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Conserved domains on  [gi|62243248|ref|NP_001013416|]
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insulin-like growth factor-binding protein 3 isoform a precursor [Homo sapiens]

Protein Classification

insulin-like growth factor-binding protein( domain architecture ID 11254546)

insulin-like growth factor-binding protein (IGFBP) controls the bioavailability, activity, and distribution of insulin-like growth factor (IGF) through high-affinity IGFBP/IGF complexes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 38-115 5.16e-30

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


:

Pssm-ID: 197525  Cd Length: 75  Bit Score: 108.32  E-value: 5.16e-30
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62243248     38 VRCEPCDAralAQCAPPPAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCV 115
Cdd:smart00121   1 ARCPPCDP---ARCPPCPPGCAELVRLDGCGCCPVCARQEGEPCGVYTPRCAPGLRCQPPPGEERPLRALLHGQGVCM 75
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 219-291 4.59e-19

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


:

Pssm-ID: 459665  Cd Length: 66  Bit Score: 79.27  E-value: 4.59e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62243248   219 CRREMEDTLNHLKflNVLSPRGVHIPNCDKKGFYKKKQCRPSkgrkRGFCWCVDKYGQPLPGYTTKGKeDVHC 291
Cdd:pfam00086   1 CERERARALEQAA--SGRPASGLYIPNCDEDGFYKPVQCHGS----TGYCWCVDPEGQEIPGTRTRGG-DPDC 66
 
Name Accession Description Interval E-value
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 38-115 5.16e-30

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 108.32  E-value: 5.16e-30
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62243248     38 VRCEPCDAralAQCAPPPAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCV 115
Cdd:smart00121   1 ARCPPCDP---ARCPPCPPGCAELVRLDGCGCCPVCARQEGEPCGVYTPRCAPGLRCQPPPGEERPLRALLHGQGVCM 75
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 219-291 4.59e-19

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 79.27  E-value: 4.59e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62243248   219 CRREMEDTLNHLKflNVLSPRGVHIPNCDKKGFYKKKQCRPSkgrkRGFCWCVDKYGQPLPGYTTKGKeDVHC 291
Cdd:pfam00086   1 CERERARALEQAA--SGRPASGLYIPNCDEDGFYKPVQCHGS----TGYCWCVDPEGQEIPGTRTRGG-DPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 218-291 1.20e-16

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 72.88  E-value: 1.20e-16
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62243248 218 PCRREMEDTLNHLKflnVLSPRGVHIPNCDKKGFYKKKQCRPSKgrkrGFCWCVDKYGQPLPGYTTKGkEDVHC 291
Cdd:cd00191   1 PCERERASALESLA---GPKLSGLYVPQCDEDGNYEPVQCHGST----GYCWCVDPDGEEIPGTRTRG-GPPNC 66
IGFBP pfam00219
Insulin-like growth factor binding protein;
41-94 4.37e-16

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 70.82  E-value: 4.37e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 62243248    41 EPCDARalaQCAPPPAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRC 94
Cdd:pfam00219   3 PPCDPE---RCPPPPPGCPAGVVLDGCGCCKVCARQEGEPCGVYTPPCGKGLRC 53
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 243-293 9.43e-12

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 58.93  E-value: 9.43e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 62243248    243 IPNCDKKGFYKKKQCRPSkgrkRGFCWCVDKYGQPLPGyTTKGKEDVHCYS 293
Cdd:smart00211   1 IPQCDEDGNYEPVQCDGS----SGQCWCVDATGREIPG-TRTEGGDPDCPS 46
 
Name Accession Description Interval E-value
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 38-115 5.16e-30

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 108.32  E-value: 5.16e-30
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62243248     38 VRCEPCDAralAQCAPPPAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSPDEARPLQALLDGRGLCV 115
Cdd:smart00121   1 ARCPPCDP---ARCPPCPPGCAELVRLDGCGCCPVCARQEGEPCGVYTPRCAPGLRCQPPPGEERPLRALLHGQGVCM 75
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 219-291 4.59e-19

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 79.27  E-value: 4.59e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62243248   219 CRREMEDTLNHLKflNVLSPRGVHIPNCDKKGFYKKKQCRPSkgrkRGFCWCVDKYGQPLPGYTTKGKeDVHC 291
Cdd:pfam00086   1 CERERARALEQAA--SGRPASGLYIPNCDEDGFYKPVQCHGS----TGYCWCVDPEGQEIPGTRTRGG-DPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 218-291 1.20e-16

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 72.88  E-value: 1.20e-16
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62243248 218 PCRREMEDTLNHLKflnVLSPRGVHIPNCDKKGFYKKKQCRPSKgrkrGFCWCVDKYGQPLPGYTTKGkEDVHC 291
Cdd:cd00191   1 PCERERASALESLA---GPKLSGLYVPQCDEDGNYEPVQCHGST----GYCWCVDPDGEEIPGTRTRG-GPPNC 66
IGFBP pfam00219
Insulin-like growth factor binding protein;
41-94 4.37e-16

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 70.82  E-value: 4.37e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 62243248    41 EPCDARalaQCAPPPAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRC 94
Cdd:pfam00219   3 PPCDPE---RCPPPPPGCPAGVVLDGCGCCKVCARQEGEPCGVYTPPCGKGLRC 53
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 243-293 9.43e-12

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 58.93  E-value: 9.43e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 62243248    243 IPNCDKKGFYKKKQCRPSkgrkRGFCWCVDKYGQPLPGyTTKGKEDVHCYS 293
Cdd:smart00211   1 IPQCDEDGNYEPVQCDGS----SGQCWCVDATGREIPG-TRTEGGDPDCPS 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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