|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
40-468 |
3.83e-147 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 426.65 E-value: 3.83e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 40 YFLSWSGFLVSFMMRNDMNFALVAMIANDNSTQNQSLI--KSQQILGTGTDDQKTIVKSVVISSFYWCYVLSQVVGGVAT 117
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTStdKDTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 118 ELFGTKCVFGWSQLATALCSFMMPSAAQLHYIAVIVLRSIQGFASGLTWPAMYAIVGYWIPLTERSR-FMSSFQGFSIGI 196
Cdd:cd17318 81 EKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRlTSIAYSGSQFGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 197 GLTYPLCGFILSEWGWPYIFYTTGTLGLGWCILWYLLafntprehpritkdelnyielnvkkevnssvkvkvpwlqifkS 276
Cdd:cd17318 161 VIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFL------------------------------------------V 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 277 IPAWAIAITTFGRIFVHYIFIVNGPTFMGNVLKFNFETNGFLSGVPFICSYISSVLFCYIADKIVFYKVLCLTNVRKVFT 356
Cdd:cd17318 199 LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTTVRKLFT 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 357 ALSQIIPGVLIYCIGYI-DNVYILLTVWFIAVIFITASYAGAMANIIDLAPNYghSAAVLAFCQTIHMSASFISPLTAGF 435
Cdd:cd17318 279 SIGFLGPGVFLIALGYLgSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNY--AGTLMGITNTAATIAGIISPLIVGA 356
|
410 420 430
....*....|....*....|....*....|...
gi 281366707 436 IVTQEDSIDQWRRVFEVSAIISILTYLFYQLFG 468
Cdd:cd17318 357 IVKNDQTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
34-477 |
7.68e-66 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 220.00 E-value: 7.68e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 34 PARLVLYFLSWsGFLVSFMMRNDM----------NFALVAMIANDNSTQNQSLIKSQQI--LGTGTDDQKTIVKSVVISS 101
Cdd:TIGR00894 6 ASTKLPYFCSF-RLFLSFLLHICNviiiaqriclSLTMVAMVNKENSTDLACLSAENELdnIKNPNFKWSGALQGLILSS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 102 FYWCYVLSQVVGGVATELFGTKCVFGWSQLATALCSFMMPSAAQLHYIAVIVLRSIQGFASGLTWPAMYAIVGYWIPLTE 181
Cdd:TIGR00894 85 HFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKWAPPKE 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 182 RSRFMS-SFQGFSIGIGLTYPLCGFILSEW-GWPYIFYTTGTLGLGWCILWYLLAFNTPREHPRITKDELNYIELNVKKE 259
Cdd:TIGR00894 165 RSRLLGmSTSGFQLGTFIFLPISGWLCESWgGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSSLQGQ 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 260 VNSSVKvKVPWLQIFKSIPAWAIAITTFGRIFVHYIFIVNGPTFMGNVLKFNFETNGFLSGVPFICSYISSVLFCYIADK 339
Cdd:TIGR00894 245 KGSTRQ-SLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADF 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 340 IVFYKVLCLTNVRKVFTALSQIIPGVLIYCIGYID-NVYILLTVWFIAVIFITASYAGAMANIIDLAPNYGHSAAVLAFC 418
Cdd:TIGR00894 324 LKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSaAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKGITGL 403
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 281366707 419 qtIHMSASFISPLTAGFIVTQeDSIDQWRRVFEVSAIISILTYLFYQLFGTAEIQTWNK 477
Cdd:TIGR00894 404 --PGFIGGLIASTLAGNILSQ-DSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAK 459
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
39-468 |
6.89e-54 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 186.52 E-value: 6.89e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 39 LYFLSWSGFLVSFMMRNDMNFALVAMI-----ANDNSTQN-----QSLIKSQQILGTGTDDQKTIVKSVVISSFYWCYVL 108
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVDMVnsnstLPSNNSSNacpehSSSPSVEHNETGKKYDWDAETQGWILGSFFYGYII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 109 SQVVGGVATELFGTKCVFGWSQLATALCSFMMPSAAQLHYIAVIVLRSIQGFASGLTWPAMYAIVGYWIPLTERSRFMS- 187
Cdd:cd17381 81 TQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTi 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 188 SFQGFSIGIGLTYPLCGFILSEWGWPYIFYTTGTLGLGWCILWYLLAfntprehpritkdelnyielnvkkevnssvkvk 267
Cdd:cd17381 161 SYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV--------------------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 268 vpwlqifksIPAWAIAITTFGRIFVHYIFIVNGPTFMGNVLKFNFETNGFLSGVPFICSYISSVLFCYIADKIVFYKVLC 347
Cdd:cd17381 208 ---------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQNFS 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 348 LTNVRKVFTALSQIIPGVLIYCIGYIDNVYILltvwfiAVIFITAS-------YAGAMANIIDLAPNYghSAAVLAFCQT 420
Cdd:cd17381 279 TVCVRKIFTLIGMIGPAVFLLAAGFTGCNYSL------AVAFLTISstlggfsASGFNINHLDIAPSY--AGILLGITNT 350
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 281366707 421 IHMSASFISPLTAGFIvTQEDSIDQWRRVFEVSAIISILTYLFYQLFG 468
Cdd:cd17381 351 FATIPGMVGPVIAKSL-THNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
94-468 |
1.07e-48 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 171.58 E-value: 1.07e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 94 VKSVVISSFYWCYVLSQVVGGVATELFGTKCVFGWSQLATALCSFMMPSAAQLHYIAVIVLRSIQGFASGLTWPAMYAIV 173
Cdd:cd17380 35 DQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLF 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 174 GYWIPLTERSRFMS-SFQGFSIGIGLTYPLCGFILSEWGWPYIFYTTGTLGLGWCILWYLLAfntprehpritkdelnyi 252
Cdd:cd17380 115 SRWVPVSERSRAVSiVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYL------------------ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 253 elnvkkevnssvkvkvpwlqifksIPAWAIAITTFGRIFVHYIFIVNGPTFMGNVLkFNFETNGFLSGVPFICSYISSVL 332
Cdd:cd17380 177 ------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMFPSSNV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 333 FCYIADKIVfYKVLCLTNVRKVFTALSQIIPGVLIYCIGYIDNVYILLTVWFIAVIFITASYAGAMANIIDLAPNygHSA 412
Cdd:cd17380 232 AGWLADHLI-SRGWTVTSVRKLMQSIGFLGPALFLLLLSHTDSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPN--YAG 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 281366707 413 AVLAFCQTIHMSASFISPLTAGFIVTQEDSidqWRRVFEVSAIISILTYLFYQLFG 468
Cdd:cd17380 309 IVFGISNTAGTIPGIVGVYLTGYILEATGS---WSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
41-468 |
1.31e-45 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 163.66 E-value: 1.31e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 41 FLSWSGFLVSFMMRNDMNFALVAMIANDNSTQNQSLIKSQ-QILGTGTddqktiVKSVVISSFYWCYVLSQVVGGVATEL 119
Cdd:cd17382 2 IMAGLGFCISFGIRCNLGVAIVRMVNNFTDAYGGKVIVHKaEFNWTPE------TVGLIESSFFWGYLVTQIPGGFIAAK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 120 FGTKCVFGWSQLATALCSFMMPSAAQLHYIAVIVLRSIQGFASGLTWPAMYAIVGYWIPLTERSRFMS-SFQGFSIGIGL 198
Cdd:cd17382 76 FAANRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATtAFCGSYAGAVV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 199 TYPLCGFILSEWGWPYIFYTTGTLGLGWCILWYLLafntprehpritkdelnyielnvkkevnssvkvkvpwlqifkSIP 278
Cdd:cd17382 156 GMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWMLV------------------------------------------SMP 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 279 AWAIAITTFGRIFVHYIFIVNGPTFMGNVLKFNFETNGFLSGVPFICSYISSVLFCYIADKIVFYKVLCLTNVRKVFTAL 358
Cdd:cd17382 194 VYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNCG 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 359 SQIIPGVLIYCIGYIDNVYILLTVWFIAVIFITASYAGAMANIIDLAPNYghsAAVL-AFCQTIHMSASFISPLTAGFIv 437
Cdd:cd17382 274 GFGMEATFLLVVAFSHSPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRY---ASILmGISNGIGTLSGMVCPVIVGAL- 349
|
410 420 430
....*....|....*....|....*....|.
gi 281366707 438 TQEDSIDQWRRVFEVSAIISILTYLFYQLFG 468
Cdd:cd17382 350 TKHKTREEWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
36-468 |
1.04e-31 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 125.37 E-value: 1.04e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 36 RLVLYFLSWSGFLVSFMMRNDMNFALVAMIANDNSTQNQSliksqqilgtgtddqktivkSVVISSFYWCYVLSQVVGGV 115
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQL--------------------GLLASAFFLGYALGQIPAGL 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 116 ATELFGTKCVFGWSQLATALCSFMMPSAAqlHYIAVIVLRSIQGFASGLTWPAMYAIVGYWIPLTERSRFMSSFQ-GFSI 194
Cdd:COG2271 68 LADRFGRRRVLAIGLLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNaGGPL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 195 GIGLTYPLCGFILSEWGWPYIFYTTGTLGLGWCILWYllafntprehpritkdelnyielnvkkevnssvkvkvpwlqif 274
Cdd:COG2271 146 GGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRF------------------------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 275 ksipaWAIAITTFGRIFVHYIFIVNGPTFMGNVLKFNFETNGFLSGVPFICSYISSVLFCYIADKIVfykvlcltNVRKV 354
Cdd:COG2271 183 -----WLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLG--------RRRKL 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 355 FTALSQIIPGVLIYCIGYIDNVYILLTVWFIAVIFITASYAGAMANIIDLAPNyGHSAAVLAFCQTIHMSASFISPLTAG 434
Cdd:COG2271 250 VLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPK-KARGTASGLVNTFGFLGGALGPLLVG 328
|
410 420 430
....*....|....*....|....*....|....
gi 281366707 435 FIVTQEDsidqWRRVFEVSAIISILTYLFYQLFG 468
Cdd:COG2271 329 YLLDATG----YQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
98-463 |
4.60e-29 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 117.67 E-value: 4.60e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 98 VISSFYWCYVLSQVVGGVATELFGTKCVFGWSQLATALCSFMMPSAAQLhyIAVIVLRSIQGFASGLTWPAMYAIVGYWI 177
Cdd:cd17319 43 IASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSL--TSLYVLRFLLGVAEAGFFPGAIKALAEWF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 178 PLTERSRFMSSF-QGFSIGIGLTYPLCGFILSEWGWPYIFYTTGTLGLGWCILWYLLAFNTprehpritkdelnyielnv 256
Cdd:cd17319 121 PARERGRATGLFnSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQV------------------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 257 kkevnssvkvkvpwlqifksipaWAIAITTFGRIFVHYIFIVNGPTFMGNVLKFNFETNGFLSGVPFICSYISSVLFCYI 336
Cdd:cd17319 182 -----------------------WGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 337 ADKIvfykvlcLTNVRKVFTALSQIIPGVLIYCIGYIDNVYILLTVWFIAVIFITASYAGAMANIIDLAPnYGHSAAVLA 416
Cdd:cd17319 239 SDRL-------LRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLP-GEAAATAGG 310
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 281366707 417 FCQTIHMSASFISPLTAGFIVTQEDSIDQWRRVFEVSAIISILTYLF 463
Cdd:cd17319 311 LINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
96-430 |
2.18e-25 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 106.73 E-value: 2.18e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 96 SVVISSFYWCYVLSQVVGGVATELFGTKCVFGWSQLATALCSFMMPSAAQLhyIAVIVLRSIQGFASGLTWPAMYAIVGY 175
Cdd:pfam07690 35 GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL--WLLLVLRVLQGLGAGALFPAALALIAD 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 176 WIPLTERSRFMSSFQ-GFSIGIGLTYPLCGFILSEWGWPYIFYTTGTLGLGWCILWYLLAFNTPREHPRITKDELnyiel 254
Cdd:pfam07690 113 WFPPEERGRALGLVSaGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEAR----- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 255 nvkkevnssVKVKVPWLQIFKSIPAWAIaITTFGRIFVHYIFIVNGPTFMgNVLKFNFETNGFLSGVPFICSYISSVLFC 334
Cdd:pfam07690 188 ---------LSLIVAWKALLRDPVLWLL-LALLLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAIGRLLLG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 335 YIADKIVfykvlclTNVRKVFTALSQIIPGVLIYCIGYIDNVYILLTVWFIAVIFITASYAGAMANIIDLAPNyGHSAAV 414
Cdd:pfam07690 257 RLSDRLG-------RRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPK-EERGTA 328
|
330
....*....|....*.
gi 281366707 415 LAFCQTIHMSASFISP 430
Cdd:pfam07690 329 SGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
96-459 |
8.22e-25 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 105.74 E-value: 8.22e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 96 SVVISSFYWCYVLSQVVGGVATELFGTKCVFGWSQLATALCSFMMPSAAqlHYIAVIVLRSIQGFASGLTWPAMYAIVGY 175
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT--SYWQLLLARFLQGLASAAVWPAAMALIAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 176 WIPLTERSRFMSSFQ-GFSIGIGLTYPLCGFILSEWGWPYIFYTTGTLGLgWCILWYLLAFNTPREhpritkdelnyiel 254
Cdd:cd17325 112 IAPPEERGRAMGIFSsAIGLGFLIGPLLGGLLADALGYRAPFLVCAALAL-LALVLALLLLPEPRP-------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 255 NVKKEVNSSVKVKVPWLQIFKSIPAWAIAITTFGRIFVHYIFIVNGPTFMGNVLKFNFETNGFLSGVPFICSYISSVLFC 334
Cdd:cd17325 177 PPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 335 YIADKIVFYKVLcltnvrkvftALSQIIPGVLIYCIGYIDNVYILLTVWFIAVIFITASYAGAMANIIDLAPNyGHSAAV 414
Cdd:cd17325 257 KLSDRIGRKPLI----------LIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPP-EGRGTA 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 281366707 415 LAFCQTIHMSASFISPLTAGFIVTQEDsidqWRRVFEVSAIISIL 459
Cdd:cd17325 326 MGLFNTAFSLGMVLGPLLGGFLYDAFG----FATPFLAAAALLLL 366
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
96-426 |
1.69e-24 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 104.29 E-value: 1.69e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 96 SVVISSFYWCYVLSQVVGGVATELFGTKCVFGWSQLATALCSFMMPSAAqlHYIAVIVLRSIQGFASGLTWPAMYAIVGY 175
Cdd:COG2814 48 GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP--SLWLLLAARFLQGLGAGALFPAALALIAD 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 176 WIPLTERSRFMSSFQ-GFSIGIGLTYPLCGFILSEWGWPYIFYTTGTLGLgwcILWYLLAFNTPREHPRitkdelnyiel 254
Cdd:COG2814 126 LVPPERRGRALGLLGaGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLAL---LALLLLLRLLPESRPA----------- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 255 nvkkevnSSVKVKVPWLQIFKSIPAWAIAITTFGRIFVHYIFIVNGPTFMGNVLKFNFETNGFLSGVPFICSYISSVLFC 334
Cdd:COG2814 192 -------ARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAG 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 335 YIADKIVFYKVLcltnvrkvftALSQIIPGVLIYCIGYIDNVYILLTVWFIAVIFITASYAGAMANIIDLAPNyGHSAAV 414
Cdd:COG2814 265 RLADRFGRRRLL----------LIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPP-EARGRA 333
|
330
....*....|..
gi 281366707 415 LAFCQTIHMSAS 426
Cdd:COG2814 334 SGLYNSAFFLGG 345
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
96-464 |
4.54e-23 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 100.58 E-value: 4.54e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 96 SVVISSFYWCYVLSQVVGGVATELFGTKCVFGWSQLATALCSFMMPSAAQlhYIAVIVLRSIQGFASGLTWPAMYAIVGY 175
Cdd:cd06174 34 GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPS--FWLLLLGRFLLGLGSGLIDPAVLALIAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 176 WIPLTERSRFMSSFQGF-SIGIGLTYPLCGFILS--EWGWPYIFYTTGTLGLGWCILWYLLAFNTPREHPRitkdelnyi 252
Cdd:cd06174 112 LFPERERGRALGLLQAFgSVGGILGPLLGGILASslGFGWRAVFLIAAALALLAAILLLLVVPDPPESARA--------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 253 elnvKKEVNSSVKVKVPWLQIFKSIPAWAIAITTFGRIFVHYIFIVNGPTFMGNVLKFNFETNGFLSGVPFICSYISSVL 332
Cdd:cd06174 183 ----KNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 333 FCYIADKIVfykvlcltnVRKVFTALSQIIPGVLIYCIGYIDNVYiLLTVWFIAVIFITASYAGAMANIIDLAPNYGHSA 412
Cdd:cd06174 259 LGLLSDRLI---------GRKPLLLIGLLLMALGLALLLLAPSLL-LLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRG 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 281366707 413 AVLAFCQTIHMSASFISPLTAGFIvtqEDSIDQWRRVFEVSAIISILTYLFY 464
Cdd:cd06174 329 TAFGLLNTFGFLGGAIGPLLAGFL---LAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
98-417 |
1.24e-19 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 90.51 E-value: 1.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 98 VISSFYWCYVLSQVVGGVATELFGTKCVFGWSQLATALCSFMMpsAAQLHYIAVIVLRSIQGFASGLTWPAMYAIVGYWI 177
Cdd:TIGR00881 35 LLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFF--GFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWF 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 178 PLTERSRFMSSFQ-GFSIGIGLTYPLCGFILSE-WGWPYIFYTTGTLGLGWCILWYLLAFNTPREhPRITKDELNYIE-- 253
Cdd:TIGR00881 113 SRSERGTWVSFWNcSHNVGGGLLPPLVLFGIAElYSWHWVFIVPGIIAIIVSLICFLLLRDSPQS-CGLPPAEEMPNEep 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 254 -LNVKKEVNSSVKVKVPWLQIFKSIPAWAIAITTFGRIFVHYIFIVNGPTFMGNVLKFNFETNGFLSGVPFICSYISSVL 332
Cdd:TIGR00881 192 dGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLL 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 333 FCYIADKI---------VFYK--VLCLTNVRKVFTALSQIIPGVLIYCIGYIDNVYILLTvWFIAVIFITASYAGAMANI 401
Cdd:TIGR00881 272 AGWLSDKLfngrrgplaVFFMalIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPQMLI-GVIASELAPKKAAGTAAGF 350
|
330
....*....|....*.
gi 281366707 402 IDLAPNYGHSAAVLAF 417
Cdd:TIGR00881 351 VGFFAYLGGILAGLPL 366
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
95-459 |
2.96e-19 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 89.55 E-value: 2.96e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 95 KSVVISSFYWCYVLSQVVGGVATELFGTKCVFGWSQLATALCSFMMPSAAQlhYIAVIVLRSIQGFASGLTWPAMYAIVG 174
Cdd:COG2223 42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVS--YWLLLLLGLLLGIGGGGSFAVGIALVS 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 175 YWIPLTERSRFMSSFQG-FSIGIGLTYPLCGFILSEWGWPYIFYTTGTLGLGWCILWYLLAFNTPREHPRITKDELNyie 253
Cdd:COG2223 120 KWFPPDRRGLALGLAAGgGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLR--- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 254 lnvkkevnssvkvkvPWLQIFKSIPAWAIAITTFGRIFVHYIFIVNGPTFMGNVLKFNFETNGFLSGVPFICSYISSVLF 333
Cdd:COG2223 197 ---------------DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 334 CYIADKIVFYKVLCltnvrkVFTALSQIIPGVLIYCIGYIDNVYILLTVWFIAVIFITASYAGAMANIIDLApnygHSAA 413
Cdd:COG2223 262 GWLSDRIGGRRVLL------IVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTK----NAGA 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 281366707 414 VLAFCQTIHMSASFISPLTAGFIVtqeDSIDQWRRVFEVSAIISIL 459
Cdd:COG2223 332 VYGLVGAAGGLGGFLGPLLFGALL---DATGSYTAAFLVFAVLALV 374
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
98-406 |
1.80e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 62.57 E-value: 1.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 98 VISSFYWCYVLSQVVGGVATELFGTKCVFGWSQLATALCSFMmpSAAQLHYIAVIVLRSIQGFASGLTWPAMYAIVGYWI 177
Cdd:cd17324 39 LVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL--AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 178 PLTERSRFMSSFQ-GFSIGIGLTYPLCGFILSEWGWPYIFYTTGTLGL-GWCILWYLLafntprehPRItkdelnyieln 255
Cdd:cd17324 117 PPEKRGRAIGLVFsGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALlAALLLWRLL--------PSL----------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 256 vKKEVNSSVKVKVPWLQIFKSIPAWAIAITTFGRIFVHYIFIVNGPTFMGNVLKFNFETNGFLSGVPFICSYISSVLFCY 335
Cdd:cd17324 178 -PPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGR 256
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281366707 336 IADKIVFYKVLcltnvrkVFTALSQIIPGVLIYCIGYIDNVYILLTVWFIAvifITASYAGAMANIIDLAP 406
Cdd:cd17324 257 LADRGGRRALL-------IALLLLAAALLLLTLLGPSPLLLLVGLVLWGLG---FFAAHSALQTRVLRLAP 317
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
96-430 |
1.13e-09 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 60.34 E-value: 1.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 96 SVVISSFYWCYVLSQVVGGVATELFGTKCVFGWSQLATALCSFMMpsAAQLHYIAVIVLRSIQGFASGLTWPAMYAIVGY 175
Cdd:cd17327 44 NWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLT--AAVKNFGGLIALRFFLGLFESGVFPGFILYLGM 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 176 WIPLTE---RSRFMSSFQGFS------IGIGLTYPLCGFILSEWGWPYIFytTGTLGLGWCILWYLLAFNTPREHPRITK 246
Cdd:cd17327 122 WYKREEqakRIAFFYAAAGLGsifgglLAYGVFKILGVGGLAGWRWLFII--EGLITIIIGLVIFFWLPDNPSKAWFLTE 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 247 DE----LNYIELNVKKEVNSSVKVKVpWLQIFKSIPAWAIAITTFGRIFVHYIFIVNGPTFMGNVLKFNFETNgFLSGVP 322
Cdd:cd17327 200 EEkelaVERLRANQTGKGDQKFKWKQ-IKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSLGFYSLQTN-LLSVPI 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 323 FICSYISSVLFCYIADKIvfykvlcltNVRKVFTALSQIIPGVLIYCIGYIDNVYILLTVWFIAVIFITASYAGAMANII 402
Cdd:cd17327 278 GALGAVSLLIAALLSDRF---------KKRGLFAIFACVLALVGSIILLAAPNPPGAYFAAYILGGGSYAGFPILLSWIS 348
|
330 340
....*....|....*....|....*...
gi 281366707 403 DLAPNYGHSAAVLAFCQTIHMSASFISP 430
Cdd:cd17327 349 SNCAGYTKRATVLAIMLIFYNVGNIVAP 376
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
96-233 |
1.77e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 59.05 E-value: 1.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 96 SVVISSFYWCYVLSQVVGGVATELFGTKCVFGWSQLATALCSFMM---PSAAQLhyiavIVLRSIQGFASGLTWPAMYAI 172
Cdd:COG0477 52 GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCglaPSPELL-----IAARALQGIGAGGLMPGALAL 126
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281366707 173 VGYWIPLTERSRFMSSFQ-GFSIGIGLTYPLCGFILSEWGWPYIFYTTGTLGLGWCILWYLL 233
Cdd:COG0477 127 IAELFPARERGRALGLWGaAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
100-239 |
2.34e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 56.13 E-value: 2.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 100 SSFYWCYVLSQVVGGVATELFGTKCVFGWSQLATALCSFMMpsAAQLHYIAVIVLRSIQGFASGLTWPAMYAIVGYWIPL 179
Cdd:cd17312 45 SAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFM--GFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSK 122
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 281366707 180 TERSRFMSSFQGFS-IGIGLTYPLCGFILSEWGWPYIFYTTGTLGLGWCILWYLLAFNTPR 239
Cdd:cd17312 123 KERGTVYGIWSTSHnFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSPP 183
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
148-468 |
3.73e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 55.27 E-value: 3.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 148 YIAVIVLRSIQGFASGLTWPAMYAIVGYWIPLTERSRFMSSFQGFSIGIGLTYPLCGFILSEWGWPYIFYTtgtLGLGWC 227
Cdd:cd17473 88 LYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLV---YLLALP 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 228 ILWYLLAFNTPREHPRITKDElnyielnvkkeVNSSVKVKVPWLQIfksipaWAIAITTFGRIFVHYIFIVNGPTFMGNV 307
Cdd:cd17473 165 VLILVLLFLPEPARKSKSAAS-----------PGAATAAALPWKRV------LPIYFLAFLAMLLFYVIPIQLPFLLQER 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 308 LKFNFETNGFLSGVPFICSYISSVLFCYIADKIVFYKVLCLtnvrkvftalsqiipGVLIYCIGYIdnvyILLTVWFIAV 387
Cdd:cd17473 228 GGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAI---------------GFALMALGFL----LLALASGLWV 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 388 IFITASYAGA---------MANIIDLAPnYGHSAAVLAFCQTIHMSASFISPLTAGFIVTQEDSIDQwrrVFEVSAIISI 458
Cdd:cd17473 289 VLLGAILAGLgfglllptlNSWAMSLVP-PELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSG---AFLILGVLAL 364
|
330
....*....|
gi 281366707 459 LTYLFYQLFG 468
Cdd:cd17473 365 VLAIVLLLLR 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
282-464 |
4.10e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 52.04 E-value: 4.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 282 IAITTFGRIFVHYIFIVNGPTFMGNVLKFNFETNGFLSGVPFICSYISSVLFCYIADKIvfykvlcltNVRKVFtALSQI 361
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF---------GRRRVL-LIGLL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 362 IPGVLIYCIGYIDNVYILLTVWFIAVIFITASYAGAMANIIDLAPNyGHSAAVLAFCQTIHMSASFISPLTAGFIVTQED 441
Cdd:pfam07690 71 LFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPP-EERGRALGLVSAGFGLGAALGPLLGGLLASLFG 149
|
170 180
....*....|....*....|...
gi 281366707 442 sidqWRRVFEVSAIISILTYLFY 464
Cdd:pfam07690 150 ----WRAAFLILAILSLLAAVLL 168
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
148-467 |
5.91e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 51.42 E-value: 5.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 148 YIAVIVLRSIQGFASGLTWPAMYAIVGYWIPLTERSRFMSSFQGfSIGIGL-TYPLCGFILSEWGWPYIFYTTGTLGL-- 224
Cdd:cd17474 87 FALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEA-ALGLGIaVGPLLGGLLAAISWRYPFFLLAALIPva 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 225 GWCILWYLlafntprEHPRitkdelnyielnvKKEVNSSVKVKVPWLQIFKSIPAWAIAITTFGRIFVHYIFIVNGPTFM 304
Cdd:cd17474 166 FLAILFLL-------PEPK-------------EKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLL 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 305 GNVLKFNFETNGFLSGVPFICSYISSVLFCYIadkivfykvlcltnVRKVFTALSQIIPGVLIYCI-----GYIDNVYIL 379
Cdd:cd17474 226 ELLYGISPIIIGLLFAGWSVLLALGSLFVGRL--------------LKKRFGARRILVIGLLLYALsllllGFVPSLALL 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 380 LTVWFIAVIFITASYAGAMANIIDLAPNYGHSAAVLAFCQTIHMSASfISPLTAGFIVtqedSIDQWRRVFEVSAIISIL 459
Cdd:cd17474 292 LIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQA-VGPLLFGLLL----EIFGLSAPFLVGAAIALA 366
|
....*...
gi 281366707 460 TYLFYQLF 467
Cdd:cd17474 367 AAVLLALL 374
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
36-243 |
2.04e-06 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 49.71 E-value: 2.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 36 RLVLYFLSWSGFLVSFMMRNDMNFALVAMIANdnstqnQSLIKSQ-QILGTgtddqktivksvvisSFYWCYVLSQVVGG 114
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLAD------LGLDKSDiGILGS---------------LFYITYGVSKFVSG 59
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 115 VATELFGTKCVFGWSQLATALCSFMMPSAAQLhyIAVIVLRSIQGFASGLTWPAMYAIVGYWIPLTERSRFMSSFQ-GFS 193
Cdd:cd17488 60 LMSDRSNPRYFMGIGLIATGIINILFGFSSSL--WAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNtSHN 137
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 281366707 194 IGIGLTYPLCGFILSEWGWPYIFYTTGTLglgwCILWYLLAFNTPREHPR 243
Cdd:cd17488 138 IGGALIPILTGFAALTYGWRAGMYVPGII----AILMGIVLCWRLRDRPP 183
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
96-436 |
2.76e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 49.47 E-value: 2.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 96 SVVISSFYWCYVLSQVVGGVATELFGTKCVFGWSQLATALCSFMMPSAAQlhYIAVIVLRSIQGFASGLTWPAMYAIVGY 175
Cdd:COG0738 46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS--YPLLLLALFLLGLGLGLLDVAANPYVAA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 176 WIPLTERSRfMSSFQGF-SIGiGLTYPLCG--FILSEWG--WPYIFYTTGTLGLGWCILWYLLAFntprehPRITKDEln 250
Cdd:COG0738 124 LGPETAASR-LNLLHAFfSLG-ALLGPLLGglLILLGLSlsWHLPYLILAVLLLLLALLFLRSKL------PEIEEEE-- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 251 yielnvkkevNSSVKVKVPWLQIFKSIPAWAIAITTFGRIFVHYIFIVNGPTFMGNVLKFNFETNGFLSGVPFICSYISS 330
Cdd:COG0738 194 ----------EEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 331 VLFCYIADKIVFYKVLcltnvrkvftALSQIIPGVLIYCIGYIDNVYilLTVWFIAVIFITAS--YAGAMANIIDLAPNy 408
Cdd:COG0738 264 FLGGFLLKRFGPVRLL----------RLSALLAAVGLLLALLAPGPW--LALIGLALVGLGLSlmFPTIFSLALDGLGK- 330
|
330 340
....*....|....*....|....*...
gi 281366707 409 gHSAAVLAFCQTIHMSASFISPLTAGFI 436
Cdd:COG0738 331 -RTAAAVSAVLIMGIVGGAIGPPLIGFL 357
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
105-468 |
4.57e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 48.72 E-value: 4.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 105 CYVLSQVVGGVATELFGTKCVFGWSQLATALCSFMMPSAAqlHYIAVIVLRSIQGFASGLTWPAMYAIVGYWIPltERSR 184
Cdd:COG2807 65 AFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP--SVALLLAGTALIGAGIAVGNVLLPGLIKRWFP--DRVG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 185 FMSSFQGFSIGIG------LTYPLcgfiLSEWGWPYIFYTTGTLGLGWCILWYLLAFNTPREHPRITKdelnyielnvkk 258
Cdd:COG2807 141 LMTGLYTAAMGLGaalaagLTVPL----AAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPA------------ 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 259 evnssvkvKVPWLQIFKSIPAWAIAITTFGRIFVHYIFIVNGPTFMGNvLKFNFETNGFLSGVPFICSYISSVLFCYIAD 338
Cdd:COG2807 205 --------AASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLAD 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 339 KivfykvlcLTNVRKVFTALSqiipgvLIYCIGYIDNVYILLTVWFIAVIFITASYAG----AMANIIDLAPNYGHSAAV 414
Cdd:COG2807 276 R--------LGDRRPLLLLLG------LLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGlfplALTLIGLRARTPAEAAAL 341
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 281366707 415 LAFCQTIHMSASFISPLTAGFIVTQEDSidqWRRVFEVSAIISILTYLFYQLFG 468
Cdd:COG2807 342 SGMAQSVGYLLAALGPLLVGALHDATGS---WTAALLLLAALAVLMLVAGLLAG 392
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
106-462 |
5.96e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 48.37 E-value: 5.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 106 YVLSQVVGGVATELFGTKCVFGWSQLATALCSFMMpsAAQLHYIAVIVLRSIQGFASGLTWPAMYAIVGYWIPLTERSR- 184
Cdd:cd17316 49 RPIGALLFGYLGDRIGRKKALILTLLLFGLATLLI--GLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFa 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 185 ----FMSSFQGFSIGIGLTYPLCGFILSEWGWPYIFYTTGTLGLgwcILWYLlafntpreHPRItkdelnyielnvkkev 260
Cdd:cd17316 127 lgllQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPAL---LALLL--------RRRT---------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 261 nssvkvkvpwlqifksipaWAIAITTFGRIFVHYIFIVNGPTFMGNVLKFNFETNGFLSGVPFICSYISSVLFCYIADKI 340
Cdd:cd17316 180 -------------------LLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 341 vfykvlcltnVRKVFTALSQIIPGVLIYCIGYI--DNVYILLTVWFIAVIFITASYAGAMANIIDLAPNYGHSAAVlAFC 418
Cdd:cd17316 241 ----------GRKKTLVIGLILSGILALPLFYLlsGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGV-GLS 309
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 281366707 419 QTIHMSASFISPLTAGFIVTQEDSIDQWRRVFEVSAIISILTYL 462
Cdd:cd17316 310 YNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
98-464 |
8.63e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.97 E-value: 8.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 98 VISSFYWCYVLSQVVGGVATELFGTKCVFGWSQLATALCSFMMPSAAQLhyIAVIVLRSIQGFASGLTWPAMYAIVGYWI 177
Cdd:cd17489 36 VVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSV--ALLLVLRLIHGIGWGAFTTAAATLVADII 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 178 PLTERSRFMSSFQ-GFSIGIGLTYPLCGFILSEWGWPYIFYTTGTLGLGWCILWYLLAFNTPREHPRITKDELNYIELNV 256
Cdd:cd17489 114 PPSRRGEGIGYYGlATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVE 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 257 KKEVNSSVkvkvpwLQIFKSIPAWAIaiTTFGRIFVHYIFIVNGptfmgnvlkfnfetnGFLSGVPFICSYISSVLFCYI 336
Cdd:cd17489 194 KKVLPPAL------ILFLASIAYGAI--STFLPLYAAERGISNA---------------GLFFTVYAIALLLSRPFSGKL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 337 ADKIVFYKVlcltnvrkvftalsqIIPGVLIYCIGYIdnvyILLTVWFIAVIFITASYAGA---------MANIIDLAPN 407
Cdd:cd17489 251 SDRKGPKTV---------------IIPGLLLLALGLL----LLSFAGSPWMLLLAAVLYGLgfgllfpalQALAVDLVPP 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 281366707 408 YGHSAAVLAFcqTIHMSASF-ISPLTAGFIVtqedSIDQWRRVFEVSAIISILTYLFY 464
Cdd:cd17489 312 HRRGAANGTF--FIFFDLGIgLGGLLLGLVA----ELFGYRAMFLLAAVVVLLALVLY 363
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
98-463 |
1.06e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 47.62 E-value: 1.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 98 VISSFYWCYVLSQVVGGVATELFGTKCVFGWSQLATALCSFMMpsAAQLHYIAVIVLRSIQGFASGLTWPAMYAIVGYWI 177
Cdd:cd17475 36 LLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLM--ALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 178 PLTERSRFMSSFQ-GFSIGIGLTYPLCGFILSEWGWPYIFYTTGTLGLGwCILWYLLAFNTPREHPRITKdelnyielnV 256
Cdd:cd17475 114 PPRERGLAMGIRQtGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSIL-AAVLFWLFYREPPAASAATE---------S 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 257 KKEVNSSVKvkvpwlQIFKSIPAWAIAITTFGRIFVHYIFIVNGPTFMGNVLKFNFETNGFLSGVPFICSYISSVLFCYI 336
Cdd:cd17475 184 ASTLLRSLK------EVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRV 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 337 ADKivfykvlCLTNVRKVFTALSQIIPGVLIYCIGYID---NVYILLTVWFIAVIFITASYAGAMANIIDLAPNyGHSAA 413
Cdd:cd17475 258 SDR-------VFGGRRRPVLVITAAIAAAALLVLSLLSpgtPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGP-EQAGT 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 281366707 414 VLAFCQTIHMSASFISPLTAGFIVtqeDSIDQWRRVFEVSAIISILTYLF 463
Cdd:cd17475 330 ALGLANTINFIGIAIGPPLFGLLV---DATHSYAPAWLALALLLVLAALL 376
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
111-217 |
1.55e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 47.17 E-value: 1.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 111 VVGGVATELFGTKCVFGWSQLATALCSFMM---PSAAQLhyiavIVLRSIQGFASGLTWPAMYAIVGYWIPLTERSR--- 184
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCalaPSLAFL-----IAARALQGIGAAAIMPASLALIAATFPGERRGRalg 123
|
90 100 110
....*....|....*....|....*....|...
gi 281366707 185 FMSSFQGFSIGIGLTypLCGFILSEWGWPYIFY 217
Cdd:cd17321 124 LWGAVVGIGAALGPL--LGGLLLELFGWRWIFL 154
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
124-436 |
3.56e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 46.07 E-value: 3.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 124 CVFGWSqLATALCSFMMpsaaqlHYIAVIVLRSIQGFASGLTWPAMYAIVGYWIPLTERSRFMSSFQ-GFSIGIGLTYPL 202
Cdd:cd17328 70 GILIWS-AATLLSSFAP------NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYfAIPLGSGLGYVV 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 203 CGFILSEW-GWPYIFYTTGTLGLGWCILWYLLAFNTPREHPRITKDELNYIElnvkkevnssvkvkvPWLQIFK-SIPAW 280
Cdd:cd17328 143 GGLVAQATgGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTAT---------------SFLADLKaLAKNP 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 281 AIAITTFGRIFVHYI---FIVNGPTFMGNVLKFNFETNGFLSGVPFICSYISSVLFCYIADKIVFYKVLCLTNVRKVFTA 357
Cdd:cd17328 208 SFILSTLGFTAVSFVtgaLAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCA 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 358 LSQI--IPGVLIYCIGYIDNVYILLTVWFIAVIFITASYAGAMANIIDLAPNYGHSAAVLAFCQTIHMSASFISPLTAGF 435
Cdd:cd17328 288 VGLLaaAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGL 367
|
.
gi 281366707 436 I 436
Cdd:cd17328 368 I 368
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
128-466 |
3.70e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.05 E-value: 3.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 128 WSQLATALCSFMMPSAAQLHYIA----VIVLRSIQGFASGLTWPAMYAIVGYWIP-LTERSRFMSSFQGFSIGIGLTYPL 202
Cdd:COG2211 86 IGAIPLALSFVLLFTAPDLSPTGkliyALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASV 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 203 CGFILSEW-------GWPYIFYTTGTLGLgwcILWYLLAFNTpREHPRITKDELNYIELnvkkevnssvkvkvpWLQIFK 275
Cdd:COG2211 166 LPPPLVAAfggdaalGYRLTALIFAVLGL---LAFLLTFFGT-KERPVPEEEKVSLKES---------------LKALLK 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 276 SIPAWAIAITTFGRIFVHYIFIVNGPTFMGNVLKFNFETNGFLSGVPFICSYISSVLFCYIADKIvfykvlcltNVRKVF 355
Cdd:COG2211 227 NRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRF---------GKKKAF 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 356 TAlsqiipGVLIYCIGYI-------DNVYILLTVWFIAVIFITASYAGAMANIIDLAPnYGHS----------AAVLAFC 418
Cdd:COG2211 298 II------GLLLAALGLLllfflgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVD-YDEWktgrrreglyFGIFTFA 370
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 281366707 419 QTIhmsASFISPLTAGFI---------VTQEDSIDQWRRVFE-----VSAIISILTYLFYQL 466
Cdd:COG2211 371 IKL---GQALAGALAGLLlalfgyvagAAQSPSALTGIRLLFfllpaVLLLLAALLLLFYPL 429
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
274-463 |
1.50e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.81 E-value: 1.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 274 FKSIPAWAIAITTFGRIFVHYIFIVNGPTFMGNvLKFNFETNGFLSGVPFICSYISSVLFCYIADKIvfykvlcltNVRK 353
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRF---------GRRR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 354 VFTAlsqiipGVLIYCIGYI-----DNVYILLTVWFIAVIFITASYAGAMANIIDLAPNyGHSAAVLAFCQTIHMSASFI 428
Cdd:COG2814 77 VLLL------GLLLFALGSLlcalaPSLWLLLAARFLQGLGAGALFPAALALIADLVPP-ERRGRALGLLGAGLGLGPAL 149
|
170 180 190
....*....|....*....|....*....|....*
gi 281366707 429 SPLTAGFIVTQEDsidqWRRVFEVSAIISILTYLF 463
Cdd:COG2814 150 GPLLGGLLADLFG----WRWVFLVNAVLALLALLL 180
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
96-239 |
1.57e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 44.09 E-value: 1.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 96 SVVISSFYWCYVLSQVVGGVATELFG--TKCVFGWSQLATALCSFMMPSAAQLhyIAVIVLRSIQGFASGLTWPAMYAIV 173
Cdd:COG2271 219 GLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSP--ALAIALLFLAGFGLGGAFGLLWALA 296
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 281366707 174 GYWIPLTERSRFMSSFQGFS-IGIGLTYPLCGFILSEWGWPYIFYTTGTLGLGWCILWYLLAFNTPR 239
Cdd:COG2271 297 AELFPKKARGTASGLVNTFGfLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
118-217 |
4.68e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 42.56 E-value: 4.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 118 ELFGTKCVFGWSQLATALCSFMM---PSAAQLhyiavIVLRSIQGFASGLTWPAMYAIVGYWIPLTERSRFMSSFqGFSI 194
Cdd:cd17503 56 DRFGTRRLFLTALALFTLGSLLCglaPNLASL-----IIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLV-GLVI 129
|
90 100
....*....|....*....|....*
gi 281366707 195 GIGLTY--PLCGFILSEWGWPYIFY 217
Cdd:cd17503 130 LLAPAIgpTLGGWLTDNLSWRWIFY 154
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
94-212 |
9.32e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 41.93 E-value: 9.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 94 VKSVVISSFYWCYVLSQVVGGVATELFGTKCVFGWSQLATALCSFMmpSAAQLHYIAVIVLRSIQGFASGLTWPAMYAIV 173
Cdd:TIGR00898 128 KVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVL--TAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLN 205
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 281366707 174 GYWIPLTERSRF-MSSFQGFSIGIgLTYPLCGFILSEWGW 212
Cdd:TIGR00898 206 TEFLPKKQRAIVgTLIQVFFSLGL-VLLPLVAYFIPDWRW 244
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
131-414 |
1.63e-03 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 40.69 E-value: 1.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 131 LATALCSFMMP--SAAQLHYIAVIVLRSIQGFASGLTWPAMYAIVGYWIPLTERSRFMSSFQ-GFSIGIGLTYPLCGFIL 207
Cdd:cd17345 76 ILSAIINILIGfvPSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNiSHNVGGGLVGPLAGLGL 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 208 SEWG---WPYIFYTTGTLGLGWCILWYLLAFNTPREH--PRI--TKDELNYIELNVKKEVNSSVKvKVPWLQIFKSIPAW 280
Cdd:cd17345 156 AIFGdgwWRGAFIFPAIIAIIVAVIVLFLGKDTPESEglPPIeeYKGDYPEEADGEEEEQELSAW-EIFVKYVLKNKLLW 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 281 AIAITTFGRIFVHYIFIVNGPTFMGNVLKFNFETNGFLSGVPFICSYISSVLFCYIADKivfykvlcLTNVRKVFTALSQ 360
Cdd:cd17345 235 YIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDK--------LFKGRRAPTGIIF 306
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 281366707 361 IIpGVLIYCIGY--IDNVYILLTVWFI--AVIFITASYAGAMAniIDLAPNYGHSAAV 414
Cdd:cd17345 307 MI-LVIVALIVYwlAPNVLVDLIALIAlgFLIYGPVMLIGLQA--LELVPKKAAGTAA 361
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
113-439 |
2.01e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 40.36 E-value: 2.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 113 GGVATELFGTKCVFGWS----QLATALCSFMMpsaaqlHYIAVIVLRSIQGFASGLTWPAMYAIVGYWIPLTERSRFMSS 188
Cdd:cd17371 54 GGILADRFGRVRVLVITillfAVFTLLCGFAQ------NYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGY 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 189 FQ-GFSIGIG----LTYPLCGFILSEWGWPYIFYttgtLGLGWCILWYLLAFNTPrEHPRITKdelnyielnvKKEVNSS 263
Cdd:cd17371 128 VQsGWAVGWLlatlLAALLFPLLPPEIAWRVLFL----LGALPALLVLFIRRFVK-EPPQWQA----------ARAARRH 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 264 VKVKVPWLQIFKSIPAWAIAITTFGRIFVH--YIFIVNG-PTFMGNVLKFNFETNGFLSGVPFICSYISSVLFCYIADKI 340
Cdd:cd17371 193 FADRPSLRELFSPPLLRTTLLASLLATGALggYYGITTWlPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRI 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 341 vfykvlcltnVRKVFTALSQIIPGVLIYCIGYIDNVYILLTVWFIAVIFITASYAGAMANIIDLAPNYGHSAAVLAFCQT 420
Cdd:cd17371 273 ----------GRRNNFALFALGSAISILLYFFLPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYN 342
|
330
....*....|....*....
gi 281366707 421 IHMSASFISPLTAGFIVTQ 439
Cdd:cd17371 343 VGRIIGALFPFLVGFLATS 361
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
107-391 |
3.03e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 39.90 E-value: 3.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 107 VLSQVVGGVATELFGTKCVFGWSQLATALCSFMMPSAAQLhyIAVIVLRSIQGFASGLTWPAMYAIVGYWIPLTERSRFM 186
Cdd:cd17329 49 IVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSP--WLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAF 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 187 SSF---QGFSIGIGltyPLCGFILSEWGWPYIFY-TTGTLGLGWCILWYLLAFNTPREHPRITKDelnyielnvkkevns 262
Cdd:cd17329 127 SLLywaINLGVAIG---PLLGGLLLLYSFRLLFLaAAVLFLLAALVLLFLLPETRPKRRAAEKTE--------------- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 263 svkVKVPWLQIFKSIPAWAIAITTFGRIFVHYIFIVNGPTFMGNVLKFNFETNGFLsgvpFICSYISSVLFCYIADKIVf 342
Cdd:cd17329 189 ---ILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLL----LALNALLIVLLQFPVARLV- 260
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 281366707 343 ykvlcltnvrKVFTALSQIIPGVLIYCIGYIDNVYIL-LTVWFIAVIFIT 391
Cdd:cd17329 261 ----------ERFRLRKILMIGILLFAIGFAVLAFANtLAVLILAMIVLT 300
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
107-437 |
7.09e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 38.88 E-value: 7.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 107 VLSQVVGGVATELFGTKCVFGWSQLATALcsFMMPSAAQLHYIAVIVLRSIQGFASGLTWPAMYAIVGYWIPLTERSRFM 186
Cdd:TIGR00895 66 AFGALFFGPLADRIGRRRVLLWSILLFSV--FTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAV 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 187 SS-FQGFSIGIGLTYPLCGFILSEWGWPYIFYTTGTLGLgwcILWYLLAFNTP-------REHPRITKDELNYIELNVKK 258
Cdd:TIGR00895 144 GLmFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPL---LLLLLLMRFLPesidflvSKRPETVRRIVNAIAPQMQA 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 259 EVNSSV--------KVKVPWLQIFKSIPAWA---IAITTFGRIFVHYIFIVNGPTFMGNvLKFNFETNGFLSGVPFICSY 327
Cdd:TIGR00895 221 EAQSALpeqkstqgTKRSVFKALFQGKTARItvlLWLLYFMLLVGVYFLTNWLPKLMVE-LGFSLSLAATGGALFNFGGV 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 328 ISSVLFCYIADKIvfykvlcltnVRKVFTALSQIIpGVLIYCIGY-IDNVYILLTVWFIAVIFITASYAGAMANIIDLAP 406
Cdd:TIGR00895 300 IGSIIFGWLADRL----------GPRVTALLLLLG-AVFAVLVGStLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYP 368
|
330 340 350
....*....|....*....|....*....|.
gi 281366707 407 NYGHSAAVlAFCQTIHMSASFISPLTAGFIV 437
Cdd:TIGR00895 369 TAIRATGV-GWAIGIGRLGAIIGPILAGYLL 398
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
96-439 |
8.33e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 38.46 E-value: 8.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 96 SVVISSFYWCYVLSQVVGGVATELFGTKCVFGWSQLATALCSFMMPSAAqlHYIAVIVLRSIQGFASGLTWPAMYAIVGY 175
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATP--SIYLFVVLMFLAGLGAGILDTGANTFVGA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 176 WIPltERSRFMSSFQGFSIGIG-LTYPLCG--FILSEWGWPYIFYTTGTLGLGWCILWYLLAFnTPREHPRITKDELNYI 252
Cdd:cd17333 112 LFE--ESSATRLNVLHGFFGLGaLIGPLIAtsLLTSELSWSWAYLIIGLIYLLLAILILLTLF-PELPSARNPQQSVGAF 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 253 ELNVKKEvnssvkvkvpwlqiFKSIPAWAIAITTFGRIFVHYIFIVNGPTFMGNVLKFNFETNGFLSGVPFICSYISSVL 332
Cdd:cd17333 189 SASASRL--------------LRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281366707 333 FCYIADKIVFYKVLCLTnvrkvftalsqiipgVLIYCIGYIDNVYILLTVWFIAVIFITASYAGAMANII--DLAPNYGH 410
Cdd:cd17333 255 GGPISRRIKPHTLLVLS---------------GSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTIlsLGISNLPY 319
|
330 340 350
....*....|....*....|....*....|
gi 281366707 411 SAA-VLAFCQTIHMSASFISPLTAGFIVTQ 439
Cdd:cd17333 320 AKGkGTSVLLAAGSIGGAIIPFIMGFIAEA 349
|
|
| |
