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Conserved domains on  [gi|2123767723|ref|NP_001026270|]
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centromere protein O [Gallus gallus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DRWD-C_CENP-O cd23836
C-terminal double-RWD domain of centromere protein O (CENP-O) and related proteins; CENP-O, ...
 217-317 1.08e-32

C-terminal double-RWD domain of centromere protein O (CENP-O) and related proteins; CENP-O, also called interphase centromere complex protein 36 (ICEN36), or MCM21R, is a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression, and chromosome segregation. It may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. It modulates the kinetochore-bound levels of NDC80 complex. CENP-O contains two RWD domains, also known as a double-RWD domain, DRWD, which is involved in interactions with other kinetochore proteins. The model corresponds to the C-terminal double-RWD domain (DRWD-C).


:

Pssm-ID: 467669  Cd Length: 98  Bit Score: 116.63  E-value: 1.08e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123767723 217 NAYVGRRHQADQLEEHFSDHIdGTLQRNSLCNLLVFNYTVSSNSktFPFNVRLLYGDLCCSLPTEAIISCTPGTLPLLAE 296
Cdd:cd23836     1 NAYVSRREQVDQLKELFGEFV-GEIEHSSAYDFISFSLKVSTGS--GRFEVTLKYDDLTSELPTEVTVTCTDKESSSSEE 77

                          90       100
                  ....*....|....*....|.
gi 2123767723 297 MAAAHSNAFRHMALHKAFDSL 317
Cdd:cd23836    78 QLSKHESLFRTNPLHDALAEI 98
DRWD-N_CENP-O cd23835
N-terminal double-RWD domain of centromere protein O (CENP-O) and related proteins; CENP-O, ...
 136-216 2.11e-32

N-terminal double-RWD domain of centromere protein O (CENP-O) and related proteins; CENP-O, also called interphase centromere complex protein 36 (ICEN36), or MCM21R, is a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression, and chromosome segregation. It may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. It modulates the kinetochore-bound levels of NDC80 complex. CENP-O contains two RWD domains, also known as a double-RWD domain, DRWD, which is involved in interactions with other kinetochore proteins. The model corresponds to the N-terminal double-RWD domain (DRWD-N).


:

Pssm-ID: 467668  Cd Length: 86  Bit Score: 115.76  E-value: 2.11e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123767723 136 MLQVFYLTGISGKLTK-QGVCFCISTAYEGTYLDSYYVDLLIKP--LVKIQRHSVPVFIPLEQIAKKYLQTDIRRFLSVL 212
Cdd:cd23835     3 LLQAYRLTGRSVFEVDgNRLGVRFDTFYEGTYLESYYIDLEIKSplSLKISRHTLPYFIPLEELEKKYLQTDLKKFLSVV 82


                  ....
gi 2123767723 213 SDHL 216
Cdd:cd23835    83 SEYL 86
DASH_Spc19 super family cl07046
Spc19; Spc19 is a component of the DASH complex. The DASH complex associates with the spindle ...
 79-120 6.74e-03

Spc19; Spc19 is a component of the DASH complex. The DASH complex associates with the spindle pole body and is important for spindle and kinetochore integrity during cell division.


The actual alignment was detected with superfamily member pfam08287:

Pssm-ID: 429900 [Multi-domain]  Cd Length: 148  Bit Score: 36.46  E-value: 6.74e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2123767723  79 LDRLKARVQELRARRDELRAKVELQEKRLLDKEGVMADPAQP 120
Cdd:pfam08287  68 LDKAEKSLEKLERREETLKAKLELNEGRLSNAESSARDEEGS 109
 
Name Accession Description Interval E-value
DRWD-C_CENP-O cd23836
C-terminal double-RWD domain of centromere protein O (CENP-O) and related proteins; CENP-O, ...
 217-317 1.08e-32

C-terminal double-RWD domain of centromere protein O (CENP-O) and related proteins; CENP-O, also called interphase centromere complex protein 36 (ICEN36), or MCM21R, is a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression, and chromosome segregation. It may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. It modulates the kinetochore-bound levels of NDC80 complex. CENP-O contains two RWD domains, also known as a double-RWD domain, DRWD, which is involved in interactions with other kinetochore proteins. The model corresponds to the C-terminal double-RWD domain (DRWD-C).


Pssm-ID: 467669  Cd Length: 98  Bit Score: 116.63  E-value: 1.08e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123767723 217 NAYVGRRHQADQLEEHFSDHIdGTLQRNSLCNLLVFNYTVSSNSktFPFNVRLLYGDLCCSLPTEAIISCTPGTLPLLAE 296
Cdd:cd23836     1 NAYVSRREQVDQLKELFGEFV-GEIEHSSAYDFISFSLKVSTGS--GRFEVTLKYDDLTSELPTEVTVTCTDKESSSSEE 77

                          90       100
                  ....*....|....*....|.
gi 2123767723 297 MAAAHSNAFRHMALHKAFDSL 317
Cdd:cd23836    78 QLSKHESLFRTNPLHDALAEI 98
DRWD-N_CENP-O cd23835
N-terminal double-RWD domain of centromere protein O (CENP-O) and related proteins; CENP-O, ...
 136-216 2.11e-32

N-terminal double-RWD domain of centromere protein O (CENP-O) and related proteins; CENP-O, also called interphase centromere complex protein 36 (ICEN36), or MCM21R, is a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression, and chromosome segregation. It may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. It modulates the kinetochore-bound levels of NDC80 complex. CENP-O contains two RWD domains, also known as a double-RWD domain, DRWD, which is involved in interactions with other kinetochore proteins. The model corresponds to the N-terminal double-RWD domain (DRWD-N).


Pssm-ID: 467668  Cd Length: 86  Bit Score: 115.76  E-value: 2.11e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123767723 136 MLQVFYLTGISGKLTK-QGVCFCISTAYEGTYLDSYYVDLLIKP--LVKIQRHSVPVFIPLEQIAKKYLQTDIRRFLSVL 212
Cdd:cd23835     3 LLQAYRLTGRSVFEVDgNRLGVRFDTFYEGTYLESYYIDLEIKSplSLKISRHTLPYFIPLEELEKKYLQTDLKKFLSVV 82


                  ....
gi 2123767723 213 SDHL 216
Cdd:cd23835    83 SEYL 86
CENP-O pfam09496
Cenp-O kinetochore centromere component; This eukaryotic protein is a component of the inner ...
 153-240 5.66e-11

Cenp-O kinetochore centromere component; This eukaryotic protein is a component of the inner kinetochore subcomplex of the centromere. It has been shown to be involved in chromosome segregation via regulation of the spindle in both yeast and human.


Pssm-ID: 430646 [Multi-domain]  Cd Length: 202  Bit Score: 61.10  E-value: 5.66e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123767723 153 GVCFCISTAyeGTYLDSYYVdLLIKP-----LVKIQRHSVPVFIPLEQIAKKYLQT--------------DIRRFLSVLS 213
Cdd:pfam09496  21 GIRIDVSSR--GRFLRPYYV-LLNRPsfgekRLRVHRHTIPPFIPLSGLAARYLPApeeakkdkektpkqDLVRFVRELR 97

                          90       100
                  ....*....|....*....|....*..
gi 2123767723 214 DHLNAYVGRRHQADQLEEHFSDHIDGT 240
Cdd:pfam09496  98 RELVAYHNRLDAVRDLREALGLQDKEL 124
DASH_Spc19 pfam08287
Spc19; Spc19 is a component of the DASH complex. The DASH complex associates with the spindle ...
 79-120 6.74e-03

Spc19; Spc19 is a component of the DASH complex. The DASH complex associates with the spindle pole body and is important for spindle and kinetochore integrity during cell division.


Pssm-ID: 429900 [Multi-domain]  Cd Length: 148  Bit Score: 36.46  E-value: 6.74e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2123767723  79 LDRLKARVQELRARRDELRAKVELQEKRLLDKEGVMADPAQP 120
Cdd:pfam08287  68 LDKAEKSLEKLERREETLKAKLELNEGRLSNAESSARDEEGS 109
 
Name Accession Description Interval E-value
DRWD-C_CENP-O cd23836
C-terminal double-RWD domain of centromere protein O (CENP-O) and related proteins; CENP-O, ...
 217-317 1.08e-32

C-terminal double-RWD domain of centromere protein O (CENP-O) and related proteins; CENP-O, also called interphase centromere complex protein 36 (ICEN36), or MCM21R, is a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression, and chromosome segregation. It may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. It modulates the kinetochore-bound levels of NDC80 complex. CENP-O contains two RWD domains, also known as a double-RWD domain, DRWD, which is involved in interactions with other kinetochore proteins. The model corresponds to the C-terminal double-RWD domain (DRWD-C).


Pssm-ID: 467669  Cd Length: 98  Bit Score: 116.63  E-value: 1.08e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123767723 217 NAYVGRRHQADQLEEHFSDHIdGTLQRNSLCNLLVFNYTVSSNSktFPFNVRLLYGDLCCSLPTEAIISCTPGTLPLLAE 296
Cdd:cd23836     1 NAYVSRREQVDQLKELFGEFV-GEIEHSSAYDFISFSLKVSTGS--GRFEVTLKYDDLTSELPTEVTVTCTDKESSSSEE 77

                          90       100
                  ....*....|....*....|.
gi 2123767723 297 MAAAHSNAFRHMALHKAFDSL 317
Cdd:cd23836    78 QLSKHESLFRTNPLHDALAEI 98
DRWD-N_CENP-O cd23835
N-terminal double-RWD domain of centromere protein O (CENP-O) and related proteins; CENP-O, ...
 136-216 2.11e-32

N-terminal double-RWD domain of centromere protein O (CENP-O) and related proteins; CENP-O, also called interphase centromere complex protein 36 (ICEN36), or MCM21R, is a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression, and chromosome segregation. It may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. It modulates the kinetochore-bound levels of NDC80 complex. CENP-O contains two RWD domains, also known as a double-RWD domain, DRWD, which is involved in interactions with other kinetochore proteins. The model corresponds to the N-terminal double-RWD domain (DRWD-N).


Pssm-ID: 467668  Cd Length: 86  Bit Score: 115.76  E-value: 2.11e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123767723 136 MLQVFYLTGISGKLTK-QGVCFCISTAYEGTYLDSYYVDLLIKP--LVKIQRHSVPVFIPLEQIAKKYLQTDIRRFLSVL 212
Cdd:cd23835     3 LLQAYRLTGRSVFEVDgNRLGVRFDTFYEGTYLESYYIDLEIKSplSLKISRHTLPYFIPLEELEKKYLQTDLKKFLSVV 82


                  ....
gi 2123767723 213 SDHL 216
Cdd:cd23835    83 SEYL 86
CENP-O pfam09496
Cenp-O kinetochore centromere component; This eukaryotic protein is a component of the inner ...
 153-240 5.66e-11

Cenp-O kinetochore centromere component; This eukaryotic protein is a component of the inner kinetochore subcomplex of the centromere. It has been shown to be involved in chromosome segregation via regulation of the spindle in both yeast and human.


Pssm-ID: 430646 [Multi-domain]  Cd Length: 202  Bit Score: 61.10  E-value: 5.66e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2123767723 153 GVCFCISTAyeGTYLDSYYVdLLIKP-----LVKIQRHSVPVFIPLEQIAKKYLQT--------------DIRRFLSVLS 213
Cdd:pfam09496  21 GIRIDVSSR--GRFLRPYYV-LLNRPsfgekRLRVHRHTIPPFIPLSGLAARYLPApeeakkdkektpkqDLVRFVRELR 97

                          90       100
                  ....*....|....*....|....*..
gi 2123767723 214 DHLNAYVGRRHQADQLEEHFSDHIDGT 240
Cdd:pfam09496  98 RELVAYHNRLDAVRDLREALGLQDKEL 124
DRWD-N_Mcm21 cd23830
N-terminal double-RWD domain of minichromosome maintenance protein 21 (MCM21) and related ...
 184-212 1.19e-03

N-terminal double-RWD domain of minichromosome maintenance protein 21 (MCM21) and related proteins; MCM21, also called inner kinetochore subunit MCM21, CENP-O homolog, chromosome transmission fidelity protein 5 (CTF5), or constitutive centromere-associated network protein MCM21, is a component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. MCM21 contains two RWD domains, also known as a double-RWD domain, DRWD, which is involved in interactions with other kinetochore proteins. The model corresponds to the N-terminal double-RWD domain (DRWD-N).


Pssm-ID: 467664  Cd Length: 107  Bit Score: 37.75  E-value: 1.19e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2123767723 184 RHSVPVFIPLEQIAKKYL------QTDIRRFLSVL 212
Cdd:cd23830    73 KHTIPAFIPVQGLADRYLggtdpsKDDLRLFAREL 107
DASH_Spc19 pfam08287
Spc19; Spc19 is a component of the DASH complex. The DASH complex associates with the spindle ...
 79-120 6.74e-03

Spc19; Spc19 is a component of the DASH complex. The DASH complex associates with the spindle pole body and is important for spindle and kinetochore integrity during cell division.


Pssm-ID: 429900 [Multi-domain]  Cd Length: 148  Bit Score: 36.46  E-value: 6.74e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 2123767723  79 LDRLKARVQELRARRDELRAKVELQEKRLLDKEGVMADPAQP 120
Cdd:pfam08287  68 LDKAEKSLEKLERREETLKAKLELNEGRLSNAESSARDEEGS 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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