIgVFVLCWFPFFFSYSLgaic 228

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 116174762 259 PPTTFSMDKMVAVFYTIG--TPFLNPIIYTLRNAEVKNA 295
Cdd:cd15321  229 PELCKVPHSLFQFFFWIGycNSSLNPVIYTIFNQDFRRA 267

7tmA_mAChR_M1

cd17790

muscarinic acetylcholine receptor subtype M1, member of the class A family of ...

25-152

2.74e-04

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341356 [Multi-domain] Cd Length: 262 Bit Score: 41.88 E-value: 2.74e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  25 VFIIFL--VFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADscfststaprLIVDALSKKNIISYneCMTQVFAL 102
Cdd:cd17790    1 VLIVITtgILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACAD----------LIIGAFSMNLYTTY--ILMGHWAL 68

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116174762 103 HLFGC------------MEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFI 152
Cdd:cd17790   69 GTVACdlwlaldyvasnASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFV 130

7tmA_Chemokine_R

cd14984

classical and atypical chemokine receptors, member of the class A family of ...

30-249

3.25e-04

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.

Pssm-ID: 341319 [Multi-domain] Cd Length: 278 Bit Score: 41.43 E-value: 3.25e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  30 LVFYLGtVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTsTAPRLIVDALsKKNIISYNEC--MTQVFALHLFGC 107
Cdd:cd14984    9 LVFLLG-LVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVL-TLPFWAVYAA-DGWVFGSFLCklVSALYTINFYSG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 108 MeiFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALrlpfCGPNLIDHYCcdlQPLLKLAC 187
Cdd:cd14984   86 I--LFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQ----VSEENGSSIC---SYDYPEDT 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116174762 188 MDTYMINLLLVSNSGAICsSSFVILIISYFVILHSLRNHSAEGRKKALSTCtshIIVVILFF 249
Cdd:cd14984  157 ATTWKTLLRLLQNILGFL-LPLLVMLFCYSRIIRTLLRARNHKKHRALRVI---FAVVVVFF 214

7tmA_Adenosine_R_A2A

cd15068

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...

27-152

3.54e-04

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.

Pssm-ID: 320196 [Multi-domain] Cd Length: 293 Bit Score: 41.46 E-value: 3.54e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIvdALSKKNIISYNECMTQVFALHLFG 106
Cdd:cd15068    5 TVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAI--TISTGFCAACHGCLFIACFVLVLT 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 116174762 107 CMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFI 152
Cdd:cd15068   83 QSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFA 128

7tmA_V1bR

cd15386

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...

111-163

3.62e-04

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320508 [Multi-domain] Cd Length: 302 Bit Score: 41.71 E-value: 3.62e-04

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 116174762 111 FVLILMAVDRYVAICKPLRYPVIMSRQVCvILIILAWIGSFIHSTAQI-VLALR 163
Cdd:cd15386   89 YMLIMMTVDRYIAVCHPLRTLQQPSRQAY-LMIGATWLLSCILSLPQVfIFSLR 141

7tmA_D2-like_dopamine_R

cd15053

D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...

27-295

4.29e-04

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.

Pssm-ID: 320181 [Multi-domain] Cd Length: 263 Bit Score: 41.18 E-value: 4.29e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPrlivdalskknIISYNECMTQVFAL---- 102
Cdd:cd15053    5 LFLLLLPLLTVFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMP-----------FAVYVEVNGGKWYLgpil 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 103 -HLFGCME-------IFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFihstaqivlALRLPFcgpnlidh 174
Cdd:cd15053   74 cDIYIAMDvmcstasIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSA---------AIACPL-------- 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 175 yccdlqpLLKLACMDTYMINLLLVSNSGAICSSS-------FVILIISYFVILHSLRNhsaegRKKALST---------- 237
Cdd:cd15053  137 -------LFGLNNVPYRDPEECRFYNPDFIIYSSissfyipCIVMLLLYYRIFRALRR-----EKKATKTlaivlgvflf 204

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 116174762 238 CTSHIIVVILFFGPCIFIYAR----PPTTFSMdkmvAVFYTIGTPFLNPIIYTLRNAEVKNA 295
Cdd:cd15053  205 CWLPFFTLNILNAICPKLQNQschvGPALFSL----TTWLGYVNSFLNPIIYTIFNIEFRKA 262

7tmA_alpha2C_AR

cd15323

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...

29-295

4.63e-04

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320446 [Multi-domain] Cd Length: 261 Bit Score: 41.08 E-value: 4.63e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  29 FLVFYlgTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFGCM 108
Cdd:cd15323    9 FLIVF--TIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 109 EIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFcgpnlidhycCDLQPLLKLAcM 188
Cdd:cd15323   87 SIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRDPE----------GDVYPQCKLN-D 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 189 DTYMINLLLVSNSGAICsssfVILIISYFVILhslrnHSAEGRKKALSTCTSHII-VVILFFGPCIFIYA-----RPPTT 262
Cdd:cd15323  156 ETWYILSSCIGSFFAPC----LIMILVYIRIY-----RVAKAREKRFTFVLAVVMgVFVVCWFPFFFSYSlygicREACE 226

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 116174762 263 FSmDKMVAVFYTIG--TPFLNPIIYTLRNAEVKNA 295
Cdd:cd15323  227 VP-EPLFKFFFWIGycNSSLNPVIYTIFNQDFRRS 260

7tmA_Adenosine_R_A1

cd15071

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...

31-152

4.72e-04

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.

Pssm-ID: 341323 [Multi-domain] Cd Length: 290 Bit Score: 40.99 E-value: 4.72e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  31 VFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNiiSYNECMTQVFALHLFGCMEI 110
Cdd:cd15071    9 LIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIIINIGPQT--EFYSCLMVACPVLILTQSSI 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 116174762 111 FVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFI 152
Cdd:cd15071   87 LALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFL 128

7tmA_Parietopsin

cd15085

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...

24-128

4.94e-04

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.

Pssm-ID: 320213 [Multi-domain] Cd Length: 280 Bit Score: 40.99 E-value: 4.94e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLgTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALH 103
Cdd:cd15085    3 LSFLMFLNATF-SIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQGFAVN 81

                         90       100
                 ....*....|....*....|....*
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPL 128
Cdd:cd15085   82 YFGIVSLWSLTLLAYERYNVVCKPM 106

7tmA_5-HT2A

cd15304

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...

27-295

4.98e-04

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341345 [Multi-domain] Cd Length: 267 Bit Score: 41.07 E-value: 4.98e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSK-KNIISYNECMTQVFALHLF 105
Cdd:cd15304    5 LLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGyRWPLPSKLCAVWIYLDVLF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWigsfihsTAQIVLALRLPFCGpnLIDhyccDLQPLLKL 185
Cdd:cd15304   85 STASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVW-------TISVGISMPIPVFG--LQD----DSKVFKEG 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACmdtyminllLVSNSGAICSSSFV-------ILIISYFVILHSLRNHSAEGRKKALSTCTSHIIVVIL----FFGPCIF 254
Cdd:cd15304  152 SC---------LLADENFVLIGSFVaffipltIMVITYFLTIKSLQQSISNEQKASKVLGIVFFLFVVMwcpfFITNVMA 222

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 116174762 255 IYARPPTT-FSMDKMVAVFYTIG--TPFLNPIIYTLRNAEVKNA 295
Cdd:cd15304  223 VICKESCNeVVIGGLLNVFVWIGylSSAVNPLVYTLFNKTYRSA 266

7tmA_Mel1A

cd15402

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...

37-152

5.59e-04

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320524 [Multi-domain] Cd Length: 279 Bit Score: 41.04 E-value: 5.59e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  37 VVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFGCMEIFVLILM 116
Cdd:cd15402   15 ILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMGLSVIGSIFNITGI 94

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 116174762 117 AVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFI 152
Cdd:cd15402   95 AINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVA 130

7tmA_5-HT2C

cd15305

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...

27-295

5.76e-04

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341346 [Multi-domain] Cd Length: 275 Bit Score: 40.66 E-value: 5.76e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNI-ISYNECMTQVFALHLF 105
Cdd:cd15305    5 LLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYAWpLPRYLCPIWISLDVLF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWigsfihsTAQIVLALRLPFCGpnlidhyccdLQPLLKL 185
Cdd:cd15305   85 STASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVW-------TISIGISMPIPVIG----------LQDDEKV 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMIN--LLLVSNSGAICSSSFVILIISYFVILHSLRNHSAEGRKKALSTCTSHIIVVILFFGPCIFIY------- 256
Cdd:cd15305  148 FVNGTCVLNdeNFVLIGSFVAFFIPLIIMVITYCLTIQVLQRQQAINNERRASKVLGIVFFLFLIMWCPFFITnilsvlc 227

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 116174762 257 ARPPTTFSMDKMVAVFYTIG--TPFLNPIIYTLRNAEVKNA 295
Cdd:cd15305  228 KEACDQKLMEELLNVFVWVGyvSSGINPLVYTLFNKTYRRA 268

7tmA_ETH-R

cd14997

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...

24-154

8.51e-04

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320128 [Multi-domain] Cd Length: 294 Bit Score: 40.35 E-value: 8.51e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLGtVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIIsYNECMTQVFALH 103
Cdd:cd14997    3 VSVVYGVIFVVG-VLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVETWAREPWL-LGEFMCKLVPFV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 116174762 104 LFGCMEIFVLILMA--VDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHS 154
Cdd:cd14997   81 ELTVAHASVLTILAisFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTS 133

7tmA_GPR84-like

cd15210

G protein-coupled receptor 84 and similar proteins, member of the class A family of ...

37-151

9.72e-04

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.

Pssm-ID: 320338 [Multi-domain] Cd Length: 254 Bit Score: 39.94 E-value: 9.72e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  37 VVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECmtQVFALHLFGC--MEIFVLI 114
Cdd:cd15210   15 VPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLC--RVFPLLRYGLvaVSLLTLV 92

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 116174762 115 LMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSF 151
Cdd:cd15210   93 LITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSF 129

7tmA_Mel1

cd15209

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...

37-148

9.75e-04

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320337 [Multi-domain] Cd Length: 279 Bit Score: 40.15 E-value: 9.75e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  37 VVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFGCMEIFVLILM 116
Cdd:cd15209   15 VLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGLSVIGSIFNITAI 94

                         90       100       110
                 ....*....|....*....|....*....|..
gi 116174762 117 AVDRYVAICKPLRYPVIMSRQVCVILIILAWI 148
Cdd:cd15209   95 AINRYCYICHSLQYDRLYSLRNTCCYLCLTWL 126

7tmA_Cannabinoid_R

cd15099

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...

36-296

9.76e-04

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 320227 [Multi-domain] Cd Length: 281 Bit Score: 40.21 E-value: 9.76e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  36 TVVGNTLIIMTIKFSRTLG-SPMYFFLFYLSFAD---SCFSTSTAprLIVDALSKKNiisynecMTQVFALHLFGCMEIF 111
Cdd:cd15099   14 TFLENILVLLTILSSTALRrRPSYLFIGSLALADmlaSVIFTISF--LDFHVFHQRD-------SRNLFLFKLGGVTMAF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 112 V-----LILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWigsfihsTAQIVLALrLPFCGPNL--IDHYCCDLQPLLK 184
Cdd:cd15099   85 TasvgsLLLTALDRYLCIYQPSNYKLLVTRTRAKVAILLMW-------CVTIIISF-LPLMGWRCktWDSPCSRLFPYID 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 185 lacmDTYMINLLLVSnsgaicSSSFVILIISYFVILHSLRNHSAE------GRKKA-----------LSTCTSHIIVVIL 247
Cdd:cd15099  157 ----RHYLASWTGLQ------LVLLFLIIYAYPYILWKAHRHEANmggpklGRQQVkgqarmrmdirLAKTLSLILLVLA 226

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 116174762 248 F-FGPCIFIYARPPTTFSMDKMVAVFYTIGTPFL-----NPIIYTLRNAEVKNAM 296
Cdd:cd15099  227 IcWLPVLAFMLVDVRVTLTNKQKRMFAFCSMLCLvnscvNPIIYALRSRELRGAM 281

7tmA_GHSR-like

cd15928

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...

25-160

1.05e-03

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.

Pssm-ID: 320594 [Multi-domain] Cd Length: 288 Bit Score: 40.17 E-value: 1.05e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  25 VFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFST----------STAPRLIVDALSKKNIIsYNE 94
Cdd:cd15928    3 VTAVCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLvlpldlyrlwRYRPWRFGDLLCRLMYF-FSE 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 116174762  95 CMTQVFALHLFGcmeifvlilMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVL 160
Cdd:cd15928   82 TCTYASILHITA---------LSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVL 138

7tmA_NPFFR

cd15207

neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...

25-160

1.08e-03

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.

Pssm-ID: 320335 [Multi-domain] Cd Length: 291 Bit Score: 39.91 E-value: 1.08e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  25 VFII--FLVFyLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFAL 102
Cdd:cd15207    2 LFIVsySLIF-LLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVGVFCMPFTLVDNILTGWPFGDVMCKLSPLVQ 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 116174762 103 HLFGCMEIFVLILMAVDRYVAICKPLRYPviMSRQVCVILIILAWIGSFIHSTAQIVL 160
Cdd:cd15207   81 GVSVAASVFTLVAIAVDRYRAVVHPTEPK--LTNRQAFVIIVAIWVLALAIMIPQALV 136

7tmA_Histamine_H3R_H4R

cd15048

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...

27-151

1.13e-03

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320176 [Multi-domain] Cd Length: 296 Bit Score: 39.98 E-value: 1.13e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFG 106
Cdd:cd15048    5 VLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVDYTLC 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 116174762 107 CMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSF 151
Cdd:cd15048   85 TASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAF 129

7tmA_Gal1_R

cd15098

galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...

24-252

1.45e-03

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.

Pssm-ID: 320226 [Multi-domain] Cd Length: 282 Bit Score: 39.71 E-value: 1.45e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIF-LVFYLGtVVGNTLIIMTIKFSRTLG--SPMYFFLFYLSFADSCF---------STSTAPRLIVDALSKKnIIS 91
Cdd:cd15098    2 IVPVVFgLIFCLG-VLGNSLVITVLARVKPGKrrSTTNVFILNLSIADLFFllfcvpfqaTIYSLPEWVFGAFMCK-FVH 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  92 YNECMTQVfalhlfgcMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFihSTAQIVLALRLPFCGPNL 171
Cdd:cd15098   80 YFFTVSML--------VSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSL--AMASPVAVHQDLVHHWTA 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 172 IDHYCCDLQPLLKLACMdTYMINLLLVsnsGAICssSFVILIISYFVILHSLRNHSAEGRKKALST---CTSHIIVVILF 248
Cdd:cd15098  150 SNQTFCWENWPEKQQKP-VYVVCTFVF---GYLL--PLLLITFCYAKVLNHLHKKLKNMSKKSERSkkkTAQTVLVVVVV 223


                 ....
gi 116174762 249 FGPC 252
Cdd:cd15098  224 FGIS 227

7tmA_alpha-2D_AR

cd15324

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...

24-160

1.50e-03

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.

Pssm-ID: 320447 [Multi-domain] Cd Length: 256 Bit Score: 39.47 E-value: 1.50e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALH 103
Cdd:cd15324    2 LIVLVVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALDV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVL 160
Cdd:cd15324   82 LFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLLM 138

7tmA_PR4-like

cd15392

neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...

110-152

1.59e-03

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.

Pssm-ID: 320514 [Multi-domain] Cd Length: 287 Bit Score: 39.65 E-value: 1.59e-03

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 116174762 110 IFVLILMAVDRYVAICKPLRYPviMSRQVCVILIILAWIGSFI 152
Cdd:cd15392   89 AFTLVAISIDRYVAIMWPLRPR--MTKRQALLLIAVIWIFALA 129

7tmA_SREB3_GPR173

cd15217

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...

36-147

1.62e-03

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320345 [Multi-domain] Cd Length: 329 Bit Score: 39.55 E-value: 1.62e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  36 TVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVdALSKKNIISYN--ECMTQVFALHLFGCMEIFVL 113
Cdd:cd15217   14 SLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLV-SIRNGSAWTYSvlSCKIVAFMAVLFCFHAAFML 92

                         90       100       110
                 ....*....|....*....|....*....|....
gi 116174762 114 ILMAVDRYVAICKPLRYPVIMSRQVCVILIILAW 147
Cdd:cd15217   93 FCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVW 126

7tmA_Mel1C

cd15401

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...

37-148

2.06e-03

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320523 [Multi-domain] Cd Length: 279 Bit Score: 39.12 E-value: 2.06e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  37 VVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFGCMEIFVLILM 116
Cdd:cd15401   15 VLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMGLSVIGSVFNITAI 94

                         90       100       110
                 ....*....|....*....|....*....|..
gi 116174762 117 AVDRYVAICKPLRYPVIMSRQVCVILIILAWI 148
Cdd:cd15401   95 AINRYCYICHSLRYDKLYNMKKTCCYVCLTWV 126

7tmA_TAAR1

cd15314

trace amine-associated receptor 1 and similar receptors, member of the class A family of ...

110-162

2.09e-03

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320438 [Multi-domain] Cd Length: 282 Bit Score: 39.15 E-value: 2.09e-03

                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 116174762 110 IFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVLAL 162
Cdd:cd15314   88 ILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFGIIFLEL 140

7tmA_GPR25

cd15193

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...

27-287

2.36e-03

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.

Pssm-ID: 320321 [Multi-domain] Cd Length: 279 Bit Score: 38.96 E-value: 2.36e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFG 106
Cdd:cd15193    5 ILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTALGGQWLFGEGLCKLSSFIIAVNR 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 107 CMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIhsTAQIVLALRlpfcgpNLIDH-YCCDLQPLLKL 185
Cdd:cd15193   85 CSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLV--LGIPSLVYR------NLINEsVCVEDSSSRFF 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 186 ACMDTYMINLLLVSnsgaicssSFVILIISYFVILHSLRNHSAEGRKKALSTCTSHIIVV------------------IL 247
Cdd:cd15193  157 QGISLATLFLTFVL--------PLIVILFCYCSILVRLRRHFHGAKRTGRRRRNSLRIVFaivtafvlswlpfntlkaVR 228

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 116174762 248 FFGPCIFIYARPPTTFSMDKMVAVFYTIG--TPFLNPIIYTL 287
Cdd:cd15193  229 LLLELGGGVLPCHTTVAIRQGLTITACLAfvNSCVNPLIYSL 270

7tmA_Galanin_R-like

cd14971

galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...

24-150

2.44e-03

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.

Pssm-ID: 320102 [Multi-domain] Cd Length: 281 Bit Score: 38.99 E-value: 2.44e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALH 103
Cdd:cd14971    2 IVPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQ 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 116174762 104 LFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGS 150
Cdd:cd14971   82 VSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVS 128

7tmA_CB1

cd15340

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G ...

27-295

2.65e-03

cannabinoid receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 320462 [Multi-domain] Cd Length: 292 Bit Score: 38.74 E-value: 2.65e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGT--VVGNTLIIMTIKFSRTLGS-PMYFFLFYLSFADSCFSTSTAPRLI-VDALSKKNiisynecMTQVFAL 102
Cdd:cd15340    3 IAVLSLTLGTftVLENLLVLCVILHSRSLRCrPSYHFIGSLAVADLLGSVIFVYSFLdFHVFHRKD-------SPNVFLF 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 103 HLFGCMEIFV-----LILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWigsfihsTAQIVLALrLPFCGPNL--IDHY 175
Cdd:cd15340   76 KLGGVTASFTasvgsLFLTAIDRYISIHRPLAYKRIVTRTKAVIAFCVMW-------TIAIVIAV-LPLLGWNCkkLNSV 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 176 CCDLQPLLKlacmDTYMINLLLVSnsgaicSSSFVILIISYFVILHSLRNHS----AEGRKKALSTCTSH---------- 241
Cdd:cd15340  148 CSDIFPLID----ETYLMFWIGVT------SVLLLFIVYAYMYILWKAHHHAvrmlQRGTQKSIIVYTSEdgkvqttrpd 217

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 116174762 242 ---------------IIVVILFFGPCIFIYARP---------PTTFSMDKMVAVFYTIgtpfLNPIIYTLRNAEVKNA 295
Cdd:cd15340  218 qtrmdirlaktlvliLVVLIICWGPLLAIMVYDvfgkmnkliKTVFAFCSMLCLLNST----VNPIIYALRSKDLRHA 291

7tmA_VA_opsin

cd15082

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...

27-293

3.10e-03

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320210 [Multi-domain] Cd Length: 291 Bit Score: 38.62 E-value: 3.10e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFsRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFG 106
Cdd:cd15082   19 LMFVVTSLSLAENFAVMLVTFRF-KQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFFLGVWACVLEGFAVTFFG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 107 CMEIFVLILMAVDRYVAICKPLRYPVIMSRQVcVILIILAWIGSFIhstaqivlalrlpfcgpnlidhycCDLQPLLKLA 186
Cdd:cd15082   98 IVALWSLAVLAFERFFVICRPLGNIRLQGKHA-ALGLLFVWTFSFI------------------------WTIPPVLGWS 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 187 CMDTYMINLLLVSN--SGAICSSSFVI-------------LIISYFVILHSLRNHS-AEGR----KKALSTCTSHIIVVI 246
Cdd:cd15082  153 SYTVSKIGTTCEPNwySGNMHDHTYIItffttcfilplgvIFVSYGKLLQKLRKVSnTQGRlgnaRKPERQVTRMVVVMI 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 116174762 247 LFFGPC--------IFIYARPptTFSMDKMVA---VFYTIGTPFLNPIIYTLRNAEVK 293
Cdd:cd15082  233 VAFMVCwtpyaafsILVTAHP--TIHLDPRLAaipAFFSKTAAVYNPIIYVFMNKQFR 288

7tmA_Beta3_AR

cd15959

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...

34-159

3.31e-03

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320625 [Multi-domain] Cd Length: 302 Bit Score: 38.73 E-value: 3.31e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  34 LGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNEC--MTQVFALHLFGCMEif 111
Cdd:cd15959   12 LVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCelWTSVDVLCVTASIE-- 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 116174762 112 VLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIV 159
Cdd:cd15959   90 TLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPIM 137

7tmA_tyramine_octopamine_R-like

cd15060

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...

27-295

3.42e-03

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320188 [Multi-domain] Cd Length: 260 Bit Score: 38.18 E-value: 3.42e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFG 106
Cdd:cd15060    5 ILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVAIFVLPLNVAYFLLGKWLFGIHLCQMWLTCDILCC 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 107 CMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIhstaqivlalrlpFCGPNLIDHYCCDLQPLLKLA 186
Cdd:cd15060   85 TASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSAL-------------ISVPPLIGWNDWPENFTETTP 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 187 CMDTYMINLLLVSNSGaicsSSFVILIISYFVILHSLRNHSAEgrKKALSTCTSHIIVVILFFGPCIFIYARPP--TTFS 264
Cdd:cd15060  152 CTLTEEKGYVIYSSSG----SFFIPLLIMTIVYVKIFIATSKE--RRAARTLGIIMGVFVVCWLPFFLMYVILPfcETCS 225

                        250       260       270
                 ....*....|....*....|....*....|....
gi 116174762 265 MDKMVAVFYT-IG--TPFLNPIIYTLRNAEVKNA 295
Cdd:cd15060  226 PSAKVVNFITwLGyvNSALNPVIYTIFNLDFRRA 259

7tmA_NPR-like_invertebrate

cd15391

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...

27-161

4.07e-03

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.

Pssm-ID: 320513 [Multi-domain] Cd Length: 289 Bit Score: 38.26 E-value: 4.07e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFG 106
Cdd:cd15391    5 NLYQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSV 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 116174762 107 CMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIIlaWIGSFIHSTAQIVLA 161
Cdd:cd15391   85 TASVLTNTAIGIDRFFAVIFPLRSRHTKSRTKCIIASI--WAISFSLSSVQLFAG 137

7tmA_Beta2_AR

cd15957

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...

27-154

4.46e-03

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.

Pssm-ID: 341355 [Multi-domain] Cd Length: 301 Bit Score: 38.31 E-value: 4.46e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  27 IIFLVFYLGTVVGNTLIIMTI-KFSRtLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15957    5 IVMSLIVLAIVFGNVLVITAIaKFER-LQTVTNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLC 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHS 154
Cdd:cd15957   84 VTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTS 132

7tmA_QRFPR

cd15205

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...

26-152

4.94e-03

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.

Pssm-ID: 320333 [Multi-domain] Cd Length: 298 Bit Score: 37.84 E-value: 4.94e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  26 FIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLF 105
Cdd:cd15205    4 VITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQSTA 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 116174762 106 GCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFI 152
Cdd:cd15205   84 VVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVI 130

7tmA_Pinopsin

cd15084

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...

30-299

5.45e-03

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320212 [Multi-domain] Cd Length: 295 Bit Score: 37.92 E-value: 5.45e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  30 LVFYLGTVVGNTLIIMTIKFSRtLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFGCME 109
Cdd:cd15084   19 MVVALASFVNGLVIVVSIKYKK-LRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEFEGFMVSLTGIVG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 110 IFVLILMAVDRYVAICKPLRyPVIMSRQVCVILIILAWIGSFIHSTAqivlalrlPFCGpnlidhYCCDLQPLLKLACMD 189
Cdd:cd15084   98 LWSLAILAFERYLVICKPMG-DFRFQQRHAVSGCAFTWGWSLLWTSP--------PLFG------WSSYVPEGLRTSCGP 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 190 TYMINlllVSNSGAICSSSFV--------ILIISYFVILHSLRNHSA-----EGRKKALSTCTSHIIVVILFFGPCIFIY 256
Cdd:cd15084  163 NWYTG---GTNNNSYILALFVtcfalplsTIIFSYSNLLLTLRAVAAqqkesETTQRAEKEVTRMVIAMVMAFLICWLPY 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 116174762 257 ARPPTTFSMDKMVAV---------FYTIGTPFLNPIIYTLRNAEVKNAMKKL 299
Cdd:cd15084  240 ATFAMVVATNKDVVIqptlaslpsYFSKTATVYNPIIYVFMNKQFRSCLLEL 291

7tmA_5-HT4

cd15056

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...

31-152

5.59e-03

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320184 [Multi-domain] Cd Length: 294 Bit Score: 37.85 E-value: 5.59e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  31 VFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFGCMEI 110
Cdd:cd15056    9 LVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVAVLVMPFGAIELVNNRWIYGETFCLVRTSLDVLLTTASI 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 116174762 111 FVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFI 152
Cdd:cd15056   89 MHLCCIALDRYYAICCQPLVYKMTPLRVAVMLGGCWVIPTFI 130

7tmA_mAChR_GAR-2-like

cd15302

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...

24-148

5.92e-03

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320429 [Multi-domain] Cd Length: 266 Bit Score: 37.80 E-value: 5.92e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  24 MVFIIFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALS-KKNIISYNECMTQVFAL 102
Cdd:cd15302    2 LLALITAILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIGLESMPFYTVYVLNgDYWPLGWVLCDLWLSVD 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 116174762 103 HLFGCMEIFVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWI 148
Cdd:cd15302   82 YTVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWI 127

7tmA_SWS1_opsin

cd15076

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...

30-148

7.54e-03

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320204 [Multi-domain] Cd Length: 280 Bit Score: 37.49 E-value: 7.54e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  30 LVFYLGTVVGNTLIIMTIKFSRtLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFGCME 109
Cdd:cd15076    9 FVFIVGTPLNAIVLFVTIKYKK-LRQPLNYILVNISLAGFIFCIFSVFPVFVASAQGYFFFGRTVCALEAFVGSLAGLVT 87

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 116174762 110 IFVLILMAVDRYVAICKPLRYPVIMSRQVcVILIILAWI 148
Cdd:cd15076   88 GWSLAFLAFERYIVICKPFGNFRFGSKHA-LGAVVATWI 125

7tmA_mAChR_M5

cd15300

muscarinic acetylcholine receptor subtype M5, member of the class A family of ...

31-152

7.81e-03

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320427 [Multi-domain] Cd Length: 262 Bit Score: 37.31 E-value: 7.81e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  31 VFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFGCMEI 110
Cdd:cd15300    9 VVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWLALDYVASNASV 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 116174762 111 FVLILMAVDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFI 152
Cdd:cd15300   89 MNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFI 130

7tmA_Mel1B

cd15400

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...

37-148

7.89e-03

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.

Pssm-ID: 320522 [Multi-domain] Cd Length: 279 Bit Score: 37.14 E-value: 7.89e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  37 VVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIVDALSKKNIISYNECMTQVFALHLFGCMEIFVLILM 116
Cdd:cd15400   15 ILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVMGLSVIGSIFNITGI 94

                         90       100       110
                 ....*....|....*....|....*....|..
gi 116174762 117 AVDRYVAICKPLRYPVIMSRQVCVILIILAWI 148
Cdd:cd15400   95 AINRYCYICHSFAYDKLYSRWNTLLYVCLIWA 126

COG5543

Uncharacterized conserved protein [Function unknown];

121-291

8.01e-03

Uncharacterized conserved protein [Function unknown];

Pssm-ID: 227830 [Multi-domain] Cd Length: 1400 Bit Score: 38.06 E-value: 8.01e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  121 YVAICKPLRYPVIMSRQVCVIL-----IILAWIGSFIHSTAQIVLALRLPFCGPNLIDHyccDLQPLLKLACMDTYM--- 192
Cdd:COG5543   414 YLEVIKPMLRPTNAYQRVLGSLylmdsLIAEGIDKSTPQKFLIQNKREFPFSAQLLFDS---DHERLMIDLLVSNYAdir 490

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  193 -----INLLLVSNSGAICSSSFVILIISYFVILHSLRNHSAEGRKKALSTCTSHIIVVI--LFFGPCIFIYARPPTTFSM 265
Cdd:COG5543   491 klstkILLGLESMSESRGLFLDTLDANALKVKIESHQSHDVHGDAGATVYCVEFIKSCQsrSFVGHTKSILDSHMKNFVS 570

                         170       180
                  ....*....|....*....|....*..
gi 116174762  266 DKMVAVFYTIGTPFLN-PIIYTLRNAE 291
Cdd:COG5543   571 GKKSMEEISIGPHFAAlSLILGLFNSE 597

7tmA_capaR

cd15134

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...

112-295

8.47e-03

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.

Pssm-ID: 320262 [Multi-domain] Cd Length: 298 Bit Score: 37.31 E-value: 8.47e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 112 VLILMA--VDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIhstaqivlaLRLPFCGPNLIDHYccDLQPLLKLACMD 189
Cdd:cd15134   89 VLTITAfsVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFV---------CALPFAIQTRIVYL--EYPPTSGEALEE 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 190 TYMINLL--LVSNSGAICSSSFV-------ILIISYFVI---LHS----LRNHSAEGRKKALSTCTSHII-----VVILF 248
Cdd:cd15134  158 SAFCAMLneIPPITPVFQLSTFLffiipmiAIIVLYVLIglqLRRstllRRGQRSVSGGRRSSQSRRTVLrmlvaVVVAF 237

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762 249 F---GP-----CIFIYARPPTTFSMDKMVAVFYTIGTPF-----LNPIIYTLRNAEVKNA 295
Cdd:cd15134  238 FicwAPfhaqrLLTVYAKNMTPPYLFINRILFYISGVLYyvsstVNPILYNVMSAKYRQA 297

7tmA_GHSR

cd15131

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...

30-160

8.54e-03

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.

Pssm-ID: 320259 [Multi-domain] Cd Length: 291 Bit Score: 37.17 E-value: 8.54e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  30 LVFYLGtVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFSTSTAPRLIvdALSKKNIISYNECMTQVFALHLFGCME 109
Cdd:cd15131    9 LLFVVG-VTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPLDLY--RLWQYRPWNFGDLLCKLFQFVSESCTY 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 116174762 110 IFVLILMA--VDRYVAICKPLRYPVIMSRQVCVILIILAWIGSFIHSTAQIVL 160
Cdd:cd15131   86 STILNITAlsVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGPIFVL 138

7tmA_V2R

cd15388

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...

28-181

9.49e-03

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320510 [Multi-domain] Cd Length: 295 Bit Score: 37.06 E-value: 9.49e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116174762  28 IFLVFYLGTVVGNTLIIMTIKFSRTLGSPMYFFLFYLSFADSCFST-STAPRLIVDAlsKKNIISYNECMTQVFALHLFG 106
Cdd:cd15388    6 VLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVAFfQVLPQLVWDI--TDRFRGPDVLCRLVKYLQVVG 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 116174762 107 CM-EIFVLILMAVDRYVAICKPLrYPVIMSRQVCVILIILAWIGSFIHSTAQIVLALRLPFcGPNLIDHYCCDLQP 181
Cdd:cd15388   84 MFaSSYMIVAMTFDRHQAICRPM-VTFQKGRARWNGPVCVAWAISLILSLPQVFIFSKVEV-APGVYECWACFIEP 157

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01