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Conserved domains on  [gi|193210844|ref|NP_001123175|]
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Ig-like domain-containing protein [Caenorhabditis elegans]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 12208729)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition

CATH:  2.60.40.10
PubMed:  7932691|10436082

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 280-365 8.38e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.34  E-value: 8.38e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210844   280 QQVNMGCEVEGNPRPIVYWRMrkpngdvvdaacpqglegQYQELPPEGGRsANIVRLTALCSLRISN--YSYSGQYWCAA 357
Cdd:smart00410  10 ESVTLSCEASGSPPPEVTWYK------------------QGGKLLAESGR-FSVSRSGSTSTLTISNvtPEDSGTYTCAA 70


                   ....*...
gi 193210844   358 CSQVSQGE 365
Cdd:smart00410  71 TNSSGSAS 78
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 280-365 8.38e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.34  E-value: 8.38e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210844   280 QQVNMGCEVEGNPRPIVYWRMrkpngdvvdaacpqglegQYQELPPEGGRsANIVRLTALCSLRISN--YSYSGQYWCAA 357
Cdd:smart00410  10 ESVTLSCEASGSPPPEVTWYK------------------QGGKLLAESGR-FSVSRSGSTSTLTISNvtPEDSGTYTCAA 70


                   ....*...
gi 193210844   358 CSQVSQGE 365
Cdd:smart00410  71 TNSSGSAS 78
Ig4_L1-NrCAM_like cd04978
Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), ...
 286-313 5.83e-03

Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related); The members here are composed of the fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related). These proteins belong to the L1 subfamily of cell adhesion molecules (CAMs) and are comprised of an extracellular region having six Ig-like domains and five fibronectin type III domains, a transmembrane region and an intracellular domain. These molecules are primarily expressed in the nervous system. L1 is associated with an X-linked recessive disorder, X-linked hydrocephalus, MASA syndrome, or spastic paraplegia type 1, that involves abnormalities of axonal growth.


Pssm-ID: 409367 [Multi-domain]  Cd Length: 89  Bit Score: 36.27  E-value: 5.83e-03
                         10        20
                 ....*....|....*....|....*...
gi 193210844 286 CEVEGNPRPIVYWRMrkpNGDVVDAACP 313
Cdd:cd04978   21 CEAEGNPQPTITWRL---NGVPIEPAPE 45
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 280-365 8.38e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.34  E-value: 8.38e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 193210844   280 QQVNMGCEVEGNPRPIVYWRMrkpngdvvdaacpqglegQYQELPPEGGRsANIVRLTALCSLRISN--YSYSGQYWCAA 357
Cdd:smart00410  10 ESVTLSCEASGSPPPEVTWYK------------------QGGKLLAESGR-FSVSRSGSTSTLTISNvtPEDSGTYTCAA 70


                   ....*...
gi 193210844   358 CSQVSQGE 365
Cdd:smart00410  71 TNSSGSAS 78
Ig4_L1-NrCAM_like cd04978
Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), ...
 286-313 5.83e-03

Fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related); The members here are composed of the fourth immunoglobulin (Ig)-like domain of L1, Ng-CAM (Neuron-glia CAM cell adhesion molecule), and NrCAM (Ng-CAM-related). These proteins belong to the L1 subfamily of cell adhesion molecules (CAMs) and are comprised of an extracellular region having six Ig-like domains and five fibronectin type III domains, a transmembrane region and an intracellular domain. These molecules are primarily expressed in the nervous system. L1 is associated with an X-linked recessive disorder, X-linked hydrocephalus, MASA syndrome, or spastic paraplegia type 1, that involves abnormalities of axonal growth.


Pssm-ID: 409367 [Multi-domain]  Cd Length: 89  Bit Score: 36.27  E-value: 5.83e-03
                         10        20
                 ....*....|....*....|....*...
gi 193210844 286 CEVEGNPRPIVYWRMrkpNGDVVDAACP 313
Cdd:cd04978   21 CEAEGNPQPTITWRL---NGVPIEPAPE 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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