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Conserved domains on  [gi|144226209|ref|NP_001077373|]
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fetuin-B isoform 2 [Mus musculus]

Protein Classification

CY domain-containing protein( domain architecture ID 10440427)

CY domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 77-161 4.32e-14

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


:

Pssm-ID: 425431  Cd Length: 92  Bit Score: 66.59  E-value: 4.32e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144226209   77 CPSPIDLSNPSALEAATESLAKFNSKSPSKKYELVKVTKAMNQWVSGPAYYVEYLIKEAPCTKSQ---ASCSLQhsDSEP 153
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSKSKkllEDCPLL--DEKW 79


                  ....*...
gi 144226209  154 VGICQGST 161
Cdd:pfam00031  80 LGLCSAQV 87
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 77-161 4.32e-14

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 66.59  E-value: 4.32e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144226209   77 CPSPIDLSNPSALEAATESLAKFNSKSPSKKYELVKVTKAMNQWVSGPAYYVEYLIKEAPCTKSQ---ASCSLQhsDSEP 153
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSKSKkllEDCPLL--DEKW 79


                  ....*...
gi 144226209  154 VGICQGST 161
Cdd:pfam00031  80 LGLCSAQV 87
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 73-157 5.31e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 64.37  E-value: 5.31e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144226209    73 TCPDCPSPIDLSNPSALEAATESLAKFNSKSpSKKYEL--VKVTKAMNQWVSGPAYYVEYLIKEAPCTKSQ---ASCSLQ 147
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKS-NDKYELrvIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSvdlENCPFL 79

                           90
                   ....*....|
gi 144226209   148 HsdsEPVGIC 157
Cdd:smart00043  80 D---QGEKFC 86
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 76-150 2.57e-09

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 54.02  E-value: 2.57e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 144226209  76 DCPSPIDLSNPSALEAATESLAKFNSKSPSKKYELVKVTKAMNQWVSGPAYYVEYLIKEAPCTKSQASCSLQHSD 150
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYLEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLDCPDCK 75
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 77-161 4.32e-14

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 66.59  E-value: 4.32e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144226209   77 CPSPIDLSNPSALEAATESLAKFNSKSPSKKYELVKVTKAMNQWVSGPAYYVEYLIKEAPCTKSQ---ASCSLQhsDSEP 153
Cdd:pfam00031   2 GLSPIPDNSPELQEALDFALAEYNAKTDNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSKSKkllEDCPLL--DEKW 79


                  ....*...
gi 144226209  154 VGICQGST 161
Cdd:pfam00031  80 LGLCSAQV 87
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 73-157 5.31e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 64.37  E-value: 5.31e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 144226209    73 TCPDCPSPIDLSNPSALEAATESLAKFNSKSpSKKYEL--VKVTKAMNQWVSGPAYYVEYLIKEAPCTKSQ---ASCSLQ 147
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKS-NDKYELrvIKVVSAKSQVVAGTNYYLKVEVGETNCKKLSvdlENCPFL 79

                           90
                   ....*....|
gi 144226209   148 HsdsEPVGIC 157
Cdd:smart00043  80 D---QGEKFC 86
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 76-150 2.57e-09

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 54.02  E-value: 2.57e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 144226209  76 DCPSPIDLSNPSALEAATESLAKFNSKSPSKKYELVKVTKAMNQWVSGPAYYVEYLIKEAPCTKSQASCSLQHSD 150
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYLEFFKVLSAKSQVVAGTNYYITVEAGDTNCKKSSVPLDCPDCK 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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