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Conserved domains on  [gi|161333841|ref|NP_001100046|]
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armadillo repeat-containing protein 10 [Rattus norvegicus]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 12058521)

armadillo/beta-catenin-like repeat-containing protein similar to armadillo repeat-containing protein and armadillo repeat-containing X-linked protein

CATH:  1.25.10.10
Gene Ontology:  GO:0098609|GO:0005515
PubMed:  12946625|9770300|9298899|20688255
SCOP:  3000116

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arm_2 pfam04826
Armadillo-like; This domain contains armadillo-like repeats. Proteins containing this domain ...
 56-276 1.17e-102

Armadillo-like; This domain contains armadillo-like repeats. Proteins containing this domain interact with numerous other proteins, through these interactions they are involved in a wide variety of processes including carcinogenesis, control of cellular ageing and survival, regulation of circadian rhythm and lysosomal sorting of G protein-coupled receptors.


:

Pssm-ID: 461447 [Multi-domain]  Cd Length: 221  Bit Score: 299.33  E-value: 1.17e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333841   56 LSAEQLEKLLYLLESTDDPIITEKALVTLGNNAAFSTNQAIIRELGGIPIVGSKINSLNQSIKEKALNALNNLSVNVENQ 135
Cdd:pfam04826   1 LEPQELDKLLALLKSSEDPFIHEIALITLGNSAAYPFNQDIIRDLGGIPIIANLLSDSNPEVKEKALNALNNLSMNVENQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333841  136 TKIKIYVRQVCEDVFADPLNSAVQLAALRLLTNMTVTNDYQHLLSNYITGLLHLLLIGNGSTKVQVLKLLLNLSENPAMT 215
Cdd:pfam04826  81 KKIKVYVNQVCKDIVSSPLNSEVQLAGLKLLTNLSVTNDYHHLVVSYIRDFFSLLSQGNEKTKFQVLKVLLNLSENPAMT 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161333841  216 EGLLSAQVDSSFLSLYDGQMANEILLRALTLFQNINNCLRVEGRLANQLPFAKGSLFFLLY 276
Cdd:pfam04826 161 RELLSAQVPSSLLSLFNSKEAKENLLRALTIFENINFHLKKEAKLFVKEHFTKGSLFSIFR 221
 
Name Accession Description Interval E-value
Arm_2 pfam04826
Armadillo-like; This domain contains armadillo-like repeats. Proteins containing this domain ...
 56-276 1.17e-102

Armadillo-like; This domain contains armadillo-like repeats. Proteins containing this domain interact with numerous other proteins, through these interactions they are involved in a wide variety of processes including carcinogenesis, control of cellular ageing and survival, regulation of circadian rhythm and lysosomal sorting of G protein-coupled receptors.


Pssm-ID: 461447 [Multi-domain]  Cd Length: 221  Bit Score: 299.33  E-value: 1.17e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333841   56 LSAEQLEKLLYLLESTDDPIITEKALVTLGNNAAFSTNQAIIRELGGIPIVGSKINSLNQSIKEKALNALNNLSVNVENQ 135
Cdd:pfam04826   1 LEPQELDKLLALLKSSEDPFIHEIALITLGNSAAYPFNQDIIRDLGGIPIIANLLSDSNPEVKEKALNALNNLSMNVENQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333841  136 TKIKIYVRQVCEDVFADPLNSAVQLAALRLLTNMTVTNDYQHLLSNYITGLLHLLLIGNGSTKVQVLKLLLNLSENPAMT 215
Cdd:pfam04826  81 KKIKVYVNQVCKDIVSSPLNSEVQLAGLKLLTNLSVTNDYHHLVVSYIRDFFSLLSQGNEKTKFQVLKVLLNLSENPAMT 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161333841  216 EGLLSAQVDSSFLSLYDGQMANEILLRALTLFQNINNCLRVEGRLANQLPFAKGSLFFLLY 276
Cdd:pfam04826 161 RELLSAQVPSSLLSLFNSKEAKENLLRALTIFENINFHLKKEAKLFVKEHFTKGSLFSIFR 221
 
Name Accession Description Interval E-value
Arm_2 pfam04826
Armadillo-like; This domain contains armadillo-like repeats. Proteins containing this domain ...
 56-276 1.17e-102

Armadillo-like; This domain contains armadillo-like repeats. Proteins containing this domain interact with numerous other proteins, through these interactions they are involved in a wide variety of processes including carcinogenesis, control of cellular ageing and survival, regulation of circadian rhythm and lysosomal sorting of G protein-coupled receptors.


Pssm-ID: 461447 [Multi-domain]  Cd Length: 221  Bit Score: 299.33  E-value: 1.17e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333841   56 LSAEQLEKLLYLLESTDDPIITEKALVTLGNNAAFSTNQAIIRELGGIPIVGSKINSLNQSIKEKALNALNNLSVNVENQ 135
Cdd:pfam04826   1 LEPQELDKLLALLKSSEDPFIHEIALITLGNSAAYPFNQDIIRDLGGIPIIANLLSDSNPEVKEKALNALNNLSMNVENQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161333841  136 TKIKIYVRQVCEDVFADPLNSAVQLAALRLLTNMTVTNDYQHLLSNYITGLLHLLLIGNGSTKVQVLKLLLNLSENPAMT 215
Cdd:pfam04826  81 KKIKVYVNQVCKDIVSSPLNSEVQLAGLKLLTNLSVTNDYHHLVVSYIRDFFSLLSQGNEKTKFQVLKVLLNLSENPAMT 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161333841  216 EGLLSAQVDSSFLSLYDGQMANEILLRALTLFQNINNCLRVEGRLANQLPFAKGSLFFLLY 276
Cdd:pfam04826 161 RELLSAQVPSSLLSLFNSKEAKENLLRALTIFENINFHLKKEAKLFVKEHFTKGSLFSIFR 221
Atx10homo_assoc pfam09759
Spinocerebellar ataxia type 10 protein domain; This is the conserved C-terminal 100 residues ...
 92-138 3.60e-03

Spinocerebellar ataxia type 10 protein domain; This is the conserved C-terminal 100 residues of Ataxin-10. Ataxin-10 belongs to the family of armadillo repeat proteins and in solution it tends to form homotrimeric complexes, which associate via a tip-to-tip association in a horseshoe-shaped contact with the concave sides of the molecules facing each other. This domain may represent the homo-association site since that is located near the C-terminus of Ataxin-10. The protein does not contain a signal sequence for secretion or any subcellular compartment confirming its cytoplasmic localization, specifically to the olivocerebellar region.


Pssm-ID: 462885 [Multi-domain]  Cd Length: 99  Bit Score: 36.29  E-value: 3.60e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 161333841   92 TNQAIIRELGGIPIVGS--KINSLNQSIKEKALNALNNLSV-NVENQTKI 138
Cdd:pfam09759  18 EVQDEVRELGGLPLILSncNIDDNNPFIREWAIFCIRNLLEgNEENQELI 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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