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Conserved domains on  [gi|115532350|ref|NP_001040690|]
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Anticodon-binding domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HGTP_anticodon super family cl00266
HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and ...
 1-85 1.30e-15

HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for specificity in tRNA-binding, so that the activated amino acid is transferred to a ribose 3' OH group of the appropriate tRNA only. This domain is also found in the accessory subunit of mitochondrial polymerase gamma (Pol gamma b).


The actual alignment was detected with superfamily member cd00861:

Pssm-ID: 469699 [Multi-domain]  Cd Length: 94  Bit Score: 66.46  E-value: 1.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532350   1 MASSSASRYLKGGI--LLDDRVEmSAGKRIHDANRLGIPFILVIANETErslatQKPVIEVFTTHAKSAEPMSQgsmslD 78
Cdd:cd00861   19 LAEKLYAELQAAGVdvLLDDRNE-RPGVKFADADLIGIPYRIVVGKKSA-----AEGIVEIKVRKTGEKEEISI-----D 87


                 ....*..
gi 115532350  79 RFVTFVQ 85
Cdd:cd00861   88 ELLEFLQ 94
 
Name Accession Description Interval E-value
ProRS_anticodon_short cd00861
ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS ...
 1-85 1.30e-15

ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is transferred to a ribose 3' OH group of the appropriate tRNA only.


Pssm-ID: 238438 [Multi-domain]  Cd Length: 94  Bit Score: 66.46  E-value: 1.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532350   1 MASSSASRYLKGGI--LLDDRVEmSAGKRIHDANRLGIPFILVIANETErslatQKPVIEVFTTHAKSAEPMSQgsmslD 78
Cdd:cd00861   19 LAEKLYAELQAAGVdvLLDDRNE-RPGVKFADADLIGIPYRIVVGKKSA-----AEGIVEIKVRKTGEKEEISI-----D 87


                 ....*..
gi 115532350  79 RFVTFVQ 85
Cdd:cd00861   88 ELLEFLQ 94
HGTP_anticodon pfam03129
Anticodon binding domain; This domain is found in histidyl, glycyl, threonyl and prolyl tRNA ...
 2-86 4.68e-10

Anticodon binding domain; This domain is found in histidyl, glycyl, threonyl and prolyl tRNA synthetases it is probably the anticodon binding domain.


Pssm-ID: 460819 [Multi-domain]  Cd Length: 94  Bit Score: 52.20  E-value: 4.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532350    2 ASSSASRYLKGGI--LLDDRvEMSAGKRIHDANRLGIPFILVIaneTERSLATQKPVIEVFTThaksaepMSQGSMSLDR 79
Cdd:pfam03129  18 AQKLAEELRAAGIrvELDDR-NESIGKKFRRADLIGIPFALVV---GEKELEEGTVTVRRRDT-------GEQETVSLDE 86


                  ....*..
gi 115532350   80 FVTFVQS 86
Cdd:pfam03129  87 LVEKLKE 93
PRK03991 PRK03991
threonyl-tRNA synthetase; Validated
 16-42 7.88e-03

threonyl-tRNA synthetase; Validated


Pssm-ID: 235190 [Multi-domain]  Cd Length: 613  Bit Score: 34.46  E-value: 7.88e-03
                         10        20
                 ....*....|....*....|....*..
gi 115532350  16 LDDRVEmSAGKRIHDANRLGIPFILVI 42
Cdd:PRK03991 531 VDDRDE-SLGKKIRDAGKEWIPYVVVI 556
 
Name Accession Description Interval E-value
ProRS_anticodon_short cd00861
ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS ...
 1-85 1.30e-15

ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is transferred to a ribose 3' OH group of the appropriate tRNA only.


Pssm-ID: 238438 [Multi-domain]  Cd Length: 94  Bit Score: 66.46  E-value: 1.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532350   1 MASSSASRYLKGGI--LLDDRVEmSAGKRIHDANRLGIPFILVIANETErslatQKPVIEVFTTHAKSAEPMSQgsmslD 78
Cdd:cd00861   19 LAEKLYAELQAAGVdvLLDDRNE-RPGVKFADADLIGIPYRIVVGKKSA-----AEGIVEIKVRKTGEKEEISI-----D 87


                 ....*..
gi 115532350  79 RFVTFVQ 85
Cdd:cd00861   88 ELLEFLQ 94
HGTP_anticodon pfam03129
Anticodon binding domain; This domain is found in histidyl, glycyl, threonyl and prolyl tRNA ...
 2-86 4.68e-10

Anticodon binding domain; This domain is found in histidyl, glycyl, threonyl and prolyl tRNA synthetases it is probably the anticodon binding domain.


Pssm-ID: 460819 [Multi-domain]  Cd Length: 94  Bit Score: 52.20  E-value: 4.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115532350    2 ASSSASRYLKGGI--LLDDRvEMSAGKRIHDANRLGIPFILVIaneTERSLATQKPVIEVFTThaksaepMSQGSMSLDR 79
Cdd:pfam03129  18 AQKLAEELRAAGIrvELDDR-NESIGKKFRRADLIGIPFALVV---GEKELEEGTVTVRRRDT-------GEQETVSLDE 86


                  ....*..
gi 115532350   80 FVTFVQS 86
Cdd:pfam03129  87 LVEKLKE 93
PRK03991 PRK03991
threonyl-tRNA synthetase; Validated
 16-42 7.88e-03

threonyl-tRNA synthetase; Validated


Pssm-ID: 235190 [Multi-domain]  Cd Length: 613  Bit Score: 34.46  E-value: 7.88e-03
                         10        20
                 ....*....|....*....|....*..
gi 115532350  16 LDDRVEmSAGKRIHDANRLGIPFILVI 42
Cdd:PRK03991 531 VDDRDE-SLGKKIRDAGKEWIPYVVVI 556
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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