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Conserved domains on  [gi|157427830|ref|NP_001098822|]
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U3 small nucleolar RNA-associated protein 25 homolog [Bos taurus]

Protein Classification

UTP25 family protein( domain architecture ID 12072603)

UTP25 family protein similar to Homo sapiens U3 small nucleolar RNA-associated protein 25, a component of the ribosomal small subunit processome for the biogenesis of ribosomes, functions in pre-ribosomal RNA (pre-rRNA) processing

Gene Ontology:  GO:0034511|GO:0019843

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
UTP25 pfam06862
Utp25, U3 small nucleolar RNA-associated SSU processome protein 25; UTP25 is a family of ...
273-748 0e+00

Utp25, U3 small nucleolar RNA-associated SSU processome protein 25; UTP25 is a family of eukaryotic proteins. The family displays limited sequence similarity to DEAD-box RNA helicases, having alternative residues at the Walker A and DEAD-box sites, but conservation of structural and other key residues. The domain is required and sufficient for the interaction of Utp25 with Utp3. UTP25 interacts with nucleolar protein Nop19 in S. cerevisiae, and Nop19p is essential for the incorporation of Utp25p into pre-ribosomes.


:

Pssm-ID: 369113  Cd Length: 471  Bit Score: 754.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427830  273 TPLQKELFLIMNSYRDLFYPERTaLKNGEEIRHVYCLHVINHVLKANAQVLGNNSRRRSQKLGvgDDDDFRDQGLTRPKV 352
Cdd:pfam06862   1 TPLQKELFPPMFSYQDILYTNKS-YDDEEEYRKLYALHALNHVLKTRDRVLKNNSKLAKLKDN--DDLELRDQGFTRPKV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427830  353 LIVVPFREAALRVVQLFISLLEGDSkkkiiVSNKKRFNGEYGSDPEERPPNlkRPEDYEAVFVGNIDDHFRIGVAILQRS 432
Cdd:pfam06862  78 LILLPTRNSAYRVVELLIKLSGADQ-----VENKKRFNDEFSAEEEDPPTS--KPKDFQALFKGNTDDFFRLGIKFTRKS 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427830  433 IRLYAPFYSSDILIASPLGLRTIIGGEGEKKRDFDFLSSIELLIIDQADIYLMQNWEHVLHLMNHMNLLPLDSHGVDFSR 512
Cdd:pfam06862 151 IKLYSQFYSSDIIIASPLGLRMIIGNEDKKKRDFDFLSSIEVLIVDQADSIEMQNWEHVLTVFKHLNLIPKESHGCDFSR 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427830  513 VRMWSLNNWSKYYRQTLLFGALQDAQINSVFNKYCVNVQGQVAVRSVPMTGSISRVLVQLPHVFQRMQVESLASVIDARF 592
Cdd:pfam06862 231 VRMWYLDGQAKYYRQTIVFSSYITPEINSLFNSKCHNIAGKVRVKPIYKGGSIGQVGLKVRQVFQRFDADSIVDEPDARF 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427830  593 NFFVNKILPQYRDA--VMSHTLIYVPSYFDFVRLRNYFKKEELNFAHICEYTQKSGVSRARHFFLQGEKQFLLLTERFHF 670
Cdd:pfam06862 311 KFFTNNILPQLVKSsgYSSGTLIYIPSYFDFVRLRNYLKEENVSFGAISEYSSQKEVSRARTQFFSGRKKVLLYTERLHF 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427830  671 YKRYTIKGIRNLIFYELPTYPHFYSEVCNMLRATSRGEEA---AWTCTVLYSKYDAQRLAAVVGVERAAQMLQSKKNVHL 747
Cdd:pfam06862 391 FRRYEIKGVKNVIFYGLPENPQFYSELVRFLGKSVFEGDAdsnDGTVRALYSKYDALALERIVGTERAAKLLKSQKETYE 470

                  .
gi 157427830  748 F 748
Cdd:pfam06862 471 F 471
 
Name Accession Description Interval E-value
UTP25 pfam06862
Utp25, U3 small nucleolar RNA-associated SSU processome protein 25; UTP25 is a family of ...
273-748 0e+00

Utp25, U3 small nucleolar RNA-associated SSU processome protein 25; UTP25 is a family of eukaryotic proteins. The family displays limited sequence similarity to DEAD-box RNA helicases, having alternative residues at the Walker A and DEAD-box sites, but conservation of structural and other key residues. The domain is required and sufficient for the interaction of Utp25 with Utp3. UTP25 interacts with nucleolar protein Nop19 in S. cerevisiae, and Nop19p is essential for the incorporation of Utp25p into pre-ribosomes.


Pssm-ID: 369113  Cd Length: 471  Bit Score: 754.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427830  273 TPLQKELFLIMNSYRDLFYPERTaLKNGEEIRHVYCLHVINHVLKANAQVLGNNSRRRSQKLGvgDDDDFRDQGLTRPKV 352
Cdd:pfam06862   1 TPLQKELFPPMFSYQDILYTNKS-YDDEEEYRKLYALHALNHVLKTRDRVLKNNSKLAKLKDN--DDLELRDQGFTRPKV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427830  353 LIVVPFREAALRVVQLFISLLEGDSkkkiiVSNKKRFNGEYGSDPEERPPNlkRPEDYEAVFVGNIDDHFRIGVAILQRS 432
Cdd:pfam06862  78 LILLPTRNSAYRVVELLIKLSGADQ-----VENKKRFNDEFSAEEEDPPTS--KPKDFQALFKGNTDDFFRLGIKFTRKS 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427830  433 IRLYAPFYSSDILIASPLGLRTIIGGEGEKKRDFDFLSSIELLIIDQADIYLMQNWEHVLHLMNHMNLLPLDSHGVDFSR 512
Cdd:pfam06862 151 IKLYSQFYSSDIIIASPLGLRMIIGNEDKKKRDFDFLSSIEVLIVDQADSIEMQNWEHVLTVFKHLNLIPKESHGCDFSR 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427830  513 VRMWSLNNWSKYYRQTLLFGALQDAQINSVFNKYCVNVQGQVAVRSVPMTGSISRVLVQLPHVFQRMQVESLASVIDARF 592
Cdd:pfam06862 231 VRMWYLDGQAKYYRQTIVFSSYITPEINSLFNSKCHNIAGKVRVKPIYKGGSIGQVGLKVRQVFQRFDADSIVDEPDARF 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427830  593 NFFVNKILPQYRDA--VMSHTLIYVPSYFDFVRLRNYFKKEELNFAHICEYTQKSGVSRARHFFLQGEKQFLLLTERFHF 670
Cdd:pfam06862 311 KFFTNNILPQLVKSsgYSSGTLIYIPSYFDFVRLRNYLKEENVSFGAISEYSSQKEVSRARTQFFSGRKKVLLYTERLHF 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427830  671 YKRYTIKGIRNLIFYELPTYPHFYSEVCNMLRATSRGEEA---AWTCTVLYSKYDAQRLAAVVGVERAAQMLQSKKNVHL 747
Cdd:pfam06862 391 FRRYEIKGVKNVIFYGLPENPQFYSELVRFLGKSVFEGDAdsnDGTVRALYSKYDALALERIVGTERAAKLLKSQKETYE 470

                  .
gi 157427830  748 F 748
Cdd:pfam06862 471 F 471
DEADc_DDX51 cd17956
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ...
348-533 5.01e-05

DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350714 [Multi-domain]  Cd Length: 231  Bit Score: 45.32  E-value: 5.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427830 348 TRPKVLIVVPFREAALRVVQLFISLLEGDSKKKIIVSNKKRFNGEYGSDPEerppnlkrpedyeavfvgniddhfrigva 427
Cdd:cd17956   67 PRLRALIVVPTKELVQQVYKVFESLCKGTGLKVVSLSGQKSFKKEQKLLLV----------------------------- 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427830 428 ilQRSIRLYAPfysSDILIASPlG--LRTIIGGEGEKkrdfdfLSSIELLIIDQADIYLMQNWEHVL-HLMNHMNLLPLD 504
Cdd:cd17956  118 --DTSGRYLSR---VDILVATP-GrlVDHLNSTPGFT------LKHLRFLVIDEADRLLNQSFQDWLeTVMKALGRPTAP 185
                        170       180
                 ....*....|....*....|....*....
gi 157427830 505 SHGVDFSrvrmWSLNNWSKYYRQTLLFGA 533
Cdd:cd17956  186 DLGSFGD----ANLLERSVRPLQKLLFSA 210
 
Name Accession Description Interval E-value
UTP25 pfam06862
Utp25, U3 small nucleolar RNA-associated SSU processome protein 25; UTP25 is a family of ...
273-748 0e+00

Utp25, U3 small nucleolar RNA-associated SSU processome protein 25; UTP25 is a family of eukaryotic proteins. The family displays limited sequence similarity to DEAD-box RNA helicases, having alternative residues at the Walker A and DEAD-box sites, but conservation of structural and other key residues. The domain is required and sufficient for the interaction of Utp25 with Utp3. UTP25 interacts with nucleolar protein Nop19 in S. cerevisiae, and Nop19p is essential for the incorporation of Utp25p into pre-ribosomes.


Pssm-ID: 369113  Cd Length: 471  Bit Score: 754.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427830  273 TPLQKELFLIMNSYRDLFYPERTaLKNGEEIRHVYCLHVINHVLKANAQVLGNNSRRRSQKLGvgDDDDFRDQGLTRPKV 352
Cdd:pfam06862   1 TPLQKELFPPMFSYQDILYTNKS-YDDEEEYRKLYALHALNHVLKTRDRVLKNNSKLAKLKDN--DDLELRDQGFTRPKV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427830  353 LIVVPFREAALRVVQLFISLLEGDSkkkiiVSNKKRFNGEYGSDPEERPPNlkRPEDYEAVFVGNIDDHFRIGVAILQRS 432
Cdd:pfam06862  78 LILLPTRNSAYRVVELLIKLSGADQ-----VENKKRFNDEFSAEEEDPPTS--KPKDFQALFKGNTDDFFRLGIKFTRKS 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427830  433 IRLYAPFYSSDILIASPLGLRTIIGGEGEKKRDFDFLSSIELLIIDQADIYLMQNWEHVLHLMNHMNLLPLDSHGVDFSR 512
Cdd:pfam06862 151 IKLYSQFYSSDIIIASPLGLRMIIGNEDKKKRDFDFLSSIEVLIVDQADSIEMQNWEHVLTVFKHLNLIPKESHGCDFSR 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427830  513 VRMWSLNNWSKYYRQTLLFGALQDAQINSVFNKYCVNVQGQVAVRSVPMTGSISRVLVQLPHVFQRMQVESLASVIDARF 592
Cdd:pfam06862 231 VRMWYLDGQAKYYRQTIVFSSYITPEINSLFNSKCHNIAGKVRVKPIYKGGSIGQVGLKVRQVFQRFDADSIVDEPDARF 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427830  593 NFFVNKILPQYRDA--VMSHTLIYVPSYFDFVRLRNYFKKEELNFAHICEYTQKSGVSRARHFFLQGEKQFLLLTERFHF 670
Cdd:pfam06862 311 KFFTNNILPQLVKSsgYSSGTLIYIPSYFDFVRLRNYLKEENVSFGAISEYSSQKEVSRARTQFFSGRKKVLLYTERLHF 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427830  671 YKRYTIKGIRNLIFYELPTYPHFYSEVCNMLRATSRGEEA---AWTCTVLYSKYDAQRLAAVVGVERAAQMLQSKKNVHL 747
Cdd:pfam06862 391 FRRYEIKGVKNVIFYGLPENPQFYSELVRFLGKSVFEGDAdsnDGTVRALYSKYDALALERIVGTERAAKLLKSQKETYE 470

                  .
gi 157427830  748 F 748
Cdd:pfam06862 471 F 471
DEADc_DDX51 cd17956
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ...
348-533 5.01e-05

DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350714 [Multi-domain]  Cd Length: 231  Bit Score: 45.32  E-value: 5.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427830 348 TRPKVLIVVPFREAALRVVQLFISLLEGDSKKKIIVSNKKRFNGEYGSDPEerppnlkrpedyeavfvgniddhfrigva 427
Cdd:cd17956   67 PRLRALIVVPTKELVQQVYKVFESLCKGTGLKVVSLSGQKSFKKEQKLLLV----------------------------- 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157427830 428 ilQRSIRLYAPfysSDILIASPlG--LRTIIGGEGEKkrdfdfLSSIELLIIDQADIYLMQNWEHVL-HLMNHMNLLPLD 504
Cdd:cd17956  118 --DTSGRYLSR---VDILVATP-GrlVDHLNSTPGFT------LKHLRFLVIDEADRLLNQSFQDWLeTVMKALGRPTAP 185
                        170       180
                 ....*....|....*....|....*....
gi 157427830 505 SHGVDFSrvrmWSLNNWSKYYRQTLLFGA 533
Cdd:cd17956  186 DLGSFGD----ANLLERSVRPLQKLLFSA 210
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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