NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|87299630|ref|NP_001034610|]
View 

RNA polymerase I-specific transcription initiation factor RRN3 [Mus musculus]

Protein Classification

RNA polymerase I-specific transcription initiation factor RRN3 family protein( domain architecture ID 10526375)

RNA polymerase I-specific transcription initiation factor RRN3 family protein similar to human RRN3 that is required for efficient transcription initiation by RNA polymerase I, and for the formation of the competent preinitiation complex (PIC).

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RRN3 pfam05327
RNA polymerase I specific transcription initiation factor RRN3; This family consists of ...
 58-581 6.72e-141

RNA polymerase I specific transcription initiation factor RRN3; This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.


:

Pssm-ID: 461623  Cd Length: 548  Bit Score: 422.02  E-value: 6.72e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87299630    58 LLKYKKGETNDLELLKNQLS-DPD----IKDDQIINWLLEFRSSVMYLTKDFEQLINIILRLPWLNRSQRVVEEYLAFLG 132
Cdd:pfam05327  16 LEEHEKGDSEQYDELKEQFSpDPEspdaPSTALLKQLLKALSSNVSRLDRSCSGLVEAILSLSWLGRDESFVKAYIRFLG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87299630   133 NLVSAQTVFLRPCLSMIASHFVPPRVIvkeggiDVSDSDDEDDNLPAIFDTCHRALQIITRYVPSTPWFLMPILVEKFPF 212
Cdd:pfam05327  96 VLASAHPKYLSLVLSMLVSNFTPQPES------SGRLPGYPPVTRREVYERVHEALKYILRLIPTAPSVLLPILSRKFPH 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87299630   213 VRKSERTLECYVHNLLRISLYFPTLRREILELVIEKLLKLDVS--VSRQDIED-AEEKAAQTCGGTDTTEGLFNMDEDED 289
Cdd:pfam05327 170 KRDSKKAQVTYIRNLLRLTEYCPELGSDILALIIERLIKIDVEiqVELEDLDDdEDEELLEQLDEDDDDDDDDDSDDDSD 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87299630   290 TDPEKKADQEQPN-----QMAHPTAERLDVLLCLLLSYIEDVCR--VHGKIDNNKTKDLYRDLISIFDKLLLPTHASCHV 362
Cdd:pfam05327 250 SSDDGLDDDEEDDevqriKKIKELVEKLDAILDLLFEHLDSKFSsgSPEELNEGEGVEVFNTLLSLFKSTILPTYRSRHT 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87299630   363 QFFMFFLCSFKLGFAEAFLEHLWKKLQDPNNPAIIRQAAANYIGSFLARAKFIPLITVKTCLDLLVNWLHMYLTNQDSGT 442
Cdd:pfam05327 330 QFLLFHFSQLSPELMDSFLGTLIDIAFDPNEPAITRQAAAAYLASFVARAKFVSRSQVRFVLSYLCDWLNRYVDEREEEC 409

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87299630   443 KAfCDVALHGPFYSACQAVFYTVVFRHKQLL---SGNLKQGLQYLQSLN--FERIVLSQLNPLKICLPQVVNFFAAITNK 517
Cdd:pfam05327 410 RG-PDLKRHGVFYAVCQALLYIFCFRWRDLTdadDDEEGGDLEWLPGLDefLQRAIYSKLNPLKVCSPNVVTEFARIAHH 488

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 87299630   518 YQLVFCYTIMERNSRqmlpviRSTAGGDSVQTcTNPLDTFFPFDPCVLKRSKKFIDPIYQIWED 581
Cdd:pfam05327 489 LQFAYCFSIIESNKR------EETAGTATGQE-FEQLDAYFPFDPYLLPRSKRWIEPDYVEWSE 545
 
Name Accession Description Interval E-value
RRN3 pfam05327
RNA polymerase I specific transcription initiation factor RRN3; This family consists of ...
 58-581 6.72e-141

RNA polymerase I specific transcription initiation factor RRN3; This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.


Pssm-ID: 461623  Cd Length: 548  Bit Score: 422.02  E-value: 6.72e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87299630    58 LLKYKKGETNDLELLKNQLS-DPD----IKDDQIINWLLEFRSSVMYLTKDFEQLINIILRLPWLNRSQRVVEEYLAFLG 132
Cdd:pfam05327  16 LEEHEKGDSEQYDELKEQFSpDPEspdaPSTALLKQLLKALSSNVSRLDRSCSGLVEAILSLSWLGRDESFVKAYIRFLG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87299630   133 NLVSAQTVFLRPCLSMIASHFVPPRVIvkeggiDVSDSDDEDDNLPAIFDTCHRALQIITRYVPSTPWFLMPILVEKFPF 212
Cdd:pfam05327  96 VLASAHPKYLSLVLSMLVSNFTPQPES------SGRLPGYPPVTRREVYERVHEALKYILRLIPTAPSVLLPILSRKFPH 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87299630   213 VRKSERTLECYVHNLLRISLYFPTLRREILELVIEKLLKLDVS--VSRQDIED-AEEKAAQTCGGTDTTEGLFNMDEDED 289
Cdd:pfam05327 170 KRDSKKAQVTYIRNLLRLTEYCPELGSDILALIIERLIKIDVEiqVELEDLDDdEDEELLEQLDEDDDDDDDDDSDDDSD 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87299630   290 TDPEKKADQEQPN-----QMAHPTAERLDVLLCLLLSYIEDVCR--VHGKIDNNKTKDLYRDLISIFDKLLLPTHASCHV 362
Cdd:pfam05327 250 SSDDGLDDDEEDDevqriKKIKELVEKLDAILDLLFEHLDSKFSsgSPEELNEGEGVEVFNTLLSLFKSTILPTYRSRHT 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87299630   363 QFFMFFLCSFKLGFAEAFLEHLWKKLQDPNNPAIIRQAAANYIGSFLARAKFIPLITVKTCLDLLVNWLHMYLTNQDSGT 442
Cdd:pfam05327 330 QFLLFHFSQLSPELMDSFLGTLIDIAFDPNEPAITRQAAAAYLASFVARAKFVSRSQVRFVLSYLCDWLNRYVDEREEEC 409

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87299630   443 KAfCDVALHGPFYSACQAVFYTVVFRHKQLL---SGNLKQGLQYLQSLN--FERIVLSQLNPLKICLPQVVNFFAAITNK 517
Cdd:pfam05327 410 RG-PDLKRHGVFYAVCQALLYIFCFRWRDLTdadDDEEGGDLEWLPGLDefLQRAIYSKLNPLKVCSPNVVTEFARIAHH 488

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 87299630   518 YQLVFCYTIMERNSRqmlpviRSTAGGDSVQTcTNPLDTFFPFDPCVLKRSKKFIDPIYQIWED 581
Cdd:pfam05327 489 LQFAYCFSIIESNKR------EETAGTATGQE-FEQLDAYFPFDPYLLPRSKRWIEPDYVEWSE 545
 
Name Accession Description Interval E-value
RRN3 pfam05327
RNA polymerase I specific transcription initiation factor RRN3; This family consists of ...
 58-581 6.72e-141

RNA polymerase I specific transcription initiation factor RRN3; This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.


Pssm-ID: 461623  Cd Length: 548  Bit Score: 422.02  E-value: 6.72e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87299630    58 LLKYKKGETNDLELLKNQLS-DPD----IKDDQIINWLLEFRSSVMYLTKDFEQLINIILRLPWLNRSQRVVEEYLAFLG 132
Cdd:pfam05327  16 LEEHEKGDSEQYDELKEQFSpDPEspdaPSTALLKQLLKALSSNVSRLDRSCSGLVEAILSLSWLGRDESFVKAYIRFLG 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87299630   133 NLVSAQTVFLRPCLSMIASHFVPPRVIvkeggiDVSDSDDEDDNLPAIFDTCHRALQIITRYVPSTPWFLMPILVEKFPF 212
Cdd:pfam05327  96 VLASAHPKYLSLVLSMLVSNFTPQPES------SGRLPGYPPVTRREVYERVHEALKYILRLIPTAPSVLLPILSRKFPH 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87299630   213 VRKSERTLECYVHNLLRISLYFPTLRREILELVIEKLLKLDVS--VSRQDIED-AEEKAAQTCGGTDTTEGLFNMDEDED 289
Cdd:pfam05327 170 KRDSKKAQVTYIRNLLRLTEYCPELGSDILALIIERLIKIDVEiqVELEDLDDdEDEELLEQLDEDDDDDDDDDSDDDSD 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87299630   290 TDPEKKADQEQPN-----QMAHPTAERLDVLLCLLLSYIEDVCR--VHGKIDNNKTKDLYRDLISIFDKLLLPTHASCHV 362
Cdd:pfam05327 250 SSDDGLDDDEEDDevqriKKIKELVEKLDAILDLLFEHLDSKFSsgSPEELNEGEGVEVFNTLLSLFKSTILPTYRSRHT 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87299630   363 QFFMFFLCSFKLGFAEAFLEHLWKKLQDPNNPAIIRQAAANYIGSFLARAKFIPLITVKTCLDLLVNWLHMYLTNQDSGT 442
Cdd:pfam05327 330 QFLLFHFSQLSPELMDSFLGTLIDIAFDPNEPAITRQAAAAYLASFVARAKFVSRSQVRFVLSYLCDWLNRYVDEREEEC 409

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 87299630   443 KAfCDVALHGPFYSACQAVFYTVVFRHKQLL---SGNLKQGLQYLQSLN--FERIVLSQLNPLKICLPQVVNFFAAITNK 517
Cdd:pfam05327 410 RG-PDLKRHGVFYAVCQALLYIFCFRWRDLTdadDDEEGGDLEWLPGLDefLQRAIYSKLNPLKVCSPNVVTEFARIAHH 488

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 87299630   518 YQLVFCYTIMERNSRqmlpviRSTAGGDSVQTcTNPLDTFFPFDPCVLKRSKKFIDPIYQIWED 581
Cdd:pfam05327 489 LQFAYCFSIIESNKR------EETAGTATGQE-FEQLDAYFPFDPYLLPRSKRWIEPDYVEWSE 545
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH