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Conserved domains on  [gi|62473489|ref|NP_001014723|]
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proctolin receptor, isoform D [Drosophila melanogaster]

Protein Classification

G-protein coupled receptor( domain architecture ID 11606548)

G-protein coupled receptor (GPCR) transmits physiological signals from the outside of the cell to the inside by binding to an extracellular agonist, which induces conformational changes that lead to the activation of heterotrimeric G proteins, which then bind to and activate numerous downstream effector proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
41-488 8.79e-59

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


:

Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 197.47  E-value: 8.79e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  41 VVQRILVPCVFVIGLLGNSVSIYVLTRKRMRCTTNIYLTALAITDIAYLTCQLILSLQHYDYPKYH---FKLYWQLYGYF 117
Cdd:cd14978   1 VLYGYVLPVICIFGIIGNILNLVVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSsflSYFYAYFLPYI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 118 VWLCDSFGYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAFEHTITigtrqiddayqpcn 197
Cdd:cd14978  81 YPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVV-------------- 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 198 qtvanispmppppvavtpplatpplptpatiwqspdsamesttsgssnqlvdwgsgsgdgepeniprhrrhwqssgfvtl 277
Cdd:cd14978     --------------------------------------------------------------------------------
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 278 ptlrktleeqdqkvadaaqrsgvtesllqlwrrkrsaENHNINNTDAFAFNVTEYCQNVTYYnhglselgydeLYSYLWn 357
Cdd:cd14978 147 -------------------------------------ECENCNNNSYYYVIPTLLRQNETYL-----------LKYYFW- 177
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 358 lFTLLVFVVFPLLLLATFNSILILLVHRSKNlrgdltnassIRRTKRKSNSGLKGSVSQENRVTITLIAVVLMFIVCQLP 437
Cdd:cd14978 178 -LYAIFVVLLPFILLLILNILLIRALRKSKK----------RRRLLRRRRRLLSRSQRRERRTTIMLIAVVIVFLICNLP 246
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|...
gi 62473489 438 WAIYLIVNQYMEI--QIGTQVVAGNVCNLLASLHAASNFFLYCVLSDKYRKTV 488
Cdd:cd14978 247 AGILNILEAIFGEsfLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
 
Name Accession Description Interval E-value
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
41-488 8.79e-59

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 197.47  E-value: 8.79e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  41 VVQRILVPCVFVIGLLGNSVSIYVLTRKRMRCTTNIYLTALAITDIAYLTCQLILSLQHYDYPKYH---FKLYWQLYGYF 117
Cdd:cd14978   1 VLYGYVLPVICIFGIIGNILNLVVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSsflSYFYAYFLPYI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 118 VWLCDSFGYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAFEHTITigtrqiddayqpcn 197
Cdd:cd14978  81 YPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVV-------------- 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 198 qtvanispmppppvavtpplatpplptpatiwqspdsamesttsgssnqlvdwgsgsgdgepeniprhrrhwqssgfvtl 277
Cdd:cd14978     --------------------------------------------------------------------------------
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 278 ptlrktleeqdqkvadaaqrsgvtesllqlwrrkrsaENHNINNTDAFAFNVTEYCQNVTYYnhglselgydeLYSYLWn 357
Cdd:cd14978 147 -------------------------------------ECENCNNNSYYYVIPTLLRQNETYL-----------LKYYFW- 177
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 358 lFTLLVFVVFPLLLLATFNSILILLVHRSKNlrgdltnassIRRTKRKSNSGLKGSVSQENRVTITLIAVVLMFIVCQLP 437
Cdd:cd14978 178 -LYAIFVVLLPFILLLILNILLIRALRKSKK----------RRRLLRRRRRLLSRSQRRERRTTIMLIAVVIVFLICNLP 246
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|...
gi 62473489 438 WAIYLIVNQYMEI--QIGTQVVAGNVCNLLASLHAASNFFLYCVLSDKYRKTV 488
Cdd:cd14978 247 AGILNILEAIFGEsfLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
57-174 2.08e-13

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 70.40  E-value: 2.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489    57 GNSVSIYVLTR-KRMRCTTNIYLTALAITDIAYLTCQLILSLQHYDYPKYhfklyWQLyGYFvwLCDSFGYI-------S 128
Cdd:pfam00001   1 GNLLVILVILRnKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGD-----WPF-GSA--LCKIVGALfvvngyaS 72
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 62473489   129 IYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTL 174
Cdd:pfam00001  73 ILLLTAISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSL 118
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
44-202 1.23e-06

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 50.78  E-value: 1.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489   44 RILVPCVFVIGLLGNSVSIYVLTRKRMRCTTNIYLTALAITDIAYLTcqlilslqhyDYPKYHFKLYWQ-LYGYFVWLCD 122
Cdd:PHA02638 102 KIFYIIIFILGLFGNAAIIMILFCKKIKTITDIYIFNLAISDLIFVI----------DFPFIIYNEFDQwIFGDFMCKVI 171
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  123 SFGYI-----SIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLST--AFEHTITIGTRqiddayQP 195
Cdd:PHA02638 172 SASYYigffsNMFLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPAyfIFEASNIIFSA------QD 245

                 ....*..
gi 62473489  196 CNQTVAN 202
Cdd:PHA02638 246 SNETISN 252
 
Name Accession Description Interval E-value
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
41-488 8.79e-59

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 197.47  E-value: 8.79e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  41 VVQRILVPCVFVIGLLGNSVSIYVLTRKRMRCTTNIYLTALAITDIAYLTCQLILSLQHYDYPKYH---FKLYWQLYGYF 117
Cdd:cd14978   1 VLYGYVLPVICIFGIIGNILNLVVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSsflSYFYAYFLPYI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 118 VWLCDSFGYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAFEHTITigtrqiddayqpcn 197
Cdd:cd14978  81 YPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVV-------------- 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 198 qtvanispmppppvavtpplatpplptpatiwqspdsamesttsgssnqlvdwgsgsgdgepeniprhrrhwqssgfvtl 277
Cdd:cd14978     --------------------------------------------------------------------------------
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 278 ptlrktleeqdqkvadaaqrsgvtesllqlwrrkrsaENHNINNTDAFAFNVTEYCQNVTYYnhglselgydeLYSYLWn 357
Cdd:cd14978 147 -------------------------------------ECENCNNNSYYYVIPTLLRQNETYL-----------LKYYFW- 177
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 358 lFTLLVFVVFPLLLLATFNSILILLVHRSKNlrgdltnassIRRTKRKSNSGLKGSVSQENRVTITLIAVVLMFIVCQLP 437
Cdd:cd14978 178 -LYAIFVVLLPFILLLILNILLIRALRKSKK----------RRRLLRRRRRLLSRSQRRERRTTIMLIAVVIVFLICNLP 246
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|...
gi 62473489 438 WAIYLIVNQYMEI--QIGTQVVAGNVCNLLASLHAASNFFLYCVLSDKYRKTV 488
Cdd:cd14978 247 AGILNILEAIFGEsfLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
45-481 2.20e-19

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 88.11  E-value: 2.20e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCVFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIAYLTCQLILSLQHYDYPKYHF-KLYWQLYGYfvwLCD 122
Cdd:cd00637   3 VLYILIFVVGLVGNLLVILVILRnRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFgDALCKLLGF---LQS 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 123 SFGYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLstlstafehtitigtrqiddayqpcnqtvan 202
Cdd:cd00637  80 VSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLL------------------------------- 128
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 203 ispmppppvavtpplatpplptpatiwqspdsamesttsgssnqlvdwgsgsgdgepeniprhrrhwqssgfVTLPTLrk 282
Cdd:cd00637 129 ------------------------------------------------------------------------LALPPL-- 134
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 283 tleeqdqkvadaaqrsgvtesllqlwrrkrsaenhninntdaFAFNVTEYcqnvtYYNHGLSELGYDELYSYLWNLFTLL 362
Cdd:cd00637 135 ------------------------------------------LGWGVYDY-----GGYCCCCLCWPDLTLSKAYTIFLFV 167
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 363 VFVVFPLLLLATFNS-ILILLVHRSKNLRGDLTNASSIRRTKRksnsglkgsvsqENRVTITLIAVVLMFIVCQLPWAIY 441
Cdd:cd00637 168 LLFLLPLLVIIVCYVrIFRKLRRHRRRIRSSSSNSSRRRRRRR------------ERKVTKTLLIVVVVFLLCWLPYFIL 235
                       410       420       430       440
                ....*....|....*....|....*....|....*....|
gi 62473489 442 LIVNQYMEIQIGTQVVAGNVCNLLASLHAASNFFLYCVLS 481
Cdd:cd00637 236 LLLDVFGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
50-178 3.01e-17

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 81.94  E-value: 3.01e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIayLTCQLILSLQHYdypkYHFKLYWQLYG---YFVWLcdsFG 125
Cdd:cd15001   9 TFVLGLIGNSLVIFVVARfRRMRSVTNVFLASLATADL--LLLVFCVPLKTA----EYFSPTWSLGAflcKAVAY---LQ 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62473489 126 YISIYIAV----CFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAF 178
Cdd:cd15001  80 LLSFICSVltltAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLF 136
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
41-171 1.52e-15

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 77.04  E-value: 1.52e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  41 VVQRILVPCVFVIGLLGNS-VSIYVLTRKRMRCTTNIYLTALAITDIAYLTCQLILSLQHYDYPKYHFklywqLYGYFVW 119
Cdd:cd14995   1 VVATFLVLLICGVGIVGNImVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAAGLPNEIESLLGPDSW-----IYGYAGC 75
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62473489 120 LCDSF-GYISIYIAVC----FTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLL 171
Cdd:cd14995  76 LLITYlQYLGINASSLsitaFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSL 132
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
49-182 4.44e-15

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 75.85  E-value: 4.44e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  49 CVFVIGLLGNSVSIYVLTRKR-MRCTTNIYLTALAITDIAYLTCQLILSL--QHYDYPKYHFKLYWQLYgYFvwLCDSFG 125
Cdd:cd14979   9 AIFVVGIVGNLLTCIVIARHKsLRTTTNYYLFSLAVSDLLILLVGLPVELynFWWQYPWAFGDGGCKLY-YF--LFEACT 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62473489 126 YISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAFEHTI 182
Cdd:cd14979  86 YATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGI 142
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
45-197 2.19e-14

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 73.48  E-value: 2.19e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCVF----VIGLLGNSVSIYV-LTRKRMRCTTNIYLTALAITDIAYLTcqLILSLQHYDY--PKYHFKLYW-QLYGY 116
Cdd:cd15096   1 IVVPVIFglifIVGLIGNSLVILVvLSNQQMRSTTNILILNLAVADLLFVV--FCVPFTATDYvlPTWPFGDVWcKIVQY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 117 FVWLCdsfGYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAFEHTITIGTrQIDDAYQPC 196
Cdd:cd15096  79 LVYVT---AYASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLFLHGVVSYG-FSSEAYSYC 154

                .
gi 62473489 197 N 197
Cdd:cd15096 155 T 155
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
57-174 2.08e-13

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 70.40  E-value: 2.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489    57 GNSVSIYVLTR-KRMRCTTNIYLTALAITDIAYLTCQLILSLQHYDYPKYhfklyWQLyGYFvwLCDSFGYI-------S 128
Cdd:pfam00001   1 GNLLVILVILRnKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGD-----WPF-GSA--LCKIVGALfvvngyaS 72
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 62473489   129 IYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTL 174
Cdd:pfam00001  73 ILLLTAISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSL 118
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
50-182 2.46e-13

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 70.82  E-value: 2.46e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTRKR-MRCTTNIYLTALAITDIAYLtcqlILSLqhydypKYHFKLYWQLYGYF---------VW 119
Cdd:cd15134  10 IFVTGVVGNLCTCIVIARNRsMHTATNYYLFSLAVSDLLLL----ILGL------PFELYTIWQQYPWVfgevfcklrAF 79
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62473489 120 LCDSFGYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAFEHTI 182
Cdd:cd15134  80 LSEMSSYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPFAIQTRI 142
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
49-180 2.78e-13

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 70.37  E-value: 2.78e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  49 CVFVIGLLGNSVSIYVLTRK-RMRCTTNIYLTALAITDIAYLTCqliLSLQHYdypkYHFKLYWQLYGYFvwLCDSFG-- 125
Cdd:cd14982   9 LIFILGLLGNILALWVFLRKmKKRSPTTIYMINLALADLLFVLT---LPFRIY----YYLNGGWWPFGDF--LCRLTGll 79
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 126 -YISIYIAVCF----TIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAFEH 180
Cdd:cd14982  80 fYINMYGSILFltciSVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLR 139
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
50-165 6.33e-13

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 69.55  E-value: 6.33e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIAY-LTCQLILSLQHYdypkyhFKLYWqlYGYFvwLCDSFGYI 127
Cdd:cd14993  10 VFLLALVGNSLVIAVVLRnKHMRTVTNYFLVNLAVADLLVsLFCMPLTLLENV------YRPWV--FGEV--LCKAVPYL 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 62473489 128 -------SIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAV 165
Cdd:cd14993  80 qgvsvsaSVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAI 124
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
49-178 4.72e-12

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 66.74  E-value: 4.72e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  49 CVFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIAYLTCqliLSLQHYDYPKYHFKLYWQLYGYFV-WLCDSFGY 126
Cdd:cd15132   9 ILFVVGVTGNTMTVLIIRRyKDMRTTTNLYLSSMAVSDLLILLC---LPFDLYRLWKSRPWIFGEFLCRLYhYISEGCTY 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 62473489 127 ISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAF 178
Cdd:cd15132  86 ATILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALLSAGPFLF 137
7TM_GPCR_Srw pfam10324
Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis ...
52-183 6.55e-11

Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srw is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srw do not appear to be under as strong an adaptive evolutionary pressure as those of Srz.


Pssm-ID: 402097  Cd Length: 318  Bit Score: 63.76  E-value: 6.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489    52 VIGLLGNSVSIYVLTRKRMR-CTTNIYLTALAITDIAYLTCQLILSLQHYDY---------PKYHFKLYwqLYGYFVWLC 121
Cdd:pfam10324   8 FIGFIINIFHLIILTRKSMRtSSINIIMIGIAICDIITMLLTIYNFIPEFIIsyensecipPDSYLKVL--LDWILESLQ 85
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62473489   122 DSFGYISIYIAVCFTIERFIAIRYPL--KRQTFCTESLAKKVIAAVAIFCLLSTLSTAFEHTIT 183
Cdd:pfam10324  86 DYSRRCSTWLGVFMALIRTLVVKNPMsnKIQKLSKPKFGLIIIIIVFILSLPISIFYYFRYEIV 149
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
45-185 7.35e-11

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 63.07  E-value: 7.35e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCVFVI----GLLGNSVSIYVLTRKR-MRCTTNIYLTALAITDIAYLTCQLILSLQHYDYPKYHFKLywqlygyfvW 119
Cdd:cd15095   1 WLVPLIFAIiflvGLAGNSLVIYVVSRHReMRTVTNYYIVNLAVTDLAFLVCCVPFTAALYATPSWVFGD---------F 71
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62473489 120 LCDSFGYISIYI--AVCFT-----IERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAFEHTITIG 185
Cdd:cd15095  72 MCKFVNYMMQVTvqATCLTltalsVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLEEG 144
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
50-200 7.53e-11

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 62.87  E-value: 7.53e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIAYLTCQLILSLQHYDYPKYHFKLYW-QLYGYFVWLCdsfGYI 127
Cdd:cd14971  10 IFLLGLVGNSLVILVVARnKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMcKFVHYFQQVS---MHA 86
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62473489 128 SIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAFEHTITigtrqiddAYQPCNQTV 200
Cdd:cd14971  87 SIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLR--------NYTPGNRTV 151
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
45-172 7.83e-10

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 60.28  E-value: 7.83e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCV--FVIGLLGNSVSIYVLTRKR-MRCTTNIYLTALAITDIAYLTCQLILSLQHYDYPKYHF-KLYWQLygyFVWL 120
Cdd:cd15131   3 ITVTCVllFVVGVTGNLMTMLVVSKYRdMRTTTNLYLSSMAFSDLLIFLCMPLDLYRLWQYRPWNFgDLLCKL---FQFV 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 62473489 121 CDSFGYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLS 172
Cdd:cd15131  80 SESCTYSTILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLS 131
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
50-178 9.11e-10

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 60.00  E-value: 9.11e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGN-SVSIYVLTRKRMRCTTNIYLTALAITDIAYLTCQLILSLQhydypKYHFKLYWQLyGYFvwLCDSFGYIS 128
Cdd:cd14997  10 IFVVGVLGNvLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALV-----ETWAREPWLL-GEF--MCKLVPFVE 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62473489 129 IYIA-------VCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAF 178
Cdd:cd14997  82 LTVAhasvltiLAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLF 138
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
42-176 1.33e-09

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 59.27  E-value: 1.33e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  42 VQRILVPCVFVIGLLGNSVSIYVLTRKRMRCT-TNIYLTALAITDIAyltcqLILSLQhydYPKYHFKLYWQLYGYFVWL 120
Cdd:cd15165   2 LQLVVYIPTFVLGLLLNLMALWVFLFKIKKWTeSTIYMINLALNDLL-----LLLSLP---FKMHSSKKQWPLGRTLCSF 73
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 121 CDSFGYI----SIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLST 176
Cdd:cd15165  74 LESLYFVnmygSILIIVCISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSIPI 133
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
50-173 1.39e-09

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 59.37  E-value: 1.39e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDiayLTCQLILSLQHYDYPKyhfKLYWqLYGYFVWLCDSFG--- 125
Cdd:cd15158  10 ITVFGLVGNGFALYVLIKtYRQKSAFHIYMLNLAVSD---LLCVCTLPLRVVYYVH---KGQW-LFGDFLCRISSYAlyv 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 62473489 126 --YISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLST 173
Cdd:cd15158  83 nlYCSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTS 132
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
49-172 1.44e-09

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 59.43  E-value: 1.44e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  49 CVFVIGLLGNSVSIYVLTRKR-MRCTTNIYLTALAITDIAYLTCQLILSLQHYDYPKYHF-KLYWQLYGYFvwlCDSFGY 126
Cdd:cd15928   9 VLMLVGASGNLLTVLVIGRSRdMRTTTNLYLSSLAVSDLLIFLVLPLDLYRLWRYRPWRFgDLLCRLMYFF---SETCTY 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 62473489 127 ISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLS 172
Cdd:cd15928  86 ASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVS 131
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
50-174 2.54e-09

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 58.38  E-value: 2.54e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIayLTCQLILSLQhydyPKYHFKLYWQLYGyfvWLCDSFGY-- 126
Cdd:cd15203  10 IIVLGVVGNLLVIYVVLRnKSMQTVTNIFILNLAVSDL--LLCLVSLPFT----LIYTLTKNWPFGS---ILCKLVPSlq 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 62473489 127 -ISIYIaVCFT-----IERFIAIRYPLKRQTFCTesLAKKVIAAVAIFCLLSTL 174
Cdd:cd15203  81 gVSIFV-STLTltaiaIDRYQLIVYPTRPRMSKR--HALLIIALIWILSLLLSL 131
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
50-193 3.16e-09

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 58.14  E-value: 3.16e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIY-VLTRKRMRCTTNIYLTALAITDIAY-LTCQLILSLQHYDYpkyhfkLYWqLYGYFvwLCDSFGYI 127
Cdd:cd15392  10 IFVLAVGGNGLVCYiVVSYPRMRTVTNYFIVNLALSDILMaVFCVPFSFIALLIL------QYW-PFGEF--MCPVVNYL 80
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62473489 128 -------SIYIAVCFTIERFIAIRYPLKRQTfcTESLAKKVIAAVAIFCLLSTLSTAFEHTITIGTRQIDDAY 193
Cdd:cd15392  81 qavsvfvSAFTLVAISIDRYVAIMWPLRPRM--TKRQALLLIAVIWIFALATALPIAITSRLFEDSNASCGQY 151
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
50-182 3.17e-09

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 58.24  E-value: 3.17e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTRKR-MRCTTNIYLTALAITDIAYLTCQLILSLqhYD-YPKYHFkLYWQLYGYF-VWLCDSFGY 126
Cdd:cd15358  10 IFVVGAVGNGLTCIVILRHKvMRTPTNYYLFSLAVSDLLVLLLGMPLEL--YEmWSNYPF-LLGAGGCYFkTLLFETVCF 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 62473489 127 ISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAFEHTI 182
Cdd:cd15358  87 ASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIPNTSLHGI 142
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
45-171 4.50e-09

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 57.60  E-value: 4.50e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCVFVIGLLGNSVSIYVLTRKR-MRCTTNIYLTALAITDIAYLTCQLILSLqhydYPKYHFKLYW-----QLYGYFV 118
Cdd:cd14969   5 VYLSLIGVLGVVLNGLVIIVFLKKKkLRTPLNLFLLNLALADLLMSVVGYPLSF----YSNLSGRWSFgdpgcVIYGFAV 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 62473489 119 WLcdsFGYISIYIAVCFTIERFIAIRYPLKRQTFcTESLAKKVIAAVAIFCLL 171
Cdd:cd14969  81 TF---LGLVSISTLAALAFERYLVIVRPLKAFRL-SKRRALILIAFIWLYGLF 129
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
45-178 6.22e-09

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 57.34  E-value: 6.22e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCVFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDiaYLTCQLILSLQHYD--YPKYHF-KLYWQLYGYFVWL 120
Cdd:cd15083   5 IFILIIGLIGVVGNGLVIYAFCRfKSLRTPANYLIINLAISD--FLMCILNCPLMVISsfSGRWIFgKTGCDMYGFSGGL 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 62473489 121 cdsFGYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAF 178
Cdd:cd15083  83 ---FGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLF 137
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
50-188 6.70e-09

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 57.33  E-value: 6.70e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIY-VLTRKRMRCTTNIYLTALAITDIAYLtCQLILsLQHYDYPKYH------------FKLYWQLYGy 116
Cdd:cd15168  10 VFLVGLLLNSVVLYrFIFHLKPWNSSAIYMFNLAVSDLLYL-LSLPF-LIYYYANGDHwifgdfmcklvrFLFYFNLYG- 86
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62473489 117 fvwlcdsfgyiSIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTA-FEHTITIGTRQ 188
Cdd:cd15168  87 -----------SILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILfFATTGRKNNRT 148
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
50-171 7.09e-09

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 57.02  E-value: 7.09e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIayLTCQLILSlqhydypkyhFKLYWQLYGYFVW---LCDSFG 125
Cdd:cd15206  10 IFLLAVVGNILVIVTLVQnKRMRTVTNVFLLNLAVSDL--LLAVFCMP----------FTLVGQLLRNFIFgevMCKLIP 77
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 62473489 126 Y-------ISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLL 171
Cdd:cd15206  78 YfqavsvsVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFL 130
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
50-184 8.30e-09

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 56.85  E-value: 8.30e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLT-RKRMRCTTNIYLTALAITDIAYLtCQLILSLqhydypKYHFKLYWQlygYFVWLCDSFG--- 125
Cdd:cd15155  10 VFILGLITNCASLFVFCfRMKMRNETAIFMTNLAVSDLLFV-FTLPFKI------FYNFNRHWP---FGDSLCKISGtaf 79
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62473489 126 ----YISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAFEHTITI 184
Cdd:cd15155  80 ltniYGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNV 142
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
50-174 1.09e-08

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 56.53  E-value: 1.09e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTRK-RMRCTTNIYLTALAITDIAYLtcqLILSLQHYDYpkyhFKLYW---QLYGYFVWLCDSF- 124
Cdd:cd14970  10 VCVVGLTGNSLVIYVILRYsKMKTVTNIYILNLAVADELFL---LGLPFLATSY----LLGYWpfgEVMCKIVLSVDAYn 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 62473489 125 GYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTL 174
Cdd:cd14970  83 MFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGL 132
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
45-197 1.31e-08

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 56.32  E-value: 1.31e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCVF----VIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITD------IAYLTCQLILSlqHYDYPKYHFKLYWQL 113
Cdd:cd15093   1 VLIPCIYavvcLVGLCGNSLVIYVVLRyAKMKTVTNIYILNLAIADelfmlgLPFLAASNALR--HWPFGSVLCRLVLSV 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 114 YGYFVwlcdsfgYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAfehtITIGTRQIDDAY 193
Cdd:cd15093  79 DGINM-------FTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVV----VFAGTRENQDGS 147

                ....
gi 62473489 194 QPCN 197
Cdd:cd15093 148 SACN 151
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
45-184 1.81e-08

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 56.12  E-value: 1.81e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCVFVIGLLGNSVSIYVLTRKR-MRCTTNIYLTALAITDIAYLTCQLILSLQHYDYPKYhfklywqLYGYFvwLCDS 123
Cdd:cd15927   5 ILFALIFLVGVLGNGTLILIFLRNKsMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDSW-------PFGEF--LCKL 75
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62473489 124 FGYI---SIYIAVcFT-----IERFIAIRYPLKRQTfcTESLAKKVIAAVAIF---CLLSTLSTAFEHTITI 184
Cdd:cd15927  76 SEFLkdtSIGVSV-FTltalsADRYFAIVNPMRKHR--SQATRRTLVTAASIWivsILLAIPEAIFSHVVTF 144
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
50-175 3.06e-08

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 55.05  E-value: 3.06e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTRKRMRC-TTNIYLTALAITDIAY---LTCQLILSLQHYDYPkyhfklywqlygYFVWLCDSFG 125
Cdd:cd15159  10 ILVFGLLGNTLALHVICQKRKKInSTTLYLINLAVSDILFtlaLPGRIAYYALGFDWP------------FGDWLCRLTA 77
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62473489 126 -------YISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLS 175
Cdd:cd15159  78 llfyintYAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLP 134
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
50-182 4.43e-08

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 54.84  E-value: 4.43e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIAYLTCQLILSL----QHYDYPKYHFKLYWQLYgyfvwLCDSF 124
Cdd:cd15133  10 IFVVGVVGNVLTCLVIARhKAMRTPTNYYLFSLAVSDLLVLLLGMPLELyelwQNYPFLLGSGGCYFKTF-----LFETV 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 62473489 125 GYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAFEHTI 182
Cdd:cd15133  85 CLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALPNTSLHGI 142
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
353-486 5.43e-08

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 54.22  E-value: 5.43e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 353 SYLWNLFTLLVFVVFPLLLLATFNSILILLVHRSKNLRGdlTNASSIRRTKRksnsglkgsvsqenRVTITLIAVVLMFI 432
Cdd:cd14970 162 GRVFTIYTFVLGFAVPLLVITVCYSLIIRRLRSSRNLST--SGAREKRRARR--------------KVTRLVLVVVAVFV 225
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 62473489 433 VCQLPWAIYLIVNQYMEIQIG-TQVVAGNVCNLLASLHAASNFFLYCVLSDKYRK 486
Cdd:cd14970 226 VCWLPFHVFQIVRLLIDPPETlTVVGVFLFCIALSYANSCLNPILYAFLDENFRK 280
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
41-197 6.33e-08

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 54.09  E-value: 6.33e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  41 VVQRILVPCVFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIAYLTCQLILS----LQHYDYPKyhfklywqlyg 115
Cdd:cd15973   1 VVIQFIYALVCLVGLIGNSMVIFVILRyAKMKTATNIYILNLAIADELFMLSVPFLAasaaLQHWPFGS----------- 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 116 yfvWLCDSF-------GYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAfehtITIGTRQ 188
Cdd:cd15973  70 ---AMCRTVlsvdginMFTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPII----IFADTAT 142

                ....*....
gi 62473489 189 IDDAYQPCN 197
Cdd:cd15973 143 RKGQAVACN 151
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
50-182 1.11e-07

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 53.71  E-value: 1.11e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNS-VSIYVLTRKRMRCTTNIYLTALAITDIayLTCQLILSLQHYD-YPKYHFkLYWQLYGYF-VWLCDSFGY 126
Cdd:cd15357  10 IFVVGVIGNLlVCLVILKHQNMKTPTNYYLFSLAVSDL--LVLLFGMPLEVYEmWSNYPF-LFGPVGCYFkTALFETVCF 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 62473489 127 ISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAFEHTI 182
Cdd:cd15357  87 ASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIPNTSIHGI 142
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
42-164 1.14e-07

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 53.34  E-value: 1.14e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  42 VQRILVPCVFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIayLTCQLILSlqhydypkyhFKLYWQLYGYFVW- 119
Cdd:cd15978   2 VRILLYSLIFLLSVLGNSLIIAVLIRnKRMRTVTNIFLLSLAVSDL--MLCLFCMP----------FTLIPNLLKDFIFg 69
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 62473489 120 --LCDSFGY-------ISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAA 164
Cdd:cd15978  70 saVCKTATYfmgisvsVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAA 123
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
50-174 1.15e-07

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 53.38  E-value: 1.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITD-IAYLTCQLILS---LQHYDYPKYHFKLywqlygyfVWLCDSF 124
Cdd:cd15970  10 VCLVGLCGNSMVIYVILRyAKMKTATNIYILNLAIADeLLMLSVPFLVTstlLRHWPFGSLLCRL--------VLSVDAI 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 62473489 125 G-YISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTL 174
Cdd:cd15970  82 NmFTSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVIL 132
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
50-171 1.34e-07

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 53.31  E-value: 1.34e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTRKR----MRCTTNIYLTALAITDIayLTCQLILSLQHYDYPKYHFKlyWQL-----YGYFvWL 120
Cdd:cd15355  10 LFVVGTVGNSITLYTLARKKslqhLQSTVHYHLASLALSDL--LILLLAMPVELYNFIWVHHP--WAFgdaacRGYY-FL 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 62473489 121 CDSFGYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLL 171
Cdd:cd15355  85 RDACTYATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASAL 135
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
45-148 2.37e-07

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 52.46  E-value: 2.37e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPcVFVIGLLGNSVSIYVL-TRKRMRCTTNIYLTALAITDiayltCQLILSLQhydypkyhFKLYW--QLYGYFVWLC 121
Cdd:cd15923   6 IYIP-TFVLGLLLNILALWVFcWRLKKWTETNIYMTNLAVAD-----LLLLISLP--------FKMHSyrRESAGLQKLC 71
                        90       100       110
                ....*....|....*....|....*....|....
gi 62473489 122 DSFG-------YISIYIAVCFTIERFIAIRYPLK 148
Cdd:cd15923  72 NFVLslyyinmYVSIFTITAISVDRYVAIRYPLR 105
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
50-178 4.83e-07

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 51.39  E-value: 4.83e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLT-RKRMRCTTNIYLTALAITDIAYLtcqLILSLQHYDYPKYHFKLYWQLYGYFVWLCDSFGYIS 128
Cdd:cd15156  10 VFVLGLIANCVAIYIFMcTLKVRNETTTYMINLAISDLLFV---FTLPFRIFYFVQRNWPFGDLLCKISVTLFYTNMYGS 86
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 62473489 129 IYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAF 178
Cdd:cd15156  87 ILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLPASF 136
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
50-150 5.06e-07

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 51.25  E-value: 5.06e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTRKR-MRCTTNIYLTALAITDIAYLtcqLILSLQHYdypkYHFK-LYW-------QLYGYFVWL 120
Cdd:cd15161  10 VFILAFPGNTLALWLFIHDRkSGTPSNVFLMHLAVADLSYV---LILPMRLV----YHLSgNHWpfgevpcRLAGFLFYL 82
                        90       100       110
                ....*....|....*....|....*....|
gi 62473489 121 CdsfGYISIYIAVCFTIERFIAIRYPLKRQ 150
Cdd:cd15161  83 N---MYASLYFLACISVDRFLAIVHPVKSM 109
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
51-171 5.78e-07

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 51.09  E-value: 5.78e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  51 FVIGLLGNSVSIYVLTRKRMR-CTTNIYL--TALAITDiayLTCQLILS-LQHYDYPKyHFKlyWQLYGYfvwLCDSFGY 126
Cdd:cd14981  11 FVFGVLGNLLALIVLARSSKShKWSVFYRlvAGLAITD---LLGILLTSpVVLAVYAS-NFE--WDGGQP---LCDYFGF 81
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 62473489 127 I-------SIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLL 171
Cdd:cd14981  82 MmsffglsSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALL 133
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
42-171 1.02e-06

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 50.58  E-value: 1.02e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  42 VQRILVPCVFVIGLLGNSVSIYVLT-RKRMRCTTNIYLTALAITDIAYLTCQLilslqhydypkyHFKLYWQLYGYFVW- 119
Cdd:cd15979   2 VRILLYSVIFLLSVFGNMLIIVVLGlNKRLRTVTNSFLLSLALSDLMLAVFCM------------PFTLIPNLMGTFIFg 69
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62473489 120 --LCDSFGY-------ISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLL 171
Cdd:cd15979  70 evICKAVAYlmgvsvsVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGL 130
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
44-202 1.23e-06

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 50.78  E-value: 1.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489   44 RILVPCVFVIGLLGNSVSIYVLTRKRMRCTTNIYLTALAITDIAYLTcqlilslqhyDYPKYHFKLYWQ-LYGYFVWLCD 122
Cdd:PHA02638 102 KIFYIIIFILGLFGNAAIIMILFCKKIKTITDIYIFNLAISDLIFVI----------DFPFIIYNEFDQwIFGDFMCKVI 171
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  123 SFGYI-----SIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLST--AFEHTITIGTRqiddayQP 195
Cdd:PHA02638 172 SASYYigffsNMFLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPAyfIFEASNIIFSA------QD 245

                 ....*..
gi 62473489  196 CNQTVAN 202
Cdd:PHA02638 246 SNETISN 252
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
50-173 1.23e-06

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 50.19  E-value: 1.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTRK-RMRCTTNIYLTALAITDIaYLTCQLILSLQHY----DYPKYHFKLYWQLYGYFVWLcdsf 124
Cdd:cd15921  10 IFILGLTGNSISVYVFLSQyRSQTPVSVLMVNLAISDL-LLVCTLPLRLTYYvlnsHWPFGDIACRIILYVLYVNM---- 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 62473489 125 gYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLST 173
Cdd:cd15921  85 -YSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLAS 132
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
45-151 1.30e-06

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 50.13  E-value: 1.30e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCVFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIaYLTCQLILSLQHYDYpkyhfKLYWqLYG----YFVW 119
Cdd:cd15384   5 VVLAVMFVISFIGNLLTIIQIYRlRRSRRTIYSLLLHLAIADL-LVTFFCIPSEAIWAY-----TVAW-LAGntmcKLVK 77
                        90       100       110
                ....*....|....*....|....*....|...
gi 62473489 120 LCDSFG-YISIYIAVCFTIERFIAIRYPLKRQT 151
Cdd:cd15384  78 YLQVFGlYLSTYITVLISLDRCVAILYPMKRNQ 110
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
50-178 1.48e-06

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 50.20  E-value: 1.48e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIY-VLTRKRMRCTTNIYLTALAITDIAYLTCQLILSLQHYDYPKYHFKLYWQLYGYFVWLCDSFgyIS 128
Cdd:cd15202  10 IIVFSLFGNVLVCWiIFKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSVH--VS 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 62473489 129 IYIAVCFTIERFIAIRYPLKRQTfcTESLAKKVIAAVAIFCLLSTLSTAF 178
Cdd:cd15202  88 AYTLTAIAVDRYQAIMHPLKPRI--SKTKAKFIIAVIWTLALAFALPHAI 135
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
50-203 1.57e-06

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 49.87  E-value: 1.57e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNS-VSIYVLTRKRMRCTTNIYLTALAITDIAYLTCQLilslqhydyPkyhFKLYWQLYGYFV---WLCD--- 122
Cdd:cd14967   9 IILVTVFGNLlVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVM---------P---FSAVYTLLGYWPfgpVLCRfwi 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 123 ----SFGYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAV----AIFCLLSTLSTAFEHTITIGTRQIDDAYQ 194
Cdd:cd14967  77 aldvLCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVwvysLLISLPPLVGWRDETQPSVVDCECEFTPN 156

                ....*....
gi 62473489 195 PCNQTVANI 203
Cdd:cd14967 157 KIYVLVSSV 165
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
45-150 1.62e-06

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 49.74  E-value: 1.62e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPC---VFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIAYLTCQLILSLqhydypKYHFKLYWQLYG----Y 116
Cdd:cd15394   2 LIIPLyslVVLVGVVGNYLLIYVICRtKKMHNVTNFLIGNLAFSDMLMCATCVPLTL------AYAFEPRGWVFGrfmcY 75
                        90       100       110
                ....*....|....*....|....*....|....*
gi 62473489 117 FVWLCDSFG-YISIYIAVCFTIERFIAIRYPLKRQ 150
Cdd:cd15394  76 FVFLMQPVTvYVSVFTLTAIAVDRYYVTVYPLRRR 110
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
50-174 1.64e-06

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 49.80  E-value: 1.64e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIAY------LTCQLILSlqhydypkyhfklYWQlYGYFV---- 118
Cdd:cd15974  10 VCAIGLSGNTLVIYVVLRyAKMKTVTNIYILNLAVADELFmlglpfLATQNAIS-------------YWP-FGSFLcrlv 75
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62473489 119 -WLCDSFGYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTL 174
Cdd:cd15974  76 mTVDGVNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVL 132
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
42-152 1.75e-06

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 49.57  E-value: 1.75e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  42 VQRILVPCVFVIGLLGNSVSIYVLTRKRMRCT-TNIYLTALAITDiayltCQLILSLqhydyPkyhFKLYWQL------- 113
Cdd:cd15164   2 IQLIIYIPILFFGLLFNVLALWVFCCKMKKWTeTRVYMINLAVAD-----CCLLFSL-----P---FVLYFLKhswpdde 68
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 62473489 114 ------YGYFVwlcdsFGYISIYIAVCFTIERFIAIRYPLKRQTF 152
Cdd:cd15164  69 lclvlqSIYFI-----NRYMSIYIITAIAVDRYIAIKYPLKAKSL 108
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
46-143 2.01e-06

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 49.44  E-value: 2.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  46 LVPCVFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIAYLtcqlilslqhYDYPKYHFKLYWQLYGYFVWLC--- 121
Cdd:cd15185   6 LYSLVFIVGLLGNVVVVVILIKyRRLRIMTNIYLLNLAISDLLFL----------FTLPFWIHYVRWNNWVFGHGMCkll 75
                        90       100
                ....*....|....*....|....*.
gi 62473489 122 DSFGYISIYIAVCF----TIERFIAI 143
Cdd:cd15185  76 SGFYYLGLYSEIFFiillTIDRYLAI 101
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
45-174 2.44e-06

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 49.22  E-value: 2.44e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCVFVI----GLLGNSVSIY-VLTRKRMRCTTNIYLTALAITD--IAYLTCQLILS-LQHYDYPkyhFKLYWQLYGY 116
Cdd:cd15390   1 VLWSIVFVVmvlvAIGGNLIVIWiVLAHKRMRTVTNYFLVNLAVADllISAFNTVFNFTyLLYNDWP---FGLFYCKFSN 77
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 62473489 117 FVWLCDSFgyISIYIAVCFTIERFIAIRYPLKRQTfctesLAKKVIAAVAIFCLLSTL 174
Cdd:cd15390  78 FVAITTVA--ASVFTLMAISIDRYIAIVHPLRPRL-----SRRTTKIAIAVIWLASFL 128
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
358-486 3.94e-06

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 48.75  E-value: 3.94e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 358 LFTLLVFV---VFPLLLLATFN-SILILLVHRSKNLRGDLTNASSIRRTKRKSNsglkgsvsqeNRVTITLIAVVLMFIV 433
Cdd:cd15203 166 IYTISVLVlqfVIPLLIISFCYfRISLKLRKRVKKKRGKRTLSSRRRRSELRRK----------RRTNRLLIAMVVVFAV 235
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 62473489 434 CQLPWAIY-LIVNQYMEIQIGTQ--VVAGNVCNLLASLHAASNFFLYCVLSDKYRK 486
Cdd:cd15203 236 CWLPLNLFnLLRDFEPLPQIDGRhfYLIFLICHLIAMSSACVNPLLYGWLNDNFRK 291
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
50-183 4.32e-06

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 48.58  E-value: 4.32e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITD--IAYLTCQLILSlqhydypkYHFKLYWQlYGYFVwlCDSFGY 126
Cdd:cd14992  10 IILVSVVGNFIVIAALARhKNLRGATNYFIASLAISDllMALFCTPFNFT--------YVVSLSWE-YGHFL--CKIVNY 78
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62473489 127 I-------SIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAFEHTIT 183
Cdd:cd14992  79 LrtvsvyaSSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTE 142
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
50-174 5.07e-06

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 48.36  E-value: 5.07e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLT-RKRMRCTTNIYLTALAITDIAYLtcqLILSLQHYDYpkyhfkLYWQLYGYFvwLCDSFG--- 125
Cdd:cd14984  10 VFLLGLVGNSLVLLVLLyYRKLRSMTDVYLLNLALADLLFV---LTLPFWAVYA------ADGWVFGSF--LCKLVSaly 78
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 62473489 126 ----YISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTL 174
Cdd:cd14984  79 tinfYSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSL 131
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
50-174 5.49e-06

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 48.30  E-value: 5.49e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIAYLTCQLILSLQHYdypkyhfKLYW---QLYGYFVWLCDSFG 125
Cdd:cd15971  10 VCIIGLCGNTLVIYVILRyAKMKTVTNIYILNLAIADELFMLGLPFLAIQVA-------LVHWpfgKAICRVVMTVDGIN 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 62473489 126 -YISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTL 174
Cdd:cd15971  83 qFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVIL 132
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
50-189 6.26e-06

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 48.22  E-value: 6.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTR--KRMRCTTnIYLTALAITDIAYLtCQLILSLQHYDYPK-----------YHFKLYWQLYGy 116
Cdd:cd16001  10 VFVLGLPLNGTVLWLSWCrtKRWTCST-IYLVNLAVADLLYV-CSLPLLIVNYAMRDrwpfgdflcklVRFLFYTNLYG- 86
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62473489 117 fvwlcdsfgyiSIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLST-AFEHTITIGTRQI 189
Cdd:cd16001  87 -----------SILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIGSAATWILVVLQLLPTlVYARTGSINNRTV 149
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
45-178 7.31e-06

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 47.81  E-value: 7.31e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCV----FVIGLLGNS-VSIYVLTRKRMRCTTNIYLTALAITDIAYLtcqLILSL-QHYDYPKYHfklyWQLYGYFV 118
Cdd:cd15192   1 IMIPTVysiiFVVGIFGNSlVVIVIYCYMKLKTVANIFLLNLALADLCFL---ITLPLwAAYTAMEYH----WPFGNFLC 73
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62473489 119 WLCDSF----GYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAF 178
Cdd:cd15192  74 KIASALvsfnLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAII 137
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
50-167 7.65e-06

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 47.85  E-value: 7.65e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTRKR-MRCTTNIYLTALAITD-------IAYLTCQLILSlqhydypkyhfklYWQLyGYFVwlC 121
Cdd:cd15205  10 IFVLALFGNSLVIYVVTRKRaMRTATNIFICSLALSDllitffcIPFTLLQNISS-------------NWLG-GAFM--C 73
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 62473489 122 DSFGYI-------SIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAI 167
Cdd:cd15205  74 KMVPFVqstavvtSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWI 126
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
50-172 7.74e-06

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 47.76  E-value: 7.74e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLT-RKRMRCTTNIYLTALAITDIAYLtcqLILSLqhydYPKYHFKLYWQLYGYFvwLCDSFG--- 125
Cdd:cd14985  10 IFLVGLLGNLFVVWVFLfPRGPKRVADIFIANLAAADLVFV---LTLPL----WATYTANQYDWPFGAF--LCKVSSyvi 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 62473489 126 ----YISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAV-AIFCLLS 172
Cdd:cd14985  81 svnmFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIwVVACLLS 132
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
51-172 9.36e-06

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 47.40  E-value: 9.36e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  51 FVIGLLGNSVSI--YVLTRKRMRCTtNIYLTALAITDIAYLtCQLILSLQHYDYPKYhfklywqLYGYFVWLCDSF---- 124
Cdd:cd15378  11 FVLGFIGNTIVIlgYIFCLKNWKSS-NIYLFNLSVSDLAFL-CTLPMLVYSYSNGQW-------LFGDFLCKSNRYllha 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 62473489 125 -GYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAkkVIAAVAIFCLLS 172
Cdd:cd15378  82 nLYSSILFLTFISIDRYLLIKYPFREHILQKKRSA--VAISLAIWVLVT 128
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
50-174 1.55e-05

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 46.87  E-value: 1.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIAYLTcqlILSLQHYDYPKYHFKLYWQLYGYFVWLCDSFGYIS 128
Cdd:cd15091  10 VFVVGLVGNSLVMFVIIRyTKMKTATNIYIFNLALADALVTT---TMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTS 86
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 62473489 129 IYIAVCFTIERFIAIRYPLKRQTFCTESLAKkvIAAVAIFCLLSTL 174
Cdd:cd15091  87 IFTLTMMSVDRYIAVCHPVKALDFRTPLKAK--IINICIWLLSSSV 130
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
42-178 1.67e-05

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 46.99  E-value: 1.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  42 VQRILVPCV-FVIGLLGNSVSIYVLTRKRM-RCTTNIYLTALAITDIayLTCQLILSLQhydypkyhfkLYWQLYGYFV- 118
Cdd:cd14986   1 VSRVAVLGVlFVFTLVGNGLVILVLRRKRKkRSRVNIFILNLAIADL--VVAFFTVLTQ----------IIWEATGEWVa 68
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62473489 119 --WLCDSFGYI-------SIYIAVCFTIERFIAIRYPLKRQTfcTESLAKKVIAAVAIFCLLSTLSTAF 178
Cdd:cd14986  69 gdVLCRIVKYLqvvglfaSTYILVSMSLDRYQAIVKPMSSLK--PRKRARLMIVVAWVLSFLFSIPQLV 135
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
49-174 1.78e-05

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 46.58  E-value: 1.78e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  49 CVFVIGllGNS-VSIYVLTRKRMRCTTNIYLTALAITD--IAYLTCQLILSLQHYDYPKYHFKL--YWqlYGYFVWLCDS 123
Cdd:cd15061  10 IIFTIF--GNLlVILAVATTRRLRTITNCYIVSLATADllVGVLVLPLAIIRQLLGYWPLGSHLcdFW--ISLDVLLCTA 85
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 62473489 124 fgyiSIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTL 174
Cdd:cd15061  86 ----SILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITS 132
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
45-167 2.20e-05

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 46.33  E-value: 2.20e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCVFVIGLLGNSVSIYVLT-RKRMRCTTNIYLTALAITDIAYltcqlILSLQhydYPKYHFKLYWQLYGYFVWLCDS 123
Cdd:cd15187   5 VLYCLLFVFGLLGNSLVIWVLVaCKKLRSMTDVYLLNLAASDLLF-----VFSLP---FQAYYLLDQWVFGNAMCKIVSG 76
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 62473489 124 FGYISIYIAVCF----TIERFIAI---RYPLKRQTFCTESLAKKVIAAVAI 167
Cdd:cd15187  77 AYYIGFYSSMFFitlmSIDRYLAIvhaVYALKVRTASHGTILSLALWLVAI 127
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
50-184 2.53e-05

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 46.31  E-value: 2.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489   50 VFVIGLLGNSVSIYVLTRKRMRCTTNIYLTALAITDIAYLtcqLILSLQHYDYPKYHfklyWQLYGYFVWLCDSFGYISI 129
Cdd:PHA03087  50 IFFFGLVGNIIVIYVLTKTKIKTPMDIYLLNLAVSDLLFV---MTLPFQIYYYILFQ----WSFGEFACKIVSGLYYIGF 122
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62473489  130 YIAVCF----TIERFIAIRYPLKRQTFCTE------SLAKKVIAAVAIFCLLSTLSTAFEHTITI 184
Cdd:PHA03087 123 YNSMNFitvmSVDRYIAIVHPVKSNKINTVkygyivSLVIWIISIIETTPILFVYTTKKDHETLI 187
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
349-486 2.60e-05

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 46.29  E-value: 2.60e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 349 DELYSYLWNLFTLLVFVVFPLLLLAtfnsiLILLVHRSKNLRGDLTNASSIRRTKRksnsglkgsvsqenrVTITLIAVV 428
Cdd:cd15088 159 DDLYWFTIYHFILGFAVPLVVITVC-----YILILHRLARGVAPGNQSHGSSRTKR---------------VTKMVILIV 218
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 62473489 429 LMFIVCQLPWAIYLIVNQYMEIQIGTQVVAGNVCNLLASLHAASNFFLYCVLSDKYRK 486
Cdd:cd15088 219 VVFIVCWLPFHVVQLVNLAMNRPTLAFEVAYFLSICLGYANSCLNPFVYILVSENFRK 276
7tmA_GPR142 cd15129
G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G ...
393-488 2.71e-05

G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR142, a vertebrate orphan receptor, is very closely related to GPR139, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating enhancement of glucose-stimulated insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320257 [Multi-domain]  Cd Length: 270  Bit Score: 45.92  E-value: 2.71e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 393 LTNASSIRRTKRKSNSglKGSVSQENRVTITLIAVVLMFIVCQLPWAIYLIVNQYM-EIQIGTQV-VAGNVCNLLASLHA 470
Cdd:cd15129 175 VTNSVIIHKLRRRKGR--SGPQRRSGKTTAILLAITTVFAVLWAPRTVVIIYHLYVsSVNRDWRVhLALDLANMLAMLNT 252
                        90
                ....*....|....*...
gi 62473489 471 ASNFFLYCVLSDKYRKTV 488
Cdd:cd15129 253 AVNFFLYCFVSKRFRRTV 270
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
45-165 2.89e-05

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 45.90  E-value: 2.89e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCVFVIGLLGNSVSIYVLT-RKRMRCTTNIYLTALAITDIAYLTCQLILSLQHYDYPKYHF-KLYWQLYgYFVwlcD 122
Cdd:cd15012   4 ILYTLVFCCCFFGNLLVILVVTsHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFgEVLCRMY-QFV---H 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 62473489 123 SFGY-ISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAV 165
Cdd:cd15012  80 SLSYtASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTV 123
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
50-178 3.87e-05

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 45.73  E-value: 3.87e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYV-LTRKRMRCTTNIYLTALAITDIAYltcQLILSlqhydypkyhfklYWQLYGYFVWLcdsFG--- 125
Cdd:cd15178  10 VFLLSLPGNSLVVLViLYNRRSRSSTDVYLLHLAIADLLF---ALTLP-------------FWAVSVVKGWI---FGtfm 70
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62473489 126 ------------YISIYIAVCFTIERFIAIRYPlkrqtfcTESLAKK------VIAAVAIFCLLSTLSTAF 178
Cdd:cd15178  71 cklvsllqeanfYSGILLLACISVDRYLAIVHA-------TRALTQKrhlvkfVCAGVWLLSLLLSLPALL 134
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
50-148 3.94e-05

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 45.45  E-value: 3.94e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYV-LTRKRMRCTTNIYLTALAITDIAYLTCqlILSLQHYdypkYHFKLYWQLyGYFVWLCDSFG--- 125
Cdd:cd15375  10 IFIVGFPGNIIAIFVyLFKMRPWKSSTIIMLNLALTDLLYVTS--LPFLIYY----YINGESWIF-GEFMCKFIRFIfhf 82
                        90       100
                ....*....|....*....|....*
gi 62473489 126 --YISIYIAVCFTIERFIAIRYPLK 148
Cdd:cd15375  83 nlYGSILFLTCFSIFRYVVIVHPLR 107
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
50-173 4.44e-05

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 45.47  E-value: 4.44e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTRKRMRCTT-NIYLTALAITDIAYLtCQLILSLqhyDYpkYHFKLYWQL---------YGYFVW 119
Cdd:cd15157  10 IFVLGVVGNGLSIYVFLQPSKKKTSvNIFMLNLAVSDLMFV-STLPFRA---DY--YLMGSHWVFgdiacrimsYSLYVN 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 62473489 120 LcdsfgYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLST 173
Cdd:cd15157  84 M-----YCSIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWIFVMAAS 132
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
41-174 4.89e-05

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 45.20  E-value: 4.89e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  41 VVQRILVPCVFVIGLLGNSVSIYVLTRKRMRC--TTNIYLTALAITDIAYLTCQLILSLQHYDYPKYHF-KLYWQLYGYF 117
Cdd:cd15097   1 VIVPVVFSLIFLLGTVGNSLVLAVLLRSGQSGhnTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFgSFLCKAVHFF 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62473489 118 VWLCdsfGYISIYIAVCFTIERFIAIRYPLKRQTFCTeslAKKVIAAVAIFCLLSTL 174
Cdd:cd15097  81 IYLT---MYASSFTLAAVSVDRYLAIRYPLRSRELRT---PRNAVAAIALIWGLSLL 131
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
45-152 6.08e-05

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 45.10  E-value: 6.08e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCVF----VIGLLGNSVSIYVLTRKR--MRC-TTNIYLTALAITDIAYLTCQLILSLQHYDYPKyhfklyWQLYGYF 117
Cdd:cd15098   1 VIVPVVFglifCLGVLGNSLVITVLARVKpgKRRsTTNVFILNLSIADLFFLLFCVPFQATIYSLPE------WVFGAFM 74
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 62473489 118 VWLCDSFGYI----SIYIAVCFTIERFIAIRYPLKRQTF 152
Cdd:cd15098  75 CKFVHYFFTVsmlvSIFTLVAMSVDRYIAVVHSRTSSSL 113
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
45-174 6.78e-05

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 44.75  E-value: 6.78e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCVF----VIGLLGNSVSIYVLTRKR-MRCTTNIYLTALAITDIAYLTCQLILSLQHYDYPKYHF-----KLYWQLY 114
Cdd:cd15088   1 VIMPSVFgcicVVGLVGNGIVLYVLVRCSkLRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIDGQWYFgevmcKIITALD 80
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 115 GyfvwlCDSFGyiSIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTL 174
Cdd:cd15088  81 A-----NNQFT--STYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSIL 133
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
41-180 7.07e-05

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 44.78  E-value: 7.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  41 VVQRILVPCVFVIGLLGNSVSIY-VLTRKRMRCTTNIYLTALAITDIAYLtcqLILSLQHYDYPKYHFKLYWQLYGYFVW 119
Cdd:cd14975   1 VLGCTLLSLAFAIGLPGNSFVIWsILIKVKQRSVTMLLVLNLALADLAVL---LTLPVWIYFLATGTWDFGLAACKGCVY 77
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62473489 120 LCDSFGYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAV-AIFCLLSTLSTAFEH 180
Cdd:cd14975  78 VCAVSMYASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIwLLAVLLATPVIAFRH 139
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
50-171 7.09e-05

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 44.92  E-value: 7.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYV-LTRKRMRCTTNIYLTALAITDIAYLTCQLILSLQHYDYPKYHF-KLYWQLYGYFVWlcdSFGYI 127
Cdd:cd16003  10 VVAVAVFGNLIVIWIiLAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFgEAYCRFHNFFPI---TSVFA 86
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 62473489 128 SIYIAVCFTIERFIAIRYPLKRQTFCTESlaKKVIAAVAIFCLL 171
Cdd:cd16003  87 SIYSMTAIAVDRYMAIIDPLKPRLSATAT--KVVIGSIWILAFL 128
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
50-178 7.70e-05

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 44.55  E-value: 7.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTRKR----MRCTTNIYLTALAITDIAYLTCQLILSLqhYDYPKYHFKlyWQL-----YGYFvWL 120
Cdd:cd15130  10 LFVVGTVGNSVTLFTLARKKslqsLQSTVRYHLGSLALSDLLILLLAMPVEL--YNFIWVHHP--WAFgdagcRGYY-FL 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 62473489 121 CDSFGYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAF 178
Cdd:cd15130  85 RDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLF 142
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
52-171 8.09e-05

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 44.41  E-value: 8.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  52 VIGLLGNS-VSIYVLTRKRMRCTTNIYLTALAITDIAYLTCQLILSLQHYDYPKYHFKLYW-QLY-GYFVWLCDSfgyiS 128
Cdd:cd15063  12 VLVVLGNLlVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWcQIWlAVDVWMCTA----S 87
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 62473489 129 IYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLL 171
Cdd:cd15063  88 ILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFV 130
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
41-165 9.14e-05

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 44.39  E-value: 9.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  41 VVQRILVPCVFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIAYLTCQLIL----SLQHYDYPKYHFKLywqlyg 115
Cdd:cd15094   1 LISAVLYGLICIVGLVGNGLVIYVVLRyAKMKTVTNLYILNLAVADECFLIGLPFLivtmILKYWPFGAAMCKI------ 74
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 62473489 116 YFVWLCDSFgYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAV 165
Cdd:cd15094  75 YMVLTSINQ-FTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATT 123
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
50-174 9.23e-05

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 44.36  E-value: 9.23e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIAYLTCQLILSLQhydypkYHFKLYWQLYGYFVWLCDSF---- 124
Cdd:cd15191  10 IFILGFLGNSLVVCVFCHqSGPKTVASIYIFNLAVADLLFLATLPLWATY------YSYGYNWLFGSVMCKICGSLltln 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 62473489 125 GYISIYIAVCFTIERFIAIRYPLK--RQTFCTESLAKKVIAAVAIFCLLSTL 174
Cdd:cd15191  84 LFASIFFITCMSVDRYLAVVYPLRsqRRRSWQARLVCLLVWVLACLSSLPTF 135
7TM_GPCR_Srx pfam10328
Serpentine type 7TM GPCR chemoreceptor Srx; Chemoreception is mediated in Caenorhabditis ...
52-171 9.88e-05

Serpentine type 7TM GPCR chemoreceptor Srx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srx is part of the Srg superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 431215  Cd Length: 262  Bit Score: 44.13  E-value: 9.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489    52 VIGLLGNSVSIYV-LTRKRMRCTTNIYLTALAITDIAYLTCQLILS-----LQHYDYPKYHFKLYWQLYGYFVWLcdsfg 125
Cdd:pfam10328   5 LIGLVANLLVFIAfLKLPSLKNSFGILCLSQAIGNAIICLIFLFYVvpmtlFQNSFLPEWLNSHIIGLIAMGLYE----- 79
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 62473489   126 yISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLL 171
Cdd:pfam10328  80 -ISPLSHLLIALNRFCAVFFPLKYEKIFSIKNTKIIIIFIWIVSII 124
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
45-178 1.13e-04

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 44.02  E-value: 1.13e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCVF----VIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIAYLTCQLILSLQHydypKYHFKLYWQLYGYFVW 119
Cdd:cd15972   1 VLIPLVYlvvcVVGLGGNTLVIYVVLRySASESVTNIYILNLALADELFMLGLPFLAAQN----ALSYWPFGSFMCRLVM 76
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 120 LCDSFG-YISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAF 178
Cdd:cd15972  77 TVDAINqFTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVI 136
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
46-161 1.24e-04

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 44.21  E-value: 1.24e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  46 LVPCVFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITD-----------IAYLT---------CQLILSLQHYDYpk 104
Cdd:cd15090   6 LYSIVCVVGLFGNFLVMYVIVRyTKMKTATNIYIFNLALADalatstlpfqsVNYLMgtwpfgnilCKIVISIDYYNM-- 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62473489 105 yhfklywqlygyfvwlcdsfgYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKV 161
Cdd:cd15090  84 ---------------------FTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIV 119
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
353-481 1.39e-04

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 43.96  E-value: 1.39e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 353 SYLWNLFTLLVFVVfPLLLLATFNSILILLvhrsknlrgdltnassIRRTKRKSNSGLKGSVSQENRVTITLIAVVLMFI 432
Cdd:cd14964 157 IYLTWGFLLVSFLL-PLVAFLVIFSRIVLR----------------LRRRVRAIRSAASLNTDKNLKATKSLLILVITFL 219
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 62473489 433 VCQLPWAIYLIVNQYMEIQIGTQVVAgNVCNLLASLHAASNFFLYCVLS 481
Cdd:cd14964 220 LCWLPFSIVFILHALVAAGQGLNLLS-ILANLLAVLASTLNPFIYCLGN 267
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
50-168 1.39e-04

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 43.97  E-value: 1.39e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIAYLtcqLILSL-QHYDYPKYHF-----KLYWQLY--GYFVwl 120
Cdd:cd15184  10 VFIFGFVGNMLVVLILINcKKLKSMTDIYLLNLAISDLLFL---LTLPFwAHYAANEWVFgnamcKLLTGLYhiGFFS-- 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 62473489 121 cdsfgyiSIYIAVCFTIERFIAI---RYPLKRQTFCTESLAKKVIAAVAIF 168
Cdd:cd15184  85 -------GIFFIILLTIDRYLAIvhaVFALKARTVTFGVVTSVVTWVVAVF 128
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
53-147 1.64e-04

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 43.54  E-value: 1.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  53 IGLLGNSVSIYVLTRKRMRCTTNIYLTALAITDIAYLTCQLILSLQHY-DYPKYHFKLYWQLyGYFVWLcDSFGY-ISIY 130
Cdd:cd15110  13 LGLVGNGIVLWFLGFRIRRNPFTVYILHLAIADFTFLLCIFILSIMYIgPFNFSHSRDYVAM-LIFIIL-FLFGYnTGLY 90
                        90
                ....*....|....*..
gi 62473489 131 IAVCFTIERFIAIRYPL 147
Cdd:cd15110  91 LLTAISVERCLSVLYPI 107
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
45-172 1.71e-04

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 43.65  E-value: 1.71e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCVF----VIGLLGNSVSIY-VLTRKRMRCTTN---IYLTALAITDIAYLTCQLILSLQHYDYPKYHFKLywQLYGY 116
Cdd:cd15338   1 VIMPSVFgvicFLGIIGNSIVIYtIVKKSKFRCQQTvpdIFIFNLSIVDLLFLLGMPFLIHQLLGNGVWHFGE--TMCTL 78
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 62473489 117 FVWLCDSFGYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLS 172
Cdd:cd15338  79 ITALDTNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLS 134
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
52-180 1.89e-04

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 43.55  E-value: 1.89e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  52 VIGLLGNSVSIYV-LTRKRMRCTTNIYLTALAITDIayltcqlILSLqhYDYPkYHFK---LYWQLYGYFvwLCDSFGYI 127
Cdd:cd15393  12 LVAVVGNFLVIWVvAKNRRMRTVTNIFIANLAVADI-------IIGL--FSIP-FQFQaalLQRWVLPRF--MCPFCPFV 79
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 128 -------SIYIAVCFTIERFIAIRYPLKRQtfCTESLAKKVIAAVAIFCLLSTLSTAFEH 180
Cdd:cd15393  80 qvlsvnvSVFTLTVIAVDRYRAVIHPLKAR--CSKKSAKIIILIIWILALLVALPVALAL 137
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
46-143 2.45e-04

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 42.94  E-value: 2.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  46 LVPCVFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIAYLTCQLIlslqhydYPKYHFKLYWQLYGYFVWLCDSF 124
Cdd:cd15183   6 LYSLVFIIGVVGNVLVVLVLIQhKRLRNMTSIYLFNLAISDLVFLFTLPF-------WIDYKLKDDWIFGDAMCKFLSGF 78
                        90       100
                ....*....|....*....|...
gi 62473489 125 GYISIYIAVCF----TIERFIAI 143
Cdd:cd15183  79 YYLGLYSEIFFiillTIDRYLAI 101
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
46-161 2.57e-04

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 43.02  E-value: 2.57e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  46 LVPCVFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDiAYLTCQLILSLQHYDYPKYHFKlywQLYGYFVWLCDSF 124
Cdd:cd15089   6 LYSVVCVVGLLGNVLVMYGIVRyTKMKTATNIYIFNLALAD-ALATSTLPFQSAKYLMETWPFG---ELLCKAVLSIDYY 81
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 62473489 125 G-YISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKV 161
Cdd:cd15089  82 NmFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLI 119
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
41-170 2.63e-04

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 43.00  E-value: 2.63e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  41 VVQRILVPCVFVIGLLGNSVSIYVLTRKRMR----------------CTTNIYLTALAITDIAYltcqlilslqHYDYPK 104
Cdd:cd14980   1 ISLRIFIWIIGILALIGNILVIIWHISSKKKkkkvpklliinlaiadFLMGIYLLIIAIADQYY----------RGRYAQ 70
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62473489 105 YHfkLYWQ-----LYGYFVWLCDSFGyiSIYIAVCFTIERFIAIRYPLKRQtFCTESLAKKVIAAVAIFCL 170
Cdd:cd14980  71 YS--EEWLrsppcLLACFLVSLSSLM--SVLMMLLITLDRYICIVYPFSNK-RLSYKSAKIILILGWLFSI 136
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
50-178 2.79e-04

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 42.84  E-value: 2.79e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTRKRMRCT-TNIYLTALAITDIAYlTCQLILSLQHYDYPKY-----------HFKLYWQLYGyf 117
Cdd:cd15968  10 VFLLGLPLNSVVLTRCCRHTKAWTrTAIYMVNLALADLLY-ALSLPLLIYNYAMRDRwlfgdfmcrlvRFLFYFNLYG-- 86
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62473489 118 vwlcdsfgyiSIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAF 178
Cdd:cd15968  87 ----------SILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILI 137
7tmA_GPR139 cd15919
G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G ...
53-174 2.97e-04

G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR139, a vertebrate orphan receptor, is very closely related to GPR142, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320585 [Multi-domain]  Cd Length: 270  Bit Score: 42.96  E-value: 2.97e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  53 IGLLGNSVSIYVLTR---KRMRCTTNiYLTALAITDIAYLtcqliLSLQHYDYPKYHFKLYWQLYGYFVWLCD----SFG 125
Cdd:cd15919  13 LGLPANILTVIILSQlvaRRQKSSYN-YLLALAAADILVL-----FFIVFVDFLLEDFILNKQMPQVLDKIIEvlefSSI 86
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 62473489 126 YISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTL 174
Cdd:cd15919  87 HTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSI 135
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
50-174 3.25e-04

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 42.93  E-value: 3.25e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIaylTCQLILSLQHYDYpkyhFKLYWQLYGYFVWLCDSFGYIS 128
Cdd:cd15092  10 VCVVGLVGNCLVMYVILRhTKMKTATNIYIFNLALADT---LVLLTLPFQGTDI----FLGFWPFGNALCKTVIAIDYYN 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 62473489 129 IYIAV----CFTIERFIAIRYPLKRQTFCTESLAKKViaAVAIFCLLSTL 174
Cdd:cd15092  83 MFTSTftltAMSVDRYVAICHPIKALDVRTPHKAKVV--NVCIWALASVV 130
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
50-180 3.33e-04

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 42.83  E-value: 3.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTRK-RMRCTTNIYLTALAITDiayLTCQLILSLQHYdypkYHFKLYWQLYGYFVWLCDSFGYIS 128
Cdd:cd15154  10 LFPVGLLLNAVALWVFVRYlRLHSVVSIYMCNLALSD---LLFTLSLPLRIY----YYANHYWPFGNFLCQFSGSIFQMN 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 62473489 129 IY----IAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAFEH 180
Cdd:cd15154  83 MYgsclFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGGSVPAAIVH 138
7tmA_GPR139 cd15919
G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G ...
395-485 3.34e-04

G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR139, a vertebrate orphan receptor, is very closely related to GPR142, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320585 [Multi-domain]  Cd Length: 270  Bit Score: 42.58  E-value: 3.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 395 NASSIRRTKRKSNSGLKGSVSqeNRVTITLIAVVLMFIVCQLPWAIYLIVNQYME-IQIGTQV-VAGNVCNLLASLHAAS 472
Cdd:cd15919 177 NSIIVYKLRRKSNFRLRGYST--GKTTAILFTITSIFAILWAPRIIMILYHLYVSpINNSWLVhIVSDIANMLALLNTAI 254
                        90
                ....*....|...
gi 62473489 473 NFFLYCVLSDKYR 485
Cdd:cd15919 255 NFFLYCFISKRFR 267
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
353-486 3.75e-04

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 42.43  E-value: 3.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 353 SYLWNLFTLLVFVVFPLLLLATFNSILILLVHRSKNLRGdltnassiRRtkrksnsglkgsvsqenRVTITLIAVVLMFI 432
Cdd:cd15012 164 SKLYDTINFIVWYLIPLLIMTVLYSKISIVLWKSSSIEA--------RR-----------------KVVRLLVAVVVSFA 218
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62473489 433 VCQLPWAIYLIVNQYMEIQIGT---QVVAGNVCNLLASLHAASNFFLYCVLSDKYRK 486
Cdd:cd15012 219 LCNLPYHARKMWQYWSEPYRCDsnwNALLTPLTFLVLYFNSAVNPLLYAFLSKRFRQ 275
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
50-171 3.97e-04

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 42.54  E-value: 3.97e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYV-LTRKRMRCTTNIYLTALAITDIAYLTCQLILSLQHYDYPKYHFKLYWQLYGYFVWLCDSFGyiS 128
Cdd:cd16002  10 IVVVSVVGNIIVMWIiLAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFPIAAVFA--S 87
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 62473489 129 IYIAVCFTIERFIAIRYPLKRQTFCTESlaKKVIAAVAIFCLL 171
Cdd:cd16002  88 IYSMTAIALDRYMAIIHPLQPRLSATAT--KVVICVIWVLAFL 128
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
50-179 4.57e-04

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 42.25  E-value: 4.57e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIAYltCQLILSLQhydypkyhFKLYWQLYgyfvW-----LCDS 123
Cdd:cd15210  10 FMVVGVPGNLLTVLALLRsKKLRTRTNAFIINLSISDLLF--CAFNLPLA--------ASTFLHQA----WihgetLCRV 75
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62473489 124 FGY-------ISIYIAVCFTIERFIAIRYP-LKRQTFCTESLAkKVIAAVAIFCLLSTLSTAFE 179
Cdd:cd15210  76 FPLlryglvaVSLLTLVLITLNRYILIAHPsLYPRIYTRRGLA-LMIAGTWIFSFGSFLPLWLG 138
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
57-188 4.95e-04

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 42.26  E-value: 4.95e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  57 GNSVSIYVLTR-KRMRCTTNIYLTALAITD--IAYLTCQLILslqhyDYpkYHFK-LYWQlYGYFvwLCDSFGYI---SI 129
Cdd:cd15204  17 GNLLLIAVLARyKKLRTLTNLLIANLALSDflVAVFCLPFEM-----DY--YVVRqRSWT-HGDV--LCAVVNYLrtvSL 86
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62473489 130 YIA----VCFTIERFIAIRYPL----KRQTFCTeslakkVIAAVAIFCLLSTLSTAFEHTITIGTRQ 188
Cdd:cd15204  87 YVStnalLVIAIDRYLVIVHPLkprmKRRTACV------VIALVWVVSLLLAIPSAVYSKTTPYANQ 147
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
50-181 5.30e-04

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 42.09  E-value: 5.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTRKRMRCTT-NIYLTALAITDIAYLTCqlilslqhydypkYHFKLYWQLYGYFVWLCDSFG--- 125
Cdd:cd15920  10 ICIVGLLSNTLALWVFFLRQQRETSiSVYMRNLALADLLLVLC-------------LPFRVAYQNTAGPLSFCKIVGaff 76
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62473489 126 YISIYIAVCF----TIERFIAIRYPLKR---QTFCTESLAKKVIAAVAIFCLLSTLSTAFEHT 181
Cdd:cd15920  77 YLNMYASILFlsliSLDRYLKIIKPLQQfkiHTVPWSSAASGGVWLLLLACMIPFLFESRNEG 139
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
42-171 6.89e-04

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 41.80  E-value: 6.89e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  42 VQRILVPCVFVIGLLGNSVSI-YVLTRKRMRCTTNIYLTALAITDI---AYLTCqlILSL-QHY--DYPKYhfKLYWQly 114
Cdd:cd15137   2 VLRVFIWVVGIIALLGNLFVLiWRLKYKEENKVHSFLIKNLAIADFlmgVYLLI--IASVdLYYrgVYIKH--DEEWR-- 75
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62473489 115 gyFVWLCDSFGYI-------SIYIAVCFTIERFIAIRYPLKRQTFcTESLAKKVIAAVAIFCLL 171
Cdd:cd15137  76 --SSWLCTFAGFLatlssevSVLILTLITLDRFICIVFPFSGRRL-GLRRAIIVLACIWLIGLL 136
7TM_GPCR_Srsx pfam10320
Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis ...
51-197 7.05e-04

Serpentine type 7TM GPCR chemoreceptor Srsx; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srsx is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 255903 [Multi-domain]  Cd Length: 257  Bit Score: 41.43  E-value: 7.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489    51 FVIGLLGNSVSIYV-LTRKRMRCTTNIYLTALAITDIAYLTCQLILSlqhydypkYHFKLYWQLYGYFvwlCdsFGYISI 129
Cdd:pfam10320   1 SVIGLFGNVLMIHLtFRKKKLRSKCSILICVQCIAHLICLCGEIVFV--------VLLFTGTQLTRNE---C--FWMISF 67
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62473489   130 YI-AVCF--------TIERFIAIRYPLKRQTFCTEslakKVIAAVAIFCLLSTLSTAFehtitIGTRQIDDAYQP-CN 197
Cdd:pfam10320  68 YIfGQTAqgplmlmiGIDRLIAVKFPIFYRLLSSS----KYLFIQLIFPVIYSSFITV-----YGFLQRDDETIIvCA 136
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
353-486 7.87e-04

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 41.52  E-value: 7.87e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 353 SYLW-NLFTLLVFV---VFPLLLLATFNSILILLVHRSKNLRGDLTNASSIRRtkrksnsglkgsvsqenrVTITLIAVV 428
Cdd:cd15090 157 SWYWeNLLKICVFIfafIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRR------------------ITRMVLVVV 218
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 62473489 429 LMFIVCQLPWAIYLIVNQYMEIQIGT-QVVAGNVCNLLASLHAASNFFLYCVLSDKYRK 486
Cdd:cd15090 219 AVFIVCWTPIHIYVIIKALVTIPETTfQTVSWHFCIALGYTNSCLNPVLYAFLDENFKR 277
7tmA_TXA2_R cd15143
thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
52-171 9.38e-04

thromboxane A2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The thromboxane receptor, also known as the prostanoid TP receptor, is a class A G-protein coupled receptor whose endogenous ligand is thromboxane A2 (TXA2). TXA2 is the major product of cyclooxygenase metabolite of arachidonic acid that found predominantly in platelets and stimulates platelet aggregation, Ca2+ influx into platelets, and also causes vasoconstriction. TXA2 has been shown to be involved in immune regulation, angiogenesis and metastasis, among many others. Activation of TXA2 receptor is coupled to G(q) and G(13), resulting in the activations of phospholipase C and RhoGEF, respectively. TXA2 receptor is widely distributed in the body and is abundantly expressed in thymus and spleen.


Pssm-ID: 320271 [Multi-domain]  Cd Length: 296  Bit Score: 41.34  E-value: 9.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  52 VIGLLGNSVSIYVL------TRKRMRCTTNIYLTALAITDIAYL--TCQLILSlqhydypkYHFKLY-WQLYGYFVWLCD 122
Cdd:cd15143  12 AIGLASNLFAFIVLvkssrkTKSRSRSSFLIFLCGLVVTDFLGLlvTGTIVIS--------FHLTNFnWRVVDPDCYLCN 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 62473489 123 SFGYISIYIAVC-------FTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLL 171
Cdd:cd15143  84 FMGLSMVFYGLCplllgatMAVERFFGINRPFSRSTAMSKRRAWYMVGMVWAFAFL 139
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
41-181 1.01e-03

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 41.29  E-value: 1.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  41 VVQRILVPCVFVIGLLGNSVSIYVLTRKRMRCTTNIYLTALAITDIAYlTCQLILSLQhYDYPKYHFklywqLYGYFVWL 120
Cdd:cd15116   1 ILSMVIYSVVFVLGVLGNGLVIFITGFKMKKTVNTVWFLNLAVADFLF-TFFLPFSIA-YTAMDFHW-----PFGRFMCK 73
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62473489 121 CDSF-----GYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCL-LSTLSTAFEHT 181
Cdd:cd15116  74 LNSFllflnMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFfLSSPSFIFRDT 140
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
50-171 1.04e-03

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 41.22  E-value: 1.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTRK-RMRCTTNIYLTALAITDIAYlTCQLIL----SLQHYDYPkyHFKLYWQLYGYFVWLcdSF 124
Cdd:cd15160  10 VFVVGLPANCLALWVLYLQiKKENVLGVYLLNLSLSDLLY-ILTLPLwidyTANHHNWT--FGPLSCKVVGFFFYT--NI 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 62473489 125 gYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLL 171
Cdd:cd15160  85 -YASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELG 130
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
50-174 1.05e-03

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 41.29  E-value: 1.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTR---KRMRcTTNIYLTALAITDIAYLtcqLILSL-QHYDYPKYHF---KLYWQLYGYFVWLCd 122
Cdd:cd15190  20 VFVLGLSGNGLVLWTVFRskrKRRR-SADTFIANLALADLTFV---VTLPLwAVYTALGYHWpfgSFLCKLSSYLVFVN- 94
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 62473489 123 sfGYISIYIAVCFTIERFIAIRYPLKRQTFCTESlakKVIAAVAIFCLLSTL 174
Cdd:cd15190  95 --MYASVFCLTGLSFDRYLAIVRSLASAKLRSRT---SGIVALGVIWLLAAL 141
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
328-444 1.09e-03

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 41.14  E-value: 1.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 328 NVTEYCQNVTY-----YNHglsELGYdelysylwNLFTLLVFVVFPLLL-LATFNSILILLVHRSKNLRGDLTNASSIRR 401
Cdd:cd15382 145 CVTWFSQCVTFnffpsHDH---ELAY--------NIFNMITMYALPLIIiVFCYSLILCEISRKSKEKKEDVSEKSSSVR 213
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 62473489 402 TKRKSNSGLKGSVSQENRVTITliaVVLMFIVCQLPWAIYLIV 444
Cdd:cd15382 214 LRRSSVGLLERARSRTLKMTIV---IVLVFIICWTPYFIMSLW 253
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
50-168 1.14e-03

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 41.17  E-value: 1.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIAYLTCQLILSLQhydypkyHFKLYWQLYGYFVWLCDSFG-YI 127
Cdd:cd15389  10 IIVISLFGNSLVCHVIFKnKRMHTATNLFIVNLAVSDILITLLNTPFTLV-------RFVNSTWVFGKIMCHLSRFAqYC 82
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 62473489 128 SIYIAVcFT-----IERFIAIRYPLK-RQTFCTESLAKKVIAAVAIF 168
Cdd:cd15389  83 SVYVST-LTltaiaLDRHRVILHPLKpRITPCQGVVVIAIIWIMASC 128
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
50-149 1.14e-03

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 41.14  E-value: 1.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTRKRMR--CTTNIYLTALAITDIaYLTCQLIlslqhydyPK---YHFKLYW-------QLYGYF 117
Cdd:cd15382  10 LFLIAAVGNLTVLLILLRNRRRkrSRVNILLMHLAIADL-LVTFIMM--------PLeigWAATVAWlagdflcRLMLFF 80
                        90       100       110
                ....*....|....*....|....*....|...
gi 62473489 118 vwlcDSFG-YISIYIAVCFTIERFIAIRYPLKR 149
Cdd:cd15382  81 ----RAFGlYLSSFVLVCISLDRYFAILKPLRL 109
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
45-165 1.35e-03

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 40.76  E-value: 1.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCVFVIGLLGNS-VSIYVLTRKRMRCTTNIYLTALAITD----IAYLTCQLILSLQHYDYP--KYHFKLYWQLYgyf 117
Cdd:cd15052   5 LLLLLLVIATIGGNIlVCLAISLEKRLQNVTNYFLMSLAIADllvgLLVMPLSILTELFGGVWPlpLVLCLLWVTLD--- 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 62473489 118 VWLCDSfgyiSIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAV 165
Cdd:cd15052  82 VLFCTA----SIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIV 125
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
50-148 1.43e-03

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 40.93  E-value: 1.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIAYLtcqLILSLQHYDYPKYHfklyWQLYGYFVWLCDSFGYIS 128
Cdd:cd15153  10 IFIPGLLANSAALWVLCRfISKKNKAIIFMINLAVADLAHV---LSLPLRIHYYIQHT----WPFGRFLCLLCFYLKYLN 82
                        90       100
                ....*....|....*....|....
gi 62473489 129 IYIAVCF----TIERFIAIRYPLK 148
Cdd:cd15153  83 MYASICFltciSIQRCFFLLHPFK 106
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
50-180 1.48e-03

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 40.83  E-value: 1.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIAYLTCQLILSLQHYDYPKYHFKlywqlygyfVWLCDSFG--- 125
Cdd:cd15148  10 IFLFGLVGNLLALWVFLFiHRKRNSVRIFLINVAIADLLLIICLPFRILYHVNNNQWTLG---------PLLCKVVGnlf 80
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62473489 126 ----YISIYIAVCFTIERFIAIRYPLKRQTFCTES---LAKKVIAAVAIFCLLSTLSTAFEH 180
Cdd:cd15148  81 ymnmYISIILLGFISLDRYLKINRSSRRQKFLTRKwsiVACGVLWAVALVGFVPMIVLTEKN 142
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
45-168 1.50e-03

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 40.59  E-value: 1.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCVFVIGLLGNSVSIYVLTR-KRMRCTTNIYLTALAITDIAYLTCQLILSLQHYDYPKYHF-KLYWQLYGYFVWLCD 122
Cdd:cd15008   4 LVFGVLWLVSVFGNSLVCLVIHRsRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLgSAMCKLVRYFQYLTP 83
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 62473489 123 SfgyISIYIAVCFTIERFIAIRYPLKRQTfcTESLAKKVIAAVAIF 168
Cdd:cd15008  84 G---VQIYVLLSICVDRFYTIVYPLSFKV--SREKAKKMIAASWLF 124
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
45-171 1.52e-03

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 40.61  E-value: 1.52e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCVFVIGLLGNSVSIYVLTRKR-MRCTTNIYLTALAITDIAYLtcqLILSLQhydypkYHFKLYWQLYGYFVWLCDS 123
Cdd:cd15194   5 ILYCLVFLVGAVGNAILMGALVFKRgVRRLIDIFISNLAASDFIFL---VTLPLW------VDKEVVLGPWRSGSFLCKG 75
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 62473489 124 FGYI-------SIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIF-CLL 171
Cdd:cd15194  76 SSYIisvnmycSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLsCLL 131
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
50-173 1.54e-03

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 40.68  E-value: 1.54e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTRKRMRCT-TNIYLTALAITDIAYLTC----QLILSLQHYDY-PKYHFKL--YWQLYGYfvwlc 121
Cdd:cd15196  10 ILVLALFGNSCVLLVLYRRRRKLSrMHLFILHLSVADLLVALFnvlpQLIWDITYRFYgGDLLCRLvkYLQVVGM----- 84
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 62473489 122 dsfgYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLST 173
Cdd:cd15196  85 ----YASSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMVAIAWVLSLLLSI 132
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
50-174 1.56e-03

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 40.51  E-value: 1.56e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVL-TRKRMRCTTNIYLTALAITDIAYLTCqlilslqhydypkYHFKLYWQLYG----YFVWLCD-- 122
Cdd:cd15162  10 VFVVGLPANGMALWVLlFRTKKKAPAVIYMANLAIADLLLVIW-------------LPFKIAYHIHGnnwiFGEALCRlv 76
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62473489 123 -----SFGYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTL 174
Cdd:cd15162  77 tvafyGNMYCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTL 133
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
49-147 1.86e-03

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 40.25  E-value: 1.86e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  49 CVFVIGLLGNSVSIYV-LTRKRMRCTTNIYLTALAITDIAYLTCQLILSLQHYDYPKYHFKLYWQLYGYFVWLCdsfGYI 127
Cdd:cd15079   9 FLGIVSLLGNGLVIYIfSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFIYNSFYEGWALGPLGCQIYAFLGSLS---GIG 85
                        90       100
                ....*....|....*....|
gi 62473489 128 SIYIAVCFTIERFIAIRYPL 147
Cdd:cd15079  86 SIWTNAAIAYDRYNVIVKPL 105
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
46-192 1.97e-03

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 40.32  E-value: 1.97e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  46 LVPCVFVIG-LLGNSVSIYVLT-RKRMRCTTNIYLTALAITDIayLTCQLILSLQHYDYPKYHFKLYWQLYgyFVWLCDS 123
Cdd:cd15307   5 LLALVLVLGtAAGNILVCLAIAwERRLQNVTNYFLMSLAITDL--MVAVLVMPLGILTLVKGHFPLSSEHC--LTWICLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 124 --FGYISIYIAVCFTIERFIAIRYPLKrqtFCTESLAKKVIAAVAIFCLLS-------TLSTAFEHTITI--GTRQIDDA 192
Cdd:cd15307  81 vlFCTASIMHLCTISVDRYLSLRYPMR---FGRNKTRRRVTLKIVFVWLLSiamslplSLMYSKDHASVLvnGTCQIPDP 157
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
45-143 2.07e-03

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 40.14  E-value: 2.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPC----VFVIGLLGNS--VSIYVLTRKrMRCTTNIYLTALAITDIAYLTcqlilSLQHYDYPKYHFKLYWQLygyfv 118
Cdd:cd15173   1 YFLPCmysvMFVTGLVGNSlvIVIYIFYEK-LRTLTDIFLVNLAVADLLFLC-----TLPFWAYSAAHEWIFGTV----- 69
                        90       100       110
                ....*....|....*....|....*....|..
gi 62473489 119 wLCDSFG-------YISIYIAVCFTIERFIAI 143
Cdd:cd15173  70 -MCKITNglytinlYSSMLILTCITVDRFIVI 100
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
45-176 2.22e-03

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 40.12  E-value: 2.22e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCVFVIGLLGNS-VSIYVLTRKRMRCTTNIYLTALAITDIAY-LTCQLILSLQHYDYPKYHF--KLYWQLYGYfvwl 120
Cdd:cd15172   5 VIYSLICVVGLIGNSlVVITYAFYKRTKSMTDVYLLNMAIADILFvLTLPFWAVYEAHQWIFGNFscKLLRGIYAI---- 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 62473489 121 cdSFgYISIYIAVCFTIERFIAIRYPLKRQTFCTESLA-KKVI-AAVAIFCLLSTLST 176
Cdd:cd15172  81 --NF-YSGMLLLACISVDRYIAIVQATKSFRLRSRTLAySKLIcAAVWLLAILISLPT 135
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
50-148 2.50e-03

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 40.16  E-value: 2.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTRK-RMRCTTNIYLTALAITDIAYLtCQLILSLQHYdypkyhfkLYWQLYGYFVWLCDSFGYI- 127
Cdd:cd15366  10 VIVLGLPTNCLALWAAYLQvRQRNELGVYLLNLSVSDLLYI-ATLPLWIDYF--------LHRDNWIHGPESCKLFGFIf 80
                        90       100
                ....*....|....*....|....*..
gi 62473489 128 --SIYIAV----CFTIERFIAIRYPLK 148
Cdd:cd15366  81 ytNIYISIaflcCISVDRYLAVAHPLR 107
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
358-486 2.61e-03

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 39.75  E-value: 2.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 358 LFTLLVFVVFPLLLLAtFNSILILLVHRSKNLRGDltnassiRRTKRKSnsglkgsvsqENRVTITLIAVVLMFIVCQLP 437
Cdd:cd15093 167 IYTFVLGFLLPLLIIC-LCYLLIVIKVKSAGLRAG-------WQQRKRS----------ERKVTRMVVMVVVVFVICWLP 228
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 62473489 438 WAIYLIVNQYMEIQIgTQVVAG--NVCNLLASLHAASNFFLYCVLSDKYRK 486
Cdd:cd15093 229 FYVLQLVNVFVQLPE-TPALVGvyHFVVILSYANSCANPILYGFLSDNFKK 278
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
45-165 2.64e-03

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 39.89  E-value: 2.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCVFVIGllGNSVSIYVLT-RKRMRCTTNIYLTALAITD----IAYLTCQLILSLQHYDYPkyhfkLYWQLYGYFVW 119
Cdd:cd15305   7 ILIIIILTIG--GNILVIMAVSlEKKLQNATNFFLMSLAVADmlvgILVMPVSLIAILYDYAWP-----LPRYLCPIWIS 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 62473489 120 LCDSFGYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAV 165
Cdd:cd15305  80 LDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAV 125
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
50-178 2.72e-03

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 39.85  E-value: 2.72e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLTRKR----MRCTTNIYLTALAITDIAYLTCQLILSLQHY---DYPKYHFKLYWQLYGYFVWLCd 122
Cdd:cd15356  10 IWALGAAGNALTIHLVLKKRslrgLQGTVHYHLVSLALSDLLILLISVPIELYNFvwfHYPWVFGDLVCRGYYFVRDIC- 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 62473489 123 sfGYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAF 178
Cdd:cd15356  89 --SYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALPMAF 142
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
45-182 2.90e-03

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 39.80  E-value: 2.90e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCVFVIGLLGNSVSIY-VLTRKRMRCTTNIYLTALAITDIA-YLTCQLILSLqhYDYPKYHFKLY-WQLYGYfvwLC 121
Cdd:cd15121   5 AILSLAFILGFPGNLFVVWsVLCRMKKRSVTCILVLNLALADAAvLLTAPFFLHF--LSGGGWEFGSVvCKLCHY---VC 79
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62473489 122 DSFGYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLSTAFEHTI 182
Cdd:cd15121  80 GVSMYASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLPMPFYRTV 140
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
45-165 3.26e-03

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 39.53  E-value: 3.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCVFVIGLLGNSVSIYVLT-RKRMRCTTNIYLTALAITD----IAYLTCQLILSLQHYDYPkyhfkLYWQLYGYFVW 119
Cdd:cd15304   5 LLTVIVIILTIAGNILVIMAVSlEKKLQNATNYFLMSLAIADmllgFLVMPVSMLTILYGYRWP-----LPSKLCAVWIY 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 62473489 120 LCDSFGYISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAV 165
Cdd:cd15304  80 LDVLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAV 125
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
50-154 3.69e-03

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 39.36  E-value: 3.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYV-LTRKRMRCTTNIYLTALAITDIAYLtCQLILSLQhydypkyhFKLYWQLYGYFVWLCDSFG--- 125
Cdd:cd15367  10 VLVVGLPANCLSLYYgYLQIKAKNELGIYLCNLTVADLLYI-FSLPFWLQ--------YVLQHDNWTYSELLCKICGill 80
                        90       100       110
                ....*....|....*....|....*....|...
gi 62473489 126 ----YISIYIAVCFTIERFIAIRYPLKRQTFCT 154
Cdd:cd15367  81 yeniYISIGFLCCISVDRYLAVVHPFRFHAFRT 113
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
52-174 3.80e-03

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 39.49  E-value: 3.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  52 VIGLLGN-SVSIYVLTRKRMRCTTNIYLTALAITDiayltcqLILSlqhydYPKYHFKLYWQLYGYFVW---LCDSFGYI 127
Cdd:cd15326  12 LFAIVGNiLVILSVVCNRHLRIPTNYFIVNLAIAD-------LLLS-----FTVLPFSATLEILGYWVFgriFCDIWAAV 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 62473489 128 -------SIYIAVCFTIERFIAIRYPLKRQTFCTEslaKKVIAAVAIFCLLSTL 174
Cdd:cd15326  80 dvlcctaSILSLCAISIDRYIGVRHSLQYPTIVTR---KRAILALLGVWVLSTV 130
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
45-101 3.84e-03

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 39.34  E-value: 3.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCVF----VIGLLGNSVSIYVLTRK-RMRCTTNIYLTALAITDIAY--------------------LTCQLILSLQH 99
Cdd:cd15087   1 VALPVIYsvicAVGLTGNTAVIYVILRApKMKTVTNVFILNLAIADDLFtlvlpiniaehllqqwpfgeLLCKLILSIDH 80

                ..
gi 62473489 100 YD 101
Cdd:cd15087  81 YN 82
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
50-145 5.65e-03

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 38.97  E-value: 5.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYV-LTRKRMRCTTNIYLTALAITD---IAYLTCQLILSLQHYDYPKYHFKLYwqlYGYFVWLCDSFG 125
Cdd:cd14987  10 IFVIGLLANSVVVWVnLQAKRTGYETHLYILNLAIADlcvVATLPVWVVSLVQHNQWPMGEFTCK---ITHLIFSINLFG 86
                        90       100
                ....*....|....*....|
gi 62473489 126 yiSIYIAVCFTIERFIAIRY 145
Cdd:cd14987  87 --SIFFLTCMSVDRYLSVTL 104
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
44-171 6.15e-03

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 38.74  E-value: 6.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  44 RILVPCVFVIGLLGNSVSIYVL--TRKRMRCT-------------TNIYLTALAITDIAyltcqlilSLQHYdypkYHFK 108
Cdd:cd15136   4 RIGVWFVFLLALVGNIIVLLVLltSRTKLTVPrflmcnlafadfcMGIYLGLLAIVDAK--------TLGEY----YNYA 71
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 109 LYWQlYGyfvWLCDSFGYI-------SIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLL 171
Cdd:cd15136  72 IDWQ-TG---AGCKTAGFLavfsselSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALI 137
7tmD_STE3 cd14966
fungal a-factor pheromone receptor STE3, member of the class D family of seven-transmembrane G ...
327-459 6.29e-03

fungal a-factor pheromone receptor STE3, member of the class D family of seven-transmembrane G protein-coupled receptors; This subfamily represents the a-factor pheromone receptor encoded by the STE3 gene, which is required for pheromone sensing and mating in haploid cells of the yeast Saccharomyces cerevisiae. The STE3-encoded seven-transmembrane domain receptor is a member of the class D GPCRs. Class D receptors are composed of two major subfamilies: Ste2 and Ste3. These two GPCRs (Ste2 and Ste3) sense the polypeptide mating pheromones, alpha-factor and a-factor, which activate a G protein-coupled receptors on the surface of the opposite yeast-mating haploid-types (MATa and MAT-alpha), respectively. Activation of these receptors by pheromones leads to activation of the mitogen-activated protein kinase (MAPK) signal transduction cascades, G1 cell cycle arrest, and polarized cell growth in the direction of the partner cell (a process called shmooing), which ultimately induces cell-cell fusion and the formation of a diploid zygote. Like all GPCRs, these pheromone mating factor receptors possess the same basic architecture of seven-transmembrane (7TM) domains and share common signaling mechanisms; however, there is no significant sequence similarity either between Ste2 and Ste3, or between these two receptors and the other 7TM GPCRs. Thus, STE2 and STE3 represent phylogenetically distinct groups.


Pssm-ID: 320097  Cd Length: 259  Bit Score: 38.64  E-value: 6.29e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 327 FNVTEY--CQNVTYynhglselgydelysylWNLFTLLVFVVFPLL--LLATFNSILIL--LVHRSKNLRGDLTNASSIR 400
Cdd:cd14966 135 YDIFEDvgCYPAIY-----------------NSWPALVLVYIWPLIisLIAAVYAVLTLrrFFRRRKQFRDLLSSSNSGL 197
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 62473489 401 RTKRKsnsglkgsvsqenrvtITLIAVVLMFIVCQLPWAIYLIVNQYMEIQIGTQVVAG 459
Cdd:cd14966 198 TTSRF----------------LRLMALALVEILITLPLSIYVLVLGSLELDRWIPVASA 240
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
396-486 6.73e-03

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 38.58  E-value: 6.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 396 ASSIRRTKRKSNSglkgsvsqenRVTITLIAVVLMFIVCQLPWAIYLIVNQYMEIQIGTQVVAGNVCNLLASL---HAAS 472
Cdd:cd14999 197 AASNSSRKRLPKQ----------KVLKMIFTIVLVFWACFLPFWIWQLLYLYSPSLSLSPRTTTYVNYLLTCLtysNSCI 266
                        90
                ....*....|....
gi 62473489 473 NFFLYCVLSDKYRK 486
Cdd:cd14999 267 NPFLYTLLTKNYKE 280
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
49-172 6.73e-03

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 38.43  E-value: 6.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  49 CVFVIGLLGNSVSIYVLTRKR-MRCTTNIYLTALAITDIAYLTCQLILSLQhydypkyhfkLYWQLYG------------ 115
Cdd:cd15221   9 SMYIVALLGNSLLLFVIVTERsLHEPMYLFLSMLAVTDLLLSTTTVPKMLA----------IFWFGAGeisfdgcltqmf 78
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62473489 116 --YFVWLCDSfgyiSIYIAVCFtiERFIAIRYPLKRQTFCTESLAKKVIAAVAI--FCLLS 172
Cdd:cd15221  79 fvHFVFVTES----AILLAMAF--DRYVAICYPLRYTTILTHSVIGKIGVAAVArsFCIVF 133
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
46-174 7.35e-03

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 38.58  E-value: 7.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  46 LVPC----VFVIGLLGNSVSIYVLTRKRMRCTTNIYLTALAITDiayltCQLILSLQhydyPK--YHFK-LYWQLYGYFV 118
Cdd:cd15372   2 LVPSlytlVFLVGLPANGLALWVLATQVKRLPSTIFLINLAVAD-----LLLILVLP----FKisYHFLgNNWPFGEGLC 72
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489 119 WLCDSFGYISIYIAV----CFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTL 174
Cdd:cd15372  73 RVVTAFFYGNMYCSVlllmCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTL 132
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
50-148 7.61e-03

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 38.35  E-value: 7.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  50 VFVIGLLGNSVSIYVLT-RKRMRCTTNIYLTALAITDIAYLTCQLILSLQHYDYPKYHFKLYWQLYGYFVWLCDSFGyiS 128
Cdd:cd15377  10 VFITGFLGNSVAIWMFVfHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYG--S 87
                        90       100
                ....*....|....*....|
gi 62473489 129 IYIAVCFTIERFIAIRYPLK 148
Cdd:cd15377  88 ILFLTCISVHRYTGVVHPLK 107
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
45-176 8.21e-03

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 38.24  E-value: 8.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPCVFviGLLGN--SVSIYVLTRKRMRcTTNIYLTALAITDIAYLTCQLILS---LQHYDYPKYHFklywqlygyfvw 119
Cdd:cd15380   7 IIAICFF--GLLGNlfVLFVFLLPRRRLT-IAEIYLANLAASDLVFVLGLPFWAeniRNQFNWPFGNF------------ 71
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62473489 120 LCDSFG-------YISIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAVAIFCLLSTLST 176
Cdd:cd15380  72 LCRVISgvikanlFISIFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIPT 135
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
45-165 9.10e-03

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 38.20  E-value: 9.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62473489  45 ILVPC----VFVIGLLGNSVSIYV-LTRKRMRCTTNIYLTALAITDIAYLtcqLILSLQHYDYPK-------------YH 106
Cdd:cd15373   1 ILLPVsygiVFVVGLVLNILALYVfLFRTKPWNASTTYMFNLAISDTLYV---LSLPLLVYYYADendwpfsealckiVR 77
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 62473489 107 FKLYWQLYGyfvwlcdsfgyiSIYIAVCFTIERFIAIRYPLKRQTFCTESLAKKVIAAV 165
Cdd:cd15373  78 FLFYTNLYC------------SILFLLCISVHRFLGVCYPVRSLRWLKVRYARIVSVVV 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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