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Conserved domains on  [gi|193207406|ref|NP_001122871|]
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BTB domain-containing protein [Caenorhabditis elegans]

Protein Classification

potassium voltage-gated channel protein( domain architecture ID 13034531)

potassium voltage-gated channel protein similar to Caenorhabditis elegans probable voltage-gated potassium channel subunit kvs-4 that mediates transmembrane potassium transport in excitable membranes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 280-498 2.26e-27

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 110.05  E-value: 2.26e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  280 DFVYKPTDSPNLPLTILEYICIGWFTFEYLVRFTIYPRKRQFVKKTLNIIDLSTILPFYLEICLplfgvesrlkEFTGIT 359
Cdd:pfam00520  22 ETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKRYFRSPWNILDFVVVLPSLISLVL----------SSVGSL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  360 SGWPFLGAMlvvrvlrvlRMARVFKLARYSTSLQTFGHTLQSSITELSMLSMFLITGIVFFSTIMYYLEK---------D 430
Cdd:pfam00520  92 SGLRVLRLL---------RLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGgklktwenpD 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 193207406  431 EPHTDFYSIPAGCWWCVVTMATVGYGDAKPVTTLGK-------LVATSTSICGIIVLAFPISMIVEKFATAQQRA 498
Cdd:pfam00520 163 NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayiYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
BTB_POZ_Kv cd18317
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 65-153 3.05e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.


:

Pssm-ID: 349626  Cd Length: 82  Bit Score: 104.61  E-value: 3.05e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  65 MRLNVGGKSYYVRAELYTSE-WTRMHELLDSSHEerlkmvdgFDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQNVCVE 143
Cdd:cd18317    1 VVLNVGGTRFELSRSTLLRFpDTRLGKLAKESHA--------YDESTNEYFFDRNPEVFEAILDYYRTGELHLPSNVCPA 72

                         90
                 ....*....|
gi 193207406 144 RFKEELEYWK 153
Cdd:cd18317   73 SFKEELEFWG 82
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 280-498 2.26e-27

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 110.05  E-value: 2.26e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  280 DFVYKPTDSPNLPLTILEYICIGWFTFEYLVRFTIYPRKRQFVKKTLNIIDLSTILPFYLEICLplfgvesrlkEFTGIT 359
Cdd:pfam00520  22 ETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKRYFRSPWNILDFVVVLPSLISLVL----------SSVGSL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  360 SGWPFLGAMlvvrvlrvlRMARVFKLARYSTSLQTFGHTLQSSITELSMLSMFLITGIVFFSTIMYYLEK---------D 430
Cdd:pfam00520  92 SGLRVLRLL---------RLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGgklktwenpD 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 193207406  431 EPHTDFYSIPAGCWWCVVTMATVGYGDAKPVTTLGK-------LVATSTSICGIIVLAFPISMIVEKFATAQQRA 498
Cdd:pfam00520 163 NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayiYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
BTB_POZ_Kv cd18317
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 65-153 3.05e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.


Pssm-ID: 349626  Cd Length: 82  Bit Score: 104.61  E-value: 3.05e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  65 MRLNVGGKSYYVRAELYTSE-WTRMHELLDSSHEerlkmvdgFDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQNVCVE 143
Cdd:cd18317    1 VVLNVGGTRFELSRSTLLRFpDTRLGKLAKESHA--------YDESTNEYFFDRNPEVFEAILDYYRTGELHLPSNVCPA 72

                         90
                 ....*....|
gi 193207406 144 RFKEELEYWK 153
Cdd:cd18317   73 SFKEELEFWG 82
BTB_2 pfam02214
BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific ...
 66-162 2.18e-15

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.


Pssm-ID: 426665 [Multi-domain]  Cd Length: 93  Bit Score: 71.47  E-value: 2.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406   66 RLNVGGKsyyvRAELYTSEWTRMHELLDSSHEERLkmVDGFDSKTGEYYLERNAKLTDHVMDFFVT-GSLHKPQNVCVER 144
Cdd:pfam02214   2 KLNVGGT----RFETLKSTLTRFPDTRLGRLLELE--CDDYDDDTNEYFFDRSPKHFETILNFYRTgGKLHRPEEVCLDE 75

                          90
                  ....*....|....*...
gi 193207406  145 FKEELEYWKIKPDQLSTC 162
Cdd:pfam02214  76 FLEEAEFYGLDELALELC 93
PRK10537 PRK10537
voltage-gated potassium channel protein;
401-488 3.63e-07

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 52.33  E-value: 3.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406 401 SSITELSMLSMFLITGIVFFSTIMYYLEKDEPHTDFYSIPAGCWWCVVTMATVGYGDAKPVTTLGKLVATSTSICGIIVL 480
Cdd:PRK10537 131 SSLAAGTLFAVISITSLLFYSTFGALYLGDGFSPPIESLSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVF 210


                 ....*...
gi 193207406 481 AFPISMIV 488
Cdd:PRK10537 211 ATSISAIF 218
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 64-165 8.96e-07

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 47.30  E-value: 8.96e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406    64 YMRLNVGGKSYYVRAELYTSEWTRMHELLDSSHEErlkmvdgfDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQNvCVE 143
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKE--------SDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEE-NVE 71

                           90       100
                   ....*....|....*....|..
gi 193207406   144 RFKEELEYWKIKPDQLSTCCQI 165
Cdd:smart00225  72 ELLELADYLQIPGLVELCEEFL 93
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 280-498 2.26e-27

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 110.05  E-value: 2.26e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  280 DFVYKPTDSPNLPLTILEYICIGWFTFEYLVRFTIYPRKRQFVKKTLNIIDLSTILPFYLEICLplfgvesrlkEFTGIT 359
Cdd:pfam00520  22 ETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKRYFRSPWNILDFVVVLPSLISLVL----------SSVGSL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  360 SGWPFLGAMlvvrvlrvlRMARVFKLARYSTSLQTFGHTLQSSITELSMLSMFLITGIVFFSTIMYYLEK---------D 430
Cdd:pfam00520  92 SGLRVLRLL---------RLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGgklktwenpD 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 193207406  431 EPHTDFYSIPAGCWWCVVTMATVGYGDAKPVTTLGK-------LVATSTSICGIIVLAFPISMIVEKFATAQQRA 498
Cdd:pfam00520 163 NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayiYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
BTB_POZ_Kv cd18317
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 65-153 3.05e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.


Pssm-ID: 349626  Cd Length: 82  Bit Score: 104.61  E-value: 3.05e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  65 MRLNVGGKSYYVRAELYTSE-WTRMHELLDSSHEerlkmvdgFDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQNVCVE 143
Cdd:cd18317    1 VVLNVGGTRFELSRSTLLRFpDTRLGKLAKESHA--------YDESTNEYFFDRNPEVFEAILDYYRTGELHLPSNVCPA 72

                         90
                 ....*....|
gi 193207406 144 RFKEELEYWK 153
Cdd:cd18317   73 SFKEELEFWG 82
BTB_POZ_Kv2_KCNB cd18378
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 66-164 1.24e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNB/Kv2 subfamily of Shab-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains two alpha subunit members, Kv2.1 (KCNB1) and Kv2.2 (KCNB2), which are orthologs of the Shab gene in Drosophila. They are delayed-rectifier potassium currents in various neurons, although their physiological roles often remain elusive. Kv2/KCNB subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349687 [Multi-domain]  Cd Length: 109  Bit Score: 78.59  E-value: 1.24e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  66 RLNVGGKSYYVR----AELYTSEWTRMHELldSSHEERLKMVDGFDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQNVC 141
Cdd:cd18378    5 LLNVGGVRHEVLwrtlDRLPRTRLGRLREC--NTHESLLELCDDYDLEDNEYFFDRHPGAFTSILNFYRTGKLHMPEEMC 82

                         90       100
                 ....*....|....*....|...
gi 193207406 142 VERFKEELEYWKIKPDQLSTCCQ 164
Cdd:cd18378   83 VLSFSQELEYWGIDEIYLESCCQ 105
BTB_POZ_Kv3_KCNC cd18379
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 65-170 1.99e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNC/Kv3 subfamily of Shaw-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains four alpha subunit members, Kv3.1 (KCNC1), Kv3.2 (KCNC2), Kv3.3 (KCNC3), and Kv3.4 (KCNC4), which are orthologs of the Shaw gene in Drosophila. Unlike other Kv subfamilies, Kv3 channels typically open only at positive potentials and both, activation and deactivation, in response to changes in voltage are very rapid. They are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. Kv3/KCNC subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349688 [Multi-domain]  Cd Length: 109  Bit Score: 75.12  E-value: 1.99e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  65 MRLNVGGksyyVRAELYTSEW-----TRMHELLDSSHeerlKMVDgFDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQN 139
Cdd:cd18379    1 IVINVGG----VRHETYKSTLrnlpdTRLAWLTETEA----SAFD-YDPVTGEFFFDRHPGVFAQILNYYRTGKLHCPAD 71

                         90       100       110
                 ....*....|....*....|....*....|.
gi 193207406 140 VCVERFKEELEYWKIKPDQLSTCCQIPSEHH 170
Cdd:cd18379   72 VCGPLFEEELAFWGIDETQIEPCCWMTYRQH 102
BTB_2 pfam02214
BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific ...
 66-162 2.18e-15

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.


Pssm-ID: 426665 [Multi-domain]  Cd Length: 93  Bit Score: 71.47  E-value: 2.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406   66 RLNVGGKsyyvRAELYTSEWTRMHELLDSSHEERLkmVDGFDSKTGEYYLERNAKLTDHVMDFFVT-GSLHKPQNVCVER 144
Cdd:pfam02214   2 KLNVGGT----RFETLKSTLTRFPDTRLGRLLELE--CDDYDDDTNEYFFDRSPKHFETILNFYRTgGKLHRPEEVCLDE 75

                          90
                  ....*....|....*...
gi 193207406  145 FKEELEYWKIKPDQLSTC 162
Cdd:pfam02214  76 FLEEAEFYGLDELALELC 93
BTB_POZ_KCNS3 cd18428
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 65-163 1.26e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3); KCNS3, also called delayed-rectifier K(+) channel alpha subunit 3 or voltage-gated potassium channel subunit Kv9.3, is an alpha subunit of voltage-gated potassium channel linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS3 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349735  Cd Length: 108  Bit Score: 69.87  E-value: 1.26e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  65 MRLNVGG-KSYYVRAELYTSEWTRMHELLDSSHEER-LKMVDGFDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQNVCV 142
Cdd:cd18428    3 INLNVGGfKQSVDQSTLLRFPHTRLGKLLNCHSEEAiLELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCV 82

                         90       100
                 ....*....|....*....|.
gi 193207406 143 ERFKEELEYWKIKPDQLSTCC 163
Cdd:cd18428   83 FSFCQEIEYWGINELFIDSCC 103
BTB_POZ_Kv4_KCND cd18380
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 65-164 2.16e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCND/Kv4 subfamily of Shal-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv4, also known as subfamily D, contains three alpha subunit members, Kv4.1 (KCND1), Kv4.2 (KCND2), and Kv4.3 (KCND3), which are orthologs of the Shal gene in Drosophila. They are A-type potassium channels that mediate the native, fast inactivating (A-type) K+ current (IA) described both in the nervous system (A currents) and the heart (transient outward current). Kv4/KCND subfamily alpha subunits form functional homo- or hetero-tetrameric channels through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. They are modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349689 [Multi-domain]  Cd Length: 102  Bit Score: 68.93  E-value: 2.16e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  65 MRLNVGGksyyVRAELYTSEWTRMHE-LLDSSHEERLkmvdgFDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQNVCVE 143
Cdd:cd18380    2 IVINVSG----RRFETWKNTLEKYPDtLLGSTEKEFF-----YDDDTKEYFFDRDPEIFRHILNFYRTGKLHYPRHECIS 72

                         90       100
                 ....*....|....*....|.
gi 193207406 144 RFKEELEYWKIKPDQLSTCCQ 164
Cdd:cd18380   73 AYDDELAFFGILPEIIGDCCY 93
BTB_POZ_KCND1 cd18417
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-163 6.99e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 1 (KCND1); KCND1, also called voltage-gated potassium channel subunit Kv4.1, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. It may contribute to I (To) current in heart and I (Sa) current in neurons. Its properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349724 [Multi-domain]  Cd Length: 138  Bit Score: 68.83  E-value: 6.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  27 AAVQAASMERRVAFRPPPIGESRSttithdsgsnaDTYMRLNVGGKsyyvRAELYTSEWTRMHE-LLDSSHEERLkmvdg 105
Cdd:cd18417   10 AAVGWLPLAKKPMPKPPSDKKRRN-----------DEILVVNVSGR----RFQTWKNTLDRYPDtLLGSSEKEFF----- 69

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 193207406 106 FDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQNVCVERFKEELEYWKIKPDQLSTCC 163
Cdd:cd18417   70 YNEDTQEYFFDRDPEMFRHILNFYRTGRLHYPRHECIQAFDEELSFYGIIPEIIGDCC 127
BTB_POZ_KCNS2 cd18427
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 65-163 9.48e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 2 (KCNS2); KCNS2, also called delayed-rectifier K(+) channel alpha subunit 2 or voltage-gated potassium channel subunit Kv9.2, is a modulatory alpha subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349734  Cd Length: 107  Bit Score: 67.57  E-value: 9.48e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  65 MRLNVGGKSYYVRAE-LYTSEWTRMHELLD-SSHEERLKMVDGFDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQNVCV 142
Cdd:cd18427    2 ISINVGGFKKRLRSHtLLRFPETRLGRLLScRSKESILELCDDYDDTKNEFYFDRNPELFPYVLHFYNTGKLHVMGELCV 81

                         90       100
                 ....*....|....*....|.
gi 193207406 143 ERFKEELEYWKIKPDQLSTCC 163
Cdd:cd18427   82 FSFSQEIEYWGINEFFIDSCC 102
BTB_POZ_KCNS1 cd18426
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 65-163 1.26e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 1 (KCNS1); KCNS1, also called delayed-rectifier K(+) channel alpha subunit 1 or voltage-gated potassium channel subunit Kv9.1, is a modulatory alpha subunit of voltage-gated potassium channel that mediates neuropathic pain following nerve injury. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349733 [Multi-domain]  Cd Length: 106  Bit Score: 67.22  E-value: 1.26e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  65 MRLNVGG-KSYYVRAELYTSEWTRMHELLDSSHEER-LKMVDGFDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQNVCV 142
Cdd:cd18426    1 ININVGGlKRRLSSSTLSKFPDTRLGRLLSCDSEESiLQICDDYDVSAKEFYFDRNPGLFPYVLHFYQTGKLHIMEELCV 80

                         90       100
                 ....*....|....*....|.
gi 193207406 143 ERFKEELEYWKIKPDQLSTCC 163
Cdd:cd18426   81 FSFSQEIEYWGINEFFLDSCC 101
BTB_Shaw-like cd18416
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-170 4.33e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw; Shaw, also called Shaw2, is a voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaw is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349723 [Multi-domain]  Cd Length: 112  Bit Score: 65.75  E-value: 4.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  67 LNVGGksyyVRAELYTSEW-----TRMHELLDSsheerlkmVDGFDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQNVC 141
Cdd:cd18416    6 LNVGG----IRHETYKATLkkipaTRLSRLTEA--------LANYDPVLNEYFFDRHPGVFAQILNYYRTGKLHYPTDVC 73

                         90       100
                 ....*....|....*....|....*....
gi 193207406 142 VERFKEELEYWKIKPDQLSTCCQIPSEHH 170
Cdd:cd18416   74 GPLFEEELEFWGLDANQVEPCCWMTYTAH 102
BTB_POZ_KCNV1 cd18424
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-164 6.29e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 1 (KCNV1); KCNV1, also called neuronal potassium channel alpha subunit HNKA or voltage-gated potassium channel subunit Kv8.1, is a new neuronal voltage-gated potassium channel alpha subunit with specific inhibitory properties towards Shab and Shaw channels. It modulates KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2) channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. It can also down-regulate the channel activity of KCNB1, KCNB2, KCNC4 (also known as Kv3.4) and KCND1 (also known as Kv4.1), possibly by trapping them in intracellular membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349731  Cd Length: 109  Bit Score: 65.22  E-value: 6.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  67 LNVGGKSYYVRAELYTSE-WTRMHELLDSSHEERLKMVDGFDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQNVCVERF 145
Cdd:cd18424    3 INVGGSRFVLSQQVLSSHpETRLGKLAVSVRDSVLELCDDANFVDNEYFFDRSSQAFKYIMNYYKTGHLHVMEELCAISF 82

                         90
                 ....*....|....*....
gi 193207406 146 KEELEYWKIKPDQLSTCCQ 164
Cdd:cd18424   83 LQEIEYWGIDELSIDSCCR 101
BTB_KCNC1_3 cd18414
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-170 1.51e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3; KCNC1 (also called NGK2, voltage-gated potassium channel subunit Kv3.1, or voltage-gated potassium channel subunit Kv4) and KCNC3 (also called KSHIIID or voltage-gated potassium channel subunit Kv3.3) play important roles in the rapid repolarization of fast-firing brain neurons. Assuming opened or closed conformations in response to the voltage difference across the membrane, the proteins form tetrameric potassium-selective channels through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC1 and KCNC3 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349721 [Multi-domain]  Cd Length: 117  Bit Score: 64.21  E-value: 1.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  67 LNVGG-KSYYVRAELYTSEWTRMHELLDSSHEERLKmvdgFDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQNVCVERF 145
Cdd:cd18414    7 INVGGtRHETYRSTLRTLPGTRLAWLAEPDAHSNFD----YDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLY 82

                         90       100
                 ....*....|....*....|....*
gi 193207406 146 KEELEYWKIKPDQLSTCCQIPSEHH 170
Cdd:cd18414   83 EEELAFWGIDETDVEPCCWMTYRQH 107
BTB_POZ_Shab-like cd18413
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-164 1.56e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shab and similar proteins; Shab is a slow delayed rectifier voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shab is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349720 [Multi-domain]  Cd Length: 109  Bit Score: 64.13  E-value: 1.56e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  67 LNVGGKSYYVR-AELYTSEWTRMHELLDS-SHEERLKMVDGFDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQNVCVER 144
Cdd:cd18413    6 INVGGVKHEVLwRTLDRMPHTRLGKLRDSnTHEAIVELCDDYSLADNEYFFDRHPRSFASILNFYRTGKLHLVEEMCVLA 85

                         90       100
                 ....*....|....*....|
gi 193207406 145 FKEELEYWKIKPDQLSTCCQ 164
Cdd:cd18413   86 FSDDLEYWGVDELYLESCCQ 105
BTB_POZ_Shal-like cd18420
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-163 1.87e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster potassium voltage-gated channel protein Shal and similar proteins; Drosophila melanogaster Shal, also called Shaker cognate l or Shal2, is a transient potassium current (I(A)) channel, which is required for maintaining excitability during repetitive firing and normal locomotion in Drosophila. It may play a role in the nervous system and in the regulation of beating frequency in pacemaker cells. Shal mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shal is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349727 [Multi-domain]  Cd Length: 139  Bit Score: 64.87  E-value: 1.87e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  42 PPPIGESRSTTithdsgsnADTYMRLNVGGKsyyvRAELYTSEWTRMHELLDSSHEERLKmvdgFDSKTGEYYLERNAKL 121
Cdd:cd18420   23 PPPVDQERRRT--------DDEKLIINVSGR----RFETWRNTLEKYPDTLLGSNEREFF----YDEETKEYFFDRDPDI 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 193207406 122 TDHVMDFFVTGSLHKPQNVCVERFKEELEYWKIKPDQLSTCC 163
Cdd:cd18420   87 FRHILNYYRTGKLHYPKHECLTAYDEELAFFGIMPDIIGDCC 128
BTB_POZ_Kv9_KCNS cd18384
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 65-163 2.02e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNS/Kv9 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv9, also known as subfamily S, includes KCNS1 (Kv9.1), KCNS2 (Kv9.2) and KCNS3 (Kv9.3). They are regulatory alpha subunits that cannot form functional homo-tetrameric channels. Both KCNS1 and KCNS2 are delayed-rectifier K(+) channel alpha subunits that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. KCNS3 is a delayed-rectifier K(+) channel alpha subunit linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.


Pssm-ID: 349692  Cd Length: 106  Bit Score: 63.70  E-value: 2.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  65 MRLNVGGKSYYVRAE-LYTSEWTRMHELLDSSHEER-LKMVDGFDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQNVCV 142
Cdd:cd18384    1 IRINVGGFRRRLSASaLLRFPGTRLGRLLACHSEEAiLELCDDYDVAAREFYFDRNPGFFLYVLHFYRTGKLHVMDELCV 80

                         90       100
                 ....*....|....*....|.
gi 193207406 143 ERFKEELEYWKIKPDQLSTCC 163
Cdd:cd18384   81 FSFSQEIEYWGINEFFLDSCC 101
BTB_POZ_KCNB2 cd18412
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-173 2.60e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 2 (KCNB2); KCNB2, also called voltage-gated potassium channel subunit Kv2.2, mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB2 contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349719 [Multi-domain]  Cd Length: 127  Bit Score: 63.87  E-value: 2.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  42 PPPIGESRSTTITHDsgsnadtyMRLNVGGKSYYVR-AELYTSEWTRMHELLD-SSHEERLKMVDGFDSKTGEYYLERNA 119
Cdd:cd18412    4 PEPVEIIRSKACSRR--------VKINVGGLNHEVLwRTLDRLPRTRLGKLRDcNTHESLLEVCDDYNLNENEYFFDRHP 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 193207406 120 KLTDHVMDFFVTGSLHKPQNVCVERFKEELEYWKIKPDQLSTCCQipSEHHVRK 173
Cdd:cd18412   76 GAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQ--ARYHQKK 127
BTB_POZ_KCNB1 cd18411
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 65-164 5.52e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 1 (KCNB1); KCNB1, also called delayed rectifier potassium channel 1 (DRK1) or voltage-gated potassium channel subunit Kv2.1, mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB1 is involved in the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349718 [Multi-domain]  Cd Length: 117  Bit Score: 62.71  E-value: 5.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  65 MRLNVGGKSYYVR-AELYTSEWTRMHELLD-SSHEERLKMVDGFDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQNVCV 142
Cdd:cd18411   12 VKLNVGGLAHEVLwRTLDRLPRTRLGKLRDcNTHESLMEICDDYNLEENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCA 91

                         90       100
                 ....*....|....*....|..
gi 193207406 143 ERFKEELEYWKIKPDQLSTCCQ 164
Cdd:cd18411   92 LSFSQELDYWGIDEIYLESCCQ 113
BTB_POZ_KCNV2 cd18425
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 65-168 1.28e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 2 (KCNV2); KCNV2, also called voltage-gated potassium channel subunit Kv8.2, is a modulatory voltage-gated potassium channel alpha subunit that modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNV2 is essential for visual function and cone survival. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349732  Cd Length: 108  Bit Score: 61.32  E-value: 1.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  65 MRLNVGGKSY---YVRAELYTSewTRMHELLDS-SHEERLKMVDGFDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQNV 140
Cdd:cd18425    1 LNINVGGTSYqisYRVAASYPK--TRIGRLATYtDRSRKLDLCDDYNVQNDEYFFDRDPAVFHHIYNFYRTGVLWVKDEL 78

                         90       100
                 ....*....|....*....|....*...
gi 193207406 141 CVERFKEELEYWKIKPDQLSTCCQIPSE 168
Cdd:cd18425   79 CPRNFLEEINYWGVRIKNTPRCCRISFE 106
BTB_POZ_KCND2 cd18418
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-163 2.71e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 2 (KCND2); KCND2, also called voltage-gated potassium channel subunit Kv4.2, is a major pore-forming subunit in somatodendritic subthreshold A-type potassium current I(SA) channels. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349725 [Multi-domain]  Cd Length: 103  Bit Score: 60.36  E-value: 2.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  67 LNVGGKsyyvRAELYTSEWTRMHELLDSSHEERLKmvdgFDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQNVCVERFK 146
Cdd:cd18418    4 LNVSGT----RFQTWRNTLERYPDTLLGSSERDFF----YHEETQEYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYD 75

                         90
                 ....*....|....*..
gi 193207406 147 EELEYWKIKPDQLSTCC 163
Cdd:cd18418   76 EELAFFGIIPEIIGDCC 92
BTB_POZ_KCNG4 cd18423
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-163 3.02e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 4 (KCNG4); KCNG4, also called voltage-gated potassium channel subunit Kv6.4, is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG4 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349730 [Multi-domain]  Cd Length: 112  Bit Score: 60.61  E-value: 3.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  67 LNVGGKSYYVR-AELYTSEWTRMHEL-LDSSHEERLKMVDGFDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQNVCVER 144
Cdd:cd18423    6 INVGGIKYLMPwSTLDEFPLTRLGKLkFCSSYEEIVQICDDYDEDTNEFFFDRNPCAFRMIVSFLAAGKLRLLREMCALS 85

                         90
                 ....*....|....*....
gi 193207406 145 FKEELEYWKIKPDQLSTCC 163
Cdd:cd18423   86 FQEELTYWGIEEANLERCC 104
BTB_POZ_Kv5_KCNF1 cd18381
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-164 4.76e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNF/Kv5 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv5, also known as subfamily F, only contains KCNF1 (also known as Kv5.1 or kH1), which functions as a regulatory alpha-subunit of voltage-gated potassium channel that when coassembled with Kv2.1 can modulate gating in a physiologically relevant manner. It forms hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349690  Cd Length: 116  Bit Score: 60.16  E-value: 4.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  67 LNVGGksyyVRAELYTSEW-----TRMHELLD---SSHEERLKMVDGFDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQ 138
Cdd:cd18381    5 VNVGG----VRQVLYGDVLnrypeTRLAELLNclsGGYDAIFSLCDDYDPGKREFYFDRDPDAFKCIIEVYYYGEIHMKK 80

                         90       100
                 ....*....|....*....|....*.
gi 193207406 139 NVCVERFKEELEYWKIKPDQLSTCCQ 164
Cdd:cd18381   81 GICPICFKNEMDFWRVDLDFLDECCK 106
BTB_POZ_KCND3 cd18419
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 38-163 7.55e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.


Pssm-ID: 349726 [Multi-domain]  Cd Length: 138  Bit Score: 59.99  E-value: 7.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  38 VAFRPPPIGESrsttithDSGSNADTYMRLNVGGKsyyvRAELYTSEWTRMHE-LLDSSHEERLkmvdgFDSKTGEYYLE 116
Cdd:cd18419   17 VANCPMPLAPA-------DKNKRQDELIVLNVSGR----RFQTWRTTLERYPDtLLGSTEKEFF-----FNEDTKEYFFD 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 193207406 117 RNAKLTDHVMDFFVTGSLHKPQNVCVERFKEELEYWKIKPDQLSTCC 163
Cdd:cd18419   81 RDPEVFRCVLNFYRTGKLHYPRYECISAYDEELAFYGILPEIIGDCC 127
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 412-491 2.78e-10

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 56.51  E-value: 2.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  412 FLITGIVFFSTIMYYLEkDEPHTDFYSipaGCWWCVVTMATVGYGDAKPVTTLGKLVATSTSICGIIVLAFPISMIVEKF 491
Cdd:pfam07885   1 IVLLLVLIFGTVYYLLE-EGWEWSFLD---ALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFL 76
BTB_POZ_Kv6_KCNG cd18382
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-164 2.40e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv6, also known as subfamily G, includes KCNG1 (Kv6.1), KCNG2 (Kv6.2 or KCNF2), KCNG3 (Kv6.3) and KCNG4 (Kv6.4), which are regulatory alpha subunits and do not form functional channels on their own. KCNG1 can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit, can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNG3, also called voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1, and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. KCNG4 is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.


Pssm-ID: 349691 [Multi-domain]  Cd Length: 109  Bit Score: 54.75  E-value: 2.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  67 LNVGGKSYYV-RAELYTSEWTRMHEL-LDSSHEERLKMVDGFDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQNVCVER 144
Cdd:cd18382    3 INVGGARYSLpWSTLDRFPLTRLSRLkACRSEDDILRVCDDYDVERNEFFFDRSPEAFGVILLFLRAGKLRLLREMCALS 82

                         90       100
                 ....*....|....*....|
gi 193207406 145 FKEELEYWKIKPDQLSTCCQ 164
Cdd:cd18382   83 FQEELAYWGIEEAHLERCCK 102
BTB_KCNC2_4 cd18415
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-170 2.40e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4; KCNC2, also called Shaw-like potassium channel or voltage-gated potassium channel Kv3.2, is a delayed rectifier voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. It contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. KCNC4, also called KSHIIIC or voltage-gated potassium channel subunit Kv3.4, is a novel high-voltage-activating, tetraethylammonium (TEA)-sensitive, type-A potassium channel that mediates the voltage-dependent potassium ion permeability of excitable membranes. It plays a pivotal role in oxidative stress-related neural cell damage as an oxidation-sensitive channel. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC2 and KCNC4 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349722 [Multi-domain]  Cd Length: 124  Bit Score: 55.55  E-value: 2.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  67 LNVGGKSYYV-RAELYTSEWTRMHELLDSSH----EERLKMVDGFDSKTG---EYYLERNAKLTDHVMDFFVTGSLHKPQ 138
Cdd:cd18415    6 LNVGGTRHETyRSTLKTLPGTRLALLASSDPqgdcLTQCSQVGGSDGSPGggnEFFFDRHPGVFAYVLNYYRTGKLHCPA 85

                         90       100       110
                 ....*....|....*....|....*....|..
gi 193207406 139 NVCVERFKEELEYWKIKPDQLSTCCQIPSEHH 170
Cdd:cd18415   86 DVCGPLFEEELAFWGIDETDVEPCCWMTYRQH 117
BTB_POZ_KCNG3 cd18422
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-164 1.28e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 3 (KCNG3); KCNG3, also called voltage-gated potassium channel subunit Kv6.3 or voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG3 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349729  Cd Length: 111  Bit Score: 52.94  E-value: 1.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  67 LNVGGKSYYVRAELYT----SEWTRMHELLdsSHEERLKMVDGFDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQNVCV 142
Cdd:cd18422    3 LNVGGTRYSFSREVIKdfplRRVSRLHGCL--SEQDVLEVCDDYDRERNEYFFDRHSEAFGFIMLYVKYGKLRFVPQMCE 80

                         90       100
                 ....*....|....*....|..
gi 193207406 143 ERFKEELEYWKIKPDQLSTCCQ 164
Cdd:cd18422   81 LSFYNEMIYWGLERSHLEYCCQ 102
BTB_POZ_KCNG1_2 cd18421
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-163 1.53e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G members, KCNG1 and KCNG2; KCNG1, also called voltage-gated potassium channel subunit Kv6.1 or kH2, functions as a regulatory alpha-subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit or voltage-gated potassium channel subunit Kv6.2, is a new gamma-subunit of voltage-gated potassium channels that can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG1 and KCNG2 are regulatory alpha subunits and do not form homomultimers. They form heteromultimers (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349728 [Multi-domain]  Cd Length: 114  Bit Score: 52.83  E-value: 1.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  67 LNVGGKSYYVR-AELYTSEWTRMHEL-LDSSHEERLKMVDGFDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQNVCVER 144
Cdd:cd18421    8 INVGGIKYRIPwTTLEEFPLTRLGQLkSCNNFDEIMDICDDYDVTCNEFFFDRNPCAFRTILTFLRAGKLRLLREMCALS 87

                         90
                 ....*....|....*....
gi 193207406 145 FKEELEYWKIKPDQLSTCC 163
Cdd:cd18421   88 FQEELLYWGIEEENLEWCC 106
PRK10537 PRK10537
voltage-gated potassium channel protein;
401-488 3.63e-07

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 52.33  E-value: 3.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406 401 SSITELSMLSMFLITGIVFFSTIMYYLEKDEPHTDFYSIPAGCWWCVVTMATVGYGDAKPVTTLGKLVATSTSICGIIVL 480
Cdd:PRK10537 131 SSLAAGTLFAVISITSLLFYSTFGALYLGDGFSPPIESLSTAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVF 210


                 ....*...
gi 193207406 481 AFPISMIV 488
Cdd:PRK10537 211 ATSISAIF 218
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 64-165 8.96e-07

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 47.30  E-value: 8.96e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406    64 YMRLNVGGKSYYVRAELYTSEWTRMHELLDSSHEErlkmvdgfDSKTGEYYLERNAKLTDHVMDFFVTGSLHKPQNvCVE 143
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKE--------SDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEE-NVE 71

                           90       100
                   ....*....|....*....|..
gi 193207406   144 RFKEELEYWKIKPDQLSTCCQI 165
Cdd:smart00225  72 ELLELADYLQIPGLVELCEEFL 93
BTB_POZ_KCNA2_KCNA3 cd18403
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 106-154 3.70e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A members 2 (KCNA2) and 3 (KCNA3); KCNA2 is also called NGK1, voltage-gated K(+) channel HuKIV, voltage-gated potassium channel HBK5, or voltage-gated potassium channel subunit Kv1.2. KCNA3 is also called HGK5, HLK3, HPCN3, voltage-gated K(+) channel HuKIII, or voltage-gated potassium channel subunit Kv1.3. KCNA2 and KCNA3 mediate transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA2 primarily functions in the brain and the central nervous system, but also in the cardiovascular system. It prevents aberrant action potential firing and regulates neuronal output. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA2 and KCNA3 are alpha subunits that form functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349711  Cd Length: 99  Bit Score: 36.87  E-value: 3.70e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 193207406 106 FDSKTGEYYLERNAKLTDHVMDFFVTGS-LHKPQNVCVERFKEELEYWKI 154
Cdd:cd18403   37 FDPLRNEYFFDRNRPSFDAILYYYQSGGrLRRPVNVPLDIFSEEIRFYEL 86
BTB_POZ_KCNA10 cd18409
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 98-154 8.22e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 10 (KCNA10); KCNA10, also called voltage-gated potassium channel subunit Kv1.8, is a cyclic nucleotide-gated, voltage-activated potassium channel that mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA10 is expressed in proximal tubular cells, glomerular and vascular endothelial cells, as well as in vascular smooth muscle cells. It may facilitate proximal tubular sodium absorption by stabilizing cell membrane voltage. The channel activity is up-regulated by cAMP. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA10 is an alpha subunit that forms functional homotetrameric channels through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.


Pssm-ID: 349716  Cd Length: 87  Bit Score: 35.59  E-value: 8.22e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 193207406  98 ERLKMVDGFDSKTGEYYLERNAKLTDHVMDFFVT-GSLHKPQNVCVERFKEELEYWKI 154
Cdd:cd18409   29 DPEKRMKYFDSMRNEYFFDRNRPSFDGILYYYQSgGKIRRPANVPLDVFADEIIFYEL 86
BTB_POZ_KCNRG cd18375
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 67-156 9.60e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel regulatory protein (KCNRG); KCNRG, also called potassium channel regulator or protein CLLD4, is an endoplasmic reticulum (ER)-associated tumor suppressor that regulates Kv1 family potassium channel proteins by retaining a fraction of the channels in endomembranes. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.


Pssm-ID: 349684  Cd Length: 97  Bit Score: 35.86  E-value: 9.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193207406  67 LNVGGKSYYVR-AELYTSEWTRMHELLDSSHEErLKMVDGfdsktgEYYLERNAKLTDHVMDFFVTGSLHKPQNVC-VER 144
Cdd:cd18375    5 LNVGGKKFTTRpSTLRRFPDSRLARMLDGKDQD-FKVVNG------QFFVDRDGSLFSYILDYLRTGQLTLPTEFSdYNR 77

                         90
                 ....*....|..
gi 193207406 145 FKEELEYWKIKP 156
Cdd:cd18375   78 LAREAEFYGLYS 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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