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Conserved domains on  [gi|85701672|ref|NP_001028334|]
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testicular spindle-associated protein SHCBP1L [Mus musculus]

Protein Classification

right-handed parallel beta-helix repeat-containing protein( domain architecture ID 12131601)

right-handed parallel beta-helix repeat-containing protein that may share some similarity with pectate lyases, similar to Bacteroides thetaiotaomicron alpha-1,3-galactosidase B that removes both branched alpha-1,3-linked galactose residues of blood group B antigens and linear alpha-1,3-linked galactose structures

PubMed:  38767844

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 472-580 4.54e-16

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


:

Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 75.91  E-value: 4.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701672   472 DGIVVVESGHLTLENC-LLKCEGTGVCVLTGASLTITNSEITGAQGAGVELYPGSIAILEGNEIHHCNN--LRTSDSSKS 548
Cdd:pfam13229   1 SGILLNGSSNATIKNNtISNNGGYGIYLRGSSNATIENNTITNNGGDGIEISGSSNNTISNNTISNNGGggIALRGSSNN 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 85701672   549 TL--------GGVNMKVLPAPKLKMTNNHIYNNNGYGVSI 580
Cdd:pfam13229  81 LIenntisnnGGAGIYLSDSSNNTIENNIIHNNGGSGIVI 120
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 494-639 2.41e-05

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


:

Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 45.09  E-value: 2.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701672   494 TGVCVLTGASLTITNSEITGAQGAGVELYPGSIAILEGNEIHhcnnlrtsdsskstlggvnmkvlpapklkmtnnhiyNN 573
Cdd:pfam13229   1 SGILLNGSSNATIKNNTISNNGGYGIYLRGSSNATIENNTIT------------------------------------NN 44

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 85701672   574 NGYGVSILQPSEQFFIVAEAALNKGAAsgdkkddkmlSKVMQTLNVEMNNNRIEANLKGDIRIVTG 639
Cdd:pfam13229  45 GGDGIEISGSSNNTISNNTISNNGGGG----------IALRGSSNNLIENNTISNNGGAGIYLSDS 100
 
Name Accession Description Interval E-value
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 472-580 4.54e-16

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 75.91  E-value: 4.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701672   472 DGIVVVESGHLTLENC-LLKCEGTGVCVLTGASLTITNSEITGAQGAGVELYPGSIAILEGNEIHHCNN--LRTSDSSKS 548
Cdd:pfam13229   1 SGILLNGSSNATIKNNtISNNGGYGIYLRGSSNATIENNTITNNGGDGIEISGSSNNTISNNTISNNGGggIALRGSSNN 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 85701672   549 TL--------GGVNMKVLPAPKLKMTNNHIYNNNGYGVSI 580
Cdd:pfam13229  81 LIenntisnnGGAGIYLSDSSNNTIENNIIHNNGGSGIVI 120
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 391-580 3.65e-10

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 61.86  E-value: 3.65e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701672 391 QQHNDLNLALDSCYSGDIVVIFPGEYqASNLaLLTDDITIKGVGKreeIMITSEPSHDSFVVsKADNVKLMQLSLIQQGT 470
Cdd:COG3420  19 APGDSLQAAIDAAPPGDTIEVPPGTY-EGNI-VIDKPLTLIGEGG---AVIDGGGKGTVITI-TADNVTVRGLTITGSGD 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701672 471 VD-----GIVVVESGHLTLENCLLKCEGTGVCVLTGASLTITNSEITGAQ------GAGVELYPGSIAILEGNEI----- 534
Cdd:COG3420  93 SLtdddaGIYVRGADNAVIENNRIENNLFGIYLEGSDNNVIRNNTISGNRdlradrGNGIHLWNSPGNVIEGNTIsggrd 172

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 85701672 535 -------HHC-------NNLR-------TSDS------SKSTLGGVnmKVLPAPKLKMTNNHIYNNNGYGVSI 580
Cdd:COG3420 173 giylefsDNNvirnntiRNLRygihymySNDNlvegntFRDNGAGI--ALMYSKGNTVRGNTILGNSGYGILL 243
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 494-639 2.41e-05

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 45.09  E-value: 2.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701672   494 TGVCVLTGASLTITNSEITGAQGAGVELYPGSIAILEGNEIHhcnnlrtsdsskstlggvnmkvlpapklkmtnnhiyNN 573
Cdd:pfam13229   1 SGILLNGSSNATIKNNTISNNGGYGIYLRGSSNATIENNTIT------------------------------------NN 44

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 85701672   574 NGYGVSILQPSEQFFIVAEAALNKGAAsgdkkddkmlSKVMQTLNVEMNNNRIEANLKGDIRIVTG 639
Cdd:pfam13229  45 GGDGIEISGSSNNTISNNTISNNGGGG----------IALRGSSNNLIENNTISNNGGAGIYLSDS 100
 
Name Accession Description Interval E-value
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 472-580 4.54e-16

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 75.91  E-value: 4.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701672   472 DGIVVVESGHLTLENC-LLKCEGTGVCVLTGASLTITNSEITGAQGAGVELYPGSIAILEGNEIHHCNN--LRTSDSSKS 548
Cdd:pfam13229   1 SGILLNGSSNATIKNNtISNNGGYGIYLRGSSNATIENNTITNNGGDGIEISGSSNNTISNNTISNNGGggIALRGSSNN 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 85701672   549 TL--------GGVNMKVLPAPKLKMTNNHIYNNNGYGVSI 580
Cdd:pfam13229  81 LIenntisnnGGAGIYLSDSSNNTIENNIIHNNGGSGIVI 120
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 443-581 5.49e-12

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 63.97  E-value: 5.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701672   443 SEPSHDSFVVSKADNVkLMQLSLIQQGTVDGIVVVESGHLTLENCLLK-CEGTGVCVLTGASLTITNSEITGAQGAGVEL 521
Cdd:pfam13229  19 SNNGGYGIYLRGSSNA-TIENNTITNNGGDGIEISGSSNNTISNNTISnNGGGGIALRGSSNNLIENNTISNNGGAGIYL 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701672   522 YPGSIAILEGNEIHHCNNlrtsdsskstlGGVNMKVLpAPKLKMTNNHIYNNNGYGVSIL 581
Cdd:pfam13229  98 SDSSNNTIENNIIHNNGG-----------SGIVIEDS-SNNVTISNNTVTNNKGAGILIV 145
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 391-580 3.65e-10

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 61.86  E-value: 3.65e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701672 391 QQHNDLNLALDSCYSGDIVVIFPGEYqASNLaLLTDDITIKGVGKreeIMITSEPSHDSFVVsKADNVKLMQLSLIQQGT 470
Cdd:COG3420  19 APGDSLQAAIDAAPPGDTIEVPPGTY-EGNI-VIDKPLTLIGEGG---AVIDGGGKGTVITI-TADNVTVRGLTITGSGD 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701672 471 VD-----GIVVVESGHLTLENCLLKCEGTGVCVLTGASLTITNSEITGAQ------GAGVELYPGSIAILEGNEI----- 534
Cdd:COG3420  93 SLtdddaGIYVRGADNAVIENNRIENNLFGIYLEGSDNNVIRNNTISGNRdlradrGNGIHLWNSPGNVIEGNTIsggrd 172

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 85701672 535 -------HHC-------NNLR-------TSDS------SKSTLGGVnmKVLPAPKLKMTNNHIYNNNGYGVSI 580
Cdd:COG3420 173 giylefsDNNvirnntiRNLRygihymySNDNlvegntFRDNGAGI--ALMYSKGNTVRGNTILGNSGYGILL 243
NosD pfam05048
Periplasmic copper-binding protein (NosD); NosD is a periplasmic protein which is thought to ...
 405-581 1.45e-07

Periplasmic copper-binding protein (NosD); NosD is a periplasmic protein which is thought to insert copper into the exported reductase apoenzyme (NosZ). This region forms a parallel beta helix domain.


Pssm-ID: 428281 [Multi-domain]  Cd Length: 215  Bit Score: 52.42  E-value: 1.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701672   405 SGDIVVIFPGEYqasnlalLTDDITIKGVGKREEIMITSEPSHDSFVVSKADNVKLMQLSLiqQGTVDGIVVVESGHLTL 484
Cdd:pfam05048   6 SGDTIGIYNGLS-------RGNGIQLWNTEGNVISNNDIINSRDGIYLDASNNNTITGNRI--SNLRYGIHLMNSNDNTI 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701672   485 ENCLLKCEGTGVCVLTGASLTITNSEITGAQGAGVELYPGSIAILEGNEIHHCNN--LRTSDSSKSTLggvnmkvlpapk 562
Cdd:pfam05048  77 SDNVFSGNTAGIALMSSSNNTLENNTISGNTNYGILLSDSSNNTISNNTISNNNGkgIFLYNSDYNTI------------ 144

                         170
                  ....*....|....*....
gi 85701672   563 lkmTNNHIYnNNGYGVSIL 581
Cdd:pfam05048 145 ---TGNRIT-SNGIGIHFL 159
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 494-639 2.41e-05

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 45.09  E-value: 2.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701672   494 TGVCVLTGASLTITNSEITGAQGAGVELYPGSIAILEGNEIHhcnnlrtsdsskstlggvnmkvlpapklkmtnnhiyNN 573
Cdd:pfam13229   1 SGILLNGSSNATIKNNTISNNGGYGIYLRGSSNATIENNTIT------------------------------------NN 44

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 85701672   574 NGYGVSILQPSEQFFIVAEAALNKGAAsgdkkddkmlSKVMQTLNVEMNNNRIEANLKGDIRIVTG 639
Cdd:pfam13229  45 GGDGIEISGSSNNTISNNTISNNGGGG----------IALRGSSNNLIENNTISNNGGAGIYLSDS 100
NosD COG3420
Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion ...
 473-585 3.35e-05

Nitrous oxide reductase accessory protein NosD, contains tandem CASH domains [Inorganic ion transport and metabolism];


Pssm-ID: 442646 [Multi-domain]  Cd Length: 343  Bit Score: 46.45  E-value: 3.35e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 85701672 473 GIVVVESGHLTLENCLLKCEGTGVCVLTGASLTITNSEITGAQGAGVELYPGSIAILEGNEIHHCNN-LRTSDSSKSTLg 551
Cdd:COG3420 195 GIHYMYSNDNLVEGNTFRDNGAGIALMYSKGNTVRGNTILGNSGYGILLKESSDSVIEGNTISGNGKgIFIYNSNRNTI- 273

                        90       100       110
                ....*....|....*....|....*....|....
gi 85701672 552 gvnmkvlpapklkmTNNHIYnNNGYGVSILQPSE 585
Cdd:COG3420 274 --------------RGNLFA-GNGIGIHLTAGSE 292
Beta_helix pfam13229
Right handed beta helix region; This region contains a parallel beta helix region that shares ...
 472-534 1.79e-04

Right handed beta helix region; This region contains a parallel beta helix region that shares some similarity with Pectate lyases.


Pssm-ID: 463811 [Multi-domain]  Cd Length: 158  Bit Score: 42.39  E-value: 1.79e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 85701672   472 DGIVVVESGHLTLENCLLK-CEGTGVCVLTGAS-LTITNSEITGAQGAGVELYPGS-IAILEGNEI 534
Cdd:pfam13229  93 AGIYLSDSSNNTIENNIIHnNGGSGIVIEDSSNnVTISNNTVTNNKGAGILIVGGSsNNTVENNTF 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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