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Conserved domains on  [gi|194272222|ref|NP_001123562|]
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dynein regulatory complex subunit 3 isoform a [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 42-188 6.93e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 91.00  E-value: 6.93e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272222  42 FKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRI 121
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272222 122 SKIDSLDALVK------------------------------LQVLSLGNNRIDNMMNIIYLRRfkcLRTLSLSRNPISEA 171
Cdd:cd21340   81 SVVEGLENLTNleelhienqrlppgekltfdprslaalsnsLRVLNISGNNIDSLEPLAPLRN---LEQLDASNNQISDL 157

                        170
                 ....*....|....*..
gi 194272222 172 EDykmfICAYLPDLMYL 188
Cdd:cd21340  158 EE----LLDLLSSWPSL 170
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 42-188 6.93e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 91.00  E-value: 6.93e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272222  42 FKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRI 121
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272222 122 SKIDSLDALVK------------------------------LQVLSLGNNRIDNMMNIIYLRRfkcLRTLSLSRNPISEA 171
Cdd:cd21340   81 SVVEGLENLTNleelhienqrlppgekltfdprslaalsnsLRVLNISGNNIDSLEPLAPLRN---LEQLDASNNQISDL 157

                        170
                 ....*....|....*..
gi 194272222 172 EDykmfICAYLPDLMYL 188
Cdd:cd21340  158 EE----LLDLLSSWPSL 170
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
59-296 3.88e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 3.88e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272222  59 DNLWQFENLRKLQLDNNIIEKI-EGLENLAHLVWLDLSFNNIETI-EGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVL 136
Cdd:COG4886  176 EELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEEL 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272222 137 SLGNNRIDNMMNIIYLRRfkcLRTLSLSRNPISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQE 216
Cdd:COG4886  256 DLSNNQLTDLPPLANLTN---LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272222 217 NLMQAQLEDEQAQREELEKHKTAFVEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIICVNIFEYGLKQQE 296
Cdd:COG4886  333 LLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
LRR_9 pfam14580
Leucine-rich repeat;
68-202 7.17e-13

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 66.71  E-value: 7.17e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272222   68 RKLQLDNNIIEKIEGL-ENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKI-DSLD-ALVKLQVLSLGNNRID 144
Cdd:pfam14580  22 RELDLRGYKIPIIENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLGeALPNLTELILTNNNLQ 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 194272222  145 NMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLAE 202
Cdd:pfam14580 102 ELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAE 159
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 42-188 6.93e-21

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 91.00  E-value: 6.93e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272222  42 FKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRI 121
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272222 122 SKIDSLDALVK------------------------------LQVLSLGNNRIDNMMNIIYLRRfkcLRTLSLSRNPISEA 171
Cdd:cd21340   81 SVVEGLENLTNleelhienqrlppgekltfdprslaalsnsLRVLNISGNNIDSLEPLAPLRN---LEQLDASNNQISDL 157

                        170
                 ....*....|....*..
gi 194272222 172 EDykmfICAYLPDLMYL 188
Cdd:cd21340  158 EE----LLDLLSSWPSL 170
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 54-199 2.44e-19

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 86.76  E-value: 2.44e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272222  54 NILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDL------------------S 115
Cdd:cd21340   35 KITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELhienqrlppgekltfdprS 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272222 116 LF------------NNRISKIDSLDALVKLQVLSLGNNRIDNMMNII-YLRRFKCLRTLSLSRNPISEAEDYKMFICAYL 182
Cdd:cd21340  115 LAalsnslrvlnisGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVCKKPKYRDKIILAS 194

                        170
                 ....*....|....*..
gi 194272222 183 PDLMYLDYRRIDDHTKK 199
Cdd:cd21340  195 KSLEVLDGKEITDTERQ 211
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
59-296 3.88e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 3.88e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272222  59 DNLWQFENLRKLQLDNNIIEKI-EGLENLAHLVWLDLSFNNIETI-EGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVL 136
Cdd:COG4886  176 EELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEEL 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272222 137 SLGNNRIDNMMNIIYLRRfkcLRTLSLSRNPISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLAEAKHQYSIDELKHQE 216
Cdd:COG4886  256 DLSNNQLTDLPPLANLTN---LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272222 217 NLMQAQLEDEQAQREELEKHKTAFVEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIICVNIFEYGLKQQE 296
Cdd:COG4886  333 LLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-170 6.12e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.81  E-value: 6.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272222  49 QLDFRNILRIDNLWQFENLRKLQLDNNIIEKI-EGLENLAHLVWLDLSFNNIETI-EGLDTLVNLEDLSLFNNRISKI-D 125
Cdd:COG4886   97 NLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpE 176

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 194272222 126 SLDALVKLQVLSLGNNRIDNMMNIIYlrRFKCLRTLSLSRNPISE 170
Cdd:COG4886  177 ELGNLTNLKELDLSNNQITDLPEPLG--NLTNLEELDLSGNQLTD 219
LRR_9 pfam14580
Leucine-rich repeat;
68-202 7.17e-13

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 66.71  E-value: 7.17e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272222   68 RKLQLDNNIIEKIEGL-ENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKI-DSLD-ALVKLQVLSLGNNRID 144
Cdd:pfam14580  22 RELDLRGYKIPIIENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLGeALPNLTELILTNNNLQ 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 194272222  145 NMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPDLMYLDYRRIDDHTKKLAE 202
Cdd:pfam14580 102 ELGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAAE 159
LRR_8 pfam13855
Leucine rich repeat;
66-121 2.55e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 2.55e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272222   66 NLRKLQLDNNIIEKIEG--LENLAHLVWLDLSFNNIETIEG--LDTLVNLEDLSLFNNRI 121
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
88-143 1.19e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 1.19e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272222   88 HLVWLDLSFNNIETIEG--LDTLVNLEDLSLFNNRISKI--DSLDALVKLQVLSLGNNRI 143
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLspGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-152 8.60e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 8.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272222  47 SLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIET--IEGLDTLVNLEDLSLFNNRISKI 124
Cdd:COG4886  232 TLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDlkLKELELLLGLNSLLLLLLLLNLL 311

                         90       100
                 ....*....|....*....|....*...
gi 194272222 125 DSLDALVKLQVLSLGNNRIDNMMNIIYL 152
Cdd:COG4886  312 ELLILLLLLTTLLLLLLLLKGLLVTLTT 339
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 110-145 1.23e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.54  E-value: 1.23e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 194272222  110 NLEDLSLFNNRISKIDSLDALVKLQVLSL-GNNRIDN 145
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLsGNNKITD 38
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 88-128 1.69e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 1.69e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 194272222   88 HLVWLDLSFNNIETIEGLDTLVNLEDLSL-FNNRISKIDSLD 128
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLsGNNKITDLSDLA 43
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 66-106 5.44e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.61  E-value: 5.44e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 194272222   66 NLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNN-IETIEGLD 106
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLA 43
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-170 8.67e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.84  E-value: 8.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272222  40 ILFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDTLVNLEDLSLFNN 119
Cdd:COG4886   27 LLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN 106

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 194272222 120 riskiDSLDALVKLQVLSLGNNRIDNMmnIIYLRRFKCLRTLSLSRNPISE 170
Cdd:COG4886  107 -----EELSNLTNLESLDLSGNQLTDL--PEELANLTNLKELDLSNNQLTD 150
LRR_8 pfam13855
Leucine rich repeat;
110-168 3.83e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 3.83e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194272222  110 NLEDLSLFNNRISKID--SLDALVKLQVLSLGNNRIdnmmNIIY---LRRFKCLRTLSLSRNPI 168
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLL----TTLSpgaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
47-99 3.83e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 3.83e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 194272222   47 SLQLDFRNILRIDNLW--QFENLRKLQLDNNIIEKIEG--LENLAHLVWLDLSFNNI 99
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAfkGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 67-177 5.05e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 5.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272222  67 LRKLQLDNN------IIEKIEGLENLAHLVWLDLSFNNIETI------EGLDTLVNLEDLSLFNNRISKID-------SL 127
Cdd:cd00116  167 LKELNLANNgigdagIRALAEGLKANCNLEVLDLNNNGLTDEgasalaETLASLKSLEVLNLGDNNLTDAGaaalasaLL 246

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 194272222 128 DALVKLQVLSLGNNRI---DNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMF 177
Cdd:cd00116  247 SPNISLLTLSLSCNDItddGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLA 299
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 66-170 6.57e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.00  E-value: 6.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272222  66 NLRKLQLDNNIIEK------IEGLENLAHLVWLDLSFNNI------ETIEGLDTLVNLEDLSLFNNRISK------IDSL 127
Cdd:COG5238  265 TVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIgdegaiALAEGLQGNKTLHTLNLAYNGIGAqgaialAKAL 344

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 194272222 128 DALVKLQVLSLGNNRIDN--MMNII-YLRRFKCLRTLSLSRNPISE 170
Cdd:COG5238  345 QENTTLHSLDLSDNQIGDegAIALAkYLEGNTTLRELNLGKNNIGK 390
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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