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Conserved domains on  [gi|164565381|ref|NP_001106834|]
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TBC1 domain family member 14 isoform b [Homo sapiens]

Protein Classification

TBC domain-containing protein( domain architecture ID 10640016)

TBC (Tre-2/Bub2/Cdc1) domain-containing protein may function as a GTPase activator protein of Rab-like small GTPases

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
118-350 7.96e-54

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


:

Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 178.27  E-value: 7.96e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164565381   118 WWQGIPPSVRGKVWSLAIGNElnithelfDICLARAKERWRSLstggsevENEDAGfsaaDREASLELIKLDISRTFPNL 197
Cdd:smart00164   1 VRKGVPPSLRGVVWKLLLNAQ--------PMDTSADKDLYSRL-------LKETAP----DDKSIVHQIEKDLRRTFPEH 61
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164565381   198 CIFQ-QGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNL-DTADAFIAFSNLLNKPCqMAFFRVDHGLMLTYFA 275
Cdd:smart00164  62 SFFQdKEGPGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVMeDEEDAFWCLVKLMERYG-PNFYLPDMSGLQLDLL 140
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 164565381   276 AFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKLFEDIL 350
Cdd:smart00164 141 QLDRLVKEYDPDLYKHLKDLGITPSLYALRWFLTLFARELPLEIVLRIWDVLFAEGSDFLFRVALALLKLHRDVL 215
 
Name Accession Description Interval E-value
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
118-350 7.96e-54

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 178.27  E-value: 7.96e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164565381   118 WWQGIPPSVRGKVWSLAIGNElnithelfDICLARAKERWRSLstggsevENEDAGfsaaDREASLELIKLDISRTFPNL 197
Cdd:smart00164   1 VRKGVPPSLRGVVWKLLLNAQ--------PMDTSADKDLYSRL-------LKETAP----DDKSIVHQIEKDLRRTFPEH 61
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164565381   198 CIFQ-QGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNL-DTADAFIAFSNLLNKPCqMAFFRVDHGLMLTYFA 275
Cdd:smart00164  62 SFFQdKEGPGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVMeDEEDAFWCLVKLMERYG-PNFYLPDMSGLQLDLL 140
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 164565381   276 AFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKLFEDIL 350
Cdd:smart00164 141 QLDRLVKEYDPDLYKHLKDLGITPSLYALRWFLTLFARELPLEIVLRIWDVLFAEGSDFLFRVALALLKLHRDVL 215
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
184-350 2.94e-50

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 167.43  E-value: 2.94e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164565381  184 ELIKLDISRTFPNlCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLIL-NLDTADAFIAFSNLLNKPCQMAF 262
Cdd:pfam00566  10 EQIEKDVPRTFPH-SFFFDNGPGQNSLRRILKAYSIYNPDVGYCQGMNFIAAPLLLvYLDEEDAFWCFVSLLENYLLRDF 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164565381  263 FRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWD-VFCRDGEEFLFRTALG 341
Cdd:pfam00566  89 YTPDFPGLKRDLYVFEELLKKKLPKLYKHLKELGLDPDLFASQWFLTLFAREFPLSTVLRIWDyFFLEGEKFVLFRVALA 168

                  ....*....
gi 164565381  342 ILKLFEDIL 350
Cdd:pfam00566 169 ILKRFREEL 177
COG5210 COG5210
GTPase-activating protein [General function prediction only];
29-355 1.96e-44

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 161.12  E-value: 1.96e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164565381  29 LSTTALILEDRPANLPAKPAEEAQKHrqqYEEMVVQAKKRELKEAQRRKKQLEERCRVEE------SIGNAVLTWNNEIL 102
Cdd:COG5210  115 SQSTSPELPKRLKDSLPTHLPEASST---EKDFSSFKGSSSLNSNPELNKEINELSLKEEpqklryYELAADKLWISYLD 191
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164565381 103 PNWE--TMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELnitheLFDICLARaKERWRSLstggseveNEDAGFSAADre 180
Cdd:COG5210  192 PNPLsfLPVQLSKLRELIRKGIPNELRGDVWEFLLGIGF-----DLDKNPGL-YERLLNL--------HREAKIPTQE-- 255
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164565381 181 aSLELIKLDISRTFPNLCIFQQGGPYH-DMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDT-ADAFIAFSNLL-NKP 257
Cdd:COG5210  256 -IISQIEKDLSRTFPDNSLFQTEISIRaENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVLESeEQAFWCLVKLLkNYG 334
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164565381 258 CQMAFFRVDHGLMLTYFAaFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFR 337
Cdd:COG5210  335 LPGYFLKNLSGLHRDLKV-LDDLVEELDPELYEHLLREGVVLLMFAFRWFLTLFVREFPLEYALRIWDCLFLEGSSMLFQ 413
                        330
                 ....*....|....*...
gi 164565381 338 TALGILKLFEDILTKMDF 355
Cdd:COG5210  414 LALAILKLLRDKLLKLDS 431
 
Name Accession Description Interval E-value
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
118-350 7.96e-54

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 178.27  E-value: 7.96e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164565381   118 WWQGIPPSVRGKVWSLAIGNElnithelfDICLARAKERWRSLstggsevENEDAGfsaaDREASLELIKLDISRTFPNL 197
Cdd:smart00164   1 VRKGVPPSLRGVVWKLLLNAQ--------PMDTSADKDLYSRL-------LKETAP----DDKSIVHQIEKDLRRTFPEH 61
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164565381   198 CIFQ-QGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNL-DTADAFIAFSNLLNKPCqMAFFRVDHGLMLTYFA 275
Cdd:smart00164  62 SFFQdKEGPGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVMeDEEDAFWCLVKLMERYG-PNFYLPDMSGLQLDLL 140
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 164565381   276 AFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFRTALGILKLFEDIL 350
Cdd:smart00164 141 QLDRLVKEYDPDLYKHLKDLGITPSLYALRWFLTLFARELPLEIVLRIWDVLFAEGSDFLFRVALALLKLHRDVL 215
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
184-350 2.94e-50

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 167.43  E-value: 2.94e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164565381  184 ELIKLDISRTFPNlCIFQQGGPYHDMLHSILGAYTCYRPDVGYVQGMSFIAAVLIL-NLDTADAFIAFSNLLNKPCQMAF 262
Cdd:pfam00566  10 EQIEKDVPRTFPH-SFFFDNGPGQNSLRRILKAYSIYNPDVGYCQGMNFIAAPLLLvYLDEEDAFWCFVSLLENYLLRDF 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164565381  263 FRVDHGLMLTYFAAFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWD-VFCRDGEEFLFRTALG 341
Cdd:pfam00566  89 YTPDFPGLKRDLYVFEELLKKKLPKLYKHLKELGLDPDLFASQWFLTLFAREFPLSTVLRIWDyFFLEGEKFVLFRVALA 168

                  ....*....
gi 164565381  342 ILKLFEDIL 350
Cdd:pfam00566 169 ILKRFREEL 177
COG5210 COG5210
GTPase-activating protein [General function prediction only];
29-355 1.96e-44

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 161.12  E-value: 1.96e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164565381  29 LSTTALILEDRPANLPAKPAEEAQKHrqqYEEMVVQAKKRELKEAQRRKKQLEERCRVEE------SIGNAVLTWNNEIL 102
Cdd:COG5210  115 SQSTSPELPKRLKDSLPTHLPEASST---EKDFSSFKGSSSLNSNPELNKEINELSLKEEpqklryYELAADKLWISYLD 191
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164565381 103 PNWE--TMWCSRKVRDLWWQGIPPSVRGKVWSLAIGNELnitheLFDICLARaKERWRSLstggseveNEDAGFSAADre 180
Cdd:COG5210  192 PNPLsfLPVQLSKLRELIRKGIPNELRGDVWEFLLGIGF-----DLDKNPGL-YERLLNL--------HREAKIPTQE-- 255
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164565381 181 aSLELIKLDISRTFPNLCIFQQGGPYH-DMLHSILGAYTCYRPDVGYVQGMSFIAAVLILNLDT-ADAFIAFSNLL-NKP 257
Cdd:COG5210  256 -IISQIEKDLSRTFPDNSLFQTEISIRaENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVLESeEQAFWCLVKLLkNYG 334
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164565381 258 CQMAFFRVDHGLMLTYFAaFEVFFEENLPKLFAHFKKNNLTPDIYLIDWIFTLYSKSLPLDLACRIWDVFCRDGEEFLFR 337
Cdd:COG5210  335 LPGYFLKNLSGLHRDLKV-LDDLVEELDPELYEHLLREGVVLLMFAFRWFLTLFVREFPLEYALRIWDCLFLEGSSMLFQ 413
                        330
                 ....*....|....*...
gi 164565381 338 TALGILKLFEDILTKMDF 355
Cdd:COG5210  414 LALAILKLLRDKLLKLDS 431
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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