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Conserved domains on  [gi|124486722|ref|NP_001074540|]
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lysocardiolipin acyltransferase 1 [Mus musculus]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10870651)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0016746|GO:0008654|GO:0006644
PubMed:  18287005|18931347|18718904|37611890
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 55-248 2.82e-87

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


:

Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 261.79  E-value: 2.82e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722  55 VALLETMFGVRVVITGDAF-VPGERSVIIMNHRTRVDWMFLWNCLMRYSYLRVEKICLKSSLKSVPGFGWAMQVAAFIFI 133
Cdd:cd07990    1 VFLFEWLSGVKVVVYGDEPkLPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722 134 HRKWKDDKSHFEDMIDYFCAIHEPLQLLIFPEGTDLTENNKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVDRLREGknL 213
Cdd:cd07990   81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDA--V 158

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 124486722 214 DAVHDITVAYPYNIPQTEKHLLLGDFPKEIHFHVQ 248
Cdd:cd07990  159 DAVYDVTIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 233-307 8.45e-16

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


:

Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 71.45  E-value: 8.45e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124486722  233 HLLLGdFPKEIHFHVQRYPADSLPTSKEDLQLWCHRRWEEKEERLRSFYQgEKNFHFTGQSTVPPCKSELRVLVV 307
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYE-TGTFFPGKEHIIPRRLKSLLVFIF 73
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 55-248 2.82e-87

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 261.79  E-value: 2.82e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722  55 VALLETMFGVRVVITGDAF-VPGERSVIIMNHRTRVDWMFLWNCLMRYSYLRVEKICLKSSLKSVPGFGWAMQVAAFIFI 133
Cdd:cd07990    1 VFLFEWLSGVKVVVYGDEPkLPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722 134 HRKWKDDKSHFEDMIDYFCAIHEPLQLLIFPEGTDLTENNKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVDRLREGknL 213
Cdd:cd07990   81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDA--V 158

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 124486722 214 DAVHDITVAYPYNIPQTEKHLLLGDFPKEIHFHVQ 248
Cdd:cd07990  159 DAVYDVTIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 5-327 1.78e-61

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 201.85  E-value: 1.78e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722   5 KGIYFILFLFAGSFFGSIFmLGPILPLM--FINLSWYRWISSRLVATWLTLPVALLETMFGVRVVITGDAFVPGERSVII 82
Cdd:PLN02510  19 RGLICLLVLLSTAFMMLVY-LAPVSAVLlrLFSVHYSRKATSFFFGSWLALWPFLFEKINKTKVVFSGDKVPPEERVLLI 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722  83 MNHRTRVDWMFLWNCLMRYSYLRVEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKDDKSHFEDMIDYFCAIHEPLQLLI 162
Cdd:PLN02510  98 ANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFIPVERKWEVDEPNIRQMLSSFKDPRDPLWLAL 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722 163 FPEGTDLTENNKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVDRLREgkNLDAVHDITVAYPYNIPqTEKHLLLGDFPKE 242
Cdd:PLN02510 178 FPEGTDYTEAKCQRSQKFAAEHGLPILNNVLLPKTKGFVSCLQELRC--SLDAVYDVTIGYKHRCP-SFLDNVFGIDPSE 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722 243 IHFHVQRYPADSLPTSKEDLQLWCHRRWEEKEERLRSFYqgeKNFHFTGQST-----VPPCKSELrVLVVKLLSIVYWAL 317
Cdd:PLN02510 255 VHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFY---AQGHFPNEGTegelsTLKCLANF-LAVIALTTVFTYLT 330

                        330
                 ....*....|
gi 124486722 318 FCSAMCLLIY 327
Cdd:PLN02510 331 LFSSVWFKIY 340
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 80-171 1.97e-16

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 74.70  E-value: 1.97e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722    80 VIIMNHRTRVDWMFLWNCLmrYSYLRVEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKDDKSHFedMIDYFCAIHEPLQ 159
Cdd:smart00563   2 LVVANHQSFLDPLVLSALL--PRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAA--LREAVELLKEGEW 77

                           90
                   ....*....|..
gi 124486722   160 LLIFPEGTDLTE 171
Cdd:smart00563  78 LLIFPEGTRSRP 89
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 233-307 8.45e-16

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 71.45  E-value: 8.45e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124486722  233 HLLLGdFPKEIHFHVQRYPADSLPTSKEDLQLWCHRRWEEKEERLRSFYQgEKNFHFTGQSTVPPCKSELRVLVV 307
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYE-TGTFFPGKEHIIPRRLKSLLVFIF 73
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 65-223 2.10e-14

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 69.23  E-value: 2.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722   65 RVVITGDAFVP-GERSVIIMNHRTRVDWMFLWNCLmrYSYLRVEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKDDKSH 143
Cdd:pfam01553   1 RIEVHGLENLPrGGPAIVVANHQSYLDVLLLSLAL--YKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722  144 FEDMIDYfcAIHEPLQLLIFPEGTdltennkaRSNdfaeknglqkyEYVLHPRTTGFTFVVDRLRegknldaVHDITVAY 223
Cdd:pfam01553  79 TLEYLVE--LLREGKLVVIFPEGT--------RSR-----------EGELLPFKKGAFRLAIEAG-------VPIVPVAI 130
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 36-167 1.09e-13

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 69.65  E-value: 1.09e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722  36 LSWYRWISSRLVATWLTLPVALLETMFGVRVVITGDAFVPGERSVIIM-NHRTRVDWMFLWNCLMRY-SYLrvekicLKS 113
Cdd:COG0204    1 LRSLFLLLRRFRYRLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVaNHQSWLDILLLLAALPRPvRFV------AKK 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 124486722 114 SLKSVPGFGWAMQVAAFIFIHR-KWKDDKSHFEDMIDyfcAIHEPLQLLIFPEGT 167
Cdd:COG0204   75 ELFKIPLLGWLLRALGAIPVDRsKRRAALRALRQAVE---ALKAGESLVIFPEGT 126
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 63-167 1.70e-06

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 46.96  E-value: 1.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722   63 GVRVVITGDAFVPGERSVIIM-NHRTRVDwMFLWNCLMRYSYLRVEKIclksSLKSVPGFGWAMQVAAFIFIHRK-WKDD 140
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVaNHQSNLD-PLTLSAAFPPPIVFIAKK----ELKWIPFFGIMLWLTGAIFIDREnIRAI 75

                          90       100
                  ....*....|....*....|....*..
gi 124486722  141 KSHFEDMIDyfcAIHEPLQLLIFPEGT 167
Cdd:TIGR00530  76 ATALKAAIE---VLKQGRSIGVFPEGT 99
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 55-248 2.82e-87

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 261.79  E-value: 2.82e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722  55 VALLETMFGVRVVITGDAF-VPGERSVIIMNHRTRVDWMFLWNCLMRYSYLRVEKICLKSSLKSVPGFGWAMQVAAFIFI 133
Cdd:cd07990    1 VFLFEWLSGVKVVVYGDEPkLPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722 134 HRKWKDDKSHFEDMIDYFCAIHEPLQLLIFPEGTDLTENNKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVDRLREGknL 213
Cdd:cd07990   81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDA--V 158

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 124486722 214 DAVHDITVAYPYNIPQTEKHLLLGDFPKEIHFHVQ 248
Cdd:cd07990  159 DAVYDVTIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 5-327 1.78e-61

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 201.85  E-value: 1.78e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722   5 KGIYFILFLFAGSFFGSIFmLGPILPLM--FINLSWYRWISSRLVATWLTLPVALLETMFGVRVVITGDAFVPGERSVII 82
Cdd:PLN02510  19 RGLICLLVLLSTAFMMLVY-LAPVSAVLlrLFSVHYSRKATSFFFGSWLALWPFLFEKINKTKVVFSGDKVPPEERVLLI 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722  83 MNHRTRVDWMFLWNCLMRYSYLRVEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKDDKSHFEDMIDYFCAIHEPLQLLI 162
Cdd:PLN02510  98 ANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFIPVERKWEVDEPNIRQMLSSFKDPRDPLWLAL 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722 163 FPEGTDLTENNKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVDRLREgkNLDAVHDITVAYPYNIPqTEKHLLLGDFPKE 242
Cdd:PLN02510 178 FPEGTDYTEAKCQRSQKFAAEHGLPILNNVLLPKTKGFVSCLQELRC--SLDAVYDVTIGYKHRCP-SFLDNVFGIDPSE 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722 243 IHFHVQRYPADSLPTSKEDLQLWCHRRWEEKEERLRSFYqgeKNFHFTGQST-----VPPCKSELrVLVVKLLSIVYWAL 317
Cdd:PLN02510 255 VHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFY---AQGHFPNEGTegelsTLKCLANF-LAVIALTTVFTYLT 330

                        330
                 ....*....|
gi 124486722 318 FCSAMCLLIY 327
Cdd:PLN02510 331 LFSSVWFKIY 340
PLN02380 PLN02380
1-acyl-sn-glycerol-3-phosphate acyltransferase
 10-344 2.51e-33

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178006 [Multi-domain]  Cd Length: 376  Bit Score: 127.55  E-value: 2.51e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722  10 ILFLFAGSFFGSI----FMLgpILPLmfiNLSWYRWISSRLV-ATWLTLpVALLETMFGVRVVITGDA----FVPGERSV 80
Cdd:PLN02380  14 LLFLLSGLIVNLIqavcFIL--VRPL---SKSLYRRINRAVAeLLWLEL-IWLVDWWAGVKVQLYADEetfeLMGKEHAL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722  81 IIMNHRTRVDWMFLWNCLMRYSYLRVEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKDD----KSHFEDMIDYfcaiHE 156
Cdd:PLN02380  88 VISNHRSDIDWLVGWILAQRSGCLGSALAVMKKSSKFLPVIGWSMWFSEYVFLERSWAKDentlKSGFQRLKDF----PR 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722 157 PLQLLIFPEGTDLTENNKARSNDFAEKNGLQKYEYVLHPRTTGFTFVVDRLREgkNLDAVHDITVAYPYNIPQTEKHLLL 236
Cdd:PLN02380 164 PFWLALFVEGTRFTQAKLLAAQEYAASRGLPVPRNVLIPRTKGFVSAVSNMRS--FVPAIYDVTVAVPKGQPAPTMLRIF 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722 237 GDFPKEIHFHVQRYPADSLPTSKEDLQLWCHRRWEEKEERLRSFyqgEKNFHFTGQSTVP---PCKSelrvlvvkLLSIV 313
Cdd:PLN02380 242 RGQSSVVHVHIKRHSMKELPETDDGIAQWCKDVFVAKDALLDKH---FAEDTFGDQEYQDigrPKKS--------LIVVI 310

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 124486722 314 YWAlfcsamCLLIY-LYSPVRWYFIIS----IVFFV 344
Cdd:PLN02380 311 SWA------CLLILgAIKFLQWLSLLSswkgIASLA 340
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 80-171 1.97e-16

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 74.70  E-value: 1.97e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722    80 VIIMNHRTRVDWMFLWNCLmrYSYLRVEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKDDKSHFedMIDYFCAIHEPLQ 159
Cdd:smart00563   2 LVVANHQSFLDPLVLSALL--PRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAA--LREAVELLKEGEW 77

                           90
                   ....*....|..
gi 124486722   160 LLIFPEGTDLTE 171
Cdd:smart00563  78 LLIFPEGTRSRP 89
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 233-307 8.45e-16

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 71.45  E-value: 8.45e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124486722  233 HLLLGdFPKEIHFHVQRYPADSLPTSKEDLQLWCHRRWEEKEERLRSFYQgEKNFHFTGQSTVPPCKSELRVLVV 307
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYE-TGTFFPGKEHIIPRRLKSLLVFIF 73
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 63-248 7.13e-15

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 72.06  E-value: 7.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722  63 GVRVVITGDAFVPGERSVIIM-NHRTRVDWMFLWnCLMRYSYLRVEKICLK-SSLKSVPGFGWamqvAAFIFIHRKW-KD 139
Cdd:cd06551   11 FVRLEVKGPPPPPGGGPVLFVsNHSSWWDGLILF-LLLERGLRRDVYGLMDeELLERYPFFTR----LGAFSVDRDSpRS 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722 140 DKSHFEDMIDYFCAIHEplQLLIFPEGTDLTEnnkarsndfaEKNGLQKYEYVLHP-RTTGFTFVVDRLREGKNL-DAVH 217
Cdd:cd06551   86 AAKSLKYVARLLSKPGS--VVWIFPEGTRTRR----------DKRPLQFKPGVAHLaEKAGVPIVPVALRYTFELfEQFP 153

                        170       180       190
                 ....*....|....*....|....*....|....
gi 124486722 218 DITVAYPYNIPQTEKH---LLLGDFPKEIHFHVQ 248
Cdd:cd06551  154 EIFVRIGPPIPYAETAlgeELAAELANRLTRLLD 187
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 65-223 2.10e-14

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 69.23  E-value: 2.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722   65 RVVITGDAFVP-GERSVIIMNHRTRVDWMFLWNCLmrYSYLRVEKICLKSSLKSVPGFGWAMQVAAFIFIHRKWKDDKSH 143
Cdd:pfam01553   1 RIEVHGLENLPrGGPAIVVANHQSYLDVLLLSLAL--YKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722  144 FEDMIDYfcAIHEPLQLLIFPEGTdltennkaRSNdfaeknglqkyEYVLHPRTTGFTFVVDRLRegknldaVHDITVAY 223
Cdd:pfam01553  79 TLEYLVE--LLREGKLVVIFPEGT--------RSR-----------EGELLPFKKGAFRLAIEAG-------VPIVPVAI 130
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 36-167 1.09e-13

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 69.65  E-value: 1.09e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722  36 LSWYRWISSRLVATWLTLPVALLETMFGVRVVITGDAFVPGERSVIIM-NHRTRVDWMFLWNCLMRY-SYLrvekicLKS 113
Cdd:COG0204    1 LRSLFLLLRRFRYRLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVaNHQSWLDILLLLAALPRPvRFV------AKK 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 124486722 114 SLKSVPGFGWAMQVAAFIFIHR-KWKDDKSHFEDMIDyfcAIHEPLQLLIFPEGT 167
Cdd:COG0204   75 ELFKIPLLGWLLRALGAIPVDRsKRRAALRALRQAVE---ALKAGESLVIFPEGT 126
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 61-167 1.25e-11

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 62.67  E-value: 1.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722  61 MFGVRVVITGDAFVPGERSVIIM-NHRTRVDWMFLWNCLMRY-SYLrvekicLKSSLKSVPGFGWAMQVAAFIFIHR-KW 137
Cdd:cd07989    7 LLGVRVRVEGLENLPPKGPVIIVaNHQSYLDPLVLGAALPRPiRFV------AKKELFKIPFLGWLLRLLGAIPIDRgNG 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 124486722 138 KDDKSHFEDMIDyfcAIHEPLQLLIFPEGT 167
Cdd:cd07989   81 RSAREALREAIE---ALKEGESVVIFPEGT 107
PRK14014 PRK14014
putative acyltransferase; Provisional
 8-286 2.67e-09

putative acyltransferase; Provisional


Pssm-ID: 237584 [Multi-domain]  Cd Length: 301  Bit Score: 57.55  E-value: 2.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722   8 YFILFLFAGSFFG--SIFMLGPILPLMFINL----SWYRWISSRLV----ATWLTLPVALLETMFGVRVVITGDA-FVPG 76
Cdd:PRK14014   7 APLRGLLSILLLIlnTLFWSVPIIILGLLKLllpiPAIRRACSRLLnfiaEAWISINNVILRLLPRTQWDVEGLEgLSKK 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722  77 ERSVIIMNHRTRVDWMFLwnclMRYSYLRVE--KICLKSSLKSVP--GFG-WAMQvaaFIFIHR------------KWKD 139
Cdd:PRK14014  87 GWYLVISNHQSWVDILVL----QYVFNRRIPmlKFFLKQELIWVPflGLAwWALD---FPFMKRyskaylaknpelKGKD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722 140 ----DKShfedmidyfCAI--HEPLQLLIFPEGTDLTENNKARSNdfaeknglQKYEYVLHPRTTGFTFVVDRLreGKNL 213
Cdd:PRK14014 160 lettRRA---------CEKfkRMPTTIVNFVEGTRFTPEKHQQQQ--------SPYQHLLKPKAGGIAFALNAM--GEQF 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722 214 DAVHDITVAYPYNIPqTEKHLLLGDfPKEIHFHVQRYPADSL--------PTSKEDLQLWCHRRWEEKEERLRSFYQGEK 285
Cdd:PRK14014 221 DGLLDVTIVYPDGRP-SFWDLLSGR-VKKIVVHVRLLPIPEEligdyfndKEFRRRFQQWLNQLWQEKDQLIEQLLAQYN 298


                 .
gi 124486722 286 N 286
Cdd:PRK14014 299 Q 299
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 63-167 1.70e-06

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 46.96  E-value: 1.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722   63 GVRVVITGDAFVPGERSVIIM-NHRTRVDwMFLWNCLMRYSYLRVEKIclksSLKSVPGFGWAMQVAAFIFIHRK-WKDD 140
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVaNHQSNLD-PLTLSAAFPPPIVFIAKK----ELKWIPFFGIMLWLTGAIFIDREnIRAI 75

                          90       100
                  ....*....|....*....|....*..
gi 124486722  141 KSHFEDMIDyfcAIHEPLQLLIFPEGT 167
Cdd:TIGR00530  76 ATALKAAIE---VLKQGRSIGVFPEGT 99
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 80-175 4.51e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 41.05  E-value: 4.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124486722  80 VIIMNHRTRVDWMFLWNCLMrYSYLRvekiclKSSLKSVPGFGWAMQVAAFIFIHRKWKDDKSHFEDMIDYFCAIHEPLQ 159
Cdd:cd07991   27 IIVANHTSFIDPLILFSDLF-PSIVA------KKELGKLPFIGTILRALGCIFVDRSEPKDRKKVVEEIKERATDPNWPP 99

                         90
                 ....*....|....*.
gi 124486722 160 LLIFPEGTdlTENNKA 175
Cdd:cd07991  100 ILIFPEGT--TTNGKA 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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