|
Name |
Accession |
Description |
Interval |
E-value |
| CCDC144C |
pfam14915 |
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ... |
886-1189 |
6.06e-153 |
|
CCDC144C protein coiled-coil region; This family includes the human protein CCDC144C and the ankyrin repeat domain-containing protein 26-like 1 found in eukaryotes. Its function remains unknown, however, it is known to contain a coiled-coil domain which corresponds to this region. The ankyrin repeat which features in this protein is a common amino acid motif.
Pssm-ID: 464371 [Multi-domain] Cd Length: 304 Bit Score: 469.47 E-value: 6.06e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 886 NQRLQDEVAVLRLEMDTIKSHNQEKEKRYLEDIKIANEKNDNLQRMVKLNEETFTKTIFQYTGQLNSLKAENTMLSSKLD 965
Cdd:pfam14915 1 NCMLQDEIAMLRLEIDTIKNQNQEKEKKYLEDIEILKEKNDDLQKTLKLNEETLTKTVFQYNGQLNVLKAENTMLNSKLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 966 NEKQNKERLETDVESFRSRLASALHDHAEIQTAKRDLEIAFQRARDEWFRVKDKMNFDMSNLRDNNEVLSQQLSKTERKL 1045
Cdd:pfam14915 81 NEKQNKERLETEVESYRSRLAAAIQDHEQSQTSKRDLELAFQRERDEWLRLQDKMNFDVSNLRDENEILSQQLSKAESKA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1046 NSLEIEFHHTKDELREKTLALKHAQRDLSQTQCQMKEVEHMFQDEQGKVSKFMGKQESIEERLAQLQSENTLLRQQLDDA 1125
Cdd:pfam14915 161 NSLENELHRTRDALREKTLLLESVQRDLSQAQCQKKELEHMYQNEQDKVNKYIGKQESLEERLAQLQSENMLLRQQLEDA 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124487433 1126 ANKAESKDKTIVNIQDQFQDVLTRFQAESQRHSLRLEDRNQELVSECSHLRERLCQYENEKAER 1189
Cdd:pfam14915 241 QNKADAKEKTVIDIQDQFQDIVKKLQAESEKQVLLLEERNKELINECNHLKERLYQYEKEKAER 304
|
|
| DUF3496 |
pfam12001 |
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. ... |
1495-1602 |
1.35e-51 |
|
Domain of unknown function (DUF3496); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 110 amino acids in length.
Pssm-ID: 463425 [Multi-domain] Cd Length: 109 Bit Score: 177.16 E-value: 1.35e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1495 RSQMELRIKDLESQLYRMKA-QEDFDKIELEKYKQLYQEEFRARKSLSSKLNKTSEKLEEASSKLLLEEQQNRSLLSTLS 1573
Cdd:pfam12001 1 RSQMELRIKDLESELSKMKTsQEDSNKIELEKYKQLYLEELKVRKSLSNKLNKTNERLAEVSTKLLVEKQQNRSLLSTLT 80
|
90 100
....*....|....*....|....*....
gi 124487433 1574 TRPVVECPCVGSFHNSLVFNRTLIPRENI 1602
Cdd:pfam12001 81 TRPVLESPCVGNLNNSLVLNRNFIPRENL 109
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
51-219 |
1.92e-40 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 152.03 E-value: 1.92e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 51 IHKAASVGDVAKVQHILILGKSgVNDRDKKDRTALHLACAYGHPEVVTLLVERKCEIDARDSESSTALIKAVQCQEEECA 130
Cdd:COG0666 91 LHAAARNGDLEIVKLLLEAGAD-VNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIV 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 131 AILLDHGADPNVMDSSGNTALHYAVYSENTSMAAKLLAHNANIEAKNKDDLTPMLLAVKENKQHIVEFLVKKKASIHAVD 210
Cdd:COG0666 170 KLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKD 249
|
....*....
gi 124487433 211 QLGSNRQMF 219
Cdd:COG0666 250 KDGLTALLL 258
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
42-213 |
7.29e-40 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 150.10 E-value: 7.29e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 42 HIHDKDMGKIHKAASVGDVAKVQHILILGKSGVNDRDKKDRTALHLACAYGHPEVVTLLVERKCEIDARDSESSTALIKA 121
Cdd:COG0666 48 ALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLA 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 122 VQCQEEECAAILLDHGADPNVMDSSGNTALHYAVYSENTSMAAKLLAHNANIEAKNKDDLTPMLLAVKENKQHIVEFLVK 201
Cdd:COG0666 128 AYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLE 207
|
170
....*....|..
gi 124487433 202 KKASIHAVDQLG 213
Cdd:COG0666 208 AGADVNAKDNDG 219
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
51-215 |
9.96e-33 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 129.69 E-value: 9.96e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 51 IHKAASVGDVAKVQHILILGKSgVNDRDKKDRTALHLACAYGHPEVVTLLVERKCEIDARDSESSTALIKAVQCQEEECA 130
Cdd:COG0666 124 LHLAAYNGNLEIVKLLLEAGAD-VNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIV 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 131 AILLDHGADPNVMDSSGNTALHYAVYSENTSMAAKLLAHNANIEAKNKDDLTPMLLAVKENKQHIVEFLVKKKASIHAVD 210
Cdd:COG0666 203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282
|
....*
gi 124487433 211 QLGSN 215
Cdd:COG0666 283 LDLLT 287
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
43-213 |
5.16e-30 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 121.60 E-value: 5.16e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 43 IHDKDMGKIHKAASVGDVAKVQHILILGKSGVNDRDKKDRTALHLACAYGHPEVVTLLVERKCEIDARDSESSTALIKAV 122
Cdd:COG0666 16 LLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 123 QCQEEECAAILLDHGADPNVMDSSGNTALHYAVYSENTSMAAKLLAHNANIEAKNKDDLTPMLLAVKENKQHIVEFLVKK 202
Cdd:COG0666 96 RNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA 175
|
170
....*....|.
gi 124487433 203 KASIHAVDQLG 213
Cdd:COG0666 176 GADVNARDNDG 186
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
712-1559 |
1.04e-23 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 109.38 E-value: 1.04e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 712 ELKRSHCELLTGKLKRMENKYKGLQKEMSETEEVKSRLEHEKVGWEQELCRLRFALKQEEEKRRSADQLSEKTSEQLRRK 791
Cdd:TIGR02168 221 ELRELELALLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRL 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 792 GEQCQSEVEARQQLEASLRTLEMELKTVKSHLNQVLEERNETQRQLSREQNarmlqdgilashLCKQKEIEMTQKKMTSE 871
Cdd:TIGR02168 301 EQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKE------------ELESLEAELEELEAELE 368
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 872 VSVSHEKEKDLLHknQRLQDEVAVLRLEMDTIKSHNQEKEKRyledIKIANEKNDNLQRMVKLNEETFTKTIFQYT-GQL 950
Cdd:TIGR02168 369 ELESRLEELEEQL--ETLRSKVAQLELQIASLNNEIERLEAR----LERLEDRRERLQQEIEELLKKLEEAELKELqAEL 442
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 951 NSLKAENTMLSSKLDNEKQNKERLETDVESFRSRLASALHDHAEIQTAKRDLEIAFQRARDEWFRVKDKMN--FDMSNLR 1028
Cdd:TIGR02168 443 EELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKnqSGLSGIL 522
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1029 DnneVLSQQLSKTERKLNSLEIefhhtkdelrektlAL-KHAQRDLSQT-QCQMKEVEHMFQDEQGKVSKFMGKQesieE 1106
Cdd:TIGR02168 523 G---VLSELISVDEGYEAAIEA--------------ALgGRLQAVVVENlNAAKKAIAFLKQNELGRVTFLPLDS----I 581
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1107 RLAQLQSENTLLRQQLDDAANKAESKDKTIVNIQDQFQDVLTRF-------QAESQRHSLRLEDRnqeLVSECSHLRERL 1179
Cdd:TIGR02168 582 KGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVlvvddldNALELAKKLRPGYR---IVTLDGDLVRPG 658
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1180 CQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVSSRYRSNLEEEARDLKKKLGQLRSQLQEARDQHREAVHHAEKM 1259
Cdd:TIGR02168 659 GVITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARL 738
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1260 EDHLQKLELEKSKFEITIKKQSEEIDQLQENLsrvnlsEEDKEKLQKLTELKESLECTVDQEQKRSSALEKELAEFKEVL 1339
Cdd:TIGR02168 739 EAEVEQLEERIAQLSKELTELEAEIEELEERL------EEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAEL 812
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1340 KMTKKELNEYENRELNLRQDIknnhlemdipvSTLIKKIDDLTAKLETASskcLHLGKKNQLLQQELLLMRTIQKKCGKL 1419
Cdd:TIGR02168 813 TLLNEEAANLRERLESLERRI-----------AATERRLEDLEEQIEELS---EDIESLAAEIEELEELIEELESELEAL 878
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1420 EKNKKQLEQEVVNLRSHMEKNMVEHSQAQQYAREvEERARQDLVEKLKQVNLFLQ-AQAASQESLEQLRENSNASVRSQM 1498
Cdd:TIGR02168 879 LNERASLEEALALLRSELEELSEELRELESKRSE-LRRELEELREKLAQLELRLEgLEVRIDNLQERLSEEYSLTLEEAE 957
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124487433 1499 ELRIKDLESQlyrMKAQEDFDKIElEKYKQL------YQEEFRARKSLSSKLNKTSEKLEEASSKLL 1559
Cdd:TIGR02168 958 ALENKIEDDE---EEARRRLKRLE-NKIKELgpvnlaAIEEYEELKERYDFLTAQKEDLTEAKETLE 1020
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
85-177 |
9.07e-21 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 88.25 E-value: 9.07e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 85 LHLACAYGHPEVVTLLVERKCEIDARDSESSTALIKAVQCQEEECAAILLDHgADPNvMDSSGNTALHYAVYSENTSMAA 164
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVN-LKDNGRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 124487433 165 KLLAHNANIEAKN 177
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
708-1366 |
9.38e-20 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 96.66 E-value: 9.38e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 708 KRLIELKRShCELLTGKLKRMENKYKGLQKEMSETEEVKSRLEHEKVGWEQELCRLRFALKQEEEKRRSAD---QLSEKT 784
Cdd:TIGR02168 330 SKLDELAEE-LAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNneiERLEAR 408
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 785 SEQLRRKGEQCQSEVEA--RQQLEASLRTLEMELKTVKSHLNQVLEERNETQRQLSREQN----ARMLQDGILASHLCKQ 858
Cdd:TIGR02168 409 LERLEDRRERLQQEIEEllKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREeleeAEQALDAAERELAQLQ 488
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 859 KEIEMTQKkMTSEVSVSHEKEKDLLHKNQRLQDEV------------------AVLRLEMDTIKSHNQEKEKRylediKI 920
Cdd:TIGR02168 489 ARLDSLER-LQENLEGFSEGVKALLKNQSGLSGILgvlselisvdegyeaaieAALGGRLQAVVVENLNAAKK-----AI 562
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 921 ANEKNDNLQRMVKLNEETFTKTIFQYTGqLNSLKAENTMLSSKLDNEKQnKERLETDVESFRSR------LASALHDHAE 994
Cdd:TIGR02168 563 AFLKQNELGRVTFLPLDSIKGTEIQGND-REILKNIEGFLGVAKDLVKF-DPKLRKALSYLLGGvlvvddLDNALELAKK 640
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 995 IQTAKRDLEIAFQRARDEWFRVKDKMNFDMSNLRDNNEV--LSQQLSKTERKLNSLEIEFHHTKDELREKTLALKHAQRD 1072
Cdd:TIGR02168 641 LRPGYRIVTLDGDLVRPGGVITGGSAKTNSSILERRREIeeLEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKE 720
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1073 LSQTQCQMKEVEHMFQDEQGKVSKFMGKQESIEERLAQLQSENTLLRQQLDDAANKAESKDKTIVNIQDQFQDVLTRFQA 1152
Cdd:TIGR02168 721 LEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKA 800
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1153 ESQRHSlRLEDRNQELVSECSHLRERLCQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVSSRYRSNLEEEARDLK 1232
Cdd:TIGR02168 801 LREALD-ELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALL 879
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1233 KKLGQLRSQLQEARDQHREAVHHAEKMEDHLQKLE-------LEKSKFEITIKKQSEEIDQLQENLS-RVNLSEEDKEKL 1304
Cdd:TIGR02168 880 NERASLEEALALLRSELEELSEELRELESKRSELRreleelrEKLAQLELRLEGLEVRIDNLQERLSeEYSLTLEEAEAL 959
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124487433 1305 QKLTELKEslectvDQEQKRSSALEKELAEFKEVLKMTkkeLNEYEnrELNLRQDIKNNHLE 1366
Cdd:TIGR02168 960 ENKIEDDE------EEARRRLKRLENKIKELGPVNLAA---IEEYE--ELKERYDFLTAQKE 1010
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
51-184 |
2.91e-19 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 90.01 E-value: 2.91e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 51 IHKAASVGDVAKVQhILIlgKSG--VNDRDKKDRTALHLACAYGHPEVVTLLVERKCEIDARDSESSTALIKAVQCQEEE 128
Cdd:COG0666 157 LHLAAANGNLEIVK-LLL--EAGadVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLE 233
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 124487433 129 CAAILLDHGADPNVMDSSGNTALHYAVYSENTSMAAKLLAHNANIEAKNKDDLTPM 184
Cdd:COG0666 234 IVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
51-144 |
1.84e-18 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 81.70 E-value: 1.84e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 51 IHKAASVGDVAKVQHILILGkSGVNDRDKKDRTALHLACAYGHPEVVTLLVErKCEIDARDsESSTALIKAVQCQEEECA 130
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIV 77
|
90
....*....|....
gi 124487433 131 AILLDHGADPNVMD 144
Cdd:pfam12796 78 KLLLEKGADINVKD 91
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
66-213 |
1.83e-17 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 85.01 E-value: 1.83e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 66 ILILGKSGVNDRDKKDRTALHLACAYGHPEVVTLLVERKCEIDARDSESSTALIKAVQCQEEECAAILLDHGADPNVMDS 145
Cdd:COG0666 6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124487433 146 SGNTALHYAVYSENTSMAAKLLAHNANIEAKNKDDLTPMLLAVKENKQHIVEFLVKKKASIHAVDQLG 213
Cdd:COG0666 86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDG 153
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
695-1386 |
8.54e-17 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 87.03 E-value: 8.54e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 695 ASLLKIRDAVYSYKRLIELKRSHCELLTGKLKRMENKYKGLQKEMSETEEVKSRLEHEKVGWEQELCRLRFALKQEEEKR 774
Cdd:TIGR02168 267 EKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKL 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 775 RSADQLSEKTSEQLrrkgeqcQSEVEARQQLEASLRTLEMELKTVKSHLNQVLEERNETQRQLSR---------EQNARM 845
Cdd:TIGR02168 347 EELKEELESLEAEL-------EELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERlearlerleDRRERL 419
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 846 LQDGILASHLCKQKEIEMTQKKMTSEVSVSHEKEKDLLHKNQRL---QDEVAVLRLEMDTIKSHNQEKEKRY--LEDIKI 920
Cdd:TIGR02168 420 QQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALeelREELEEAEQALDAAERELAQLQARLdsLERLQE 499
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 921 ANEKNDNLQRMVKLNEETFTktifQYTGQLNSL--------KAENTMLSSKL-----DNEKQNKERLETDVESFRSR--- 984
Cdd:TIGR02168 500 NLEGFSEGVKALLKNQSGLS----GILGVLSELisvdegyeAAIEAALGGRLqavvvENLNAAKKAIAFLKQNELGRvtf 575
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 985 LASALHDHAEIQTAKRDL---EIAFQRARDEWFRVKDKMNFDMSNLRDNNEVLSQQLSKTE-RKLNSLEIEFHHTKDEL- 1059
Cdd:TIGR02168 576 LPLDSIKGTEIQGNDREIlknIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVDDLDNALElAKKLRPGYRIVTLDGDLv 655
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1060 -REKTLALKHAQRDLSqTQCQMKEVEHMfqdeQGKVSKFMGKQESIEERLAQLQSENTLLRQQLDDAANKAESKDKTIVN 1138
Cdd:TIGR02168 656 rPGGVITGGSAKTNSS-ILERRREIEEL----EEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISA 730
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1139 IQDQFQDVLTRFQAESQRHSlRLEDRNQELVSECSHLRERLCQYENEKAEREVVVRQLQQELADTLK-KQSMSEASLEVS 1217
Cdd:TIGR02168 731 LRKDLARLEAEVEQLEERIA-QLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEeLKALREALDELR 809
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1218 SRYRsNLEEEARDLKKKLGQLRSQLQEARDQHREAVHHAEKMEDHLQKLELEKSKFEITIKKQSEEIDQLQenlsrvNLS 1297
Cdd:TIGR02168 810 AELT-LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALL------NER 882
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1298 EEDKEKLQKLTELKESLECTVDQEQKRSSALEKELAEFKEVLKMTKKELNEYENRELNLRQDIKNNH-LEMDIPVsTLIK 1376
Cdd:TIGR02168 883 ASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYsLTLEEAE-ALEN 961
|
730
....*....|
gi 124487433 1377 KIDDLTAKLE 1386
Cdd:TIGR02168 962 KIEDDEEEAR 971
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
1056-1566 |
5.77e-16 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 84.22 E-value: 5.77e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1056 KDELREKTLALKHAQRDLSQTQCQMKEVEHmfQDEQGKVSKFMGKQESIEERLAQLQSENTLLRQQLDDAANKAESKDKT 1135
Cdd:COG1196 219 KEELKELEAELLLLKLRELEAELEELEAEL--EELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAE 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1136 IVNIQDQFQDVLTRFQAESQRhSLRLEDRNQELVSECSHLRERLCQYENEKAEREVVVRQLQQELADTLKKQSMSEASLE 1215
Cdd:COG1196 297 LARLEQDIARLEERRRELEER-LEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELA 375
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1216 VSSRYRSNLEEEARDLKKKLGQLRSQLQEARDQHREAVHHAEKMEDHLQKLELEKSKFEITIKKQSEEIDQLQENLSRvn 1295
Cdd:COG1196 376 EAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAE-- 453
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1296 LSEEDKEKLQKLTELKESLEctvdQEQKRSSALEKELAEFKEVLKMTKKELNEYENRELN-LRQDIKNNHLEMDIPVSTL 1374
Cdd:COG1196 454 LEEEEEALLELLAELLEEAA----LLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGvKAALLLAGLRGLAGAVAVL 529
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1375 IKKIDDLTAKLETASS---------------KCLHLGKKNQLLQQELLLMRTIQkkcgKLEKNKKQLEQEVVNLRSHMEK 1439
Cdd:COG1196 530 IGVEAAYEAALEAALAaalqnivveddevaaAAIEYLKAAKAGRATFLPLDKIR----ARAALAAALARGAIGAAVDLVA 605
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1440 NMVEHSQAQQYAREVEERARQDLVEKLKQVNLFLQAQAASQESLEQLRENSNASVRSQMELRIKDLESQLYRMKAQEDFD 1519
Cdd:COG1196 606 SDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELA 685
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 124487433 1520 KIELEKYKQLYQEEFRARKSLSSKLNKTSEKLEEASSKLLLEEQQNR 1566
Cdd:COG1196 686 ERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEA 732
|
|
| SMC_prok_B |
TIGR02168 |
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ... |
1028-1391 |
6.44e-15 |
|
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain] Cd Length: 1179 Bit Score: 80.87 E-value: 6.44e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1028 RDNNEVLSQQLSKTERKLNSLEI------EFHHTKDELREKTLAL-----KHAQRDLSQTQCQMKEVEHMFQDEQGKVSK 1096
Cdd:TIGR02168 185 RENLDRLEDILNELERQLKSLERqaekaeRYKELKAELRELELALlvlrlEELREELEELQEELKEAEEELEELTAELQE 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1097 FMGKQESIEERLAQLQSENTLLRQQLDDAANKAESKDKTIVNIQDQFQdvltrfqaesqrhslRLEDRNQELVSECSHLR 1176
Cdd:TIGR02168 265 LEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLA---------------NLERQLEELEAQLEELE 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1177 ERLCQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVSSRYRSNLEEEARDLKKKLGQLRSQLQEARDQHREavhha 1256
Cdd:TIGR02168 330 SKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIER----- 404
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1257 ekMEDHLQKLELEKSKFEITIKKQSEEIDQLQENLSRVNLSEEDKEklqkLTELKESLECTVDQEqkrsSALEKELAEFK 1336
Cdd:TIGR02168 405 --LEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEE----LEELQEELERLEEAL----EELREELEEAE 474
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 124487433 1337 EVLKMTKKELNEYENReLNLRQDIKNNHLEMDIPVSTLIKKIDDLTAKLETASSK 1391
Cdd:TIGR02168 475 QALDAAERELAQLQAR-LDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSEL 528
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
41-210 |
1.21e-14 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 78.53 E-value: 1.21e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 41 YHIHDKDMGKIHKAASVGDVAKVQHILILGkSGVNDRDKKDRTALHLACAYGHP---EVVTLLVERKCEIDARDSESSTA 117
Cdd:PHA03095 8 DIIMEAALYDYLLNASNVTVEEVRRLLAAG-ADVNFRGEYGKTPLHLYLHYSSEkvkDIVRLLLEAGADVNAPERCGFTP 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 118 LIKAVQCQ-EEECAAILLDHGADPNVMDSSGNTALHyaVY----SENTSMAAKLLAHNANIEAKNKDDLTPMLLAVKENK 192
Cdd:PHA03095 87 LHLYLYNAtTLDVIKLLIKAGADVNAKDKVGRTPLH--VYlsgfNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRN 164
|
170 180
....*....|....*....|
gi 124487433 193 QHI--VEFLVKKKASIHAVD 210
Cdd:PHA03095 165 ANVelLRLLIDAGADVYAVD 184
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
51-204 |
2.31e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 77.34 E-value: 2.31e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 51 IHKAASVGDVAKVQHILILGKSGVNDRDKKDRTALHLACAYGHPEVVTLLVERKCEIDARDSESSTALIKAVQCQEEECA 130
Cdd:PHA02875 72 LHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGI 151
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124487433 131 AILLDHGADPNVMDSSGNTALHYAVYSENTSMAAKLLAHNANIEAKNKD-DLTPMLLAVKENKQHIVEFLVKKKA 204
Cdd:PHA02875 152 ELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNgCVAALCYAIENNKIDIVRLFIKRGA 226
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
740-1244 |
3.56e-14 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 78.29 E-value: 3.56e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 740 SETEEVKSRLEHEKVGWEQELCRLRFALKQEEEKRRSADQLSEKTSEQLRRKGEQCQSEVEARQQLEASLRTLEMELKTV 819
Cdd:pfam01576 57 AEAEEMRARLAARKQELEEILHELESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKL 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 820 KSHLNqVLEERNEtqrQLSREQNARMLQDGILASHLCKQKE--IEMTQKKMTSEVSVSHEKEKDLLHKNQRLQDEVAVLR 897
Cdd:pfam01576 137 EEDIL-LLEDQNS---KLSKERKLLEERISEFTSNLAEEEEkaKSLSKLKNKHEAMISDLEERLKKEEKGRQELEKAKRK 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 898 LEMDTIKSHNQEKE-KRYLEDIKIAN-EKNDNLQR-MVKLNEETFTKTIFQytGQLNSLKAENTMLSSKLDNEKQNKER- 973
Cdd:pfam01576 213 LEGESTDLQEQIAElQAQIAELRAQLaKKEEELQAaLARLEEETAQKNNAL--KKIRELEAQISELQEDLESERAARNKa 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 974 ------LETDVESFRSRLASALHDHAEIQT--AKRDLEIA-FQRARDEWFRVKDKMNFDMSNLRDNN-EVLSQQLSKTER 1043
Cdd:pfam01576 291 ekqrrdLGEELEALKTELEDTLDTTAAQQElrSKREQEVTeLKKALEEETRSHEAQLQEMRQKHTQAlEELTEQLEQAKR 370
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1044 KLNSLEIEFHHTKDELREKTLALKHAQRDLSQTQCQMKEVEHMFQDEQGKVSKFMGKQESIEERLAQLQSENTLLRQQLD 1123
Cdd:pfam01576 371 NKANLEKAKQALESENAELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLN 450
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1124 DAANKAESKDKTIVNIQDQFQDVLTRFQAESqRHSLRLEDRNQELVSECSHLRERLCQYENEKAEREVVVRQLQQELADT 1203
Cdd:pfam01576 451 EAEGKNIKLSKDVSSLESQLQDTQELLQEET-RQKLNLSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDM 529
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 124487433 1204 LKKQSMSEASLEVssryrsnLEEEARDLKKKLGQLRSQLQE 1244
Cdd:pfam01576 530 KKKLEEDAGTLEA-------LEEGKKRLQRELEALTQQLEE 563
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
66-226 |
8.89e-14 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 75.83 E-value: 8.89e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 66 ILILGKSGVNDRDKKDRTALHLACAYGHP--EVVTLLVERKCEIDARDSESSTAL-IKAVQCQeeeCAAI----LLDHGA 138
Cdd:PHA03095 172 LLIDAGADVYAVDDRFRSLLHHHLQSFKPraRIVRELIRAGCDPAATDMLGNTPLhSMATGSS---CKRSlvlpLLIAGI 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 139 DPNVMDSSGNTALHYAVYSENTSMAAKLLAHNANIEAKNKDDLTPMLLAVKENKQHIVEFLVKKKASIHAV----DQLGS 214
Cdd:PHA03095 249 SINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETVaatlNTASV 328
|
170
....*....|..
gi 124487433 215 NRQMFEYDGKRL 226
Cdd:PHA03095 329 AGGDIPSDATRL 340
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
707-1334 |
2.24e-13 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 75.74 E-value: 2.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 707 YKRL-IELKRSHCELLTGKLKRMENKYKGLQKEMSETEEVKSRLEHEKVGWEQELCRLRFALKQEEEKRRSADQLSEKTS 785
Cdd:COG1196 215 YRELkEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELL 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 786 EQLRRKGEQCQSEVEARQQLEASLRTLEMELKTVKSHLNQVLEERNETQRQLSREQNARMLqdgilashlcKQKEIEMTQ 865
Cdd:COG1196 295 AELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEE----------AEAELAEAE 364
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 866 KKMTSEVSVSHEKEKDLLHKNQRLQDEVAVLRLEMDTIKSHNQEKEKRYLEDIKIANEKNDNLQRMVKLNEEtftktifq 945
Cdd:COG1196 365 EALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEE-------- 436
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 946 ytgqlnsLKAENTMLSSKLDNEKQNKERLETDVESFRSRLASALHDHAEIQTAKRDLEIAFQRARDEwfrvkdkmnfdmS 1025
Cdd:COG1196 437 -------EEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLL------------L 497
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1026 NLRDNNEVLSQQLSKTERKLNSLEIefHHTKDELREKTLALKHAQRDLSQTQCQMKEVEhmfQDEQGKvskfmgkqESIE 1105
Cdd:COG1196 498 EAEADYEGFLEGVKAALLLAGLRGL--AGAVAVLIGVEAAYEAALEAALAAALQNIVVE---DDEVAA--------AAIE 564
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1106 ERLAQLQSENTLLrqqlddAANKAESKDKTIVNIQDQFQDVLTRFQAESQRHSLRLEDRNQELVSECSHLRERLCQYENE 1185
Cdd:COG1196 565 YLKAAKAGRATFL------PLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRR 638
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1186 KAEREVVVRQLQQELADTLKKQSMSEASLEVSSRYRSNLEEEARDLKKKLGQLRSQLQEARDQHREAVHHAEKMEDHLQK 1265
Cdd:COG1196 639 AVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLE 718
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124487433 1266 LELEKSKFEITIKKQSEEIDQLQEnlsrvnlsEEDKEKLQKLTELKESLEcTVDQEQKRSSALEKELAE 1334
Cdd:COG1196 719 EELEEEALEEQLEAEREELLEELL--------EEEELLEEEALEELPEPP-DLEELERELERLEREIEA 778
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
1093-1460 |
3.44e-13 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 75.10 E-value: 3.44e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1093 KVSKFMGKQESIEERLAQLQSENTLLRQQLDDAANKAESKDKtivniqdqFQDVLTRFQaesqrhslrlEDRNQELVSEC 1172
Cdd:TIGR02169 171 KKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAER--------YQALLKEKR----------EYEGYELLKEK 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1173 SHLRERLCQYENEKAEREVVVRQLQQELADTLKKQSMSEASL-EVSSRYRSNLEEEARDLKKKLGQLRSQLQEARDQHRE 1251
Cdd:TIGR02169 233 EALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLeELNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAE 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1252 AVHHAEKMEDHLQKLELEKSKFEITIKKQSEEIDqlQENLSRVNLSEEDKEKLQKLTELKESLEctvdQEQKRSSALEKE 1331
Cdd:TIGR02169 313 KERELEDAEERLAKLEAEIDKLLAEIEELEREIE--EERKRRDKLTEEYAELKEELEDLRAELE----EVDKEFAETRDE 386
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1332 LAEFKEVLKMTKKELNEYENRELNL-----RQDIKNNHLEMDIPVstLIKKIDDLTAKLETASSKclhlgkknqllqqel 1406
Cdd:TIGR02169 387 LKDYREKLEKLKREINELKRELDRLqeelqRLSEELADLNAAIAG--IEAKINELEEEKEDKALE--------------- 449
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 124487433 1407 llmrtIQKKCGKLEKNKKQL---EQEVVNLRSHMEKNMVEHSQAQQYAREVEERARQ 1460
Cdd:TIGR02169 450 -----IKKQEWKLEQLAADLskyEQELYDLKEEYDRVEKELSKLQRELAEAEAQARA 501
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
724-1561 |
4.79e-13 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 74.72 E-value: 4.79e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 724 KLKRMENKYKGLQKEMSETEEVKSRLEHEKVGWEQELCRLRFALKQEEEKRRSADQLSEKTSEQLRRKGEQCQSEVEAR- 802
Cdd:TIGR02169 217 LKEKREYEGYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKi 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 803 QQLEASLRTLEMELKTVKSHLNQVLEERNETQRQLSReqnarmlqdgilashlcKQKEIEMTQKKMTSEvsvshEKEKDl 882
Cdd:TIGR02169 297 GELEAEIASLERSIAEKERELEDAEERLAKLEAEIDK-----------------LLAEIEELEREIEEE-----RKRRD- 353
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 883 lhknqRLQDEVAVLRLEMDTIKSHNQEKEKRYlediKIANEKNDNLQrmvklneetftKTIFQYTGQLNSLKAEntmlss 962
Cdd:TIGR02169 354 -----KLTEEYAELKEELEDLRAELEEVDKEF----AETRDELKDYR-----------EKLEKLKREINELKRE------ 407
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 963 kLDNEKQNKERLETDVESFRSRLASALHDHAEIQTAKRDLEIAFQRARDEWFRVKDKMnfdmsnlrdnnEVLSQQLSKTE 1042
Cdd:TIGR02169 408 -LDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADL-----------SKYEQELYDLK 475
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1043 RKLNSLEIEFHhtkdELREKTLALKHAQRDLSQTQCQMKEVEHMFQDEQGKVSKFMGKQESIEER--------------- 1107
Cdd:TIGR02169 476 EEYDRVEKELS----KLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGERyataievaagnrlnn 551
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1108 -------------------------------LAQLQSENTLLRQQ--LDDAANKAESKDKTIVNIQDQFQDVLTRFQAES 1154
Cdd:TIGR02169 552 vvveddavakeaiellkrrkagratflplnkMRDERRDLSILSEDgvIGFAVDLVEFDPKYEPAFKYVFGDTLVVEDIEA 631
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1155 QRH---SLRLEDRNQELVSECSHL----RERLCQYENEKAEREVVvrqlqQELADTLKKQSMSEASLEVSSRYRSNLEEE 1227
Cdd:TIGR02169 632 ARRlmgKYRMVTLEGELFEKSGAMtggsRAPRGGILFSRSEPAEL-----QRLRERLEGLKRELSSLQSELRRIENRLDE 706
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1228 AR----DLKKKLGQLRSQLQEARDQHREAVHHAEKMEDHLQKLELEKSKFEITIKKQSEEIDQLQENLSRVNLSEED--- 1300
Cdd:TIGR02169 707 LSqelsDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDlea 786
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1301 ---KEKLQKLTELKESLECTVDQEQKRSSALEKELAEFKEVLKMTKKELNEYENRELNLRQDIKNNHLEMDipvsTLIKK 1377
Cdd:TIGR02169 787 rlsHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIE----NLNGK 862
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1378 IDDLTAKLETASSKCLHLGKKNQLLQQELLLMrtiQKKCGKLEKNKKQLEQEVVNLRSHMEKNMVEHSQAQQYAREVEER 1457
Cdd:TIGR02169 863 KEELEEELEELEAALRDLESRLGDLKKERDEL---EAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDP 939
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1458 ARQDL--------VEKLKQVNLFLQAQAASQESLEQLRENSNASVrsqmELRIKDLESQLYRMKAQEDFDKIELEKYKQL 1529
Cdd:TIGR02169 940 KGEDEeipeeelsLEDVQAELQRVEEEIRALEPVNMLAIQEYEEV----LKRLDELKEKRAKLEEERKAILERIEEYEKK 1015
|
890 900 910
....*....|....*....|....*....|...
gi 124487433 1530 YQEEF-RARKSLSSKLNKTSEKLEEASSKLLLE 1561
Cdd:TIGR02169 1016 KREVFmEAFEAINENFNEIFAELSGGTGELILE 1048
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
62-210 |
5.19e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 73.16 E-value: 5.19e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 62 KVQHILILGKSGVNDRDKKDRTALHLACAYGHPEVVTLLVERKCEIDARDSESSTAL-----IKAVQCQEEECAAILLDH 136
Cdd:PHA03100 16 KNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLhylsnIKYNLTDVKEIVKLLLEY 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124487433 137 GADPNVMDSSGNTALHYAVY--SENTSMAAKLLAHNANIEAKNKDDLTPMLLAVK--ENKQHIVEFLVKKKASIHAVD 210
Cdd:PHA03100 96 GANVNAPDNNGITPLLYAISkkSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLEsnKIDLKILKLLIDKGVDINAKN 173
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
766-1337 |
3.15e-12 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 71.89 E-value: 3.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 766 ALKQEEEKR---------RSADQLSEKTSEQLRRKGEQCQSEVEARQQLEASLRTLEMELKTVKSHLNQVLEERNETQRQ 836
Cdd:COG1196 217 ELKEELKELeaellllklRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAE 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 837 LSREQNARMLQDGilashlcKQKEIEMTQKKMTSEVSVSHEKEKDLLHKNQRLQDEVAVLRLEMDTIKSHNQEKEKRYLE 916
Cdd:COG1196 297 LARLEQDIARLEE-------RRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLE 369
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 917 DIKIANEKNDNLQRmvklneetFTKTIFQYTGQLNSLKAENTMLSSKLDNEKQNKERLETDVESFRSRLASALHDHAEIQ 996
Cdd:COG1196 370 AEAELAEAEEELEE--------LAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEE 441
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 997 TAKRDLEIAFQRARDEwfrvkdkmnfdmsnlRDNNEVLSQQLSKTERKLNSLEIEFHHTKDELREKTLALKHAQRDLSQT 1076
Cdd:COG1196 442 EALEEAAEEEAELEEE---------------EEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGF 506
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1077 QCQMKEVEHmfQDEQGKVSKFMGKQESIEERLAQLQsENTLLRQQLDDAANKAESKDKTIVNIQDQFQDVLTRFQAES-Q 1155
Cdd:COG1196 507 LEGVKAALL--LAGLRGLAGAVAVLIGVEAAYEAAL-EAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKiR 583
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1156 RHSLRLEDRNQELVSECSHLRERLCQYENEKAER---EVVVRQLQQELADTLKKQSMS------EASLEVSSRYRSNLEE 1226
Cdd:COG1196 584 ARAALAAALARGAIGAAVDLVASDLREADARYYVlgdTLLGRTLVAARLEAALRRAVTlagrlrEVTLEGEGGSAGGSLT 663
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1227 EARDLKKKLGQLRSQLQEARDQHREAVHHAEKMEDHLQKLELEKSKFEITIKKQSEEIDQLQENLSRVNLSEEDKEKLQK 1306
Cdd:COG1196 664 GGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLE 743
|
570 580 590
....*....|....*....|....*....|.
gi 124487433 1307 LTELKESLECTVDQEQKRSSALEKELAEFKE 1337
Cdd:COG1196 744 EEELLEEEALEELPEPPDLEELERELERLER 774
|
|
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
767-1428 |
4.41e-12 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 71.54 E-value: 4.41e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 767 LKQEEEKRRSADQLSEKTSEQLRRKGEQcQSEVEARQQLEASLRTLEMELKTVKSHLNQVLEERNEtQRQLSReqnarml 846
Cdd:TIGR00618 224 LEKELKHLREALQQTQQSHAYLTQKREA-QEEQLKKQQLLKQLRARIEELRAQEAVLEETQERINR-ARKAAP------- 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 847 qdgiLASHLCKQKEIEMTQKKMTSEVSVSHEKEKDLLHKNQRLQDEVAVLRLEMDTIKSHNQEKEKryledIKIANEKnD 926
Cdd:TIGR00618 295 ----LAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIH-----IRDAHEV-A 364
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 927 NLQRMVKLNEETFTKTIFQYTGQLNSLKAENTMLSSKLDNEKQNKERLETDVESFRSRLASALHDHAEIQTAKRDLEIAF 1006
Cdd:TIGR00618 365 TSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCA 444
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1007 QRARDEWFRVKDKmNFDMSNLRDNNEVLSQQLSKTE---RKLNSLEIEFHHTKDELREKTLALKHAQRDLSQ-------- 1075
Cdd:TIGR00618 445 AAITCTAQCEKLE-KIHLQESAQSLKEREQQLQTKEqihLQETRKKAVVLARLLELQEEPCPLCGSCIHPNParqdidnp 523
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1076 --TQCQMKEVEHMFQDEQGKVSKFMGKQESIEERLAQLQSENTLLRQQLDDAANKAESKDKTIVNIQDQFQDVLTRFQAE 1153
Cdd:TIGR00618 524 gpLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKL 603
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1154 SQ-RHSLRLEDRNQELVSECSHLRERLCQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEV------SSRYRSNLEE 1226
Cdd:TIGR00618 604 SEaEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHALQLTLTQERVREHALSIrvlpkeLLASRQLALQ 683
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1227 EARDLKKKLGQLRSQLQEARDQHREAVHHAEKMEDHLQKLELEKSKFEITIKKQSEEIDQLQENLSRvnlseEDKEKLQK 1306
Cdd:TIGR00618 684 KMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMH-----QARTVLKA 758
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1307 LTELKE--SLECTVD-QEQKRSSALEKELAEFKEVLKMTKKELNEYENRelnLRQDIKNNHLEMDIPVSTLIKKIDDLTA 1383
Cdd:TIGR00618 759 RTEAHFnnNEEVTAAlQTGAELSHLAAEIQFFNRLREEDTHLLKTLEAE---IGQEIPSDEDILNLQCETLVQEEEQFLS 835
|
650 660 670 680
....*....|....*....|....*....|....*....|....*
gi 124487433 1384 KLETASSKclhlgkknqllqqelllMRTIQKKCGKLEKNKKQLEQ 1428
Cdd:TIGR00618 836 RLEEKSAT-----------------LGEITHQLLKYEECSKQLAQ 863
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
1027-1507 |
5.16e-12 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 71.22 E-value: 5.16e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1027 LRDNNEVLSQQLSKTERK--------LNSLEIEFHHTKDEL------REKTLALKHAQRDL----SQTQCQMKEVEHMFQ 1088
Cdd:PRK02224 182 LSDQRGSLDQLKAQIEEKeekdlherLNGLESELAELDEEIeryeeqREQARETRDEADEVleehEERREELETLEAEIE 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1089 DEQGKVSKFMGKQESIEERLAQLQSENTLLRQQLDDAANKAESKDKTIVNIQDQFQDVLTRF------------------ 1150
Cdd:PRK02224 262 DLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDeelrdrleecrvaaqahn 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1151 -QAESQRHS-LRLEDRNQELVSECSHLRERLCQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVSSRYRSNLEEEA 1228
Cdd:PRK02224 342 eEAESLREDaDDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREER 421
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1229 RDLKKKLGQLRSQLQEARDQHREA---------------------VHHAEKMEDHLQKLELEKSKFEITI---------- 1277
Cdd:PRK02224 422 DELREREAELEATLRTARERVEEAealleagkcpecgqpvegsphVETIEEDRERVEELEAELEDLEEEVeeveerlera 501
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1278 ---KKQSEEIDQLQENLSRVN--------LSEEDKEKLQKLTELKESLECTVDQEQKRSSALEKELAEFKEVLKMTKKEL 1346
Cdd:PRK02224 502 edlVEAEDRIERLEERREDLEeliaerreTIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKL 581
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1347 NEYENRELNLRQdiknnhlemdipVSTLIKKIDDLTAKLETASSKCLHLGKKNQLLQQELLLMRTiqkkcgklekNKKQL 1426
Cdd:PRK02224 582 AELKERIESLER------------IRTLLAAIADAEDEIERLREKREALAELNDERRERLAEKRE----------RKREL 639
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1427 EQEVVNLRshMEKNMVEHSQAQQYAREVEERARQdLVEKLKQVNLFLQAQAASQESLEQLRENsnasvRSQMELRIKDLE 1506
Cdd:PRK02224 640 EAEFDEAR--IEEAREDKERAEEYLEQVEEKLDE-LREERDDLQAEIGAVENELEELEELRER-----REALENRVEALE 711
|
.
gi 124487433 1507 S 1507
Cdd:PRK02224 712 A 712
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
859-1386 |
7.54e-12 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 70.74 E-value: 7.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 859 KEIEMTQKKMTSEVSVSHEKEKDLLHKNQRLQDEVAVLRLEMDTI-KSHNQEKEKRYLEDIKIANEKNDNLQRMVKLNEE 937
Cdd:COG1196 235 RELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELeLELEEAQAEEYELLAELARLEQDIARLEERRREL 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 938 TftktifqytGQLNSLKAENTMLSSKLDNEKQNKERLETDVESFRSRLASALHDHAEIQTAKRDLEIAFQRARDEWFRVK 1017
Cdd:COG1196 315 E---------ERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELA 385
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1018 DkmnfDMSNLRDNNEVLSQQLSKTERKLNSLEIEFHHTKDELREKTLALKHAQRDLSQTQCQMKEVEHMFQDEQGKVSKF 1097
Cdd:COG1196 386 E----ELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEAL 461
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1098 MGKQESIEERLAQLQSENTLLRQQLDDAANKAESKDKTIVNIQDQFQDVLTRFQAESQRHSLRLEDRNQELVSEC-SHLR 1176
Cdd:COG1196 462 LELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYeAALE 541
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1177 ERLCQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVSSRYRSN---------------LEEEARDLKKKLGQLRSQ 1241
Cdd:COG1196 542 AALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALaaalargaigaavdlVASDLREADARYYVLGDT 621
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1242 LQEARDQHREAVHHAEKMEDHLQKLE-------------LEKSKFEITIKKQSEEIDQLQENLSRVNLSEEDKEKLQKLT 1308
Cdd:COG1196 622 LLGRTLVAARLEAALRRAVTLAGRLRevtlegeggsaggSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLA 701
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124487433 1309 ELKESLECTVDQEQKRSSALEKELAEFKEVLKMTKKELNEYENRELNLRQDIKNNHLEMDIpvSTLIKKIDDLTAKLE 1386
Cdd:COG1196 702 EEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDL--EELERELERLEREIE 777
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
721-1360 |
7.87e-12 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 70.48 E-value: 7.87e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 721 LTGKLKRM-ENKYKGLQKEMSETEEVKSRLEHEKVGWEQELCRLRFALKQEEEKRRS----ADQLSEKTSEQLRRKgEQC 795
Cdd:TIGR02169 277 LNKKIKDLgEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKllaeIEELEREIEEERKRR-DKL 355
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 796 QSEVEAR-----------QQLEASLRTLEMELKTVKSHLNQVLEERNETQRQLSREQ-----------NARMLQDGILAS 853
Cdd:TIGR02169 356 TEEYAELkeeledlraelEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQeelqrlseelaDLNAAIAGIEAK 435
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 854 HL-------CKQKEI-EMTQKKMTSEVSVSHEKEK--DLLHKNQRLQDEVAVLRLEMDTIKSHNQEKEKRYLEDIKIANE 923
Cdd:TIGR02169 436 INeleeekeDKALEIkKQEWKLEQLAADLSKYEQElyDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEV 515
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 924 KNDNLQ-------RMVKLNEETFTKTIFQYTGQLNS---------------LKAEN----TMLS-SKLDNEKQNKERLET 976
Cdd:TIGR02169 516 LKASIQgvhgtvaQLGSVGERYATAIEVAAGNRLNNvvveddavakeaielLKRRKagraTFLPlNKMRDERRDLSILSE 595
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 977 DV------------ESFRSRLASALHDH---AEIQTAKRDLEIA---------FQR--ARDEWFRVKDKMNFDMSNLRDN 1030
Cdd:TIGR02169 596 DGvigfavdlvefdPKYEPAFKYVFGDTlvvEDIEAARRLMGKYrmvtlegelFEKsgAMTGGSRAPRGGILFSRSEPAE 675
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1031 NEVLSQQLSKTERKLNSLEIEFHHTKDELREKTLALKHAQRDLSQTQcqmKEVEHMFQDEQgkvsKFMGKQESIEERLAQ 1110
Cdd:TIGR02169 676 LQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIE---KEIEQLEQEEE----KLKERLEELEEDLSS 748
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1111 LQSENTLLRQQLDDAANKAESKDKTIVNIQDQFQDVLTR----FQAESQRHSLRLEDRNQELVSECSHLRERLCQYENEK 1186
Cdd:TIGR02169 749 LEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARlshsRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEK 828
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1187 AEREVVVRQLQQELADTLKKQSMSEASLEVSSRYRSNLEEEARDLKKKLGQLRSQLQEARDQHREAVHHAEKMEDHLQKL 1266
Cdd:TIGR02169 829 EYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEEL 908
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1267 ELEKSKFEITIKKQSEEIDQLQENLSRV-------------NLSEED-KEKLQKLTELKESLE---CTVDQEQKRSSALE 1329
Cdd:TIGR02169 909 EAQIEKKRKRLSELKAKLEALEEELSEIedpkgedeeipeeELSLEDvQAELQRVEEEIRALEpvnMLAIQEYEEVLKRL 988
|
730 740 750
....*....|....*....|....*....|.
gi 124487433 1330 KELAEFKEVLKMTKKELNEYENRELNLRQDI 1360
Cdd:TIGR02169 989 DELKEKRAKLEEERKAILERIEEYEKKKREV 1019
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
790-1515 |
1.38e-11 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 69.82 E-value: 1.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 790 RKGEQCQSEVEARQQLEASLRTLEMELKTVKSHLNQVLEERNETQRQLSREQNARMLQDGILASHLCKQKEIEMTQKKMT 869
Cdd:pfam01576 2 RQEEEMQAKEEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQAETELCAEAEEMRARLAARKQELEEILHELE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 870 SEVSVSHEKEKDLLHKNQRLQDEVAVLRLEMDTIKSHNQE----------KEKRYLEDIKIANEKNDNLQRMVKLNEEtf 939
Cdd:pfam01576 82 SRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKlqlekvtteaKIKKLEEDILLLEDQNSKLSKERKLLEE-- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 940 tkTIFQYTGQLnslkAENTMLSSKLDNEKQNKERLETDVEsfrSRLASALHDHAEIQTAKRDLEIAFQRARDEwfrvkdk 1019
Cdd:pfam01576 160 --RISEFTSNL----AEEEEKAKSLSKLKNKHEAMISDLE---ERLKKEEKGRQELEKAKRKLEGESTDLQEQ------- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1020 mnfdMSNLRDNNEVLSQQLSKTERKLNSLEiefhhtkDELREKTLALKHAQRDLSQTQCQMKEVEHMFQDEQGKVSKFMG 1099
Cdd:pfam01576 224 ----IAELQAQIAELRAQLAKKEEELQAAL-------ARLEEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEK 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1100 KQESIEERLAQLQSEntlLRQQLDDAANKAESKDKtivniQDQFQDVLTR-FQAESQRHSLRLEDRNQELVSECSHLRER 1178
Cdd:pfam01576 293 QRRDLGEELEALKTE---LEDTLDTTAAQQELRSK-----REQEVTELKKaLEEETRSHEAQLQEMRQKHTQALEELTEQ 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1179 LCQYENEKAEREVVVRQLQQELADTlkkqsmsEASLEVSSRYRSNLEEEARDLKKKLGQLRSQLQEARDQHREAVHHAEK 1258
Cdd:pfam01576 365 LEQAKRNKANLEKAKQALESENAEL-------QAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSK 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1259 MEDHLQKLELEKSKFEITIKKQSEEIDQLQENLSRVN--LSEEDKEKLQ------KLTELKESLECTVDQEQKRSSALEK 1330
Cdd:pfam01576 438 LQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQelLQEETRQKLNlstrlrQLEDERNSLQEQLEEEEEAKRNVER 517
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1331 ELAEFKEVLKMTKKELNEYENRELNLRQDIKNnhlemdipvstLIKKIDDLTAKLETASSKCLHLGKKNQLLQQELLLMR 1410
Cdd:pfam01576 518 QLSTLQAQLSDMKKKLEEDAGTLEALEEGKKR-----------LQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLL 586
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1411 TIQKK----CGKLEKNKKQLEQEVVNLRSHMEKNMVEHSQAQQYAREVE------ERARQDLVEKLKQVNLFLQAQAASQ 1480
Cdd:pfam01576 587 VDLDHqrqlVSNLEKKQKKFDQMLAEEKAISARYAEERDRAEAEAREKEtralslARALEEALEAKEELERTNKQLRAEM 666
|
730 740 750
....*....|....*....|....*....|....*
gi 124487433 1481 ESLEQLRENSNASVRsQMELRIKDLESQLYRMKAQ 1515
Cdd:pfam01576 667 EDLVSSKDDVGKNVH-ELERSKRALEQQVEEMKTQ 700
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
725-1510 |
1.46e-11 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 69.76 E-value: 1.46e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 725 LKRMENKYKGLQKEMSETEEVKsrlEHEKVGWEQELCRLRFALKQEEEKRrsaDQLSEktseqLRRKGEQCQSEVeaRQQ 804
Cdd:pfam15921 80 LEEYSHQVKDLQRRLNESNELH---EKQKFYLRQSVIDLQTKLQEMQMER---DAMAD-----IRRRESQSQEDL--RNQ 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 805 LEASLRtlemELKTVKSHLNQVLEERNETQRQLSReqnarmlqdgILASHLCKQKEI--------EMTQKKMTSEVSVSH 876
Cdd:pfam15921 147 LQNTVH----ELEAAKCLKEDMLEDSNTQIEQLRK----------MMLSHEGVLQEIrsilvdfeEASGKKIYEHDSMST 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 877 EKEKDL---LHKNQR-LQDEVAVLRL-------EMDTIKSHNQEKEKRYLEdikianEKNDNLQRMVKLNE---ETFTKT 942
Cdd:pfam15921 213 MHFRSLgsaISKILReLDTEISYLKGrifpvedQLEALKSESQNKIELLLQ------QHQDRIEQLISEHEveiTGLTEK 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 943 IFQYTGQLNSLKAENTMLSSKLDNEKQNKERLETDVESFRSRLASALHD-----HAEIQTAKRDLEIA---FQRARDEwf 1014
Cdd:pfam15921 287 ASSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREakrmyEDKIEELEKQLVLAnseLTEARTE-- 364
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1015 rvKDKMNFDMSNLRDNNEVLSQQLSKTERKLNSLEIEFHHTKDELREKTLALKHAQRDLSQTQCQMKEVEHMFQ----DE 1090
Cdd:pfam15921 365 --RDQFSQESGNLDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKamksEC 442
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1091 QGKVSKFM----GKQESIEE---RLAQLQSENTLLRQQLDDAANKA---ESKDKTIVNIQDQFQDVLTRFQAESQRHSlR 1160
Cdd:pfam15921 443 QGQMERQMaaiqGKNESLEKvssLTAQLESTKEMLRKVVEELTAKKmtlESSERTVSDLTASLQEKERAIEATNAEIT-K 521
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1161 LEDRNQELVSECSHLRERLCQYENEKAEREVVVRQLQQEladtlkkqsmsEASLEVssryrsnLEEEARDLKKKLGQlrs 1240
Cdd:pfam15921 522 LRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMAEK-----------DKVIEI-------LRQQIENMTQLVGQ--- 580
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1241 qlqEARDQHREAVHHAEkMEDHLQKLELEKSKFEITIKKQSEEIDQLQENLSRVNLseedkEKLQKLTELKESLECTVDQ 1320
Cdd:pfam15921 581 ---HGRTAGAMQVEKAQ-LEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLEL-----EKVKLVNAGSERLRAVKDI 651
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1321 EQKRSSALEKelaefkevLKMTKKELNEYENRELNLRQDIKNNHLEMDIPVSTLIKKIDDLTAKLETASSKCLHL-GKKN 1399
Cdd:pfam15921 652 KQERDQLLNE--------VKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMeGSDG 723
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1400 QLLQQELLLMRTIQKKCGKLE--KNKKQLEQEVV---NLRSHM---EKNMVEH------SQAQQYAREVEERARQDLVEK 1465
Cdd:pfam15921 724 HAMKVAMGMQKQITAKRGQIDalQSKIQFLEEAMtnaNKEKHFlkeEKNKLSQelstvaTEKNKMAGELEVLRSQERRLK 803
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|
gi 124487433 1466 LKQVNLFLQAQAASQESLE-----QLRENSNASVRSQMELRIKDLESQLY 1510
Cdd:pfam15921 804 EKVANMEVALDKASLQFAEcqdiiQRQEQESVRLKLQHTLDVKELQGPGY 853
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
41-211 |
1.57e-11 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 68.54 E-value: 1.57e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 41 YHIHDKDMgkihkaASVGDVAKVQHILILGKSGVNDRDKKDRTALHLACAY--GHPEVVTLLVERKCEIDARDSESSTAL 118
Cdd:PHA03100 72 LHYLSNIK------YNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLL 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 119 IKAVQC--QEEECAAILLDHGADPNVMDS----------------SGNTALHYAVYSENTSMAAKLLAHNANIEAKNKDD 180
Cdd:PHA03100 146 HLYLESnkIDLKILKLLIDKGVDINAKNRvnyllsygvpinikdvYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYG 225
|
170 180 190
....*....|....*....|....*....|.
gi 124487433 181 LTPMLLAVKENKQHIVEFLVKKKASIHAVDQ 211
Cdd:PHA03100 226 DTPLHIAILNNNKEIFKLLLNNGPSIKTIIE 256
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
54-277 |
1.97e-11 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 69.13 E-value: 1.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 54 AASVGDVAKVQHILILGKSGvNDRDKKDRTALHLACAYGHPEVVTLLVERKCEIDARDSESSTALIKAVQCQEEECAAIL 133
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDP-DIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRIL 610
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 134 --LDHGADPNvmdsSGNTALHYAVYSENTSMAAKLLAHNANIEAKNKDDLTPMLLAVKENKQHIVEFLVKKKASIHAV-- 209
Cdd:PLN03192 611 yhFASISDPH----AAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAnt 686
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124487433 210 DQLGSNRQMFEYDGKRlQRSENSNPVDNGSEDGSLTRSYNTPGPADSWPTSdeedynFDNKNVPKINL 277
Cdd:PLN03192 687 DDDFSPTELRELLQKR-ELGHSITIVDSVPADEPDLGRDGGSRPGRLQGTS------SDNQCRPRVSI 747
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
1100-1558 |
3.80e-11 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 68.17 E-value: 3.80e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1100 KQESIEERLAQLQSENTLLRQQLDDAANKAESKDKTIVNIQDQFQDVLTRFQaesqrhslRLEDRNQELVSECSHLRERL 1179
Cdd:PRK03918 159 DYENAYKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREIN--------EISSELPELREELEKLEKEV 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1180 CQYENEKAEREvvvrQLQQELADTLKKQSMSEASLEVSSRYRSNLEEEARDLKKKLGQLRSqLQEARDQHREAVHHAEKM 1259
Cdd:PRK03918 231 KELEELKEEIE----ELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKE-LKEKAEEYIKLSEFYEEY 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1260 EDHLQKLELEKSKFEITIKKQSEEIDQLQENLSRVN-LSEEDKEKLQKLTELKESLEC--TVDQEQKRSSALEKELAEfk 1336
Cdd:PRK03918 306 LDELREIEKRLSRLEEEINGIEERIKELEEKEERLEeLKKKLKELEKRLEELEERHELyeEAKAKKEELERLKKRLTG-- 383
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1337 EVLKMTKKELNEYENRELNLRQDIKNnHLEMDIPVSTLIKKIDDLTAKLETASSKCLHLGK------KNQLLQQELLLMR 1410
Cdd:PRK03918 384 LTPEKLEKELEELEKAKEEIEEEISK-ITARIGELKKEIKELKKAIEELKKAKGKCPVCGRelteehRKELLEEYTAELK 462
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1411 TIQKKCGKLEKNKKQLEQEVVNLRSHMEK------------------------NMVEHSQAQQYAREVEERARQ------ 1460
Cdd:PRK03918 463 RIEKELKEIEEKERKLRKELRELEKVLKKeseliklkelaeqlkeleeklkkyNLEELEKKAEEYEKLKEKLIKlkgeik 542
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1461 DLVEKLKQVNLFLQAQAASQESLEQLRENSNASVRSQMELRIKDLESQLYRMKAQEDFDK--IELEKYKQLYQEEFRARK 1538
Cdd:PRK03918 543 SLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEPFYNeyLELKDAEKELEREEKELK 622
|
490 500
....*....|....*....|
gi 124487433 1539 SLSSKLNKTSEKLEEASSKL 1558
Cdd:PRK03918 623 KLEEELDKAFEELAETEKRL 642
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
74-214 |
5.06e-11 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 66.91 E-value: 5.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 74 VNDRDKKDRTALHLACAYGHPEVVTLLVERKCEIDARDSESSTALIKAVQCQEEECAAILLDHGADPNVMDSSGNTALHY 153
Cdd:PHA02874 117 VNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHN 196
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 124487433 154 AVYSENTSMAAKLLAHNANIEAKNKDDLTPMLLAVKENKQhIVEFLVkKKASIHAVDQLGS 214
Cdd:PHA02874 197 AAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRS-AIELLI-NNASINDQDIDGS 255
|
|
| Mplasa_alph_rch |
TIGR04523 |
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
725-1387 |
6.70e-11 |
|
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.
Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 67.35 E-value: 6.70e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 725 LKRMENKYKGLQKEMSETEEVKSRLEHEKVGWEQELCRLRFALKQEEEKRRSADQLSEKTSEQLRRKGEQcqseveaRQQ 804
Cdd:TIGR04523 49 LKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQ-------KNK 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 805 LEASLRTLEMELKTVKSHLNQVLEERNETQRQLSREQNArmlqdgilASHLCKQKEIEMTQKKMTSEVSVSHEKEKDLLh 884
Cdd:TIGR04523 122 LEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNK--------YNDLKKQKEELENELNLLEKEKLNIQKNIDKI- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 885 KNQRLQDEVAVLRLEmdTIKSHNQEKEKRYLEDIKIANEKNDNLQRmvKLNEETFTKTIFQYT-GQLNSLKAENTMLSSK 963
Cdd:TIGR04523 193 KNKLLKLELLLSNLK--KKIQKNKSLESQISELKKQNNQLKDNIEK--KQQEINEKTTEISNTqTQLNQLKDEQNKIKKQ 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 964 LDNEKQNKERLETDVESFRsrlasalhdhAEIQTAKRDLEIAFQRARDEWFRvkdKMNFDMSNLRDNNEVLSQQLSKTER 1043
Cdd:TIGR04523 269 LSEKQKELEQNNKKIKELE----------KQLNQLKSEISDLNNQKEQDWNK---ELKSELKNQEKKLEEIQNQISQNNK 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1044 KLNSLEIEFHHTKDELREKTLALKHAQRDLSQTQCQMKEVEHmfqdeqgkvskfmgKQESIEERLAQLQSENTLLRQQLD 1123
Cdd:TIGR04523 336 IISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKK--------------ENQSYKQEIKNLESQINDLESKIQ 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1124 DAANKAESKDKTIVNIQDQFQdvltrfqaesqrhslRLEDRNQELVSECSHLRERLCQYENEKAEREVVVRQLQQeLADT 1203
Cdd:TIGR04523 402 NQEKLNQQKDEQIKKLQQEKE---------------LLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDN-TRES 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1204 LKKQsMSEASLEVSSrYRSNLEEEARDLKKK---LGQLRSQLQEARDQHREAVHHAEKMEDHLQKLELEKSKFEITIKKQ 1280
Cdd:TIGR04523 466 LETQ-LKVLSRSINK-IKQNLEQKQKELKSKekeLKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDL 543
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1281 SEEIDQLQENLSRVNLSEEDKEKLQKLTELKEslecTVDQEQKRSSALEKELAEFKEVLKMTKKELNEYENRELNLRQDI 1360
Cdd:TIGR04523 544 EDELNKDDFELKKENLEKEIDEKNKEIEELKQ----TQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKEL 619
|
650 660
....*....|....*....|....*..
gi 124487433 1361 KNNHLEMDiPVSTLIKKIDDLTAKLET 1387
Cdd:TIGR04523 620 EKAKKENE-KLSSIIKNIKSKKNKLKQ 645
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
721-1247 |
7.18e-11 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 67.45 E-value: 7.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 721 LTGKLKRMENKYKGLQKEMSETEEVKSRLEHEKVGWEQELCRLRFALKQEEEKRRSADQLSEKTSEQLRRKGEQCQSEVE 800
Cdd:pfam15921 375 LDDQLQKLLADLHKREKELSLEKEQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAIQ 454
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 801 ARQQLEASLRTLEMELKTVKSHLNQVLEERneTQRQLSREQNARMLQDgILASHLCKQKEIEMTQKKMTSEVSVSHEKEK 880
Cdd:pfam15921 455 GKNESLEKVSSLTAQLESTKEMLRKVVEEL--TAKKMTLESSERTVSD-LTASLQEKERAIEATNAEITKLRSRVDLKLQ 531
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 881 DLLH-KNQrlQDEVAVLRLEMDTIKSHNQEKEKRyledIKIANEKNDNLQRMVKLNEETFTKTIF---QYTGQLNSLK-- 954
Cdd:pfam15921 532 ELQHlKNE--GDHLRNVQTECEALKLQMAEKDKV----IEILRQQIENMTQLVGQHGRTAGAMQVekaQLEKEINDRRle 605
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 955 -AENTMLSSKLDNEKQNKERLETDVESFRSRLASA----LHDHAEIQTAKRDLEIAFQRARDEWFRVKDKMNFDMSNLRD 1029
Cdd:pfam15921 606 lQEFKILKDKKDAKIRELEARVSDLELEKVKLVNAgserLRAVKDIKQERDQLLNEVKTSRNELNSLSEDYEVLKRNFRN 685
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1030 NNEVLSQQLSKTERKLNSLEIEFHHTKDELR----------------EKTLALKHAQRDLSQTQCQMKEV--------EH 1085
Cdd:pfam15921 686 KSEEMETTTNKLKMQLKSAQSELEQTRNTLKsmegsdghamkvamgmQKQITAKRGQIDALQSKIQFLEEamtnankeKH 765
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1086 MFQDEQGKVSKFMGKQESIEERLA-QLQSENTLLRQQLDDAANKAESKDKTIVNIQdQFQDVLTRFQAESQR----HSLR 1160
Cdd:pfam15921 766 FLKEEKNKLSQELSTVATEKNKMAgELEVLRSQERRLKEKVANMEVALDKASLQFA-ECQDIIQRQEQESVRlklqHTLD 844
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1161 LEDRNQELVSECSHLRERLCQYENEKAEREVVVRQlqQELADTLKKQSMSEASLEvssryrsnlEEEARDLKKKLGQLRS 1240
Cdd:pfam15921 845 VKELQGPGYTSNSSMKPRLLQPASFTRTHSNVPSS--QSTASFLSHHSRKTNALK---------EDPTRDLKQLLQELRS 913
|
....*..
gi 124487433 1241 QLQEARD 1247
Cdd:pfam15921 914 VINEEPT 920
|
|
| DUF3584 |
pfam12128 |
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
994-1574 |
7.85e-11 |
|
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.
Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 67.56 E-value: 7.85e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 994 EIQTAKRDLEIAFQRARDEWFRVKDKMNFDMSNLRdnnevlsQQLSKTERKLNSLEiEFHHTKDELREKTLALKHAQRDL 1073
Cdd:pfam12128 280 ERQETSAELNQLLRTLDDQWKEKRDELNGELSAAD-------AAVAKDRSELEALE-DQHGAFLDADIETAAADQEQLPS 351
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1074 SQTQCQMKEVEH-MFQDEQGKVskfmgkQESIEERLAQLQSEN-TLLRQQLDDAANKAESKDKTIVNIQDQFQDVLTRFQ 1151
Cdd:pfam12128 352 WQSELENLEERLkALTGKHQDV------TAKYNRRRSKIKEQNnRDIAGIKDKLAKIREARDRQLAVAEDDLQALESELR 425
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1152 AESQRHSLRLEDRNQELVSECSHLRERL--CQYENE----KAEREVVVRQLQQELADTLKKQSMSEASLEVSSRYRSNLE 1225
Cdd:pfam12128 426 EQLEAGKLEFNEEEYRLKSRLGELKLRLnqATATPElllqLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQAS 505
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1226 EEARDLKKKLGQLRSQLQEARDQHREAVH--------HAEKMEDHLQKL---EL------------EKSKFEITIKKQSE 1282
Cdd:pfam12128 506 EALRQASRRLEERQSALDELELQLFPQAGtllhflrkEAPDWEQSIGKVispELlhrtdldpevwdGSVGGELNLYGVKL 585
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1283 EIDQLQENlSRVNLSEEDKEKLQKLTElkeslecTVDQEQKRSSALEKELAEFKEVLKMTKKELNE----YENRELNLRQ 1358
Cdd:pfam12128 586 DLKRIDVP-EWAASEEELRERLDKAEE-------ALQSAREKQAAAEEQLVQANGELEKASREETFartaLKNARLDLRR 657
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1359 diknnhlemdipvstlikkiddLTAKLETASSKClhlgkknqlLQQELLLMRTIQKKCGKLEKNKKQLEQEVVNLRSHME 1438
Cdd:pfam12128 658 ----------------------LFDEKQSEKDKK---------NKALAERKDSANERLNSLEAQLKQLDKKHQAWLEEQK 706
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1439 KNMVEHSQAQQYAREVEERARQDLVEKLKQVNLFLQAQAASQES-LEQLRENSNAS------VRSQMELRIKDLESQLYR 1511
Cdd:pfam12128 707 EQKREARTEKQAYWQVVEGALDAQLALLKAAIAARRSGAKAELKaLETWYKRDLASlgvdpdVIAKLKREIRTLERKIER 786
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124487433 1512 MKAqedfDKIELEKYKQLYQEEFRARK-SLSSKLNKTSEKLEEASSKLLLEEQQNRSLLSTLST 1574
Cdd:pfam12128 787 IAV----RRQEVLRYFDWYQETWLQRRpRLATQLSNIERAISELQQQLARLIADTKLRRAKLEM 846
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
59-210 |
1.31e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 66.24 E-value: 1.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 59 DVAKVQHILILGkSGVNDRDKKDRTALHLACAYG-HPEVVTLLVERKCEIDARDSESSTALIKAVQCQEEECAAILLDHG 137
Cdd:PHA02876 320 DTENIRTLIMLG-ADVNAADRLYITPLHQASTLDrNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYG 398
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124487433 138 ADPNVMDSSGNTALHYAVYSENTSMAAK-LLAHNANIEAKNKDDLTPMLLAVKEN-KQHIVEFLVKKKASIHAVD 210
Cdd:PHA02876 399 ADIEALSQKIGTALHFALCGTNPYMSVKtLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAIN 473
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
731-1566 |
5.09e-10 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 64.61 E-value: 5.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 731 KYKGLQKEMSETEEVKSRLehekvGWEQELCRLRFALKQEEEKRRSADQLSEKtsEQLRRKGEQCQSEVEARQQLEASLR 810
Cdd:pfam02463 171 KKEALKKLIEETENLAELI-----IDLEELKLQELKLKEQAKKALEYYQLKEK--LELEEEYLLYLDYLKLNEERIDLLQ 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 811 TLEMELKTVKSHLNQVLEERNETQRQLSREQNARMLQDGILASHLC-KQKEIEMTQKKMTSEVSVSHEKEKDLLHKNQRL 889
Cdd:pfam02463 244 ELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKlLAKEEEELKSELLKLERRKVDDEEKLKESEKEK 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 890 QDEVAVLRLEMDTIKSHNQEKEKRYLEDIKIANEKNDNLQRMVKL--NEETFTKTIFQYTGQLNSLKAENTMLSSKLDNE 967
Cdd:pfam02463 324 KKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLeqLEEELLAKKKLESERLSSAAKLKEEELELKSEE 403
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 968 KQNKERLetdvesfrSRLASALHDHAEIQTAKRDLEIAFQRARDEWFRVKDKMNFDMSNLRDNNEV-LSQQLSKTERKLN 1046
Cdd:pfam02463 404 EKEAQLL--------LELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLkDELELKKSEDLLK 475
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1047 SLEIEFHHTKDELREKTLALKHAQRDLSQTQCQMKEVEHMFQD-EQGKVSKFMGKQESIEERLAQLQSENTLLRQQLDDA 1125
Cdd:pfam02463 476 ETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDgVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSA 555
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1126 ANKAESKDKTIVNIQDQFQDVLTRFQAESqRHSLRLEDRNQELVSECSHLRERLCQYENEKAEREVVVRQLQQELADTLK 1205
Cdd:pfam02463 556 TADEVEERQKLVRALTELPLGARKLRLLI-PKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTEL 634
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1206 KQSMSEASLEVSSRYRSNLEEEARDLKKKLGQLRSQLQEARdqhreavhHAEKMEDHLQKLELEKSKFEITIKKQSEEID 1285
Cdd:pfam02463 635 TKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKEL--------LEIQELQEKAESELAKEEILRRQLEIKKKEQ 706
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1286 QLQENLSRVNLSEEDKEKLQKLTELKESLECTVDQEQKRSSALEKELAEF--KEVLKMTKKELNEYENRELNLRQDIKNN 1363
Cdd:pfam02463 707 REKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRlkKEEKEEEKSELSLKEKELAEEREKTEKL 786
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1364 HLEMDIpVSTLIKKIDDLTAKLETASSKCLHLGKKNQLLQQELLLMRTIQKKCGKLEKNKKQLEQEVVNLRSHMEKNMVE 1443
Cdd:pfam02463 787 KVEEEK-EEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITK 865
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1444 HSQAQQYAREVEERARQDLVEKLKQVNLFLQAQAASQESLEQL------RENSNASVRSQMELRIKDLESQLYRMKAQED 1517
Cdd:pfam02463 866 EELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKlnlleeKENEIEERIKEEAEILLKYEEEPEELLLEEA 945
|
810 820 830 840
....*....|....*....|....*....|....*....|....*....
gi 124487433 1518 FDKIELEKYKQlyQEEFRARKSLSSKLNKTSEKLEEASSKLLLEEQQNR 1566
Cdd:pfam02463 946 DEKEKEENNKE--EEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNK 992
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
43-190 |
1.52e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 62.59 E-value: 1.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 43 IHDKDMGK--IHKAASVGDvAKVQHILILGKSGVNDRDKKDRTALHLACAYGHPEVVTLLVERKCEIDARDSESSTALIK 120
Cdd:PHA02878 162 MKDRHKGNtaLHYATENKD-QRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHI 240
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124487433 121 AV-QCQEEECAAILLDHGADPNVMDS-SGNTALHYAVYSENTSMAakLLAHNANIEAKNKDDLTPMLLAVKE 190
Cdd:PHA02878 241 SVgYCKDYDILKLLLEHGVDVNAKSYiLGLTALHSSIKSERKLKL--LLEYGADINSLNSYKLTPLSSAVKQ 310
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
710-1536 |
1.69e-09 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 63.07 E-value: 1.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 710 LIELKRSHCELLTGKLKRMENKYKGLQKEMSETEEVKSRLEHEKVGWEQELCRLRFALKQEEEKRRSADQLSEKTSEQLR 789
Cdd:pfam02463 192 LEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVL 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 790 RKGEQCQSEVEARQQLEASLRTLEMELKTVKSHL-NQVLEERNETQRQLSREQNARMLQDGILASHLCKQKEIEMTQKKM 868
Cdd:pfam02463 272 KENKEEEKEKKLQEEELKLLAKEEEELKSELLKLeRRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKR 351
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 869 TSEVSVSHEKEKDLLHKNQRLQDEVAVLRLEMDTIKS----HNQEKEKRYlEDIKIANEKNDNLQRMVKLNEETFTKtif 944
Cdd:pfam02463 352 EAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSaaklKEEELELKS-EEEKEAQLLLELARQLEDLLKEEKKE--- 427
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 945 qytgqlnSLKAENTMLSSKLDNEKQNKERLETDVESFRSRLASALHDHAEIQTAKRDLEIAFQRARDEWFRVKDKMnFDM 1024
Cdd:pfam02463 428 -------ELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLE-ERS 499
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1025 SNLRDNNEVLSQQLSKTERKLNSLEIEFHHTKDELREKTLALKHA-----QRDLSQTQCQMKEVEHMFQ------DEQGK 1093
Cdd:pfam02463 500 QKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAistavIVEVSATADEVEERQKLVRaltelpLGARK 579
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1094 VSKFMGKQESIEERLAQLQSENTLLRQQLDDAANKAESKDKTIVNIQDQFQDVLtrfQAESQRHSLRLEDRNQELVSecs 1173
Cdd:pfam02463 580 LRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTE---LTKLKESAKAKESGLRKGVS--- 653
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1174 hlrerLCQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVSSRYRSNLEEEARDLKKKLGQLRSQLQEARDQHREAV 1253
Cdd:pfam02463 654 -----LEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQ 728
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1254 HHAEKMEDHLQKLELEKSKFEITIKKQSEEIDQLQENLSRVnLSEEDKEKLQKLTELKESLEctvDQEQKRSSALEKELA 1333
Cdd:pfam02463 729 EAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSEL-SLKEKELAEEREKTEKLKVE---EEKEEKLKAQEEELR 804
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1334 EFKEVLKMTKKELNEYENRELNL--RQDIKNNHLEMDIPVSTLIKKIDDLTAKLETASSKCLHLGKKNQLLQQELLLMRT 1411
Cdd:pfam02463 805 ALEEELKEEAELLEEEQLLIEQEekIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKL 884
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1412 IQKKCGKLEKNKKQLEQEVVNLRSHMEKNMVEHSQAQQYAREVEERaRQDLVEKLKQVNLFLQAQAASQESLEQLRENSN 1491
Cdd:pfam02463 885 KDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEIL-LKYEEEPEELLLEEADEKEKEENNKEEEEERNK 963
|
810 820 830 840
....*....|....*....|....*....|....*....|....*..
gi 124487433 1492 ASVRSQMELRIKDLES--QLYRMKAQEDFDKIELEKYKQLYQEEFRA 1536
Cdd:pfam02463 964 RLLLAKEELGKVNLMAieEFEEKEERYNKDELEKERLEEEKKKLIRA 1010
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
1162-1573 |
1.85e-09 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 62.77 E-value: 1.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1162 EDRNQELVSECSHLRERLCQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVSSRYRSNLEEEARDLKKklgqLRSQ 1241
Cdd:PRK03918 164 YKNLGEVIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEE----LKEE 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1242 LQEARDQhreavhhAEKMEDHLQKLELEKSKFEITIKKQSEEIDQLQENLSRVNLSEEDKEKLQKLTELKESLECTVDQE 1321
Cdd:PRK03918 240 IEELEKE-------LESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEEYLDELREI 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1322 QKRSSALEKELAEFKEVLK---MTKKELNEYENRELNLRQD---IKNNHLEMDiPVSTLIKKIDDLTAKLetassKCLHL 1395
Cdd:PRK03918 313 EKRLSRLEEEINGIEERIKeleEKEERLEELKKKLKELEKRleeLEERHELYE-EAKAKKEELERLKKRL-----TGLTP 386
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1396 GKKNQLLQQELLLMRTIQKKCGKLEKNKKQLEQEVVNLRSHMEKNMVEHSQAQQYAREVEERARQDLVEK-LKQVNLFLQ 1474
Cdd:PRK03918 387 EKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHRKELLEEyTAELKRIEK 466
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1475 AQAASQESLEQLREN-----------SNASVRSQMELRIKDLESQLyrmkaqEDFDKIELEKYKQLYQ---EEFRARKSL 1540
Cdd:PRK03918 467 ELKEIEEKERKLRKElrelekvlkkeSELIKLKELAEQLKELEEKL------KKYNLEELEKKAEEYEklkEKLIKLKGE 540
|
410 420 430
....*....|....*....|....*....|...
gi 124487433 1541 SSKLNKTSEKLEEASSKLLLEEQQNRSLLSTLS 1573
Cdd:PRK03918 541 IKSLKKELEKLEELKKKLAELEKKLDELEEELA 573
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
767-1553 |
2.03e-09 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 62.76 E-value: 2.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 767 LKQEEEKRRSADQLSEKTSEQLRRKGEQCQSEVEARQQLEASLRtlemelKTVKSHLNQvLEERNETQRQLSREQNARML 846
Cdd:TIGR00606 194 VRQTQGQKVQEHQMELKYLKQYKEKACEIRDQITSKEAQLESSR------EIVKSYENE-LDPLKNRLKEIEHNLSKIMK 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 847 QDGILASHLCKQKEIEMTQK----KMTSEVSVSHEKEKDLLHKNQRLQDEVAVLRLEMD-TIKSHNQEKEKRYLEDIKIA 921
Cdd:TIGR00606 267 LDNEIKALKSRKKQMEKDNSelelKMEKVFQGTDEQLNDLYHNHQRTVREKERELVDCQrELEKLNKERRLLNQEKTELL 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 922 NEkndnlQRMVKLNEETFTKTIFQYTG--QLNSLKAENTMLSSKLDNEKQNKERLETDVESFRSRLASALHDHAEIQtak 999
Cdd:TIGR00606 347 VE-----QGRLQLQADRHQEHIRARDSliQSLATRLELDGFERGPFSERQIKNFHTLVIERQEDEAKTAAQLCADLQ--- 418
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1000 rDLEIAFQRARDEwfrVKDKMNFDMSNLRDNNEVLSQQLSKTERKLNSLEiEFHHTKDELREKTLALKHAQRDLSQ---- 1075
Cdd:TIGR00606 419 -SKERLKQEQADE---IRDEKKGLGRTIELKKEILEKKQEELKFVIKELQ-QLEGSSDRILELDQELRKAERELSKaekn 493
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1076 --TQCQMKEVEHMfQDEQGKVSKfmgKQESIEERLAQLQSENTLLRQQLDDAANKAEsKDKTIVNIQDQFQDVLTRF--- 1150
Cdd:TIGR00606 494 slTETLKKEVKSL-QNEKADLDR---KLRKLDQEMEQLNHHTTTRTQMEMLTKDKMD-KDEQIRKIKSRHSDELTSLlgy 568
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1151 -----QAESQRHSLR-----LEDRNQELVSECSHLRERLCQYENEKAER--------------------EVVVRQLQQEL 1200
Cdd:TIGR00606 569 fpnkkQLEDWLHSKSkeinqTRDRLAKLNKELASLEQNKNHINNELESKeeqlssyedklfdvcgsqdeESDLERLKEEI 648
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1201 ADTLKKQSMSEASLEVSSRYRSNLEEEARD---LKKKLGQLRSQLQEA----RDQHREAVHHAEKMEDHLQKLELEKSKF 1273
Cdd:TIGR00606 649 EKSSKQRAMLAGATAVYSQFITQLTDENQSccpVCQRVFQTEAELQEFisdlQSKLRLAPDKLKSTESELKKKEKRRDEM 728
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1274 EITIKKQSEEIDQLQENLSRVnlseedKEKLQKLTELKESLECTVDQEQKRSSAL--EKELAE--FKEVLKMTKKELNEY 1349
Cdd:TIGR00606 729 LGLAPGRQSIIDLKEKEIPEL------RNKLQKVNRDIQRLKNDIEEQETLLGTImpEEESAKvcLTDVTIMERFQMELK 802
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1350 ENRELNLRQDIKNNHLEMDIPVSTLIKKIDDLTAKLETASSKCLHLGKknqLLQQELLLMRTIQKKCGKLEKNKKQLEQE 1429
Cdd:TIGR00606 803 DVERKIAQQAAKLQGSDLDRTVQQVNQEKQEKQHELDTVVSKIELNRK---LIQDQQEQIQHLKSKTNELKSEKLQIGTN 879
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1430 VVNLRSHMEKNMVEHSQAQQYAREVEERARQDLVEKLkqvnlFLQAQAASQESLEQLRENSNASVRSQMELRIKDLESQL 1509
Cdd:TIGR00606 880 LQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLET-----FLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIH 954
|
810 820 830 840
....*....|....*....|....*....|....*....|....
gi 124487433 1510 YRMKAQEDFDKIELEKYKQLYQEEFRARKSLSSKLNKTSEKLEE 1553
Cdd:TIGR00606 955 GYMKDIENKIQDGKDDYLKQKETELNTVNAQLEECEKHQEKINE 998
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
25-212 |
2.50e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 62.00 E-value: 2.50e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 25 CVGFGRESASGSHVPRYHIHDK-DMGKIHKAASVGDVAKVQHILILGKSGVNDRDKKDRTALHLACAYGHPEVVTLLVER 103
Cdd:PHA02876 121 CIHILKEAISGNDIHYDKINESiEYMKLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSY 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 104 ---------------KCEIDARDSESSTALI--------------KAVQCQEEECAAILLDHGADPNVMDSSGNTALHYA 154
Cdd:PHA02876 201 gadvniialddlsvlECAVDSKNIDTIKAIIdnrsninkndlsllKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHA 280
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 155 VYSENTS-MAAKLLAHNANIEAKNKDDLTPMLLAVKEN-KQHIVEFLVKKKASIHAVDQL 212
Cdd:PHA02876 281 SQAPSLSrLVPKLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRL 340
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
41-210 |
2.78e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 61.43 E-value: 2.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 41 YHIHDKDMGKIHKAASVGdvAKVQHILILGKSGVNDRDK-KDRTALHLACAYGHPEVVTLLVERKCEIDARDSESSTALI 119
Cdd:PHA02878 129 QTIDLVYIDKKSKDDIIE--AEITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLH 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 120 KAVQCQEEECAAILLDHGADPNVMDSSGNTALHYAV-YSENTSMAAKLLAHNANIEAKNK-DDLTPMLLAVKEnkQHIVE 197
Cdd:PHA02878 207 HAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVgYCKDYDILKLLLEHGVDVNAKSYiLGLTALHSSIKS--ERKLK 284
|
170
....*....|...
gi 124487433 198 FLVKKKASIHAVD 210
Cdd:PHA02878 285 LLLEYGADINSLN 297
|
|
| Mplasa_alph_rch |
TIGR04523 |
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
903-1553 |
2.90e-09 |
|
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.
Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 61.96 E-value: 2.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 903 IKSHNQEKEKRYLEDIKIANEKNDNLQRMVKLNEETFTK---TIFQYTGQLNSLKAENTMLSSKLDNEKQNKERLETDVe 979
Cdd:TIGR04523 27 IANKQDTEEKQLEKKLKTIKNELKNKEKELKNLDKNLNKdeeKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDL- 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 980 sfrSRLASALHDHAEIQTAKRDLEIAFQRARDEWFRVKDKMNFDMSNLRDNNEVLSQQLSKTERKLNSLEIEFHHTKDEL 1059
Cdd:TIGR04523 106 ---SKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEK 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1060 REKtlalkhaQRDLSQTQCQMKEVEHMFQDEQGKVSKfmgkQESIEERLAQLQSENTLLRQQLDDAANKAESKDKTIVNI 1139
Cdd:TIGR04523 183 LNI-------QKNIDKIKNKLLKLELLLSNLKKKIQK----NKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNT 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1140 QDQFQDVLTrfqaESQRHSLRLEDRNQELVSECSHLRERLCQYENEKAEREVVVRQLQQELADTLKkqsmseaslevssr 1219
Cdd:TIGR04523 252 QTQLNQLKD----EQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKELK-------------- 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1220 yrsnleEEARDLKKKLGQLRSQLQEARDQHREAVHHAEKMEDHLQKLELEKSKFEITIKKQSEEIDQLQENlsrvnlSEE 1299
Cdd:TIGR04523 314 ------SELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKE------NQS 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1300 DKEKLQKLTELKESLECTVDQEQKRSSALEKELAEFKEVLKMTKKELNEYENRELNLRQDIKNnhLEMDIPV-STLIKKI 1378
Cdd:TIGR04523 382 YKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKD--LTNQDSVkELIIKNL 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1379 DDLTAKLETASSKCLHLGKKNQLlqqelllmrtiqkkcgKLEKNKKQLEQEVVNLRSHMEKNmvehsqaqqyareveera 1458
Cdd:TIGR04523 460 DNTRESLETQLKVLSRSINKIKQ----------------NLEQKQKELKSKEKELKKLNEEK------------------ 505
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1459 rQDLVEKLKQVNlflQAQAASQESLEQLRensnaSVRSQMELRIKDLESQLYRMKaqEDFDKIELEKYKQLYQEEFRARK 1538
Cdd:TIGR04523 506 -KELEEKVKDLT---KKISSLKEKIEKLE-----SEKKEKESKISDLEDELNKDD--FELKKENLEKEIDEKNKEIEELK 574
|
650
....*....|....*
gi 124487433 1539 SLSSKLNKTSEKLEE 1553
Cdd:TIGR04523 575 QTQKSLKKKQEEKQE 589
|
|
| PRK02224 |
PRK02224 |
DNA double-strand break repair Rad50 ATPase; |
740-1319 |
6.47e-09 |
|
DNA double-strand break repair Rad50 ATPase;
Pssm-ID: 179385 [Multi-domain] Cd Length: 880 Bit Score: 60.82 E-value: 6.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 740 SETEEVKSRLEHEKV-GWEQELCRLRFALKQEEEKRRSADQLSEKTSEQLrrkgeqcqSEVEARQQleaslrtlemELKT 818
Cdd:PRK02224 194 AQIEEKEEKDLHERLnGLESELAELDEEIERYEEQREQARETRDEADEVL--------EEHEERRE----------ELET 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 819 VKSHLNQVLEERNETQRQlsREQNARmlqdgilashlckqkeiemtqkkmtsEVSVSHEKEKDLLHKNQRLQDEVAVLRL 898
Cdd:PRK02224 256 LEAEIEDLRETIAETERE--REELAE--------------------------EVRDLRERLEELEEERDDLLAEAGLDDA 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 899 EMDTIKSHNQEKEKRyledikiANEKNDNLQRmVKLNEETFTKTIFQYTGQLNSLKAENTmlsskldnEKQNK-ERLETD 977
Cdd:PRK02224 308 DAEAVEARREELEDR-------DEELRDRLEE-CRVAAQAHNEEAESLREDADDLEERAE--------ELREEaAELESE 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 978 VESFRSRLASALHDHAEIQTAKRDLEIAFQRARDewfrvkdkmnfDMSNLRDNNEVLSQQLSKTERKLNSLEIEFHHTKD 1057
Cdd:PRK02224 372 LEEAREAVEDRREEIEELEEEIEELRERFGDAPV-----------DLGNAEDFLEELREERDELREREAELEATLRTARE 440
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1058 ELREktlalkhAQRDLSQTQC-----QMKEVEHMFQDEQGKVskfmgKQESIEERLAQLQSENTLLRQQLDDA--ANKAE 1130
Cdd:PRK02224 441 RVEE-------AEALLEAGKCpecgqPVEGSPHVETIEEDRE-----RVEELEAELEDLEEEVEEVEERLERAedLVEAE 508
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1131 SKDKTIVNIQDQFQDVLTRFQAESQRHSLRLE---DRNQELVSECSHLRERLCQYENEKAEREVVVRQLQQELAdTLKKQ 1207
Cdd:PRK02224 509 DRIERLEERREDLEELIAERRETIEEKRERAEelrERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLA-ELKER 587
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1208 SMSEASLEVSSRYRSNLEEEARDLKKKLGQL-------RSQLQEARDQHREAvhHAEKMEDHLQKLELEKSKFEITIKKQ 1280
Cdd:PRK02224 588 IESLERIRTLLAAIADAEDEIERLREKREALaelnderRERLAEKRERKREL--EAEFDEARIEEAREDKERAEEYLEQV 665
|
570 580 590 600
....*....|....*....|....*....|....*....|...
gi 124487433 1281 SEEIDQLQEN----LSRVNLSEEDKEKLQKLTELKESLECTVD 1319
Cdd:PRK02224 666 EEKLDELREErddlQAEIGAVENELEELEELRERREALENRVE 708
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
51-214 |
7.85e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 60.28 E-value: 7.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 51 IHKAASVGDVAKVQHILILGKSgVNDRDKKDRTALHLACAY----GHPEVVTLLVERKCE-------------------- 106
Cdd:PHA02878 41 LHQAVEARNLDVVKSLLTRGHN-VNQPDHRDLTPLHIICKEpnklGMKEMIRSINKCSVFytlvaikdafnnrnveifki 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 107 --IDARDSESSTALIKAVQCQ-----EEECAAILLDHGADPNVMD-SSGNTALHYAVYSENTSMAAKLLAHNANIEAKNK 178
Cdd:PHA02878 120 ilTNRYKNIQTIDLVYIDKKSkddiiEAEITKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDK 199
|
170 180 190
....*....|....*....|....*....|....*.
gi 124487433 179 DDLTPMLLAVKENKQHIVEFLVKKKASIHAVDQLGS 214
Cdd:PHA02878 200 TNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGN 235
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
909-1356 |
8.57e-09 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 60.46 E-value: 8.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 909 EKEKRYLEDIKIANEkndNLQRMVKLNEETFTKTIfqytGQLNSLKAENTMLSSKLDNEKQNKERLEtdveSFRSRLASA 988
Cdd:PRK03918 175 KRRIERLEKFIKRTE---NIEELIKEKEKELEEVL----REINEISSELPELREELEKLEKEVKELE----ELKEEIEEL 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 989 LHDHAEIQTAKRDLEIAFQRARDEWFRVKDKMNFDMSNLRDNNEVlsQQLSKTERKLNSLEIEFhhtKDELREKTLALKH 1068
Cdd:PRK03918 244 EKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKEL--KEKAEEYIKLSEFYEEY---LDELREIEKRLSR 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1069 AQRDLSQTQCQMKEVEhmfqDEQGKVSKFMGKQESIEERLAQLQSENTLL---RQQLDDAAN-KAESKDKTIVNIQDQFQ 1144
Cdd:PRK03918 319 LEEEINGIEERIKELE----EKEERLEELKKKLKELEKRLEELEERHELYeeaKAKKEELERlKKRLTGLTPEKLEKELE 394
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1145 DvltrfqaesqrhslrLEDRNQELVSECSHLRERLCQYENEKAEREVVVRQLQ----------QELADTLKKQSMSEASL 1214
Cdd:PRK03918 395 E---------------LEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKkakgkcpvcgRELTEEHRKELLEEYTA 459
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1215 EVSsryrsNLEEEARDLKKKLGQLRSQLQEardqhreavhhaekmedhLQKLELEKSKFeITIKKQSEEIDQLQENLSRV 1294
Cdd:PRK03918 460 ELK-----RIEKELKEIEEKERKLRKELRE------------------LEKVLKKESEL-IKLKELAEQLKELEEKLKKY 515
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124487433 1295 NLS--EEDKEKLQKLTELKESLEC---TVDQEQKRSSALEKELAEFKEVLKMTKKELNEYENRELNL 1356
Cdd:PRK03918 516 NLEelEKKAEEYEKLKEKLIKLKGeikSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEEL 582
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
708-1312 |
8.71e-09 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 60.46 E-value: 8.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 708 KRLIELKRSHCELLTGKLKRMENKYKGLQKEMSETEEVKSRLEHEKVGWEQELCRLRFALKQEEEKRRSADQLSEKTSEQ 787
Cdd:PRK03918 171 IKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESL 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 788 LRRKGEqcqsevearqqLEASLRTLEMELKTVKSHLnQVLEERNETQRQLSREQNARMLQDGILASHLCKQKEIEMTQKK 867
Cdd:PRK03918 251 EGSKRK-----------LEEKIRELEERIEELKKEI-EELEEKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSR 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 868 MTSEVSVSHEKEKDLLHKNQRLQDevavlrlemdtIKSHNQEKEKRYLEdikianekndnLQRMVKLNEEtftktIFQYT 947
Cdd:PRK03918 319 LEEEINGIEERIKELEEKEERLEE-----------LKKKLKELEKRLEE-----------LEERHELYEE-----AKAKK 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 948 GQLNSLKAENTMLS-----SKLDNEKQNKERLETDVESFRSRLASALHDHAEIQTAKRDLEIAFQR--------ARDEWF 1014
Cdd:PRK03918 372 EELERLKKRLTGLTpekleKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKcpvcgrelTEEHRK 451
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1015 RVKDKMNFDMSNLRDNNEVLSQQLSKTERKLNSLEIEFHHTKDELREKTLA--LKHAQRDLSQTQCQ-MKEVEHMFQDEQ 1091
Cdd:PRK03918 452 ELLEEYTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKELAeqLKELEEKLKKYNLEeLEKKAEEYEKLK 531
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1092 GKVSKFMGKQESIE---ERLAQLQSENTLLRQQLDDAANKAESKDKTIVNIQ-DQFQDVLTRFQAESQRHSLRLEDRNQE 1167
Cdd:PRK03918 532 EKLIKLKGEIKSLKkelEKLEELKKKLAELEKKLDELEEELAELLKELEELGfESVEELEERLKELEPFYNEYLELKDAE 611
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1168 lvSECSHLRERLcqyenEKAEREVVvrQLQQELADTLKKQSMSEASLEVSSRYRSnlEEEARDLKKKLGQLRSQLQEARD 1247
Cdd:PRK03918 612 --KELEREEKEL-----KKLEEELD--KAFEELAETEKRLEELRKELEELEKKYS--EEEYEELREEYLELSRELAGLRA 680
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124487433 1248 QHREAVHHAEKMEDHLQKLELEKSKfeitIKKQSEEIDQLQENLSRVnlsEEDKEKLQKL-TELKE 1312
Cdd:PRK03918 681 ELEELEKRREEIKKTLEKLKEELEE----REKAKKELEKLEKALERV---EELREKVKKYkALLKE 739
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
756-1564 |
1.46e-08 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 60.06 E-value: 1.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 756 WEQELCRLRFALKQEEEKRRSADQLSEKTSEQLRRKGEQCQSEVEARQQLEASLRTLEMELKTVKSHLNQVLEERNETQR 835
Cdd:TIGR00606 243 YENELDPLKNRLKEIEHNLSKIMKLDNEIKALKSRKKQMEKDNSELELKMEKVFQGTDEQLNDLYHNHQRTVREKERELV 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 836 QLSREQNaRMLQDGILASHLCKQKEIEMTQKKMTSEVSVSHEKEKDLLHKNQRLQDEVAVLRLEMDT---IKSHNQEKEK 912
Cdd:TIGR00606 323 DCQRELE-KLNKERRLLNQEKTELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSerqIKNFHTLVIE 401
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 913 RYLEDIKIANEKNDNLQRMVKLNEETFTKTIFQYTGQLNSLKAENTMLSSKLDN-----------EKQNKERLETDVESF 981
Cdd:TIGR00606 402 RQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEElkfvikelqqlEGSSDRILELDQELR 481
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 982 RSRLASALHDHAEIQTAKRDLEIAFQRARDEWFRVKDKMNFDMSNLRDNNEVLSQQLSKTERK----------------- 1044
Cdd:TIGR00606 482 KAERELSKAEKNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTQMEMLTKDKmdkdeqirkiksrhsde 561
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1045 LNSLEIEFHHTK---DELREKTLALKHAQRDLSQTQCQMKEVEHMFQDEQGKVSKFMGKQESIEERLAQ------LQSEN 1115
Cdd:TIGR00606 562 LTSLLGYFPNKKqleDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDvcgsqdEESDL 641
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1116 TLLRQQLDDAAnKAESKDKTIVNIQDQFQDVLTRFQAESQRHSLRLEDRNQELVSECSHLRERLCQYENEKAEREVVVRQ 1195
Cdd:TIGR00606 642 ERLKEEIEKSS-KQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKK 720
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1196 LQQELADTLKKQSMSEASLEVSSRYRSNLEEEARDLKKKLGQLRSQLQEARDQHREAVHHAEKMEDHL------QKLELE 1269
Cdd:TIGR00606 721 KEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLtdvtimERFQME 800
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1270 KSKFEITIKKQSEEIDQLQENLSRVNLSEEDKEKLQKLTELKESLEctvdqeqkrssALEKELAEFKEVLKMTKKELNEY 1349
Cdd:TIGR00606 801 LKDVERKIAQQAAKLQGSDLDRTVQQVNQEKQEKQHELDTVVSKIE-----------LNRKLIQDQQEQIQHLKSKTNEL 869
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1350 ENRELNLRQDIKNNHlEMDIPVSTLIKKIDDLTAKLETASSKCLHLgkKNQLLQQELLLMRTIQKKcgklEKNKKQLEQE 1429
Cdd:TIGR00606 870 KSEKLQIGTNLQRRQ-QFEEQLVELSTEVQSLIREIKDAKEQDSPL--ETFLEKDQQEKEELISSK----ETSNKKAQDK 942
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1430 VVNLRSHMEKNMVEHSQAQQYAREVEERARQDLVEKLKQVNLFLQAQAASQESLEQLRENSNASVRSQmELRIKDLESQL 1509
Cdd:TIGR00606 943 VNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQKETELNTVNAQLEECEKHQEKINEDMRLMRQDIDTQ-KIQERWLQDNL 1021
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|....*...
gi 124487433 1510 YRMKAQEDFDKIELEK---YKQLYQEEFRARKSLSSKLNKTSEKLEEASSKLLLEEQQ 1564
Cdd:TIGR00606 1022 TLRKRENELKEVEEELkqhLKEMGQMQVLQMKQEHQKLEENIDLIKRNHVLALGRQKG 1079
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
83-207 |
1.57e-08 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 59.26 E-value: 1.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 83 TALHLACAYGHPEVVTLLVERKCE-IDARD-----SESSTALIK--------AVQCQEEECAAILLDHGADPNVMDSSGN 148
Cdd:cd22192 91 TALHIAVVNQNLNLVRELIARGADvVSPRAtgtffRPGPKNLIYygehplsfAACVGNEEIVRLLIEHGADIRAQDSLGN 170
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124487433 149 TALHYAVYSENTSMAAK----LLAHNANIEA------KNKDDLTPMLLAVKENKQHIVEFLVKKKASIH 207
Cdd:cd22192 171 TVLHILVLQPNKTFACQmydlILSYDKEDDLqpldlvPNNQGLTPFKLAAKEGNIVMFQHLVQKRRHIQ 239
|
|
| SCP-1 |
pfam05483 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
736-1363 |
1.83e-08 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 59.35 E-value: 1.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 736 QKEMSETEEVKSRLEHEKVGWEQELCRLRFALKQEEEKRRSADQLSEK--TSEQLRRKGEQCQSEVEARQQLE---ASLR 810
Cdd:pfam05483 103 QKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENnaTRHLCNLLKETCARSAEKTKKYEyerEETR 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 811 TLEMELKTVKSHLNQVLEERNETQRQLSREQNARMLQDGILASHLCK--QKEIEMTQKKMTSEVSVSHEKE---KDLLHK 885
Cdd:pfam05483 183 QVYMDLNNNIEKMILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEeyKKEINDKEKQVSLLLIQITEKEnkmKDLTFL 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 886 NQRLQDEVAVL----RLEMDTIKSHNQEKE--KRYLEDIKIANEKNDNLQRMVKLNEETFTKTIFQYTGQ---------- 949
Cdd:pfam05483 263 LEESRDKANQLeektKLQDENLKELIEKKDhlTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEkeaqmeelnk 342
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 950 --------LNSLKAENTMLSSKLDNEKQNKERLETDVESFRSRLASALHDHAEIQTAKRDLEIAFQrardewfRVKDKMN 1021
Cdd:pfam05483 343 akaahsfvVTEFEATTCSLEELLRTEQQRLEKNEDQLKIITMELQKKSSELEEMTKFKNNKEVELE-------ELKKILA 415
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1022 FDMSNLRDNNEV--LSQQLSKTERKLNSL----EIEFHHTKDELREKTLALKHAQRdlsqtqcQMKEVEHMFQDEQGKVS 1095
Cdd:pfam05483 416 EDEKLLDEKKQFekIAEELKGKEQELIFLlqarEKEIHDLEIQLTAIKTSEEHYLK-------EVEDLKTELEKEKLKNI 488
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1096 KFMGKQEsieerlaQLQSENTLLRQQLDDAANKAESKDKTIVNIQDQFQDVLTRFQA-ESQRHSLR--LEDRNQELVSEC 1172
Cdd:pfam05483 489 ELTAHCD-------KLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENlEEKEMNLRdeLESVREEFIQKG 561
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1173 SHLRERLCQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVSSRYRSNLEEEARDLKK--------------KLGQL 1238
Cdd:pfam05483 562 DEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKkgsaenkqlnayeiKVNKL 641
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1239 RSQLQEARDQHREAVHHAEK--------MEDHLQKLELEKSKFEITIKKQSEEIDQLQENLSR-VNLSEEDKEKLQKLTE 1309
Cdd:pfam05483 642 ELELASAKQKFEEIIDNYQKeiedkkisEEKLLEEVEKAKAIADEAVKLQKEIDKRCQHKIAEmVALMEKHKHQYDKIIE 721
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*...
gi 124487433 1310 LKES-LECTVDQEQKRSS---ALEKELAEFKEVLKMTKKELNEYENRELNLRQDIKNN 1363
Cdd:pfam05483 722 ERDSeLGLYKNKEQEQSSakaALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKEN 779
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
115-167 |
2.01e-08 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 51.89 E-value: 2.01e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 124487433 115 STALIKAVQCQEEECAAILLDHGADPNVMDSSGNTALHYAVYSENTSMAAKLL 167
Cdd:pfam13637 2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| SCP-1 |
pfam05483 |
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ... |
902-1568 |
7.75e-08 |
|
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.
Pssm-ID: 114219 [Multi-domain] Cd Length: 787 Bit Score: 57.42 E-value: 7.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 902 TIKSHNQEKEKRYLEDIKIANEKNDNLQRMVKLNEETFTKTIFQYTGQLNSLKAENT------MLSSKLDNEKQNKERLE 975
Cdd:pfam05483 96 SIEAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNAtrhlcnLLKETCARSAEKTKKYE 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 976 TDVESFRSRLASALHDHAEIQTAKRDLEIAFQRARDEW-FRVKDkmnfDMSNLRDNNEVLSQQLSKTERKLNSLEIEFHH 1054
Cdd:pfam05483 176 YEREETRQVYMDLNNNIEKMILAFEELRVQAENARLEMhFKLKE----DHEKIQHLEEEYKKEINDKEKQVSLLLIQITE 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1055 TKDELREKTLALKHAQRDLSQTQCQMKEVEHMFQDEQGKVSKFMGKQESIEERLAQLQSENTLLRQQLDDAAnkaeskdK 1134
Cdd:pfam05483 252 KENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIAT-------K 324
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1135 TIVNIQDQFQDVLTRFQAESQRHSLRLEDRNQELVSECSHLRERLCQYENEKAEREVVVRQLQQEladtlkkqsmsEASL 1214
Cdd:pfam05483 325 TICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEKNEDQLKIITMELQKK-----------SSEL 393
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1215 EVSSRYRSNLEEEARDLKKKLGQLRSQL----------QEARDQHREAVHHAEKMEDHLQKLELEKSKFEITIKKQSEEI 1284
Cdd:pfam05483 394 EEMTKFKNNKEVELEELKKILAEDEKLLdekkqfekiaEELKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEV 473
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1285 DQLQENLsrvnlsEEDKEKLQKLTELKESLECTVDQEQKRSSALEKELAEFKEVLKMTKKELNEYENRELNLRQDIKNNH 1364
Cdd:pfam05483 474 EDLKTEL------EKEKLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLR 547
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1365 LEMDIPVSTLIKKIDDLTAKL----ETASSKCLHLGKKNQLLQQELLLMRTIQKKCGKLEKNKKQLEQEVVNLRshmEKN 1440
Cdd:pfam05483 548 DELESVREEFIQKGDEVKCKLdkseENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALK---KKG 624
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1441 MVEHSQAQQYAREVE------ERARQDLVEKLKQVNLFLQAQAASQESL----EQLRENSNASVRSQMEL------RIKD 1504
Cdd:pfam05483 625 SAENKQLNAYEIKVNklelelASAKQKFEEIIDNYQKEIEDKKISEEKLleevEKAKAIADEAVKLQKEIdkrcqhKIAE 704
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1505 LESQLYRMKAQedFDKI------ELEKYKQLYQEEFRARKSLSSKLNKTSEKLEEASSKLLLEEQQNRSL 1568
Cdd:pfam05483 705 MVALMEKHKHQ--YDKIieerdsELGLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKL 772
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
1002-1388 |
8.15e-08 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 57.08 E-value: 8.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1002 LEIAFQRARDEWFRVKDKmnfdmsnlrdNNEVLSQQLSKTERKLNSLEIEfhhtKDELREKTLALKHAQRDLSQTQCQMK 1081
Cdd:COG4717 47 LLERLEKEADELFKPQGR----------KPELNLKELKELEEELKEAEEK----EEEYAELQEELEELEEELEELEAELE 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1082 EVEHMFQ--DEQGKVSKFMGKQESIEERLAQLQSENTLLRQQLD---DAANKAESKDKTIVNIQDQFQDVLTRFQAESQR 1156
Cdd:COG4717 113 ELREELEklEKLLQLLPLYQELEALEAELAELPERLEELEERLEelrELEEELEELEAELAELQEELEELLEQLSLATEE 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1157 HSLRLEDRNQELVSECSHLRERLCQYENEKAEREVVVRQLQQELADTLKKQSMSEAS----------------------- 1213
Cdd:COG4717 193 ELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARlllliaaallallglggsllsli 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1214 ---------------LEVSSRYRSNLEEEARDLKKKLGQLRSQLQEAR--------------------------DQHREA 1252
Cdd:COG4717 273 ltiagvlflvlgllaLLFLLLAREKASLGKEAEELQALPALEELEEEEleellaalglppdlspeellelldriEELQEL 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1253 VHHAEKMEDHLQKLELEKSKFEITIKKQSEEIDQLQENLSRVNLSEEDKEKLQKLTELKESLECTVDQEQKRSS--ALEK 1330
Cdd:COG4717 353 LREAEELEEELQLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALDeeELEE 432
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 124487433 1331 ELAEFKEVLKMTKKELNEYENRELNLRQDIKnnHLEMDIPVSTLIKKIDDLTAKLETA 1388
Cdd:COG4717 433 ELEELEEELEELEEELEELREELAELEAELE--QLEEDGELAELLQELEELKAELREL 488
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
820-1466 |
1.13e-07 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 57.05 E-value: 1.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 820 KSHLNQVLEERN----ETQRQLSREQNARMLQDGILASHL----CKQKEIEMTQKKMTSEVSVSHEKEKDLLHKNQRLQD 891
Cdd:pfam15921 73 KEHIERVLEEYShqvkDLQRRLNESNELHEKQKFYLRQSVidlqTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVH 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 892 EVAVLR-LEMDTIKSHNQEKEK----------------RYLEDIKIANEK----NDNLQRM---------VKLNEETFTK 941
Cdd:pfam15921 153 ELEAAKcLKEDMLEDSNTQIEQlrkmmlshegvlqeirSILVDFEEASGKkiyeHDSMSTMhfrslgsaiSKILRELDTE 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 942 T------IFQYTGQLNSLKAENT-----MLSSKLDNEKQNKERLETDVESFRSRLASALHDHAEIQTakrDLEIAFQRAR 1010
Cdd:pfam15921 233 IsylkgrIFPVEDQLEALKSESQnkielLLQQHQDRIEQLISEHEVEITGLTEKASSARSQANSIQS---QLEIIQEQAR 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1011 DE---WFRVKDKMNFDMSNLR-----------DNNEVLSQQL---------SKTER------------KLNSLEIEFHHT 1055
Cdd:pfam15921 310 NQnsmYMRQLSDLESTVSQLRselreakrmyeDKIEELEKQLvlanselteARTERdqfsqesgnlddQLQKLLADLHKR 389
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1056 KDELR-EK-------------TLALKHAQRDLSQTQCQMKEVEHMFQ----DEQGKVSKFM----GKQESIEE---RLAQ 1110
Cdd:pfam15921 390 EKELSlEKeqnkrlwdrdtgnSITIDHLRRELDDRNMEVQRLEALLKamksECQGQMERQMaaiqGKNESLEKvssLTAQ 469
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1111 LQSENTLLRQQLDDAANKA---ESKDKTIVNIQDQFQDVLTRFQAES-------QRHSLRLEDRnQELVSECSHLRERLC 1180
Cdd:pfam15921 470 LESTKEMLRKVVEELTAKKmtlESSERTVSDLTASLQEKERAIEATNaeitklrSRVDLKLQEL-QHLKNEGDHLRNVQT 548
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1181 QYENEK---AEREVVVRQLQQELADTLKKQSMseaslevSSRYRSNLEEEARDLKKKLGQLRSQLQEARDQHREAVHHAE 1257
Cdd:pfam15921 549 ECEALKlqmAEKDKVIEILRQQIENMTQLVGQ-------HGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIR 621
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1258 KMEDHLQKLELEKSKFeitIKKQSEEIDQLQE-NLSRVNLSEEDKEKLQKLTELKESLECTVDQEQKRSSALEKELAEFK 1336
Cdd:pfam15921 622 ELEARVSDLELEKVKL---VNAGSERLRAVKDiKQERDQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLK 698
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1337 EVLKMTKKELNEYENRELNLRQdiKNNH-----LEMDIPVSTLIKKIDDLTAKLE------TASSKCLHLGK--KNQLLQ 1403
Cdd:pfam15921 699 MQLKSAQSELEQTRNTLKSMEG--SDGHamkvaMGMQKQITAKRGQIDALQSKIQfleeamTNANKEKHFLKeeKNKLSQ 776
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124487433 1404 QELLLMRTIQKKCGKLE---KNKKQLEQEVVNLRSHMEKNMVEHSQAQQ-YAREVEERARQDLVEKL 1466
Cdd:pfam15921 777 ELSTVATEKNKMAGELEvlrSQERRLKEKVANMEVALDKASLQFAECQDiIQRQEQESVRLKLQHTL 843
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
74-121 |
1.50e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 49.65 E-value: 1.50e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 124487433 74 VNDRDKKDRTALHLACAYGHPEVVTLLVERKCEIDARDSESSTALIKA 121
Cdd:pfam13857 9 LNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
1163-1391 |
1.56e-07 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 55.54 E-value: 1.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1163 DRNQELVSECSHLRERLCQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVSSRYRSNLEEEARDLKKKLGQLRSQL 1242
Cdd:COG4942 20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1243 QEARDQHREAVHHAEKMEDHLQKLELEKSK-----------FEITIKKQSEEIDQLQENLsrvnlsEEDKEKLQKLTELK 1311
Cdd:COG4942 100 EAQKEELAELLRALYRLGRQPPLALLLSPEdfldavrrlqyLKYLAPARREQAEELRADL------AELAALRAELEAER 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1312 ESLECTVDQEQKRSSALEKELAEFKEVLKMTKKELNEYENRELNLRQDIKNnhlemdipvstLIKKIDDLTAKLETASSK 1391
Cdd:COG4942 174 AELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEE-----------LEALIARLEAEAAAAAER 242
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
651-1244 |
1.66e-07 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 56.48 E-value: 1.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 651 AAVDNLDDFTESSETASEDHELQGPDSESILCAIEHLRleckdtASLLKIRDAVYSYKRLIELKRSHCELLTGKLKRMEN 730
Cdd:COG1196 229 LLLLKLRELEAELEELEAELEELEAELEELEAELAELE------AELEELRLELEELELELEEAQAEEYELLAELARLEQ 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 731 KYKGLQKEMSETEEVKSRLEHEKVGWEQELCRLRFALKQEEEKRRSADQLSEKTSEQLRRKGEQCQSEVEARQQLEASLR 810
Cdd:COG1196 303 DIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELE 382
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 811 TLEMELKTVKSHLNQVLEERNETQRQLSREQNARmlqdgilASHLCKQKEIEMTQKKMTSEVSVSHEKEKDLLHKNQRLQ 890
Cdd:COG1196 383 ELAEELLEALRAAAELAAQLEELEEAEEALLERL-------ERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELE 455
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 891 DEVAVLRLEMDTIKSHNQEKEKRYLEDIKIANEKN---DNLQRMVKLNEEtftktiFQYTGQLNSLKAENTMLSSKLDNE 967
Cdd:COG1196 456 EEEEALLELLAELLEEAALLEAALAELLEELAEAAarlLLLLEAEADYEG------FLEGVKAALLLAGLRGLAGAVAVL 529
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 968 KQNKERLETDVESFRSRLASALHDHAEIQTAKRDLEIAFQRARDEWFRVKDKMNfdmsNLRDNNEVLSQQLSKTERKLNS 1047
Cdd:COG1196 530 IGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIR----ARAALAAALARGAIGAAVDLVA 605
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1048 LEIEFHHTKDELREKTLALK-HAQRDLSQTQCQMKEVEHMFQDEQGKVSKFMGKQESIEERLAQLQSENTLLRQQLDDAA 1126
Cdd:COG1196 606 SDLREADARYYVLGDTLLGRtLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELA 685
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1127 NKAEskdktivniqdqfqdvltrfQAESQRHSLRLEDRNQELvsecsHLRERLCQYENEKAEREVVVRQLQQELADTLKK 1206
Cdd:COG1196 686 ERLA--------------------EEELELEEALLAEEEEER-----ELAEAEEERLEEELEEEALEEQLEAEREELLEE 740
|
570 580 590
....*....|....*....|....*....|....*...
gi 124487433 1207 QSMSEASLEVSSRYRSNLEEEARDLKKKLGQLRSQLQE 1244
Cdd:COG1196 741 LLEEEELLEEEALEELPEPPDLEELERELERLEREIEA 778
|
|
| rad50 |
TIGR00606 |
rad50; All proteins in this family for which functions are known are involvedin recombination, ... |
729-1368 |
2.10e-07 |
|
rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).
Pssm-ID: 129694 [Multi-domain] Cd Length: 1311 Bit Score: 56.21 E-value: 2.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 729 ENKYKGLQKEMSETEEVKSRLEHEKVGWEQELCRLRFALKQEEEKRRSADQLSEKTSEQLRRKG--EQCQSEVEARQQLE 806
Cdd:TIGR00606 318 ERELVDCQRELEKLNKERRLLNQEKTELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGfeRGPFSERQIKNFHT 397
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 807 ASLRTLEMELKTVKSHLNQVLEERNETQRQLSREQNARMLQDGILASHLCKQKEIEMTQKKMTSEVSVSHEKEKDLLHKN 886
Cdd:TIGR00606 398 LVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILELD 477
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 887 QRLQDEVAVLRLEMDTIKSHNQEKEKRYLEDIK--IANEKNDNLQRMVKLNEETFTKTI-------------------FQ 945
Cdd:TIGR00606 478 QELRKAERELSKAEKNSLTETLKKEVKSLQNEKadLDRKLRKLDQEMEQLNHHTTTRTQmemltkdkmdkdeqirkikSR 557
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 946 YTGQLNSLKAE---NTMLSSKLDNEKQNKERLETDVESFRSRLASALHDHAEIQTAKRDLEIAFQRARDEWFRVKDKMNF 1022
Cdd:TIGR00606 558 HSDELTSLLGYfpnKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDVCGSQDE 637
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1023 --DMSNLRDNNEVLSQQLSKTERKLNSLEIEFHHTKDelrEKTLALKHAQRDLsQTQcqmKEVEHMFQDEQGKVSKFMGK 1100
Cdd:TIGR00606 638 esDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTD---ENQSCCPVCQRVF-QTE---AELQEFISDLQSKLRLAPDK 710
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1101 QESIEERLAQLQSENTLLRQQLDDAANKAESKDKTIVNIQDQFQDVLTRFQ--------AESQRHSLRLEDRNQELVSEC 1172
Cdd:TIGR00606 711 LKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQrlkndieeQETLLGTIMPEEESAKVCLTD 790
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1173 SHLRERLcQYENEKAEREV--------------VVRQLQQELADTLKKQSMSEASLEVSSRYRSNLEEEARDLKKKLGQL 1238
Cdd:TIGR00606 791 VTIMERF-QMELKDVERKIaqqaaklqgsdldrTVQQVNQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNEL 869
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1239 RSQlqeaRDQHREAVHHAEKMEDHLQKLELEKSKFEITIKKQSEEI--------DQLQENLSRVNLSEEDKEKLQ-KLTE 1309
Cdd:TIGR00606 870 KSE----KLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDspletfleKDQQEKEELISSKETSNKKAQdKVND 945
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 124487433 1310 LKESlectVDQEQKRSSALEKELAEFKEVLKMTKK--------ELNEYENRELNLRQDIKNNHLEMD 1368
Cdd:TIGR00606 946 IKEK----VKNIHGYMKDIENKIQDGKDDYLKQKEtelntvnaQLEECEKHQEKINEDMRLMRQDID 1008
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
1102-1574 |
2.92e-07 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 55.57 E-value: 2.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1102 ESIEERLAQLQSENTLLRQQLDDAANKAESKDKTIVNIQdqfqdvLTRFQAESQRHSLR-----LEDRNQELVSECSHLR 1176
Cdd:pfam01576 85 EEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQKLQ------LEKVTTEAKIKKLEedillLEDQNSKLSKERKLLE 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1177 ERLCQYENEKAEREVVVRQLQQ----------ELADTLKKQSMSEASLEVSSRyrsNLEEEARDLKKKLGQLRSQLQEAR 1246
Cdd:pfam01576 159 ERISEFTSNLAEEEEKAKSLSKlknkheamisDLEERLKKEEKGRQELEKAKR---KLEGESTDLQEQIAELQAQIAELR 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1247 DQHREavhHAEKMEDHLQKLELEKSKFEITIKKQSE---EIDQLQENLSRVNLSEEDKEKLQK---------LTELKESL 1314
Cdd:pfam01576 236 AQLAK---KEEELQAALARLEEETAQKNNALKKIREleaQISELQEDLESERAARNKAEKQRRdlgeelealKTELEDTL 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1315 ECTVDQEQKRSSAlEKELAEFKEVLKmtkKELNEYENRELNLRQdiKNNhlemdipvstliKKIDDLTAKLETASSKCLH 1394
Cdd:pfam01576 313 DTTAAQQELRSKR-EQEVTELKKALE---EETRSHEAQLQEMRQ--KHT------------QALEELTEQLEQAKRNKAN 374
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1395 LGKKN----QLLQQELLLMRTIQKKCGKLEKNKKQLEQEVVNLrshmeknMVEHSQAqqyareveERARQDLVEKLKQVN 1470
Cdd:pfam01576 375 LEKAKqaleSENAELQAELRTLQQAKQDSEHKRKKLEGQLQEL-------QARLSES--------ERQRAELAEKLSKLQ 439
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1471 LFLQAQAASQESLEqlrensNASVRSQMELriKDLESQLYrmKAQEdfdkielekykqLYQEEFRARKSLSSKLNKTSEK 1550
Cdd:pfam01576 440 SELESVSSLLNEAE------GKNIKLSKDV--SSLESQLQ--DTQE------------LLQEETRQKLNLSTRLRQLEDE 497
|
490 500
....*....|....*....|....
gi 124487433 1551 LEEASSKLLLEEQQNRSLLSTLST 1574
Cdd:pfam01576 498 RNSLQEQLEEEEEAKRNVERQLST 521
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
732-1365 |
3.68e-07 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 55.31 E-value: 3.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 732 YKGLQKEMSETEEVKSRLEhekvgweqELCRLRFALKQEEEKRRSADQLSEK-TSEQLRRKGEQCQSEVEarqQLEASLR 810
Cdd:COG4913 237 LERAHEALEDAREQIELLE--------PIRELAERYAAARERLAELEYLRAAlRLWFAQRRLELLEAELE---ELRAELA 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 811 TLEMELKTVKSHLNQVLEERNETQRQLSReqnarmlQDGILASHLckQKEIEMTQkkmtsevsvshEKEKDLLHKNQRLQ 890
Cdd:COG4913 306 RLEAELERLEARLDALREELDELEAQIRG-------NGGDRLEQL--EREIERLE-----------RELEERERRRARLE 365
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 891 DEVAVLRLEMDTIkshnqekEKRYLEDIKIANEKNDNLQRMVKLNEETFTKTIfqytGQLNSLKAENTMLSSKLDNEKQN 970
Cdd:COG4913 366 ALLAALGLPLPAS-------AEEFAALRAEAAALLEALEEELEALEEALAEAE----AALRDLRRELRELEAEIASLERR 434
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 971 KERLETDVESFRSRLASAL-----------------HDHAEIQTA--------KRDL---EIAFQRARdEWF-RVKDKMN 1021
Cdd:COG4913 435 KSNIPARLLALRDALAEALgldeaelpfvgelievrPEEERWRGAiervlggfALTLlvpPEHYAAAL-RWVnRLHLRGR 513
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1022 FDMSNLRDNNEvlSQQLSKTE-----RKLNSLEIEFHHT-KDELREKTL--------ALKHAQRDLSQTqCQMKEVEHMF 1087
Cdd:COG4913 514 LVYERVRTGLP--DPERPRLDpdslaGKLDFKPHPFRAWlEAELGRRFDyvcvdspeELRRHPRAITRA-GQVKGNGTRH 590
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1088 Q-DEQGKVSK--FMGkqESIEERLAQLQSENTLLRQQLDDAANKAESkdktivnIQDQFQDVLTRFQAESQRHSLRLEDR 1164
Cdd:COG4913 591 EkDDRRRIRSryVLG--FDNRAKLAALEAELAELEEELAEAEERLEA-------LEAELDALQERREALQRLAEYSWDEI 661
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1165 N-QELVSECSHLRERLCQYENEKAErevvVRQLQQELaDTLKKQsmseaslevssryRSNLEEEARDLKKKLGQLRSQLQ 1243
Cdd:COG4913 662 DvASAEREIAELEAELERLDASSDD----LAALEEQL-EELEAE-------------LEELEEELDELKGEIGRLEKELE 723
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1244 EARDQHREA---VHHAEKMEDHLQKLELEKsKFEITIKKQSEeiDQLQENLSrvnlseedkEKLQKLTELKESLEctvdq 1320
Cdd:COG4913 724 QAEEELDELqdrLEAAEDLARLELRALLEE-RFAAALGDAVE--RELRENLE---------ERIDALRARLNRAE----- 786
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|..
gi 124487433 1321 eqkrsSALEKELAEFKEVLKMTKKEL-------NEYenreLNLRQDIKNNHL 1365
Cdd:COG4913 787 -----EELERAMRAFNREWPAETADLdadleslPEY----LALLDRLEEDGL 829
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
151-202 |
8.03e-07 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 48.57 E-value: 8.03e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 124487433 151 LHYAVYSENTSMAAKLLAHNANIEAKNKDDLTPMLLAVKENKQHIVEFLVKK 202
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH 52
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
130-224 |
9.53e-07 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 53.75 E-value: 9.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 130 AAILLDHGADPNVMDSSGNTALHYAVYSENTSMAAKLLAHNANIEAKNKDDLTPMLLAVKENKQHIVEFLVKKKASIHav 209
Cdd:PTZ00322 98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHF-- 175
|
90
....*....|....*
gi 124487433 210 dQLGSNRQMFEYDGK 224
Cdd:PTZ00322 176 -ELGANAKPDSFTGK 189
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
723-1462 |
1.22e-06 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 53.61 E-value: 1.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 723 GKLKRMENKYKGLQKEMSETEEVKSRLEH----EKVGWEQELCRLRFALKQEEEKRRSADQLSEKTSE-QLRRKGEQCQS 797
Cdd:PTZ00121 1098 GKAEEAKKTETGKAEEARKAEEAKKKAEDarkaEEARKAEDARKAEEARKAEDAKRVEIARKAEDARKaEEARKAEDAKK 1177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 798 EVEARQQLEasLRTLEmELKTVKSHLNQVLEERNETQRqlsREQNARMLQDGILASHLCKQKEIemtqkKMTSEVSVSHE 877
Cdd:PTZ00121 1178 AEAARKAEE--VRKAE-ELRKAEDARKAEAARKAEEER---KAEEARKAEDAKKAEAVKKAEEA-----KKDAEEAKKAE 1246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 878 KEKDLLHKNQRLQDEVAVLRLEMDTIKShnqeKEKRYLEDIKIANE--KNDNLQRMVKLNEETFTKTIFQYTGQLNSLKA 955
Cdd:PTZ00121 1247 EERNNEEIRKFEEARMAHFARRQAAIKA----EEARKADELKKAEEkkKADEAKKAEEKKKADEAKKKAEEAKKADEAKK 1322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 956 ENTMLSSKLDNEKQNKERLETDVESFRsrlasalhdhAEIQTAKRDLEIAFQRAR-DEWFRVKDKMNFDMSNLRDNNEVL 1034
Cdd:PTZ00121 1323 KAEEAKKKADAAKKKAEEAKKAAEAAK----------AEAEAAADEAEAAEEKAEaAEKKKEEAKKKADAAKKKAEEKKK 1392
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1035 SQQLSKTERklnsleiEFHHTKDELREKTLALKHAQrDLSQTQCQMKEVEHMFQDEQGKVSKFMGKQESIEERLAQLQSE 1114
Cdd:PTZ00121 1393 ADEAKKKAE-------EDKKKADELKKAAAAKKKAD-EAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKK 1464
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1115 NTLLRQQLDDAANKAESKDKTivniqdqfqDVLTRFQAESQRHS--LRLEDRNQELVSECSHLRERLCQYENEKAEREVV 1192
Cdd:PTZ00121 1465 KAEEAKKADEAKKKAEEAKKA---------DEAKKKAEEAKKKAdeAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKK 1535
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1193 VRQLQQ----ELADTLKKQSMSEASLEVSSRYRSNLEEEARDLKKKLGQLRSQLQEARDQHREAVHHAEKMEDHLQKLEL 1268
Cdd:PTZ00121 1536 ADEAKKaeekKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKA 1615
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1269 EKSKFEITIKKQSEEIDQLQENLSRVnlSEEDKEKLQKLTELKESLECTVDQEQKRSSALEKELAEFK--EVLKMTKKEL 1346
Cdd:PTZ00121 1616 EEAKIKAEELKKAEEEKKKVEQLKKK--EAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKkaEEDEKKAAEA 1693
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1347 NEYENRELNLRQDIKNNHLEMdipvstlIKKIDDLTAKLETASSKCLHLGKKNQLLQQELLLMRTIQKKCGKLEKNKKQL 1426
Cdd:PTZ00121 1694 LKKEAEEAKKAEELKKKEAEE-------KKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEE 1766
|
730 740 750
....*....|....*....|....*....|....*..
gi 124487433 1427 EQEVVNLRSHMEKNMVEHSQAQQYAREVE-ERARQDL 1462
Cdd:PTZ00121 1767 EKKAEEIRKEKEAVIEEELDEEDEKRRMEvDKKIKDI 1803
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
969-1567 |
1.35e-06 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 53.53 E-value: 1.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 969 QNKERLETDVESFRSRLASALHDHAEIQTAKRDLEIAFQRARDEWFRVkDKMNFDMSNLRDNNEVLSQQLSKTERKLNSL 1048
Cdd:PRK03918 186 KRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKEL-EELKEEIEELEKELESLEGSKRKLEEKIREL 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1049 EIEFHHTKDELREktlaLKHAQRDLSQtqcqMKEVEHMFQDEQGKVSKFMGKQESIEERLAQLQSENTLLRQQLDDAank 1128
Cdd:PRK03918 265 EERIEELKKEIEE----LEEKVKELKE----LKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKEL--- 333
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1129 aESKDKTIVNIQDQFQDVLTRFQAESQRHslRLEDRNQELVSECSHLRERLCQYENEKAEREVvvrqlqqELADTLKKQS 1208
Cdd:PRK03918 334 -EEKEERLEELKKKLKELEKRLEELEERH--ELYEEAKAKKEELERLKKRLTGLTPEKLEKEL-------EELEKAKEEI 403
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1209 MSEASlEVSSRyRSNLEEEARDLKKKLGQLRSQLQEARDQHREAVHHAEKmeDHLQKLELEKSKFEITIKKQSEEIDQLQ 1288
Cdd:PRK03918 404 EEEIS-KITAR-IGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHRK--ELLEEYTAELKRIEKELKEIEEKERKLR 479
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1289 ENLSRVNLSEEDKEKLQKLTELKESLEctvdqeqkrssALEKELAEF-KEVLKMTKKELNEYENRELNLRQDIKNnhLEM 1367
Cdd:PRK03918 480 KELRELEKVLKKESELIKLKELAEQLK-----------ELEEKLKKYnLEELEKKAEEYEKLKEKLIKLKGEIKS--LKK 546
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1368 DIpvstliKKIDDLTAKLetasskclhlgkknqllqqelllmRTIQKKCGKLEKNKKQLEQEVVNLRSHMEKNMVEHsqa 1447
Cdd:PRK03918 547 EL------EKLEELKKKL------------------------AELEKKLDELEEELAELLKELEELGFESVEELEER--- 593
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1448 qqyAREVEERARQDLveKLKQVNLFLQAQAASQESLEQLRENSNASVrSQMELRIKDLESQLYRMKAQedFDKIELEKYK 1527
Cdd:PRK03918 594 ---LKELEPFYNEYL--ELKDAEKELEREEKELKKLEEELDKAFEEL-AETEKRLEELRKELEELEKK--YSEEEYEELR 665
|
570 580 590 600
....*....|....*....|....*....|....*....|..
gi 124487433 1528 QLYQEEFRARKSLSSKLNKTSEKLEEASSKL--LLEEQQNRS 1567
Cdd:PRK03918 666 EEYLELSRELAGLRAELEELEKRREEIKKTLekLKEELEERE 707
|
|
| CCDC158 |
pfam15921 |
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ... |
972-1552 |
1.53e-06 |
|
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain] Cd Length: 1112 Bit Score: 53.20 E-value: 1.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 972 ERLETDVESFRSRLASALHDHAEIQTAKRDLEIAFQRARDEWFRVKDKMNFDMSNLRDNNEVLSQQLSKTerkLNSLEIE 1051
Cdd:pfam15921 81 EEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNT---VHELEAA 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1052 FHHTKDELREKTLALKHAQRDLSQTQCQMKEVEHMFQDEQGKVSKFMGKQESIEErlAQLQSENTLLRQQLDDAANKAES 1131
Cdd:pfam15921 158 KCLKEDMLEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASGKKIYEHDSMST--MHFRSLGSAISKILRELDTEISY 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1132 KDKTIVNIQDQFQDVLTRFQAESQRHSLRLEDRNQELVSE----CSHLRERLC----QYENEKAEREVVVRQLQQELADT 1203
Cdd:pfam15921 236 LKGRIFPVEDQLEALKSESQNKIELLLQQHQDRIEQLISEheveITGLTEKASsarsQANSIQSQLEIIQEQARNQNSMY 315
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1204 LKKQSMSEASLevsSRYRSNLEEEAR-------DLKKKLGQLRSQLQEARDQHREAVHHAEKMEDHLQKL--ELEKSKFE 1274
Cdd:pfam15921 316 MRQLSDLESTV---SQLRSELREAKRmyedkieELEKQLVLANSELTEARTERDQFSQESGNLDDQLQKLlaDLHKREKE 392
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1275 ITIKKQSEE------------IDQLQENLSRVNLSEEDKEKLQKL--TELKESLECTVDQEQKRSSALEK------ELAE 1334
Cdd:pfam15921 393 LSLEKEQNKrlwdrdtgnsitIDHLRRELDDRNMEVQRLEALLKAmkSECQGQMERQMAAIQGKNESLEKvssltaQLES 472
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1335 FKEVLKMTKKELN----EYENRELNLrQDIKNNHLEMDIPVSTLIKKIDDLTAKLETASSKCLHLgkknqllQQELLLMR 1410
Cdd:pfam15921 473 TKEMLRKVVEELTakkmTLESSERTV-SDLTASLQEKERAIEATNAEITKLRSRVDLKLQELQHL-------KNEGDHLR 544
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1411 TIQKKCGKLEKNKKQLEQEVVNLRSHMEkNMVEhsQAQQYAREveerARQDLVEKlKQVNLFLQAQAASQESLEQLRENS 1490
Cdd:pfam15921 545 NVQTECEALKLQMAEKDKVIEILRQQIE-NMTQ--LVGQHGRT----AGAMQVEK-AQLEKEINDRRLELQEFKILKDKK 616
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124487433 1491 NASVRsQMELRIKDLESQLYRMKAQEDFDKIELEKYKQLYQEEFRARKSLSSKLNKTSEKLE 1552
Cdd:pfam15921 617 DAKIR-ELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRNELNSLSEDYE 677
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
1135-1356 |
1.66e-06 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 53.00 E-value: 1.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1135 TIVNIQDQFQDvLTRFQ-----AESQRHSLR-LEDRNQELVsecsHLRERLCQYENEKAEREVVVRQLQQELADtlKKQS 1208
Cdd:COG4913 226 AADALVEHFDD-LERAHealedAREQIELLEpIRELAERYA----AARERLAELEYLRAALRLWFAQRRLELLE--AELE 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1209 MSEASLEvssryrsNLEEEARDLKKKLGQLRSQLQEARDQHREAVHhaekmeDHLQKLELEKSKFEITIKKQSEEIDQLQ 1288
Cdd:COG4913 299 ELRAELA-------RLEAELERLEARLDALREELDELEAQIRGNGG------DRLEQLEREIERLERELEERERRRARLE 365
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124487433 1289 ENLSRVNLSEED-----KEKLQKLTELKESLECTVDQEQKRSSALEKELAEFKEVLKMTKKELNEYENRELNL 1356
Cdd:COG4913 366 ALLAALGLPLPAsaeefAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNI 438
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
133-187 |
2.10e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 46.19 E-value: 2.10e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 124487433 133 LLDHG-ADPNVMDSSGNTALHYAVYSENTSMAAKLLAHNANIEAKNKDDLTPMLLA 187
Cdd:pfam13857 1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
74-203 |
2.45e-06 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 52.39 E-value: 2.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 74 VNDRDK----KDRTALHLACAYGHPEVVTLLVERKCEIDAR----------------DSESSTALIKAVQcqEEECAAIL 133
Cdd:TIGR00870 117 ANDQYTseftPGITALHLAAHRQNYEIVKLLLERGASVPARacgdffvksqgvdsfyHGESPLNAAACLG--SPSIVALL 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 134 LDHGADPNVMDSSGNTALHYAV-----YSENTSM-------AAKLLAHNANIEA----KNKDDLTPMLLAVKENK----Q 193
Cdd:TIGR00870 195 SEDPADILTADSLGNTLLHLLVmenefKAEYEELscqmynfALSLLDKLRDSKEleviLNHQGLTPLKLAAKEGRivlfR 274
|
170
....*....|
gi 124487433 194 HIVEFLVKKK 203
Cdd:TIGR00870 275 LKLAIKYKQK 284
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
56-251 |
2.47e-06 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 51.95 E-value: 2.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 56 SVGDVAKVqhILILGKSG--VNDRDKKDRTALHL-ACAYGHPEVVTLLVERKCEIDARDSESSTALIK--AVQCQEEECA 130
Cdd:PHA03095 58 SSEKVKDI--VRLLLEAGadVNAPERCGFTPLHLyLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVI 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 131 AILLDHGADPNVMDSSGNTALHYAVYSENTSMA--AKLLAHNANIEAKNKDDLTP---MLLAVKENKQhIVEFLVKKKAS 205
Cdd:PHA03095 136 RLLLRKGADVNALDLYGMTPLAVLLKSRNANVEllRLLIDAGADVYAVDDRFRSLlhhHLQSFKPRAR-IVRELIRAGCD 214
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 124487433 206 IHAVDQLGSNRQMFEYDGKRLQRSENSNPVDNGSEDGSLTRSYNTP 251
Cdd:PHA03095 215 PAATDMLGNTPLHSMATGSSCKRSLVLPLLIAGISINARNRYGQTP 260
|
|
| sbcc |
TIGR00618 |
exonuclease SbcC; All proteins in this family for which functions are known are part of an ... |
921-1558 |
2.59e-06 |
|
exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129705 [Multi-domain] Cd Length: 1042 Bit Score: 52.66 E-value: 2.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 921 ANEKNDNLQRMVKLNEETFTKTIFQYTGQLNSLKAENTmlsskldneKQNKERLE--TDVESFRSRLASALHDHAEIQTA 998
Cdd:TIGR00618 125 KSETEEVIHDLLKLDYKTFTRVVLLPQGEFAQFLKAKS---------KEKKELLMnlFPLDQYTQLALMEFAKKKSLHGK 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 999 KRDLEIAFQrardewfRVKDKMNFDMSNLRDNNEVLSQQLSKTERKLNSLEI--EFHHTKDELREKTL----ALKHAQRD 1072
Cdd:TIGR00618 196 AELLTLRSQ-------LLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQshAYLTQKREAQEEQLkkqqLLKQLRAR 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1073 LSQTQCQMKEVEHMFQ--DEQGKVSKFMGKQESIEERLAQLQSENTLLRQQLddaaNKAESKDKTIVNIQDQFQDVLTRF 1150
Cdd:TIGR00618 269 IEELRAQEAVLEETQEriNRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKM----RSRAKLLMKRAAHVKQQSSIEEQR 344
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1151 QAESQRHslRLEDRNQELVSECSHLRERLCQyenEKAEREVVVRQLQQELADTLKKQSMSEASLEVSSRYRSNLEEEA-- 1228
Cdd:TIGR00618 345 RLLQTLH--SQEIHIRDAHEVATSIREISCQ---QHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSaf 419
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1229 RDLKKKLGQLRSQLQEardQHREAVHHAEKMEDHLQKLELEKSKFEITIKKQSEEIDQLQeNLSRVNLSEEDKEKL--QK 1306
Cdd:TIGR00618 420 RDLQGQLAHAKKQQEL---QQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQ-TKEQIHLQETRKKAVvlAR 495
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1307 LTELKEsLECTVDQE-----------------QKRSSALEKELAEFKEVLKMTKKELNEyenrELNLRQDIKNNHLEMDI 1369
Cdd:TIGR00618 496 LLELQE-EPCPLCGScihpnparqdidnpgplTRRMQRGEQTYAQLETSEEDVYHQLTS----ERKQRASLKEQMQEIQQ 570
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1370 PVSTLIKKIDDLTA---KLETASSKCLHLGKKNQLLQQelllmrtiqKKCGKLEKNKKQLEQEVVNLRSHMEKNMVEHSQ 1446
Cdd:TIGR00618 571 SFSILTQCDNRSKEdipNLQNITVRLQDLTEKLSEAED---------MLACEQHALLRKLQPEQDLQDVRLHLQQCSQEL 641
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1447 AQQ---YAREVEERARQDLVEKLKQVNLFLQAQAASQESLEQLRENSNASVRSQMElrikDLESQLYRMKAQEDfdkiEL 1523
Cdd:TIGR00618 642 ALKltaLHALQLTLTQERVREHALSIRVLPKELLASRQLALQKMQSEKEQLTYWKE----MLAQCQTLLRELET----HI 713
|
650 660 670
....*....|....*....|....*....|....*
gi 124487433 1524 EKYKQLYQEEFRARKSLSSKLNKTSEKLEEASSKL 1558
Cdd:TIGR00618 714 EEYDREFNEIENASSSLGSDLAAREDALNQSLKEL 748
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
147-200 |
3.78e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 45.73 E-value: 3.78e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 124487433 147 GNTALHYAVYSENTSMAAKLLAHNANIEAKNKDDLTPMLLAVKENKQHIVEFLV 200
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| TRPV |
cd21882 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ... |
80-205 |
5.18e-06 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).
Pssm-ID: 411975 [Multi-domain] Cd Length: 600 Bit Score: 51.42 E-value: 5.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 80 KDRTALHLACAYGHPEVVTLLVERKCEIDARdseSSTALIKAVQC----------------QEEECAAILLDHGADP--- 140
Cdd:cd21882 72 QGQTALHIAIENRNLNLVRLLVENGADVSAR---ATGRFFRKSPGnlfyfgelplslaactNQEEIVRLLLENGAQPaal 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 141 NVMDSSGNTALHYAVYSEN---------TSMAAKLLAHNANI-------EAKNKDDLTPMLLAVKENKQHIVEFLVKKKA 204
Cdd:cd21882 149 EAQDSLGNTVLHALVLQADntpensafvCQMYNLLLSYGAHLdptqqleEIPNHQGLTPLKLAAVEGKIVMFQHILQREF 228
|
.
gi 124487433 205 S 205
Cdd:cd21882 229 S 229
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
1117-1562 |
5.59e-06 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 51.31 E-value: 5.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1117 LLRQQLDDAANKAESKD-KTIVNIQDQFQDVLTRFQAESQRhslrlEDRNQELVSECSHLRERLCQYENEKAEREVVVRQ 1195
Cdd:COG4717 46 MLLERLEKEADELFKPQgRKPELNLKELKELEEELKEAEEK-----EEEYAELQEELEELEEELEELEAELEELREELEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1196 LQQELADTLKKQSMSEASLEVSS------------RYRSNLEEEARDLKKKLGQLRSQLQEARDQHREAVHHA-EKMEDH 1262
Cdd:COG4717 121 LEKLLQLLPLYQELEALEAELAElperleeleerlEELRELEEELEELEAELAELQEELEELLEQLSLATEEElQDLAEE 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1263 LQKLELEKSKFEITIKKQSEEIDQLQENLSRVNLSEEDKEKLQKLTELKESLE-----CTVDQEQKRSSALEKELAEF-K 1336
Cdd:COG4717 201 LEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLLLLiaaalLALLGLGGSLLSLILTIAGVlF 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1337 EVLKMTKKELNEYENRELNLRQDIKnnhlemDIPVSTLIKKIDDLTAKlETASSKCLHLGKKNQLLQQELLLMRTIQKKC 1416
Cdd:COG4717 281 LVLGLLALLFLLLAREKASLGKEAE------ELQALPALEELEEEELE-ELLAALGLPPDLSPEELLELLDRIEELQELL 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1417 GKLEKNKKQLEQEVV--NLRSHMEKNMVEhSQAQQYAREVEERARQDLVEKLKQVNLFLQAQA------ASQESLEQLRE 1488
Cdd:COG4717 354 REAEELEEELQLEELeqEIAALLAEAGVE-DEEELRAALEQAEEYQELKEELEELEEQLEELLgeleelLEALDEEELEE 432
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1489 ---------NSNASVRSQMELRIKDLESQLYRMKAQEDFDKIELEKYKQLYQ-----EEFRARKSLSSKLNKTSEKLEEA 1554
Cdd:COG4717 433 eleeleeelEELEEELEELREELAELEAELEQLEEDGELAELLQELEELKAElrelaEEWAALKLALELLEEAREEYREE 512
|
....*...
gi 124487433 1555 SSKLLLEE 1562
Cdd:COG4717 513 RLPPVLER 520
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
99-154 |
6.13e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 45.03 E-value: 6.13e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 124487433 99 LLVERKCEIDARDSESSTALIKAVQCQEEECAAILLDHGADPNVMDSSGNTALHYA 154
Cdd:pfam13857 1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| Cast |
pfam10174 |
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ... |
766-1427 |
6.14e-06 |
|
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.
Pssm-ID: 431111 [Multi-domain] Cd Length: 766 Bit Score: 50.98 E-value: 6.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 766 ALKQEEEKRRSADQLSEKTSEQLRRKGEQCQSEV----EARQQLEASLRTLEMELKTVKSHLNQvLEERNETQRQL--SR 839
Cdd:pfam10174 78 ALQDELRAQRDLNQLLQQDFTTSPVDGEDKFSTPelteENFRRLQSEHERQAKELFLLRKTLEE-MELRIETQKQTlgAR 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 840 EQNAR----MLQDGILASHLcKQKEIEMTQKKMTSEVSVSH------EKEKDL------LHKNQRLQDEVAVLR-----L 898
Cdd:pfam10174 157 DESIKklleMLQSKGLPKKS-GEEDWERTRRIAEAEMQLGHlevlldQKEKENihlreeLHRRNQLQPDPAKTKalqtvI 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 899 EMDTIKSHNQEKEKRYLEDikianekndnLQRMVKLNEETFTKTIFQYTGQLNSLKAENTMLSSKLDNEKQNKERLETDV 978
Cdd:pfam10174 236 EMKDTKISSLERNIRDLED----------EVQMLKTNGLLHTEDREEEIKQMEVYKSHSKFMKNKIDQLKQELSKKESEL 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 979 ESFRSRLasalhdhaeiqtakrdleiafqrardewfrvkDKMNFDMSNLRDNNEVLSQQLSKTERKLNSLEIEFhhtkDE 1058
Cdd:pfam10174 306 LALQTKL--------------------------------ETLTNQNSDCKQHIEVLKESLTAKEQRAAILQTEV----DA 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1059 LRektLALKHAQRDLSQTQCQMKEVehmfQDEQGKvskfmgkqesieerlaqLQSENTLLRQQLDDAANKAESKDKTIVN 1138
Cdd:pfam10174 350 LR---LRLEEKESFLNKKTKQLQDL----TEEKST-----------------LAGEIRDLKDMLDVKERKINVLQKKIEN 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1139 IQDQFQDvltrfqAESQRHSLRleDRNQELVSECSHLRERLCQYENEKAEREVVVRQLQQEladtlkKQSMSEASLEVSS 1218
Cdd:pfam10174 406 LQEQLRD------KDKQLAGLK--ERVKSLQTDSSNTDTALTTLEEALSEKERIIERLKEQ------REREDRERLEELE 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1219 RYRsnleEEARDLKKKLGQLRSQLQEARDQHREAVHHAEKMEDHLQKLELEKSKFEITIKKQSEEIDQLQENLSRVNLSE 1298
Cdd:pfam10174 472 SLK----KENKDLKEKVSALQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKLENQLKKAHNAE 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1299 EDKEKLQKLTELKESLECTVDQEQKRSSALEKELAEFKEVLKMTKKELNEYENRELNLRQDIKNNHLEMDIPVStlikKI 1378
Cdd:pfam10174 548 EAVRTNPEINDRIRLLEQEVARYKEESGKAQAEVERLLGILREVENEKNDKDKKIAELESLTLRQMKEQNKKVA----NI 623
|
650 660 670 680
....*....|....*....|....*....|....*....|....*....
gi 124487433 1379 DDLTAKLETASSKCLHLGKKNQLLQQELLLMRTIQKKCGKLEKNKKQLE 1427
Cdd:pfam10174 624 KHGQQEMKKKGAQLLEEARRREDNLADNSQQLQLEELMGALEKTRQELD 672
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
67-211 |
6.35e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 51.22 E-value: 6.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 67 LILGKSG--VNDRDKKDRTALHLAC-AYGHPEVVTLLVERKCEIDARDSESSTAL-IKAVQCQEEECAAILLDHGADPNV 142
Cdd:PHA02876 257 LLLYDAGfsVNSIDDCKNTPLHHASqAPSLSRLVPKLLERGADVNAKNIKGETPLyLMAKNGYDTENIRTLIMLGADVNA 336
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 143 MDSSGNTALHYA-VYSENTSMAAKLLAHNANIEAKNKDDLTPMLLAVKENKQHIVEFLVKKKASIHAVDQ 211
Cdd:PHA02876 337 ADRLYITPLHQAsTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQ 406
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
1034-1252 |
7.46e-06 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 50.15 E-value: 7.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1034 LSQQLSKTERKLNSLEIEFHHTKDELREKTLALKHAQRDLSQTQCQMKEVEhmfqdeqGKVSKFMGKQESIEERLAQLQS 1113
Cdd:COG4942 32 LQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALE-------AELAELEKEIAELRAELEAQKE 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1114 EntlLRQQLDDA-ANKAESKDKTIVNiQDQFQDVLTRFQAeSQRHSLRLEDRNQELVSECSHLRERLCQYENEKAEREVV 1192
Cdd:COG4942 105 E---LAELLRALyRLGRQPPLALLLS-PEDFLDAVRRLQY-LKYLAPARREQAEELRADLAELAALRAELEAERAELEAL 179
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1193 VRQLQQELADTLKKQSMSEASLEVSSRYRSNLEEEARDLKKKLGQLRSQLQEARDQHREA 1252
Cdd:COG4942 180 LAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAA 239
|
|
| 235kDa-fam |
TIGR01612 |
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ... |
814-1456 |
8.21e-06 |
|
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.
Pssm-ID: 130673 [Multi-domain] Cd Length: 2757 Bit Score: 51.21 E-value: 8.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 814 MELKTVKSHLNQVLEERNETqrqLSREQNARMLQDGILASHLCKQKEIEMTQKKMTSEVSVSHEKEKDLLHKNQRLQDEV 893
Cdd:TIGR01612 715 METATVELHLSNIENKKNEL---LDIIVEIKKHIHGEINKDLNKILEDFKNKEKELSNKINDYAKEKDELNKYKSKISEI 791
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 894 AVL---RLEMDTIKS----HNQEKEKRYLEDIKIANEKNDNLQRMVKLNEETFTKTIFQYTG-------QLNSLKAENTM 959
Cdd:TIGR01612 792 KNHyndQINIDNIKDedakQNYDKSKEYIKTISIKEDEIFKIINEMKFMKDDFLNKVDKFINfennckeKIDSEHEQFAE 871
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 960 LSSKLDNEKQNK-----ERLETDVESFRSRLASALH-DHAEIQTAKRdleiafqraRDEWFRVKDKMNFDMSNLRDNNEV 1033
Cdd:TIGR01612 872 LTNKIKAEISDDklndyEKKFNDSKSLINEINKSIEeEYQNINTLKK---------VDEYIKICENTKESIEKFHNKQNI 942
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1034 LSQQLSK---TERKLNSLEIEFHHTKDE-LREKTLALKHAQRDLSqtqcqmkevehmFQDEQGKVSKFMGKQESIEERLA 1109
Cdd:TIGR01612 943 LKEILNKnidTIKESNLIEKSYKDKFDNtLIDKINELDKAFKDAS------------LNDYEAKNNELIKYFNDLKANLG 1010
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1110 QlQSENTLLRQ------QLDDAANKAESKDKTIVNIQDQFQDVLTRFQAESQRH-SLRLEDRNQELVsecshlrerlcqy 1182
Cdd:TIGR01612 1011 K-NKENMLYHQfdekekATNDIEQKIEDANKNIPNIEIAIHTSIYNIIDEIEKEiGKNIELLNKEIL------------- 1076
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1183 enEKAEREVVVRQlqqELADTLKKQSMSEASLEVSSRYRSNLEEEARDLKKKLGQLRSQLQEARDQHREAVHHAEKMEDH 1262
Cdd:TIGR01612 1077 --EEAEINITNFN---EIKEKLKHYNFDDFGKEENIKYADEINKIKDDIKNLDQKIDHHIKALEEIKKKSENYIDEIKAQ 1151
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1263 LQKLE--------------LEKSKFEITIK--KQSEEIDQLQENLSRVNLSEEDKEKLQKLTELKES---------LEcT 1317
Cdd:TIGR01612 1152 INDLEdvadkaisnddpeeIEKKIENIVTKidKKKNIYDEIKKLLNEIAEIEKDKTSLEEVKGINLSygknlgklfLE-K 1230
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1318 VDQEQKRSSALEKELAEFKEVLKMTKKELNEYENrELNLRQDIKNNHLEMDIPVS------TLIKKIDDLTAKLEtasSK 1391
Cdd:TIGR01612 1231 IDEEKKKSEHMIKAMEAYIEDLDEIKEKSPEIEN-EMGIEMDIKAEMETFNISHDddkdhhIISKKHDENISDIR---EK 1306
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1392 CLHLGKKNQLLQQELLLMRTIQKKCGKLEKNKKQLEQ---EVVNLRSHMEKNMVEH--SQAQQYAREVEE 1456
Cdd:TIGR01612 1307 SLKIIEDFSEESDINDIKKELQKNLLDAQKHNSDINLylnEIANIYNILKLNKIKKiiDEVKEYTKEIEE 1376
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
51-212 |
8.33e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 50.35 E-value: 8.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 51 IHKAASVGDVAKVQHILILGkSGVNDRDKKDRTALHLACAYGHPEVVTLLVERKCEIDARDSESSTALIKAVQCQEEECA 130
Cdd:PHA02874 128 LHYAIKKGDLESIKMLFEYG-ADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACI 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 131 AILLDHG-------------------------------ADPNVMDSSGNTALHYAV-YSENTSMAAKLLAHNANIEAKNK 178
Cdd:PHA02874 207 KLLIDHGnhimnkckngftplhnaiihnrsaiellinnASINDQDIDGSTPLHHAInPPCDIDIIDILLYHKADISIKDN 286
|
170 180 190
....*....|....*....|....*....|....*
gi 124487433 179 DDLTPMLLAVKE-NKQHIVEFLVKKKASIHAVDQL 212
Cdd:PHA02874 287 KGENPIDTAFKYiNKDPVIKDIIANAVLIKEADKL 321
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
52-136 |
8.94e-06 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 50.67 E-value: 8.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 52 HKAASvGDVAKVQhILILGKSGVNDRDKKDRTALHLACAYGHPEVVTLLVERKCEIDARDSESSTALIKAVQCQEEECAA 131
Cdd:PTZ00322 88 QLAAS-GDAVGAR-ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165
|
....*
gi 124487433 132 ILLDH 136
Cdd:PTZ00322 166 LLSRH 170
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
98-213 |
1.00e-05 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 50.40 E-value: 1.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 98 TLLVERKCEIDARDSESSTALIKAVQCQEEECAAILLDhgADP----NVMDSS---GNTALHYAVYSENTSMAAKLLAHN 170
Cdd:cd22192 35 KLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLME--AAPelvnEPMTSDlyqGETALHIAVVNQNLNLVRELIARG 112
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 124487433 171 ANIEA---------KNKDDLT-----PMLLAVKENKQHIVEFLVKKKASIHAVDQLG 213
Cdd:cd22192 113 ADVVSpratgtffrPGPKNLIyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLG 169
|
|
| MAD |
pfam05557 |
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ... |
1037-1574 |
1.00e-05 |
|
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.
Pssm-ID: 461677 [Multi-domain] Cd Length: 660 Bit Score: 50.51 E-value: 1.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1037 QLSKTERKLNSLEIEFHHTKDELREKTLALKhaqRDLSQTQCQMKEVehmfqdeQGKVSKfMGKQESIEERLAQLQSENT 1116
Cdd:pfam05557 10 RLSQLQNEKKQMELEHKRARIELEKKASALK---RQLDRESDRNQEL-------QKRIRL-LEKREAEAEEALREQAELN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1117 LLRQQLDDAANKAESKDKTIVNIQDQFQDVLTRFQAESQRHSLRLEDRNQELVSECSHLRERLCQYENEKAEREVVVRQL 1196
Cdd:pfam05557 79 RLKKKYLEALNKKLNEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQNL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1197 QQeladtlKKQSMSEAslevssryrsnlEEEARDLKKKLGQLRSQLQEARDQHREAVHHAEkMEDHLQKLElekskfeit 1276
Cdd:pfam05557 159 EK------QQSSLAEA------------EQRIKELEFEIQSQEQDSEIVKNSKSELARIPE-LEKELERLR--------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1277 ikkqsEEIDQLQENLSRVNLSEEDKEKLQKLTELKESLECTVDQEQKRSSALEKELAEFKEVLKMTKKELN--------- 1347
Cdd:pfam05557 211 -----EHNKHLNENIENKLLLKEEVEDLKRKLEREEKYREEAATLELEKEKLEQELQSWVKLAQDTGLNLRspedlsrri 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1348 -EYENRELNLRQD----------IKNNHLEMDIPVSTLIKKIDDLTAKLETASSKCLHLGKKNQLLQQELLLMR------ 1410
Cdd:pfam05557 286 eQLQQREIVLKEEnssltssarqLEKARRELEQELAQYLKKIEDLNKKLKRHKALVRRLQRRVLLLTKERDGYRailesy 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1411 ----TIQKKCGKLEKNKKQLEQEVVNLRSHMEKNMVEHSQAQQYAREVEERARQDLVE--KLKQVNLFLQAQAASQESLE 1484
Cdd:pfam05557 366 dkelTMSNYSPQLLERIEEAEDMTQKMQAHNEEMEAQLSVAEEELGGYKQQAQTLERElqALRQQESLADPSYSKEEVDS 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1485 QLRENSNASV-RSQMELRIKDLESQLYRMKAQEDFDkieLEKYKQLY------QEEFRARKSLSSKLNKTSEKLEEASSK 1557
Cdd:pfam05557 446 LRRKLETLELeRQRLREQKNELEMELERRCLQGDYD---PKKTKVLHlsmnpaAEAYQQRKNQLEKLQAEIERLKRLLKK 522
|
570
....*....|....*..
gi 124487433 1558 LLLEEQQNRSLLSTLST 1574
Cdd:pfam05557 523 LEDDLEQVLRLPETTST 539
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
949-1266 |
1.16e-05 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 50.30 E-value: 1.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 949 QLNSLKAENTMLSSKLDNEKQNKERLETDVESFRSRLaSALHDHAEIQTAKRDLEIAfQRARDEWFRVKDKMNFDMSNLR 1028
Cdd:COG4913 611 KLAALEAELAELEEELAEAEERLEALEAELDALQERR-EALQRLAEYSWDEIDVASA-EREIAELEAELERLDASSDDLA 688
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1029 dnneVLSQQLSKTERKLNSLEIEFHHTKDELREKTLALKHAQRDLSQTQCQMKEVEHMFQDEQgkvskfmgkQESIEERL 1108
Cdd:COG4913 689 ----ALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLEL---------RALLEERF 755
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1109 AQLQSENTL------LRQQLDDAANKAESKDKTIVNIQDQFQDvltRFQAESQRHSLRLEDrNQELVSECSHL------- 1175
Cdd:COG4913 756 AAALGDAVErelrenLEERIDALRARLNRAEEELERAMRAFNR---EWPAETADLDADLES-LPEYLALLDRLeedglpe 831
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1176 -RERLCQYENEKAEREVVvrQLQQELADTLK--KQSMSE--ASLEVSS---------RYRSNLEEEARDLKKKLGQLRSQ 1241
Cdd:COG4913 832 yEERFKELLNENSIEFVA--DLLSKLRRAIReiKERIDPlnDSLKRIPfgpgrylrlEARPRPDPEVREFRQELRAVTSG 909
|
330 340
....*....|....*....|....*
gi 124487433 1242 LQEARDQHREavHHAEKMEDHLQKL 1266
Cdd:COG4913 910 ASLFDEELSE--ARFAALKRLIERL 932
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
1322-1575 |
1.63e-05 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 48.99 E-value: 1.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1322 QKRSSALEKELAEFKEVLKMTKKELNEYENRELNLRQDIKNnhlemdipvstLIKKIDDLTAKLETASSKclhlgkknql 1401
Cdd:COG4942 19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAA-----------LERRIAALARRIRALEQE---------- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1402 lqqelllMRTIQKKCGKLEKNKKQLEQEVVNLRSHMEKNMVEHSQAQQYAREVEERARQDLVEKLKQVNLFLQAQAASQE 1481
Cdd:COG4942 78 -------LAALEAELAELEKEIAELRAELEAQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARRE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1482 SLEQLRENSNasvrsqmelRIKDLESQLYRMKAQEDFDKIELEKYKQLYQEEFRARKSLSSKLNKTSEKLEEASSKLLLE 1561
Cdd:COG4942 151 QAEELRADLA---------ELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQE 221
|
250
....*....|....
gi 124487433 1562 EQQNRSLLSTLSTR 1575
Cdd:COG4942 222 AEELEALIARLEAE 235
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
708-979 |
1.67e-05 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 50.14 E-value: 1.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 708 KRLIELKRSHCELLTGKLK--RMENKYKGLQKEMSETEEVKSRLEHEKVGWEQELCRLRFALKQEEEKRRSADQLSEKTS 785
Cdd:PTZ00121 1592 ARIEEVMKLYEEEKKMKAEeaKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAE 1671
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 786 EQlRRKGEQCQSEVEARQQLEASLRTLEMELKTVKsHLNQVLEERNETQRQLSREQNARMLQdgilASHLCKQKEIEmtq 865
Cdd:PTZ00121 1672 ED-KKKAEEAKKAEEDEKKAAEALKKEAEEAKKAE-ELKKKEAEEKKKAEELKKAEEENKIK----AEEAKKEAEED--- 1742
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 866 KKMTSEVSVSHEKEKDLLHKNQRLQDEVAVLRLEMDTI--KSHNQEKEKRYLEDIKIANEKNDNLQRM----------VK 933
Cdd:PTZ00121 1743 KKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVieEELDEEDEKRRMEVDKKIKDIFDNFANIieggkegnlvIN 1822
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 124487433 934 LNEETF-----------------TKTIFQYTGQLNSLKAENTMLSSKLDNEKQNKERLETDVE 979
Cdd:PTZ00121 1823 DSKEMEdsaikevadsknmqleeADAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIE 1885
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
54-213 |
1.91e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 49.19 E-value: 1.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 54 AASVGDVaKVQHILILGKSGVNDRDKKDRTALHLACAYGHPEVVTLLVerkceIDARDSEsstalIKAVQCQEEECAAIL 133
Cdd:PHA02874 42 AIRSGDA-KIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLI-----DNGVDTS-----ILPIPCIEKDMIKTI 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 134 LDHGADPNVMDSSGNTALHYAVYSENTSMAAKLLAHNANIEAKNKDDLTPMLLAVKENKQHIVEFLVKKKASIHAVDQLG 213
Cdd:PHA02874 111 LDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNG 190
|
|
| PRK11281 |
PRK11281 |
mechanosensitive channel MscK; |
1101-1358 |
2.35e-05 |
|
mechanosensitive channel MscK;
Pssm-ID: 236892 [Multi-domain] Cd Length: 1113 Bit Score: 49.52 E-value: 2.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1101 QESIEERLAQL------QSENTLLRQQLDDAANKAESKDKTIVNIQDQFQDVL-TRFQAESQRhslRLEDRNQELVSECS 1173
Cdd:PRK11281 62 QQDLEQTLALLdkidrqKEETEQLKQQLAQAPAKLRQAQAELEALKDDNDEETrETLSTLSLR---QLESRLAQTLDQLQ 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1174 HLRERLCQYEN---------EKAEREVVVRQLQ-QELADTLKKQSMSEASLEVSSRYRSNLEEEARDLK----KKLGQLR 1239
Cdd:PRK11281 139 NAQNDLAEYNSqlvslqtqpERAQAALYANSQRlQQIRNLLKGGKVGGKALRPSQRVLLQAEQALLNAQndlqRKSLEGN 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1240 SQLQEARDQHREavhhaEKMEdHLQKLElekskfeitikkqsEEIDQLQENLSRVNLsEEDKEKLQKLTELKESLECTVD 1319
Cdd:PRK11281 219 TQLQDLLQKQRD-----YLTA-RIQRLE--------------HQLQLLQEAINSKRL-TLSEKTVQEAQSQDEAARIQAN 277
|
250 260 270
....*....|....*....|....*....|....*....
gi 124487433 1320 QEQKRSSALEKELAEFkeVLKMTKKeLNEYENRELNLRQ 1358
Cdd:PRK11281 278 PLVAQELEINLQLSQR--LLKATEK-LNTLTQQNLRVKN 313
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
1094-1358 |
2.65e-05 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 48.86 E-value: 2.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1094 VSKFMGKQESIEERLAQLQSENTLLR----QQLDDAANKAESKDKTIVNiqdqfqDVLTRFQAESQRHS----LRLEDRN 1165
Cdd:COG3206 73 LSSLSASDSPLETQIEILKSRPVLERvvdkLNLDEDPLGEEASREAAIE------RLRKNLTVEPVKGSnvieISYTSPD 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1166 QEL-------VSEcSHLRERLcqyENEKAEREVVVRQLQQELADTLKKQSMSEASLEvssRYRS-----NLEEEARDLKK 1233
Cdd:COG3206 147 PELaaavanaLAE-AYLEQNL---ELRREEARKALEFLEEQLPELRKELEEAEAALE---EFRQknglvDLSEEAKLLLQ 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1234 KLGQLRSQLQEARDQHREAVHHAEKMEDhlqklELEKSKFEITIKKQSEEIDQLQENLSRVNLSEEDKE--------KLQ 1305
Cdd:COG3206 220 QLSELESQLAEARAELAEAEARLAALRA-----QLGSGPDALPELLQSPVIQQLRAQLAELEAELAELSarytpnhpDVI 294
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 124487433 1306 KLTELKESLECTVDQEQKRS-SALEKELAEFKEVLKMTKKELNEYENRELNLRQ 1358
Cdd:COG3206 295 ALRAQIAALRAQLQQEAQRIlASLEAELEALQAREASLQAQLAQLEARLAELPE 348
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
51-101 |
2.80e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 43.03 E-value: 2.80e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 124487433 51 IHKAASVGDVAKVQHILILGKSgVNDRDKKDRTALHLACAYGHPEVVTLLV 101
Cdd:pfam13637 5 LHAAAASGHLELLRLLLEKGAD-INAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
95-206 |
2.96e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 48.42 E-value: 2.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 95 EVVTLLVERKCEIDARDSESSTALIKAVQCQEEECAAILLDHGADPNVMDSSGNTALHYAVYSENTSMAAKLLAHNANIE 174
Cdd:PHA02874 105 DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYAN 184
|
90 100 110
....*....|....*....|....*....|..
gi 124487433 175 AKNKDDLTPMLLAVKENKQHIVEFLVKKKASI 206
Cdd:PHA02874 185 VKDNNGESPLHNAAEYGDYACIKLLIDHGNHI 216
|
|
| Cast |
pfam10174 |
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ... |
1033-1555 |
3.08e-05 |
|
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.
Pssm-ID: 431111 [Multi-domain] Cd Length: 766 Bit Score: 49.05 E-value: 3.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1033 VLSQQLSKTERKLNSLEIEFHHTKDELRektlalkhAQRDLSQTqcqmkeVEHMFQDEQGKVSKFMGKQESIEERLAQLQ 1112
Cdd:pfam10174 57 VLKEQYRVTQEENQHLQLTIQALQDELR--------AQRDLNQL------LQQDFTTSPVDGEDKFSTPELTEENFRRLQ 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1113 S-------ENTLLRQQLDDAANKAESKDKTIVNIQDQFQDVLTRFQAESQRHSLRLED-----RNQELVSECSHLRERLC 1180
Cdd:pfam10174 123 SeherqakELFLLRKTLEEMELRIETQKQTLGARDESIKKLLEMLQSKGLPKKSGEEDwertrRIAEAEMQLGHLEVLLD 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1181 QYENEKAE-REVVVR--QLQQELADTLKKQSMseasLEVSSRYRSNLEEEARDLKKKLGQLRSQLQEARDQHREAVHHAE 1257
Cdd:pfam10174 203 QKEKENIHlREELHRrnQLQPDPAKTKALQTV----IEMKDTKISSLERNIRDLEDEVQMLKTNGLLHTEDREEEIKQME 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1258 KMEDH--LQKLELEKSKFEITiKKQSEeIDQLQENLSRVNLSEEDKEklQKLTELKESLECtvdqEQKRSSALEKELAEF 1335
Cdd:pfam10174 279 VYKSHskFMKNKIDQLKQELS-KKESE-LLALQTKLETLTNQNSDCK--QHIEVLKESLTA----KEQRAAILQTEVDAL 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1336 KEVLKMTKKELNEYENRELNLRQDiknnhlemdipVSTLIKKIDDLTAKLETASSKCLHLGKKnqlLQQELLLMRTIQKK 1415
Cdd:pfam10174 351 RLRLEEKESFLNKKTKQLQDLTEE-----------KSTLAGEIRDLKDMLDVKERKINVLQKK---IENLQEQLRDKDKQ 416
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1416 CGKLEKNKKQLEQEVVNLRSH---MEKNMVEHS---QAQQYAREVEERARQDLVEKLKQVNL-------FLQAQAASQE- 1481
Cdd:pfam10174 417 LAGLKERVKSLQTDSSNTDTAlttLEEALSEKEriiERLKEQREREDRERLEELESLKKENKdlkekvsALQPELTEKEs 496
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1482 SLEQLRE--NSNASVRSQMELRIKDLESQLYRMKaqEDFDKIELEKYK-QLYQEEFRARKSLSSKL----NKTSEKLEEA 1554
Cdd:pfam10174 497 SLIDLKEhaSSLASSGLKKDSKLKSLEIAVEQKK--EECSKLENQLKKaHNAEEAVRTNPEINDRIrlleQEVARYKEES 574
|
.
gi 124487433 1555 S 1555
Cdd:pfam10174 575 G 575
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
684-1112 |
3.18e-05 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 48.91 E-value: 3.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 684 IEHLRLECKD----TASLLKIRDAVYSYKRLIELKRSHCELLTG---KLKRMENKYKGLQKEMSETEEVKSRLEH---EK 753
Cdd:PRK03918 268 IEELKKEIEEleekVKELKELKEKAEEYIKLSEFYEEYLDELREiekRLSRLEEEINGIEERIKELEEKEERLEElkkKL 347
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 754 VGWEQELCRLR-------FALKQEEEKRRSADQLSEKTSEQLRRKGEQCQSEVEARQQLEASLRTLEMELKTVKSHLNQV 826
Cdd:PRK03918 348 KELEKRLEELEerhelyeEAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKA 427
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 827 LEERNETQ-------RQLSREQNARmlqdgILASHLCKQKEIEMTQKKMTSEVSvSHEKEKDLLHKNQRLQDEVAVLRLE 899
Cdd:PRK03918 428 IEELKKAKgkcpvcgRELTEEHRKE-----LLEEYTAELKRIEKELKEIEEKER-KLRKELRELEKVLKKESELIKLKEL 501
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 900 MDTIKSHNQEKEKRYLEDIKIANEKNDNL-QRMVKLNEEtfTKTIFQYTGQLNSLKAENTMLSSKLDNEKQNKERLET-- 976
Cdd:PRK03918 502 AEQLKELEEKLKKYNLEELEKKAEEYEKLkEKLIKLKGE--IKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKel 579
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 977 ---------DVESFRSRLASALHDHAEIQTAKRDLEIAFQRARDEwfRVKDKMNFDMSNLRDNN-EVLSQQLSKTERKLN 1046
Cdd:PRK03918 580 eelgfesveELEERLKELEPFYNEYLELKDAEKELEREEKELKKL--EEELDKAFEELAETEKRlEELRKELEELEKKYS 657
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124487433 1047 slEIEFHHTKDELREKTLALKHAQRDLSQTQCQMKEVEHMFQD---EQGKVSKFMGKQESIEERLAQLQ 1112
Cdd:PRK03918 658 --EEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKlkeELEEREKAKKELEKLEKALERVE 724
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
82-111 |
3.70e-05 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 42.28 E-value: 3.70e-05
10 20 30
....*....|....*....|....*....|.
gi 124487433 82 RTALHLACA-YGHPEVVTLLVERKCEIDARD 111
Cdd:pfam00023 3 NTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
|
|
| DUF3584 |
pfam12128 |
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
731-1340 |
4.32e-05 |
|
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.
Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 48.68 E-value: 4.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 731 KYKGLQKEMSETEEVKSRLEHEKVGWEQElcRLRFALKQEEEKRRSADQlsektSEQLRRKGEQCQSEV-EARQQL---E 806
Cdd:pfam12128 242 EFTKLQQEFNTLESAELRLSHLHFGYKSD--ETLIASRQEERQETSAEL-----NQLLRTLDDQWKEKRdELNGELsaaD 314
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 807 ASLRTLEMELKTVKSHLNQVLEERNET----QRQLSREQNARMLQDGILASHLCKQKEIEMTQKKMTSEVSVSHEKEKDL 882
Cdd:pfam12128 315 AAVAKDRSELEALEDQHGAFLDADIETaaadQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKIKEQNNRDIAG 394
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 883 LHKNQRLQDEVAVLRLEMDTIKSHNQEKEKRYLEDIKIANEKNDNLQRMVKLNEETFTKTIFQYTGQLNSLKAENTMLSS 962
Cdd:pfam12128 395 IKDKLAKIREARDRQLAVAEDDLQALESELREQLEAGKLEFNEEEYRLKSRLGELKLRLNQATATPELLLQLENFDERIE 474
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 963 KLDNEKQ----NKERLETDVESFRSRLASALHDH-------AEIQTAKRDLE----------IAFQRA-----RDEWFRV 1016
Cdd:pfam12128 475 RAREEQEaanaEVERLQSELRQARKRRDQASEALrqasrrlEERQSALDELElqlfpqagtlLHFLRKeapdwEQSIGKV 554
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1017 KDKMNFDMSNL--RDNNEVLSQQLSKTERKLNSLEI---EFHHTKDELREKTLALKHAQRDLSQTQCQMKEvehmfqdEQ 1091
Cdd:pfam12128 555 ISPELLHRTDLdpEVWDGSVGGELNLYGVKLDLKRIdvpEWAASEEELRERLDKAEEALQSAREKQAAAEE-------QL 627
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1092 GKVSKFMGKQESIEERLAQL--QSENTLLR-----QQLDDAANKA--ESKDKTIVNIQD----------QFQDVLTRFQA 1152
Cdd:pfam12128 628 VQANGELEKASREETFARTAlkNARLDLRRlfdekQSEKDKKNKAlaERKDSANERLNSleaqlkqldkKHQAWLEEQKE 707
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1153 ESQRHSLRLEDRNQELVSECSHLRERLCQ-YENEKAEREVVVRQLQQELADTLKKQSMSEASLEVSSRYRSNLE---EEA 1228
Cdd:pfam12128 708 QKREARTEKQAYWQVVEGALDAQLALLKAaIAARRSGAKAELKALETWYKRDLASLGVDPDVIAKLKREIRTLErkiERI 787
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1229 RDLKKKLGQLRSQLQEARDQHREAV--------HHAEKMEDHL-----------QKLELEKSKFEITIKKQSEEIDQLQE 1289
Cdd:pfam12128 788 AVRRQEVLRYFDWYQETWLQRRPRLatqlsnieRAISELQQQLarliadtklrrAKLEMERKASEKQQVRLSENLRGLRC 867
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....
gi 124487433 1290 NLSRVNLSEEDKEKLQKLTELKESLECTVDQEQKR---SSALEKELAEFKEVLK 1340
Cdd:pfam12128 868 EMSKLATLKEDANSEQAQGSIGERLAQLEDLKLKRdylSESVKKYVEHFKNVIA 921
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
1224-1391 |
5.00e-05 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 46.46 E-value: 5.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1224 LEEEARDLKKKLGQLRSQLQEARDQHreavhhaEKMEDHLQKLELEKSKFEITIKKQSEEIDQLQENLSRVNLSEEdkek 1303
Cdd:COG1579 22 LEHRLKELPAELAELEDELAALEARL-------EAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNKE---- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1304 LQKLTELKESLEctvdqeqKRSSALEKELAEFKEVLKMTKKELNEYENRELNLRQDIKNNHLEMDIPVSTLIKKIDDLTA 1383
Cdd:COG1579 91 YEALQKEIESLK-------RRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEA 163
|
....*...
gi 124487433 1384 KLETASSK 1391
Cdd:COG1579 164 EREELAAK 171
|
|
| DUF3584 |
pfam12128 |
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ... |
732-1477 |
5.38e-05 |
|
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.
Pssm-ID: 432349 [Multi-domain] Cd Length: 1191 Bit Score: 48.30 E-value: 5.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 732 YKGLQKEMSETEEVKSRLEHEKVGwEQELCRLRFALKQEEekRRSADQLsektseqlrrkgEQCQsevEARQQLEASLRT 811
Cdd:pfam12128 233 IAGIMKIRPEFTKLQQEFNTLESA-ELRLSHLHFGYKSDE--TLIASRQ------------EERQ---ETSAELNQLLRT 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 812 LEMELKTVKSHLNQVLE------ERNETQRQLSREQNARMLQDGILASHLCKQKEiemtqKKMTSEVSVSHEKEKDLLHK 885
Cdd:pfam12128 295 LDDQWKEKRDELNGELSaadaavAKDRSELEALEDQHGAFLDADIETAAADQEQL-----PSWQSELENLEERLKALTGK 369
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 886 NQRLQDevavlrlEMDTIKSHNQEKEKRYLEDIkiaNEKNDNlQRMVKLNEETFTKTIFQytGQLNSLKAEntmLSSKLD 965
Cdd:pfam12128 370 HQDVTA-------KYNRRRSKIKEQNNRDIAGI---KDKLAK-IREARDRQLAVAEDDLQ--ALESELREQ---LEAGKL 433
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 966 NEKQNKERLETDVESFRSRLASALHDhAEIQTAKRDLEIAFQRARDEwfrvkdkmnfdmsnlrdnnevlsqqLSKTERKL 1045
Cdd:pfam12128 434 EFNEEEYRLKSRLGELKLRLNQATAT-PELLLQLENFDERIERAREE-------------------------QEAANAEV 487
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1046 NSLEIEFHHTKDELREKTLALKHAQRDLSQTQCQMKEVEHMFQDEQGKVSKFMGKQESI-EERLAQLQSENTLLRQQLDD 1124
Cdd:pfam12128 488 ERLQSELRQARKRRDQASEALRQASRRLEERQSALDELELQLFPQAGTLLHFLRKEAPDwEQSIGKVISPELLHRTDLDP 567
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1125 AANKAESKDktivniQDQFQDVLTRFQAESQRHSLRLEDRnqelvsecshLRERLCQYENEKAEREVVVRQLQQELADTL 1204
Cdd:pfam12128 568 EVWDGSVGG------ELNLYGVKLDLKRIDVPEWAASEEE----------LRERLDKAEEALQSAREKQAAAEEQLVQAN 631
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1205 KKQSMSEASLEVSSRYRSNLEEEARDLKKKLGQLRSQLQEARDQHReavhhaEKMEDHLQKLELEKSKFEITIKKQSEEI 1284
Cdd:pfam12128 632 GELEKASREETFARTALKNARLDLRRLFDEKQSEKDKKNKALAERK------DSANERLNSLEAQLKQLDKKHQAWLEEQ 705
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1285 -DQLQENlsrvnlSEEDKEKLQKLTELKESLECTVDQE-QKRSSALEKELAEFKEVLKMTKKELNEYENRELNLRQDIKN 1362
Cdd:pfam12128 706 kEQKREA------RTEKQAYWQVVEGALDAQLALLKAAiAARRSGAKAELKALETWYKRDLASLGVDPDVIAKLKREIRT 779
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1363 NHLEM--------------DIPVSTLIKKIDDLTAKLETASSKCLHL-GKKNQLLQQELLLMRTIQKKCGKLEKNKKQLE 1427
Cdd:pfam12128 780 LERKIeriavrrqevlryfDWYQETWLQRRPRLATQLSNIERAISELqQQLARLIADTKLRRAKLEMERKASEKQQVRLS 859
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|..
gi 124487433 1428 QEVVNLRSHMEK--NMVEHSQAQQYAREVEERARQdlVEKLKQVNLFLQAQA 1477
Cdd:pfam12128 860 ENLRGLRCEMSKlaTLKEDANSEQAQGSIGERLAQ--LEDLKLKRDYLSESV 909
|
|
| SMC_prok_A |
TIGR02169 |
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ... |
1271-1573 |
6.01e-05 |
|
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain] Cd Length: 1164 Bit Score: 48.14 E-value: 6.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1271 SKFEITIKKQSEEIDQLQENLSRVNLSE--------------EDKEKLQKLTELKESLECTVDQEQKRS-----SALEKE 1331
Cdd:TIGR02169 166 AEFDRKKEKALEELEEVEENIERLDLIIdekrqqlerlrrerEKAERYQALLKEKREYEGYELLKEKEAlerqkEAIERQ 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1332 LAEFKEVLKMTKKELNEYENRELNLRQDIKNNHLEMDIPVS----TLIKKIDDLTAKLETASSKclhLGKKNQLLQQELL 1407
Cdd:TIGR02169 246 LASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEeeqlRVKEKIGELEAEIASLERS---IAEKERELEDAEE 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1408 LMRTIQKKCGKLEKNKKQLEQEVVNLRSHMEKNMVEHSQaqqyAREVEERARQDLVEKLKQVNLFLQAQAASQESLEQLR 1487
Cdd:TIGR02169 323 RLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAE----LKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLK 398
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1488 ENSNASVRSQMEL--RIKDLESQLYRMKAqedfdkiELEKYKQLYQEEFRARKSLSSKLNKTSEKLEEASSKLLLEEQQN 1565
Cdd:TIGR02169 399 REINELKRELDRLqeELQRLSEELADLNA-------AIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQEL 471
|
....*...
gi 124487433 1566 RSLLSTLS 1573
Cdd:TIGR02169 472 YDLKEEYD 479
|
|
| HOOK |
pfam05622 |
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ... |
871-1293 |
7.23e-05 |
|
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.
Pssm-ID: 461694 [Multi-domain] Cd Length: 528 Bit Score: 47.38 E-value: 7.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 871 EVSVSHEKEKDLLHKNQRLQDEVAVLrlemdtikshnQEKEKRYLEDIKIANEKNDNLQRMVKLNEETFTKtIFQYTGQL 950
Cdd:pfam05622 1 DLSEAQEEKDELAQRCHELDQQVSLL-----------QEEKNSLQQENKKLQERLDQLESGDDSGTPGGKK-YLLLQKQL 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 951 NSLKAENTMLSSKLDNEKQNKERLETDVESFRSRLASALHDHAEIQTAKRDLEIaFQRARDEWFRV-------KDKMNfD 1023
Cdd:pfam05622 69 EQLQEENFRLETARDDYRIKCEELEKEVLELQHRNEELTSLAEEAQALKDEMDI-LRESSDKVKKLeatvetyKKKLE-D 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1024 MSNLRdnNEVLSQQLSKTERKLNSLEIEfhhtkDELReKTLALKhAQRDLSQTQCQmkEVEHMFQDEQGKVSKFMGKQES 1103
Cdd:pfam05622 147 LGDLR--RQVKLLEERNAEYMQRTLQLE-----EELK-KANALR-GQLETYKRQVQ--ELHGKLSEESKKADKLEFEYKK 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1104 IEERLAQLQSENTLLRQQLDdaANKAESKDKTIVNIQdqfQDVLTRFQAESQRHSLRLEDRNQELVSecSHLRERLcqye 1183
Cdd:pfam05622 216 LEEKLEALQKEKERLIIERD--TLRETNEELRCAQLQ---QAELSQADALLSPSSDPGDNLAAEIMP--AEIREKL---- 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1184 nEKAEREVVVRQLQQELADTlKKQSMSEASLEVSSRYRSNLEEEARDLKKKLGQLRSQLQEARDQHREAVHHAE------ 1257
Cdd:pfam05622 285 -IRLQHENKMLRLGQEGSYR-ERLTELQQLLEDANRRKNELETQNRLANQRILELQQQVEELQKALQEQGSKAEdssllk 362
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 124487433 1258 -KMEDHLQKL-----ELEKSKFEITIKKQ------SEEIDQLQENLSR 1293
Cdd:pfam05622 363 qKLEEHLEKLheaqsELQKKKEQIEELEPkqdsnlAQKIDELQEALRK 410
|
|
| TRPV3 |
cd22194 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ... |
80-207 |
7.72e-05 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411978 [Multi-domain] Cd Length: 680 Bit Score: 47.45 E-value: 7.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 80 KDRTALHLACAYGHPEVVTLLVERKCEIDARDSE--------------SSTALIKAVQCQEEECAAILLDHGADPNVM-D 144
Cdd:cd22194 140 EGQTALNIAIERRQGDIVKLLIAKGADVNAHAKGvffnpkykhegfyfGETPLALAACTNQPEIVQLLMEKESTDITSqD 219
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124487433 145 SSGNTALHYAVY----SEN-----TSMAAKLL--AHNANIEA-KNKDDLTPMLLAVKENK----QHIVEFLVKKKASIH 207
Cdd:cd22194 220 SRGNTVLHALVTvaedSKTqndfvKRMYDMILlkSENKNLETiRNNEGLTPLQLAAKMGKaeilKYILSREIKEKPNRS 298
|
|
| CALCOCO1 |
pfam07888 |
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ... |
972-1349 |
7.74e-05 |
|
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.
Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 47.20 E-value: 7.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 972 ERLETDVESFRSRLASALHDHAEIQTAKRDLEIAFQRARDEWFRVKDKMNFDMSNLRDNNEVLSQQLSKTERKLNSLEI- 1050
Cdd:pfam07888 30 ELLQNRLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSAs 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1051 --EFHHTKDELREKTLALKHAQRDLSQ------TQCQMKEVEHMFQDEQGKVSKFMGKQESIEER-----LAQLQSENTL 1117
Cdd:pfam07888 110 seELSEEKDALLAQRAAHEARIRELEEdiktltQRVLERETELERMKERAKKAGAQRKEEEAERKqlqakLQQTEEELRS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1118 LRQQLDDAANKAESKDKTIVNIQDQFQdVLTRFQAESQRHSLRLEDRNQELVSecshLRERLCQYENEkaerevvVRQLQ 1197
Cdd:pfam07888 190 LSKEFQELRNSLAQRDTQVLQLQDTIT-TLTQKLTTAHRKEAENEALLEELRS----LQERLNASERK-------VEGLG 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1198 QELADTLKKQSMSEASLevssrYRSNLeeEARDLKKKLGQLRSQLQEAR---DQHREAVHH-AEKMEDHLQKLELEKSKF 1273
Cdd:pfam07888 258 EELSSMAAQRDRTQAEL-----HQARL--QAAQLTLQLADASLALREGRarwAQERETLQQsAEADKDRIEKLSAELQRL 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1274 EITIKKQSEEIDQLQENL------SRVNLSEEDKEklqkLTELKESLEctvdqeqkrssALEKElaefKEVLKMTKKELN 1347
Cdd:pfam07888 331 EERLQEERMEREKLEVELgrekdcNRVQLSESRRE----LQELKASLR-----------VAQKE----KEQLQAEKQELL 391
|
..
gi 124487433 1348 EY 1349
Cdd:pfam07888 392 EY 393
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
708-1380 |
7.80e-05 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 47.83 E-value: 7.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 708 KRLIELKRSHCELLTGKLKRMENKYKGlQKEMSETEEVKSRLEHEKVGWEQELCRLRFALKQEEEKRRSADQL---SEKT 784
Cdd:PTZ00121 1212 RKAEEARKAEDAKKAEAVKKAEEAKKD-AEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELkkaEEKK 1290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 785 SEQLRRKGEQCQSEVEARQQLEASLRTleMELKTVKSHLNQVLEERNETQRQLSREQNARMLQDGILASHLCKQKEIEMT 864
Cdd:PTZ00121 1291 KADEAKKAEEKKKADEAKKKAEEAKKA--DEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEA 1368
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 865 QKKMTSEVSVSHE---KEKDLLHKNQRLQDEVAVLRLEMDTIKSHNQEKE-----KRYLEDIKIANEKNDNLQRMVKLnE 936
Cdd:PTZ00121 1369 AEKKKEEAKKKADaakKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKkadeaKKKAEEKKKADEAKKKAEEAKKA-D 1447
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 937 ETFTKTIFQYTGQLNSLKAENTMLSSKLDN---EKQNKERLETDVESFRSRLASALHDHAEIQTAKRDLEIAFQRARDEW 1013
Cdd:PTZ00121 1448 EAKKKAEEAKKAEEAKKKAEEAKKADEAKKkaeEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEA 1527
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1014 FRVKDKMNFDmsNLRDNNEVL-SQQLSKTERKLNSLEI-EFHHTKDELREKTLALKHAQRDLSQTQCQMKEVEHMFQDEQ 1091
Cdd:PTZ00121 1528 KKAEEAKKAD--EAKKAEEKKkADELKKAEELKKAEEKkKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEK 1605
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1092 GKVSKFMGKQESIEERLAQLQSENTLLRQQLDDAANKAESKDKTivnIQDQFQDVLTRFQAESQRHSLRLEDRNQELVSE 1171
Cdd:PTZ00121 1606 KMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKA---EELKKAEEENKIKAAEEAKKAEEDKKKAEEAKK 1682
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1172 CSHLRERLCQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVSSRYRSNLEEEARDLKKKLGQLRSQLQEARD-QHR 1250
Cdd:PTZ00121 1683 AEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKiAHL 1762
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1251 EAVHHAEKMEDHLQKLELEKSKFEITIKKQSEEIDQLQENL--SRVNLSEEDKEKLQKLTELKESLECTVDQEQKRSSAL 1328
Cdd:PTZ00121 1763 KKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIfdNFANIIEGGKEGNLVINDSKEMEDSAIKEVADSKNMQ 1842
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|...
gi 124487433 1329 EKELAEFKEVLKMTKKELNEYENRELNLRQDIKN-NHLEMDIPVSTLIKKIDD 1380
Cdd:PTZ00121 1843 LEEADAFEKHKFNKNNENGEDGNKEADFNKEKDLkEDDEEEIEEADEIEKIDK 1895
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
147-178 |
1.73e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 40.35 E-value: 1.73e-04
10 20 30
....*....|....*....|....*....|...
gi 124487433 147 GNTALHYAVYSE-NTSMAAKLLAHNANIEAKNK 178
Cdd:pfam00023 2 GNTPLHLAAGRRgNLEIVKLLLSKGADVNARDK 34
|
|
| DR0291 |
COG1579 |
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ... |
1178-1339 |
1.79e-04 |
|
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain] Cd Length: 236 Bit Score: 44.92 E-value: 1.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1178 RLCQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVSSRYRSNLEEEARDLKKKLGQLRSQLQEARDQhREavhhAE 1257
Cdd:COG1579 18 ELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNN-KE----YE 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1258 KMEDHLQKLELEKSKFEITIKKQSEEIDQLQENLSRvnLSEEDKEKLQKLTELKESLECTVDQEQKRSSALEKELAEFKE 1337
Cdd:COG1579 93 ALQKEIESLKRRISDLEDEILELMERIEELEEELAE--LEAELAELEAELEEKKAELDEELAELEAELEELEAEREELAA 170
|
..
gi 124487433 1338 VL 1339
Cdd:COG1579 171 KI 172
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
1066-1252 |
1.95e-04 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 45.59 E-value: 1.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1066 LKHAQRDLSQTQCQMKEVEHMFQDEQGKVSKFMGKQESIEERLAQLQSENTLLRQQLDDAANKAESK----DKTIVNIQ- 1140
Cdd:COG3883 18 IQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERreelGERARALYr 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1141 --------------DQFQDVLTRFQAESqrhslRLEDRNQELVSECSHLRERLcqyENEKAEREVVVRQLQQELADTLKK 1206
Cdd:COG3883 98 sggsvsyldvllgsESFSDFLDRLSALS-----KIADADADLLEELKADKAEL---EAKKAELEAKLAELEALKAELEAA 169
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 124487433 1207 QSMSEASLEVSSRYRSNLEEEARDLKKKLGQLRSQLQEARDQHREA 1252
Cdd:COG3883 170 KAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAA 215
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
920-1340 |
2.08e-04 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 46.49 E-value: 2.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 920 IANEKNDNLQRMVKLNEETFTKTifqytGQLNSLKAENTMLSSKLDNEKQNKERLETDVESFRSRLASAlhdhaeiQTAK 999
Cdd:PRK04863 277 HANERRVHLEEALELRRELYTSR-----RQLAAEQYRLVEMARELAELNEAESDLEQDYQAASDHLNLV-------QTAL 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1000 RDLEiAFQRARDEWfrvkDKMNFdmsNLRDNNEVL---SQQLSKTERKLNSLEIEFHHTK----------DELREKTLAL 1066
Cdd:PRK04863 345 RQQE-KIERYQADL----EELEE---RLEEQNEVVeeaDEQQEENEARAEAAEEEVDELKsqladyqqalDVQQTRAIQY 416
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1067 KHAQRDL--SQTQCQMKEVEhmfqdeqgkvskfmgkQESIEERLAQLQSENTLLRQQLDDAANKAESKDktivNIQDQFQ 1144
Cdd:PRK04863 417 QQAVQALerAKQLCGLPDLT----------------ADNAEDWLEEFQAKEQEATEELLSLEQKLSVAQ----AAHSQFE 476
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1145 dvltrfQAESQRHSLRLE-DRNQELvsecSHLRERLCQYENEK--AEREVVVRQLQQELADTLKKQSMSEASL-EVSSRY 1220
Cdd:PRK04863 477 ------QAYQLVRKIAGEvSRSEAW----DVARELLRRLREQRhlAEQLQQLRMRLSELEQRLRQQQRAERLLaEFCKRL 546
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1221 RSNLEEEArDLKKKLGQLRSQLQEARDQHREAVHHAEKMEDHLQKLELEKSKFEitikKQSEEIDQLQENLSRVN-LSEE 1299
Cdd:PRK04863 547 GKNLDDED-ELEQLQEELEARLESLSESVSEARERRMALRQQLEQLQARIQRLA----ARAPAWLAAQDALARLReQSGE 621
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 124487433 1300 DKEKLQKLTELKESLectvdQEQKRSSALEK-ELAEFKEVLK 1340
Cdd:PRK04863 622 EFEDSQDVTEYMQQL-----LERERELTVERdELAARKQALD 658
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
877-1337 |
2.15e-04 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 45.91 E-value: 2.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 877 EKEKDLLHKNQRLQDEVAVLRLEMDTIKSHN-QEKEKRYLEDIKIANEKNDNLQRmVKLNEETFTKTIFQYTGQLNSLKA 955
Cdd:COG4717 52 EKEADELFKPQGRKPELNLKELKELEEELKEaEEKEEEYAELQEELEELEEELEE-LEAELEELREELEKLEKLLQLLPL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 956 ENTM--LSSKLDNEKQNKERLETDVESFRSRLASALHDHAEIQTAKRDLEIAFQRARDEWFRvkdkmnfDMSNLRDNNEV 1033
Cdd:COG4717 131 YQELeaLEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEE-------ELQDLAEELEE 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1034 LSQQLSKTERKLNSLEIEFHHTKDELR--EKTLALKHAQRDLSQTQCQMK------EVEHMFQDEQGKVSKFMGKQESIE 1105
Cdd:COG4717 204 LQQRLAELEEELEEAQEELEELEEELEqlENELEAAALEERLKEARLLLLiaaallALLGLGGSLLSLILTIAGVLFLVL 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1106 ERLAQLQSENTLLRQQLDDAANKAESKDKTIVNIQDQFQDVLTRFQAEsqrhslrlEDRNQELVSECSHLRERLCQYENE 1185
Cdd:COG4717 284 GLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLP--------PDLSPEELLELLDRIEELQELLRE 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1186 KAEREvvvRQLQQELADTLKKQSMSEASLEVSSRYRSNLE--EEARDLKKKLGQLRSQLQEARD--QHREAVHHAEKMED 1261
Cdd:COG4717 356 AEELE---EELQLEELEQEIAALLAEAGVEDEEELRAALEqaEEYQELKEELEELEEQLEELLGelEELLEALDEEELEE 432
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124487433 1262 HLQKLELEKSKFEITIKKQSEEIDQLQENLSRVNLSEEDKEKLQKLTELKESLECTVDQEQKRSSA---LEKELAEFKE 1337
Cdd:COG4717 433 ELEELEEELEELEEELEELREELAELEAELEQLEEDGELAELLQELEELKAELRELAEEWAALKLAlelLEEAREEYRE 511
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
82-109 |
3.60e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 39.16 E-value: 3.60e-04
10 20
....*....|....*....|....*...
gi 124487433 82 RTALHLACAYGHPEVVTLLVERKCEIDA 109
Cdd:pfam13606 3 NTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
1057-1248 |
4.07e-04 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 45.33 E-value: 4.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1057 DELREKTLALKHAQRDLSQTQCQMKEV----EHM-FQDEQGKVSKFMGKQESIEERLAQLQSENTLLRQQLDDAANKAES 1131
Cdd:PRK04863 938 EQLKQDYQQAQQTQRDAKQQAFALTEVvqrrAHFsYEDAAEMLAKNSDLNEKLRQRLEQAEQERTRAREQLRQAQAQLAQ 1017
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1132 KDKTivniqdqFQDVLTRFQAESQRHslrledrnQELVSECSHLRERLCQYENEKAerevvvRQLQQELADTLKKQSMSE 1211
Cdd:PRK04863 1018 YNQV-------LASLKSSYDAKRQML--------QELKQELQDLGVPADSGAEERA------RARRDELHARLSANRSRR 1076
|
170 180 190
....*....|....*....|....*....|....*..
gi 124487433 1212 ASLEvssRYRSNLEEEARDLKKKLGQLRSQLQEARDQ 1248
Cdd:PRK04863 1077 NQLE---KQLTFCEAEMDNLTKKLRKLERDYHEMREQ 1110
|
|
| Myosin_tail_1 |
pfam01576 |
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ... |
721-1315 |
4.14e-04 |
|
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
Pssm-ID: 460256 [Multi-domain] Cd Length: 1081 Bit Score: 45.17 E-value: 4.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 721 LTGKLKRMENKYKGLQKEMSETEEVKSRLEHEKVGWEQELCRLRFALKQE-------EEKRRSADQLSEKTSEQLRRKGE 793
Cdd:pfam01576 487 LSTRLRQLEDERNSLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKLEEDagtlealEEGKKRLQRELEALTQQLEEKAA 566
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 794 QCQSEVEARQQLEASLRTLEMELKTVKSHLNQVLEERNETQRQLSREQN--ARMLQDGILASHLCKQKEiemtqkkmTSE 871
Cdd:pfam01576 567 AYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQMLAEEKAisARYAEERDRAEAEAREKE--------TRA 638
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 872 VSVSHEKEKDLLHKNQrLQDEVAVLRLEMDTIKS---------HNQEKEKRYLEdiKIANEKNDNLQRMV-KLNEETFTK 941
Cdd:pfam01576 639 LSLARALEEALEAKEE-LERTNKQLRAEMEDLVSskddvgknvHELERSKRALE--QQVEEMKTQLEELEdELQATEDAK 715
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 942 TIFQYTGQlnSLKAENTMLSSKLDNEKQNKER--------LETDVESFRSRLASALHDHAEIQTAKRDLEI---AFQRAR 1010
Cdd:pfam01576 716 LRLEVNMQ--ALKAQFERDLQARDEQGEEKRRqlvkqvreLEAELEDERKQRAQAVAAKKKLELDLKELEAqidAANKGR 793
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1011 DEWFRVKDKMNFDMSNL-------RDNNEVLSQQLSKTERKLNSLEIEFHHTKDELREKTLALKHAQRDLSQTQcqmkev 1083
Cdd:pfam01576 794 EEAVKQLKKLQAQMKDLqreleeaRASRDEILAQSKESEKKLKNLEAELLQLQEDLAASERARRQAQQERDELA------ 867
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1084 EHMFQDEQGKVSKFMGKQEsIEERLAQLQSEntllrqqLDDAANKAESKDKTIVNIQDQFQDVLTRFQAEsQRHSLRLED 1163
Cdd:pfam01576 868 DEIASGASGKSALQDEKRR-LEARIAQLEEE-------LEEEQSNTELLNDRLRKSTLQVEQLTTELAAE-RSTSQKSES 938
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1164 RNQELVSECSHLRERLcqyenekAEREVVVRQLQQELADTLK-KQSMSEASLEVSSRYRSNLEEEARDLKKKLGQLRSQL 1242
Cdd:pfam01576 939 ARQQLERQNKELKAKL-------QEMEGTVKSKFKSSIAALEaKIAQLEEQLEQESRERQAANKLVRRTEKKLKEVLLQV 1011
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124487433 1243 QEARdqhreavHHAEKMEDHLQKLELEKSKfeitIKKQSEEIdqlQENLSRVNLSeedKEKLQK-LTELKESLE 1315
Cdd:pfam01576 1012 EDER-------RHADQYKDQAEKGNSRMKQ----LKRQLEEA---EEEASRANAA---RRKLQReLDDATESNE 1068
|
|
| ClpA |
COG0542 |
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ... |
1215-1348 |
4.26e-04 |
|
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440308 [Multi-domain] Cd Length: 836 Bit Score: 45.07 E-value: 4.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1215 EVSSRYR---SNLEEEARDLKKKLGQLRSQLQEA-RDQHREAVHHAEKMEDHLQKLElekskfeitikkqsEEIDQLQEN 1290
Cdd:COG0542 397 EAAARVRmeiDSKPEELDELERRLEQLEIEKEALkKEQDEASFERLAELRDELAELE--------------EELEALKAR 462
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 124487433 1291 LsrvnlsEEDKEKLQKLTELKESLEctvdQEQKRSSALEKELAEFKEVLKMTKKELNE 1348
Cdd:COG0542 463 W------EAEKELIEEIQELKEELE----QRYGKIPELEKELAELEEELAELAPLLRE 510
|
|
| GumC |
COG3206 |
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis]; |
993-1246 |
4.27e-04 |
|
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442439 [Multi-domain] Cd Length: 687 Bit Score: 45.01 E-value: 4.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 993 AEIQTAKRDLEIAFQRARDewFRVKDkmnfDMSNLRDNNEVLSQQLSKTERKLNSLEIEfhhtkdeLREKTLALKHAQRD 1072
Cdd:COG3206 182 EQLPELRKELEEAEAALEE--FRQKN----GLVDLSEEAKLLLQQLSELESQLAEARAE-------LAEAEARLAALRAQ 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1073 LSQTQCQMKEVehmfqdeqgkvskfmgkqeSIEERLAQLQSENTLLRQQLDDAANKAESKDKTIVNIQDQFQDVLTRFQA 1152
Cdd:COG3206 249 LGSGPDALPEL-------------------LQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQ 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1153 ESQRhslrledrnqelvsecshlreRLCQYENEKAEREVVVRQLQQELADtLKKQSMSEASLEVssRYRsNLEEEARDLK 1232
Cdd:COG3206 310 EAQR---------------------ILASLEAELEALQAREASLQAQLAQ-LEARLAELPELEA--ELR-RLEREVEVAR 364
|
250
....*....|....
gi 124487433 1233 KKLGQLRSQLQEAR 1246
Cdd:COG3206 365 ELYESLLQRLEEAR 378
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
1065-1272 |
4.31e-04 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 44.75 E-value: 4.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1065 ALKHAQRDLSQTQCQMKEVEHMFQDEQGKVSKFMGKQESIEERLAQ-------LQSENTLLRQQLDDAANKAESKDKTIV 1137
Cdd:COG4942 21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAAlarriraLEQELAALEAELAELEKEIAELRAELE 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1138 NIQDQFQDVLTRFQAESQRHSLRL----ED-----RNQELVSECS-HLRERLCQYENEKAEREVVVRQLQQE---LADTL 1204
Cdd:COG4942 101 AQKEELAELLRALYRLGRQPPLALllspEDfldavRRLQYLKYLApARREQAEELRADLAELAALRAELEAEraeLEALL 180
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 124487433 1205 KKQsmseaslevsSRYRSNLEEEARDLKKKLGQLRSQLQEARDQHREAVHHAEKMEDHLQKLELEKSK 1272
Cdd:COG4942 181 AEL----------EEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAA 238
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
80-109 |
5.42e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 38.72 E-value: 5.42e-04
10 20 30
....*....|....*....|....*....|
gi 124487433 80 KDRTALHLACAYGHPEVVTLLVERKCEIDA 109
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| COG4913 |
COG4913 |
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown]; |
1036-1554 |
5.54e-04 |
|
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain] Cd Length: 1089 Bit Score: 44.91 E-value: 5.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1036 QQLSKTERKLNSLEiefhhtkdELREKTLALKHAQRDLSQTQcQMKEVEHMFQDEQgKVSKFMGKQESIEERLAQLQSEN 1115
Cdd:COG4913 242 EALEDAREQIELLE--------PIRELAERYAAARERLAELE-YLRAALRLWFAQR-RLELLEAELEELRAELARLEAEL 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1116 TLLRQQLDDAAnkaESKDKTIVNIQDQFQDVLTRFQAESQRHSLRLEDRNQElvsecshlRERLcqyenekaerEVVVRQ 1195
Cdd:COG4913 312 ERLEARLDALR---EELDELEAQIRGNGGDRLEQLEREIERLERELEERERR--------RARL----------EALLAA 370
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1196 LQQELADT----LKKQSMSEASLEVSSRYRSNLEEEARDLKKKLGQLRSQLQEARDQHREAVHHAEKMEDHLQKL----- 1266
Cdd:COG4913 371 LGLPLPASaeefAALRAEAAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALrdala 450
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1267 -ELEKSKFE-------ITIKKQSEE----------------------IDQLQENLSRVNLS--------EEDKEKLQKLT 1308
Cdd:COG4913 451 eALGLDEAElpfvgelIEVRPEEERwrgaiervlggfaltllvppehYAAALRWVNRLHLRgrlvyervRTGLPDPERPR 530
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1309 ELKESLECTVD-QEQKRSSALEKELAEFKEVLK------------------MTKkelNEYENRELNLRQDIKNNHLemdI 1369
Cdd:COG4913 531 LDPDSLAGKLDfKPHPFRAWLEAELGRRFDYVCvdspeelrrhpraitragQVK---GNGTRHEKDDRRRIRSRYV---L 604
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1370 PVSTlIKKIDDLTAKLETASSKCLHLGKKNQLLQQELLLMRTIQKKCGKL------EKNKKQLEQEVVNL---RSHMEKN 1440
Cdd:COG4913 605 GFDN-RAKLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLaeyswdEIDVASAEREIAELeaeLERLDAS 683
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1441 MVEHSQAQQYAREVEERaRQDLVEKLKQVNLFLQAQAASQESLEQLRENSNASVRSQMELRIKDLESQLYRMKAQEDFDK 1520
Cdd:COG4913 684 SDDLAALEEQLEELEAE-LEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAALGDA 762
|
570 580 590
....*....|....*....|....*....|....
gi 124487433 1521 IELEKYKQLYQEefraRKSLSSKLNKTSEKLEEA 1554
Cdd:COG4913 763 VERELRENLEER----IDALRARLNRAEEELERA 792
|
|
| DUF5401 |
pfam17380 |
Family of unknown function (DUF5401); This is a family of unknown function found in ... |
773-1167 |
6.54e-04 |
|
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 44.34 E-value: 6.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 773 KRRSADQLSEKTSEQLRRKGEQCQSEVEARQQLEASLRTLEMELK---TVKSHLNQVLEERNETQRQLSREQNARMLQDg 849
Cdd:pfam17380 286 ERQQQEKFEKMEQERLRQEKEEKAREVERRRKLEEAEKARQAEMDrqaAIYAEQERMAMERERELERIRQEERKRELER- 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 850 ilashlCKQKEIEMTQKKMTSEVSVSHEKEKdllhKNQRLQDEVAVLRLEMDTIKSHNQEKEKRYLEDIKIANEKNDNLQ 929
Cdd:pfam17380 365 ------IRQEEIAMEISRMRELERLQMERQQ----KNERVRQELEAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQ 434
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 930 RMVKLNEETFTKTIFQYtgQLNSLKAENTMLSSKLDNEKQNKERLETDVESfrsrlasalHDHAEIQTAKRDLeiafqra 1009
Cdd:pfam17380 435 REVRRLEEERAREMERV--RLEEQERQQQVERLRQQEEERKRKKLELEKEK---------RDRKRAEEQRRKI------- 496
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1010 rdewfrvkdkmnfdmsnLRDNNEVLSQQLSKTERKLNSLEIEFhhtkdELREKTLALKHAQRDLSQTQCQMKEVEhmfqd 1089
Cdd:pfam17380 497 -----------------LEKELEERKQAMIEEERKRKLLEKEM-----EERQKAIYEEERRREAEEERRKQQEME----- 549
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1090 EQGKVSKFMGKQESIEERLAQLQSENTLLRQQLDDAANKAESKDKT-IVNIQDQFQDVLTRFQ-AESQRHSLRLEDRNQE 1167
Cdd:pfam17380 550 ERRRIQEQMRKATEERSRLEAMEREREMMRQIVESEKARAEYEATTpITTIKPIYRPRISEYQpPDVESHMIRFTTQSPE 629
|
|
| EzrA |
pfam06160 |
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ... |
1035-1309 |
6.92e-04 |
|
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation. The structure contains 5 spectrin like alpha helical repeats.
Pssm-ID: 428797 [Multi-domain] Cd Length: 542 Bit Score: 44.07 E-value: 6.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1035 SQQLSKTERKLNSLEIEFHHTKDELREKTLALKHAQRDLSQTQCQMKEVEHMFQDEQgkvskFMGKQESIEERLAQlqSE 1114
Cdd:pfam06160 178 REVLEKLEEETDALEELMEDIPPLYEELKTELPDQLEELKEGYREMEEEGYALEHLN-----VDKEIQQLEEQLEE--NL 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1115 NTLLRQQLDDAANKAESKDKTIVNIQDQF-------QDVLTRfQAESQRHSLRLEDRNQELVSECSHLR----------E 1177
Cdd:pfam06160 251 ALLENLELDEAEEALEEIEERIDQLYDLLekevdakKYVEKN-LPEIEDYLEHAEEQNKELKEELERVQqsytlnenelE 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1178 RLCQYENEKAEREVVVRQLQQELADtlKKQSMSEASLEVSSRYRS--NLEEEARDLKKKLGQLRSQLQEARDQhreavhh 1255
Cdd:pfam06160 330 RVRGLEKQLEELEKRYDEIVERLEE--KEVAYSELQEELEEILEQleEIEEEQEEFKESLQSLRKDELEAREK------- 400
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 124487433 1256 AEKMEDHLQ--KLELEKSK-------FEITIKKQSEEIDQLQENLSR-----------VNLSEEDKEKLQKLTE 1309
Cdd:pfam06160 401 LDEFKLELReiKRLVEKSNlpglpesYLDYFFDVSDEIEDLADELNEvplnmdevnrlLDEAQDDVDTLYEKTE 474
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
985-1248 |
7.70e-04 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 43.98 E-value: 7.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 985 LASALHDHAEIQTAKRDLEiAFQRARDEWFRVKDKMNFDMSNLRDNNEVLSQQLSKTERKLNSLEIEFHHTKDELREKTL 1064
Cdd:COG4942 12 ALAAAAQADAAAEAEAELE-QLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEK 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1065 ALKHAQRDLSQTQCQMKevehmfqdEQGKVSKFMGKQESIEERLAQLQSENTLLRQQLDDAANKAeskdktivnIQDQFQ 1144
Cdd:COG4942 91 EIAELRAELEAQKEELA--------ELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPA---------RREQAE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1145 DvLTRFQAESQRHSLRLEDRNQELVSECSHLRERLCQYENEKAEREVVVRQLQQELADTLKKQsmseaslevssryrSNL 1224
Cdd:COG4942 154 E-LRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAEL--------------AEL 218
|
250 260
....*....|....*....|....
gi 124487433 1225 EEEARDLKKKLGQLRSQLQEARDQ 1248
Cdd:COG4942 219 QQEAEELEALIARLEAEAAAAAER 242
|
|
| PLN02939 |
PLN02939 |
transferase, transferring glycosyl groups |
1227-1510 |
8.04e-04 |
|
transferase, transferring glycosyl groups
Pssm-ID: 215507 [Multi-domain] Cd Length: 977 Bit Score: 44.51 E-value: 8.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1227 EARDLKKKLGQLRSQLQEARDQHREAVH---HAEKMEDHLQKLELEKSKFEIT----IKKQSEEIDQLQ-ENLSRVNLSE 1298
Cdd:PLN02939 164 EKEALQGKINILEMRLSETDARIKLAAQekiHVEILEEQLEKLRNELLIRGATeglcVHSLSKELDVLKeENMLLKDDIQ 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1299 EDKEKLQKLTELKESLectvdqeqkrsSALEKELAEFKEVLKmtkkelnEYENRELNLRQDI-KNNHLEMDIpvstLIKK 1377
Cdd:PLN02939 244 FLKAELIEVAETEERV-----------FKLEKERSLLDASLR-------ELESKFIVAQEDVsKLSPLQYDC----WWEK 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1378 IDDLTAKLETASSKCLHlgkknqlLQQELLLMRTIQKKCGKLEKNKKqlEQEVVNLRSHMEKNMvehsqaQQYAREVEER 1457
Cdd:PLN02939 302 VENLQDLLDRATNQVEK-------AALVLDQNQDLRDKVDKLEASLK--EANVSKFSSYKVELL------QQKLKLLEER 366
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 124487433 1458 ARQDLVEKLKQVNLFLQAQAASQESLEQLRENSNasvRSQMELRIKDLESQLY 1510
Cdd:PLN02939 367 LQASDHEIHSYIQLYQESIKEFQDTLSKLKEESK---KRSLEHPADDMPSEFW 416
|
|
| CwlO1 |
COG3883 |
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ... |
1100-1334 |
8.28e-04 |
|
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];
Pssm-ID: 443091 [Multi-domain] Cd Length: 379 Bit Score: 43.67 E-value: 8.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1100 KQESIEERLAQLQSENTLLRQQLDDAANKAESKDKTIVNIQDQfqdvLTRFQAESQRHSLRLEDRNQELVSECSHLRERL 1179
Cdd:COG3883 17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAE----LEALQAEIDKLQAEIAEAEAEIEERREELGERA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1180 -CQYENEKAEREVVVRQLQQELADTLKKQSMseasLEVSSRYRSNLEEEARDLKKKLGQLRSQLQEARDQHREAvhhAEK 1258
Cdd:COG3883 93 rALYRSGGSVSYLDVLLGSESFSDFLDRLSA----LSKIADADADLLEELKADKAELEAKKAELEAKLAELEAL---KAE 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 124487433 1259 MEDHLQKLELEKSKFEITIKKQSEEIDQLQENLSRvnLSEEDKEKLQKLTELKESLECTVDQEQKRSSALEKELAE 1334
Cdd:COG3883 166 LEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAE--LEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 239
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
778-1270 |
9.15e-04 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 43.99 E-value: 9.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 778 DQLSEKTSEQLRRKGEQCQSEVEARQQLEASLRtlemELKTVKSHLNQVLEERNETQRQLSREQNARmlqdgilashlcK 857
Cdd:COG4717 49 ERLEKEADELFKPQGRKPELNLKELKELEEELK----EAEEKEEEYAELQEELEELEEELEELEAEL------------E 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 858 QKEIEMTQKKMTSEVSVSHEKEKDLLHKNQRLQDEVAVLRLEMDTIKsHNQEKEKRYLEDIKIANEKNDNLQRMVKLNEE 937
Cdd:COG4717 113 ELREELEKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELR-ELEEELEELEAELAELQEELEELLEQLSLATE 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 938 tftKTIFQYTGQLNSLKAENTMLSSKLDNEKQNKERLETDVESFRSRLASAlHDHAEIQTAKRDLEIAFQRA--RDEWFR 1015
Cdd:COG4717 192 ---EELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAA-ALEERLKEARLLLLIAAALLalLGLGGS 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1016 VKDKMNFDMSNLRDNNEVLSQQLSKTERKLNSLEIEFHHTKDELREKTLALKHAQRDLSQTQCQMKEVEHMFQDEQGKVS 1095
Cdd:COG4717 268 LLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIE 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1096 KFMGKQESIEERLAQLQSENTLLRQQLDDAANKAESKDK--TIVNIQDQFQDVLTRF-QAESQRHSLRLEDRNQELVSEC 1172
Cdd:COG4717 348 ELQELLREAEELEEELQLEELEQEIAALLAEAGVEDEEElrAALEQAEEYQELKEELeELEEQLEELLGELEELLEALDE 427
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1173 SHLRERLCQYENEKAEREVVVRQLQQELADTlkKQSMSEASlevssryrsnLEEEARDLKKKLGQLRSQLQEARDQHREA 1252
Cdd:COG4717 428 EELEEELEELEEELEELEEELEELREELAEL--EAELEQLE----------EDGELAELLQELEELKAELRELAEEWAAL 495
|
490
....*....|....*...
gi 124487433 1253 VHHAEKMEDHLQKLELEK 1270
Cdd:COG4717 496 KLALELLEEAREEYREER 513
|
|
| TMCO5 |
pfam14992 |
TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing ... |
1225-1309 |
1.09e-03 |
|
TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing proteins 5A and 5B.
Pssm-ID: 464427 [Multi-domain] Cd Length: 278 Bit Score: 42.78 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1225 EEEARDLKKKLGQLRSqlqEARDQHREAVHHAE-KMEDHLQKLELEKSKFEITIKKQSEEIDQLQENLSR---------- 1293
Cdd:pfam14992 30 EEEIQSLEREITLTRS---LAEDEEREELNFTImEKEDALQELELETAKLEKKNEILVKSVMELQRKLSRksdkntgleq 106
|
90
....*....|....*....
gi 124487433 1294 ---VNLSEEDKEKLQKLTE 1309
Cdd:pfam14992 107 etlKQMLEELKVKLQQSEE 125
|
|
| DUF5401 |
pfam17380 |
Family of unknown function (DUF5401); This is a family of unknown function found in ... |
1101-1351 |
1.21e-03 |
|
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
Pssm-ID: 375164 [Multi-domain] Cd Length: 722 Bit Score: 43.57 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1101 QESIEERLAQ---LQSENTLLRQQLDDAANKAESKDKtIVNIQDQFQDVLTRFQAESQRHSLRLEDRNQELvsecSHLRE 1177
Cdd:pfam17380 281 QKAVSERQQQekfEKMEQERLRQEKEEKAREVERRRK-LEEAEKARQAEMDRQAAIYAEQERMAMEREREL----ERIRQ 355
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1178 RLCQYENEKAEREVV------VRQLQQELADTLKKQSMSEASLEVSSRYRsnLEEEARdlKKKLGQLRSQLQEARDQHRE 1251
Cdd:pfam17380 356 EERKRELERIRQEEIameisrMRELERLQMERQQKNERVRQELEAARKVK--ILEEER--QRKIQQQKVEMEQIRAEQEE 431
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1252 AvhhaekMEDHLQKLELEKSKfeiTIKKQSEEIDQLQENLSRVNLSEEDKEKlQKLTELKESLECTVDQEQKRsSALEKE 1331
Cdd:pfam17380 432 A------RQREVRRLEEERAR---EMERVRLEEQERQQQVERLRQQEEERKR-KKLELEKEKRDRKRAEEQRR-KILEKE 500
|
250 260
....*....|....*....|....*..
gi 124487433 1332 LAEFKEVL-------KMTKKELNEYEN 1351
Cdd:pfam17380 501 LEERKQAMieeerkrKLLEKEMEERQK 527
|
|
| DUF4686 |
pfam15742 |
Domain of unknown function (DUF4686); This family of proteins is found in eukaryotes. Proteins ... |
1159-1348 |
1.23e-03 |
|
Domain of unknown function (DUF4686); This family of proteins is found in eukaryotes. Proteins in this family are typically between 498 and 775 amino acids in length. There is a conserved DLK sequence motif.
Pssm-ID: 464838 [Multi-domain] Cd Length: 384 Bit Score: 43.13 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1159 LRLED-RNQELVSECSHLRERLCQYENEKAEREVVVRQLQQELadtlkKQSMSEASLEVSSRYRSNLEEEARDLKKKLGQ 1237
Cdd:pfam15742 95 LELEVlKQAQSIKSQNSLQEKLAQEKSRVADAEEKILELQQKL-----EHAHKVCLTDTCILEKKQLEERIKEASENEAK 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1238 LRSQLQEARDQHREAVHHAEKMEDHLQKLELEKSKFEITIKKQSEEIDQLQENLSRV----NLSEEDKEKLQKLTELKES 1313
Cdd:pfam15742 170 LKQQYQEEQQKRKLLDQNVNELQQQVRSLQDKEAQLEMTNSQQQLRIQQQEAQLKQLenekRKSDEHLKSNQELSEKLSS 249
|
170 180 190
....*....|....*....|....*....|....*
gi 124487433 1314 LectvdqeQKRSSALEKELAEFKEVLKMTKKELNE 1348
Cdd:pfam15742 250 L-------QQEKEALQEELQQVLKQLDVHVRKYNE 277
|
|
| TRPV1-4 |
cd22193 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ... |
83-207 |
1.37e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.
Pssm-ID: 411977 [Multi-domain] Cd Length: 607 Bit Score: 43.25 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 83 TALHLACAYGHPEVVTLLVE---RKCEIDARDSESSTALIKAVQCQEeecaailldhgadpnvmDSSGNTALHYAVYSEN 159
Cdd:cd22193 125 LPLSLAACTNQPDIVQYLLEnehQPADIEAQDSRGNTVLHALVTVAD-----------------NTKENTKFVTRMYDMI 187
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 124487433 160 TSMAAKLLAHNANIEAKNKDDLTPMLLAVKENK----QHIVEFLVKKKASIH 207
Cdd:cd22193 188 LIRGAKLCPTVELEEIRNNDGLTPLQLAAKMGKieilKYILQREIKEPELRH 239
|
|
| HEC1 |
COG5185 |
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ... |
1223-1501 |
1.39e-03 |
|
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444066 [Multi-domain] Cd Length: 594 Bit Score: 43.41 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1223 NLEEEARDLKKKLGQLRSQLQEARDQhREAVHHAEKMEDHLQKLELE------KSKFEITIKKQSEEIDQLQ-------- 1288
Cdd:COG5185 279 RLNENANNLIKQFENTKEKIAEYTKS-IDIKKATESLEEQLAAAEAEqeleesKRETETGIQNLTAEIEQGQesltenle 357
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1289 ---ENLSRVNLSEEDKEKLQKLTELKESLECTVDQ-EQKRSSALEKElaefKEVLKMTKKELNEYENRELNLRQDIKNNH 1364
Cdd:COG5185 358 aikEEIENIVGEVELSKSSEELDSFKDTIESTKESlDEIPQNQRGYA----QEILATLEDTLKAADRQIEELQRQIEQAT 433
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1365 LEMDIPVSTLIKKIDDLTAKLETASSKclhlgKKNQLLQQELLLMRTIQKKCGKLEKNKKQLEQEVVNLRSHMEKNMVEH 1444
Cdd:COG5185 434 SSNEEVSKLLNELISELNKVMREADEE-----SQSRLEEAYDEINRSVRSKKEDLNEELTQIESRVSTLKATLEKLRAKL 508
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 124487433 1445 SQAQQYAREVEERARQDLVEKLKQVNLFLQAQAASQESLEQLRENSNASVRSQMELR 1501
Cdd:COG5185 509 ERQLEGVRSKLDQVAESLKDFMRARGYAHILALENLIPASELIQASNAKTDGQAANL 565
|
|
| PRK04778 |
PRK04778 |
septation ring formation regulator EzrA; Provisional |
1028-1359 |
1.41e-03 |
|
septation ring formation regulator EzrA; Provisional
Pssm-ID: 179877 [Multi-domain] Cd Length: 569 Bit Score: 43.29 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1028 RDNNEVLSQQLSKTERKLNSLEiefhhtkDELRekTLALKHAQRDLSQTQCQMKEVEHMFQDEQGKVSKFMGKQESIEER 1107
Cdd:PRK04778 71 QKWDEIVTNSLPDIEEQLFEAE-------ELND--KFRFRKAKHEINEIESLLDLIEEDIEQILEELQELLESEEKNREE 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1108 LAQL-----QSENTLL--RQQLDDAANKAESKdktIVNIQDQFQDVLTRFQA----ESQRHSLRLEDRNQELvsecSHLR 1176
Cdd:PRK04778 142 VEQLkdlyrELRKSLLanRFSFGPALDELEKQ---LENLEEEFSQFVELTESgdyvEAREILDQLEEELAAL----EQIM 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1177 ERLCQyenekaerevVVRQLQQELADTLKKQSMSEASLEVSSRY--RSNLEEEARDLKKKLGQLRSQLQEAR-DQHREAV 1253
Cdd:PRK04778 215 EEIPE----------LLKELQTELPDQLQELKAGYRELVEEGYHldHLDIEKEIQDLKEQIDENLALLEELDlDEAEEKN 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1254 HHAEKMEDHL-----------QKLELEKSKFEITIKKQSEEIDQLQENLSRVN----LSEEDKEKLQKLTELKESLECTV 1318
Cdd:PRK04778 285 EEIQERIDQLydilerevkarKYVEKNSDTLPDFLEHAKEQNKELKEEIDRVKqsytLNESELESVRQLEKQLESLEKQY 364
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 124487433 1319 DQEQKRS-------SALEKELAEFKEVLKMTKKELNEYENRELNLRQD 1359
Cdd:PRK04778 365 DEITERIaeqeiaySELQEELEEILKQLEEIEKEQEKLSEMLQGLRKD 412
|
|
| NIP100 |
COG5244 |
Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle ... |
774-1385 |
1.75e-03 |
|
Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 227569 [Multi-domain] Cd Length: 669 Bit Score: 43.14 E-value: 1.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 774 RRSADQLSEKTSEQLRRKGEQCQSEVEARQQLEASLRTLEMELKTVKSHLNQVLE--ERNETQRQLSREQNARMLQDGIL 851
Cdd:COG5244 65 RPDDDSLLNGNAAYEKIKGGLVCESKGMDKDGEIKQENHEDRIHFEESKIRRLEEtiEALKSTEKEEIVELRRENEELDK 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 852 ASHLCKQKEIEMTQKKMTSEVSVSHEKEKDLLHKNQRLQDEVAVLRLEMDTIKSHNQEKEKRYLedikiANEKNDNLQRM 931
Cdd:COG5244 145 INLSLRERISSEEPELNKDGSKLSYDELKEFVEESRVQVYDMVELVSDISETLNRNGSIQRSSV-----RECERSNIHDV 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 932 VKLNEETFTKTIFQYTGQLNSLKAENTMLSSKLDNEKQNKERLETDVESFRSrlasalhdhaeiqtakrdLEIAFQRARD 1011
Cdd:COG5244 220 LFLVNGILDGVIDELNGELERLRRQLVSLMSSHGIEVEENSRLKATLEKFQS------------------LELKVNTLQE 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1012 EWFRVKDKMNFDMSNLRDNNEVLSQQLSKTERKLNS-----LE-IEFHHTKDELREKTLALK------HAQRDLSQTQCQ 1079
Cdd:COG5244 282 ELYQNKLLKKFYQIYEPFAQAALSSQLQYLAEVIESenfgkLEnIEIHIILKVLSSISYALHiytiknTPDHLETTLQCF 361
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1080 MKEVEHMFQDEQGKVSKFMGKQESIEERLAQLQSENT------LLRQQLDDAANKAESKDKTIVNIQD------------ 1141
Cdd:COG5244 362 VNIAPISMWLSEFLQRKFSSKQETAFSICQFLEDNKDvtlilkILHPILETTVPKLLAFLRTNSNFNDndtlcligslye 441
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1142 -QFQDVLTRFQAESQRHSlRLEDRNQELVSECSHLR-------ERLCQYeNEKAEREVVVRQLQQELADTLKKQSMSEAS 1213
Cdd:COG5244 442 iARIDKLIGKEEISKQDN-RLFLYPSCDITLSSILTilfsdklEVFFQG-IESLLENITIFPEQPSQQTSDSENIKENSL 519
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1214 LevssryRSNLEEEARDLKKKLGQLRSQLQEardqhreavhhaEKMEDHLQKLELEKSKFEITIKKQSEEIdqlqeNLSR 1293
Cdd:COG5244 520 L------SDRLNEENIRLKEVLVQKENMLTE------------ETKIKIIIGRDLERKTLEENIKTLKVEL-----NNKN 576
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1294 VNLSEEDKEKLQKLTELKESLECTVDQ--EQKRSSALEKELAEFKEVLKMTKKELNEyENRELNLRQDIKNNHLEMDIPV 1371
Cdd:COG5244 577 NKLKEENFNLVNRLKNMELKLYQIKDNntLNKIYLDLVSEIMELRETIRRQIKEQKR-VSIDFSWLDELKQPFKEHIIEM 655
|
650
....*....|....
gi 124487433 1372 STLIKKIDDLTAKL 1385
Cdd:COG5244 656 FNFVSTSRILDLKL 669
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
1036-1200 |
2.01e-03 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 43.02 E-value: 2.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1036 QQLSKTERKLNSLEIEFHHtKDELREKTLALKHAQRDLSQTQCQMKEV----EHM-FQDEQGKVSKFMGKQESIEERLAQ 1110
Cdd:COG3096 917 KALAQLEPLVAVLQSDPEQ-FEQLQADYLQAKEQQRRLKQQIFALSEVvqrrPHFsYEDAVGLLGENSDLNEKLRARLEQ 995
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1111 LQSENTLLRQQLDDAANKAESKDKTIVNIQDQF---QDVLTRFQAESQRHSLRL--------EDRNQELVSECSHLRERL 1179
Cdd:COG3096 996 AEEARREAREQLRQAQAQYSQYNQVLASLKSSRdakQQTLQELEQELEELGVQAdaeaeeraRIRRDELHEELSQNRSRR 1075
|
170 180
....*....|....*....|.
gi 124487433 1180 CQYENEKAEREVVVRQLQQEL 1200
Cdd:COG3096 1076 SQLEKQLTRCEAEMDSLQKRL 1096
|
|
| 235kDa-fam |
TIGR01612 |
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ... |
711-1320 |
2.35e-03 |
|
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.
Pssm-ID: 130673 [Multi-domain] Cd Length: 2757 Bit Score: 43.12 E-value: 2.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 711 IELKRSHCELLTGKLKRMENKYKGLQKEMSETEEVKSRLEHEK---VGWEQELCRLrFALKQEEEKRRSADQLSE----- 782
Cdd:TIGR01612 1171 IEKKIENIVTKIDKKKNIYDEIKKLLNEIAEIEKDKTSLEEVKginLSYGKNLGKL-FLEKIDEEKKKSEHMIKAmeayi 1249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 783 KTSEQLRRKGEQCQSEVEARQQLEASLRTLEMELKTVKSHlnQVLEERNETQRQLSREQNARMLQDgilashLCKQKEIE 862
Cdd:TIGR01612 1250 EDLDEIKEKSPEIENEMGIEMDIKAEMETFNISHDDDKDH--HIISKKHDENISDIREKSLKIIED------FSEESDIN 1321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 863 MTQKKMTSEVSVSHEKEKDLlhkNQRLqDEVAVLR--LEMDTIKSHnQEKEKRYLEDIKianEKNDNLQRMVKlNEETFT 940
Cdd:TIGR01612 1322 DIKKELQKNLLDAQKHNSDI---NLYL-NEIANIYniLKLNKIKKI-IDEVKEYTKEIE---ENNKNIKDELD-KSEKLI 1392
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 941 KTIfQYTGQLNSLKA--ENTMLSSKLDNEKQNKERLETDVESFRSRLASALHDHAE----IQTAKRDLEIAFQRARDEWF 1014
Cdd:TIGR01612 1393 KKI-KDDINLEECKSkiESTLDDKDIDECIKKIKELKNHILSEESNIDTYFKNADEnnenVLLLFKNIEMADNKSQHILK 1471
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1015 RVKDK----MNFDMSNLRDNNEvlSQQLSKTERKLNSLEIE-----FHHTKDELRE-----KTLALKHaqrDLSQTQcqm 1080
Cdd:TIGR01612 1472 IKKDNatndHDFNINELKEHID--KSKGCKDEADKNAKAIEknkelFEQYKKDVTEllnkySALAIKN---KFAKTK--- 1543
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1081 KEVEHMFQDEQGKVSKFMGKQESIEERLAQLQSENTLLRqqlDDAANKAESkDKTIVNIQDQFQDVLTRFqaesqrhsLR 1160
Cdd:TIGR01612 1544 KDSEIIIKEIKDAHKKFILEAEKSEQKIKEIKKEKFRIE---DDAAKNDKS-NKAAIDIQLSLENFENKF--------LK 1611
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1161 LEDRNQELVSecshlrerlCQYENEKAEREVvvrqlqqeladtlkkqsmSEASLEVSSRYRSNLEEEARDLKKKLGQLRS 1240
Cdd:TIGR01612 1612 ISDIKKKIND---------CLKETESIEKKI------------------SSFSIDSQDTELKENGDNLNSLQEFLESLKD 1664
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1241 QLQEARDQHREAVHHAEKMEDHLQKLELEKSKFEITIKKQSEEIDQLQENlsrvnlseedkeklqKLTELKESLECTVDQ 1320
Cdd:TIGR01612 1665 QKKNIEDKKKELDELDSEIEKIEIDVDQHKKNYEIGIIEKIKEIAIANKE---------------EIESIKELIEPTIEN 1729
|
|
| PRK01156 |
PRK01156 |
chromosome segregation protein; Provisional |
686-1141 |
2.74e-03 |
|
chromosome segregation protein; Provisional
Pssm-ID: 100796 [Multi-domain] Cd Length: 895 Bit Score: 42.58 E-value: 2.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 686 HLRLECKDTASLLKIRDAVYSYKRLIELKRSHCELLTGKLKRMENKYKglqkEMSETEEVKSRLE-HEKVGWEQELCRLR 764
Cdd:PRK01156 236 NLKSALNELSSLEDMKNRYESEIKTAESDLSMELEKNNYYKELEERHM----KIINDPVYKNRNYiNDYFKYKNDIENKK 311
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 765 FALKQEEEKRRSADQLSEKTS--EQLRRKGEQCQSEVEARQQLEASLRTLEME----LKTVKShLNQVLEERNETQRQLS 838
Cdd:PRK01156 312 QILSNIDAEINKYHAIIKKLSvlQKDYNDYIKKKSRYDDLNNQILELEGYEMDynsyLKSIES-LKKKIEEYSKNIERMS 390
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 839 REQNARMLQDGILASHLCKQK-EIEMTQKKMTSEVSVSHEKEKDLLHKNQRLQDEVAVLRLE--------------MDTI 903
Cdd:PRK01156 391 AFISEILKIQEIDPDAIKKELnEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQsvcpvcgttlgeekSNHI 470
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 904 KSHNQEKEKRYLEDI--------KIANEKNDNLQRMVKLNEETFTKTIFQYTgQLNSLKAENTMLSSKLDNEKQNKERLE 975
Cdd:PRK01156 471 INHYNEKKSRLEEKIreieievkDIDEKIVDLKKRKEYLESEEINKSINEYN-KIESARADLEDIKIKINELKDKHDKYE 549
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 976 TDVESFRSRlasalhdhaeiqtakrDLEIAFQRaRDEWFRVKDKM-NFDMSNLRDNNEVLSQQLSKTERKLNSLEIEFHH 1054
Cdd:PRK01156 550 EIKNRYKSL----------------KLEDLDSK-RTSWLNALAVIsLIDIETNRSRSNEIKKQLNDLESRLQEIEIGFPD 612
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1055 TKD-------ELREKTLALKHAQRDLSQTQCQMKEVEHMFQDEQGKVSKFMGKQESIEERLAQLQSENTLLRQ---QLDD 1124
Cdd:PRK01156 613 DKSyidksirEIENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKsrkALDD 692
|
490
....*....|....*...
gi 124487433 1125 A-ANKAESKDKTIVNIQD 1141
Cdd:PRK01156 693 AkANRARLESTIEILRTR 710
|
|
| Mplasa_alph_rch |
TIGR04523 |
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ... |
1026-1553 |
3.23e-03 |
|
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.
Pssm-ID: 275316 [Multi-domain] Cd Length: 745 Bit Score: 42.31 E-value: 3.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1026 NLRDNNEVLSQQLSKterKLNSLEIEFHHTKDELR--EKTLALKHAQRDLSQTQcqMKEVEHMFQDEQGKVSKFMGKQES 1103
Cdd:TIGR04523 26 NIANKQDTEEKQLEK---KLKTIKNELKNKEKELKnlDKNLNKDEEKINNSNNK--IKILEQQIKDLNDKLKKNKDKINK 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1104 IEERLAQLQSENTLLRQQLDDAANKAESKDKTIVNIQDQFQDVLTRFqaesqrhsLRLEDRNQELVSECSHLRERLCQYE 1183
Cdd:TIGR04523 101 LNSDLSKINSEIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEI--------KKKEKELEKLNNKYNDLKKQKEELE 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1184 NEKAEREVVVRQLQQELADTLKKQSMSEASLEVSSRY-----------------RSNLEEEARDLKKKLGQLRSQLQEAR 1246
Cdd:TIGR04523 173 NELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNLKKKiqknkslesqiselkkqNNQLKDNIEKKQQEINEKTTEISNTQ 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1247 DQHREAVHHAEKMEDHLQKLELEKSKFEITIKKQSEEIDQLQENLSRVNlSEEDKEKLQKLTELKESLECTVDQEQKRSS 1326
Cdd:TIGR04523 253 TQLNQLKDEQNKIKKQLSEKQKELEQNNKKIKELEKQLNQLKSEISDLN-NQKEQDWNKELKSELKNQEKKLEEIQNQIS 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1327 ALEKELAEFKEVLKMTKKELNEYENRELNLRQDIKNNHLEmdipVSTLIKKIDDLTAKLETASSKCLHLGKKNQLLQQEL 1406
Cdd:TIGR04523 332 QNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNE----IEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLN 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1407 LLmrtIQKKCGKLEKNKKQLEQEVVNLRSHMEKNMVEHS--QAQQYAREVE----ERARQDLVEKLKQVNLFLQAQAASQ 1480
Cdd:TIGR04523 408 QQ---KDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKdlTNQDSVKELIiknlDNTRESLETQLKVLSRSINKIKQNL 484
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124487433 1481 ESLEQLRENSNA------SVRSQMELRIKDLESQLYRMKAQEdfDKIELEKYKQLYQEEFRARKSLSSKLNKTSEKLEE 1553
Cdd:TIGR04523 485 EQKQKELKSKEKelkklnEEKKELEEKVKDLTKKISSLKEKI--EKLESEKKEKESKISDLEDELNKDDFELKKENLEK 561
|
|
| EnvC |
COG4942 |
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ... |
1226-1467 |
3.60e-03 |
|
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 443969 [Multi-domain] Cd Length: 377 Bit Score: 41.67 E-value: 3.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1226 EEARDLKKKLGQLRSQLQEARDQHREAVHHAEKMEDHLQKLELEKSKFEITIKKQSEEIDQLQENLSRVNLSEEDKEKlq 1305
Cdd:COG4942 20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA-- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1306 KLTELKESLECTVDQEQKRSSALEKEL----AEFKEVLKMTK--KELNEYENRELN-LRQDIKNnhlemdipVSTLIKKI 1378
Cdd:COG4942 98 ELEAQKEELAELLRALYRLGRQPPLALllspEDFLDAVRRLQylKYLAPARREQAEeLRADLAE--------LAALRAEL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1379 DDLTAKLETAsskclhLGKKNQLLQQELLLMRTIQKKCGKLEKNKKQLEQEVVNLRSHMEKNMVEHSQAQQYAREVEERA 1458
Cdd:COG4942 170 EAERAELEAL------LAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERT 243
|
....*....
gi 124487433 1459 RQDLVEKLK 1467
Cdd:COG4942 244 PAAGFAALK 252
|
|
| PRK00409 |
PRK00409 |
recombination and DNA strand exchange inhibitor protein; Reviewed |
1206-1337 |
3.71e-03 |
|
recombination and DNA strand exchange inhibitor protein; Reviewed
Pssm-ID: 234750 [Multi-domain] Cd Length: 782 Bit Score: 42.12 E-value: 3.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1206 KQSMSEASLEVSsRYRSNLEEEARDLKKKLGQLRSQLQEARDQHREAVHHAEKMEDHLQKLELE-KSKFEITIKKQSEEI 1284
Cdd:PRK00409 508 KKLIGEDKEKLN-ELIASLEELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEaEKEAQQAIKEAKKEA 586
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 124487433 1285 DQLQENLSRVNLSEEDKEKLQKLTELKESLECTVDQEQKRSSALEKELAEFKE 1337
Cdd:PRK00409 587 DEIIKELRQLQKGGYASVKAHELIEARKRLNKANEKKEKKKKKQKEKQEELKV 639
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
147-175 |
3.72e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 36.41 E-value: 3.72e-03
10 20
....*....|....*....|....*....
gi 124487433 147 GNTALHYAVYSENTSMAAKLLAHNANIEA 175
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| PLN02939 |
PLN02939 |
transferase, transferring glycosyl groups |
1189-1562 |
4.14e-03 |
|
transferase, transferring glycosyl groups
Pssm-ID: 215507 [Multi-domain] Cd Length: 977 Bit Score: 41.81 E-value: 4.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1189 REVVVRQLQQELADTLKKQSMSEASLEVSSRYRSNLEEEARDLKKKLGQ--LRSQLQEARDQHREAVHHAEKMEDHLQKL 1266
Cdd:PLN02939 40 RGFSSQQKKKRGKNIAPKQRSSNSKLQSNTDENGQLENTSLRTVMELPQksTSSDDDHNRASMQRDEAIAAIDNEQQTNS 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1267 ELEKSKFEITIKKQSEEIDQLQENLSRVNLSE----EDKEKLqkLTElKESLectvdqeQKRSSALEKELAEFKEVLKMT 1342
Cdd:PLN02939 120 KDGEQLSDFQLEDLVGMIQNAEKNILLLNQARlqalEDLEKI--LTE-KEAL-------QGKINILEMRLSETDARIKLA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1343 KKELNEYENRE---LNLRQDIKNNHLEMDIPVSTLIKKIDDLtaKLETASSK--CLHLGKKNQLLQQELLLMRTIQKKCG 1417
Cdd:PLN02939 190 AQEKIHVEILEeqlEKLRNELLIRGATEGLCVHSLSKELDVL--KEENMLLKddIQFLKAELIEVAETEERVFKLEKERS 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1418 KLEKNKKQLEQEVVNLRSHMEKnmVEHSQAQQYAREVEERarQDLVEKLK----QVNLFLQAQAASQESLEQLRENSNAS 1493
Cdd:PLN02939 268 LLDASLRELESKFIVAQEDVSK--LSPLQYDCWWEKVENL--QDLLDRATnqveKAALVLDQNQDLRDKVDKLEASLKEA 343
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 124487433 1494 VRSQMELRIKDLESQlyRMKA-QEDFDKI--ELEKYKQLYQEefrarksLSSKLNKTSEKLEEASSKLLLEE 1562
Cdd:PLN02939 344 NVSKFSSYKVELLQQ--KLKLlEERLQASdhEIHSYIQLYQE-------SIKEFQDTLSKLKEESKKRSLEH 406
|
|
| PHA02736 |
PHA02736 |
Viral ankyrin protein; Provisional |
132-204 |
4.23e-03 |
|
Viral ankyrin protein; Provisional
Pssm-ID: 165103 [Multi-domain] Cd Length: 154 Bit Score: 39.47 E-value: 4.23e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 124487433 132 ILLDHGADPNVMDS-SGNTALHYAVYSENTSMAAKLLAH-NANIEAKNKDDLTPMLLAVKENKQHIVEFLVKKKA 204
Cdd:PHA02736 76 LLMEWGADINGKERvFGNTPLHIAVYTQNYELATWLCNQpGVNMEILNYAFKTPYYVACERHDAKMMNILRAKGA 150
|
|
| SMC_N |
pfam02463 |
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ... |
684-944 |
5.38e-03 |
|
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.
Pssm-ID: 426784 [Multi-domain] Cd Length: 1161 Bit Score: 41.50 E-value: 5.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 684 IEHLRLECKDTASLLKIRDAVYSYKRLIELKRSHCELLTGKLKRMENKYKGLQKEMSETEEVKSRLEHEKvgwEQELCRL 763
Cdd:pfam02463 755 SRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLI---EQEEKIK 831
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 764 RFALKQEEEKRRSADQLSEKTSEQLRRKGEQCQSEVEARQQLEASLRTLEMELKTVKSHLNQVLEERNETQRQLSR---E 840
Cdd:pfam02463 832 EEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQklnL 911
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 841 QNARMLQDGILASHLCKQKEIEMTQKKMTS-----EVSVSHEKEKDLLHKNQRLQDEVAVLRLEMDTIKSHNQEKEKRYL 915
Cdd:pfam02463 912 LEEKENEIEERIKEEAEILLKYEEEPEELLleeadEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYN 991
|
250 260 270
....*....|....*....|....*....|...
gi 124487433 916 ED----IKIANEKNDNLQRMVKLNEETFTKTIF 944
Cdd:pfam02463 992 KDelekERLEEEKKKLIRAIIEETCQRLKEFLE 1024
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
1166-1461 |
5.86e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 41.04 E-value: 5.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1166 QELVSECSHLRERLCQYENEKAEREVVVRQLQQELADTLKKQSMSEASLEVSSRYRSNLEEEARDLKKKLGQLRSQLQEA 1245
Cdd:COG4372 41 DKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEEL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1246 RDQHREAVHHAEKMEDHLQKLELEKSKFEITIKKQSEEIDQLQENLSRV---NLSEEDKEKLQKLTELKESLECTVDQEQ 1322
Cdd:COG4372 121 QKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALeqeLQALSEAEAEQALDELLKEANRNAEKEE 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1323 KRSSALEKELAEFKEVLKMTKKELNEYENRELNLRQDIKNNHLEMDIPVSTLIKKIDDLTAKLETASSKCLHLGKKNQLL 1402
Cdd:COG4372 201 ELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEI 280
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 124487433 1403 QQELLLMRTIQKKCGKLEKNKKQLEQEVVNLRSHMEKNMVEHSQAQQYAREVEERARQD 1461
Cdd:COG4372 281 AALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAEL 339
|
|
| RecN |
COG0497 |
DNA repair ATPase RecN [Replication, recombination and repair]; |
1101-1282 |
6.34e-03 |
|
DNA repair ATPase RecN [Replication, recombination and repair];
Pssm-ID: 440263 [Multi-domain] Cd Length: 555 Bit Score: 41.21 E-value: 6.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1101 QESIEERLAQLQSENTLLRQQLDDAANKAESkdktIVNIQDQFQDVLTRFQ-AESQrhslrLEDRNQELVSECSHLR--- 1176
Cdd:COG0497 225 REALQEALEALSGGEGGALDLLGQALRALER----LAEYDPSLAELAERLEsALIE-----LEEAASELRRYLDSLEfdp 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1177 ERLcqyeNEKAEREVVVRQLQQ-------ELADTLKKQSMSEASLEVSSRYRSNLEEEARDLKKKLGQLRSQLQEARdqh 1249
Cdd:COG0497 296 ERL----EEVEERLALLRRLARkygvtveELLAYAEELRAELAELENSDERLEELEAELAEAEAELLEAAEKLSAAR--- 368
|
170 180 190
....*....|....*....|....*....|....
gi 124487433 1250 REAVHH-AEKMEDHLQKLELEKSKFEITIKKQSE 1282
Cdd:COG0497 369 KKAAKKlEKAVTAELADLGMPNARFEVEVTPLEE 402
|
|
| mukB |
PRK04863 |
chromosome partition protein MukB; |
1105-1432 |
6.68e-03 |
|
chromosome partition protein MukB;
Pssm-ID: 235316 [Multi-domain] Cd Length: 1486 Bit Score: 41.48 E-value: 6.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1105 EERLAQlqsentlLRQQLDDAANKAESKDKTIVNIQDQFQDvLTRFQAESQRHSLRlEDRNQELVSecshLRERLCQYEN 1184
Cdd:PRK04863 785 EKRIEQ-------LRAEREELAERYATLSFDVQKLQRLHQA-FSRFIGSHLAVAFE-ADPEAELRQ----LNRRRVELER 851
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1185 EKAEREVVVRQLQQELaDTLKKQSMSEASLEVSSryrSNLEEEarDLKKKLGQLRSQLQEARDQHREAVHH---AEKMED 1261
Cdd:PRK04863 852 ALADHESQEQQQRSQL-EQAKEGLSALNRLLPRL---NLLADE--TLADRVEEIREQLDEAEEAKRFVQQHgnaLAQLEP 925
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1262 HLQKLELEKSKFEiTIKKQSEEIDQLQENLS------------RVNLSEEDKEK-LQKLTELKESLectvdqeQKRSSAL 1328
Cdd:PRK04863 926 IVSVLQSDPEQFE-QLKQDYQQAQQTQRDAKqqafaltevvqrRAHFSYEDAAEmLAKNSDLNEKL-------RQRLEQA 997
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1329 EKELAEFKEVLKMTKKELNEYENRELNL----------RQDIKNNHLEMDIPVST-----LIKKIDDLTAKLETASSKCL 1393
Cdd:PRK04863 998 EQERTRAREQLRQAQAQLAQYNQVLASLkssydakrqmLQELKQELQDLGVPADSgaeerARARRDELHARLSANRSRRN 1077
|
330 340 350
....*....|....*....|....*....|....*....
gi 124487433 1394 HLGKKnqlLQQELLLMRTIQKKCGKLEKNKKQLEQEVVN 1432
Cdd:PRK04863 1078 QLEKQ---LTFCEAEMDNLTKKLRKLERDYHEMREQVVN 1113
|
|
| PHA02946 |
PHA02946 |
ankyin-like protein; Provisional |
133-213 |
7.19e-03 |
|
ankyin-like protein; Provisional
Pssm-ID: 165256 [Multi-domain] Cd Length: 446 Bit Score: 40.81 E-value: 7.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 133 LLDHGADPNVMDSSGNTALHYAVYSENTSMAAKLLAHNANIEAKNKDDLTPMLLAVKENKQHI--VEFLVKKKASI-HAV 209
Cdd:PHA02946 58 LLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEVIerINLLVQYGAKInNSV 137
|
....
gi 124487433 210 DQLG 213
Cdd:PHA02946 138 DEEG 141
|
|
| PRK01156 |
PRK01156 |
chromosome segregation protein; Provisional |
881-1386 |
7.49e-03 |
|
chromosome segregation protein; Provisional
Pssm-ID: 100796 [Multi-domain] Cd Length: 895 Bit Score: 41.04 E-value: 7.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 881 DLLHKNQRLQDEVAVLRLEMD---TIKSHNQEKEKRYLEDIKIANEKNDN----LQRMVKLNEET--FTKTIFQYTGQLN 951
Cdd:PRK01156 187 YLEEKLKSSNLELENIKKQIAddeKSHSITLKEIERLSIEYNNAMDDYNNlksaLNELSSLEDMKnrYESEIKTAESDLS 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 952 SLKAENTMLSS------KLDNEKQNKER--------LETDVESFRSRLASALHDHAEIQTAKRDLEIaFQRARDEWF--- 1014
Cdd:PRK01156 267 MELEKNNYYKEleerhmKIINDPVYKNRnyindyfkYKNDIENKKQILSNIDAEINKYHAIIKKLSV-LQKDYNDYIkkk 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1015 RVKDKMNFDMSNLRDNNEVLSQQLSKTERKLNSLEIEFHHTKDELREKTLALKHAQRDLSQTQCQMKEVEHMFQDEQGKV 1094
Cdd:PRK01156 346 SRYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKELNEINVKLQDISSKV 425
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1095 SKFMGKQESIEERLAQLQSENTLLRQQLDDAANKAESKDKTIVNIQDQFQDVLTRFQAESQRHSLRLEDRNQELVsecsH 1174
Cdd:PRK01156 426 SSLNQRIRALRENLDELSRNMEMLNGQSVCPVCGTTLGEEKSNHIINHYNEKKSRLEEKIREIEIEVKDIDEKIV----D 501
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1175 LRERLCQYENEKAEREVVVRQLQQELADTLKKQSMSEASL--------EVSSRYRS----NLEEEARDLKKKLGQLRS-Q 1241
Cdd:PRK01156 502 LKKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELkdkhdkyeEIKNRYKSlkleDLDSKRTSWLNALAVISLiD 581
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1242 LQEARDQHREAVHHAEKMEDHLQKLELE----KSKFEITIKKQSEEIDQLQENLSRVNLSEEDKEKLQKLTELKESLECT 1317
Cdd:PRK01156 582 IETNRSRSNEIKKQLNDLESRLQEIEIGfpddKSYIDKSIREIENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAE 661
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 124487433 1318 VDQEQKRSSALEKELAEFKEVLKMTKKELNEYENRELNLRQDIKNNHLEmdipVSTLIKKIDDLTAKLE 1386
Cdd:PRK01156 662 IDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRTR----INELSDRINDINETLE 726
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
687-847 |
8.79e-03 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 40.91 E-value: 8.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 687 LRLECKDTASLLKIRDAVYSYKRLIELKRSHCELLTGKLKRMEnKYKGLQKEMSETEEVKSRLEHEKVGWE---QELCRL 763
Cdd:COG4717 80 LKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLE-KLLQLLPLYQELEALEAELAELPERLEeleERLEEL 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 764 RFALKQEEEKRRSADQLSEKTSEQLRRKGEQCQSEV----EARQQLEASLRTLEMELKTVKSHLNQVLEERNETQRQLSR 839
Cdd:COG4717 159 RELEEELEELEAELAELQEELEELLEQLSLATEEELqdlaEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEA 238
|
....*...
gi 124487433 840 EQNARMLQ 847
Cdd:COG4717 239 AALEERLK 246
|
|
| MukB |
COG3096 |
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ... |
921-1347 |
8.85e-03 |
|
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 442330 [Multi-domain] Cd Length: 1470 Bit Score: 41.09 E-value: 8.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 921 ANEKNDNLQRMVKLNEETFTKTifqytGQLNSLKAENTMLSSKLDNEKQNKERLETDVESFRSRLAsalhdhaEIQTAKR 1000
Cdd:COG3096 277 ANERRELSERALELRRELFGAR-----RQLAEEQYRLVEMARELEELSARESDLEQDYQAASDHLN-------LVQTALR 344
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1001 DLEiAFQRARDewfrvkdkmnfDMSNLRDNNEVLSQQLSKTERKLNSLEIEFHHTKDELREKTLALKHAQR--DLSQT-- 1076
Cdd:COG3096 345 QQE-KIERYQE-----------DLEELTERLEEQEEVVEEAAEQLAEAEARLEAAEEEVDSLKSQLADYQQalDVQQTra 412
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1077 -QCQ-----MKEVEHMFQDEQGKVSKFMGKQESIEERLAQLQSENTLLRQQL---DDAANKAESKDKTIVNIQDQfqdvL 1147
Cdd:COG3096 413 iQYQqavqaLEKARALCGLPDLTPENAEDYLAAFRAKEQQATEEVLELEQKLsvaDAARRQFEKAYELVCKIAGE----V 488
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1148 TRFQAESQRHSLRLEDRNQELVSE-CSHLRERLCQYENEKAEREVVVRQLQ---QELADTLKKQSMSEASLEVSSRYRSN 1223
Cdd:COG3096 489 ERSQAWQTARELLRRYRSQQALAQrLQQLRAQLAELEQRLRQQQNAERLLEefcQRIGQQLDAAEELEELLAELEAQLEE 568
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1224 LEEEARDLKKKLGQLRSQLQEARDQHREavhhaekmedhlqklelekskfeitIKKQSEEIDQLQENLSRvnLSEEDKEK 1303
Cdd:COG3096 569 LEEQAAEAVEQRSELRQQLEQLRARIKE-------------------------LAARAPAWLAAQDALER--LREQSGEA 621
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 124487433 1304 LQKLTELKESLECTVDQEQKRsSALEKELAEFKEVLKMTKKELN 1347
Cdd:COG3096 622 LADSQEVTAAMQQLLEREREA-TVERDELAARKQALESQIERLS 664
|
|
| COG4372 |
COG4372 |
Uncharacterized protein, contains DUF3084 domain [Function unknown]; |
1018-1348 |
9.19e-03 |
|
Uncharacterized protein, contains DUF3084 domain [Function unknown];
Pssm-ID: 443500 [Multi-domain] Cd Length: 370 Bit Score: 40.27 E-value: 9.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1018 DKMNFDMSNLRDNNEVLSQQLSKTERKLNSLEIEFHHTKDELREKTLALKHAQRDLSQTQCQMKEVEHMFQDEQGKVSKF 1097
Cdd:COG4372 34 RKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEEL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1098 MGKQESIEERLAQLQSENTLLRQQLDDAANKAESKDKTIVNIQDQFQDVLTRFQAESQRHSLRLEDRNQELVSECSHLRE 1177
Cdd:COG4372 114 QEELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEAN 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1178 RLCQYENEKAEREVVVRQLQQELADTLKKQSMSEaSLEVSSRYRSNLEEEARDLKKKLGQLRSQLQEARDQHREAVHHAE 1257
Cdd:COG4372 194 RNAEKEEELAEAEKLIESLPRELAEELLEAKDSL-EAKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKD 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1258 KMEDHLQKLELEKSKFEITIKKQSEE-----IDQLQENLSRVNLSEEDKEKLQKLTELKESLECTVDQEQKRSSALEKEL 1332
Cdd:COG4372 273 TEEEELEIAALELEALEEAALELKLLalllnLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLLLVGLLD 352
|
330
....*....|....*.
gi 124487433 1333 AEFKEVLKMTKKELNE 1348
Cdd:COG4372 353 NDVLELLSKGAEAGVA 368
|
|
| COG5022 |
COG5022 |
Myosin heavy chain [General function prediction only]; |
1030-1335 |
9.35e-03 |
|
Myosin heavy chain [General function prediction only];
Pssm-ID: 227355 [Multi-domain] Cd Length: 1463 Bit Score: 40.83 E-value: 9.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1030 NNEVLSQQLSKTERKLNSLEIEfhhTKDELREKTLA-LKHAQRDLSQTQCQMKEVEHMFQdeqgkvsKFMGKQESIEERL 1108
Cdd:COG5022 843 KAEVLIQKFGRSLKAKKRFSLL---KKETIYLQSAQrVELAERQLQELKIDVKSISSLKL-------VNLELESEIIELK 912
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1109 AQLQSentllrqqldDAANKAESKDKTIVNIQDQFQDVLTRFQAESQRHSLrleDRNQELVSECSHLRERLCQYENEKAE 1188
Cdd:COG5022 913 KSLSS----------DLIENLEFKTELIARLKKLLNNIDLEEGPSIEYVKL---PELNKLHEVESKLKETSEEYEDLLKK 979
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1189 REVVVRQLQQELADTLK-KQSMSEASLEvssryRSNLEEEARDLKKKLGQLRSQLQearDQHREAVHHAEKmedhLQKLE 1267
Cdd:COG5022 980 STILVREGNKANSELKNfKKELAELSKQ-----YGALQESTKQLKELPVEVAELQS---ASKIISSESTEL----SILKP 1047
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 124487433 1268 LEKSKFEITIKKQSEEIDQLQENLSRVNLSEEDKEKLQKLTELKESLECTVD--QEQKRSSALEKELAEF 1335
Cdd:COG5022 1048 LQKLKGLLLLENNQLQARYKALKLRRENSLLDDKQLYQLESTENLLKTINVKdlEVTNRNLVKPANVLQF 1117
|
|
| |
