CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138546 804 CGGEL-GEFTGYIESPNYPGNYPAGVECVWNINPPPKRKILIVVPEIFLPSEDECG-DVLVMRKNSSPSSITTYETCqTY 881
Cdd:cd00041   1 CGGTLtASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSyDYLEIYDGPSTSSPLLGRFC-GS 79

                        90       100       110
                ....*....|....*....|....*....|....
gi 52138546 882 ERPIAFTARSRKLWINFKTSEANSARGFQIPYVT 915
Cdd:cd00041  80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 52138546   752 GHYYNTSIHRCIRCAVGSYQPDFRQNFCTRCPGNTSTDFDGSTSVAQC 799
Cdd:pfam07699   1 GTYSNTGLEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 52138546   642 GTYYHGQTEQCVPCPAGTFQEREGQLSCDLCPGSDAHGPLGATNVTTC 689
Cdd:pfam07699   1 GTYSNTGLEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 52138546   281 CRLNNGGCDHICRNTVGSFECSCKKGYKLLINERSC 316
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 52138546   201 CNYGNGGCQHTCDDTEQGPRCGCHVKFVLHTDGKTC 236
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Calcium-binding EGF-like domain;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 52138546     70 DVDECEREDNAGCVHDCVNIPGNYRCTCYDGFhlaHDGHNC 110
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNC 38

Calcium-binding EGF-like domain;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 52138546    357 DVDECSiNKGGCRFG--CINTPGSYQCTCPAGqgrlHWNGKDCT 398
Cdd:smart00179   1 DIDECA-SGNPCQNGgtCVNTVGSYRCECPPG----YTDGRNCE 39

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138546 804 CGGEL-GEFTGYIESPNYPGNYPAGVECVWNINPPPKRKILIVVPEIFLPSEDECG-DVLVMRKNSSPSSITTYETCqTY 881
Cdd:cd00041   1 CGGTLtASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSyDYLEIYDGPSTSSPLLGRFC-GS 79

                        90       100       110
                ....*....|....*....|....*....|....
gi 52138546 882 ERPIAFTARSRKLWINFKTSEANSARGFQIPYVT 915
Cdd:cd00041  80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138546    813 GYIESPNYPGNYPAGVECVWNINPPPKRKILIVVPEIFLPSEDECG-DVLVMRKNSSPSSITTYETCQTYERPIAFTARS 891
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEyDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSS 80

                           90       100
                   ....*....|....*....|..
gi 52138546    892 RKLWINFKTSEANSARGFQIPY 913
Cdd:smart00042  81 NSLTLTFVSDSSVQKRGFSARY 102

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 52138546   752 GHYYNTSIHRCIRCAVGSYQPDFRQNFCTRCPGNTSTDFDGSTSVAQC 799
Cdd:pfam07699   1 GTYSNTGLEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 52138546   642 GTYYHGQTEQCVPCPAGTFQEREGQLSCDLCPGSDAHGPLGATNVTTC 689
Cdd:pfam07699   1 GTYSNTGLEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 52138546   281 CRLNNGGCDHICRNTVGSFECSCKKGYKLLINERSC 316
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 52138546   201 CNYGNGGCQHTCDDTEQGPRCGCHVKFVLHTDGKTC 236
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 52138546    318 DIDECSFDRTCDH--MCVNTPGSFQCLCHRGY 347
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGY 32

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                        10        20        30
                ....*....|....*....|....*....|....*...
gi 52138546 313 ERSCQDIDECS-FDRTCDHMCVNTPGSFQCLCHRGYLL 349
Cdd:cd01475 181 GKICVVPDLCAtLSHVCQQVCISTPGSYLCACTEGYAL 218

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 52138546  29 DVDECVEGtDNCHIDAICQNTPRSYKCICKSGYTgdGKHCK 69
Cdd:cd00054   1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYT--GRNCE 38

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 52138546   161 CMNKNHGCAHICRETPkGGIACECRPGFELTKNQRDC 197
Cdd:pfam14670   1 CSVNNGGCSHLCLNTP-GGYTCSCPEGYELQDDGRTC 36

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 52138546    112 DVDECAEGNG-GCQQSCVNMMGSYECHCRDGF 142
Cdd:smart00179   1 DIDECASGNPcQNGGTCVNTVGSYRCECPPGY 32

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 52138546   361 CSINKGGCRFGCINTPGSYQCTCPAGQgRLHWNGKDC 397
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGY-ELQDDGRTC 36

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.

                          10        20
                  ....*....|....*....|..
gi 52138546    94 RCTCYDGFHLAHDGHNCLDVDE 115
Cdd:pfam12662   1 TCSCPPGYQLDPDGRTCVDIDE 22

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138546 804 CGGEL-GEFTGYIESPNYPGNYPAGVECVWNINPPPKRKILIVVPEIFLPSEDECG-DVLVMRKNSSPSSITTYETCqTY 881
Cdd:cd00041   1 CGGTLtASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSyDYLEIYDGPSTSSPLLGRFC-GS 79

                        90       100       110
                ....*....|....*....|....*....|....
gi 52138546 882 ERPIAFTARSRKLWINFKTSEANSARGFQIPYVT 915
Cdd:cd00041  80 TLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52138546    813 GYIESPNYPGNYPAGVECVWNINPPPKRKILIVVPEIFLPSEDECG-DVLVMRKNSSPSSITTYETCQTYERPIAFTARS 891
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEyDYVEIYDGPSASSPLLGRFCGSEAPPPVISSSS 80

                           90       100
                   ....*....|....*....|..
gi 52138546    892 RKLWINFKTSEANSARGFQIPY 913
Cdd:smart00042  81 NSLTLTFVSDSSVQKRGFSARY 102

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 52138546   752 GHYYNTSIHRCIRCAVGSYQPDFRQNFCTRCPGNTSTDFDGSTSVAQC 799
Cdd:pfam07699   1 GTYSNTGLEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48

Tyrosine-protein kinase ephrin type A/B receptor-like; This family has repeats of a region rich in cysteines. It is found in various ephrin type A and B receptors, which have tyrosine kinase activity.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 52138546   642 GTYYHGQTEQCVPCPAGTFQEREGQLSCDLCPGSDAHGPLGATNVTTC 689
Cdd:pfam07699   1 GTYSNTGLEPCIPCPRGTYQPEEGQLSCLACPLGTTTDSPGATSISDC 48

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 52138546   281 CRLNNGGCDHICRNTVGSFECSCKKGYKLLINERSC 316
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Calcium-binding EGF domain;

                          10        20        30
                  ....*....|....*....|....*....|..
gi 52138546    29 DVDECVEGTDNCHIDAICQNTPRSYKCICKSG 60
Cdd:pfam07645   1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 52138546     29 DVDECVEGtDNCHIDAICQNTPRSYKCICKSGYTgDGKHCK 69
Cdd:smart00179   1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNCE 39

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 52138546 110 CLDVDECAEGNGGCQQSCVNMMGSYECHCRDGFFLSDNQHT 150
Cdd:cd01475 184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224

Calcium-binding EGF-like domain;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 52138546     70 DVDECEREDNAGCVHDCVNIPGNYRCTCYDGFhlaHDGHNC 110
Cdd:smart00179   1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNC 38

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 52138546 273 KTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERS 315
Cdd:cd01475 182 KICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224

Calcium-binding EGF-like domain;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 52138546    357 DVDECSiNKGGCRFG--CINTPGSYQCTCPAGqgrlHWNGKDCT 398
Cdd:smart00179   1 DIDECA-SGNPCQNGgtCVNTVGSYRCECPPG----YTDGRNCE 39

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                        10        20        30
                ....*....|....*....|....*....|..
gi 52138546 318 DIDECSFDRTCDHM--CVNTPGSFQCLCHRGY 347
Cdd:cd00054   1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGY 32

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 52138546    277 DIDECRLNNG-GCDHICRNTVGSFECSCKKGY 307
Cdd:smart00179   1 DIDECASGNPcQNGGTCVNTVGSYRCECPPGY 32

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.

                          10        20
                  ....*....|....*....|..
gi 52138546   259 HCSCPVGFMLQPDRKTCKDIDE 280
Cdd:pfam12662   1 TCSCPPGYQLDPDGRTCVDIDE 22

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                        10        20        30
                ....*....|....*....|....*....|....*.
gi 52138546  70 DVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAH 105
Cdd:cd00054   1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                        10        20        30
                ....*....|....*....|....*....|..
gi 52138546 112 DVDECAEGNG-GCQQSCVNMMGSYECHCRDGF 142
Cdd:cd00054   1 DIDECASGNPcQNGGTCVNTVGSYRCSCPPGY 32

Calcium-binding EGF domain;

                          10        20        30
                  ....*....|....*....|....*....|..
gi 52138546   112 DVDECAEGNGGCQQS--CVNMMGSYECHCRDG 141
Cdd:pfam07645   1 DVDECATGTHNCPANtvCVNTIGSFECRCPDG 32

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 52138546  52 SYKCICKSGYTGDGKHCKDVDECEREDNaGCVHDCVNIPGNYRCTCYDGFHLAHDG 107
Cdd:cd01475 168 DFSTIEELTKKFQGKICVVPDLCATLSH-VCQQVCISTPGSYLCACTEGYALLEDN 222