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Conserved domains on  [gi|168229148|ref|NP_001078969|]
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CDGSH iron-sulfur domain-containing protein 3, mitochondrial isoform 2 precursor [Mus musculus]

Protein Classification

CDGSH iron-sulfur domain-containing protein( domain architecture ID 15206804)

CDGSH iron-sulfur domain-containing protein binds a redox-active pH-labile 2Fe-2S cluster; similar to Mus musculus mitochondrial CDGSH iron-sulfur domain-containing protein 3, which can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2

Gene Ontology:  GO:0051537|GO:0106034|GO:0046872
PubMed:  29556009
SCOP:  3002112

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3369 COG3369
Uncharacterized conserved protein, contains Zn-finger domain of CDGSH type [Function unknown];
47-101 1.10e-14

Uncharacterized conserved protein, contains Zn-finger domain of CDGSH type [Function unknown];


:

Pssm-ID: 442596  Cd Length: 68  Bit Score: 63.95  E-value: 1.10e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 168229148  47 AKPVVAQKTPIRLEL------------VAGKTYRWCVCGRSKNQPFCDGSHffQRTGLSPLKFKAQE 101
Cdd:COG3369    4 VKITVAKNGPLLVEGdveivdadgneyEEGKRYALCRCGLSKNKPFCDGSH--KGTGFEPEGEAAEY 68
zf-CDGSH super family cl02748
Iron-binding zinc finger CDGSH type; The CDGSH-type zinc finger domain binds iron rather than ...
 100-124 1.03e-05

Iron-binding zinc finger CDGSH type; The CDGSH-type zinc finger domain binds iron rather than zinc as a redox-active pH-labile 2Fe-2S cluster. The conserved sequence C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H is a defining feature of this family. The domain is oriented towards the cytoplasm and is tethered to the mitochondrial membrane by a more N-terminal domain found in higher vertebrates, MitoNEET_N, pfam10660. The domain forms a uniquely folded homo-dimer and spans the outer mitochondrial membrane, orienting the iron-binding residues towards the cytoplasm.


The actual alignment was detected with superfamily member pfam09360:

Pssm-ID: 470664  Cd Length: 41  Bit Score: 39.97  E-value: 1.03e-05
                          10        20
                  ....*....|....*....|....*
gi 168229148  100 QETRTVALCTCKATQRPPYCDGTHK 124
Cdd:pfam09360  17 EGRFVVALCRCGRSKNKPFCDGSHK 41
 
Name Accession Description Interval E-value
COG3369 COG3369
Uncharacterized conserved protein, contains Zn-finger domain of CDGSH type [Function unknown];
47-101 1.10e-14

Uncharacterized conserved protein, contains Zn-finger domain of CDGSH type [Function unknown];


Pssm-ID: 442596  Cd Length: 68  Bit Score: 63.95  E-value: 1.10e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 168229148  47 AKPVVAQKTPIRLEL------------VAGKTYRWCVCGRSKNQPFCDGSHffQRTGLSPLKFKAQE 101
Cdd:COG3369    4 VKITVAKNGPLLVEGdveivdadgneyEEGKRYALCRCGLSKNKPFCDGSH--KGTGFEPEGEAAEY 68
ZnF_CDGSH smart00704
CDGSH-type zinc finger. Function unknown;
54-85 1.02e-09

CDGSH-type zinc finger. Function unknown;


Pssm-ID: 197836  Cd Length: 38  Bit Score: 50.42  E-value: 1.02e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 168229148    54 KTPIRLELVAGKTYRWCVCGRSKNQPFCDGSH 85
Cdd:smart00704   1 KRPDEVEVEKRKKYALCRCGRSKNFPYCDGSH 32
zf-CDGSH pfam09360
Iron-binding zinc finger CDGSH type; The CDGSH-type zinc finger domain binds iron rather than ...
 56-85 5.53e-09

Iron-binding zinc finger CDGSH type; The CDGSH-type zinc finger domain binds iron rather than zinc as a redox-active pH-labile 2Fe-2S cluster. The conserved sequence C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H is a defining feature of this family. The domain is oriented towards the cytoplasm and is tethered to the mitochondrial membrane by a more N-terminal domain found in higher vertebrates, MitoNEET_N, pfam10660. The domain forms a uniquely folded homo-dimer and spans the outer mitochondrial membrane, orienting the iron-binding residues towards the cytoplasm.


Pssm-ID: 462769  Cd Length: 41  Bit Score: 48.83  E-value: 5.53e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 168229148   56 PIRLELVAGKTYRW---------CVCGRSKNQPFCDGSH 85
Cdd:pfam09360   2 PLLVEDADGETVESregrfvvalCRCGRSKNKPFCDGSH 40
zf-CDGSH pfam09360
Iron-binding zinc finger CDGSH type; The CDGSH-type zinc finger domain binds iron rather than ...
 100-124 1.03e-05

Iron-binding zinc finger CDGSH type; The CDGSH-type zinc finger domain binds iron rather than zinc as a redox-active pH-labile 2Fe-2S cluster. The conserved sequence C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H is a defining feature of this family. The domain is oriented towards the cytoplasm and is tethered to the mitochondrial membrane by a more N-terminal domain found in higher vertebrates, MitoNEET_N, pfam10660. The domain forms a uniquely folded homo-dimer and spans the outer mitochondrial membrane, orienting the iron-binding residues towards the cytoplasm.


Pssm-ID: 462769  Cd Length: 41  Bit Score: 39.97  E-value: 1.03e-05
                          10        20
                  ....*....|....*....|....*
gi 168229148  100 QETRTVALCTCKATQRPPYCDGTHK 124
Cdd:pfam09360  17 EGRFVVALCRCGRSKNKPFCDGSHK 41
ZnF_CDGSH smart00704
CDGSH-type zinc finger. Function unknown;
93-129 1.12e-04

CDGSH-type zinc finger. Function unknown;


Pssm-ID: 197836  Cd Length: 38  Bit Score: 37.32  E-value: 1.12e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 168229148    93 SPLKFKAQETRTVALCTCKATQRPPYCDGTHKSEQVQ 129
Cdd:smart00704   2 RPDEVEVEKRKKYALCRCGRSKNFPYCDGSHKKHNEQ 38
 
Name Accession Description Interval E-value
COG3369 COG3369
Uncharacterized conserved protein, contains Zn-finger domain of CDGSH type [Function unknown];
47-101 1.10e-14

Uncharacterized conserved protein, contains Zn-finger domain of CDGSH type [Function unknown];


Pssm-ID: 442596  Cd Length: 68  Bit Score: 63.95  E-value: 1.10e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 168229148  47 AKPVVAQKTPIRLEL------------VAGKTYRWCVCGRSKNQPFCDGSHffQRTGLSPLKFKAQE 101
Cdd:COG3369    4 VKITVAKNGPLLVEGdveivdadgneyEEGKRYALCRCGLSKNKPFCDGSH--KGTGFEPEGEAAEY 68
ZnF_CDGSH smart00704
CDGSH-type zinc finger. Function unknown;
54-85 1.02e-09

CDGSH-type zinc finger. Function unknown;


Pssm-ID: 197836  Cd Length: 38  Bit Score: 50.42  E-value: 1.02e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 168229148    54 KTPIRLELVAGKTYRWCVCGRSKNQPFCDGSH 85
Cdd:smart00704   1 KRPDEVEVEKRKKYALCRCGRSKNFPYCDGSH 32
zf-CDGSH pfam09360
Iron-binding zinc finger CDGSH type; The CDGSH-type zinc finger domain binds iron rather than ...
 56-85 5.53e-09

Iron-binding zinc finger CDGSH type; The CDGSH-type zinc finger domain binds iron rather than zinc as a redox-active pH-labile 2Fe-2S cluster. The conserved sequence C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H is a defining feature of this family. The domain is oriented towards the cytoplasm and is tethered to the mitochondrial membrane by a more N-terminal domain found in higher vertebrates, MitoNEET_N, pfam10660. The domain forms a uniquely folded homo-dimer and spans the outer mitochondrial membrane, orienting the iron-binding residues towards the cytoplasm.


Pssm-ID: 462769  Cd Length: 41  Bit Score: 48.83  E-value: 5.53e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 168229148   56 PIRLELVAGKTYRW---------CVCGRSKNQPFCDGSH 85
Cdd:pfam09360   2 PLLVEDADGETVESregrfvvalCRCGRSKNKPFCDGSH 40
zf-CDGSH pfam09360
Iron-binding zinc finger CDGSH type; The CDGSH-type zinc finger domain binds iron rather than ...
 100-124 1.03e-05

Iron-binding zinc finger CDGSH type; The CDGSH-type zinc finger domain binds iron rather than zinc as a redox-active pH-labile 2Fe-2S cluster. The conserved sequence C-X-C-X2-(S/T)-X3-P-X-C-D-G-(S/A/T)-H is a defining feature of this family. The domain is oriented towards the cytoplasm and is tethered to the mitochondrial membrane by a more N-terminal domain found in higher vertebrates, MitoNEET_N, pfam10660. The domain forms a uniquely folded homo-dimer and spans the outer mitochondrial membrane, orienting the iron-binding residues towards the cytoplasm.


Pssm-ID: 462769  Cd Length: 41  Bit Score: 39.97  E-value: 1.03e-05
                          10        20
                  ....*....|....*....|....*
gi 168229148  100 QETRTVALCTCKATQRPPYCDGTHK 124
Cdd:pfam09360  17 EGRFVVALCRCGRSKNKPFCDGSHK 41
ZnF_CDGSH smart00704
CDGSH-type zinc finger. Function unknown;
93-129 1.12e-04

CDGSH-type zinc finger. Function unknown;


Pssm-ID: 197836  Cd Length: 38  Bit Score: 37.32  E-value: 1.12e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 168229148    93 SPLKFKAQETRTVALCTCKATQRPPYCDGTHKSEQVQ 129
Cdd:smart00704   2 RPDEVEVEKRKKYALCRCGRSKNFPYCDGSHKKHNEQ 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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