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Conserved domains on  [gi|115533142|ref|NP_001041093|]
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Fork-head domain-containing protein [Caenorhabditis elegans]

Protein Classification

forkhead box transcription factor( domain architecture ID 10646668)

forkhead box transcription factor contains a forkhead/winged helix DNA-binding domain and is involved in regulating diverse biological processes

Gene Ontology:  GO:0006355

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FH smart00339
FORKHEAD; FORKHEAD, also known as a "winged helix"
 125-217 2.61e-21

FORKHEAD; FORKHEAD, also known as a "winged helix"


:

Pssm-ID: 214627 [Multi-domain]  Cd Length: 89  Bit Score: 86.91  E-value: 2.61e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533142   125 SMVCWLFRTLLTSEYRALPANAIFEIFEETMQQSTAGSaRHYRDSIRHCLMTSAVFVRVLTpnpRKDFLVMneqGSWWTV 204
Cdd:smart00339   5 SYIALIAMAILSSPDKRLTLSEIYKWIEDNFPYYRENR-AGWQNSIRHNLSLNDCFVKVPR---EGDRPGK---GSYWTL 77

                           90
                   ....*....|...
gi 115533142   205 HPDCEMaCAEHVF 217
Cdd:smart00339  78 DPAAEN-MFENGN 89
 
Name Accession Description Interval E-value
FH smart00339
FORKHEAD; FORKHEAD, also known as a "winged helix"
 125-217 2.61e-21

FORKHEAD; FORKHEAD, also known as a "winged helix"


Pssm-ID: 214627 [Multi-domain]  Cd Length: 89  Bit Score: 86.91  E-value: 2.61e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533142   125 SMVCWLFRTLLTSEYRALPANAIFEIFEETMQQSTAGSaRHYRDSIRHCLMTSAVFVRVLTpnpRKDFLVMneqGSWWTV 204
Cdd:smart00339   5 SYIALIAMAILSSPDKRLTLSEIYKWIEDNFPYYRENR-AGWQNSIRHNLSLNDCFVKVPR---EGDRPGK---GSYWTL 77

                           90
                   ....*....|...
gi 115533142   205 HPDCEMaCAEHVF 217
Cdd:smart00339  78 DPAAEN-MFENGN 89
Forkhead pfam00250
Forkhead domain;
169-209 7.26e-05

Forkhead domain;


Pssm-ID: 459732  Cd Length: 86  Bit Score: 40.92  E-value: 7.26e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 115533142  169 SIRHCLMTSAVFVRV--LTPNPRKdflvmneqGSWWTVHPDCE 209
Cdd:pfam00250  48 SIRHNLSLNKCFVKVprPKDEPGK--------GSYWTIDPEYE 82
FH_FOXQ2-like cd20035
Forkhead (FH) domain found in Forkhead box protein Q2 (FOXQ2) and similar proteins; FOXQ2 is ...
 166-224 2.38e-04

Forkhead (FH) domain found in Forkhead box protein Q2 (FOXQ2) and similar proteins; FOXQ2 is the neurogenic ectoderm specification transcription factor that controls aboral development in cnidarians and anterior identity in bilaterians. It plays essential roles in epidermal development and central brain patterning. The foxQ2 gene is absent in placental mammals. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410809 [Multi-domain]  Cd Length: 95  Bit Score: 39.53  E-value: 2.38e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 115533142 166 YRDSIRHCLMTSAVFVRVltpnPRKDflvmNEQGSWWTVHPDCEMACAEHVFRSGSAHR 224
Cdd:cd20035   45 WKNSVRHNLSLNECFVKA----GRAE----NGKGNYWTIHPACLEDFEKGDFRRRRARR 95
 
Name Accession Description Interval E-value
FH smart00339
FORKHEAD; FORKHEAD, also known as a "winged helix"
 125-217 2.61e-21

FORKHEAD; FORKHEAD, also known as a "winged helix"


Pssm-ID: 214627 [Multi-domain]  Cd Length: 89  Bit Score: 86.91  E-value: 2.61e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115533142   125 SMVCWLFRTLLTSEYRALPANAIFEIFEETMQQSTAGSaRHYRDSIRHCLMTSAVFVRVLTpnpRKDFLVMneqGSWWTV 204
Cdd:smart00339   5 SYIALIAMAILSSPDKRLTLSEIYKWIEDNFPYYRENR-AGWQNSIRHNLSLNDCFVKVPR---EGDRPGK---GSYWTL 77

                           90
                   ....*....|...
gi 115533142   205 HPDCEMaCAEHVF 217
Cdd:smart00339  78 DPAAEN-MFENGN 89
Forkhead pfam00250
Forkhead domain;
169-209 7.26e-05

Forkhead domain;


Pssm-ID: 459732  Cd Length: 86  Bit Score: 40.92  E-value: 7.26e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 115533142  169 SIRHCLMTSAVFVRV--LTPNPRKdflvmneqGSWWTVHPDCE 209
Cdd:pfam00250  48 SIRHNLSLNKCFVKVprPKDEPGK--------GSYWTIDPEYE 82
FH_FOXQ2-like cd20035
Forkhead (FH) domain found in Forkhead box protein Q2 (FOXQ2) and similar proteins; FOXQ2 is ...
 166-224 2.38e-04

Forkhead (FH) domain found in Forkhead box protein Q2 (FOXQ2) and similar proteins; FOXQ2 is the neurogenic ectoderm specification transcription factor that controls aboral development in cnidarians and anterior identity in bilaterians. It plays essential roles in epidermal development and central brain patterning. The foxQ2 gene is absent in placental mammals. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410809 [Multi-domain]  Cd Length: 95  Bit Score: 39.53  E-value: 2.38e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 115533142 166 YRDSIRHCLMTSAVFVRVltpnPRKDflvmNEQGSWWTVHPDCEMACAEHVFRSGSAHR 224
Cdd:cd20035   45 WKNSVRHNLSLNECFVKA----GRAE----NGKGNYWTIHPACLEDFEKGDFRRRRARR 95
FH_FOXH cd20022
Forkhead (FH) domain found in the Forkhead box protein H (FOXH) subfamily; The FOXH subfamily ...
 161-204 9.49e-03

Forkhead (FH) domain found in the Forkhead box protein H (FOXH) subfamily; The FOXH subfamily includes a winged helix transcription factor, FOXH1, which is also called Forkhead activin signal transducer 1 (Fast-1), or Forkhead activin signal transducer 2 (Fast-2). FOXH1 acts as a transcriptional activator that recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. It is required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. FOXH1 forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element). The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410796 [Multi-domain]  Cd Length: 79  Bit Score: 34.65  E-value: 9.49e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 115533142 161 GSARHYRDSIRHCLMTSAVFVRVLtpnprKDFLVMNEQGSWWTV 204
Cdd:cd20022   40 GEYKGWKDSVRHNLSSNDCFVKVL-----KDPGKPQAKGNYWTV 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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