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Conserved domains on  [gi|157819153|ref|NP_001100953|]
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interferon regulatory factor 2-binding protein 1 [Rattus norvegicus]

Protein Classification

interferon regulatory factor 2-binding protein( domain architecture ID 12109086)

interferon regulatory factor 2-binding protein (IRF-2BP) such as IRF-2BP1, a nuclear protein that binds to the C-terminal repression domain of IRF-2 and acts as an IRF-2-dependent transcriptional corepressor, both enhancer-activated and basal transcription; may also act as an E3 ubiquitin-protein ligase

CATH:  3.30.40.10
EC:  2.3.2.27
Gene Ontology:  GO:0016567|GO:0004842|GO:0008270|GO:0003714
PubMed:  12799427|11007473|19489725
SCOP:  3000160

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RING_Ubox super family cl17238
RING finger (Really Interesting New Gene) domain and U-box domain superfamily; The RING finger ...
 500-561 2.62e-40

RING finger (Really Interesting New Gene) domain and U-box domain superfamily; The RING finger is a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc. It is defined by the "cross-brace" motif that chelates zinc atoms by eight amino acid residues, typically Cys or His, arranged in a characteristic spacing. Canonical RING motifs have been categorized into two major subclasses, RING-HC (C3HC4-type) and RING-H2 (C3H2C3-type), according to their Cys/His content. There are also many variants of RING fingers: some have different Cys/His patterns while some lack a single Cys or His residue at typical Zn ligand positions (the fourth or eighth zinc ligand is prevalently exchanged for an Asp, which can indeed chelate Zn in a RING finger as well). C4C4-, C3HC3D-, C2H2C4-, and C3HC5-type RING fingers are closely related to RING-HC fingers. In contrast, C4HC3- (RING-CH alias RINGv), C3H3C2-, C3H2C2D-, C3DHC3-, and C4HC2H-type RING fingers are more closely related to RING-H2 fingers. However, not all RING finger-containing proteins display regular RING finger features, and the RING finger family has turned out to be multifarious. The degenerate RING fingers of the Siz/PIAS RING (SP-RING) family proteins and sporulation protein RMD5, are characterized by lacking the second, fifth, and sixth Zn2+ ion-coordinating residues. They bind only one Zn2+ ion. On the other hand, the RING fingers of the human APC11 and RBX1 proteins can bind a third Zn atom since they harbor four additional Zn ligands. U-box is a modified form of the RING finger domain that lacks metal chelating Cys and His residues. It resembles the cross-brace RING structure consisting of three beta-sheets and a single alpha-helix, which would be stabilized by salt bridges instead of chelated metal ions. U-box proteins are widely distributed among eukaryotic organisms and show a higher prevalence in plants than in other organisms. RING finger/U-box-containing proteins are a group of diverse proteins with a variety of cellular functions, including oncogenesis, development, viral replication, signal transduction, the cell cycle and apoptosis. Many of them are ubiquitin-protein ligases (E3s) that serve as scaffolds for binding to ubiquitin-conjugating enzymes (E2s, also referred to as ubiquitin carrier proteins or UBCs) in close proximity to substrate proteins, which enable efficient transfer of ubiquitin from E2 to the substrates.


The actual alignment was detected with superfamily member cd16715:

Pssm-ID: 473075  Cd Length: 62  Bit Score: 140.51  E-value: 2.62e-40
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157819153 500 PLCCTLCRERLEDTHFVQCPSVPGHKFCFPCSREFIKAQGPAGEVYCPSGDKCPLVGSSVPW 561
Cdd:cd16715    1 PLCCTICHERLEDTHFVQCPSVPGHKFCFPCSRDFIKAQGPAGEVYCPSGDKCPLVGSNVPW 62
IRF-2BP1_2 pfam11261
Interferon regulatory factor 2-binding protein zinc finger; IRF-2BP1 and IRF-2BP2 are nuclear ...
 8-59 1.19e-29

Interferon regulatory factor 2-binding protein zinc finger; IRF-2BP1 and IRF-2BP2 are nuclear transcriptional repressor proteins and can inhibit both enhancer-activated and basal transcription. They both contain N-terminal zinc finger represented in this family and C-terminal RING finger domains.


:

Pssm-ID: 463250  Cd Length: 52  Bit Score: 110.70  E-value: 1.19e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 157819153    8 RRQWCYLCDLPKMPWAMVWDFSEAVCRGCVNFEGADRIELLIDAARQLKRSH 59
Cdd:pfam11261   1 RRQKCYLCDLPRGPWAMIWDFSEPVCRGCVNYEGADRIELVIDKARQLKRSH 52
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 338-463 6.88e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 6.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819153  338 VRSFREPAPAEALPQQYPEPAPAALCGPPPRAPSRNLAPTPRRRKASPEPEGETAGKMTTEEQQQRHWVA-------PGG 410
Cdd:PHA03247 2695 LTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAgppapapPAA 2774

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 157819153  411 PYSTETPGVPSPIAALKNVAEALGHSPKDPGGGGGSVRAGGASPAASSTTQPP 463
Cdd:PHA03247 2775 PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGP 2827
 
Name Accession Description Interval E-value
vRING-HC_IRF2BP1 cd16715
variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein 1 ...
 500-561 2.62e-40

variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein 1 (IRF-2BP1); IRF-2BP1, also known as IRF-2-binding protein 1, is a nuclear protein that binds to the C-terminal repression domain of IRF-2 and acts as an IRF-2-dependent transcriptional corepressor, both enhancer-activated and basal transcription. It binds to Jun-dimerization protein 2 (JDP2), a member of the activating protein-1 (AP-1) family of transcription factors, and enhances the polyubiquitination of JDP2. It also represses activating transcription factor-2 (ATF2)-mediated transcriptional activation from a cyclic AMP-responsive element (CRE)-containing promoter. IRF-2BP1 contains an N-terminal C4-type zinc finger and a C-terminal variant C3HC4-type RING-HC finger.


Pssm-ID: 438375  Cd Length: 62  Bit Score: 140.51  E-value: 2.62e-40
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157819153 500 PLCCTLCRERLEDTHFVQCPSVPGHKFCFPCSREFIKAQGPAGEVYCPSGDKCPLVGSSVPW 561
Cdd:cd16715    1 PLCCTICHERLEDTHFVQCPSVPGHKFCFPCSRDFIKAQGPAGEVYCPSGDKCPLVGSNVPW 62
IRF-2BP1_2 pfam11261
Interferon regulatory factor 2-binding protein zinc finger; IRF-2BP1 and IRF-2BP2 are nuclear ...
 8-59 1.19e-29

Interferon regulatory factor 2-binding protein zinc finger; IRF-2BP1 and IRF-2BP2 are nuclear transcriptional repressor proteins and can inhibit both enhancer-activated and basal transcription. They both contain N-terminal zinc finger represented in this family and C-terminal RING finger domains.


Pssm-ID: 463250  Cd Length: 52  Bit Score: 110.70  E-value: 1.19e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 157819153    8 RRQWCYLCDLPKMPWAMVWDFSEAVCRGCVNFEGADRIELLIDAARQLKRSH 59
Cdd:pfam11261   1 RRQKCYLCDLPRGPWAMIWDFSEPVCRGCVNYEGADRIELVIDKARQLKRSH 52
zf-C3HC4 pfam00097
Zinc finger, C3HC4 type (RING finger); The C3HC4 type zinc-finger (RING finger) is a ...
 503-547 3.48e-03

Zinc finger, C3HC4 type (RING finger); The C3HC4 type zinc-finger (RING finger) is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C where X is any amino acid. Many proteins containing a RING finger play a key role in the ubiquitination pathway.


Pssm-ID: 395049 [Multi-domain]  Cd Length: 40  Bit Score: 35.41  E-value: 3.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 157819153  503 CTLCRERLEDTHFV-QCpsvpGHKFCFPCSREFIKaqgpAGEVYCP 547
Cdd:pfam00097   1 CPICLEEPKDPVTLlPC----GHLFCSKCIRSWLE----SGNVTCP 38
PHA03247 PHA03247
large tegument protein UL36; Provisional
 338-463 6.88e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 6.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819153  338 VRSFREPAPAEALPQQYPEPAPAALCGPPPRAPSRNLAPTPRRRKASPEPEGETAGKMTTEEQQQRHWVA-------PGG 410
Cdd:PHA03247 2695 LTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAgppapapPAA 2774

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 157819153  411 PYSTETPGVPSPIAALKNVAEALGHSPKDPGGGGGSVRAGGASPAASSTTQPP 463
Cdd:PHA03247 2775 PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGP 2827
 
Name Accession Description Interval E-value
vRING-HC_IRF2BP1 cd16715
variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein 1 ...
 500-561 2.62e-40

variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein 1 (IRF-2BP1); IRF-2BP1, also known as IRF-2-binding protein 1, is a nuclear protein that binds to the C-terminal repression domain of IRF-2 and acts as an IRF-2-dependent transcriptional corepressor, both enhancer-activated and basal transcription. It binds to Jun-dimerization protein 2 (JDP2), a member of the activating protein-1 (AP-1) family of transcription factors, and enhances the polyubiquitination of JDP2. It also represses activating transcription factor-2 (ATF2)-mediated transcriptional activation from a cyclic AMP-responsive element (CRE)-containing promoter. IRF-2BP1 contains an N-terminal C4-type zinc finger and a C-terminal variant C3HC4-type RING-HC finger.


Pssm-ID: 438375  Cd Length: 62  Bit Score: 140.51  E-value: 2.62e-40
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157819153 500 PLCCTLCRERLEDTHFVQCPSVPGHKFCFPCSREFIKAQGPAGEVYCPSGDKCPLVGSSVPW 561
Cdd:cd16715    1 PLCCTICHERLEDTHFVQCPSVPGHKFCFPCSRDFIKAQGPAGEVYCPSGDKCPLVGSNVPW 62
vRING-HC_IRF2BP2 cd16716
variant of RING finger, HC subclass, found in interferon regulatory factor 2 (IRF2)-binding ...
 500-566 1.06e-36

variant of RING finger, HC subclass, found in interferon regulatory factor 2 (IRF2)-binding protein 2 (IRF-2BP2); IRF-2BP2, also known as IRF-2-binding protein 2 or DIF-1, is a nuclear protein that binds to the C-terminal repression domain of IRF-2 and acts as an IRF-2-dependent transcriptional corepressor, both enhancer-activated and basal transcription. IRF-2BP2 also specifically interacts with the C-terminal domain of the nuclear factor of activated T cells NFAT1 transcription factor, and negatively regulates the NFAT1-dependent transactivation of NFAT-responsive promoters. Moreover, IRF2BP2 suppresses the transactivation activity of p53 on both Bax and p21 promoters. It also shows anti-apoptotic activity through the modulation of the death domain in NRIF3. In addition, IRF2BP2 functions as a cofactor of VGLL4 and plays a critical role controlling gene expression in skeletal, cardiac, and smooth muscle cells. It is a muscle-enriched transcription factor required to activate vascular endothelial growth factor-A (VEGF-A) expression. IRF-2BP2 contains an N-terminal C4-type zinc finger and a C-terminal variant C3HC4-type RING-HC finger. The zinc finger is responsible for the homo- and hetero-dimerization between different members of the IRF-2BP2 family. The RING-HC finger interacts with IRF2 and also with nuclear receptor interacting factor 3 (NRIF3).


Pssm-ID: 438376  Cd Length: 67  Bit Score: 130.98  E-value: 1.06e-36
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157819153 500 PLCCTLCRERLEDTHFVQCPSVPGHKFCFPCSREFIKAQGPAGEVYCPSGDKCPLVGSSVPWAFMQG 566
Cdd:cd16716    1 PLCCTLCHERLEDTHFVQCPSVPSHKFCFPCSRESIKQQGATGEVYCPSGEKCPLVGSNVPWAFMQG 67
vRING-HC_IRF2BP1-like cd16511
variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein ...
 501-556 2.24e-35

variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein IRF-2BP1, IRF-2BP2, and similar proteins; This subfamily includes IRF-2BP1, IRF-2BP2, and their homolog, IRF-2BP-like, also known as IRF-2BPL or C14orf4. IRF-2BP1 and IRF-2BP2 are nuclear proteins that bind to the C-terminal repression domain of IRF-2 and act as IRF-2-dependent transcriptional corepressors, both enhancer-activated and basal transcription. IRF-2BPL is expressed in the mediobasal hypothalamus and plays a critical function in regulating the female reproductive neuroendocrine axis. All subfamily members contain a C-terminal variant C3HC4-type RING-HC finger.


Pssm-ID: 438174  Cd Length: 56  Bit Score: 126.77  E-value: 2.24e-35
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 157819153 501 LCCTLCRERLEDTHFVQCPSVPGHKFCFPCSREFIKAQGPAGEVYCPSGDKCPLVG 556
Cdd:cd16511    1 LCCTLCHERLEDTHFVQCPSVPSHKFCFPCSRDSIKRQGAGGEVYCPSGEKCPLVG 56
vRING-HC_IRF2BPL cd16717
variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding ...
 499-561 6.98e-35

variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein-like (IRF-2BPL); IRF-2BPL, also known as C14orf4 or enhanced at puberty protein 1(EAP1), is a homolog of interferon regulatory factor 2-binding proteins, IRF-2BP1 and IRF-2BP2. It is expressed in the mediobasal hypothalamus and plays a critical function in regulating the female reproductive neuroendocrine axis. IRF-2BPL is a proline-rich protein with polyglutamine and polyalanine tracks at the N-terminus and a C3HC4-type RING-HC finger domain with a partially new pattern at the C-terminus.


Pssm-ID: 438377  Cd Length: 66  Bit Score: 125.98  E-value: 6.98e-35
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157819153 499 APLCCTLCRERLEDTHFVQCPSVPGHKFCFPCSREFIKAQGPAGEVYCPSGDKCPLVGSSVPW 561
Cdd:cd16717    4 GPLCCTICHERLEDTHFVQCPSVPSHKFCFPCSRESIKAQGATGEVYCPSGEKCPLVGSNVPW 66
IRF-2BP1_2 pfam11261
Interferon regulatory factor 2-binding protein zinc finger; IRF-2BP1 and IRF-2BP2 are nuclear ...
 8-59 1.19e-29

Interferon regulatory factor 2-binding protein zinc finger; IRF-2BP1 and IRF-2BP2 are nuclear transcriptional repressor proteins and can inhibit both enhancer-activated and basal transcription. They both contain N-terminal zinc finger represented in this family and C-terminal RING finger domains.


Pssm-ID: 463250  Cd Length: 52  Bit Score: 110.70  E-value: 1.19e-29
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 157819153    8 RRQWCYLCDLPKMPWAMVWDFSEAVCRGCVNFEGADRIELLIDAARQLKRSH 59
Cdd:pfam11261   1 RRQKCYLCDLPRGPWAMIWDFSEPVCRGCVNYEGADRIELVIDKARQLKRSH 52
RING-HC cd16449
HC subclass of RING (RING-HC) finger and its variants; The RING finger is a specialized type ...
 501-547 2.33e-05

HC subclass of RING (RING-HC) finger and its variants; The RING finger is a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc. It is defined by the "cross-brace" motif that chelates zinc atoms by eight amino acid residues, typically Cys or His, arranged in a characteristic spacing. Canonical RING motifs have been categorized into two major subclasses, RING-HC (C3HC4-type) and RING-H2 (C3H2C3-type), according to their Cys/His content. There are also many variants of RING fingers. Some have a different Cys/His pattern. Some lack a single Cys or His residue at typical Zn ligand positions, especially, the fourth or eighth zinc ligand is prevalently exchanged for an Asp, which can chelate Zn in a RING finger as well. This family corresponds to the HC subclass of RING (RING-HC) fingers that are characterized by containing C3HC4-type canonical RING-HC fingers or noncanonical RING-HC finger variants, including C4C4-, C3HC3D-, C2H2C4-, and C3HC5-type modified RING-HC fingers. The canonical RING-HC finger has been defined as C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C. It binds two Zn ions in a unique "cross-brace" arrangement, which distinguishes it from tandem zinc fingers and other similar motifs. RING-HC fingers can be found in a group of diverse proteins with a variety of cellular functions, including oncogenesis, development, viral replication, signal transduction, the cell cycle, and apoptosis. Many of them are ubiquitin-protein ligases (E3s) that serve as scaffolds for binding to ubiquitin-conjugating enzymes (E2s, also referred to as ubiquitin carrier proteins or UBCs) in close proximity to substrate proteins, which enables efficient transfer of ubiquitin from E2 to the substrates.


Pssm-ID: 438113 [Multi-domain]  Cd Length: 41  Bit Score: 41.70  E-value: 2.33e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 157819153 501 LCCTLCRERLEDTHFVQCpsvpGHKFCFPCSREFIKaqgpAGEVYCP 547
Cdd:cd16449    1 LECPICLERLKDPVLLPC----GHVFCRECIRRLLE----SGSIKCP 39
RING-HC_TRIM69_C-IV cd16611
RING finger, HC subclass, found in tripartite motif-containing protein 69 (TRIM69) and similar ...
 501-547 3.26e-03

RING finger, HC subclass, found in tripartite motif-containing protein 69 (TRIM69) and similar proteins; TRIM69, also known as RFP-like domain-containing protein trimless or RING finger protein 36 (RNF36), is a testis E3 ubiquitin-protein ligase that plays a specific role in apoptosis and may also play an important role in germ cell homeostasis during spermatogenesis. TRIM69 belongs to the C-IV subclass of the TRIM (tripartite motif) family of proteins that are defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil region, as well as a B30.2/SPRY (SplA and ryanodine receptor) domain positioned C-terminal to the RBCC domain.


Pssm-ID: 438273 [Multi-domain]  Cd Length: 59  Bit Score: 36.27  E-value: 3.26e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 157819153 501 LCCTLCRERLEDTHFVQCpsvpGHKFCFPCSREFIKAQgpAGEVYCP 547
Cdd:cd16611    5 LHCPLCLDFFRDPVMLSC----GHNFCQSCITGFWELQ--AEDTTCP 45
zf-C3HC4 pfam00097
Zinc finger, C3HC4 type (RING finger); The C3HC4 type zinc-finger (RING finger) is a ...
 503-547 3.48e-03

Zinc finger, C3HC4 type (RING finger); The C3HC4 type zinc-finger (RING finger) is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C where X is any amino acid. Many proteins containing a RING finger play a key role in the ubiquitination pathway.


Pssm-ID: 395049 [Multi-domain]  Cd Length: 40  Bit Score: 35.41  E-value: 3.48e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 157819153  503 CTLCRERLEDTHFV-QCpsvpGHKFCFPCSREFIKaqgpAGEVYCP 547
Cdd:pfam00097   1 CPICLEEPKDPVTLlPC----GHLFCSKCIRSWLE----SGNVTCP 38
PHA03247 PHA03247
large tegument protein UL36; Provisional
 338-463 6.88e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 6.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819153  338 VRSFREPAPAEALPQQYPEPAPAALCGPPPRAPSRNLAPTPRRRKASPEPEGETAGKMTTEEQQQRHWVA-------PGG 410
Cdd:PHA03247 2695 LTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAgppapapPAA 2774

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 157819153  411 PYSTETPGVPSPIAALKNVAEALGHSPKDPGGGGGSVRAGGASPAASSTTQPP 463
Cdd:PHA03247 2775 PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGP 2827
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
342-463 9.70e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.09  E-value: 9.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157819153 342 REPAPAEALPQQYPEPAPAAlcgPPPRAPSRNLAPTPRRRkaSPEPEGETAGKMTTEEQQQRHWVAPGGPYSTETPGVPS 421
Cdd:PRK12323 390 AAPAAAAPAPAAPPAAPAAA---PAAAAAARAVAAAPARR--SPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARP 464

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 157819153 422 PIAALKNVAEALGHSPkdpgggggSVRAGGASPAASSTTQPP 463
Cdd:PRK12323 465 AAAGPRPVAAAAAAAP--------ARAAPAAAPAPADDDPPP 498
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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