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Conserved domains on  [gi|164607126|ref|NP_001106850|]
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transforming growth factor beta activator LRRC32 precursor [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 18077502)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 37-278 5.36e-28

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd00116:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 319  Bit Score: 114.76  E-value: 5.36e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126  37 HGLGLLQVPSVLS--LDIQALYLSGNQLQSI---LVSPLGFYTA---LRHLDLSDNQISFLQAGVFQAL---PYLEHLNL 105
Cdd:cd00116   36 GEEAAKALASALRpqPSLKELCLSLNETGRIprgLQSLLQGLTKgcgLQELDLSDNALGPDGCGVLESLlrsSSLQELKL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 106 AHNRLA-TGMALNSGGLGRLPL-LVSLDLSGNSLHGNLVERLLGE---TPRLRTLSLAENSLT-RLARHTFWGMPA---V 176
Cdd:cd00116  116 NNNGLGdRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALAKAlraNRDLKELNLANNGIGdAGIRALAEGLKAncnL 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 177 EQLDLHSNVLMDIEDGAF-EALPH---LTHLNLSRNSLT--CISDFSLQ------QLQVLDLSCNSIE--AFQTAPEPQA 242
Cdd:cd00116  196 EVLDLNNNGLTDEGASALaETLASlksLEVLNLGDNNLTdaGAAALASAllspniSLLTLSLSCNDITddGAKDLAEVLA 275

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 164607126 243 QF-QLAWLDLRENKL------LHFPDLAVF-PRLIYLNVSNNLI 278
Cdd:cd00116  276 EKeSLLELDLRGNKFgeegaqLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
126-548 2.46e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 2.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 126 LLVSLDLSGNSLHGNLVERLLGETPRLRTLSLAENSLTRLARHTFWGMPAVEQLDLHSNVLMDIEDGAFEALPHLTHLNL 205
Cdd:COG4886   24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 206 SRNSLTcisdFSLQQLQVLDLSCNSIEAFqtaPEPQAQF-QLAWLDLRENKLLHFPD-LAVFPRLIYLNVSNNLIQlpaG 283
Cdd:COG4886  104 SGNEEL----SNLTNLESLDLSGNQLTDL---PEELANLtNLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQLT---D 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 284 LPrgsedlhapsegwsaSPLSNpsrnasthpLSQLLNLDLSYNEIELVPASfLEHLTSLRFLNLSRNCLRSFEArQVDSL 363
Cdd:COG4886  174 LP---------------EELGN---------LTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPE-PLANL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 364 PCLVLLDLSHNVLEAL-ELGTkvLGSLQTLLLQDNALQELPPytFASLASLQRLNLQGNQVSPC---GGPAEPGPPGCVD 439
Cdd:COG4886  228 TNLETLDLSNNQLTDLpELGN--LTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLklkELELLLGLNSLLL 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 440 FSGIPTLHVLNMAGNSMGMLRAGSFLHTPLTELDLSTNPGLDVATGALVGLEASLEVLELQGNGLTVLRVDLPCFLRLKR 519
Cdd:COG4886  304 LLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383

                        410       420
                 ....*....|....*....|....*....
gi 164607126 520 LNLAENQLSHLPAWTRAVSLEVLDLRNNS 548
Cdd:COG4886  384 LLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 37-278 5.36e-28

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 114.76  E-value: 5.36e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126  37 HGLGLLQVPSVLS--LDIQALYLSGNQLQSI---LVSPLGFYTA---LRHLDLSDNQISFLQAGVFQAL---PYLEHLNL 105
Cdd:cd00116   36 GEEAAKALASALRpqPSLKELCLSLNETGRIprgLQSLLQGLTKgcgLQELDLSDNALGPDGCGVLESLlrsSSLQELKL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 106 AHNRLA-TGMALNSGGLGRLPL-LVSLDLSGNSLHGNLVERLLGE---TPRLRTLSLAENSLT-RLARHTFWGMPA---V 176
Cdd:cd00116  116 NNNGLGdRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALAKAlraNRDLKELNLANNGIGdAGIRALAEGLKAncnL 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 177 EQLDLHSNVLMDIEDGAF-EALPH---LTHLNLSRNSLT--CISDFSLQ------QLQVLDLSCNSIE--AFQTAPEPQA 242
Cdd:cd00116  196 EVLDLNNNGLTDEGASALaETLASlksLEVLNLGDNNLTdaGAAALASAllspniSLLTLSLSCNDITddGAKDLAEVLA 275

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 164607126 243 QF-QLAWLDLRENKL------LHFPDLAVF-PRLIYLNVSNNLI 278
Cdd:cd00116  276 EKeSLLELDLRGNKFgeegaqLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-344 3.58e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.13  E-value: 3.58e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126  51 DIQALYLSGNQLQSILVSpLGFYTALRHLDLSDNQISFLQAGVFQaLPYLEHLNLAHNRLATGmalnSGGLGRLPLLVSL 130
Cdd:COG4886  114 NLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEPLGN-LTNLKSLDLSNNQLTDL----PEELGNLTNLKEL 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 131 DLSGNSLhgNLVERLLGETPRLRTLSLAENSLTRLARhTFWGMPAVEQLDLHSNVLMDIEDgaFEALPHLTHLNLSRNSL 210
Cdd:COG4886  188 DLSNNQI--TDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 211 TCISD-FSLQQLQVLDLSCNSIEAFQTAPEPQAQFQLAWLDLRENKLLHFPDLAVFPRLIYLNVSNNLIQLPAGLPRGSE 289
Cdd:COG4886  263 TDLPPlANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 164607126 290 DLHAPSEGWSASPLSNPSRNASTHPLSQLLNLDLSYNEIELVPASFLEHLTSLRF 344
Cdd:COG4886  343 SLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
126-548 2.46e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 2.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 126 LLVSLDLSGNSLHGNLVERLLGETPRLRTLSLAENSLTRLARHTFWGMPAVEQLDLHSNVLMDIEDGAFEALPHLTHLNL 205
Cdd:COG4886   24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 206 SRNSLTcisdFSLQQLQVLDLSCNSIEAFqtaPEPQAQF-QLAWLDLRENKLLHFPD-LAVFPRLIYLNVSNNLIQlpaG 283
Cdd:COG4886  104 SGNEEL----SNLTNLESLDLSGNQLTDL---PEELANLtNLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQLT---D 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 284 LPrgsedlhapsegwsaSPLSNpsrnasthpLSQLLNLDLSYNEIELVPASfLEHLTSLRFLNLSRNCLRSFEArQVDSL 363
Cdd:COG4886  174 LP---------------EELGN---------LTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPE-PLANL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 364 PCLVLLDLSHNVLEAL-ELGTkvLGSLQTLLLQDNALQELPPytFASLASLQRLNLQGNQVSPC---GGPAEPGPPGCVD 439
Cdd:COG4886  228 TNLETLDLSNNQLTDLpELGN--LTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLklkELELLLGLNSLLL 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 440 FSGIPTLHVLNMAGNSMGMLRAGSFLHTPLTELDLSTNPGLDVATGALVGLEASLEVLELQGNGLTVLRVDLPCFLRLKR 519
Cdd:COG4886  304 LLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383

                        410       420
                 ....*....|....*....|....*....
gi 164607126 520 LNLAENQLSHLPAWTRAVSLEVLDLRNNS 548
Cdd:COG4886  384 LLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
17-317 1.39e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.43  E-value: 1.39e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126  17 AISQRREqvpCRTVNKEALC-HGLGLLQVPSVLSLDIQALYLSGNQLQSIlvsPLGFYTALRHLDLSDNQISFLQAgvfq 95
Cdd:PRK15370 168 AVQRMRD---CLKNNKTELRlKILGLTTIPACIPEQITTLILDNNELKSL---PENLQGNIKTLYANSNQLTSIPA---- 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126  96 ALP-YLEHLNLAHNRLatgMALNSgglgRLP-LLVSLDLSGNSLHGnLVERLLGEtprLRTLSLAENSLTRLARHtfwgM 173
Cdd:PRK15370 238 TLPdTIQEMELSINRI---TELPE----RLPsALQSLDLFHNKISC-LPENLPEE---LRYLSVYDNSIRTLPAH----L 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 174 PA-VEQLDLHSNVLMDIEdgafEALP-HLTHLNLSRNSLTCISDFSLQQLQVLDLSCNSIEAFQTAPEPqaqfQLAWLDL 251
Cdd:PRK15370 303 PSgITHLNVQSNSLTALP----ETLPpGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPETLPP----TITTLDV 374

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 164607126 252 RENKLLHFPDlAVFPRLIYLNVS-NNLIQLPAGLPrgsedlHAPSEGwsasplSNPSRNASTH-PLSQ 317
Cdd:PRK15370 375 SRNALTNLPE-NLPAALQIMQASrNNLVRLPESLP------HFRGEG------PQPTRIIVEYnPFSE 429
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 123-562 4.55e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.49  E-value: 4.55e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 123 RLPLLVSLDLSGNSLHGNLVERLLGETPRLRTLSLAENSLTRLARHTFwgMPAVEQLDLHSNVL---MDIEDGAFEAlph 199
Cdd:PLN00113  91 RLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLsgeIPNDIGSFSS--- 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 200 LTHLNLSRNSLTC---ISDFSLQQLQVLDLSCNSIEAfQTAPEPQAQFQLAWLDLRENKLL-HFPDlaVFPRLIYLN--- 272
Cdd:PLN00113 166 LKVLDLGGNVLVGkipNSLTNLTSLEFLTLASNQLVG-QIPRELGQMKSLKWIYLGYNNLSgEIPY--EIGGLTSLNhld 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 273 -VSNNLI-QLPAGLPRGSeDLHAPSegWSASPLSNPSRNaSTHPLSQLLNLDLSYNEIELVPASFLEHLTSLRFLNLSRN 350
Cdd:PLN00113 243 lVYNNLTgPIPSSLGNLK-NLQYLF--LYQNKLSGPIPP-SIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSN 318

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 351 CLRSFEARQVDSLPCLVLLDL--------------SHNVLEALELGTKVL-----------GSLQTLLLQDNALQELPPY 405
Cdd:PLN00113 319 NFTGKIPVALTSLPRLQVLQLwsnkfsgeipknlgKHNNLTVLDLSTNNLtgeipeglcssGNLFKLILFSNSLEGEIPK 398

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 406 TFASLASLQRLNLQGNQVS--PCGGPAEPGPPGCVDFSG-------------IPTLHVLNMAGNSMGMLRAGSFLHTPLT 470
Cdd:PLN00113 399 SLGACRSLRRVRLQDNSFSgeLPSEFTKLPLVYFLDISNnnlqgrinsrkwdMPSLQMLSLARNKFFGGLPDSFGSKRLE 478

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 471 ELDLSTNPGLDVATGALVGLeASLEVLELQGNGLT-VLRVDLPCFLRLKRLNLAENQLS-HLPA-WTRAVSLEVLDLRNN 547
Cdd:PLN00113 479 NLDLSRNQFSGAVPRKLGSL-SELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPAsFSEMPVLSQLDLSQN 557

                        490
                 ....*....|....*.
gi 164607126 548 SFS-LLPGNaMGGLET 562
Cdd:PLN00113 558 QLSgEIPKN-LGNVES 572
LRR_8 pfam13855
Leucine rich repeat;
150-210 9.98e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 9.98e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 164607126  150 PRLRTLSLAENSLTRLARHTFWGMPAVEQLDLHSNVLMDIEDGAFEALPHLTHLNLSRNSL 210
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 200-374 3.85e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.41  E-value: 3.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 200 LTHLNLSRNSLTCISDFSL-QQLQVLDLSCN---SIEAFQTAPepqaqfQLAWLDLRENKLLHFPDLAVFPRLIYLNVSN 275
Cdd:cd21340    4 ITHLYLNDKNITKIDNLSLcKNLKVLYLYDNkitKIENLEFLT------NLTHLYLQNNQIEKIENLENLVNLKKLYLGG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 276 NLIQLPAGL--PRGSEDLH------APSEGWSASPlsnpsrnASTHPLSQ-LLNLDLSYNEIELVpaSFLEHLTSLRFLN 346
Cdd:cd21340   78 NRISVVEGLenLTNLEELHienqrlPPGEKLTFDP-------RSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLD 148

                        170       180       190
                 ....*....|....*....|....*....|
gi 164607126 347 LSRNCLRSFE--ARQVDSLPCLVLLDLSHN 374
Cdd:cd21340  149 ASNNQISDLEelLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
316-376 3.22e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 3.22e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 164607126  316 SQLLNLDLSYNEIELVPASFLEHLTSLRFLNLSRNCLRSFEARQVDSLPCLVLLDLSHNVL 376
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 37-278 5.36e-28

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 114.76  E-value: 5.36e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126  37 HGLGLLQVPSVLS--LDIQALYLSGNQLQSI---LVSPLGFYTA---LRHLDLSDNQISFLQAGVFQAL---PYLEHLNL 105
Cdd:cd00116   36 GEEAAKALASALRpqPSLKELCLSLNETGRIprgLQSLLQGLTKgcgLQELDLSDNALGPDGCGVLESLlrsSSLQELKL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 106 AHNRLA-TGMALNSGGLGRLPL-LVSLDLSGNSLHGNLVERLLGE---TPRLRTLSLAENSLT-RLARHTFWGMPA---V 176
Cdd:cd00116  116 NNNGLGdRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALAKAlraNRDLKELNLANNGIGdAGIRALAEGLKAncnL 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 177 EQLDLHSNVLMDIEDGAF-EALPH---LTHLNLSRNSLT--CISDFSLQ------QLQVLDLSCNSIE--AFQTAPEPQA 242
Cdd:cd00116  196 EVLDLNNNGLTDEGASALaETLASlksLEVLNLGDNNLTdaGAAALASAllspniSLLTLSLSCNDITddGAKDLAEVLA 275

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 164607126 243 QF-QLAWLDLRENKL------LHFPDLAVF-PRLIYLNVSNNLI 278
Cdd:cd00116  276 EKeSLLELDLRGNKFgeegaqLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-344 3.58e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.13  E-value: 3.58e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126  51 DIQALYLSGNQLQSILVSpLGFYTALRHLDLSDNQISFLQAGVFQaLPYLEHLNLAHNRLATGmalnSGGLGRLPLLVSL 130
Cdd:COG4886  114 NLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEPLGN-LTNLKSLDLSNNQLTDL----PEELGNLTNLKEL 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 131 DLSGNSLhgNLVERLLGETPRLRTLSLAENSLTRLARhTFWGMPAVEQLDLHSNVLMDIEDgaFEALPHLTHLNLSRNSL 210
Cdd:COG4886  188 DLSNNQI--TDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQL 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 211 TCISD-FSLQQLQVLDLSCNSIEAFQTAPEPQAQFQLAWLDLRENKLLHFPDLAVFPRLIYLNVSNNLIQLPAGLPRGSE 289
Cdd:COG4886  263 TDLPPlANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 164607126 290 DLHAPSEGWSASPLSNPSRNASTHPLSQLLNLDLSYNEIELVPASFLEHLTSLRF 344
Cdd:COG4886  343 SLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
126-548 2.46e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 2.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 126 LLVSLDLSGNSLHGNLVERLLGETPRLRTLSLAENSLTRLARHTFWGMPAVEQLDLHSNVLMDIEDGAFEALPHLTHLNL 205
Cdd:COG4886   24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 206 SRNSLTcisdFSLQQLQVLDLSCNSIEAFqtaPEPQAQF-QLAWLDLRENKLLHFPD-LAVFPRLIYLNVSNNLIQlpaG 283
Cdd:COG4886  104 SGNEEL----SNLTNLESLDLSGNQLTDL---PEELANLtNLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQLT---D 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 284 LPrgsedlhapsegwsaSPLSNpsrnasthpLSQLLNLDLSYNEIELVPASfLEHLTSLRFLNLSRNCLRSFEArQVDSL 363
Cdd:COG4886  174 LP---------------EELGN---------LTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPE-PLANL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 364 PCLVLLDLSHNVLEAL-ELGTkvLGSLQTLLLQDNALQELPPytFASLASLQRLNLQGNQVSPC---GGPAEPGPPGCVD 439
Cdd:COG4886  228 TNLETLDLSNNQLTDLpELGN--LTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLklkELELLLGLNSLLL 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 440 FSGIPTLHVLNMAGNSMGMLRAGSFLHTPLTELDLSTNPGLDVATGALVGLEASLEVLELQGNGLTVLRVDLPCFLRLKR 519
Cdd:COG4886  304 LLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLA 383

                        410       420
                 ....*....|....*....|....*....
gi 164607126 520 LNLAENQLSHLPAWTRAVSLEVLDLRNNS 548
Cdd:COG4886  384 LLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
246-575 2.79e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 2.79e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 246 LAWLDLRENKLLHFPDLAVFPRLIYLNVSNNLIQLPAGLPRGSEDLHAPSEGWSASPLSNPSRNASTHPLSQLLNLDLSY 325
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 326 NEIELVPASFLEHLTSLRFLNLSRNclrsfeaRQVDSLPCLVLLDLSHNVLEALELGTKVLGSLQTLLLQDNALQELPPy 405
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 406 TFASLASLQRLNLQGNQVSPCGGpaepgppgcvDFSGIPTLHVLNMAGNSMgmlragSFLHTPLTELDlstnpgldvatg 485
Cdd:COG4886  154 PLGNLTNLKSLDLSNNQLTDLPE----------ELGNLTNLKELDLSNNQI------TDLPEPLGNLT------------ 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 486 alvgleaSLEVLELQGNGLTVLRVDLPCFLRLKRLNLAENQLSHLPAWTRAVSLEVLDLRNNSFSLLPGNamGGLeTSLR 565
Cdd:COG4886  206 -------NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPL--ANL-TNLK 275

                        330
                 ....*....|
gi 164607126 566 RLYLQGNPLS 575
Cdd:COG4886  276 TLDLSNNQLT 285
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
17-317 1.39e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.43  E-value: 1.39e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126  17 AISQRREqvpCRTVNKEALC-HGLGLLQVPSVLSLDIQALYLSGNQLQSIlvsPLGFYTALRHLDLSDNQISFLQAgvfq 95
Cdd:PRK15370 168 AVQRMRD---CLKNNKTELRlKILGLTTIPACIPEQITTLILDNNELKSL---PENLQGNIKTLYANSNQLTSIPA---- 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126  96 ALP-YLEHLNLAHNRLatgMALNSgglgRLP-LLVSLDLSGNSLHGnLVERLLGEtprLRTLSLAENSLTRLARHtfwgM 173
Cdd:PRK15370 238 TLPdTIQEMELSINRI---TELPE----RLPsALQSLDLFHNKISC-LPENLPEE---LRYLSVYDNSIRTLPAH----L 302

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 174 PA-VEQLDLHSNVLMDIEdgafEALP-HLTHLNLSRNSLTCISDFSLQQLQVLDLSCNSIEAFQTAPEPqaqfQLAWLDL 251
Cdd:PRK15370 303 PSgITHLNVQSNSLTALP----ETLPpGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPETLPP----TITTLDV 374

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 164607126 252 RENKLLHFPDlAVFPRLIYLNVS-NNLIQLPAGLPrgsedlHAPSEGwsasplSNPSRNASTH-PLSQ 317
Cdd:PRK15370 375 SRNALTNLPE-NLPAALQIMQASrNNLVRLPESLP------HFRGEG------PQPTRIIVEYnPFSE 429
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-278 3.17e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.36  E-value: 3.17e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126  39 LGLLQVPSVLSLDIQALYLSGNQLQSILVSPLGFYTALRHLDLSDNQISFLQAGVFQALPYLEHLNLAHNRlatgmalns 118
Cdd:COG4886   37 LLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE--------- 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 119 gGLGRLPLLVSLDLSGNSLhgNLVERLLGETPRLRTLSLAENSLTRLARhTFWGMPAVEQLDLHSNVLMDIeDGAFEALP 198
Cdd:COG4886  108 -ELSNLTNLESLDLSGNQL--TDLPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLT 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 199 HLTHLNLSRNSLTCISD--FSLQQLQVLDLSCNSIEAFqtaPEPQAQF-QLAWLDLRENKLLHFPDLAVFPRLIYLNVSN 275
Cdd:COG4886  183 NLKELDLSNNQITDLPEplGNLTNLEELDLSGNQLTDL---PEPLANLtNLETLDLSNNQLTDLPELGNLTNLEELDLSN 259


                 ...
gi 164607126 276 NLI 278
Cdd:COG4886  260 NQL 262
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 43-421 3.35e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 72.96  E-value: 3.35e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126  43 QVPSVLSL--DIQALYLSGNQLQSILVSPLGFYTALRHLDLSDNQISFLQAGVFQALPYLEHLNLAHNRLATGMALNSGG 120
Cdd:PLN00113 203 QIPRELGQmkSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFS 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 121 LGRLpllVSLDLSGNSLHGNLVErLLGETPRLRTLSLAENSLTRLARHTFWGMPAVEQLDLHSNVLMDIEDGAFEALPHL 200
Cdd:PLN00113 283 LQKL---ISLDLSDNSLSGEIPE-LVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNL 358

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 201 THLNLSRNSLT-------CISDfslqQLQVLDLSCNSIEAfQTAPEPQAQFQLAWLDLRENKLL-HFP-DLAVFPRLIYL 271
Cdd:PLN00113 359 TVLDLSTNNLTgeipeglCSSG----NLFKLILFSNSLEG-EIPKSLGACRSLRRVRLQDNSFSgELPsEFTKLPLVYFL 433

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 272 NVSNNLIQlpaglprGSEDlhapSEGWSASPLS--NPSRNASTHPL------SQLLNLDLSYNEI-ELVPASFLEhLTSL 342
Cdd:PLN00113 434 DISNNNLQ-------GRIN----SRKWDMPSLQmlSLARNKFFGGLpdsfgsKRLENLDLSRNQFsGAVPRKLGS-LSEL 501

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 343 RFLNLSRNCLRSFEARQVDSLPCLVLLDLSHNVLEA-LELGTKVLGSLQTLLLQDNALQELPPYTFASLASLQRLNLQGN 421
Cdd:PLN00113 502 MQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGqIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHN 581
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
112-379 6.49e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 72.04  E-value: 6.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 112 TGMALNSGGLGRLPL-----LVSLDLSGNSLHgNLVERLLGEtprLRTLSLAENSLTRLArhtfwgmpaveqldlhsnvl 186
Cdd:PRK15370 181 TELRLKILGLTTIPAcipeqITTLILDNNELK-SLPENLQGN---IKTLYANSNQLTSIP-------------------- 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 187 mdiedgafEALPH-LTHLNLSRNSLTCISDFSLQQLQVLDLSCNSIEAF-QTAPEpqaqfQLAWLDLRENKLLHFPdlAV 264
Cdd:PRK15370 237 --------ATLPDtIQEMELSINRITELPERLPSALQSLDLFHNKISCLpENLPE-----ELRYLSVYDNSIRTLP--AH 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 265 FPR-LIYLNV-SNNLIQLPAGLPRGSEDLHAPSEGWSASPLSNPsrnasthplSQLLNLDLSYNEIELVPASFLEHLTSl 342
Cdd:PRK15370 302 LPSgITHLNVqSNSLTALPETLPPGLKTLEAGENALTSLPASLP---------PELQVLDVSKNQITVLPETLPPTITT- 371

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 164607126 343 rfLNLSRNCLRSFEarqvDSLP-CLVLLDLSHNVLEAL 379
Cdd:PRK15370 372 --LDVSRNALTNLP----ENLPaALQIMQASRNNLVRL 403
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 52-211 1.47e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.50  E-value: 1.47e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126  52 IQALYLSGNQLQSIlvSPLGFYTALRHLDLSDNQISFLQagVFQALPYLEHLNLAHNRLATgmaLNsgGLGRLPLLVSLD 131
Cdd:cd21340   26 LKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISV---VE--GLENLTNLEELH 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 132 LSGNSLHGNL-----VERLLGETPRLRTLSLAENSLTRLArhTFWGMPAVEQLDLHSNVLMDIED--GAFEALPHLTHLN 204
Cdd:cd21340   97 IENQRLPPGEkltfdPRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELD 174


                 ....*..
gi 164607126 205 LSRNSLT 211
Cdd:cd21340  175 LTGNPVC 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 123-562 4.55e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 69.49  E-value: 4.55e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 123 RLPLLVSLDLSGNSLHGNLVERLLGETPRLRTLSLAENSLTRLARHTFwgMPAVEQLDLHSNVL---MDIEDGAFEAlph 199
Cdd:PLN00113  91 RLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNNMLsgeIPNDIGSFSS--- 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 200 LTHLNLSRNSLTC---ISDFSLQQLQVLDLSCNSIEAfQTAPEPQAQFQLAWLDLRENKLL-HFPDlaVFPRLIYLN--- 272
Cdd:PLN00113 166 LKVLDLGGNVLVGkipNSLTNLTSLEFLTLASNQLVG-QIPRELGQMKSLKWIYLGYNNLSgEIPY--EIGGLTSLNhld 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 273 -VSNNLI-QLPAGLPRGSeDLHAPSegWSASPLSNPSRNaSTHPLSQLLNLDLSYNEIELVPASFLEHLTSLRFLNLSRN 350
Cdd:PLN00113 243 lVYNNLTgPIPSSLGNLK-NLQYLF--LYQNKLSGPIPP-SIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSN 318

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 351 CLRSFEARQVDSLPCLVLLDL--------------SHNVLEALELGTKVL-----------GSLQTLLLQDNALQELPPY 405
Cdd:PLN00113 319 NFTGKIPVALTSLPRLQVLQLwsnkfsgeipknlgKHNNLTVLDLSTNNLtgeipeglcssGNLFKLILFSNSLEGEIPK 398

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 406 TFASLASLQRLNLQGNQVS--PCGGPAEPGPPGCVDFSG-------------IPTLHVLNMAGNSMGMLRAGSFLHTPLT 470
Cdd:PLN00113 399 SLGACRSLRRVRLQDNSFSgeLPSEFTKLPLVYFLDISNnnlqgrinsrkwdMPSLQMLSLARNKFFGGLPDSFGSKRLE 478

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 471 ELDLSTNPGLDVATGALVGLeASLEVLELQGNGLT-VLRVDLPCFLRLKRLNLAENQLS-HLPA-WTRAVSLEVLDLRNN 547
Cdd:PLN00113 479 NLDLSRNQFSGAVPRKLGSL-SELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPAsFSEMPVLSQLDLSQN 557

                        490
                 ....*....|....*.
gi 164607126 548 SFS-LLPGNaMGGLET 562
Cdd:PLN00113 558 QLSgEIPKN-LGNVES 572
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 46-477 6.02e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 66.02  E-value: 6.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126  46 SVLSLDIQALYLSGNQLQSILvsPLGFYTALRHLDLSDNQIS---FLQAGVFQALPYLEhlnLAHNRLaTGMALNSggLG 122
Cdd:PLN00113 114 FTTSSSLRYLNLSNNNFTGSI--PRGSIPNLETLDLSNNMLSgeiPNDIGSFSSLKVLD---LGGNVL-VGKIPNS--LT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 123 RLPLLVSLDLSGNSLHGNlVERLLGETPRLRTLSLAENSLTRLARHTFWGMPAVEQLDLHSNVLMDIEDGAFEALPHLTH 202
Cdd:PLN00113 186 NLTSLEFLTLASNQLVGQ-IPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQY 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 203 LNLSRNSLTCI---SDFSLQQLQVLDLSCNSIEAfqTAPEPQAQFQ-LAWLDLRENKLL-HFPD-LAVFPRLIYLNV-SN 275
Cdd:PLN00113 265 LFLYQNKLSGPippSIFSLQKLISLDLSDNSLSG--EIPELVIQLQnLEILHLFSNNFTgKIPVaLTSLPRLQVLQLwSN 342

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 276 NLI-QLPAGLPRGSE----DLhapsegwSASPLSN--PSRNASTHPLSQLLnldLSYNEIE-LVPASfLEHLTSLRFLNL 347
Cdd:PLN00113 343 KFSgEIPKNLGKHNNltvlDL-------STNNLTGeiPEGLCSSGNLFKLI---LFSNSLEgEIPKS-LGACRSLRRVRL 411

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 348 SRNCLRSFEARQVDSLPCLVLLDLSHN--------------VLEALELG-TKVLGSL---------QTLLLQDNALQELP 403
Cdd:PLN00113 412 QDNSFSGELPSEFTKLPLVYFLDISNNnlqgrinsrkwdmpSLQMLSLArNKFFGGLpdsfgskrlENLDLSRNQFSGAV 491

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 164607126 404 PYTFASLASLQRLNLQGNQVSPCGGPaepgppgcvDFSGIPTLHVLNMAGNSMGMLRAGSFLHTP-LTELDLSTN 477
Cdd:PLN00113 492 PRKLGSLSELMQLKLSENKLSGEIPD---------ELSSCKKLVSLDLSHNQLSGQIPASFSEMPvLSQLDLSQN 557
LRR_8 pfam13855
Leucine rich repeat;
150-210 9.98e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 9.98e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 164607126  150 PRLRTLSLAENSLTRLARHTFWGMPAVEQLDLHSNVLMDIEDGAFEALPHLTHLNLSRNSL 210
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 41-211 1.18e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 60.96  E-value: 1.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126  41 LLQVPSVLSLDIQALYLsGNQLQSILVSPLGFYTALRHLDLSDNQISflQAGV---FQALPY---LEHLNLAHNRL-ATG 113
Cdd:COG5238  204 LTQNTTVTTLWLKRNPI-GDEGAEILAEALKGNKSLTTLDLSNNQIG--DEGVialAEALKNnttVETLYLSGNQIgAEG 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 114 MALNSGGLGRLPLLVSLDLSGNSLHGNLVERL---LGETPRLRTLSLAENSLT-----RLARHtFWGMPAVEQLDLHSNV 185
Cdd:COG5238  281 AIALAKALQGNTTLTSLDLSVNRIGDEGAIALaegLQGNKTLHTLNLAYNGIGaqgaiALAKA-LQENTTLHSLDLSDNQ 359

                        170       180       190
                 ....*....|....*....|....*....|
gi 164607126 186 LMDIEDGAF----EALPHLTHLNLSRNSLT 211
Cdd:COG5238  360 IGDEGAIALakylEGNTTLRELNLGKNNIG 389
LRR_8 pfam13855
Leucine rich repeat;
76-137 2.42e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 2.42e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 164607126   76 LRHLDLSDNQISFLQAGVFQALPYLEHLNLAHNRLATgmaLNSGGLGRLPLLVSLDLSGNSL 137
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT---LSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-292 2.47e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 2.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126  52 IQALYLSGNQLQSIlVSPLGFYTALRHLDLSDNQISFLQAgVFQALPYLEHLNLAHNRLATgmalNSGGLGRLPLLVSLD 131
Cdd:COG4886  161 LKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTD----LPEPLANLTNLETLD 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 132 LSGN-----------------SLHGNLVERL--LGETPRLRTLSLAENSLTRLARHTFWGMPAVEQLDLHSNVLMDIEDG 192
Cdd:COG4886  235 LSNNqltdlpelgnltnleelDLSNNQLTDLppLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 193 AFEALPHLTHLNLSRNSLTCISDFSLQQLQVLDLSCNSIEAFQTAPEPQAQFQLAWLDLRENKLLHFPDLAVFPRLIYLN 272
Cdd:COG4886  315 ILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLL 394

                        250       260
                 ....*....|....*....|
gi 164607126 273 VSNNLIQLPAGLPRGSEDLH 292
Cdd:COG4886  395 TTTAGVLLLTLALLDAVNTE 414
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 200-374 3.85e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.41  E-value: 3.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 200 LTHLNLSRNSLTCISDFSL-QQLQVLDLSCN---SIEAFQTAPepqaqfQLAWLDLRENKLLHFPDLAVFPRLIYLNVSN 275
Cdd:cd21340    4 ITHLYLNDKNITKIDNLSLcKNLKVLYLYDNkitKIENLEFLT------NLTHLYLQNNQIEKIENLENLVNLKKLYLGG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 276 NLIQLPAGL--PRGSEDLH------APSEGWSASPlsnpsrnASTHPLSQ-LLNLDLSYNEIELVpaSFLEHLTSLRFLN 346
Cdd:cd21340   78 NRISVVEGLenLTNLEELHienqrlPPGEKLTFDP-------RSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLD 148

                        170       180       190
                 ....*....|....*....|....*....|
gi 164607126 347 LSRNCLRSFE--ARQVDSLPCLVLLDLSHN 374
Cdd:cd21340  149 ASNNQISDLEelLDLLSSWPSLRELDLTGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 151-575 7.35e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.01  E-value: 7.35e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 151 RLRTLSLAENSLTRLARHTFWGMPAVEQLDLHSNVLM-DIEDGAFEALPHLTHLNLSRNSLT-CISDFSLQQLQVLDLSC 228
Cdd:PLN00113  70 RVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLSN 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 229 NSIEAfQTAPEPQAQFQLAWLDLRENKLL-HFP-DLAVFPRLIYLNVSNNliQLPAGLPRgsEDLHAPSEGWSASPLSNP 306
Cdd:PLN00113 150 NMLSG-EIPNDIGSFSSLKVLDLGGNVLVgKIPnSLTNLTSLEFLTLASN--QLVGQIPR--ELGQMKSLKWIYLGYNNL 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 307 SRNASTH--PLSQLLNLDLSYNEIELVPASFLEHLTSLRFLNLSRNCLRSFEARQVDSLPCLVLLDLSHNVL--EALELG 382
Cdd:PLN00113 225 SGEIPYEigGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLsgEIPELV 304

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 383 TKvLGSLQTLLLQDNALQELPPYTFASLASLQRLNLQGNQVSpcggpaepgppgcvdfSGIPTlhvlnmagnSMGMlrag 462
Cdd:PLN00113 305 IQ-LQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFS----------------GEIPK---------NLGK---- 354

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 463 sflHTPLTELDLSTNPgldvATGALVgleaslEVLELQGNgltvlrvdlpcflrLKRLNLAENQL-SHLPAwtravslev 541
Cdd:PLN00113 355 ---HNNLTVLDLSTNN----LTGEIP------EGLCSSGN--------------LFKLILFSNSLeGEIPK--------- 398

                        410       420       430
                 ....*....|....*....|....*....|....
gi 164607126 542 ldlrnnsfSLlpgnamgGLETSLRRLYLQGNPLS 575
Cdd:PLN00113 399 --------SL-------GACRSLRRVRLQDNSFS 417
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 345-578 2.15e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.13  E-value: 2.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 345 LNLSRNCLRSFEARQV-DSLPCLVLLDLSHNVL--EALELGTKVL---GSLQTLLLQDNALQELPPYT------FASLAS 412
Cdd:cd00116    3 LSLKGELLKTERATELlPKLLCLQVLRLEGNTLgeEAAKALASALrpqPSLKELCLSLNETGRIPRGLqsllqgLTKGCG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 413 LQRLNLQGNQVSPCGGPAEPgppgcvDFSGIPTLHVLNMAGNSMG----MLRAGSFLHTP--LTELDLS----TNPGLDV 482
Cdd:cd00116   83 LQELDLSDNALGPDGCGVLE------SLLRSSSLQELKLNNNGLGdrglRLLAKGLKDLPpaLEKLVLGrnrlEGASCEA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 483 ATGALVGLeASLEVLELQGN-----GLTVLRVDLPCFLRLKRLNLAEN--------QLSHLPAWTRavSLEVLDLRNNSF 549
Cdd:cd00116  157 LAKALRAN-RDLKELNLANNgigdaGIRALAEGLKANCNLEVLDLNNNgltdegasALAETLASLK--SLEVLNLGDNNL 233

                        250       260       270
                 ....*....|....*....|....*....|...
gi 164607126 550 SLLP----GNAMGGLETSLRRLYLQGNPLSCCG 578
Cdd:cd00116  234 TDAGaaalASALLSPNISLLTLSLSCNDITDDG 266
LRR_8 pfam13855
Leucine rich repeat;
316-376 3.22e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 3.22e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 164607126  316 SQLLNLDLSYNEIELVPASFLEHLTSLRFLNLSRNCLRSFEARQVDSLPCLVLLDLSHNVL 376
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 388-553 5.30e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 5.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 388 SLQTLLLQDNALQELPPytFASLASLQRLNLQGNQVSPCGgpaepgppgcvDFSGIPTLHVLNMAGNSMGMLragSFLH- 466
Cdd:cd21340   25 NLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-----------NLENLVNLKKLYLGGNRISVV---EGLEn 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 467 -TPLTELDLS-----TNPGLDVATGALVGLEASLEVLELQGNGLTVLRvDLPCFLRLKRLNLAENQLSHLPAWTRAVS-- 538
Cdd:cd21340   89 lTNLEELHIEnqrlpPGEKLTFDPRSLAALSNSLRVLNISGNNIDSLE-PLAPLRNLEQLDASNNQISDLEELLDLLSsw 167

                        170
                 ....*....|....*..
gi 164607126 539 --LEVLDLRNNSFSLLP 553
Cdd:cd21340  168 psLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
55-110 1.92e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.92e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 164607126   55 LYLSGNQLQSILVSPLGFYTALRHLDLSDNQISFLQAGVFQALPYLEHLNLAHNRL 110
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
179-231 2.81e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 2.81e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 164607126  179 LDLHSNVLMDIEDGAFEALPHLTHLNLSRNSLTCISD---FSLQQLQVLDLSCNSI 231
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgafSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-167 6.06e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 6.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126  55 LYLSGNQLQSIlvSPLGFYTALRHLDLSDNQISFLQAgvFQALPYLEHLNLAHNRLATGMAL------------------ 116
Cdd:cd21340   51 LYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPGEKLtfdprslaalsnslrvln 126

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 164607126 117 -------NSGGLGRLPLLVSLDLSGNSLHG-NLVERLLGETPRLRTLSLAENSLTRLAR 167
Cdd:cd21340  127 isgnnidSLEPLAPLRNLEQLDASNNQISDlEELLDLLSSWPSLRELDLTGNPVCKKPK 185
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 313-543 1.72e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 1.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 313 HPLSQLLNLDLSYNEIELVPAsfLEHLTSLRFLNLSRNCLRSFEarQVDSLPCLVLLDLSHN---VLEALELgtkvLGSL 389
Cdd:cd21340   21 SLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNrisVVEGLEN----LTNL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 390 QTLLLQDNALQELPPYTF--ASLASLQrlnlqgnqvspcggpaepgppgcvdfsgiPTLHVLNMAGNSMGMLRAGSFLHT 467
Cdd:cd21340   93 EELHIENQRLPPGEKLTFdpRSLAALS-----------------------------NSLRVLNISGNNIDSLEPLAPLRN 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 468 pLTELDLSTNpgldvatgalvGLEASLEVLELqgngltvlrvdLPCFLRLKRLNLAENQLSHLPAW-----TRAVSLEVL 542
Cdd:cd21340  144 -LEQLDASNN-----------QISDLEELLDL-----------LSSWPSLRELDLTGNPVCKKPKYrdkiiLASKSLEVL 200


                 .
gi 164607126 543 D 543
Cdd:cd21340  201 D 201
LRR_8 pfam13855
Leucine rich repeat;
366-423 4.90e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 4.90e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 164607126  366 LVLLDLSHNVLEALELGT-KVLGSLQTLLLQDNALQELPPYTFASLASLQRLNLQGNQV 423
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
516-574 5.73e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 5.73e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 164607126  516 RLKRLNLAENQLSHLP--AWTRAVSLEVLDLRNNSFSLLPGNAMGGLeTSLRRLYLQGNPL 574
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
116-364 1.34e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.15  E-value: 1.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 116 LNSG--GLGRLPLLVSLDLSGNSLHGNLVERLLGETPRLRTLSLAENSLTRLARHTfwgmPAVEQLDLHSNVLMDIedga 193
Cdd:PRK15387 206 LNVGesGLTTLPDCLPAHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLPVLP----PGLLELSIFSNPLTHL---- 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 194 fEALPH-LTHLNLSRNSLTCISDF--SLQQLQVLDLSCNSIEAF------------QTAPEPQAQFQLAWLDLRENKLLH 258
Cdd:PRK15387 278 -PALPSgLCKLWIFGNQLTSLPVLppGLQELSVSDNQLASLPALpselcklwaynnQLTSLPTLPSGLQELSVSDNQLAS 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 259 FPDLavfPRLIY--LNVSNNLIQLPAgLPRGSEDLHAPSEGWSASP--------LSNPSRNASTHPL--SQLLNLDLSYN 326
Cdd:PRK15387 357 LPTL---PSELYklWAYNNRLTSLPA-LPSGLKELIVSGNRLTSLPvlpselkeLMVSGNRLTSLPMlpSGLLSLSVYRN 432

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 164607126 327 EIELVPASFLeHLTSLRFLNLSRNCL--RSFEA-RQVDSLP 364
Cdd:PRK15387 433 QLTRLPESLI-HLSSETTVNLEGNPLseRTLQAlREITSAP 472
PLN03150 PLN03150
hypothetical protein; Provisional
 96-163 2.05e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.42  E-value: 2.05e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 164607126  96 ALPYLEHLNLAHNRLATGMALNsggLGRLPLLVSLDLSGNSLHGNLVERlLGETPRLRTLSLAENSLT 163
Cdd:PLN03150 440 KLRHLQSINLSGNSIRGNIPPS---LGSITSLEVLDLSYNSFNGSIPES-LGQLTSLRILNLNGNSLS 503
PLN03150 PLN03150
hypothetical protein; Provisional
 497-575 4.00e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 4.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 497 LELQGNGLT-VLRVDLPCFLRLKRLNLAENQL-SHLPAWTRAV-SLEVLDLRNNSFSLLPGNAMGGLeTSLRRLYLQGNP 573
Cdd:PLN03150 423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIrGNIPPSLGSItSLEVLDLSYNSFNGSIPESLGQL-TSLRILNLNGNS 501


                 ..
gi 164607126 574 LS 575
Cdd:PLN03150 502 LS 503
PLN03150 PLN03150
hypothetical protein; Provisional
 345-424 6.46e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.88  E-value: 6.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126 345 LNLSRNCLRSFEARQVDSLPCLVLLDLSHNVLEA---LELGTkvLGSLQTLLLQDNALQELPPYTFASLASLQRLNLQGN 421
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGnipPSLGS--ITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGN 500


                 ...
gi 164607126 422 QVS 424
Cdd:PLN03150 501 SLS 503
LRR_8 pfam13855
Leucine rich repeat;
98-186 2.96e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164607126   98 PYLEHLNLAHNRLatgmalnsgglgrlpllvsLDLSGNSLHGNlverllgetPRLRTLSLAENSLTRLARHTFWGMPAVE 177
Cdd:pfam13855   1 PNLRSLDLSNNRL-------------------TSLDDGAFKGL---------SNLKVLDLSNNLLTTLSPGAFSGLPSLR 52


                  ....*....
gi 164607126  178 QLDLHSNVL 186
Cdd:pfam13855  53 YLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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