NCBI Conserved Domain Search

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 361.16 E-value: 9.84e-115

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  870 NSISLNFTNLVDVTQSLGFYLGNVQPYCEHDWTLCFTGDSKQASSPRYVETQSMQIGASYMIQFSLVMGCGERYTPHMDN 949
Cdd:cd10038     1 NSISLDFSNLVEVTQSLGFYLGNVQPYCNHDWTLCFTGDSKHASSARYVETQSMQIGASYMIQFSLVMGCGQQYTPHMDN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  950 QVMLEYSTNHGLTWHLVQQECLPSMPSCQEFTSSSIYHSSEFTHWRRITLPLPQKTWSGATRFRWSQRYYTSDDEWALDN 1029
Cdd:cd10038    81 QVKLEYSTNHGLTWHLVQEECLPGMPSCQEFTSGSIYHSSEFTEWRRITLPLPQKTWSSATRFRWSQSYYTDQDEWALDN 160


                  ....*...
gi 212549597 1030 IYIGQQCP 1037
Cdd:cd10038   161 IYIGQQCP 168

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 354.22 E-value: 2.42e-112

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1609 GFQDKFDGSVDLHANWYRIQGGQVDVDCLSMDTALLFNENIGKPRYAETWDFHVMPSSSLQFNLNMGCSKQLSNSHVVQL 1688
Cdd:cd10040     1 GFQDKFDGSVDLQANWYRIQGGQVDIDCLSMDTALMFTENIGKPRYAETWDFHVSASTFLQFELSMGCSKPYSNSHSVQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1689 QFSVNNGRDWQQVTEECIPPSIGCLHYTESSVYSSERFQTSKRITVYLPSATVSPRTRFRWIQYNYGSGADAWAIDNVVL 1768
Cdd:cd10040    81 QYSLNNGRDWHLVTEECVPPAIGCLHYTESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYAPGADSWAIDNVVL 160

                         170
                  ....*....|
gi 212549597 1769 SSGCPWMCSG 1778
Cdd:cd10040   161 ASGCPWMCSG 170

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 341.80 E-value: 6.43e-108

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1243 YEKPAFDYPVNQMNVWLMLANEGMPKNESfCSLTPSAMIFGKSDGDRFAVTRDLTLKPGYVLQFKLNVGCTNEFSGMAPV 1322
Cdd:cd10039     1 YEKPAFDYPLNQMSVWLMLSNEGMGKNES-CSPTPSAMVFGKSDGDRFAVTRDLTLKPGYVLQFKVNIGCTSEFSSFAPV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1323 LLQYSHDAGLSWSLVREGCYPASPGIKDCEGSSRELGEPTSYYTGDYEDWTRITIVIPRSLASSKTRFRWIQESSSFSNV 1402
Cdd:cd10039    80 LLQYSHDAGLTWSLVREGCYPASPGSKGCEGSSRELREPTVYHTGDYEDWTRITIPIPRSLAASKTRFRWIQESSSLKNA 159

                         170
                  ....*....|.
gi 212549597 1403 PAFGLDGVYIS 1413
Cdd:cd10039   160 PPFGLDGVYIS 170

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 338.31 E-value: 6.31e-107

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3269 PSYIKDNFESEKVTEINWENIQGGVIGNGCGQLSPYAHGDSLYFNGCQIRQAITKPLDLTRASKIMFVLQIGSIAQTDSC 3348
Cdd:cd10052     1 PSYIKDNFESGSVSELKWSLIQGGGIGSGCGQLAPHAHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSRSQTDSC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3349 NTNLSDTNTVDKAVLLQYSVNNGITWQVIAQHQPKDFIQAQRVSYNIPLEARMKGVLLRWWQPRHNGIGHDQWALDHVEV 3428
Cdd:cd10052    81 NINLSSPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDNVEV 160


                  .
gi 212549597 3429 V 3429
Cdd:cd10052   161 V 161

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 332.14 E-value: 1.68e-104

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1960 ILLDTFDFGPNEENWFFYPGGNIALYCPYTSKGSPEEDSAMVFVSNEVGEHSITTRDLDVDENTIIQFEINVGCTSDSSS 2039
Cdd:cd10041     1 LLLDTFDFGPNESNWLFYPGGNTGLYCPYQSKGAPEEDSAMVFVSSELGEHSITTRDLDVNENTIIQFEINVGCTTESSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2040 ADPVKLEFSRDFGATWHLLLPLCYsSSSHISSLCSTEHHPSSTYYAGTTQGWRREVINFGKLRLCGSIRFRWYQGFYPIT 2119
Cdd:cd10041    81 ADPVRLEFSRDFGATWHLLLPLCY-GSSSISSLCSTELHPSSVYYTGTTQGWRREVILFGKLHLCGSVRFRWYQGFHPAG 159

                         170
                  ....*....|....*
gi 212549597 2120 MQPVTWAIDNIYIGP 2134
Cdd:cd10041   160 SQPVTWAIDNVYIGP 174

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 329.59 E-value: 1.07e-103

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2673 VMLDTFSSAPLPQHERTPadsgptgrisfemfsEDKTTVNKHWLFHDDCSIERFCDSPDGVMICGSH-DGREVYTVTHDL 2751
Cdd:cd10043     1 VLLDTFSSANLPQHERSP---------------EDKTTVNDHWLFHDNCSIERFCDSPDGVMICGSHdDGREVSAVTHDL 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2752 TPAEGWIMQFKIAVGCRSSEKNVQNQVHVQYSTDFGVSWTYLVPQCLPADPKCSGTVSQPSVFFPAKGWKRVTYTLPDSL 2831
Cdd:cd10043    66 TPTEGWILQFKISVGCKSSEKSAQQPVHVQYSTDFGVSWSYVTPQCLPSDPKCGGSVTQPSVFFPSKGWRRVTIPLPDKL 145

                         170       180
                  ....*....|....*....|....*.
gi 212549597 2832 IGNPVRFRFYQKYSDMQWAIDNFYIG 2857
Cdd:cd10043   146 VGRPIRFRFYQKASDMQWALDNFYIG 171

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 327.57 E-value: 7.16e-103

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3058 PSQLVDTFDDEGTSHDEHWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKTHNILSSRELIIQPGYMIQFKIVVGCD-VSSC 3136
Cdd:cd10044     1 PSSLVETFEDEGTSHDENWEFYPNGVRTDEFCGNPSFHLTWPNKKKDKTHNALTTRQLIVQPGYMIQFKIVVGCGsVSSC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3137 VDLHSVMLEYTKDARTDSWQLVQTQCLPSSSNSVGCSPFLFHEASIYNSVNSSVWKRVTLQLPDYVSSSATQFRWIQKGD 3216
Cdd:cd10044    81 GDLHPVMLEYTTDPRSDHWQLVQTECLPSSSNSIDCSPFQYHEASIYSSVNSSVWKRVTIQLPDHVSSSATQFRWIQKTE 160

                         170
                  ....*....|....*.
gi 212549597 3217 ETEKQSWAVDHVYIGE 3232
Cdd:cd10044   161 STEAPSWAIDDVYIGE 176

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 326.48 E-value: 9.39e-103

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2326 VIEDDFSSLDNKKWLLHPGGTKMSVCGSSGDALVFIEKASTRYVVTTDIVVNEDSFLQIDFAASCSVTDSCYAIELEYSV 2405
Cdd:cd10042     1 VLEDDFSTLDSRKWLLHPGGTKMPVCGSTGDALVFIEKASTRYVVTTDIMVNEDSFLQIDFAASCSVTDSCYAIELEYSV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 212549597 2406 DLGLSWNPVLKDCLPTNVECSNYQLQRALVSDTFNKWTRFTLPLPPYTRSQATRFRWNQPSPFDKQQTWAIDNVYIG 2482
Cdd:cd10042    81 DLGLSWHPLLRDCLPTNVECSSYHLQRILVSDTFNKWTRVTLPLPHYTRSQATRFRWHQPAPFDKQQTWAIDNVYIG 157

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 320.64 E-value: 8.93e-101

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1068 LPSTIMSDFEGLNGWETDWLEVVGGEIVKPEQGCGIISSGSSMYFYKDGRRQLVSLDMDTTWVDFIQFYIQIGGETTSCN 1147
Cdd:cd10046     1 LPSTVMSDFENQDSLETEWQEVIGGEIVKPEMGCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGGSASCN 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 212549597 1148 KPDSREEGVLLQYSNNGGINWHLLAEMYFSDFIKSKFVYLELPNAARTPCTRFRWWQPVFSGEGYDQWAIDDVIIL 1223
Cdd:cd10046    81 YPDSREEGVLLQYSNNGGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALDDIIIL 156

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 320.19 E-value: 1.49e-100

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2893 KTFLKERFDSEEIRSDFWLSVDGGKTCTDCGVLAEDMALYFGASAVRQTITQDLDLRGAKFVQYWARIGSE-NMTSCRKP 2971
Cdd:cd10051     1 KTFLKERFDSEEISSDQWLSLEGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSEnNMTLCLRP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2972 VCRKEGVLLDYSIDGGITWTLLHEMDYQKYMSVRYDYILLPENAQTNTTRLRWWQPFTVSNGLVVLGQERSQWALDNILI 3051
Cdd:cd10051    81 TCRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPFTISNGLVVSGTERAQWALDNILI 160


                  ..
gi 212549597 3052 GG 3053
Cdd:cd10051   161 GG 162

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 316.44 E-value: 2.40e-99

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1804 LPSILKDDFNGNLHPDLWPEVYGGERGNLNGETIKSGTALIFKGDGLRMLISRDLDCTHTLYIQFSFKFITKGTPERSHS 1883
Cdd:cd10048     1 LPSVLKDDFNGNLRPDLWPEVYGAERGNLNGETIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKFITKGTPERSHS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1884 ILLQYSISGGITWHLMDEFYFTQTTDVLFVNVPLPNTAQTNATRFRLWQPYHNGKKDEVWIIEDFVIDGN 1953
Cdd:cd10048    81 VLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDLVIDGN 150

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 315.59 E-value: 5.78e-99

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  711 PVFISESFTSSRLSSYHNFYSIRGAEVSFGCGVLASGKALIFNKDGRRQLITAFLDSSQSRFLQFTLRIGSKSVLSTCKA 790
Cdd:cd10045     1 PGFLSESFNSSRLSSYHNFSSIRGGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVLGTCPP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 212549597  791 PDKPGEGVLLHYSHDNGITWKLMEHYSYLSYHEPRIISVELPEDAKQFGIQFRWWQPYHSGQGEDVWAIDEIIMT 865
Cdd:cd10045    81 PDRPGEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEISMT 155

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 314.10 E-value: 1.25e-98

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  529 VISPDLQTPATKFCLKQNNHRGHNLNVWAVDFVHVLPVLPSTESHMVQFSINLGCGSHQPGNSVRLEFSTNHGRSWSLLH 608
Cdd:cd10037     1 PIPPDLQTPATKFCLRQKSHGGHNRNVWAVDFFHLLPVLPSTVTHFAQFSINLGCGSHQPGNSVSLEFSTNHGRSWSLLH 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 212549597  609 SECLPELCAGSHLPHSTIYSSDNYSGWNRITIPLPNAALTRDTRLRWRQNGPVMGNMWALDNIYIG 674
Cdd:cd10037    81 TECLPELCAGPHLPHSTVYSSDNYSGWNRITIPLPNAALTSATRFRWRQTGSVVGSMWAIDNVYIG 146

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 314.08 E-value: 1.29e-98

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2518 LPTQLKDTFNRAPSSHNWLTVNGGKLSSVCGAVASGMALHFSGGCSRLLVSVDLNLTNAEFVQFYFMYGCLIIPHSRNQG 2597
Cdd:cd10050     1 LPTQLKDTFNRAPSSSNWLTVVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGCLIPPSNRNQG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 212549597 2598 VLLEYSVNGGINWFLLMEIFYDQYSKPGFVNILLPASAKTVGTRFRWWQPKHDGLDQNDWAIDNVLIS 2665
Cdd:cd10050    81 VLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAIDNVLIG 148

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 312.60 E-value: 4.77e-98

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2169 NPDFLKDDFEGQLESDRFLLVSGGKTSRKCGILSSGNNLFFNEEGLRMLVTRDLDLSLARFVQFFMRLGCGKAVPDPRSQ 2248
Cdd:cd10049     1 NPDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLGCGKGVPDPRSQ 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2249 PVLLQFSLDGGLSWSVLQEFHFSNSSNVGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILIG 2318
Cdd:cd10049    81 PVLLQYSLNGGLTWSLLQEFLFSNSSNVGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILIG 150

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 311.37 E-value: 1.19e-97

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1451 PSEMFDRFEGKLSQQWYKITGGQVGTGCGVLSDGKSLYLNGPGKREARTAALDTTNTRLIQFYIQIGNTNGGSTCGKPKA 1530
Cdd:cd10047     1 PSEFFDRFEGKLSPLWYKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNGETCLRPRS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 212549597 1531 RNEGVVVQYTNDNGISWNLLRELDFMSYLEPQIISIELPRNAKTSGTAFRWWQPQHGKQSAQWALDDVLIG 1601
Cdd:cd10047    81 RNEGIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQHGKPSAQWALDDVLIG 151

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 273.58 E-value: 1.92e-84

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  205 LRDDFDSYKLQELNPNIWLQCRNCEVGEQCGVIMHSGAVTFCDPYGPRELISVQMNTTTASVLQFSIGSGSCRFSYSDPG 284
Cdd:cd10036     1 LRDDFDSYPLLELNNNIWSECCGCNVGEQCGVIMHGNALTFCEPYGPRELITVPLNTTTASVLQFAIGSGSCRFSYSDPS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 212549597  285 IVVSYTKNNSSS-WVPLERISAPSNVSTIIHIIYLPPEVKGDSVKFRWRQENMQAGDVYEACWALDNILII 354
Cdd:cd10036    81 IIVSYAVNNTSSdWITLEKIRAPSNGSTIIHIIPLPTDAKQDNVSFRFRQEAPNAGEVYESCWALDNVLII 151

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 255.61 E-value: 3.57e-78

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1072 IMSDFEGLNGWETDWLEVVGGEIVkpeQGCGIISSGSSMYFYKDGRRQLVSLDMDTTWVDFIQFYIQIGGE--TTSCNKP 1149
Cdd:cd08526     2 LKDSFEGSLSSSDNWSLVSGGEVG---TGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKsqTSTCNPP 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 212549597 1150 DSREEGVLLQYSNNGGINWHLLAEMYFSDFIKSKFVYLELPNAARTPCTRFRWWQPVFSGEGYDQWAIDDVII 1222
Cdd:cd08526    79 DSRSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALDNILI 151

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 249.45 E-value: 5.39e-76

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1453 EMFDRFEGKLS--QQWYKITGGQVGTGCGVLSDGKSLYLNGPGKREARTAALDTTNTRLIQFYIQIGNTNGGSTCGKPKA 1530
Cdd:cd08526     1 FLKDSFEGSLSssDNWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSQTSTCNPPDS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 212549597 1531 RNEGVVVQYTNDNGISWNLLRELDFMSYLEPQIISIELPRNAKTSGTAFRWWQPQH-GKQSAQWALDDVLIG 1601
Cdd:cd08526    81 RSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHsGKGQDQWALDNILIG 152

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 246.37 E-value: 6.88e-75

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  713 FISESFTSSRLSSyHNFYSIRGAEVSFGCGVLASGKALIFNKDGRRQLITAFLDSSQSRFLQFTLRIGSKSVLSTCKAPD 792
Cdd:cd08526     1 FLKDSFEGSLSSS-DNWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSQTSTCNPPD 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 212549597  793 KPGEGVLLHYSHDNGITWKLMEHYSYLSYHEPRIISVELPEDAKQFGIQFRWWQPYHSGQGEDVWAIDEIIMT 865
Cdd:cd08526    80 SRSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALDNILIG 152

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 244.44 E-value: 3.33e-74

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2895 FLKERFDSEEIRSDFWLSVDGGKTCTDCGVLAEDMALYFGASAVRQTITQDLDLRGAKFVQYWARIGSENMTS-CRKPVC 2973
Cdd:cd08526     1 FLKDSFEGSLSSSDNWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSQTStCNPPDS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212549597 2974 RKEGVLLDYSIDGGITWTLLHEMDYQKYMSVRYDYILLPENAQTNTTRLRWWQPFTVsnglvvlGQERSQWALDNILIG 3052
Cdd:cd08526    81 RSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHS-------GKGQDQWALDNILIG 152

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 242.90 E-value: 1.26e-73

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2521 QLKDTFNRAPSS-HNWLTVNGGKLSSVCGAVASGMALHFSGGCSRLLVSVDLNLTNAEFVQFYFMYGCLII------PHS 2593
Cdd:cd08526     1 FLKDSFEGSLSSsDNWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSQtstcnpPDS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 212549597 2594 RNQGVLLEYSVNGGINWFLLMEIFYDQYSKPGFVNILLPASAKTVGTRFRWWQPKHDGLDQNDWAIDNVLI 2664
Cdd:cd08526    81 RSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALDNILI 151

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 237.27 E-value: 1.23e-71

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1609 GFQDKFDGSVDLHANWYRIQGGQVDVDCLSMDTALLFNENIGKPRYAETWDFHVMPSSSLQFNLNMGCSKQLSNSHVVQL 1688
Cdd:cd08525     1 VLLDTFDTLPDSNENWFFYPGGVVKNDCGSTDSALVFTENIGGERYAVTRDLTVNEGYMLQFKINVGCSSTFSSSNSVML 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1689 QFSVNNGRDWQQVTEECIPPSIGCLHYTESSVYSSERFQTSKRITVYLPSATVSPRTRFRWIQYNYGSGADAWAIDNVVL 1768
Cdd:cd08525    81 EYSTDAGLSWHLVQEECLPSSPGCSELHPSSVYESSTFNGWKRITIPLPNATLSSATRFRWIQYGYTSGVQTWAIDNVYI 160


                  .
gi 212549597 1769 S 1769
Cdd:cd08525   161 G 161

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 229.42 E-value: 5.97e-69

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3271 YIKDNFESEKVTEINWENIQGGVIGNGCGQLspyAHGDSLYFNGCQIRQAITKPLDLTRASKIMFVLQIGSIAQTDSCNT 3350
Cdd:cd08526     1 FLKDSFEGSLSSSDNWSLVSGGEVGTGCGVL---ASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSQTSTCNP 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212549597 3351 nlsdTNTVDKAVLLQYSVNNGITWQVIAQHQPKDFIQAQRVSYNIPLEARMKGVLLRWWQPRHNGIGHDQWALDHVEVV 3429
Cdd:cd08526    78 ----PDSRSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALDNILIG 152

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 229.04 E-value: 8.71e-69

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2172 FLKDDFEGQLES-DRFLLVSGGKTSRKCGILSSGNNLFFNEEGLRMLVTRDLDLSLARFVQFFMRLGCGKA-----VPDP 2245
Cdd:cd08526     1 FLKDSFEGSLSSsDNWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKSQtstcnPPDS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 212549597 2246 RSQPVLLQFSLDGGLSWSVLQEFHFSNSSNVgRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILIG 2318
Cdd:cd08526    81 RSEGVLLQYSVNGGITWHLLQELYYDQYSEP-RFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALDNILIG 152

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 226.48 E-value: 7.87e-68

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  871 SISLNFTNLVDVTQSLGFYLGNVQPY--CEHDWTLCFTGDSKqasSPRYVETQSMQIGASYMIQFSLVMGCGerYTPHMD 948
Cdd:cd08525     1 VLLDTFDTLPDSNENWFFYPGGVVKNdcGSTDSALVFTENIG---GERYAVTRDLTVNEGYMLQFKINVGCS--STFSSS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  949 NQVMLEYSTNHGLTWHLVQQECLPSMPSCQEFTSSSIYHSSEFTHWRRITLPLPQKTWSGATRFRWSQRYYTS-DDEWAL 1027
Cdd:cd08525    76 NSVMLEYSTDAGLSWHLVQEECLPSSPGCSELHPSSVYESSTFNGWKRITIPLPNATLSSATRFRWIQYGYTSgVQTWAI 155


                  ....*.
gi 212549597 1028 DNIYIG 1033
Cdd:cd08525   156 DNVYIG 161

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 220.70 E-value: 8.21e-66

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2326 VIEDDFSSLDN--KKWLLHPGGTKMSVCGSSGDALVFIEK-ASTRYVVTTDIVVNEDSFLQIDFAASC-SVTDSCYAIEL 2401
Cdd:cd08525     1 VLLDTFDTLPDsnENWFFYPGGVVKNDCGSTDSALVFTENiGGERYAVTRDLTVNEGYMLQFKINVGCsSTFSSSNSVML 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2402 EYSVDLGLSWNPVLKDCLPTNVECSNYQLQRALVSDTFNKWTRFTLPLPPYTRSQATRFRWNQPSPFDKQQTWAIDNVYI 2481
Cdd:cd08525    81 EYSTDAGLSWHLVQEECLPSSPGCSELHPSSVYESSTFNGWKRITIPLPNATLSSATRFRWIQYGYTSGVQTWAIDNVYI 160


                  .
gi 212549597 2482 G 2482
Cdd:cd08525   161 G 161

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 216.32 E-value: 1.91e-64

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1808 LKDDFNGNLHP-DLWPEVYGGERGNLNGEtIKSGTALIFKGDGLRMLISRDLDCTHTLYIQFSFKFITK-------GTPE 1879
Cdd:cd08526     2 LKDSFEGSLSSsDNWSLVSGGEVGTGCGV-LASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKsqtstcnPPDS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 212549597 1880 RSHSILLQYSISGGITWHLMDEFYFTQTTDVLFVNVPLPNTAQTNATRFRLWQPYHNGKKDEVWIIEDFVID 1951
Cdd:cd08526    81 RSEGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALDNILIG 152

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 215.70 E-value: 4.39e-64

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1960 ILLDTFDFGPNE-ENWFFYPGGNIALYCPytskgspEEDSAMVFVSNEVGEHSITTRDLDVDENTIIQFEINVGCTSDSS 2038
Cdd:cd08525     1 VLLDTFDTLPDSnENWFFYPGGVVKNDCG-------STDSALVFTENIGGERYAVTRDLTVNEGYMLQFKINVGCSSTFS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2039 SADPVKLEFSRDFGATWHLLLPLCYSSSSHISslcstEHHPSSTYYAGTTQGWRREVINFGKLRLCGSIRFRWYQGFYPi 2118
Cdd:cd08525    74 SSNSVMLEYSTDAGLSWHLVQEECLPSSPGCS-----ELHPSSVYESSTFNGWKRITIPLPNATLSSATRFRWIQYGYT- 147

                         170
                  ....*....|....*
gi 212549597 2119 tMQPVTWAIDNIYIG 2133
Cdd:cd08525   148 -SGVQTWAIDNVYIG 161

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 214.16 E-value: 1.59e-63

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1243 YEKPAFDYPVNQmNVWLMLANEGMPKNesFCSLTPSAMIF-GKSDGDRFAVTRDLTLKPGYVLQFKLNVGCTNEFSGMAP 1321
Cdd:cd08525     1 VLLDTFDTLPDS-NENWFFYPGGVVKN--DCGSTDSALVFtENIGGERYAVTRDLTVNEGYMLQFKINVGCSSTFSSSNS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1322 VLLQYSHDAGLSWSLVREGCYPASPGIKdcegssrELGEPTSYYTGDYEDWTRITIVIPRSLASSKTRFRWIQEsSSFSN 1401
Cdd:cd08525    78 VMLEYSTDAGLSWHLVQEECLPSSPGCS-------ELHPSSVYESSTFNGWKRITIPLPNATLSSATRFRWIQY-GYTSG 149

                         170
                  ....*....|..
gi 212549597 1402 VPAFGLDGVYIS 1413
Cdd:cd08525   150 VQTWAIDNVYIG 161

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 211.52 E-value: 7.20e-63

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2522 LKDTFNRAPSSHNWLTVNGGKLSSVCGAVASGMALHFSGG-CSRLLVSVDLNLTNAEFVQFYFMYGCLIiPHSRNQGVLL 2600
Cdd:cd08524     1 LKDDFDGYPSPDNWLLCPGGKTGTVCGALSSGNALVFNEPyGPRELVTTDLNTNEASFLQFYIGSGCST-PSYSNQPVLL 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 212549597 2601 EYSVNGGINWFLLMEIFYDQYSKPGFVNILLPASAKTVGTRFRWWQPKHDGLDQNDWAIDNVLIS 2665
Cdd:cd08524    80 EYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNVLIG 144

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 209.21 E-value: 5.34e-62

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2173 LKDDFEGQLESDRFLLVSGGKTSRKCGILSSGNNLFFNE-EGLRMLVTRDLDLSLARFVQFFMRLGCGKavPDPRSQPVL 2251
Cdd:cd08524     1 LKDDFDGYPSPDNWLLCPGGKTGTVCGALSSGNALVFNEpYGPRELVTTDLNTNEASFLQFYIGSGCST--PSYSNQPVL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 212549597 2252 LQFSLDGGLSWSVLQEFHFSnSSNVGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILIG 2318
Cdd:cd08524    79 LEYSVDNGASWHLLEEIRAD-SFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNVLIG 144

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 209.15 E-value: 1.09e-61

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3060 QLVDTFDDEGTSHdEHWSFYPNAVRTAgFCGNPSFHLYWPNKKKDktHNILSSRELIIQPGYMIQFKIVVGCDvSSCVDL 3139
Cdd:cd08525     1 VLLDTFDTLPDSN-ENWFFYPGGVVKN-DCGSTDSALVFTENIGG--ERYAVTRDLTVNEGYMLQFKINVGCS-STFSSS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3140 HSVMLEYTKDArTDSWQLVQTQCLPSSSNSVGCSPFLFHEASIYNsvnssVWKRVTLQLPDYVSSSATQFRWIQKGDETE 3219
Cdd:cd08525    76 NSVMLEYSTDA-GLSWHLVQEECLPSSPGCSELHPSSVYESSTFN-----GWKRITIPLPNATLSSATRFRWIQYGYTSG 149

                         170
                  ....*....|..
gi 212549597 3220 KQSWAVDHVYIG 3231
Cdd:cd08525   150 VQTWAIDNVYIG 161

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 193.41 E-value: 1.57e-56

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1454 MFDRFEGKLSQQ-WYKITGGQVGTGCGVLSDGKSLYLNGP-GKREARTAALDTTNTRLIQFYIQIGntnggstCGKPKAR 1531
Cdd:cd08524     1 LKDDFDGYPSPDnWLLCPGGKTGTVCGALSSGNALVFNEPyGPRELVTTDLNTNEASFLQFYIGSG-------CSTPSYS 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 212549597 1532 NEGVVVQYTNDNGISWNLLRELDFMSYLEPQIISIELPRNAKTSGTAFRWWQPQHGK-QSAQWALDDVLIG 1601
Cdd:cd08524    74 NQPVLLEYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGvYQATWAIDNVLIG 144

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 191.81 E-value: 1.15e-55

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  529 VISPDLQTP----ATKFCLKQNNHR-----GHNLNVWAV---DFVHVLPVLPST-ESHMVQFSINLGCGS-HQPGNSVRL 594
Cdd:cd08525     1 VLLDTFDTLpdsnENWFFYPGGVVKndcgsTDSALVFTEnigGERYAVTRDLTVnEGYMLQFKINVGCSStFSSSNSVML 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  595 EFSTNHGRSWSLLHSECLPELCAGSHLPHSTIYSSDNYSGWNRITIPLPNAALTRDTRLRWRQNGPVMG-NMWALDNIYI 673
Cdd:cd08525    81 EYSTDAGLSWHLVQEECLPSSPGCSELHPSSVYESSTFNGWKRITIPLPNATLSSATRFRWIQYGYTSGvQTWAIDNVYI 160


                  .
gi 212549597  674 G 674
Cdd:cd08525   161 G 161

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 187.64 E-value: 2.00e-54

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1961 LLDTFDFGPNEENWFFYPGGNIALYCpytskGSPEEDSAMVFVSNEvGEHSITTRDLDVDENTIIQFEINVGCTSDSSSA 2040
Cdd:cd08524     1 LKDDFDGYPSPDNWLLCPGGKTGTVC-----GALSSGNALVFNEPY-GPRELVTTDLNTNEASFLQFYIGSGCSTPSYSN 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2041 DPVKLEFSRDFGATWHLLLplcysssshisslcstehhpssTYYAGTTQGWRREVINFGKLRLCGSIRFRWYQGFYPiTM 2120
Cdd:cd08524    75 QPVLLEYSVDNGASWHLLE----------------------EIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHR-GV 131

                         170
                  ....*....|...
gi 212549597 2121 QPVTWAIDNIYIG 2133
Cdd:cd08524   132 YQATWAIDNVLIG 144

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 184.94 E-value: 1.39e-53

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2327 IEDDFSSLD-NKKWLLHPGGTKMSVCG--SSGDALVFIEKASTRYVVTTDIVVNEDSFLQIDFAASCS-VTDSCYAIELE 2402
Cdd:cd08524     1 LKDDFDGYPsPDNWLLCPGGKTGTVCGalSSGNALVFNEPYGPRELVTTDLNTNEASFLQFYIGSGCStPSYSNQPVLLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2403 YSVDLGLSWNPVLKdclptnvecsnyqlqraLVSDTFNKWTRFTLPLPPYTRSQATRFRWNQPSPFD-KQQTWAIDNVYI 2481
Cdd:cd08524    81 YSVDNGASWHLLEE-----------------IRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGvYQATWAIDNVLI 143


                  .
gi 212549597 2482 G 2482
Cdd:cd08524   144 G 144

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 184.94 E-value: 1.43e-53

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  205 LRDDFDSYklqeLNPNIWLQCRNCEVGEQCGVIMHSGAVTFCDPYGPRELISVQMNTTTASVLQFSIGSGSCRFSYSDPG 284
Cdd:cd08524     1 LKDDFDGY----PSPDNWLLCPGGKTGTVCGALSSGNALVFNEPYGPRELVTTDLNTNEASFLQFYIGSGCSTPSYSNQP 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  285 IVVSYTKNNSSSWVPLERISAPSNVSTIIHIIYLPPEVKGDSVKFRWRQENMqaGDVYEACWALDNILII 354
Cdd:cd08524    77 VLLEYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNH--RGVYQATWAIDNVLIG 144

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 175.64 E-value: 5.17e-50

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2710 TVNKHWLFHDDCSIERFC-DSPDGVMICGSHDGrEVYTVTHDLTPAEGWIMQFKIAVGCrSSEKNVQNQVHVQYSTDFGV 2788
Cdd:cd08525    11 DSNENWFFYPGGVVKNDCgSTDSALVFTENIGG-ERYAVTRDLTVNEGYMLQFKINVGC-SSTFSSSNSVMLEYSTDAGL 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 212549597 2789 SWTYLVPQCLPADPKCSG----TVSQPSVFFpakGWKRVTYTLPDSLIGNPVRFRFYQKYS---DMQWAIDNFYIG 2857
Cdd:cd08525    89 SWHLVQEECLPSSPGCSElhpsSVYESSTFN---GWKRITIPLPNATLSSATRFRWIQYGYtsgVQTWAIDNVYIG 161

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 163.80 E-value: 7.52e-46

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1451 PSEMFDRF--EGKLSQQWYKITGGQVGTGCGVLSDGKSLYLNGPGKREARTAALDTTNTRLIQFYIQIGNTNGGSTCGKP 1528
Cdd:cd10051     1 KTFLKERFdsEEISSDQWLSLEGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSENNMTLCLRP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1529 KARNEGVVVQYTNDNGISWNLLRELDFMSYLEPQIISIELPRNAKTSGTAFRWWQP--------QHGKQSAQWALDDVLI 1600
Cdd:cd10051    81 TCRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPftisnglvVSGTERAQWALDNILI 160


                  .
gi 212549597 1601 G 1601
Cdd:cd10051   161 G 161

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 161.12 E-value: 4.65e-45

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1452 SEMFDRFEGKLSQQWYKITGGQVGTGCGVLSDGKSLYLNGPGKREARTAALDTTNTRLIQFYIQIGNTNGGSTCGKPKAR 1531
Cdd:cd10045     5 SESFNSSRLSSYHNFSSIRGGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVLGTCPPPDRP 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1532 NEGVVVQYTNDNGISWNLLRELDFMSYLEPQIISIELPRNAKTSGTAFRWWQPQHGKQ-SAQWALDDVLI 1600
Cdd:cd10045    85 GEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQnQDVWALDEISM 154

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 160.75 E-value: 6.06e-45

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1076 FEGLNGWETD-WLEVVGGEIvkpEQGCGIISSGSSMYFYKDGRRQLVSLDMDTTWVDFIQFYIQIGGETT--SCNKPDSR 1152
Cdd:cd10047     5 FDRFEGKLSPlWYKITGGQV---GTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNgeTCLRPRSR 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1153 EEGVLLQYSNNGGINWHLLAEMYFSDFIKSKFVYLELPNAARTPCTRFRWWQPvFSGEGYDQWAIDDVII 1222
Cdd:cd10047    82 NEGIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQP-QHGKPSAQWALDDVLI 150

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 156.93 E-value: 1.55e-43

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1451 PSEMFDRFE--GKLSQQWYKITGGQVGT---GCGVLSDGKSLYLNGPGKREARTAALDTTNTRLIQFYIQIGNtnGGSTC 1525
Cdd:cd10046     2 PSTVMSDFEnqDSLETEWQEVIGGEIVKpemGCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGG--GSASC 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 212549597 1526 GKPKARNEGVVVQYTNDNGISWNLLRELDFMSYLEPQIISIELPRNAKTSGTAFRWWQPQH-GKQSAQWALDDVLIG 1601
Cdd:cd10046    80 NYPDSREEGVLLQYSNNGGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFsGEGYDQWALDDIIIL 156

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 153.53 E-value: 3.29e-42

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  897 CEHDWTLCFTGDSKqasSPRYVETQSMQIGASYMIQFSLVMGCGERYTPhmDNQVMLEYSTNHGLTWHLVQQECLPSMPS 976
Cdd:cd10040    29 LSMDTALMFTENIG---KPRYAETWDFHVSASTFLQFELSMGCSKPYSN--SHSVQLQYSLNNGRDWHLVTEECVPPAIG 103

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 212549597  977 CQEFTSSSIYHSSEFTHWRRITLPLPQKTWSGATRFRWSQRYYTSD-DEWALDNIYIGQQCPNMCSG 1042
Cdd:cd10040   104 CLHYTESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYAPGaDSWAIDNVVLASGCPWMCSG 170

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 149.50 E-value: 4.27e-41

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1075 DFEGLNGwETDWLEVVGGeivKPEQGCGIISSGSSMYFYKD-GRRQLVSLDMDTTWVDFIQFYIQIGgettsCNKPDSRE 1153
Cdd:cd08524     4 DFDGYPS-PDNWLLCPGG---KTGTVCGALSSGNALVFNEPyGPRELVTTDLNTNEASFLQFYIGSG-----CSTPSYSN 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212549597 1154 EGVLLQYSNNGGINWHLLAEMYFSDFIKSKFVYLELPNAARTPCTRFRWWQPVFSGEGYDQWAIDDVII 1222
Cdd:cd08524    75 QPVLLEYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNVLI 143

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 149.21 E-value: 5.35e-41

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1068 LPSTIMSDFEGlNGWETDWLEVVGGEIvkpEQGCGIISSGSSMYFYKDGRRQLVSLDMDTTWVDFIQFYIQIGGETTscn 1147
Cdd:cd10050     1 LPTQLKDTFNR-APSSSNWLTVVGGKL---STVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGCLIP--- 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 212549597 1148 kPDSREEGVLLQYSNNGGINWHLLAEMYFSDFIKSKFVYLELPNAARTPCTRFRWWQPVFSGEGYDQWAIDDVII 1222
Cdd:cd10050    74 -PSNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAIDNVLI 147

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 147.30 E-value: 2.87e-40

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2170 PDFLKDDFEGQ--LESDRFLLVSGG--KTSRKCGILSSGNNLFFNEEGLRMLVTRDLDLSLARFVQFFMRLGCGKA---V 2242
Cdd:cd10046     2 PSTVMSDFENQdsLETEWQEVIGGEivKPEMGCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGGSAscnY 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 212549597 2243 PDPRSQPVLLQFSLDGGLSWSVLQEFHFSNSSNVgRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILIG 2318
Cdd:cd10046    82 PDSREEGVLLQYSNNGGISWKLLAEMYFSDFSKP-RFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALDDIIIL 156

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 147.62 E-value: 3.17e-40

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1063 LPETLLPSTIMSDFeglngwetdWLEVVGGeivKPEQGCGIISSGSSMYFYKDGRRQLVSLDMDTTWVDFIQFYIQIGGE 1142
Cdd:cd10051     4 LKERFDSEEISSDQ---------WLSLEGG---VTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSE 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1143 --TTSCNKPDSREEGVLLQYSNNGGINWHLLAEMYFSDFIKSKFVYLELPNAARTPCTRFRWWQP-------VFSGEGYD 1213
Cdd:cd10051    72 nnMTLCLRPTCRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPftisnglVVSGTERA 151


                  ....*....
gi 212549597 1214 QWAIDDVII 1222
Cdd:cd10051   152 QWALDNILI 160

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 146.12 E-value: 8.30e-40

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  729 FYSIRGAEVSFGCGVLASGKALIFNKDGRRQLITAFLDSSQSRFLQFTLRIGSKSVLSTCKAPDKPGEGVLLHYSHDNGI 808
Cdd:cd10047    16 WYKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNGETCLRPRSRNEGIIVQYSNDNGI 95

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 212549597  809 TWKLMEHYSYLSYHEPRIISVELPEDAKQFGIQFRWWQPYHSGQGEDvWAIDEIIM 864
Cdd:cd10047    96 TWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQHGKPSAQ-WALDDVLI 150

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 145.71 E-value: 1.56e-39

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1451 PSEMFDRFEGKL--SQQWYKITGGQVGTGCGVLS---DGKSLYLNGPGKREARTAALDTTNTRLIQFYIQIGNTNGGSTC 1525
Cdd:cd10052     1 PSYIKDNFESGSvsELKWSLIQGGGIGSGCGQLAphaHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSRSQTDSC 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 212549597 1526 G----KPKARNEGVVVQYTNDNGISWNLLRELDFMSYLEPQIISIELPRNAKTSGTAFRWWQPQH-GKQSAQWALDDV 1598
Cdd:cd10052    81 NinlsSPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHdGTGHDQWALDNV 158

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 143.45 E-value: 7.42e-39

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  734 GAEVSF---GCGVLASGKALIFNKDGRRQLITAFLDSSQSRFLQFTLRIGSKSvlSTCKAPDKPGEGVLLHYSHDNGITW 810
Cdd:cd10046    24 GGEIVKpemGCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGGS--ASCNYPDSREEGVLLQYSNNGGISW 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 212549597  811 KLMEHYSYLSYHEPRIISVELPEDAKQFGIQFRWWQPYHSGQGEDVWAIDEIIM 864
Cdd:cd10046   102 KLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALDDIII 155

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 142.61 E-value: 1.60e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2519 PTQLKDTF-NRAPSSHNWLTVNGGKLSSVCGAVASGMALHFSGGCSRLLVSVDLNLTNAEFVQFYFMYG-------CLIi 2590
Cdd:cd10051     1 KTFLKERFdSEEISSDQWLSLEGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGsennmtlCLR- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2591 PHSRNQGVLLEYSVNGGINWFLLMEIFYDQYSKPGFVNILLPASAKTVGTRFRWWQP-------KHDGLDQNDWAIDNVL 2663
Cdd:cd10051    80 PTCRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPftisnglVVSGTERAQWALDNIL 159


                  ...
gi 212549597 2664 ISG 2666
Cdd:cd10051   160 IGG 162

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 141.17 E-value: 3.53e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2518 LPTQLKDTFNRAPSSHNWLTVNGGKLSSVCG-AVASGMALHFSGGCSRLLVSVDLNLTNAEFVQFYFMYGCLIIPhSRNQ 2596
Cdd:cd10048     1 LPSVLKDDFNGNLRPDLWPEVYGAERGNLNGeTIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKFITKGTP-ERSH 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 212549597 2597 GVLLEYSVNGGINWFLLMEIFYDQYSKPGFVNILLPASAKTVGTRFRWWQPKHDGLDQNDWAIDNVLISGS 2667
Cdd:cd10048    80 SVLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDLVIDGN 150

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 138.40 E-value: 4.51e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1100 GCGIISSGSSMYFYKDGRRQLVSLDMDTTWVDFIQFYIQIG--GETTSCNKPDSREEGVLLQYSNNGGINWHLLAEMYFS 1177
Cdd:cd10045    30 GCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGskSVLGTCPPPDRPGEGVLLHYSCDNGITWKLLEHYSYD 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 212549597 1178 DFIKSKFVYLELPNAARTPCTRFRWWQPVFSGEGYDQWAIDDVII 1222
Cdd:cd10045   110 NYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEISM 154

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 137.72 E-value: 6.45e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1069 PSTIMSDFEGlNGWETDWLEVVGGeivKPEQGCGIISSGSSMYFYKDGRRQLVSLDMDTTWVDFIQFYIQIGgettsCNK 1148
Cdd:cd10049     2 PDFLKDDFEG-QLESDRFLLMSGG---KPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLG-----CGK 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 212549597 1149 --PDSREEGVLLQYSNNGGINWHLLAEMYFSDFIK-SKFVYLELPNAARTPCTRFRWWQPVFSGEGYDQWAIDDVII 1222
Cdd:cd10049    73 gvPDPRSQPVLLQYSLNGGLTWSLLQEFLFSNSSNvGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILI 149

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 136.49 E-value: 1.62e-36

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2898 ERFdsEEIRSDFWLSVDGGKTCTDCGVLAEDMALYFGASAVRQTITQDLDLRGAKFVQYWARIGSENM-TSCRKPVCRKE 2976
Cdd:cd10047     6 DRF--EGKLSPLWYKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNgETCLRPRSRNE 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 212549597 2977 GVLLDYSIDGGITWTLLHEMDYQKYMSVRYDYILLPENAQTNTTRLRWWQPFTvsnglvvlGQERSQWALDNILIG 3052
Cdd:cd10047    84 GIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQH--------GKPSAQWALDDVLIG 151

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 135.79 E-value: 3.04e-36

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2519 PTQLKDTFNRAPSSHNWLTVNGGKLSSVCGAVASGMALHFSGGCSRLLVSVDLNLTNAEFVQFYFMYGC-LIIPHSRNQG 2597
Cdd:cd10049     2 PDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLGCgKGVPDPRSQP 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 212549597 2598 VLLEYSVNGGINWFLLMEIFYDQYSKPG-FVNILLPASAKTVGTRFRWWQPKHDGLDQNDWAIDNVLI 2664
Cdd:cd10049    82 VLLQYSLNGGLTWSLLQEFLFSNSSNVGrYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILI 149

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 135.75 E-value: 3.18e-36

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2535 WLTVNGGKLSSV---CGAVASGMALHFSGGCSRLLVSVDLNLTNAEFVQFYFMYG-----ClIIPHSRNQGVLLEYSVNG 2606
Cdd:cd10046    19 WQEVIGGEIVKPemgCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGggsasC-NYPDSREEGVLLQYSNNG 97

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 212549597 2607 GINWFLLMEIFYDQYSKPGFVNILLPASAKTVGTRFRWWQPKHDGLDQNDWAIDNVLI 2664
Cdd:cd10046    98 GISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALDDIII 155

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 135.73 E-value: 3.19e-36

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2892 LKTFLKERFDSEEIRSDfWLSVDGGKTCTDCGVLAEDMALYFGASAVRQTITQDLDLRGAKFVQYWARIGSENmtscrKP 2971
Cdd:cd10050     1 LPTQLKDTFNRAPSSSN-WLTVVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGCLI-----PP 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2972 VCRKEGVLLDYSIDGGITWTLLHEMDYQKYMSVRYDYILLPENAQTNTTRLRWWQP-FTvsnglvvlGQERSQWALDNIL 3050
Cdd:cd10050    75 SNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPsHD--------GLDQNDWAIDNVL 146


                  ..
gi 212549597 3051 IG 3052
Cdd:cd10050   147 IG 148

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 132.61 E-value: 5.01e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1069 PSTIMSDFEGLNGWETDWLEVVGGEIvkpEQGCGIIS---SGSSMYFYKDGRRQLVSLDMDTTWVDFIQFYIQIGG--ET 1143
Cdd:cd10052     1 PSYIKDNFESGSVSELKWSLIQGGGI---GSGCGQLAphaHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSrsQT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1144 TSCN----KPDSREEGVLLQYSNNGGINWHLLAEMYFSDFIKSKFVYLELPNAARTPCTRFRWWQPVFSGEGYDQWAIDD 1219
Cdd:cd10052    78 DSCNinlsSPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDN 157


                  .
gi 212549597 1220 V 1220
Cdd:cd10052   158 V 158

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 132.25 E-value: 5.23e-35

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2519 PTQLKDTFNRApSSHNWLTVNGGKLSSVCGAVASGMALHFSGGCSRLLVSVDLNLTNAEFVQFYFMYG-------CLIiP 2591
Cdd:cd10047     1 PSEFFDRFEGK-LSPLWYKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGsklngetCLR-P 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 212549597 2592 HSRNQGVLLEYSVNGGINWFLLMEIFYDQYSKPGFVNILLPASAKTVGTRFRWWQPKHdGLDQNDWAIDNVLIS 2665
Cdd:cd10047    79 RSRNEGIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQH-GKPSAQWALDDVLIG 151

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 131.05 E-value: 1.75e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2170 PDFLKDDFEGQ-LESDRFLLVSGGKTSRKCGILSSGNNLFFNEEGLRMLVTRDLDLSLARFVQFFMRLG-------CGKa 2241
Cdd:cd10051     1 KTFLKERFDSEeISSDQWLSLEGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGsennmtlCLR- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2242 vPDPRSQPVLLQFSLDGGLSWSVLQEFHFSNSSNVgRYVALEIPLKARSPSTRLRWWQP--SENGHFYSP-----WVIDQ 2314
Cdd:cd10051    80 -PTCRKEGVLLQYSTDGGISWTLLHELDYQKYISV-RYDYITLPENARTNSTRLRWWQPftISNGLVVSGteraqWALDN 157


                  ....*
gi 212549597 2315 ILIGG 2319
Cdd:cd10051   158 ILIGG 162

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 130.77 E-value: 1.88e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2170 PDFLKDDFEGQLESDRFLLVSGGKTSRKCG-ILSSGNNLFFNEEGLRMLVTRDLDLSLARFVQFFMRLGCgKAVPDpRSQ 2248
Cdd:cd10048     2 PSVLKDDFNGNLRPDLWPEVYGAERGNLNGeTIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKFIT-KGTPE-RSH 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 212549597 2249 PVLLQFSLDGGLSWSVLQEFHFSNSSNVgRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILIGGN 2320
Cdd:cd10048    80 SVLLQYSINGGITWHLIDEFYFPTTTDV-LFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDLVIDGN 150

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 131.07 E-value: 1.92e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  711 PVFISESFTSSRLSSYhNFYSIRGAEVSFGCGVL---ASGKALIFNKDGRRQLITAFLDSSQSRFLQFTLRIGSKSVLST 787
Cdd:cd10052     1 PSYIKDNFESGSVSEL-KWSLIQGGGIGSGCGQLaphAHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSRSQTDS 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212549597  788 CK----APDKPGEGVLLHYSHDNGITWKLMEHYSYLSYHEPRIISVELPEDAKQFGIQFRWWQPYHSGQGEDVWAIDEI 862
Cdd:cd10052    80 CNinlsSPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDNV 158

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 130.34 E-value: 2.49e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1451 PSEMFDRFE-GKLSQQWYKITGGQVGTGCGVLSDGKSLYLNGPGKREARTAALDTTNTRLIQFYIQIGNTNggstcgKPK 1529
Cdd:cd10050     2 PTQLKDTFNrAPSSSNWLTVVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGCLI------PPS 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 212549597 1530 ARNEGVVVQYTNDNGISWNLLRELDFMSYLEPQIISIELPRNAKTSGTAFRWWQPQH-GKQSAQWALDDVLIG 1601
Cdd:cd10050    76 NRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHdGLDQNDWAIDNVLIG 148

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 130.30 E-value: 3.21e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2519 PTQLKDTFNRAPSSH-NWLTVNGGKLSSVCGAV---ASGMALHFSGGCSRLLVSVDLNLTNAEFVQFYFMYG-------C 2587
Cdd:cd10052     1 PSYIKDNFESGSVSElKWSLIQGGGIGSGCGQLaphAHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGsrsqtdsC 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 212549597 2588 ---LIIPHSRNQGVLLEYSVNGGINWFLLMEIFYDQYSKPGFVNILLPASAKTVGTRFRWWQPKHDGLDQNDWAIDNV 2662
Cdd:cd10052    81 ninLSSPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDNV 158

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 129.47 E-value: 3.50e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  721 SRLSSYHNFYSIRGAEVSFGCGVLASGKALIFNKD-GRRQLITAFLDSSQSRFLQFTLRIGsksvlstCKAPDKPGEGVL 799
Cdd:cd08524     6 DGYPSPDNWLLCPGGKTGTVCGALSSGNALVFNEPyGPRELVTTDLNTNEASFLQFYIGSG-------CSTPSYSNQPVL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 212549597  800 LHYSHDNGITWKLMEHYSYLSYHEPRIISVELPEDAKQFGIQFRWWQPYHSGQGEDVWAIDEI 862
Cdd:cd08524    79 LEYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNV 141

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 129.09 E-value: 5.11e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2896 LKERFDSEEiRSDFWLSVDGGKTCTDCGVLAEDMALYF-GASAVRQTITQDLDLRGAKFVQYWARIGsenmtsCRKPVCR 2974
Cdd:cd08524     1 LKDDFDGYP-SPDNWLLCPGGKTGTVCGALSSGNALVFnEPYGPRELVTTDLNTNEASFLQFYIGSG------CSTPSYS 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 212549597 2975 KEGVLLDYSIDGGITWTLLHEMDYQKYMSVRYDYILLPENAQTNTTRLRWWQPFTvsnglvvLGQERSQWALDNILIG 3052
Cdd:cd08524    74 NQPVLLEYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNH-------RGVYQATWAIDNVLIG 144

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 128.80 E-value: 7.23e-34

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2170 PDFLKDDFEGQLESDRFLLVSGGKTSRKCGILSSGNNLFFNEEGLRMLVTRDLDLSLARFVQFFMRLGCgKAVPDPRSQP 2249
Cdd:cd10050     2 PTQLKDTFNRAPSSSNWLTVVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGC-LIPPSNRNQG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212549597 2250 VLLQFSLDGGLSWSVLQEFhFSNSSNVGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILIG 2318
Cdd:cd10050    81 VLLEYSVNGGITWNLLMEI-FYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAIDNVLIG 148

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 128.31 E-value: 1.02e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1808 LKDDFNGNLHPDLWPEVYGGERGNLNGeTIKSGTALIFKGD-GLRMLISRDLDCTHTLYIQFSFKFITKGTPERSHSILL 1886
Cdd:cd08524     1 LKDDFDGYPSPDNWLLCPGGKTGTVCG-ALSSGNALVFNEPyGPRELVTTDLNTNEASFLQFYIGSGCSTPSYSNQPVLL 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 212549597 1887 QYSISGGITWHLMDEFYFTQTTDVLFVNVPLPNTAQTNATRFRLWQPYHNGKKDEVWIIEDFVI 1950
Cdd:cd08524    80 EYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNVLI 143

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 128.81 E-value: 1.06e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2892 LKTFLKERFDSEEIRSDFWLSVDGGKTCTD---CGVLAEDMALYFGASAVRQTITQDLDLRGAKFVQYWARIGSENmTSC 2968
Cdd:cd10046     1 LPSTVMSDFENQDSLETEWQEVIGGEIVKPemgCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGGS-ASC 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2969 RKPVCRKEGVLLDYSIDGGITWTLLHEMDYQKYMSVRYDYILLPENAQTNTTRLRWWQPftvsnglVVLGQERSQWALDN 3048
Cdd:cd10046    80 NYPDSREEGVLLQYSNNGGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQP-------VFSGEGYDQWALDD 152


                  ....
gi 212549597 3049 ILIG 3052
Cdd:cd10046   153 IIIL 156

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 127.59 E-value: 2.74e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  711 PVFISESFTSSRLSSyHNFYSIRGAEVSFGCGVLASGKALIFNKDGRRQLITAFLDSSQSRFLQFTLRIGSKSVLSTCKA 790
Cdd:cd10051     1 KTFLKERFDSEEISS-DQWLSLEGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSENNMTLCLR 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212549597  791 PDKPGEGVLLHYSHDNGITWKLMEHYSYLSYHEPRIISVELPEDAKQFGIQFRWWQPY-------HSGQGEDVWAIDEI 862
Cdd:cd10051    80 PTCRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPFtisnglvVSGTERAQWALDNI 158

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 126.86 E-value: 3.33e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3269 PSYIKDNFEsEKVTEInWENIQGGVIGNGCGQLSpyaHGDSLYFNGCQIRQAITKPLDLTRASKIMFVLQIGSIAQTDSC 3348
Cdd:cd10047     1 PSEFFDRFE-GKLSPL-WYKITGGQVGTGCGVIK---DGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNGETC 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 212549597 3349 NTNLSDtntvDKAVLLQYSVNNGITWQVIAQHQPKDFIQAQRVSYNIPLEARMKGVLLRWWQPRHnGIGHDQWALDHV 3426
Cdd:cd10047    76 LRPRSR----NEGIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQH-GKPSAQWALDDV 148

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 126.45 E-value: 6.82e-33

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2895 FLKERFDSEeiRSDF---WLSVDGGKTCTDCGVLAEDMALYFGASAVRQTITQDLDLRGAKFVQYWARIGSENMTS-CRK 2970
Cdd:cd10045     3 FLSESFNSS--RLSSyhnFSSIRGGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVLGtCPP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2971 PVCRKEGVLLDYSIDGGITWTLLHEMDYQKYMSVRYDYILLPENAQTNTTRLRWWQPFTVSNGLVVlgqersqWALDNIL 3050
Cdd:cd10045    81 PDRPGEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDV-------WALDEIS 153


                  .
gi 212549597 3051 I 3051
Cdd:cd10045   154 M 154

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 125.30 E-value: 1.74e-32

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2519 PTQLKDTFN--RAPSSHNWLTVNGGKLSSVCGAVASGMALHFSGGCSRLLVSVDLNLTNAEFVQF------YFMYGCLII 2590
Cdd:cd10045     1 PGFLSESFNssRLSSYHNFSSIRGGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFtlrlgsKSVLGTCPP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 212549597 2591 PHSRNQGVLLEYSVNGGINWFLLMEIFYDQYSKPGFVNILLPASAKTVGTRFRWWQPKHDGLDQNDWAIDNVLIS 2665
Cdd:cd10045    81 PDRPGEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEISMT 155

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 124.91 E-value: 2.24e-32

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2170 PDFLKDDFEGQLES--DRFLLVSGGKTSRKCGILSSGNNLFFNEEGLRMLVTRDLDLSLARFVQFFMRLGCGKAV----- 2242
Cdd:cd10045     1 PGFLSESFNSSRLSsyHNFSSIRGGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVLgtcpp 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 212549597 2243 PDPRSQPVLLQFSLDGGLSWSVLQEFHFSNSSNvGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILI 2317
Cdd:cd10045    81 PDRPGEGVLLHYSCDNGITWKLLEHYSYDNYHE-PRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEISM 154

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 122.25 E-value: 1.32e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1804 LPSILKDDFNGNLHPDLWPEVYGGERGNLNGEtIKSGTALIFKGDGLRMLISRDLDCTHTLYIQFSFKFITKGTPE-RSH 1882
Cdd:cd10050     1 LPTQLKDTFNRAPSSSNWLTVVGGKLSTVCGA-VASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGCLIPPSnRNQ 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 212549597 1883 SILLQYSISGGITWHLMDEFYFTQTTDVLFVNVPLPNTAQTNATRFRLWQPYHNGKKDEVWIIEDFVI 1950
Cdd:cd10050    80 GVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAIDNVLI 147

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 121.83 E-value: 2.20e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3269 PSYIKDNFESEKVTEI-NWENIQGGVIGNGCGQLspyAHGDSLYFNGCQIRQAITKPLDLTRASKIMFVLQIGSIAQTDS 3347
Cdd:cd10045     1 PGFLSESFNSSRLSSYhNFSSIRGGEVGFGCGVL---ASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVLGT 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212549597 3348 CNTnlsdTNTVDKAVLLQYSVNNGITWQVIAQHQPKDFIQAQRVSYNIPLEARMKGVLLRWWQPRHNGIGHDQWALDHV 3426
Cdd:cd10045    78 CPP----PDRPGEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEI 152

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 121.55 E-value: 4.69e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2328 EDDFS-SLDNK-KWLLHPGGTKMSVCGSSGDALVFIEKA-STRYVVTTDIVVNEDSFLQIDFAASCS-VTDSCYAIELEY 2403
Cdd:cd10040     3 QDKFDgSVDLQaNWYRIQGGQVDIDCLSMDTALMFTENIgKPRYAETWDFHVSASTFLQFELSMGCSkPYSNSHSVQLQY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2404 SVDLGLSWNPVLKDCLPTNVECSNYQLQRALVSDTFNKWTRFTLPLPPYTRSQATRFRWNQPSPFDKQQTWAIDNVYIGD 2483
Cdd:cd10040    83 SLNNGRDWHLVTEECVPPAIGCLHYTESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYAPGADSWAIDNVVLAS 162


                  ....*...
gi 212549597 2484 GCVDMCSG 2491
Cdd:cd10040   163 GCPWMCSG 170

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 120.71 E-value: 5.04e-31

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  711 PVFISESFtsSRLSSYHNFYSIRGAEVSFGCGVLASGKALIFNKDGRRQLITAFLDSSQSRFLQFTLRIGSKSVlstcka 790
Cdd:cd10050     2 PTQLKDTF--NRAPSSSNWLTVVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGCLIP------ 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 212549597  791 PDKPGEGVLLHYSHDNGITWKLMEHYSYLSYHEPRIISVELPEDAKQFGIQFRWWQPYHSGQGEDVWAIDEIIM 864
Cdd:cd10050    74 PSNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAIDNVLI 147

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 118.06 E-value: 4.04e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1068 LPSTIMSDFEGlNGWETDWLEVVGGEivKPEQGCGIISSGSSMYFYKDGRRQLVSLDMDTTWVDFIQFYIQIggettSCN 1147
Cdd:cd10048     1 LPSVLKDDFNG-NLRPDLWPEVYGAE--RGNLNGETIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKF-----ITK 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 212549597 1148 KPDSREEGVLLQYSNNGGINWHLLAEMYFSDFIKSKFVYLELPNAARTPCTRFRWWQPVFSGEGYDQWAIDDVII 1222
Cdd:cd10048    73 GTPERSHSVLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDLVI 147

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 118.41 E-value: 4.17e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3268 LPSYIKDNFESEKVTEINWENIQGGVI---GNGCGQLSpyaHGDSLYFNGCQIRQAITKPLDLTRASKIMFVLQIGsiAQ 3344
Cdd:cd10046     1 LPSTVMSDFENQDSLETEWQEVIGGEIvkpEMGCGVIS---SGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIG--GG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3345 TDSCNTNLSDTNtvdkAVLLQYSVNNGITWQVIAQHQPKDFIQAQRVSYNIPLEARMKGVLLRWWQPRHNGIGHDQWALD 3424
Cdd:cd10046    76 SASCNYPDSREE----GVLLQYSNNGGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALD 151


                  ..
gi 212549597 3425 HV 3426
Cdd:cd10046   152 DI 153

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 118.08 E-value: 4.49e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1805 PSILKDDFNGNLHPDLWPEVYGGERGNLNGeTIKSGTALIFKGDGLRMLISRDLDCTHTLYIQFSFKF-ITKGTPE-RSH 1882
Cdd:cd10049     2 PDFLKDDFEGQLESDRFLLMSGGKPSRKCG-ILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLgCGKGVPDpRSQ 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212549597 1883 SILLQYSISGGITWHLMDEFYFT-QTTDVLFVNVPLPNTAQTNATRFRLWQPYHNGKKDEVWIIEDFVI 1950
Cdd:cd10049    81 PVLLQYSLNGGLTWSLLQEFLFSnSSNVGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILI 149

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 117.69 E-value: 5.67e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1450 NPSEMFDRFEGKL-SQQWYKITGGQVGTGCGVLSDGKSLYLNGPGKREARTAALDTTNTRLIQFYIQIGntnggstCGK- 1527
Cdd:cd10049     1 NPDFLKDDFEGQLeSDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLG-------CGKg 73

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 212549597 1528 -PKARNEGVVVQYTNDNGISWNLLRELDFM-SYLEPQIISIELPRNAKTSGTAFRWWQP-QHGKQSAQWALDDVLIG 1601
Cdd:cd10049    74 vPDPRSQPVLLQYSLNGGLTWSLLQEFLFSnSSNVGRYVALEIPLKARSPSTRLRWWQPsENGHFYSPWVIDQILIG 150

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 117.64 E-value: 7.45e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1804 LPSILKDDF-NGNLHPDLWPEVYGGE--RGNLNGETIKSGTALIFKGDGLRMLISRDLDCTHTLYIQFSFKfITKGTPE- 1879
Cdd:cd10046     1 LPSTVMSDFeNQDSLETEWQEVIGGEivKPEMGCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQ-IGGGSASc 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 212549597 1880 -----RSHSILLQYSISGGITWHLMDEFYFTQTTDVLFVNVPLPNTAQTNATRFRLWQPYHNGKKDEVWIIEDFVI 1950
Cdd:cd10046    80 nypdsREEGVLLQYSNNGGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALDDIII 155

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 116.92 E-value: 1.06e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  711 PVFISESFTSSRLSSyhNFYSIRGAEVSFGCGVLASGKALIFNKDGRRQLITAFLDSSQSRFLQFTLRIGSKSvlstcKA 790
Cdd:cd10049     2 PDFLKDDFEGQLESD--RFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLGCGK-----GV 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 212549597  791 PDKPGEGVLLHYSHDNGITWKLMEHYSYL-SYHEPRIISVELPEDAKQFGIQFRWWQPYHSGQGEDVWAIDEIIM 864
Cdd:cd10049    75 PDPRSQPVLLQYSLNGGLTWSLLQEFLFSnSSNVGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQILI 149

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 116.42 E-value: 2.07e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3269 PSYIKDNFESEKVTEINWENIQGGVIGNGCGQLspyAHGDSLYFNGCQIRQAITKPLDLTRASKIMFVLQIGSIAQTDSC 3348
Cdd:cd10051     1 KTFLKERFDSEEISSDQWLSLEGGVTCTDCGVL---AEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSENNMTLC 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3349 NTNLSDTntvdKAVLLQYSVNNGITWQVIAQHQPKDFIQAQRVSYNIPLEARMKGVLLRWWQP--RHNGIG-----HDQW 3421
Cdd:cd10051    78 LRPTCRK----EGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPftISNGLVvsgteRAQW 153


                  ....*
gi 212549597 3422 ALDHV 3426
Cdd:cd10051   154 ALDNI 158

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 115.30 E-value: 4.90e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2170 PDFLKDDFEGQLeSDRFLLVSGGKTSRKCGILSSGNNLFFNEEGLRMLVTRDLDLSLARFVQFFMRLG-------CGKav 2242
Cdd:cd10047     1 PSEFFDRFEGKL-SPLWYKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGsklngetCLR-- 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 212549597 2243 PDPRSQPVLLQFSLDGGLSWSVLQEFHFSnSSNVGRYVALEIPLKARSPSTRLRWWQPSENGHfYSPWVIDQILIG 2318
Cdd:cd10047    78 PRSRNEGIIVQYSNDNGITWHLLRELDFM-SYLEPQVISIELPREAKTPATAFRWWQPQHGKP-SAQWALDDVLIG 151

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 114.55 E-value: 6.91e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3268 LPSYIKDNFESEKVTEiNWENIQGGVIGNGCGqlsPYAHGDSLYFNGCQIRQAITKPLDLTRASKIMFVLQIGsiaqtds 3347
Cdd:cd10050     1 LPTQLKDTFNRAPSSS-NWLTVVGGKLSTVCG---AVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYG------- 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212549597 3348 CNTNLSDTNTvdkAVLLQYSVNNGITWQVIAQHQPKDFIQAQRVSYNIPLEARMKGVLLRWWQPRHNGIGHDQWALDHV 3426
Cdd:cd10050    70 CLIPPSNRNQ---GVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAIDNV 145

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 114.19 E-value: 1.01e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  928 SYMIQFSLVMGCGeryTPHMDNQVMLEYSTNHGLTWHLVQQECLPSMPSCQEFTSSSIYHSSEFTHWRRITLPLPQKTWS 1007
Cdd:cd10037    44 THFAQFSINLGCG---SHQPGNSVSLEFSTNHGRSWSLLHTECLPELCAGPHLPHSTVYSSDNYSGWNRITIPLPNAALT 120

                          90       100
                  ....*....|....*....|....*.
gi 212549597 1008 GATRFRWSQRYYTSDDEWALDNIYIG 1033
Cdd:cd10037   121 SATRFRWRQTGSVVGSMWAIDNVYIG 146

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 114.63 E-value: 1.22e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1652 PRYAETWDFHVMPSSSLQFNLNMGCSKQLSNSH--VVQLQFSVNNGRDWQQVTEECIPPSIGCLHYTESSVYSSERFQTS 1729
Cdd:cd10038    46 ARYVETQSMQIGASYMIQFSLVMGCGQQYTPHMdnQVKLEYSTNHGLTWHLVQEECLPGMPSCQEFTSGSIYHSSEFTEW 125

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 212549597 1730 KRITVYLPSATVSPRTRFRWIQYNYGSGaDAWAIDNVVLSSGCP 1773
Cdd:cd10038   126 RRITLPLPQKTWSSATRFRWSQSYYTDQ-DEWALDNIYIGQQCP 168

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 112.68 E-value: 3.83e-28

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2895 FLKERFDSEeIRSDFWLSVDGGKTCTDCGVLAEDMALYFGASAVRQTITQDLDLRGAKFVQYWARIGsenmTSCRKPVCR 2974
Cdd:cd10049     4 FLKDDFEGQ-LESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLG----CGKGVPDPR 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212549597 2975 KEGVLLDYSIDGGITWTLLHEMDYQKYMSV-RYDYILLPENAQTNTTRLRWWQPFTVsnglvvlGQERSQWALDNILIG 3052
Cdd:cd10049    79 SQPVLLQYSLNGGLTWSLLQEFLFSNSSNVgRYVALEIPLKARSPSTRLRWWQPSEN-------GHFYSPWVIDQILIG 150

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 111.93 E-value: 1.19e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  572 SHMVQFSINLGCGSH-QPG--NSVRLEFSTNHGRSWSLLHSECLPELCAGSHLPHSTIYSSDNYSGWNRITIPLPNAALT 648
Cdd:cd10038    59 SYMIQFSLVMGCGQQyTPHmdNQVKLEYSTNHGLTWHLVQEECLPGMPSCQEFTSGSIYHSSEFTEWRRITLPLPQKTWS 138

                          90       100
                  ....*....|....*....|....*....
gi 212549597  649 RDTRLRWRQNGPVMGNMWALDNIYIGPSC 677
Cdd:cd10038   139 SATRFRWSQSYYTDQDEWALDNIYIGQQC 167

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 110.66 E-value: 2.73e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2170 PDFLKDDFE-GQLESDRFLLVSGGKTSRKCGILS---SGNNLFFNEEGLRMLVTRDLDLSLARFVQFFMRLG-------C 2238
Cdd:cd10052     1 PSYIKDNFEsGSVSELKWSLIQGGGIGSGCGQLAphaHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGsrsqtdsC 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212549597 2239 GKAV--PDPRSQPVLLQFSLDGGLSWSVLQEfHFSNSSNVGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQI 2315
Cdd:cd10052    81 NINLssPRAVDKAVLLQYSVNNGITWYLIAQ-HQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDNV 158

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 108.28 E-value: 9.16e-27

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3272 IKDNFESeKVTEINWENIQGGVIGNGCGQLSpyaHGDSLYFNGCQ-IRQAITKPLDLTRASKIMFVLQIGSIAQTDSCnt 3350
Cdd:cd08524     1 LKDDFDG-YPSPDNWLLCPGGKTGTVCGALS---SGNALVFNEPYgPRELVTTDLNTNEASFLQFYIGSGCSTPSYSN-- 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 212549597 3351 nlsdtntvdKAVLLQYSVNNGITWQVIAQHQPKDFIQAQRVSYNIPLEARMKGVLLRWWQPRHNGIGHDQWALDHV 3426
Cdd:cd08524    75 ---------QPVLLEYSVDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNV 141

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 108.84 E-value: 1.20e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  570 TESHMVQFSINLGCG-SHQPGNSVRLEFSTNHGRSWSLLHSECLPELCAGSHLPHSTIYSSDNYSGWNRITIPLPNAALT 648
Cdd:cd10040    55 SASTFLQFELSMGCSkPYSNSHSVQLQYSLNNGRDWHLVTEECVPPAIGCLHYTESSVYSSERFQNWKRITVYLPPATIS 134

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 212549597  649 RDTRLRWRQ-NGPVMGNMWALDNIYIGPSCLKFCSG 683
Cdd:cd10040   135 PRTRFRWIQpNYAPGADSWAIDNVVLASGCPWMCSG 170

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 107.96 E-value: 1.80e-26

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2894 TFLKERFDSEEIRSDFWLSVDGGKTCTDCGVL---AEDMALYFGASAVRQTITQDLDLRGAKFVQYWARIGSENMT-SCR 2969
Cdd:cd10052     2 SYIKDNFESGSVSELKWSLIQGGGIGSGCGQLaphAHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSRSQTdSCN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2970 ----KPVCRKEGVLLDYSIDGGITWTLLHEMDYQKYMSVRYDYILLPENAQTNTTRLRWWQPFTVSNGlvvlgqeRSQWA 3045
Cdd:cd10052    82 inlsSPRAVDKAVLLQYSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHDGTG-------HDQWA 154


                  ....
gi 212549597 3046 LDNI 3049
Cdd:cd10052   155 LDNV 158

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 104.25 E-value: 4.80e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  915 PRYVETQSMQIGASYMIQFSLVMGCGERyTPHMDNQVMLEYSTNHGLTWHLVQQECLPSMPSC-QEFTSSSIYHSSEftH 993
Cdd:cd10043    57 EVSAVTHDLTPTEGWILQFKISVGCKSS-EKSAQQPVHVQYSTDFGVSWSYVTPQCLPSDPKCgGSVTQPSVFFPSK--G 133

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 212549597  994 WRRITLPLPQKTWSGATRFRWSQRYytSDDEWALDNIYIG 1033
Cdd:cd10043   134 WRRVTIPLPDKLVGRPIRFRFYQKA--SDMQWALDNFYIG 171

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 104.13 E-value: 6.07e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  916 RYVETQSMQIGASYMIQFSLVMGCGERYTpHMdNQVMLEYSTNHGLTWHLVQQECLPSMPS---CQ----EFTSSSIYHS 988
Cdd:cd10039    46 RFAVTRDLTLKPGYVLQFKVNIGCTSEFS-SF-APVLLQYSHDAGLTWSLVREGCYPASPGskgCEgssrELREPTVYHT 123

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 212549597  989 SEFTHWRRITLPLPQKTWSGATRFRWSQRY--YTSDDEWALDNIYIG 1033
Cdd:cd10039   124 GDYEDWTRITIPIPRSLAASKTRFRWIQESssLKNAPPFGLDGVYIS 170

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 102.96 E-value: 9.73e-25

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1805 PSILKDDFNGNL--HPDLWPEVYGGERGNLNGeTIKSGTALIFKGDGLRMLISRDLDCTHTLYIQFSFKFITKGT----- 1877
Cdd:cd10045     1 PGFLSESFNSSRlsSYHNFSSIRGGEVGFGCG-VLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGSKSVlgtcp 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 212549597 1878 -PER-SHSILLQYSISGGITWHLMDEFYFTQTTDVLFVNVPLPNTAQTNATRFRLWQPYHNGKKDEVWIIEDFVI 1950
Cdd:cd10045    80 pPDRpGEGVLLHYSCDNGITWKLLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEISM 154

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 102.68 E-value: 1.21e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  913 SSPRYVETQSMQIGASYMIQFSLVMGCGERYTPHmdnQVMLEYSTNHGLTWHLVQQECLPSMPSCQEFTSSSIYHSSEFT 992
Cdd:cd10042    39 ASTRYVVTTDIMVNEDSFLQIDFAASCSVTDSCY---AIELEYSVDLGLSWHPLLRDCLPTNVECSSYHLQRILVSDTFN 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 212549597  993 HWRRITLPLPQKTWSGATRFRWSQ-RYYTSDDEWALDNIYIG 1033
Cdd:cd10042   116 KWTRVTLPLPHYTRSQATRFRWHQpAPFDKQQTWAIDNVYIG 157

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 102.99 E-value: 1.54e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1272 FCSLTPSAMIFGKSDGDRF---AVTRDLTLKPGYVLQFKLNVGC--TNEFSGMAPVLLQYSHDAGL-SWSLVREGCYPAS 1345
Cdd:cd10044    31 FCGNPSFHLTWPNKKKDKThnaLTTRQLIVQPGYMIQFKIVVGCgsVSSCGDLHPVMLEYTTDPRSdHWQLVQTECLPSS 110

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212549597 1346 PGIKDCegSSRELGEPTSYYTGDYEDWTRITIVIPRSLASSKTRFRWIQESSSfSNVPAFGLDGVYISE 1414
Cdd:cd10044   111 SNSIDC--SPFQYHEASIYSSVNSSVWKRVTIQLPDHVSSSATQFRWIQKTES-TEAPSWAIDDVYIGE 176

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 102.61 E-value: 2.35e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  920 TQSMQIGASYMIQFSLVMGCGERYTPHMDNQVMLEYSTN-HGLTWHLVQQECLPS---MPSCQEFT--SSSIYHSSEFTH 993
Cdd:cd10044    55 TRQLIVQPGYMIQFKIVVGCGSVSSCGDLHPVMLEYTTDpRSDHWQLVQTECLPSssnSIDCSPFQyhEASIYSSVNSSV 134

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 212549597  994 WRRITLPLPQKTWSGATRFRWSQR-YYTSDDEWALDNIYIGQ 1034
Cdd:cd10044   135 WKRVTIQLPDHVSSSATQFRWIQKtESTEAPSWAIDDVYIGE 176

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 102.17 E-value: 3.16e-24

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1278 SAMIFGKSD-GDRFAVTRDLTLKPGYVLQFKLNVGCTNEFSGMAPVLLQYSHDAGLSWSLVREGCYPASPGIKDCegsSR 1356
Cdd:cd10041    39 SAMVFVSSElGEHSITTRDLDVNENTIIQFEINVGCTTESSSADPVRLEFSRDFGATWHLLLPLCYGSSSISSLC---ST 115

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 212549597 1357 ELGEPTSYYTGDYEDWTRITIVIPRSLASSKTRFRWIQE-SSSFSNVPAFGLDGVYI 1412
Cdd:cd10041   116 ELHPSSVYYTGTTQGWRREVILFGKLHLCGSVRFRWYQGfHPAGSQPVTWAIDNVYI 172

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 100.38 E-value: 1.18e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3109 ILSSRELIIQPGYMIQFKIVVGC--DVSSCVDlHSVMLEYTKDARTdSWQLVQTQCLPSSsnsVGCSPFlfHEASIYNSV 3186
Cdd:cd10038    48 YVETQSMQIGASYMIQFSLVMGCgqQYTPHMD-NQVKLEYSTNHGL-TWHLVQEECLPGM---PSCQEF--TSGSIYHSS 120

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 212549597 3187 NSSVWKRVTLQLPDYVSSSATQFRWIQKgDETEKQSWAVDHVYIGEACP 3235
Cdd:cd10038   121 EFTEWRRITLPLPQKTWSSATRFRWSQS-YYTDQDEWALDNIYIGQQCP 168

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 99.89 E-value: 1.18e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1805 PSILKDDFNGNLhPDLWPEVYGGERGNLNGeTIKSGTALIFKGDGLRMLISRDLDCTHTLYIQFSFKFITKGTPE----- 1879
Cdd:cd10047     1 PSEFFDRFEGKL-SPLWYKITGGQVGTGCG-VIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKLNGEtclrp 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 212549597 1880 --RSHSILLQYSISGGITWHLMDEFYFTQTTDVLFVNVPLPNTAQTNATRFRLWQPYHnGKKDEVWIIEDFVI 1950
Cdd:cd10047    79 rsRNEGIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQH-GKPSAQWALDDVLI 150

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 99.99 E-value: 1.54e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2364 ASTRYVVTTDIVVNEDSFLQIDFAASCSVTDSC---YAIELEYSVDLGLSWNPVLKDCLPTNVECSNYQLQRALVSDTFN 2440
Cdd:cd10038    44 SSARYVETQSMQIGASYMIQFSLVMGCGQQYTPhmdNQVKLEYSTNHGLTWHLVQEECLPGMPSCQEFTSGSIYHSSEFT 123

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 212549597 2441 KWTRFTLPLPPYTRSQATRFRWNQpSPFDKQQTWAIDNVYIGDGC 2485
Cdd:cd10038   124 EWRRITLPLPQKTWSSATRFRWSQ-SYYTDQDEWALDNIYIGQQC 167

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 98.42 E-value: 3.02e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1451 PSEMFDRFEGKL-SQQWYKITGGQVGTGCGV-LSDGKSLYLNGPGKREARTAALDTTNTRLIQFYIQIgntnggSTCGKP 1528
Cdd:cd10048     2 PSVLKDDFNGNLrPDLWPEVYGAERGNLNGEtIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKF------ITKGTP 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 212549597 1529 KaRNEGVVVQYTNDNGISWNLLRELDFMSYLEPQIISIELPRNAKTSGTAFRWWQPQH-GKQSAQWALDDVLIGMN 1603
Cdd:cd10048    76 E-RSHSVLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNsGKKEEVWILDDLVIDGN 150

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 98.70 E-value: 3.17e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1805 PSILKDDF-NGNLHPDLWPEVYGGERGNLNGeTIKSGTALIFKGDGLRMLISRDLDCTHTLYIQFSFKFITKGTPE---- 1879
Cdd:cd10051     1 KTFLKERFdSEEISSDQWLSLEGGVTCTDCG-VLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSENNMTlclr 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1880 ---RSHSILLQYSISGGITWHLMDEFYFTQTTDVLFVNVPLPNTAQTNATRFRLWQPYHNGKKDEV-------WIIEDFV 1949
Cdd:cd10051    80 ptcRKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPFTISNGLVVsgteraqWALDNIL 159


                  ...
gi 212549597 1950 IDG 1952
Cdd:cd10051   160 IGG 162

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 99.21 E-value: 3.36e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1242 FYEKpaFDYPVNQMNVWLMLanEGMPKNESFCSLTPSAMIFGKSDGDRFAVTRDLTLKPGYVLQFKLNVGCTNEFSGMAP 1321
Cdd:cd10040     2 FQDK--FDGSVDLQANWYRI--QGGQVDIDCLSMDTALMFTENIGKPRYAETWDFHVSASTFLQFELSMGCSKPYSNSHS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1322 VLLQYSHDAGLSWSLVREGCYPASPGikdCEGSSrelgEPTSYYTGDYEDWTRITIVIPRSLASSKTRFRWIQESSSfSN 1401
Cdd:cd10040    78 VQLQYSLNNGRDWHLVTEECVPPAIG---CLHYT----ESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYA-PG 149

                         170       180
                  ....*....|....*....|.
gi 212549597 1402 VPAFGLDGVYISEPCPSYCNG 1422
Cdd:cd10040   150 ADSWAIDNVVLASGCPWMCSG 170

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 98.83 E-value: 4.36e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3063 DTFDdegTSHDEHWSFY--PNAVRTAGFCGNPSFHLYWPNKKKDKthnILSSRELIIQPGYMIQFKIVVGCDvSSCVDLH 3140
Cdd:cd10040     4 DKFD---GSVDLQANWYriQGGQVDIDCLSMDTALMFTENIGKPR---YAETWDFHVSASTFLQFELSMGCS-KPYSNSH 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3141 SVMLEYTKDARTDsWQLVQTQCLPSSsnsVGCSPFlfHEASIYNSVNSSVWKRVTLQLPDYVSSSATQFRWIQKGDETEK 3220
Cdd:cd10040    77 SVQLQYSLNNGRD-WHLVTEECVPPA---IGCLHY--TESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYAPGA 150

                         170       180
                  ....*....|....*....|
gi 212549597 3221 QSWAVDHVYIGEACPKLCSG 3240
Cdd:cd10040   151 DSWAIDNVVLASGCPWMCSG 170

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 98.76 E-value: 4.68e-23

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1958 PAILLDTFDFGPN--EENWFFYPGGNI-ALYCpytskGSPEedSAMVFVSNEVG--EHSITTRDLDVDENTIIQFEINVG 2032
Cdd:cd10044     1 PSSLVETFEDEGTshDENWEFYPNGVRtDEFC-----GNPS--FHLTWPNKKKDktHNALTTRQLIVQPGYMIQFKIVVG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2033 CTSDSSSAD--PVKLEFSRDFGAT-WHLLLPLCYSSSSHISSLCSTEHHPSSTYYAGTTQGWRREVINFGKLRLCGSIRF 2109
Cdd:cd10044    74 CGSVSSCGDlhPVMLEYTTDPRSDhWQLVQTECLPSSSNSIDCSPFQYHEASIYSSVNSSVWKRVTIQLPDHVSSSATQF 153

                         170       180
                  ....*....|....*....|....
gi 212549597 2110 RWYQGFYPITMQPvtWAIDNIYIG 2133
Cdd:cd10044   154 RWIQKTESTEAPS--WAIDDVYIG 175

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 96.34 E-value: 1.50e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1612 DKFDGSvDLHANWYRIQGGQVDVDC--LSMDTALLFNENIGkPRYAETWDFHVMPSSSLQFNLNMGCSKQLSNSHVVQLQ 1689
Cdd:cd08524     3 DDFDGY-PSPDNWLLCPGGKTGTVCgaLSSGNALVFNEPYG-PRELVTTDLNTNEASFLQFYIGSGCSTPSYSNQPVLLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1690 FSVNNGRDWQQVTEecippsigclhytessvYSSERFQTSKRITVYLPSATVSPRTRFRWIQYNYGSGADA-WAIDNVVL 1768
Cdd:cd08524    81 YSVDNGASWHLLEE-----------------IRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQAtWAIDNVLI 143


                  .
gi 212549597 1769 S 1769
Cdd:cd08524   144 G 144

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 96.43 E-value: 2.63e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3112 SRELIIQPGYMIQFKIVVGCdVSSCVDLHSVMLEYTKDARTdSWQLVQTQCLPSSSNSVGC--SPFLFHEASIYNSVNSS 3189
Cdd:cd10039    50 TRDLTLKPGYVLQFKVNIGC-TSEFSSFAPVLLQYSHDAGL-TWSLVREGCYPASPGSKGCegSSRELREPTVYHTGDYE 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 212549597 3190 VWKRVTLQLPDYVSSSATQFRWIQKGD-ETEKQSWAVDHVYIG 3231
Cdd:cd10039   128 DWTRITIPIPRSLAASKTRFRWIQESSsLKNAPPFGLDGVYIS 170

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 95.33 E-value: 4.08e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  744 LASGKALIFNKDGRRQLITAFLDSSQSRFLQFTLRIGSKSVLSTCKApdkpgegVLLHYSHDNGITWKLMEHYSYLSYHE 823
Cdd:cd10048    34 IKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKFITKGTPERSHS-------VLLQYSINGGITWHLIDEFYFPTTTD 106

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 212549597  824 PRIISVELPEDAKQFGIQFRWWQPYHSGQGEDVWAIDEIIM 864
Cdd:cd10048   107 VLFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDLVI 147

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 95.37 E-value: 5.39e-22

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1272 FCSLTPSAMIFGKSD---GDRFAVTRDLTLKPGYVLQFKLNVGCTNEFS-GM-APVLLQYSHDAGLSWSLVREGCYPASP 1346
Cdd:cd10038    27 YCNHDWTLCFTGDSKhasSARYVETQSMQIGASYMIQFSLVMGCGQQYTpHMdNQVKLEYSTNHGLTWHLVQEECLPGMP 106

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 212549597 1347 GikdCEgssrELGEPTSYYTGDYEDWTRITIVIPRSLASSKTRFRWIQesSSFSNVPAFGLDGVYISEPCP 1417
Cdd:cd10038   107 S---CQ----EFTSGSIYHSSEFTEWRRITLPLPQKTWSSATRFRWSQ--SYYTDQDEWALDNIYIGQQCP 168

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 94.91 E-value: 1.04e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2329 DDFSSLDNKKWLLHPGGTKMS-VCGSSGDALVFI--EKASTRYVVTT-DIVVNEDSFLQIDFAASCSVTDSC---YAIEL 2401
Cdd:cd10044     9 EDEGTSHDENWEFYPNGVRTDeFCGNPSFHLTWPnkKKDKTHNALTTrQLIVQPGYMIQFKIVVGCGSVSSCgdlHPVML 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2402 EYSVD-LGLSWNPVLKDCLPTNVE---CSNYQLQRALV--SDTFNKWTRFTLPLPPYTRSQATRFRWNQPSPFDKQQTWA 2475
Cdd:cd10044    89 EYTTDpRSDHWQLVQTECLPSSSNsidCSPFQYHEASIysSVNSSVWKRVTIQLPDHVSSSATQFRWIQKTESTEAPSWA 168


                  ....*...
gi 212549597 2476 IDNVYIGD 2483
Cdd:cd10044   169 IDDVYIGE 176

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 94.62 E-value: 1.27e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1234 TYPTMPQNFYEK-PAFDYPVNQMnvWLMLANEGMpknESFCSLTPSAMIFGKSDGDR--FAVTRDLTLKPGYVLQFKLNV 1310
Cdd:cd10043     5 TFSSANLPQHERsPEDKTTVNDH--WLFHDNCSI---ERFCDSPDGVMICGSHDDGRevSAVTHDLTPTEGWILQFKISV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1311 GC-TNEFSGMAPVLLQYSHDAGLSWSLVREGCYPASPgikDCEGSsreLGEPTSYYTgdYEDWTRITIVIPRSLASSKTR 1389
Cdd:cd10043    80 GCkSSEKSAQQPVHVQYSTDFGVSWSYVTPQCLPSDP---KCGGS---VTQPSVFFP--SKGWRRVTIPLPDKLVGRPIR 151

                         170       180
                  ....*....|....*....|...
gi 212549597 1390 FRWIQESSSFSnvpaFGLDGVYI 1412
Cdd:cd10043   152 FRFYQKASDMQ----WALDNFYI 170

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 94.21 E-value: 1.68e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2745 YTVTHDLTPAEGWIMQFKIAVGC-RSSEKNVQNQVHVQYSTDFGVSWTYLVPQCLPADPKCSgTVSQPSVFFPA--KGWK 2821
Cdd:cd10038    48 YVETQSMQIGASYMIQFSLVMGCgQQYTPHMDNQVKLEYSTNHGLTWHLVQEECLPGMPSCQ-EFTSGSIYHSSefTEWR 126

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 212549597 2822 RVTYTLPDSLIGNPVRFRFYQKY--SDMQWAIDNFYIGPGC 2860
Cdd:cd10038   127 RITLPLPQKTWSSATRFRWSQSYytDQDEWALDNIYIGQQC 167

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 93.02 E-value: 2.57e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2892 LKTFLKERFDsEEIRSDFWLSVDGGKTCTDCGVLAED-MALYFGASAVRQTITQDLDLRGAKFVQYWARIgsenmtSCRK 2970
Cdd:cd10048     1 LPSVLKDDFN-GNLRPDLWPEVYGAERGNLNGETIKSgTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKF------ITKG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2971 PVCRKEGVLLDYSIDGGITWTLLHEMDYQKYMSVRYDYILLPENAQTNTTRLRWWQPFTVsnglvvlGQERSQWALDNIL 3050
Cdd:cd10048    74 TPERSHSVLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNS-------GKKEEVWILDDLV 146


                  ...
gi 212549597 3051 IGG 3053
Cdd:cd10048   147 IDG 149

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 92.49 E-value: 2.88e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  891 GNVQPYC---EHDWTLCFTGDSkqasSPRYVETQSMQIGASYMIQFSLVMGCGeryTPHMDNQ-VMLEYSTNHGLTWHLV 966
Cdd:cd08524    20 GKTGTVCgalSSGNALVFNEPY----GPRELVTTDLNTNEASFLQFYIGSGCS---TPSYSNQpVLLEYSVDNGASWHLL 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212549597  967 QqeclpsmpscqeftsssIYHSSEFTHWRRITLPLPQKTWSGATRFRWSQRYYTSDDE--WALDNIYIG 1033
Cdd:cd08524    93 E-----------------EIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQatWAIDNVLIG 144

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 91.81 E-value: 9.92e-21

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1629 GGQVDVDCLSMDTALLFNENIGKpRYAETWDFHVMPSSSLQFNLNMGCSKQLSNSHVVQLQFSVNNGRDWQQVTEECIPP 1708
Cdd:cd10039    23 GMGKNESCSPTPSAMVFGKSDGD-RFAVTRDLTLKPGYVLQFKVNIGCTSEFSSFAPVLLQYSHDAGLTWSLVREGCYPA 101

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212549597 1709 SIGCLHYT-------ESSVYSSERFQTSKRITVYLPSATVSPRTRFRWIQYNYG-SGADAWAIDNVVLS 1769
Cdd:cd10039   102 SPGSKGCEgssrelrEPTVYHTGDYEDWTRITIPIPRSLAASKTRFRWIQESSSlKNAPPFGLDGVYIS 170

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 90.30 E-value: 2.14e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1660 FHVMP------SSSLQFNLNMGC-SKQLSNShvVQLQFSVNNGRDWQQVTEECIPPSIGCLHYTESSVYSSERFQTSKRI 1732
Cdd:cd10037    33 FHLLPvlpstvTHFAQFSINLGCgSHQPGNS--VSLEFSTNHGRSWSLLHTECLPELCAGPHLPHSTVYSSDNYSGWNRI 110

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 212549597 1733 TVYLPSATVSPRTRFRWIQYNYGSGaDAWAIDNVVL 1768
Cdd:cd10037   111 TIPLPNAALTSATRFRWRQTGSVVG-SMWAIDNVYI 145

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 90.67 E-value: 3.16e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  571 ESHMVQFSINLGCGSHQPGN---SVRLEFSTN-HGRSWSLLHSECLPEL-----CAGSHLPHSTIYSSDNYSGWNRITIP 641
Cdd:cd10044    62 PGYMIQFKIVVGCGSVSSCGdlhPVMLEYTTDpRSDHWQLVQTECLPSSsnsidCSPFQYHEASIYSSVNSSVWKRVTIQ 141

                          90       100       110
                  ....*....|....*....|....*....|....
gi 212549597  642 LPNAALTRDTRLRWRQNG-PVMGNMWALDNIYIG 674
Cdd:cd10044   142 LPDHVSSSATQFRWIQKTeSTEAPSWAIDDVYIG 175

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 89.96 E-value: 3.40e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3269 PSYIKDNFESEKVTEiNWENIQGGVIGNGCGQLSPyahGDSLYFNGCQIRQAITKPLDLTRASKIMFVLQIGsiaqtdsC 3348
Cdd:cd10049     2 PDFLKDDFEGQLESD-RFLLMSGGKPSRKCGILSS---GNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLG-------C 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212549597 3349 NTNLSDTNTvdKAVLLQYSVNNGITWQVIAQ-HQPKDFIQAQRVSYNIPLEARMKGVLLRWWQPRHNGIGHDQWALDHV 3426
Cdd:cd10049    71 GKGVPDPRS--QPVLLQYSLNGGLTWSLLQEfLFSNSSNVGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVIDQI 147

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 89.19 E-value: 5.64e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1623 NWYRIQGGQVDVDCLSMDTALLFNENiGKPRYAETWDFHVMPSSSLQFNLNMGCSKQlSNSHVVQLQFSVNNGRDWQQVT 1702
Cdd:cd10042    13 KWLLHPGGTKMPVCGSTGDALVFIEK-ASTRYVVTTDIMVNEDSFLQIDFAASCSVT-DSCYAIELEYSVDLGLSWHPLL 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 212549597 1703 EECIPPSIGCLHYTESSVYSSERFQTSKRITVYLPSATVSPRTRFRWIQYNYGSGADAWAIDNV 1766
Cdd:cd10042    91 RDCLPTNVECSSYHLQRILVSDTFNKWTRVTLPLPHYTRSQATRFRWHQPAPFDKQQTWAIDNV 154

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 89.85 E-value: 6.84e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  918 VETQSMQIGASYMIQFSLVMGCGERYTPhmDNQVMLEYSTNHGLTWHLVQQEC----LPSMPSCQEFTSSSIYHSSEFTH 993
Cdd:cd10041    53 ITTRDLDVNENTIIQFEINVGCTTESSS--ADPVRLEFSRDFGATWHLLLPLCygssSISSLCSTELHPSSVYYTGTTQG 130

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 212549597  994 WRRITLPLPQKTWSGATRFRWSQRYYTSDDE---WALDNIYIG 1033
Cdd:cd10041   131 WRREVILFGKLHLCGSVRFRWYQGFHPAGSQpvtWAIDNVYIG 173

Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins; This domain is found at the N-terminus of F-spondin, a protein attached to the extracellular matrix, which plays roles in neuronal development and vascular remodelling. The F-spondin reeler domain has been reported to bind heparin. The reeler domain is also found at the N-terminus of reelin, an extracellular glycoprotein involved in the development of the brain cortex, and in a variety of other eukaryotic proteins with different domain architectures, including the animal ferric-chelate reductase 1 or stromal cell-derived receptor 2, a member of the cytochrome B561 family, which reduces ferric iron before its transport from the endosome to the cytoplasm. Also included is the insect putative defense protein 1, which is expressed upon bacterial infection and appears to contain a single reeler domain.

Pssm-ID: 260081 Cd Length: 135 Bit Score: 88.21 E-value: 7.43e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597   51 GDGEQGEVLISLHLAGNpgYYVPGQEYHVTIS--TSTFFDGLLVTglytSTSVQASQSIGGskaFGFGIMSDRQFGTQFM 128
Cdd:cd08544    12 GDPQTTPSPYSITVSGN--TYKPGQTYTVTLSgsRPTPFRGFLLQ----ARDASSNEPVGT---FQLPPDSGTKLLTCCP 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 212549597  129 CSVVASHVSHLPTTNLSFVWIAPPAGTGCVNFMATATHRGQVIFKDALAQQLC 181
Cdd:cd08544    83 SGNAVTHTNNSPKTSVTVTWKAPSNGSGCVTFRATVVQSYDVFWVDVLSKTLC 135

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 89.22 E-value: 9.90e-20

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1960 ILLDTFDFGP-------------NEENWFFYPGGNIALYCPytskgSPeeDSAMVFVSNEVGEH-SITTRDLDVDENTII 2025
Cdd:cd10043     1 VLLDTFSSANlpqherspedkttVNDHWLFHDNCSIERFCD-----SP--DGVMICGSHDDGREvSAVTHDLTPTEGWIL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2026 QFEINVGC-TSDSSSADPVKLEFSRDFGATWHLLLPLCYsssshisslcstehhPSSTYYAGT---------TQGWRREV 2095
Cdd:cd10043    74 QFKISVGCkSSEKSAQQPVHVQYSTDFGVSWSYVTPQCL---------------PSDPKCGGSvtqpsvffpSKGWRRVT 138

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 212549597 2096 INFGKLRLCGSIRFRWYQGFypitmQPVTWAIDNIYIG 2133
Cdd:cd10043   139 IPLPDKLVGRPIRFRFYQKA-----SDMQWALDNFYIG 171

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 89.11 E-value: 1.05e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2726 FCDSP-DGVMICGSHDGrEVYTVTHDLTPAEGWIMQFKIAVGCrSSEKNVQNQVHVQYSTDFGVSWTYLVPQCLPADP-- 2802
Cdd:cd10039    28 ESCSPtPSAMVFGKSDG-DRFAVTRDLTLKPGYVLQFKVNIGC-TSEFSSFAPVLLQYSHDAGLTWSLVREGCYPASPgs 105

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 212549597 2803 -KCSGT---VSQPSVFFPA--KGWKRVTYTLPDSLIGNPVRFRFYQKYSDMQ----WAIDNFYIG 2857
Cdd:cd10039   106 kGCEGSsreLREPTVYHTGdyEDWTRITIPIPRSLAASKTRFRWIQESSSLKnappFGLDGVYIS 170

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 89.08 E-value: 1.22e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2712 NKHWLFHDDCSIERFC-------DSPDGVMICGSHDGREVYTVTHDLTPAEGWIMQFKIAVGCrSSEKNVQNQVHVQYST 2784
Cdd:cd10041    12 ESNWLFYPGGNTGLYCpyqskgaPEEDSAMVFVSSELGEHSITTRDLDVNENTIIQFEINVGC-TTESSSADPVRLEFSR 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2785 DFGVSWTYLVPQCLPADP---KCSGTVSQPSVFFPA--KGWKRVTYTLPDSLIGNPVRFRFYQKY-----SDMQWAIDNF 2854
Cdd:cd10041    91 DFGATWHLLLPLCYGSSSissLCSTELHPSSVYYTGttQGWRREVILFGKLHLCGSVRFRWYQGFhpagsQPVTWAIDNV 170


                  ....
gi 212549597 2855 YIGP 2858
Cdd:cd10041   171 YIGP 174

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 88.05 E-value: 1.39e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  205 LRDDFDSYKLQELNpniWLQCRNCEVGEQCGVIMHSGAVTFCDPyGPRELISVQMNTTTASVLQFS--IGSGSCRFSYSD 282
Cdd:cd08526     2 LKDSFEGSLSSSDN---WSLVSGGEVGTGCGVLASGKALYFNGP-GLRQLVTVDLDLTNARFVQFYlrIGSKSQTSTCNP 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 212549597  283 P-----GIVVSYTKNNSSSWVPLERISaPSNVSTIIHI-IYLPPEVKGDSVKFRWRQEnmQAGDVYEACWALDNILI 353
Cdd:cd08526    78 PdsrseGVLLQYSVNGGITWHLLQELY-YDQYSEPRFVsIELPLEARTNGTRFRWWQP--SHSGKGQDQWALDNILI 151

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 87.92 E-value: 2.90e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  570 TESHMVQFSINLGC----GSHQPgnsVRLEFSTNHGRSWSLLHSEC-----LPELCAGSHLPHSTIYSSDNySGWNRITI 640
Cdd:cd10041    61 NENTIIQFEINVGCttesSSADP---VRLEFSRDFGATWHLLLPLCygsssISSLCSTELHPSSVYYTGTT-QGWRREVI 136

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 212549597  641 PLPNAALTRDTRLRWRQ---NGPVMGNMWALDNIYIGP 675
Cdd:cd10041   137 LFGKLHLCGSVRFRWYQgfhPAGSQPVTWAIDNVYIGP 174

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 86.88 E-value: 3.82e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  570 TESHMVQFSINLGCGSHQPGNSVRLEFSTNHGRSWSLLHSECLPEL--CAGSHLphSTIYSSDNYSGWNRITIPLPNAAL 647
Cdd:cd10042    52 NEDSFLQIDFAASCSVTDSCYAIELEYSVDLGLSWHPLLRDCLPTNveCSSYHL--QRILVSDTFNKWTRVTLPLPHYTR 129

                          90       100
                  ....*....|....*....|....*...
gi 212549597  648 TRDTRLRWRQNGPV-MGNMWALDNIYIG 674
Cdd:cd10042   130 SQATRFRWHQPAPFdKQQTWAIDNVYIG 157

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 86.91 E-value: 5.50e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3070 TSHDEHWSFYPNAVrTAGFCGNPSfHLYWPNKKKDKTHNILSSRELIIQPGYMIQFKIVVGCDVSSCVDLHSVMLEYTKD 3149
Cdd:cd10043    22 TTVNDHWLFHDNCS-IERFCDSPD-GVMICGSHDDGREVSAVTHDLTPTEGWILQFKISVGCKSSEKSAQQPVHVQYSTD 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3150 aRTDSWQLVQTQCLPSS---SNSVGCSPFLFheasiynsvNSSVWKRVTLQLPDYVSSSATQFRWIQKGDETEkqsWAVD 3226
Cdd:cd10043   100 -FGVSWSYVTPQCLPSDpkcGGSVTQPSVFF---------PSKGWRRVTIPLPDKLVGRPIRFRFYQKASDMQ---WALD 166


                  ....*
gi 212549597 3227 HVYIG 3231
Cdd:cd10043   167 NFYIG 171

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 86.80 E-value: 6.21e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1965 FDFGPNEEN-WFFYPGGNIALYCPYTSKGSpeedsAMVFVSNEvGEHSITTRDLDVDENTIIQFEINVGCTSDSSSADPV 2043
Cdd:cd10039     6 FDYPLNQMSvWLMLSNEGMGKNESCSPTPS-----AMVFGKSD-GDRFAVTRDLTLKPGYVLQFKVNIGCTSEFSSFAPV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2044 KLEFSRDFGATWHLLLPLCYSSSSHISS--LCSTEHHPSSTYYAGTTQGWRREVINFGKLRLCGSIRFRWYQGFYPITMQ 2121
Cdd:cd10039    80 LLQYSHDAGLTWSLVREGCYPASPGSKGceGSSRELREPTVYHTGDYEDWTRITIPIPRSLAASKTRFRWIQESSSLKNA 159

                         170
                  ....*....|..
gi 212549597 2122 PvTWAIDNIYIG 2133
Cdd:cd10039   160 P-PFGLDGVYIS 170

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 85.68 E-value: 7.89e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3121 YMIQFKIVVGCdvSSCVDLHSVMLEYTKDaRTDSWQLVQTQCLPSSsnsvgCS-PFLFHeASIYNSVNSSVWKRVTLQLP 3199
Cdd:cd10037    45 HFAQFSINLGC--GSHQPGNSVSLEFSTN-HGRSWSLLHTECLPEL-----CAgPHLPH-STVYSSDNYSGWNRITIPLP 115

                          90       100       110
                  ....*....|....*....|....*....|..
gi 212549597 3200 DYVSSSATQFRWIQKGDETEKQsWAVDHVYIG 3231
Cdd:cd10037   116 NAALTSATRFRWRQTGSVVGSM-WAIDNVYIG 146

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 85.64 E-value: 1.41e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  575 VQFSINLGCGSHQPG-NSVRLEFSTNHGRSWSLLHSECLP-----ELCAGS--HLPHSTIYSSDNYSGWNRITIPLPNAA 646
Cdd:cd10039    61 LQFKVNIGCTSEFSSfAPVLLQYSHDAGLTWSLVREGCYPaspgsKGCEGSsrELREPTVYHTGDYEDWTRITIPIPRSL 140

                          90       100       110
                  ....*....|....*....|....*....|
gi 212549597  647 LTRDTRLRWRQNGPVMGNM--WALDNIYIG 674
Cdd:cd10039   141 AASKTRFRWIQESSSLKNAppFGLDGVYIS 170

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 84.99 E-value: 2.73e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  570 TESHMVQFSINLGCGS--HQPGNSVRLEFSTNHGRSWSLLHSECLPE--LCAGSHLPHSTIYSSdnySGWNRITIPLPNA 645
Cdd:cd10043    68 TEGWILQFKISVGCKSseKSAQQPVHVQYSTDFGVSWSYVTPQCLPSdpKCGGSVTQPSVFFPS---KGWRRVTIPLPDK 144

                          90       100
                  ....*....|....*....|....*....
gi 212549597  646 ALTRDTRLRWRQNGPVMgnMWALDNIYIG 674
Cdd:cd10043   145 LVGRPIRFRFYQKASDM--QWALDNFYIG 171

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 83.80 E-value: 5.39e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3066 DDEGTSHDEH-WSFYPNAVRTAgFCGNPSFHLYWpnKKKDKTHNILSSrELIIQPGYMIQFKIVVGCDV-SSCvdlHSVM 3143
Cdd:cd10042     3 EDDFSTLDSRkWLLHPGGTKMP-VCGSTGDALVF--IEKASTRYVVTT-DIMVNEDSFLQIDFAASCSVtDSC---YAIE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3144 LEYTKDARTdSWQLVQTQCLPSSsnsVGCSPFlfHEASIYNSVNSSVWKRVTLQLPDYVSSSATQFRWIQKGDETEKQSW 3223
Cdd:cd10042    76 LEYSVDLGL-SWHPLLRDCLPTN---VECSSY--HLQRILVSDTFNKWTRVTLPLPHYTRSQATRFRWHQPAPFDKQQTW 149


                  ....*...
gi 212549597 3224 AVDHVYIG 3231
Cdd:cd10042   150 AIDNVYIG 157

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 83.69 E-value: 6.16e-18

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1805 PSILKDDFNGNLHPDL-WPEVYGGERGNLNGETIK--SGTALIFKGDGLRMLISRDLDCTHTLYIQFSFKF--------- 1872
Cdd:cd10052     1 PSYIKDNFESGSVSELkWSLIQGGGIGSGCGQLAPhaHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIgsrsqtdsc 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212549597 1873 -ITKGTPE-RSHSILLQYSISGGITWHLMDEF---YFTQTTDVlFVNVPLPntAQTNATRFRLWQPYHNGKKDEVWIIE 1946
Cdd:cd10052    81 nINLSSPRaVDKAVLLQYSVNNGITWYLIAQHqpkDFMRAQRV-SYNLPLE--ARTKGVVLRWWQPRHDGTGHDQWALD 156

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 83.42 E-value: 1.01e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1963 DTFD-FGPNEENWFFYPGGNIALYCPytskgspEEDSAMVFVSNEVGEHSITTRDLDVDENTIIQFEINVGCTSDSSSAD 2041
Cdd:cd10040     4 DKFDgSVDLQANWYRIQGGQVDIDCL-------SMDTALMFTENIGKPRYAETWDFHVSASTFLQFELSMGCSKPYSNSH 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2042 PVKLEFSRDFGATWHLLLPLCYSSSSHISslcstEHHPSSTYYAGTTQGWRREVINFGKLRLCGSIRFRWYQGFYPITMQ 2121
Cdd:cd10040    77 SVQLQYSLNNGRDWHLVTEECVPPAIGCL-----HYTESSVYSSERFQNWKRITVYLPPATISPRTRFRWIQPNYAPGAD 151

                         170       180
                  ....*....|....*....|.
gi 212549597 2122 pvTWAIDNIYIGPQCEEMCNG 2142
Cdd:cd10040   152 --SWAIDNVVLASGCPWMCSG 170

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 82.91 E-value: 1.74e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2326 VIEDDFSSL-DNKKWLLHPGGTKMSVC-----GSSGD--ALVFIEKASTRYVVTT-DIVVNEDSFLQIDFAASCSV-TDS 2395
Cdd:cd10041     1 LLLDTFDFGpNESNWLFYPGGNTGLYCpyqskGAPEEdsAMVFVSSELGEHSITTrDLDVNENTIIQFEINVGCTTeSSS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2396 CYAIELEYSVDLGLSWNPVLKDCL---PTNVECSnYQLQRALV--SDTFNKWTRFTLPLPPYTRSQATRFRWNQP--SPF 2468
Cdd:cd10041    81 ADPVRLEFSRDFGATWHLLLPLCYgssSISSLCS-TELHPSSVyyTGTTQGWRREVILFGKLHLCGSVRFRWYQGfhPAG 159

                         170
                  ....*....|....
gi 212549597 2469 DKQQTWAIDNVYIG 2482
Cdd:cd10041   160 SQPVTWAIDNVYIG 173

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 81.71 E-value: 1.96e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  567 LPSTESHMVQFSINLGCGSHQPGN-SVRLEFSTNHGRSWSLLhseclpelcagshlphsTIYSSDNYSGWNRITIPLPNA 645
Cdd:cd08524    51 LNTNEASFLQFYIGSGCSTPSYSNqPVLLEYSVDNGASWHLL-----------------EEIRADSFSKWRIIILYLPED 113

                          90       100       110
                  ....*....|....*....|....*....|.
gi 212549597  646 ALTRDTRLRWRQNGP--VMGNMWALDNIYIG 674
Cdd:cd08524   114 AKSGATRFRWWQPNHrgVYQATWAIDNVLIG 144

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 82.26 E-value: 1.98e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1970 NEENWFFYPGGNIALYCPYTSkgspeedSAMVFVSNEVGEHSITTrDLDVDENTIIQFEINVGCTSdSSSADPVKLEFSR 2049
Cdd:cd10042    10 DSRKWLLHPGGTKMPVCGSTG-------DALVFIEKASTRYVVTT-DIMVNEDSFLQIDFAASCSV-TDSCYAIELEYSV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2050 DFGATWHLLLPLCYSSSSHIsslcsTEHHPSSTYYAGTTQGWRREVINFGKLRLCGSIRFRWYQgfyPITMQPV-TWAID 2128
Cdd:cd10042    81 DLGLSWHPLLRDCLPTNVEC-----SSYHLQRILVSDTFNKWTRVTLPLPHYTRSQATRFRWHQ---PAPFDKQqTWAID 152


                  ....*
gi 212549597 2129 NIYIG 2133
Cdd:cd10042   153 NVYIG 157

C-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197343 [Multi-domain] Cd Length: 152 Bit Score: 81.12 E-value: 3.15e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  424 SEEFENLPA----GWEIVGAVIGTECGTIESGASLVFLKDGERRVCTPYMDTTGYGNLRFHFVMGGM-----CSPGESHE 494
Cdd:cd08526     3 KDSFEGSLSssdnWSLVSGGEVGTGCGVLASGKALYFNGPGLRQLVTVDLDLTNARFVQFYLRIGSKsqtstCNPPDSRS 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 212549597  495 NDVLLYAQIDGRKDRIVMDTLAYSSYKAPSLVSSVISPDLQTPATKFCLKQNNHRGHNLNVWAVD 559
Cdd:cd08526    83 EGVLLQYSVNGGITWHLLQELYYDQYSEPRFVSIELPLEARTNGTRFRWWQPSHSGKGQDQWALD 147

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 81.06 E-value: 3.33e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2377 NEDSFLQIDFAASCSVTDSCYAIELEYSVDLGLSWNPVLKDCLPTNveCSNYQLQRALV--SDTFNKWTRFTLPLPPYTR 2454
Cdd:cd10037    42 TVTHFAQFSINLGCGSHQPGNSVSLEFSTNHGRSWSLLHTECLPEL--CAGPHLPHSTVysSDNYSGWNRITIPLPNAAL 119

                          90       100
                  ....*....|....*....|....*...
gi 212549597 2455 SQATRFRWNQPSPFDKQQtWAIDNVYIG 2482
Cdd:cd10037   120 TSATRFRWRQTGSVVGSM-WAIDNVYIG 146

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 81.52 E-value: 4.12e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2335 DNKKWLLHPGGTKMSVCGSSGDALVFIEKASTR--YVVTTDIVVNEDSFLQIDFAASCSVTD--SCYAIELEYSVDLGLS 2410
Cdd:cd10043    24 VNDHWLFHDNCSIERFCDSPDGVMICGSHDDGRevSAVTHDLTPTEGWILQFKISVGCKSSEksAQQPVHVQYSTDFGVS 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 212549597 2411 WNPVLKDCLPTNVECSNYQLQRAlVSDTFNKWTRFTLPLPPYTRSQATRFRWNQPSpfdKQQTWAIDNVYIG 2482
Cdd:cd10043   104 WSYVTPQCLPSDPKCGGSVTQPS-VFFPSKGWRRVTIPLPDKLVGRPIRFRFYQKA---SDMQWALDNFYIG 171

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 81.40 E-value: 5.48e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2344 GGTKMSVCGSSGDALVFIEKASTRYVVTTDIVVNEDSFLQIDFAASCSVTDSCYA-IELEYSVDLGLSWNPVLKDCLP-- 2420
Cdd:cd10039    23 GMGKNESCSPTPSAMVFGKSDGDRFAVTRDLTLKPGYVLQFKVNIGCTSEFSSFApVLLQYSHDAGLTWSLVREGCYPas 102

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 212549597 2421 -TNVEC--SNYQLQRALVSDT--FNKWTRFTLPLPPYTRSQATRFRWNQP-SPFDKQQTWAIDNVYIG 2482
Cdd:cd10039   103 pGSKGCegSSRELREPTVYHTgdYEDWTRITIPIPRSLAASKTRFRWIQEsSSLKNAPPFGLDGVYIS 170

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 81.37 E-value: 6.02e-17

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3061 LVDTFDdEGtSHDEHWSFYPNAvRTAGFC--------GNPSFHLYWPNKKKDktHNIlSSRELIIQPGYMIQFKIVVGCD 3132
Cdd:cd10041     2 LLDTFD-FG-PNESNWLFYPGG-NTGLYCpyqskgapEEDSAMVFVSSELGE--HSI-TTRDLDVNENTIIQFEINVGCT 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3133 VSSCvDLHSVMLEYTKDARTdSWQLVQTQCLPSSSNSVGCSpFLFHEASIYNSVNSSVWKRVTLQLPDYVSSSATQFRWI 3212
Cdd:cd10041    76 TESS-SADPVRLEFSRDFGA-TWHLLLPLCYGSSSISSLCS-TELHPSSVYYTGTTQGWRREVILFGKLHLCGSVRFRWY 152

                         170       180
                  ....*....|....*....|.
gi 212549597 3213 Q--KGDETEKQSWAVDHVYIG 3231
Cdd:cd10041   153 QgfHPAGSQPVTWAIDNVYIG 173

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 79.39 E-value: 1.19e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1278 SAMIFGKSDGDRFAVTRDLTLKPGYVLQFKLNVGCTNEFSGMAPVLLQYSHDAGLSWSLVREgcypaspgikdcegssre 1357
Cdd:cd08524    33 NALVFNEPYGPRELVTTDLNTNEASFLQFYIGSGCSTPSYSNQPVLLEYSVDNGASWHLLEE------------------ 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 212549597 1358 lgeptsYYTGDYEDWTRITIVIPRSLASSKTRFRWIQESSSFSNVPAFGLDGVYIS 1413
Cdd:cd08524    95 ------IRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNVLIG 144

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 79.50 E-value: 2.61e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1646 NENIGKPRYAETWDFHVMPSSSLQFNLNMGC--SKQLSNSHVVQLQFSVNNGRD-WQQVTEECIPP---SIGC--LHYTE 1717
Cdd:cd10044    44 KKKDKTHNALTTRQLIVQPGYMIQFKIVVGCgsVSSCGDLHPVMLEYTTDPRSDhWQLVQTECLPSssnSIDCspFQYHE 123

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 212549597 1718 SSVYSSERFQTSKRITVYLPSATVSPRTRFRWIQYNYGSGADAWAIDNV 1766
Cdd:cd10044   124 ASIYSSVNSSVWKRVTIQLPDHVSSSATQFRWIQKTESTEAPSWAIDDV 172

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 78.34 E-value: 5.64e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2702 EMFSEDKTTVNKHWLFHDDCSI-ERFCDSPDGVMICGSH--DGREVYTVTHDLTPAEGWIMQFKIAVGCRS-SEKNVQNQ 2777
Cdd:cd10044     6 ETFEDEGTSHDENWEFYPNGVRtDEFCGNPSFHLTWPNKkkDKTHNALTTRQLIVQPGYMIQFKIVVGCGSvSSCGDLHP 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2778 VHVQYSTD-FGVSWTYLVPQCLPAD---PKCSG-TVSQPSVFFPAKG--WKRVTYTLPDSLIGNPVRFRFYQKYSDM--- 2847
Cdd:cd10044    86 VMLEYTTDpRSDHWQLVQTECLPSSsnsIDCSPfQYHEASIYSSVNSsvWKRVTIQLPDHVSSSATQFRWIQKTESTeap 165

                         170
                  ....*....|
gi 212549597 2848 QWAIDNFYIG 2857
Cdd:cd10044   166 SWAIDDVYIG 175

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 77.57 E-value: 5.85e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2325 TVIEDDFS-SLDNKKWLLHPGGTKMSVCG--SSGDALVFiEKASTRYVVTTDIVVNEDSFLQIDFAASCSVTDSC--YAI 2399
Cdd:cd10050     3 TQLKDTFNrAPSSSNWLTVVGGKLSTVCGavASGTALHF-SGGCSRQLVTVDLNLTNAEFVQFYFMYGCLIPPSNrnQGV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2400 ELEYSVDLGLSWNPVLKdclptnvecsnyqlqraLVSDTFNKWTRFTLPLPPYTRSQATRFRWNQPSpFD--KQQTWAID 2477
Cdd:cd10050    82 LLEYSVNGGITWNLLME-----------------IFYDQYSKPGFVNILLPPEARGVGTRFRWWQPS-HDglDQNDWAID 143


                  ....*
gi 212549597 2478 NVYIG 2482
Cdd:cd10050   144 NVLIG 148

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 76.81 E-value: 1.28e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  414 LSSEDIQDQWSEEfenlpaGWEIVGAVIGTE---CGTIESGASLVFLKDGERRVCTPYMDTTGYGNLRFHFVMGG---MC 487
Cdd:cd10046     6 MSDFENQDSLETE------WQEVIGGEIVKPemgCGVISSGSSLYFNKDGLRQLVSWDLDTTWVDFIQFYIQIGGgsaSC 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 212549597  488 SPGESHENDVLLYAQIDGRKDRIVMDTLAYSSYKAPSLVSSVISPDLQTPATKFCLKQNNHRGHNLNVWAVDFVHVL 564
Cdd:cd10046    80 NYPDSREEGVLLQYSNNGGISWKLLAEMYFSDFSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEGYDQWALDDIIIL 156

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 77.27 E-value: 1.41e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1980 GNIALYCPYTS----KGSPEEDSAMVFVSnevgehsitTRDLDVDENTIIQFEINVGCTSDSSSA--DPVKLEFSRDFGA 2053
Cdd:cd10038    22 GNVQPYCNHDWtlcfTGDSKHASSARYVE---------TQSMQIGASYMIQFSLVMGCGQQYTPHmdNQVKLEYSTNHGL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2054 TWHLLLPLCyssssHISSLCSTEHHPSSTYYAGTTQGWRREVINFGKLRLCGSIRFRWYQGFYpitMQPVTWAIDNIYIG 2133
Cdd:cd10038    93 TWHLVQEEC-----LPGMPSCQEFTSGSIYHSSEFTEWRRITLPLPQKTWSSATRFRWSQSYY---TDQDEWALDNIYIG 164


                  ...
gi 212549597 2134 PQC 2136
Cdd:cd10038   165 QQC 167

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 76.10 E-value: 2.18e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1273 CSLTPSAMIFGKSDGDRFAVTRDLTLKPGYVLQFKLNVGCTNEFSGMApVLLQYSHDAGLSWSLVREGCYPASpgikdCE 1352
Cdd:cd10042    26 CGSTGDALVFIEKASTRYVVTTDIMVNEDSFLQIDFAASCSVTDSCYA-IELEYSVDLGLSWHPLLRDCLPTN-----VE 99

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 212549597 1353 GSSRELgepTSYYTGD-YEDWTRITIVIPRSLASSKTRFRWIQeSSSFSNVPAFGLDGVYI 1412
Cdd:cd10042   100 CSSYHL---QRILVSDtFNKWTRVTLPLPHYTRSQATRFRWHQ-PAPFDKQQTWAIDNVYI 156

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 75.69 E-value: 2.57e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3268 LPSYIKDNFESEKVTEInWENIQGGVIGNGCGQlsPYAHGDSLYFNGCQIRQAITKPLDLTRASKIMFVLQIgsIAQTDS 3347
Cdd:cd10048     1 LPSVLKDDFNGNLRPDL-WPEVYGAERGNLNGE--TIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKF--ITKGTP 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 212549597 3348 CNTNlsdtntvdkAVLLQYSVNNGITWQVIAQHQPKDFIQAQRVSYNIPLEARMKGVLLRWWQPRHNGIGHDQWALD 3424
Cdd:cd10048    76 ERSH---------SVLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILD 143

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 74.90 E-value: 4.89e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1288 DRFAVTRDLTLKPGYVLQFKLNVGCTNEFSGMApVLLQYSHDAGLSWSLVREGCYPASpgikdCEGSsrELGEPTSYYTG 1367
Cdd:cd10037    31 DFFHLLPVLPSTVTHFAQFSINLGCGSHQPGNS-VSLEFSTNHGRSWSLLHTECLPEL-----CAGP--HLPHSTVYSSD 102

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 212549597 1368 DYEDWTRITIVIPRSLASSKTRFRWIQESSSFSNVPAfgLDGVYI 1412
Cdd:cd10037   103 NYSGWNRITIPLPNAALTSATRFRWRQTGSVVGSMWA--IDNVYI 145

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 74.51 E-value: 6.73e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2738 SHDGREV-------YTVTHDLTPAEGWIMQFKIAVGCRSSEKNvqNQVHVQYSTDFGVSWTYLVPQCLPAdpKCSGTVSQ 2810
Cdd:cd10037    19 SHGGHNRnvwavdfFHLLPVLPSTVTHFAQFSINLGCGSHQPG--NSVSLEFSTNHGRSWSLLHTECLPE--LCAGPHLP 94

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 212549597 2811 PSVFFPA---KGWKRVTYTLPDSLIGNPVRFRFYQKYSDM--QWAIDNFYIG 2857
Cdd:cd10037    95 HSTVYSSdnySGWNRITIPLPNAALTSATRFRWRQTGSVVgsMWAIDNVYIG 146

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 74.45 E-value: 7.73e-15

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  436 IVGAVIGTECGTIESGASLVFLKDGERRVCTPYMDTTGYGNLRFHFVMG-----GMCSPGESHENDVLLYAQIDGRKDRI 510
Cdd:cd10045    22 IRGGEVGFGCGVLASGKALVFNGDGRRQLITAPLDSTQSRYLQFTLRLGsksvlGTCPPPDRPGEGVLLHYSCDNGITWK 101

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 212549597  511 VMDTLAYSSYKAPSLVSSVISPDLQTPATKFCLKQNNHRGHNLNVWAVD 559
Cdd:cd10045   102 LLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQPYHSGQNQDVWALD 150

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 74.56 E-value: 1.08e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2524 DTFN-RAPSSHNWLTVNGGKLSSVCGAVASGMALHFSGGCSRLLVSVDLNLTNAEFVQFYFMYGClIIPHSRNQGVLLEY 2602
Cdd:cd10040     4 DKFDgSVDLQANWYRIQGGQVDIDCLSMDTALMFTENIGKPRYAETWDFHVSASTFLQFELSMGC-SKPYSNSHSVQLQY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2603 SVNGGINWFLLME---------IFYDQ---YSKPGFVN-----ILLPASAKTVGTRFRWWQPkHDGLDQNDWAIDNVLIS 2665
Cdd:cd10040    83 SLNNGRDWHLVTEecvppaigcLHYTEssvYSSERFQNwkritVYLPPATISPRTRFRWIQP-NYAPGADSWAIDNVVLA 161

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 74.47 E-value: 1.13e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2172 FLKDDFEGQL-ESDRFLLVSGGKTSRKCGILSSGNNLFFNE-EGLRMLVTRDLDLSLARFVQFFMRLGCGKAVPdpRSQP 2249
Cdd:cd10039     1 YEKPAFDYPLnQMSVWLMLSNEGMGKNESCSPTPSAMVFGKsDGDRFAVTRDLTLKPGYVLQFKVNIGCTSEFS--SFAP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2250 VLLQFSLDGGLSWSVLQE--FHFSNSS----------------NVGRY-----VALEIPLKARSPSTRLRWWQPSENGHF 2306
Cdd:cd10039    79 VLLQYSHDAGLTWSLVREgcYPASPGSkgcegssrelreptvyHTGDYedwtrITIPIPRSLAASKTRFRWIQESSSLKN 158

                         170
                  ....*....|..
gi 212549597 2307 YSPWVIDQILIG 2318
Cdd:cd10039   159 APPFGLDGVYIS 170

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 74.18 E-value: 1.64e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2727 CDSPDGVMICGSHDGREVYTVTHDLTPAEGWIMQFKIAVGCRSSEKNvQNQVHVQYSTDFGVSWTYLVPQCLPADPKCSg 2806
Cdd:cd10040    28 CLSMDTALMFTENIGKPRYAETWDFHVSASTFLQFELSMGCSKPYSN-SHSVQLQYSLNNGRDWHLVTEECVPPAIGCL- 105

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 212549597 2807 TVSQPSVFFPAK--GWKRVTYTLPDSLIGNPVRFRFYQKY----SDMqWAIDNFYIGPGCLDNCNG 2866
Cdd:cd10040   106 HYTESSVYSSERfqNWKRITVYLPPATISPRTRFRWIQPNyapgADS-WAIDNVVLASGCPWMCSG 170

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 73.17 E-value: 2.31e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1075 DFEGLNGWETDWLEVVGGEIvkpEQGCGiiSSGSSMYF--YKDGRRQLVSLDMDTTWVDFIQFYIQIGgettsCNKPDSR 1152
Cdd:cd08525     5 TFDTLPDSNENWFFYPGGVV---KNDCG--STDSALVFteNIGGERYAVTRDLTVNEGYMLQFKINVG-----CSSTFSS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1153 EEGVLLQYSNNGGINWHLLAE-----------------MYFSDFIKSKFVYLELPNAARTPCTRFRWWQPvFSGEGYDQW 1215
Cdd:cd08525    75 SNSVMLEYSTDAGLSWHLVQEeclpsspgcselhpssvYESSTFNGWKRITIPLPNATLSSATRFRWIQY-GYTSGVQTW 153


                  ....*..
gi 212549597 1216 AIDDVII 1222
Cdd:cd08525   154 AIDNVYI 160

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 73.67 E-value: 2.59e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1611 QDKFDgSVDLHANWYRIQGGQVDVDCLSM-------DTALLFNENIGKPRYAETWDFHVMPSSSLQFNLNMGCSKQLSNS 1683
Cdd:cd10041     3 LDTFD-FGPNESNWLFYPGGNTGLYCPYQskgapeeDSAMVFVSSELGEHSITTRDLDVNENTIIQFEINVGCTTESSSA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1684 HVVQLQFSVNNGRDWQQVTEECIPPSIGCLHYTE----SSVYSSERFQTSKRITVYLPSATVSPRTRFRWIQ--YNYGSG 1757
Cdd:cd10041    82 DPVRLEFSRDFGATWHLLLPLCYGSSSISSLCSTelhpSSVYYTGTTQGWRREVILFGKLHLCGSVRFRWYQgfHPAGSQ 161


                  ....*....
gi 212549597 1758 ADAWAIDNV 1766
Cdd:cd10041   162 PVTWAIDNV 170

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 72.93 E-value: 2.99e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  215 QELNPNIWLQCRNCEVGEQCGVIMHSGAVTFCDPyGPRELISVQMNTTTASVLQFSIGSGS------C-RFSYSDPGIVV 287
Cdd:cd10047     9 EGKLSPLWYKITGGQVGTGCGVIKDGKSLYFNGP-GKREARTVPLDTTNIRLVQFYIQIGSklngetClRPRSRNEGIIV 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 212549597  288 SYTKNNSSSWVPLERISAPSNVSTIIHIIYLPPEVKGDSVKFRWRQEnmQAGDvYEACWALDNILI 353
Cdd:cd10047    88 QYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQP--QHGK-PSAQWALDDVLI 150

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 71.86 E-value: 6.68e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2709 TTVNKHWLFHDDCSIERFCDSpDGVMICGSHDGREVYTVTHDLTPAEGWIMQFKIAVGCRSSEKNVQnqVHVQYSTDFGV 2788
Cdd:cd10042     8 TLDSRKWLLHPGGTKMPVCGS-TGDALVFIEKASTRYVVTTDIMVNEDSFLQIDFAASCSVTDSCYA--IELEYSVDLGL 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 212549597 2789 SWTYLVPQCLPADPKCSG-TVSQPSVFFPAKGWKRVTYTLPDSLIGNPVRFRFYQKYS-DMQ--WAIDNFYIG 2857
Cdd:cd10042    85 SWHPLLRDCLPTNVECSSyHLQRILVSDTFNKWTRVTLPLPHYTRSQATRFRWHQPAPfDKQqtWAIDNVYIG 157

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 71.86 E-value: 8.64e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  727 HNFYSIRGAEVSFGCgvLASGKALIFNKDGRRQLITAFLD--SSQSRFLQFTLRIGsksvlstCKAPDKPGEGVLLHYSH 804
Cdd:cd10040    14 ANWYRIQGGQVDIDC--LSMDTALMFTENIGKPRYAETWDfhVSASTFLQFELSMG-------CSKPYSNSHSVQLQYSL 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212549597  805 DNGITWKLM-----------EHYSYLS-YHEPRI-----ISVELPEDAKQFGIQFRWWQPyHSGQGEDVWAIDEIIMTS 866
Cdd:cd10040    85 NNGRDWHLVteecvppaigcLHYTESSvYSSERFqnwkrITVYLPPATISPRTRFRWIQP-NYAPGADSWAIDNVVLAS 162

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 70.99 E-value: 1.30e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  226 RNCEVGEQCGVIMHSGAVTFcDPYGPRELISVQMNTTTASVLQFS--IGS----GSCRF-SYSDPGIVVSYTKNNSSSWV 298
Cdd:cd10045    23 RGGEVGFGCGVLASGKALVF-NGDGRRQLITAPLDSTQSRYLQFTlrLGSksvlGTCPPpDRPGEGVLLHYSCDNGITWK 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 212549597  299 PLERISAPSNVSTIIHIIYLPPEVKGDSVKFRWRQEnmQAGDVYEACWALDNILI 353
Cdd:cd10045   102 LLEHYSYDNYHEPRIVSVELPEDARNFGVQFRWWQP--YHSGQNQDVWALDEISM 154

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 70.19 E-value: 2.20e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1466 WYKITGGQVGTGCGVLSDGKSLYLNGP-GKREARTAALDTTNTRLIQFYIQIGntnggsTCgKPKARNEGVVVQY-TNDN 1543
Cdd:cd10036    18 WSECCGCNVGEQCGVIMHGNALTFCEPyGPRELITVPLNTTTASVLQFAIGSG------SC-RFSYSDPSIIVSYaVNNT 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1544 GISWNLLRELDFMSYLEPQIISIELPRNAKTSGTAFRWWQ--PQHGKQ-SAQWALDDVLI 1600
Cdd:cd10036    91 SSDWITLEKIRAPSNGSTIIHIIPLPTDAKQDNVSFRFRQeaPNAGEVyESCWALDNVLI 150

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 69.17 E-value: 8.83e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1076 FEGLNGWETDWLEVVGGEIvkpEQGCgiISSGSSMYFYKDGRRQLV--SLDMDTTWVDFIQFYIQIGgettsCNKPDSRE 1153
Cdd:cd10040     6 FDGSVDLQANWYRIQGGQV---DIDC--LSMDTALMFTENIGKPRYaeTWDFHVSASTFLQFELSMG-----CSKPYSNS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1154 EGVLLQYSNNGGINWHLLAE----------------MYFSD-FIKSKFVYLELPNAARTPCTRFRWWQPVFsGEGYDQWA 1216
Cdd:cd10040    76 HSVQLQYSLNNGRDWHLVTEecvppaigclhytessVYSSErFQNWKRITVYLPPATISPRTRFRWIQPNY-APGADSWA 154


                  ....*...
gi 212549597 1217 IDDVIILS 1224
Cdd:cd10040   155 IDNVVLAS 162

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 68.42 E-value: 1.46e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1650 GKPRYAETWDFHVMPSSSLQFNLNMGCSKQLSNSH-VVQLQFSVNNGRDWQQVTEECIPPSIGCL-HYTESSVYSSerFQ 1727
Cdd:cd10043    55 GREVSAVTHDLTPTEGWILQFKISVGCKSSEKSAQqPVHVQYSTDFGVSWSYVTPQCLPSDPKCGgSVTQPSVFFP--SK 132

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 212549597 1728 TSKRITVYLPSATVSPRTRFRWIQYnygSGADAWAIDNVVL 1768
Cdd:cd10043   133 GWRRVTIPLPDKLVGRPIRFRFYQK---ASDMQWALDNFYI 170

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 67.63 E-value: 2.56e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1455 FDRFEGK--LSQQWYKITGGQVGTGCGVLSDGKSLYLNGPGKREARTAALDTTNTRLIQFYIQIGntnggstCGKPKARN 1532
Cdd:cd10040     3 QDKFDGSvdLQANWYRIQGGQVDIDCLSMDTALMFTENIGKPRYAETWDFHVSASTFLQFELSMG-------CSKPYSNS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1533 EGVVVQYTNDNGISWNLLRE------LDFMSYLEPQI-----------ISIELPRNAKTSGTAFRWWQPQHGKQSAQWAL 1595
Cdd:cd10040    76 HSVQLQYSLNNGRDWHLVTEecvppaIGCLHYTESSVysserfqnwkrITVYLPPATISPRTRFRWIQPNYAPGADSWAI 155


                  ....*.
gi 212549597 1596 DDVLIG 1601
Cdd:cd10040   156 DNVVLA 161

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 67.39 E-value: 2.95e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3271 YIKDNFESEKVTEINWENIQGGVIGNGCGqlspyAHGDSLYFNGCQI--RQAITKPLDLTRASKIMFVLQIGSIAQTDSC 3348
Cdd:cd08525     1 VLLDTFDTLPDSNENWFFYPGGVVKNDCG-----STDSALVFTENIGgeRYAVTRDLTVNEGYMLQFKINVGCSSTFSSS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3349 NtnlsdtntvdkAVLLQYSVNNGITWQVIAQ-----------------HQPKDFIQAQRVSYNIPLEARMKGVLLRWWQP 3411
Cdd:cd08525    76 N-----------SVMLEYSTDAGLSWHLVQEeclpsspgcselhpssvYESSTFNGWKRITIPLPNATLSSATRFRWIQY 144

                         170
                  ....*....|....*
gi 212549597 3412 RHnGIGHDQWALDHV 3426
Cdd:cd08525   145 GY-TSGVQTWAIDNV 158

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 66.42 E-value: 3.76e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2024 IIQFEINVGCTSdSSSADPVKLEFSRDFGATWHLL----LP-LCysssshisslcSTEHHPSSTYYAGTT-QGWRREVIN 2097
Cdd:cd10037    46 FAQFSINLGCGS-HQPGNSVSLEFSTNHGRSWSLLhtecLPeLC-----------AGPHLPHSTVYSSDNySGWNRITIP 113

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 212549597 2098 FGKLRLCGSIRFRWYQGFYPITMQpvtWAIDNIYIG 2133
Cdd:cd10037   114 LPNAALTSATRFRWRQTGSVVGSM---WAIDNVYIG 146

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 65.96 E-value: 6.18e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3273 KDNFESEKVTEIN---WENIQGGVIGNGCGQLSpyaHGDSLYFngCQI---RQAITKPLDLTRASKIMFVLQIGSIaqTD 3346
Cdd:cd10036     2 RDDFDSYPLLELNnniWSECCGCNVGEQCGVIM---HGNALTF--CEPygpRELITVPLNTTTASVLQFAIGSGSC--RF 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3347 SCNTNlsdtntvdkAVLLQYSVNNG-ITWQVIAQ-HQPKDfiqAQRVSYNIPL--EARMKGVLLRWWQPRHNGIGHDQ-- 3420
Cdd:cd10036    75 SYSDP---------SIIVSYAVNNTsSDWITLEKiRAPSN---GSTIIHIIPLptDAKQDNVSFRFRQEAPNAGEVYEsc 142


                  ....*....
gi 212549597 3421 WALDHVEVV 3429
Cdd:cd10036   143 WALDNVLII 151

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 65.69 E-value: 8.58e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  903 LCFTGDSKqasspRYVETQSMQIGASYMIQFSLVMGCGERYTPHMDNQVMLEYSTNHGLTWHLVqqeclpsmpscQEFTS 982
Cdd:cd10049    39 LFFNEDGL-----RMLVTRDLDLSMARFVQFFMRLGCGKGVPDPRSQPVLLQYSLNGGLTWSLL-----------QEFLF 102

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 212549597  983 SSiyhSSEFTHWrrITLPLPQKTWSGATRFRWSQ-----RYYtsdDEWALDNIYIG 1033
Cdd:cd10049   103 SN---SSNVGRY--VALEIPLKARSPSTRLRWWQpsengHFY---SPWVIDQILIG 150

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 65.70 E-value: 8.98e-12

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2173 LKDDFEgQLESDRFLLVSGGKTSRKCGilSSGNNLFFNE-EGLRMLVTRDLDLSLARFVQFFMRLGCgkAVPDpRSQPVL 2251
Cdd:cd10042     2 LEDDFS-TLDSRKWLLHPGGTKMPVCG--STGDALVFIEkASTRYVVTTDIMVNEDSFLQIDFAASC--SVTD-SCYAIE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2252 LQFSLDGGLSWS----------------VLQEFHFSNSSNVGRYVALEIPLKARSPSTRLRWWQPS--ENGHfysPWVID 2313
Cdd:cd10042    76 LEYSVDLGLSWHpllrdclptnvecssyHLQRILVSDTFNKWTRVTLPLPHYTRSQATRFRWHQPApfDKQQ---TWAID 152


                  ....*
gi 212549597 2314 QILIG 2318
Cdd:cd10042   153 NVYIG 157

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 64.80 E-value: 1.78e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1074 SDFEGLNGWetdWLEVVGGEIvkpEQGCGIISSGSSMYFYK-DGRRQLVSLDMDTTWVDFIQFYIQIGgettSCnKPDSR 1152
Cdd:cd10036     9 PLLELNNNI---WSECCGCNV---GEQCGVIMHGNALTFCEpYGPRELITVPLNTTTASVLQFAIGSG----SC-RFSYS 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 212549597 1153 EEGVLLQYS-NNGGINWHLLAEMYFSDFIKSKFVYLELPNAARTPCTRFRWWQPVF-SGEGY-DQWAIDDVIIL 1223
Cdd:cd10036    78 DPSIIVSYAvNNTSSDWITLEKIRAPSNGSTIIHIIPLPTDAKQDNVSFRFRQEAPnAGEVYeSCWALDNVLII 151

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 62.83 E-value: 6.04e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  425 EEFENLPAG--W-EIVGAVIGTECGTIESGASLVFLKD-GERRVCTPYMDTTGYGNLRFHFvMGGMCSPGESHENDVLLY 500
Cdd:cd08524     3 DDFDGYPSPdnWlLCPGGKTGTVCGALSSGNALVFNEPyGPRELVTTDLNTNEASFLQFYI-GSGCSTPSYSNQPVLLEY 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 212549597  501 AqIDGRKDRIVMDTLAYSSYKAPSLVSSVISPDLQTPATKFCLKQNNHRGHNLNVWAVDFV 561
Cdd:cd08524    82 S-VDNGASWHLLEEIRADSFSKWRIIILYLPEDAKSGATRFRWWQPNHRGVYQATWAIDNV 141

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 62.94 E-value: 8.11e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  902 TLCFTGDSKqasspRYVETQSMQIGASYMIQFSLVMGCGER---YTPHMDNQVMLEYSTNHGLTWHLVQQeclpsmpscq 978
Cdd:cd10046    42 SLYFNKDGL-----RQLVSWDLDTTWVDFIQFYIQIGGGSAscnYPDSREEGVLLQYSNNGGISWKLLAE---------- 106

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 212549597  979 eftsssIYHSSeFTHWRRITLPLPQKTWSGATRFRWSQRYYTSD--DEWALDNIYIG 1033
Cdd:cd10046   107 ------MYFSD-FSKPRFVYLELPTAAKTPCTRFRWWQPVFSGEgyDQWALDDIIIL 156

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 62.49 E-value: 1.21e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2522 LKDTFNRAPSSHN----WLTVNGGKLSSVCGAVASGMALHFSGGC-SRLLVSVDLNLTNAEFVQFYFMYGClIIPHSRNQ 2596
Cdd:cd10036     1 LRDDFDSYPLLELnnniWSECCGCNVGEQCGVIMHGNALTFCEPYgPRELITVPLNTTTASVLQFAIGSGS-CRFSYSDP 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 212549597 2597 GVLLEYSVNGG-INWFLLMEIFYDQYSKPGFVNILLPASAKTVGTRFRWWQ--PKHDGLDQNDWAIDNVLI 2664
Cdd:cd10036    80 SIIVSYAVNNTsSDWITLEKIRAPSNGSTIIHIIPLPTDAKQDNVSFRFRQeaPNAGEVYESCWALDNVLI 150

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 62.10 E-value: 1.36e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  720 SSRLSSYHNFYS-IRGAEVSFGCGVLASGKALIF-NKDGRRQLITAFLDSSQSRFLQFTLRIGS-KSVLSTCKapdkpge 796
Cdd:cd10036     8 YPLLELNNNIWSeCCGCNVGEQCGVIMHGNALTFcEPYGPRELITVPLNTTTASVLQFAIGSGScRFSYSDPS------- 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 212549597  797 gVLLHYSHDNG-ITWKLMEHYSYLSYHEPRIISVELPEDAKQFGIQFRWWQPY-HSGQG-EDVWAIDEIIMT 865
Cdd:cd10036    81 -IIVSYAVNNTsSDWITLEKIRAPSNGSTIIHIIPLPTDAKQDNVSFRFRQEApNAGEVyESCWALDNVLII 151

Reeler domain;

Pssm-ID: 460411 Cd Length: 130 Bit Score: 60.45 E-value: 2.90e-10

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597    67 NPGYYVPGQEYHVTISTSTF---FDGLLVtglytstsvQA-SQSIGGSKAFG-FGIMSDRQFGTQFMCSVVASHVSH--- 138
Cdd:pfam02014   25 SSTSYRPGETITVTLSGASGgpsFKGFLL---------QArDADSGDPDPVGsFSLPDDADTKFLLDCSGKGNAVTHsnt 95

                           90       100
                   ....*....|....*....|....*
gi 212549597   139 LPTTNLSFVWIAPPAGTGCVNFMAT 163
Cdd:pfam02014   96 NKKSSVTVTWTAPASGSGCVVFRAT 120

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 61.76 E-value: 3.15e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2895 FLKERFDSEEIRSDFWLSVDGGKTCTDCGVLAEDMALYFGAS-AVRQTITQDLDLRGAKFVQYWARIGSENMTSCRKPVc 2973
Cdd:cd10039     1 YEKPAFDYPLNQMSVWLMLSNEGMGKNESCSPTPSAMVFGKSdGDRFAVTRDLTLKPGYVLQFKVNIGCTSEFSSFAPV- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2974 rkegvLLDYSIDGGITWTLLHEMDY-------------------QKYMSVRYD-----YILLPENAQTNTTRLRWWQpfT 3029
Cdd:cd10039    80 -----LLQYSHDAGLTWSLVREGCYpaspgskgcegssrelrepTVYHTGDYEdwtriTIPIPRSLAASKTRFRWIQ--E 152

                         170       180
                  ....*....|....*....|...
gi 212549597 3030 VSNGLVVLgqersQWALDNILIG 3052
Cdd:cd10039   153 SSSLKNAP-----PFGLDGVYIS 170

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 60.96 E-value: 4.05e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1610 FQDKFDGSVDLHANWYRIQGGQVDVDCLSMD-----TALLFNeNIGKpRYAETWDFHVMPSSSLQFNLNMG-------CS 1677
Cdd:cd10052     4 IKDNFESGSVSELKWSLIQGGGIGSGCGQLAphahgDSLYFN-GCGI-RQAVTVELDLTRASKIMFVLQIGsrsqtdsCN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1678 KQLSNSHV----VQLQFSVNNGRDWQQVTEEciPPSigclHYTEssvysserfqtSKRITVYLPSATVSPRTRFRWIQYN 1753
Cdd:cd10052    82 INLSSPRAvdkaVLLQYSVNNGITWYLIAQH--QPK----DFMR-----------AQRVSYNLPLEARTKGVVLRWWQPR 144

                         170
                  ....*....|....
gi 212549597 1754 Y-GSGADAWAIDNV 1766
Cdd:cd10052   145 HdGTGHDQWALDNV 158

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 60.56 E-value: 7.04e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1958 PAILLDTFDFGP-NEENWFFYPGGNIALYCpytskGSPEEDSAMVFVSNevGEHSITTRDLDVDENTIIQFEINVGCTSD 2036
Cdd:cd10051     1 KTFLKERFDSEEiSSDQWLSLEGGVTCTDC-----GVLAEGDALYFGGS--GARQAVTQDLDLRGAKFVQYWARIGSENN 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2037 SSSA-------DPVKLEFSRDFGATWHLLLPLCYsssshisslcstEHHPSSTYyagttqgwrrEVINFGKLRLCGSIRF 2109
Cdd:cd10051    74 MTLClrptcrkEGVLLQYSTDGGISWTLLHELDY------------QKYISVRY----------DYITLPENARTNSTRL 131

                         170       180       190
                  ....*....|....*....|....*....|.
gi 212549597 2110 RWYQGFyPITMQPVT-------WAIDNIYIG 2133
Cdd:cd10051   132 RWWQPF-TISNGLVVsgteraqWALDNILIG 161

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 59.08 E-value: 1.58e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  210 DSYKLQELNPNiWLQCRNCEVGEQCGVIMHSGAVTF---CDpygpRELISVQMNTTTASVLQFSIGSGsCRF--SYSDPG 284
Cdd:cd10050     7 DTFNRAPSSSN-WLTVVGGKLSTVCGAVASGTALHFsggCS----RQLVTVDLNLTNAEFVQFYFMYG-CLIppSNRNQG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212549597  285 IVVSYTKNNSSSWVPLERISAPSNVSTIIHIIYLPPEVKGDSVKFRWRQENMQAGDvyEACWALDNILI 353
Cdd:cd10050    81 VLLEYSVNGGITWNLLMEIFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLD--QNDWAIDNVLI 147

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 59.42 E-value: 1.63e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  885 SLGFYLGNVQPYCeHDWTLCFTGDSKqasspRYVETQSMQIGASYMIQFSLVMG-------CGERYT-PH-MDNQVMLEY 955
Cdd:cd10052    25 GIGSGCGQLAPHA-HGDSLYFNGCGI-----RQAVTVELDLTRASKIMFVLQIGsrsqtdsCNINLSsPRaVDKAVLLQY 98

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 212549597  956 STNHGLTWHLVQQeclpsmpscqeftsssiYHSSEFTHWRRITLPLPQKTWSGATRFRWSQRYY--TSDDEWALDNI 1030
Cdd:cd10052    99 SVNNGITWYLIAQ-----------------HQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHdgTGHDQWALDNV 158

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 59.08 E-value: 1.76e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  931 IQFSLVMGCgeRYTPHMDNQ-VMLEYSTNHGLTWHLVQQeclpsmpscqeftsssIYHsSEFTHWRRITLPLPQKTWSGA 1009
Cdd:cd10050    62 VQFYFMYGC--LIPPSNRNQgVLLEYSVNGGITWNLLME----------------IFY-DQYSKPGFVNILLPPEARGVG 122

                          90       100
                  ....*....|....*....|....*.
gi 212549597 1010 TRFRWSQRYYTSDD--EWALDNIYIG 1033
Cdd:cd10050   123 TRFRWWQPSHDGLDqnDWAIDNVLIG 148

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 58.25 E-value: 2.82e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2173 LKDDFE----GQLESDRFLLVSGGKTSRKCGILSSGNNLFFNE-EGLRMLVTRDLDLSLARFVQFfmRLGCGKAVPDPRS 2247
Cdd:cd10036     1 LRDDFDsyplLELNNNIWSECCGCNVGEQCGVIMHGNALTFCEpYGPRELITVPLNTTTASVLQF--AIGSGSCRFSYSD 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 212549597 2248 QPVLLQFSLDGG-LSWSVLQEFHF-SNSSNVGRyvALEIPLKARSPSTRLRWWQPSENG--HFYSPWVIDQILI 2317
Cdd:cd10036    79 PSIIVSYAVNNTsSDWITLEKIRApSNGSTIIH--IIPLPTDAKQDNVSFRFRQEAPNAgeVYESCWALDNVLI 150

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 59.06 E-value: 2.84e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2535 WLTVNGGKLSSVCGAVASGMALHF--SGGcSRLLVSVDLNLTNAEFVQFYFMYGCLIiPHSRNQGVLLEYSVNGGINWFL 2612
Cdd:cd10039    16 WLMLSNEGMGKNESCSPTPSAMVFgkSDG-DRFAVTRDLTLKPGYVLQFKVNIGCTS-EFSSFAPVLLQYSHDAGLTWSL 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 212549597 2613 LMEIFY------------------------DQYSKPGFVNILLPASAKTVGTRFRWWQPKHDGLDQNDWAIDNVLIS 2665
Cdd:cd10039    94 VREGCYpaspgskgcegssrelreptvyhtGDYEDWTRITIPIPRSLAASKTRFRWIQESSSLKNAPPFGLDGVYIS 170

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 58.25 E-value: 3.69e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2330 DFSSLDNKKWLLHPGGTKMSVCG--SSGDALVFiEKASTRYVVTTDIVVNEDSFLQI-------DFAASC-SVTDSCYAI 2399
Cdd:cd10051     9 DSEEISSDQWLSLEGGVTCTDCGvlAEGDALYF-GGSGARQAVTQDLDLRGAKFVQYwarigseNNMTLClRPTCRKEGV 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2400 ELEYSVDLGLSWNpVLKDClptnvecsNYQlqralvsdTFNKWTRFTLPLPPYTRSQATRFRWNQP--------SPFDKQ 2471
Cdd:cd10051    88 LLQYSTDGGISWT-LLHEL--------DYQ--------KYISVRYDYITLPENARTNSTRLRWWQPftisnglvVSGTER 150

                         170
                  ....*....|.
gi 212549597 2472 QTWAIDNVYIG 2482
Cdd:cd10051   151 AQWALDNILIG 161

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 58.25 E-value: 4.35e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  205 LRDDFDSyklQELNPNIWLQCRNCEVGEQCGVIMHSGAVTFCDPyGPRELISVQMNTTTASVLQF--SIGS----GSCRF 278
Cdd:cd10051     4 LKERFDS---EEISSDQWLSLEGGVTCTDCGVLAEGDALYFGGS-GARQAVTQDLDLRGAKFVQYwaRIGSennmTLCLR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  279 SYS-DPGIVVSYTKNNSSSWVPLERISAPSNVSTIIHIIYLPPEVKGDSVKFRWRQ-----ENMQAGDVYEACWALDNIL 352
Cdd:cd10051    80 PTCrKEGVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQpftisNGLVVSGTERAQWALDNIL 159


                  .
gi 212549597  353 I 353
Cdd:cd10051   160 I 160

N-terminal subrepeat in the tandem repeat unit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197342 Cd Length: 161 Bit Score: 57.76 E-value: 5.80e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  205 LRDDFDSykLQELNPNiWLQCRNCEVGEQCGviMHSGAVTFC-DPYGPRELISVQMNTTTASVLQFSIGSGsCRFSYSDP 283
Cdd:cd08525     2 LLDTFDT--LPDSNEN-WFFYPGGVVKNDCG--STDSALVFTeNIGGERYAVTRDLTVNEGYMLQFKINVG-CSSTFSSS 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  284 GIV-VSYTKNNSSSWVPLERISAPSNVSTIIH-----------------IIYLPPEVKGDSVKFRWRQENMQAGDVyeaC 345
Cdd:cd08525    76 NSVmLEYSTDAGLSWHLVQEECLPSSPGCSELhpssvyesstfngwkriTIPLPNATLSSATRFRWIQYGYTSGVQ---T 152


                  ....*...
gi 212549597  346 WALDNILI 353
Cdd:cd08525   153 WAIDNVYI 160

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 57.50 E-value: 7.40e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  205 LRDDFDSYKLQELNpniWLQCRNCEVGEQCGVIM---HSGAVTFcDPYGPRELISVQMNTTTASVLQF--SIGS----GS 275
Cdd:cd10052     4 IKDNFESGSVSELK---WSLIQGGGIGSGCGQLAphaHGDSLYF-NGCGIRQAVTVELDLTRASKIMFvlQIGSrsqtDS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  276 CRFSYSDP-----GIVVSYTKNNSSSWvPLERISAPSNVSTIIHIIY-LPPEVKGDSVKFRWRQEnmQAGDVYEACWALD 349
Cdd:cd10052    80 CNINLSSPravdkAVLLQYSVNNGITW-YLIAQHQPKDFMRAQRVSYnLPLEARTKGVVLRWWQP--RHDGTGHDQWALD 156


                  ....*
gi 212549597  350 NILII 354
Cdd:cd10052   157 NVEVV 161

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 56.73 E-value: 1.23e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2327 IEDDFSSL---DNKKWLLHPGGTKMSVCG--SSGDALVFiEKASTRYVVTTDIVVNEDSFLQIDF-AASCSVTDSCYA-- 2398
Cdd:cd10045     4 LSESFNSSrlsSYHNFSSIRGGEVGFGCGvlASGKALVF-NGDGRRQLITAPLDSTQSRYLQFTLrLGSKSVLGTCPPpd 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2399 -----IELEYSVDLGLSWNpvlkdcLPTNVECSNYQLQRaLVSdtfnkwtrftLPLPPYTRSQATRFRWNQP-SPFDKQQ 2472
Cdd:cd10045    83 rpgegVLLHYSCDNGITWK------LLEHYSYDNYHEPR-IVS----------VELPEDARNFGVQFRWWQPyHSGQNQD 145


                  ....*....
gi 212549597 2473 TWAIDNVYI 2481
Cdd:cd10045   146 VWALDEISM 154

Tandem repeat subunit of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the subrepeats, which directly contact each other in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197341 [Multi-domain] Cd Length: 144 Bit Score: 56.28 E-value: 1.36e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3123 IQFKIVVGC--DVSSCvdlHSVMLEYTKDARTdSWQLVQTqclpsssnsvgcspflfheasiYNSVNSSVWKRVTLQLPD 3200
Cdd:cd08524    59 LQFYIGSGCstPSYSN---QPVLLEYSVDNGA-SWHLLEE----------------------IRADSFSKWRIIILYLPE 112

                          90       100       110
                  ....*....|....*....|....*....|..
gi 212549597 3201 YVSSSATQFRWIQKGDETEKQS-WAVDHVYIG 3231
Cdd:cd08524   113 DAKSGATRFRWWQPNHRGVYQAtWAIDNVLIG 144

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 56.04 E-value: 1.74e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1611 QDKFDGSV--DLHANWYRIQGGQVDVDCLSMDTALLFNENigKPRYAETWDFHVMPSSSLQFNLNMGCSKQLSNSHVVQL 1688
Cdd:cd10048     6 KDDFNGNLrpDLWPEVYGAERGNLNGETIKSGTALIFKGE--GLRMLVSRDLDCTHTLYIQFSFKFITKGTPERSHSVLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1689 QFSVNNGRDWQQVTEECIPPSIGCLHytessvysserfqtskrITVYLPSATVSPRTRFR-WIQYNYGSGADAWAIDNVV 1767
Cdd:cd10048    84 QYSINGGITWHLIDEFYFPTTTDVLF-----------------VNVPLPYTAQTNATRFRlWQPYNSGKKEEVWILDDLV 146


                  .
gi 212549597 1768 L 1768
Cdd:cd10048   147 I 147

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 55.61 E-value: 2.78e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  436 IVGAVIGTECGTIESGASLVFLKDGERRVCTPYMDTTGYGNLRFHFVMGGMCSPgeSHEND-VLLYAQIDGRKDRIVMDT 514
Cdd:cd10050    21 VVGGKLSTVCGAVASGTALHFSGGCSRQLVTVDLNLTNAEFVQFYFMYGCLIPP--SNRNQgVLLEYSVNGGITWNLLME 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 212549597  515 LAYSSYKAPSLVSSVISPDLQTPATKFCLKQNNHRGHNLNVWAVDFV 561
Cdd:cd10050    99 IFYDQYSKPGFVNILLPPEARGVGTRFRWWQPSHDGLDQNDWAIDNV 145

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 55.17 E-value: 4.20e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  912 ASSPRYVETQSMQIGASYMIQFSLVMG----CGERYTPHMDNQ-VMLEYSTNHGLTWHLvqqecLPSMPSCQEFTSSSIY 986
Cdd:cd10051    43 GSGARQAVTQDLDLRGAKFVQYWARIGsennMTLCLRPTCRKEgVLLQYSTDGGISWTL-----LHELDYQKYISVRYDY 117

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 212549597  987 hssefthwrrITLPLPQKTwsGATRFRWSQRYYTSDD---------EWALDNIYIG 1033
Cdd:cd10051   118 ----------ITLPENART--NSTRLRWWQPFTISNGlvvsgteraQWALDNILIG 161

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 55.24 E-value: 4.28e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  563 VLPVLPSTESHMVQFSINLGCGS---HQPG---NSVRLEFSTNHGRSWSLLhseclpelcagshlphSTIYSSDnYSGWN 636
Cdd:cd10046    54 VSWDLDTTWVDFIQFYIQIGGGSascNYPDsreEGVLLQYSNNGGISWKLL----------------AEMYFSD-FSKPR 116

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 212549597  637 RITIPLPNAALTRDTRLRWRQngPVMG----NMWALDNIYIG 674
Cdd:cd10046   117 FVYLELPTAAKTPCTRFRWWQ--PVFSgegyDQWALDDIIIL 156

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 54.90 E-value: 4.49e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1611 QDKFDGSVDLHaNWYRIQGGQVDVDC--LSMDTALLFNENigKPRYAETWDFHVMPSSSLQFNLNMGCSKQLSN--SHVV 1686
Cdd:cd10049     6 KDDFEGQLESD-RFLLMSGGKPSRKCgiLSSGNNLFFNED--GLRMLVTRDLDLSMARFVQFFMRLGCGKGVPDprSQPV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1687 QLQFSVNNGRDWQQVTEECIPPSIGCLHYtessvysserfqtskrITVYLPSATVSPRTRFRWIQYNY-GSGADAWAIDN 1765
Cdd:cd10049    83 LLQYSLNGGLTWSLLQEFLFSNSSNVGRY----------------VALEIPLKARSPSTRLRWWQPSEnGHFYSPWVIDQ 146


                  ...
gi 212549597 1766 VVL 1768
Cdd:cd10049   147 ILI 149

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 54.89 E-value: 5.39e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  931 IQFSLVMGCgeRYTPHMDNQVMLEYSTNHGLTWHLVQQEcLPSMPSCQEFtsssiyhssefthwrrITLPLPQKTWSGAT 1010
Cdd:cd10048    63 IQFSFKFIT--KGTPERSHSVLLQYSINGGITWHLIDEF-YFPTTTDVLF----------------VNVPLPYTAQTNAT 123

                          90       100
                  ....*....|....*....|....*
gi 212549597 1011 RFRWSQRYYTSDDE--WALDNIYIG 1033
Cdd:cd10048   124 RFRLWQPYNSGKKEevWILDDLVID 148

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 54.01 E-value: 8.36e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2896 LKERFDS---EEIRSDFWLSVDGGKTCTDCGVLAEDMALYF-GASAVRQTITQDLDLRGAKFVQYwarigSENMTSCRkP 2971
Cdd:cd10036     1 LRDDFDSyplLELNNNIWSECCGCNVGEQCGVIMHGNALTFcEPYGPRELITVPLNTTTASVLQF-----AIGSGSCR-F 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2972 VCRKEGVLLDYSIDGG-ITWTLLHEMDYQKYMSVRYDYILLPENAQTNTTRLRWWQpfTVSNGLVVLgqeRSQWALDNIL 3050
Cdd:cd10036    75 SYSDPSIIVSYAVNNTsSDWITLEKIRAPSNGSTIIHIIPLPTDAKQDNVSFRFRQ--EAPNAGEVY---ESCWALDNVL 149


                  .
gi 212549597 3051 I 3051
Cdd:cd10036   150 I 150

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 54.01 E-value: 8.77e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2329 DDFSS-----LDNKKWLLHPGGTKMSVCG--SSGDALVFIEKASTRYVVTTDIVVNEDSFLQIDFAA-SCSVTDSCYAIE 2400
Cdd:cd10036     3 DDFDSyplleLNNNIWSECCGCNVGEQCGviMHGNALTFCEPYGPRELITVPLNTTTASVLQFAIGSgSCRFSYSDPSII 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2401 LEYSVDLG-LSWNPVLKDCLPTNVECSNYqlqralvsdtfnkwtrfTLPLPPYTRSQATRFRWNQPSPFDKQQ---TWAI 2476
Cdd:cd10036    83 VSYAVNNTsSDWITLEKIRAPSNGSTIIH-----------------IIPLPTDAKQDNVSFRFRQEAPNAGEVyesCWAL 145


                  ....*
gi 212549597 2477 DNVYI 2481
Cdd:cd10036   146 DNVLI 150

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 53.70 E-value: 1.20e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  234 CGVIMHSGAVTFCDPyGPRELISVQMNTTTASVLQFSI----GSGSCRFSYS-DPGIVVSYTKNNSSSWVPLERISAPSN 308
Cdd:cd10046    34 CGVISSGSSLYFNKD-GLRQLVSWDLDTTWVDFIQFYIqiggGSASCNYPDSrEEGVLLQYSNNGGISWKLLAEMYFSDF 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 212549597  309 VSTIIHIIYLPPEVKGDSVKFRWRQEnMQAGDVYEAcWALDNILI 353
Cdd:cd10046   113 SKPRFVYLELPTAAKTPCTRFRWWQP-VFSGEGYDQ-WALDDIII 155

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 54.06 E-value: 1.39e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  734 GAEVSFGCGvlASGKALIFNK-DGRRQLITAFLDSSQSRFLQFTLRIGSKSVLSTcKAPdkpgegVLLHYSHDNGITWKL 812
Cdd:cd10039    23 GMGKNESCS--PTPSAMVFGKsDGDRFAVTRDLTLKPGYVLQFKVNIGCTSEFSS-FAP------VLLQYSHDAGLTWSL 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 212549597  813 MEHYSY---------------LS---------YHEPRIISVELPEDAKQFGIQFRWWQPYHSGQGEDVWAIDEI 862
Cdd:cd10039    94 VREGCYpaspgskgcegssreLReptvyhtgdYEDWTRITIPIPRSLAASKTRFRWIQESSSLKNAPPFGLDGV 167

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 53.24 E-value: 1.92e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1611 QDKFDGSVDLHANWYRIQGGQVDVDC--LSMDTALLFneniGKP--RYAETWDFHVMPSSSLQFNLNMG-------CSKQ 1679
Cdd:cd10051     5 KERFDSEEISSDQWLSLEGGVTCTDCgvLAEGDALYF----GGSgaRQAVTQDLDLRGAKFVQYWARIGsennmtlCLRP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1680 LSNSHVVQLQFSVNNGRDWQQVTEecippsigcLHYtessvyssERFQTSKRITVYLPSATVSPRTRFRWIQ-------- 1751
Cdd:cd10051    81 TCRKEGVLLQYSTDGGISWTLLHE---------LDY--------QKYISVRYDYITLPENARTNSTRLRWWQpftisngl 143

                         170
                  ....*....|....*
gi 212549597 1752 YNYGSGADAWAIDNV 1766
Cdd:cd10051   144 VVSGTERAQWALDNI 158

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 52.98 E-value: 2.01e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1281 IFGKSDGDRFAVTRDLTLKPGYVLQFKLNVGCTNEFSGM--APVLLQYSHDAGLSWSLVREGCYPASPGIkdcegssrel 1358
Cdd:cd10049    39 LFFNEDGLRMLVTRDLDLSMARFVQFFMRLGCGKGVPDPrsQPVLLQYSLNGGLTWSLLQEFLFSNSSNV---------- 108

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 212549597 1359 geptsyytGDYedwtrITIVIPRSLASSKTRFRWIQESSS 1398
Cdd:cd10049   109 --------GRY-----VALEIPLKARSPSTRLRWWQPSEN 135

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 53.64 E-value: 2.06e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2173 LKDDFEGQLESDRFLLVSGGKTSRKCGILSSG-----NNLFF--NEEGLRMLVTRDLDLSLARFVQFFMRLGCgkAVPDP 2245
Cdd:cd10041     2 LLDTFDFGPNESNWLFYPGGNTGLYCPYQSKGapeedSAMVFvsSELGEHSITTRDLDVNENTIIQFEINVGC--TTESS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2246 RSQPVLLQFSLDGGLSWSVLQEFHFSNSSNVG---------------------RYVALEIPLKARSpSTRLRWWQ----P 2300
Cdd:cd10041    80 SADPVRLEFSRDFGATWHLLLPLCYGSSSISSlcstelhpssvyytgttqgwrREVILFGKLHLCG-SVRFRWYQgfhpA 158

                         170
                  ....*....|....*...
gi 212549597 2301 SENGHfysPWVIDQILIG 2318
Cdd:cd10041   159 GSQPV---TWAIDNVYIG 173

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 53.37 E-value: 2.45e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3274 DNFESEKVTEINWENIQGGVIGNGCgqlspYAHGDSLYFNG--CQIRQAITKPLDLTRASKIMFVLQIGsiaqtdsCNTN 3351
Cdd:cd10040     4 DKFDGSVDLQANWYRIQGGQVDIDC-----LSMDTALMFTEniGKPRYAETWDFHVSASTFLQFELSMG-------CSKP 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3352 LSDTNTVDkavlLQYSVNNGITWQVIAQ-----------------HQPKDFIQAQRVSYNIPLEARMKGVLLRWWQPrHN 3414
Cdd:cd10040    72 YSNSHSVQ----LQYSLNNGRDWHLVTEecvppaigclhytessvYSSERFQNWKRITVYLPPATISPRTRFRWIQP-NY 146

                         170
                  ....*....|..
gi 212549597 3415 GIGHDQWALDHV 3426
Cdd:cd10040   147 APGADSWAIDNV 158

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 52.60 E-value: 3.65e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1075 DFEGLNGweTDWLEVVGGEIVkpeQGCGiiSSGSSMYFY-KDGRRQLVSLDMDTTWVDFIQFYIQIG-GETTSCnkpdsr 1152
Cdd:cd10042     5 DFSTLDS--RKWLLHPGGTKM---PVCG--STGDALVFIeKASTRYVVTTDIMVNEDSFLQIDFAAScSVTDSC------ 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1153 eEGVLLQYSNNGGINWH----------------LLAEMYFSD-FIKSKFVYLELPNAARTPCTRFRWWQPVFSGEGYdQW 1215
Cdd:cd10042    72 -YAIELEYSVDLGLSWHpllrdclptnvecssyHLQRILVSDtFNKWTRVTLPLPHYTRSQATRFRWHQPAPFDKQQ-TW 149


                  ....*..
gi 212549597 1216 AIDDVII 1222
Cdd:cd10042   150 AIDNVYI 156

N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197348 Cd Length: 170 Bit Score: 52.22 E-value: 5.05e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2910 WLSVDGGKTCTDCgvLAEDMALYFGASA--VRQTITQDLDLRGAKFVQYWARIGsenmtsCRKPVCRKEGVLLDYSIDGG 2987
Cdd:cd10040    16 WYRIQGGQVDIDC--LSMDTALMFTENIgkPRYAETWDFHVSASTFLQFELSMG------CSKPYSNSHSVQLQYSLNNG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2988 ITWTLLHE---------MDYQK---YMSVRYD-----YILLPENAQTNTTRLRWWQP-FTVSnglvvlgqeRSQWALDNI 3049
Cdd:cd10040    88 RDWHLVTEecvppaigcLHYTEssvYSSERFQnwkriTVYLPPATISPRTRFRWIQPnYAPG---------ADSWAIDNV 158


                  ...
gi 212549597 3050 LIG 3052
Cdd:cd10040   159 VLA 161

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 51.76 E-value: 6.17e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1958 PAILLDTFDFGPNEENWFFYPGGNIALYCpytskGSPEEDSAMVFVSNevGEHSITTRDLDVDENTIIQFEINVGCTSDS 2037
Cdd:cd10050     2 PTQLKDTFNRAPSSSNWLTVVGGKLSTVC-----GAVASGTALHFSGG--CSRQLVTVDLNLTNAEFVQFYFMYGCLIPP 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2038 SSADP-VKLEFSRDFGATWHLLLPLCYSSSSHISSLCSTehHPSSTYYAGTtqgwrrevinfgklrlcgsiRFRWYQGFY 2116
Cdd:cd10050    75 SNRNQgVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNIL--LPPEARGVGT--------------------RFRWWQPSH 132

                         170
                  ....*....|....*..
gi 212549597 2117 PITMQPvTWAIDNIYIG 2133
Cdd:cd10050   133 DGLDQN-DWAIDNVLIG 148

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 51.40 E-value: 7.46e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1502 LDTTNTRLIQFYIQIGntnggstCGKPKARNEgVVVQYTNDNGISWNLLRE-----------------LDFMSYLEPQII 1564
Cdd:cd10037    39 LPSTVTHFAQFSINLG-------CGSHQPGNS-VSLEFSTNHGRSWSLLHTeclpelcagphlphstvYSSDNYSGWNRI 110

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 212549597 1565 SIELPRNAKTSGTAFRWWQPqHGKQSAQWALDDVLIG 1601
Cdd:cd10037   111 TIPLPNAALTSATRFRWRQT-GSVVGSMWAIDNVYIG 146

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 51.32 E-value: 9.34e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  586 HQPGNSVRLEFSTNHGRSWSLLHseclpELcagSHLPHSTiySSDNYsgwnritIPLPNAALTRDTRLRWRQ-----NGP 660
Cdd:cd10051    81 TCRKEGVLLQYSTDGGISWTLLH-----EL---DYQKYIS--VRYDY-------ITLPENARTNSTRLRWWQpftisNGL 143

                          90
                  ....*....|....*...
gi 212549597  661 VMGNM----WALDNIYIG 674
Cdd:cd10051   144 VVSGTeraqWALDNILIG 161

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 51.01 E-value: 1.03e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2229 FVQFFMRLGCGKAVPdprSQPVLLQFSLDGGLSWSVLQE----------------FHFSNSSNVGRYVALEIPLKARSPS 2292
Cdd:cd10037    46 FAQFSINLGCGSHQP---GNSVSLEFSTNHGRSWSLLHTeclpelcagphlphstVYSSDNYSGWNRITIPLPNAALTSA 122

                          90       100
                  ....*....|....*....|....*.
gi 212549597 2293 TRLRWWQPSENGHfySPWVIDQILIG 2318
Cdd:cd10037   123 TRFRWRQTGSVVG--SMWAIDNVYIG 146

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 51.46 E-value: 1.08e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2552 SGMALHFSGgcSRLLVSVDLNLTNAEFVQFYFMYGC--LIIPHSRNQgVLLEYSVNGGINWFLLME-------------- 2615
Cdd:cd10038    37 TGDSKHASS--ARYVETQSMQIGASYMIQFSLVMGCgqQYTPHMDNQ-VKLEYSTNHGLTWHLVQEeclpgmpscqefts 113

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 212549597 2616 --IFY-DQYSKPGFVNILLPASAKTVGTRFRWWQPKHDglDQNDWAIDNVLI 2664
Cdd:cd10038   114 gsIYHsSEFTEWRRITLPLPQKTWSSATRFRWSQSYYT--DQDEWALDNIYI 163

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 50.65 E-value: 1.46e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  204 LLRDDFDSyklqELNPNIWLQCRNCEVGEQCGVIMHSGAVTFCDPYGPRELISVQMNTTTASVLQFS---IGSGSCRFSY 280
Cdd:cd10048     4 VLKDDFNG----NLRPDLWPEVYGAERGNLNGETIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSfkfITKGTPERSH 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 212549597  281 SdpgIVVSYTKNNSSSWVPLERISAPSNVSTIIHIIYLPPEVKGDSVKFRWRQEnmQAGDVYEACWALDNILI 353
Cdd:cd10048    80 S---VLLQYSINGGITWHLIDEFYFPTTTDVLFVNVPLPYTAQTNATRFRLWQP--YNSGKKEEVWILDDLVI 147

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 51.07 E-value: 1.53e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1472 GQVGTGCG----VLSDGKSLYLNGPgkREARTAALDTTNTRLIQFYIQIGntnggstCGK---PKARNEgVVVQYTNDNG 1544
Cdd:cd10038    22 GNVQPYCNhdwtLCFTGDSKHASSA--RYVETQSMQIGASYMIQFSLVMG-------CGQqytPHMDNQ-VKLEYSTNHG 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 212549597 1545 ISWNLLRE--LDFM----SYLEPQI-----------ISIELPRNAKTSGTAFRWWQPQHGKQsAQWALDDVLIG 1601
Cdd:cd10038    92 LTWHLVQEecLPGMpscqEFTSGSIyhsseftewrrITLPLPQKTWSSATRFRWSQSYYTDQ-DEWALDNIYIG 164

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 49.82 E-value: 2.44e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  421 DQWSEEFEN-LPAGW-EIVGAVIGTECGTIESGASLVFLKDGERRVCTPYMDTTGYGNLRFHFVMGGM-----CSPGESH 493
Cdd:cd10047     2 SEFFDRFEGkLSPLWyKITGGQVGTGCGVIKDGKSLYFNGPGKREARTVPLDTTNIRLVQFYIQIGSKlngetCLRPRSR 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 212549597  494 ENDVLLYAQIDGRKDRIVMDTLAYSSYKAPSLVSSVISPDLQTPATKFCLKQNNHRGHNLNvWAVDFV 561
Cdd:cd10047    82 NEGIIVQYSNDNGITWHLLRELDFMSYLEPQVISIELPREAKTPATAFRWWQPQHGKPSAQ-WALDDV 148

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 49.78 E-value: 2.96e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  425 EEFEN---LPAGWEIV-GAVIGTECGTIESGASLVFLKDGERRVCTPYMDTTGYGNLRFHFVMGG-----MCSPGESHEN 495
Cdd:cd10051     6 ERFDSeeiSSDQWLSLeGGVTCTDCGVLAEGDALYFGGSGARQAVTQDLDLRGAKFVQYWARIGSennmtLCLRPTCRKE 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 212549597  496 DVLLYAQIDGRKDRIVMDTLAYSSYKAPSLVSSVISPDLQTPATKFCLKQNNHRGHNLNV-------WAVD 559
Cdd:cd10051    86 GVLLQYSTDGGISWTLLHELDYQKYISVRYDYITLPENARTNSTRLRWWQPFTISNGLVVsgteraqWALD 156

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 49.78 E-value: 3.01e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1808 LKDDFN----GNLHPDLWPEVYGGERGNLNGeTIKSGTALIFKG-DGLRMLISRDLDCTHTLYIQFSFKFITKGTPERSH 1882
Cdd:cd10036     1 LRDDFDsyplLELNNNIWSECCGCNVGEQCG-VIMHGNALTFCEpYGPRELITVPLNTTTASVLQFAIGSGSCRFSYSDP 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 212549597 1883 SILLQYSI-SGGITWHLMDEFyfTQTTDVLFVN--VPLPNTAQTNATRFRLWQPY-HNGKKDE-VWIIEDFVI 1950
Cdd:cd10036    80 SIIVSYAVnNTSSDWITLEKI--RAPSNGSTIIhiIPLPTDAKQDNVSFRFRQEApNAGEVYEsCWALDNVLI 150

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 49.92 E-value: 3.06e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1842 ALIFKGD-----GLRMLISRDLDCTHTLYIQFSFKFI--TKGTPERSHSILLQYSISGGITWHLMDE------------- 1901
Cdd:cd10038    33 TLCFTGDskhasSARYVETQSMQIGASYMIQFSLVMGcgQQYTPHMDNQVKLEYSTNHGLTWHLVQEeclpgmpscqeft 112

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 212549597 1902 ----FYFTQTTDVLFVNVPLPNTAQTNATRFRLWQPYHnGKKDEvWIIEDFVI 1950
Cdd:cd10038   113 sgsiYHSSEFTEWRRITLPLPQKTWSSATRFRWSQSYY-TDQDE-WALDNIYI 163

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 49.47 E-value: 3.24e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2574 TNAEFVQFYFMYGCLiiPHSRNQGVLLEYSVNGGINWFLLM---------------EIFY--DQYSKPGFVNILLPASAK 2636
Cdd:cd10037    42 TVTHFAQFSINLGCG--SHQPGNSVSLEFSTNHGRSWSLLHteclpelcagphlphSTVYssDNYSGWNRITIPLPNAAL 119

                          90       100
                  ....*....|....*....|....*...
gi 212549597 2637 TVGTRFRWWQPKhdGLDQNDWAIDNVLI 2664
Cdd:cd10037   120 TSATRFRWRQTG--SVVGSMWAIDNVYI 145

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 49.51 E-value: 3.87e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1957 NPAILLDTFDFGPNEENWFFYPGGNIALYCPYTSKGSpeedsAMVFvsNEVGEHSITTRDLDVDENTIIQFEINVGCTSD 2036
Cdd:cd10049     1 NPDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGN-----NLFF--NEDGLRMLVTRDLDLSMARFVQFFMRLGCGKG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2037 SSS--ADPVKLEFSRDFGATWHLLLPLCYSssshisslcstehhPSST---YYAGTTQGWRREvinfgklrlcGSIRFRW 2111
Cdd:cd10049    74 VPDprSQPVLLQYSLNGGLTWSLLQEFLFS--------------NSSNvgrYVALEIPLKARS----------PSTRLRW 129

                         170       180
                  ....*....|....*....|....*.
gi 212549597 2112 YQ----GFYpitMQPvtWAIDNIYIG 2133
Cdd:cd10049   130 WQpsenGHF---YSP--WVIDQILIG 150

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 49.79 E-value: 4.20e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2522 LKDTFNRAPSSHNWLTVNGGKLSSVCGAVASGMALHFSggcSRLLVSV----------DLNLTNAEFVQFYFMYGClIIP 2591
Cdd:cd10041     2 LLDTFDFGPNESNWLFYPGGNTGLYCPYQSKGAPEEDS---AMVFVSSelgehsittrDLDVNENTIIQFEINVGC-TTE 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2592 HSRNQGVLLEYSVNGGINWFLLM--------------------EIFYDQYSkPGFVN--ILLPASAKTVGTRFRWWQPKH 2649
Cdd:cd10041    78 SSSADPVRLEFSRDFGATWHLLLplcygsssisslcstelhpsSVYYTGTT-QGWRRevILFGKLHLCGSVRFRWYQGFH 156

                         170
                  ....*....|....*.
gi 212549597 2650 D-GLDQNDWAIDNVLI 2664
Cdd:cd10041   157 PaGSQPVTWAIDNVYI 172

C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197355 Cd Length: 151 Bit Score: 49.05 E-value: 4.77e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  567 LPSTESHMVQFSINLG-------CGSHQPGN-SVRLEFSTNHGRSWSLLHseclpELCAGSHLpHSTIyssdnysgwnrI 638
Cdd:cd10047    52 LDTTNIRLVQFYIQIGsklngetCLRPRSRNeGIIVQYSNDNGITWHLLR-----ELDFMSYL-EPQV-----------I 114

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 212549597  639 TIPLPNAALTRDTRLRWRQngPVMGN---MWALDNIYIG 674
Cdd:cd10047   115 SIELPREAKTPATAFRWWQ--PQHGKpsaQWALDDVLIG 151

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 48.70 E-value: 5.18e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2978 VLLDYSIDGGITWTLLHE-----------------MDYQKYMSVRYDYILLPENAQTNTTRLRWWQPFTVSNglvvlgqe 3040
Cdd:cd10037    64 VSLEFSTNHGRSWSLLHTeclpelcagphlphstvYSSDNYSGWNRITIPLPNAALTSATRFRWRQTGSVVG-------- 135

                          90
                  ....*....|..
gi 212549597 3041 rSQWALDNILIG 3052
Cdd:cd10037   136 -SMWAIDNVYIG 146

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 49.41 E-value: 5.23e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2325 TVIEDDF--SSLDNKKWLLHPGGTKMSVCGS-----SGDALVFiEKASTRYVVTTDIVVNEDSF----LQIdfaASCSVT 2393
Cdd:cd10052     2 SYIKDNFesGSVSELKWSLIQGGGIGSGCGQlaphaHGDSLYF-NGCGIRQAVTVELDLTRASKimfvLQI---GSRSQT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2394 DSCY-----------AIELEYSVDLGLSWnpvlkdclptnvecsnyQLQRALVSDTFNKWTRFTLPLPPYTRSQATRFRW 2462
Cdd:cd10052    78 DSCNinlsspravdkAVLLQYSVNNGITW-----------------YLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRW 140

                         170
                  ....*....|....*...
gi 212549597 2463 NQPSPFDK-QQTWAIDNV 2479
Cdd:cd10052   141 WQPRHDGTgHDQWALDNV 158

C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197359 Cd Length: 162 Bit Score: 49.01 E-value: 5.55e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1243 YEKPAFDYPVNQMNVWLMLANeGMPKNESFCSLTPSAMIFGKSdGDRFAVTRDLTLKPGYVLQFKLNVGCTNEFSGMAP- 1321
Cdd:cd10051     3 FLKERFDSEEISSDQWLSLEG-GVTCTDCGVLAEGDALYFGGS-GARQAVTQDLDLRGAKFVQYWARIGSENNMTLCLRp 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 212549597 1322 ------VLLQYSHDAGLSWSLVREGCYpaspgikdcegssrelgepTSYYTGDYEdwtriTIVIPRSLASSKTRFRWIQ 1394
Cdd:cd10051    81 tcrkegVLLQYSTDGGISWTLLHELDY-------------------QKYISVRYD-----YITLPENARTNSTRLRWWQ 135

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 49.40 E-value: 5.63e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1456 DRFE-GKLSQQWYKITGGQVGTGC------GVLSDGKSLYL-NGPGKREARTAALDTTNTRLIQFYIQIGNTNGGSTcgk 1527
Cdd:cd10041     4 DTFDfGPNESNWLFYPGGNTGLYCpyqskgAPEEDSAMVFVsSELGEHSITTRDLDVNENTIIQFEINVGCTTESSS--- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1528 pkarNEGVVVQYTNDNGISWNLLRELDFMS---------YLEP------------QIISIELPRNAKTSGTAFRWWQPQH 1586
Cdd:cd10041    81 ----ADPVRLEFSRDFGATWHLLLPLCYGSssisslcstELHPssvyytgttqgwRREVILFGKLHLCGSVRFRWYQGFH 156

                         170
                  ....*....|....*..
gi 212549597 1587 --GKQSAQWALDDVLIG 1601
Cdd:cd10041   157 paGSQPVTWAIDNVYIG 173

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 48.73 E-value: 5.68e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  567 LPSTESHMVQFSINLGC-GSHQPGNSVRLEFSTNHGRSWSLLHSECLPElcagshlPHSTIYssdnysgwnrITIPLPNA 645
Cdd:cd10048    55 LDCTHTLYIQFSFKFITkGTPERSHSVLLQYSINGGITWHLIDEFYFPT-------TTDVLF----------VNVPLPYT 117

                          90       100       110
                  ....*....|....*....|....*....|.
gi 212549597  646 ALTRDTRLR-WR-QNGPVMGNMWALDNIYIG 674
Cdd:cd10048   118 AQTNATRFRlWQpYNSGKKEEVWILDDLVID 148

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 48.36 E-value: 9.37e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2896 LKERFDSEEIRSdfWLSVDGGKTCTDCGVlAEDMALYFGASAVRQTITQDLDLRGAKFVQYWARIGSENMTSCRkpvcrk 2975
Cdd:cd10042     2 LEDDFSTLDSRK--WLLHPGGTKMPVCGS-TGDALVFIEKASTRYVVTTDIMVNEDSFLQIDFAASCSVTDSCY------ 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2976 eGVLLDYSIDGGITW--------------------TLLHEMDYQKYMSVRydyILLPENAQTNTTRLRWWQPFTVSNGlv 3035
Cdd:cd10042    73 -AIELEYSVDLGLSWhpllrdclptnvecssyhlqRILVSDTFNKWTRVT---LPLPHYTRSQATRFRWHQPAPFDKQ-- 146

                         170
                  ....*....|....*..
gi 212549597 3036 vlgqerSQWALDNILIG 3052
Cdd:cd10042   147 ------QTWAIDNVYIG 157

N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197347 Cd Length: 170 Bit Score: 48.28 E-value: 1.22e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1808 LKDDFNGNL-HPDLWpEVYGGERGNLNGETIKSGTALIF-KGDGLRMLISRDLDCTHTLYIQFsfKFITKGTPERSHS-- 1883
Cdd:cd10039     2 EKPAFDYPLnQMSVW-LMLSNEGMGKNESCSPTPSAMVFgKSDGDRFAVTRDLTLKPGYVLQF--KVNIGCTSEFSSFap 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1884 ILLQYSISGGITWHLMDE------------------------FYFTQTTDVLFVNVPLPNTAQTNATRFRLWQPYHNGKK 1939
Cdd:cd10039    79 VLLQYSHDAGLTWSLVREgcypaspgskgcegssrelreptvYHTGDYEDWTRITIPIPRSLAASKTRFRWIQESSSLKN 158

                         170
                  ....*....|.
gi 212549597 1940 DEVWIIEDFVI 1950
Cdd:cd10039   159 APPFGLDGVYI 169

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 47.85 E-value: 1.32e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  435 EIVGAVIGTECGTIESGASLVFLK-DGERRVCTPYMDTTGYGNLRFHFVMGGmCSPGESHENDVLLYAQIDGRKDRIVMD 513
Cdd:cd10036    20 ECCGCNVGEQCGVIMHGNALTFCEpYGPRELITVPLNTTTASVLQFAIGSGS-CRFSYSDPSIIVSYAVNNTSSDWITLE 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 212549597  514 TLayssyKAPSLVSSVI-----SPDLQTPATKFCLKQNN-HRGHNL-NVWAVDFVHVL 564
Cdd:cd10036    99 KI-----RAPSNGSTIIhiiplPTDAKQDNVSFRFRQEApNAGEVYeSCWALDNVLII 151

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 47.87 E-value: 1.48e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1958 PAILLDTFDFGPNEENWFFYP--GGNIALYCPYTSKGSpeedsAMVFvsNEVGEHSITTRDLDVDENTIIQFEINVGCTS 2035
Cdd:cd10045     1 PGFLSESFNSSRLSSYHNFSSirGGEVGFGCGVLASGK-----ALVF--NGDGRRQLITAPLDSTQSRYLQFTLRLGSKS 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2036 DSSSADP-------VKLEFSRDFGATWHLLLPLCYSssshisslcstEHHPSSTYYAGTTQGWRreviNFGklrlcgsIR 2108
Cdd:cd10045    74 VLGTCPPpdrpgegVLLHYSCDNGITWKLLEHYSYD-----------NYHEPRIVSVELPEDAR----NFG-------VQ 131

                         170       180
                  ....*....|....*....|....
gi 212549597 2109 FRWYQGFYPITMQPVtWAIDNIYI 2132
Cdd:cd10045   132 FRWWQPYHSGQNQDV-WALDEISM 154

N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197349 Cd Length: 174 Bit Score: 48.25 E-value: 1.62e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1072 IMSDFEGLNGwETDWLEVVGGEIVK--PEQGCGIISSGSSMYFYKD--GRRQLVSLDMDTTWVDFIQFYIQIGgettsCN 1147
Cdd:cd10041     2 LLDTFDFGPN-ESNWLFYPGGNTGLycPYQSKGAPEEDSAMVFVSSelGEHSITTRDLDVNENTIIQFEINVG-----CT 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1148 KPDSREEGVLLQYSNNGGINWHLLAEMYFSDFIKSKFVYLEL-PNAARTPCT--------------------RFRWWQPV 1206
Cdd:cd10041    76 TESSSADPVRLEFSRDFGATWHLLLPLCYGSSSISSLCSTELhPSSVYYTGTtqgwrrevilfgklhlcgsvRFRWYQGF 155

                         170
                  ....*....|....*..
gi 212549597 1207 F-SGEGYDQWAIDDVII 1222
Cdd:cd10041   156 HpAGSQPVTWAIDNVYI 172

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 47.91 E-value: 1.72e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2217 LVTRDLDLSLARFVQFFMRLGCGKAVPDPRSQPVLLQFSLDGGL-SWSVLQE--------------FHF-------SNSS 2274
Cdd:cd10044    53 LTTRQLIVQPGYMIQFKIVVGCGSVSSCGDLHPVMLEYTTDPRSdHWQLVQTeclpsssnsidcspFQYheasiysSVNS 132

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 212549597 2275 NVGRYVALEIPLKARSPSTRLRWWQPSENGhFYSPWVIDQILIG 2318
Cdd:cd10044   133 SVWKRVTIQLPDHVSSSATQFRWIQKTEST-EAPSWAIDDVYIG 175

C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197354 [Multi-domain] Cd Length: 156 Bit Score: 47.54 E-value: 1.97e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1971 EENWFFYPGGNIALycPYTSKGSPEEDSAMVFvsNEVGEHSITTRDLDVDENTIIQFEINVG-----CTSDSSSADPVKL 2045
Cdd:cd10046    16 ETEWQEVIGGEIVK--PEMGCGVISSGSSLYF--NKDGLRQLVSWDLDTTWVDFIQFYIQIGggsasCNYPDSREEGVLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2046 EFSRDFGATWHLLLPLCYSSSSHisslcstehhPSSTYYagttqgwrrEVINFGKLRlcgSIRFRWYqgfypitmQPV-- 2123
Cdd:cd10046    92 QYSNNGGISWKLLAEMYFSDFSK----------PRFVYL---------ELPTAAKTP---CTRFRWW--------QPVfs 141

                         170
                  ....*....|....*
gi 212549597 2124 -----TWAIDNIYIG 2133
Cdd:cd10046   142 gegydQWALDDIIIL 156

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 47.59 E-value: 1.99e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1807 ILKDDFNGN------LHPdlwpevyGGERGNLNGETiksGTALIF-KGDGLRMLISRDLDCTHTLYIQFSFKFITKGTpE 1879
Cdd:cd10042     1 VLEDDFSTLdsrkwlLHP-------GGTKMPVCGST---GDALVFiEKASTRYVVTTDIMVNEDSFLQIDFAASCSVT-D 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1880 RSHSILLQYSISGGITWH-LMDEFYFTQT------------TDVLF----VNVPLPNTAQTNATRFRLWQPYHNGKKDEv 1942
Cdd:cd10042    70 SCYAIELEYSVDLGLSWHpLLRDCLPTNVecssyhlqrilvSDTFNkwtrVTLPLPHYTRSQATRFRWHQPAPFDKQQT- 148


                  ....*...
gi 212549597 1943 WIIEDFVI 1950
Cdd:cd10042   149 WAIDNVYI 156

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 47.21 E-value: 2.25e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1456 DRFEGKLSQQWYKITGGQVGTGCGvlSDGKSL-YLNGPGKREARTAALDTTNTRLIQFYIQIGNTNGGSTcgkpkarnEG 1534
Cdd:cd10042     4 DDFSTLDSRKWLLHPGGTKMPVCG--STGDALvFIEKASTRYVVTTDIMVNEDSFLQIDFAASCSVTDSC--------YA 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1535 VVVQYTNDNGISWN-LLRE-----LDFMSYLEPQI-----------ISIELPRNAKTSGTAFRWWQPQHGKQSAQWALDD 1597
Cdd:cd10042    74 IELEYSVDLGLSWHpLLRDclptnVECSSYHLQRIlvsdtfnkwtrVTLPLPHYTRSQATRFRWHQPAPFDKQQTWAIDN 153


                  ....
gi 212549597 1598 VLIG 1601
Cdd:cd10042   154 VYIG 157

N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197345 Cd Length: 146 Bit Score: 46.78 E-value: 2.66e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1132 FIQFYIQIGGETtscNKPDSreeGVLLQYSNNGGINWHLL----------------AEMYFSDFIKS-KFVYLELPNAAR 1194
Cdd:cd10037    46 FAQFSINLGCGS---HQPGN---SVSLEFSTNHGRSWSLLhteclpelcagphlphSTVYSSDNYSGwNRITIPLPNAAL 119

                          90       100
                  ....*....|....*....|....*....
gi 212549597 1195 TPCTRFRWWQPvfSGEGYDQWAIDDVIIL 1223
Cdd:cd10037   120 TSATRFRWRQT--GSVVGSMWAIDNVYIG 146

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 46.81 E-value: 2.86e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  570 TESHMVQFSINLGCGSHQP---GNSVRLEFSTNHGRSWSLLHSeclpelcagshlphstiYSSDNYSGWNR-ITIPLPNA 645
Cdd:cd10049    57 SMARFVQFFMRLGCGKGVPdprSQPVLLQYSLNGGLTWSLLQE-----------------FLFSNSSNVGRyVALEIPLK 119

                          90       100       110
                  ....*....|....*....|....*....|..
gi 212549597  646 ALTRDTRLRWRQ---NGPVMgNMWALDNIYIG 674
Cdd:cd10049   120 ARSPSTRLRWWQpseNGHFY-SPWVIDQILIG 150

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 46.41 E-value: 4.52e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  431 PAGW-EIVGAVIGTECG-TIESGASLVFLKDGERRVCTPYMDTTGYGNLRFHFVMGGMCSPGESHEndVLLYAQIDGRKD 508
Cdd:cd10048    15 PDLWpEVYGAERGNLNGeTIKSGTALIFKGEGLRMLVSRDLDCTHTLYIQFSFKFITKGTPERSHS--VLLQYSINGGIT 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 212549597  509 RIVMDTLaYSSYKAPSLVSSVISPDL-QTPATKFCLKQNNHRGHNLNVWAVD 559
Cdd:cd10048    93 WHLIDEF-YFPTTTDVLFVNVPLPYTaQTNATRFRLWQPYNSGKKEEVWILD 143

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 45.93 E-value: 5.24e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1610 FQDKFDGSVDLHAN---WYRIQGGQVDVDC--LSMDTALLFNENIGkPRYAETWDFHVMPSSSLQFNLNMGCSKQLSNSH 1684
Cdd:cd10036     1 LRDDFDSYPLLELNnniWSECCGCNVGEQCgvIMHGNALTFCEPYG-PRELITVPLNTTTASVLQFAIGSGSCRFSYSDP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1685 VVQLQFSVNNGR-DWQQVTEECIPPSIgclhytessvysserfQTSKRItVYLPSATVSPRTRFRWIQYNYGSGA---DA 1760
Cdd:cd10036    80 SIIVSYAVNNTSsDWITLEKIRAPSNG----------------STIIHI-IPLPTDAKQDNVSFRFRQEAPNAGEvyeSC 142


                  ....*...
gi 212549597 1761 WAIDNVVL 1768
Cdd:cd10036   143 WALDNVLI 150

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 42.33 E-value: 5.90e-05

                           10        20
                   ....*....|....*....|....*
gi 212549597  2140 CNGHGSCINGT-KCICDPGYSGPTC 2163
Cdd:pfam07974    2 CSGRGTCVNQCgKCVCDSGYQGATC 26

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 45.18 E-value: 1.00e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  567 LPSTESHMVQFSINLGCGS--------HQPGNSVRLEFSTNHGRSWSLLHseclpelcagshlphstIYSSDNYSGWNRI 638
Cdd:cd10045    55 LDSTQSRYLQFTLRLGSKSvlgtcpppDRPGEGVLLHYSCDNGITWKLLE-----------------HYSYDNYHEPRIV 117

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 212549597  639 TIPLPNAALTRDTRLRWRQ--NGPVMGNMWALDNIYI 673
Cdd:cd10045   118 SVELPEDARNFGVQFRWWQpyHSGQNQDVWALDEISM 154

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 45.28 E-value: 1.01e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  741 CGVlaSGKALIF-NKDGRRQLITAFLDSSQSRFLQFTLRIGSkSVLSTCKApdkpgegVLLHYSHDNGITWK------LM 813
Cdd:cd10042    26 CGS--TGDALVFiEKASTRYVVTTDIMVNEDSFLQIDFAASC-SVTDSCYA-------IELEYSVDLGLSWHpllrdcLP 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  814 EHYSYLSYHEPRI-----------ISVELPEDAKQFGIQFRWWQPYHSGQGEDvWAIDEI 862
Cdd:cd10042    96 TNVECSSYHLQRIlvsdtfnkwtrVTLPLPHYTRSQATRFRWHQPAPFDKQQT-WAIDNV 154

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 45.29 E-value: 1.15e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  749 ALIFNKD-----GRRQLITAFLDSSQSRFLQFTLRIGsksvlstCKAPDKPG--EGVLLHYSHDNGITWKLM-------- 813
Cdd:cd10038    33 TLCFTGDskhasSARYVETQSMQIGASYMIQFSLVMG-------CGQQYTPHmdNQVKLEYSTNHGLTWHLVqeeclpgm 105

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 212549597  814 ----EHYSYLSYH-----EPRIISVELPEDAKQFGIQFRWWQPYHSGQgeDVWAIDEI 862
Cdd:cd10038   106 pscqEFTSGSIYHsseftEWRRITLPLPQKTWSSATRFRWSQSYYTDQ--DEWALDNI 161

C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197358 [Multi-domain] Cd Length: 148 Bit Score: 44.83 E-value: 1.24e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  567 LPSTESHMVQFSINLGC--GSHQPGNSVRLEFSTNHGRSWSLLHSeclpelcagshlphstIYSsDNYSGWNRITIPLPN 644
Cdd:cd10050    54 LNLTNAEFVQFYFMYGCliPPSNRNQGVLLEYSVNGGITWNLLME----------------IFY-DQYSKPGFVNILLPP 116

                          90       100       110
                  ....*....|....*....|....*....|...
gi 212549597  645 AALTRDTRLRWRQ---NGPVMgNMWALDNIYIG 674
Cdd:cd10050   117 EARGVGTRFRWWQpshDGLDQ-NDWAIDNVLIG 148

N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197346 Cd Length: 168 Bit Score: 44.52 E-value: 2.66e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3299 GQLSPYA-HGDSLYFNG-----CQIRQAITKPLDLTRASKIMFVLQIGSIAQTdscntnlsdTNTVDKAVLLQYSVNNGI 3372
Cdd:cd10038    22 GNVQPYCnHDWTLCFTGdskhaSSARYVETQSMQIGASYMIQFSLVMGCGQQY---------TPHMDNQVKLEYSTNHGL 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 212549597 3373 TWQVI-----------------AQHQPKDFIQAQRVSYNIPLEARMKGVLLRWWQpRHNGIGhDQWALDHVEV 3428
Cdd:cd10038    93 TWHLVqeeclpgmpscqeftsgSIYHSSEFTEWRRITLPLPQKTWSSATRFRWSQ-SYYTDQ-DEWALDNIYI 163

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 44.54 E-value: 2.78e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2217 LVTRDLDLSLARFVQFFMRLGCGKAVPDPRsQPVLLQFSLDGGLSWSVLQEFHFSNSSNVG---------------RYVA 2281
Cdd:cd10043    60 AVTHDLTPTEGWILQFKISVGCKSSEKSAQ-QPVHVQYSTDFGVSWSYVTPQCLPSDPKCGgsvtqpsvffpskgwRRVT 138

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 212549597 2282 LEIPLKARSPSTRLRWWQpsenGHFYSPWVIDQILIG 2318
Cdd:cd10043   139 IPLPDKLVGRPIRFRFYQ----KASDMQWALDNFYIG 171

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 44.02 E-value: 3.31e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2742 REVYTVTHDLTPAEGwiMQFKIAVGCR----------SSEKNVQNQVHVQYSTDFGVSWtYLVPQCLPADpkcsgtVSQP 2811
Cdd:cd10052    50 RQAVTVELDLTRASK--IMFVLQIGSRsqtdscninlSSPRAVDKAVLLQYSVNNGITW-YLIAQHQPKD------FMRA 120

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 212549597 2812 svffpakgwKRVTYTLPDSLIGNPVRFRFYQKYSDM----QWAIDN 2853
Cdd:cd10052   121 ---------QRVSYNLPLEARTKGVVLRWWQPRHDGtghdQWALDN 157

C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197353 [Multi-domain] Cd Length: 155 Bit Score: 43.64 E-value: 3.38e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1279 AMIFGKsDGDRFAVTRDLTLKPGYVLQFKLNVGCTNEFSGMAP-------VLLQYSHDAGLSWSLVREGCYpaspgikdc 1351
Cdd:cd10045    39 ALVFNG-DGRRQLITAPLDSTQSRYLQFTLRLGSKSVLGTCPPpdrpgegVLLHYSCDNGITWKLLEHYSY--------- 108

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 212549597 1352 egssRELGEPTSyytgdyedwtrITIVIPRSLASSKTRFRWIQESSSFSNVPAFGLDGVYIS 1413
Cdd:cd10045   109 ----DNYHEPRI-----------VSVELPEDARNFGVQFRWWQPYHSGQNQDVWALDEISMT 155

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 42.59 E-value: 9.39e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  205 LRDDFDSyklqeLNPNIWLQCRNCEVGEQCGVimHSGAVTFCDPYGPRELISVQMNTTTASVLQFSIgSGSCRFSYSDPG 284
Cdd:cd10042     2 LEDDFST-----LDSRKWLLHPGGTKMPVCGS--TGDALVFIEKASTRYVVTTDIMVNEDSFLQIDF-AASCSVTDSCYA 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  285 IVVSYTKNNSSSWVPLERISAPSNV--------STIIHIIY---------LPPEVKGDSVKFRWRQEnmqAGDVYEACWA 347
Cdd:cd10042    74 IELEYSVDLGLSWHPLLRDCLPTNVecssyhlqRILVSDTFnkwtrvtlpLPHYTRSQATRFRWHQP---APFDKQQTWA 150


                  ....*.
gi 212549597  348 LDNILI 353
Cdd:cd10042   151 IDNVYI 156

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.87 E-value: 1.15e-03

                           10        20
                   ....*....|....*....|....*
gi 212549597  1040 CSGHGWCDH--GICRCDSGYQGSQC 1062
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 42.52 E-value: 1.20e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1451 PSEMFDRFEGK---LSQQWYKITGGQVGTG-CGVLSDGKSLYLNGPGKRE--ARTAALDTTNTRLIQFYIQIGnTNGGST 1524
Cdd:cd10044     1 PSSLVETFEDEgtsHDENWEFYPNGVRTDEfCGNPSFHLTWPNKKKDKTHnaLTTRQLIVQPGYMIQFKIVVG-CGSVSS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1525 CGKpkarNEGVVVQYTND-NGISWNLLRE-----------LDFMSYLEPQI-----------ISIELPRNAKTSGTAFRW 1581
Cdd:cd10044    80 CGD----LHPVMLEYTTDpRSDHWQLVQTeclpsssnsidCSPFQYHEASIyssvnssvwkrVTIQLPDHVSSSATQFRW 155

                         170       180
                  ....*....|....*....|
gi 212549597 1582 WQPQHGKQSAQWALDDVLIG 1601
Cdd:cd10044   156 IQKTESTEAPSWAIDDVYIG 175

Additional N-terminal subrepeat of reelin; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. Some family members appear to have an additional subrepeat at the N-terminus as characterized in this model. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1). Genetic deficiency of reelin, or ApoER2 and VLDLR, or Dab1, all exhibit the same phenotypes, including ataxia, cortical layer inversion and abnormal positioning patterns.

Pssm-ID: 197344 Cd Length: 151 Bit Score: 42.07 E-value: 1.26e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  915 PRYVETQSMQIGASYMIQFSLVMG-CGERYTphmDNQVMLEYSTN-HGLTWHLVQQeclPSMPScqefTSSSIYHsseft 992
Cdd:cd10036    47 PRELITVPLNTTTASVLQFAIGSGsCRFSYS---DPSIIVSYAVNnTSSDWITLEK---IRAPS----NGSTIIH----- 111

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 212549597  993 hwrriTLPLPQKTWSGATRFRWSQRYYTSDDE----WALDNIYI 1032
Cdd:cd10036   112 -----IIPLPTDAKQDNVSFRFRQEAPNAGEVyescWALDNVLI 150

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.48 E-value: 1.30e-03

                           10        20
                   ....*....|....*....|....*.
gi 212549597  3237 LCSGHGYC-TTGAICLCDEGYQGDDC 3261
Cdd:pfam07974    1 ICSGRGTCvNQCGKCVCDSGYQGATC 26

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 38.48 E-value: 1.44e-03

                           10        20
                   ....*....|....*....|....*
gi 212549597  2864 CNGHGDCLRE--QCICDSGYSGPNC 2886
Cdd:pfam07974    2 CSGRGTCVNQcgKCVCDSGYQGATC 26

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.

Pssm-ID: 376143 Cd Length: 29 Bit Score: 38.05 E-value: 1.86e-03

                           10        20
                   ....*....|....*....|....*....
gi 212549597  3234 CPKLCSGHGYCTTGAiCLCDEGYQGDDCS 3262
Cdd:pfam18720    2 CPLGCSSRGVCVDGQ-CICDSEYSGDDCS 29

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 41.41 E-value: 1.96e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1278 SAMIFgKSDGDRFAVTRDLTLKPGYVLQFKLNVGCTNEFSGMAPVLLQYSHDAGLSWSLVREGCYPASpgikdcegssre 1357
Cdd:cd10048    38 TALIF-KGEGLRMLVSRDLDCTHTLYIQFSFKFITKGTPERSHSVLLQYSINGGITWHLIDEFYFPTT------------ 104

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 212549597 1358 lgeptsyytgdyEDWTRITIVIPRSLASSKTRFRWIQESSSFSNVPAFGLDGVYI 1412
Cdd:cd10048   105 ------------TDVLFVNVPLPYTAQTNATRFRLWQPYNSGKKEEVWILDDLVI 147

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 41.32 E-value: 2.39e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  579 INLGcGSHQPGNSVRLEFSTNHGRSWSLLHseclpelcagSHLPhstiyssDNYSGWNRITIPLPNAALTRDTRLRW--- 655
Cdd:cd10052    82 INLS-SPRAVDKAVLLQYSVNNGITWYLIA----------QHQP-------KDFMRAQRVSYNLPLEARTKGVVLRWwqp 143

                          90
                  ....*....|....*.
gi 212549597  656 RQNGpVMGNMWALDNI 671
Cdd:cd10052   144 RHDG-TGHDQWALDNV 158

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 41.46 E-value: 2.44e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1101 CGIISSGSSMYfykdgrrqLVSLDMDTTWVDFIQFYIQIGGETTScnkpDSREEGVLLQYSNNGGINWHLLAEMYFS--- 1177
Cdd:cd10043    49 CGSHDDGREVS--------AVTHDLTPTEGWILQFKISVGCKSSE----KSAQQPVHVQYSTDFGVSWSYVTPQCLPsdp 116

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 212549597 1178 DFIKS-------------KFVYLELPNAARTPCTRFRWWQpvfsGEGYDQWAIDDVII 1222
Cdd:cd10043   117 KCGGSvtqpsvffpskgwRRVTIPLPDKLVGRPIRFRFYQ----KASDMQWALDNFYI 170

C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197360 [Multi-domain] Cd Length: 161 Bit Score: 41.32 E-value: 2.58e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  434 WEIV-GAVIGTECGTIE---SGASLVFLKDGERRVCTPYMDTTGYGNLRFHFVMGGM-----C----SPGESHENDVLLY 500
Cdd:cd10052    18 WSLIqGGGIGSGCGQLAphaHGDSLYFNGCGIRQAVTVELDLTRASKIMFVLQIGSRsqtdsCninlSSPRAVDKAVLLQ 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 212549597  501 AQIDGRKDRIVMDTLAYSSYKAPSLVSSVISPDLQTPATKFCLKQNNHRGHNLNVWAVDFVHVL 564
Cdd:cd10052    98 YSVNNGITWYLIAQHQPKDFMRAQRVSYNLPLEARTKGVVLRWWQPRHDGTGHDQWALDNVEVV 161

N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197352 Cd Length: 176 Bit Score: 41.36 E-value: 2.87e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2519 PTQLKDTFNRAPSSH--NW-LTVNGGKLSSVCGAVASGM--ALHFSGGCSRLLVSVDLNLTNAEFVQFYFMYGCLIIPH- 2592
Cdd:cd10044     1 PSSLVETFEDEGTSHdeNWeFYPNGVRTDEFCGNPSFHLtwPNKKKDKTHNALTTRQLIVQPGYMIQFKIVVGCGSVSSc 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2593 SRNQGVLLEYSVNGGIN-WFLLME---------------IFYDQ--YSKPGF-----VNILLPASAKTVGTRFRWWQpKH 2649
Cdd:cd10044    81 GDLHPVMLEYTTDPRSDhWQLVQTeclpsssnsidcspfQYHEAsiYSSVNSsvwkrVTIQLPDHVSSSATQFRWIQ-KT 159

                         170
                  ....*....|....*
gi 212549597 2650 DGLDQNDWAIDNVLI 2664
Cdd:cd10044   160 ESTEAPSWAIDDVYI 174

C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197357 [Multi-domain] Cd Length: 150 Bit Score: 40.65 E-value: 4.31e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597  438 GAVIGTECGTIESGASLVFLKDGERRVCTPYMDTTGYGNLRFHFVMGGMCSPGESHENDVLLYAQIDGRKDRIVMDTLAY 517
Cdd:cd10049    23 GGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSMARFVQFFMRLGCGKGVPDPRSQPVLLQYSLNGGLTWSLLQEFLF 102

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 212549597  518 S-SYKAPSLVSSVISPDLQTPATKFCLKQNNHRGHNLNVWAVD 559
Cdd:cd10049   103 SnSSNVGRYVALEIPLKARSPSTRLRWWQPSENGHFYSPWVID 145

EB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 8 conserved cysteines that probably form four disulphide bridges. This domain is found associated with kunitz domains pfam00014.

Pssm-ID: 460294 Cd Length: 52 Bit Score: 37.79 E-value: 4.71e-03

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 212549597  1410 VYISEPC--PSYCNGYGDCVSGVCFCDRGYTAEHGTC 1444
Cdd:pfam01683   16 VAPGESCeaDEQCPGGSVCVNGVCQCPPGFTPVNGRC 52

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.

Pssm-ID: 400365 Cd Length: 26 Bit Score: 36.94 E-value: 5.07e-03

                           10        20
                   ....*....|....*....|....*
gi 212549597  1776 CSGHGICDS--GHCVCDRGFGGPYC 1798
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26

C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the C-terminal subrepeat, which directly contacts the N-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197356 [Multi-domain] Cd Length: 150 Bit Score: 40.25 E-value: 5.46e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 2747 VTHDLTPAEGWIMQFKIAVGCRSSEKNvQNQVHVQYSTDFGVSWtYLVPQCLPadpkcsgTVSQPSVFFPAKgwkrvtyt 2826
Cdd:cd10048    51 VSRDLDCTHTLYIQFSFKFITKGTPER-SHSVLLQYSINGGITW-HLIDEFYF-------PTTTDVLFVNVP-------- 113

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 212549597 2827 LPDSLIGNPVRFRFYQKYSDMQ----WAIDNFYIG 2857
Cdd:cd10048   114 LPYTAQTNATRFRLWQPYNSGKkeevWILDDLVID 148

N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197350 Cd Length: 157 Bit Score: 40.27 E-value: 5.66e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3272 IKDNFESekVTEINWENIQGGVIGNGCGqlspyAHGDSLYF-NGCQIRQAITKPLDLTRASKIMFVLQIGSIAqTDSCnt 3350
Cdd:cd10042     2 LEDDFST--LDSRKWLLHPGGTKMPVCG-----STGDALVFiEKASTRYVVTTDIMVNEDSFLQIDFAASCSV-TDSC-- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 3351 nlsdtntvdKAVLLQYSVNNGITWQ-VIAQHQPKD----------------FIQAQRVSYNIPLEARMKGVLLRWWQPRH 3413
Cdd:cd10042    72 ---------YAIELEYSVDLGLSWHpLLRDCLPTNvecssyhlqrilvsdtFNKWTRVTLPLPHYTRSQATRFRWHQPAP 142

                         170
                  ....*....|...
gi 212549597 3414 NGIGHdQWALDHV 3426
Cdd:cd10042   143 FDKQQ-TWAIDNV 154

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

Pssm-ID: 238011 Cd Length: 38 Bit Score: 36.85 E-value: 5.94e-03

                          10        20        30
                  ....*....|....*....|....*....|....
gi 212549597 2136 CEEM--CNGHGSCIN---GTKCICDPGYSGPTCK 2164
Cdd:cd00054     5 CASGnpCQNGGTCVNtvgSYRCSCPPGYTGRNCE 38

N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins; Reelin is an extracellular glycoprotein involved in neuronal development, specifically in the brain cortex. It contains 8 tandemly repeated units, each of which is composed of two highly similar subrepeats and a central EGF domain. This model characterizes the N-terminal subrepeat, which directly contacts the C-terminal subrepeat and the EGF domain in a compact arrangement. Consecutive reelin repeat units are packed together to form an overall rod-like molecular structure. Reelin repeats 5 and 6 are reported to interact with neuronal receptors, the apolipoprotein E receptor 2 (ApoER2) and the very-low-density lipoprotein receptor (VLDLR), triggering a signaling cascade upon binding and subsequent tyrosine phosphorylation of the cytoplasmic disabled-1 (Dab1).

Pssm-ID: 197351 Cd Length: 171 Bit Score: 39.92 E-value: 8.87e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 212549597 1478 CGVLSDGKSLYLNgpgkrearTAALDTTNTRLIQFYIQIGntnggstCGKP-KARNEGVVVQYTNDNGISWNLL------ 1550
Cdd:cd10043    49 CGSHDDGREVSAV--------THDLTPTEGWILQFKISVG-------CKSSeKSAQQPVHVQYSTDFGVSWSYVtpqclp 113

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 212549597 1551 RELDFM-SYLEPQI---------ISIELPRNAKTSGTAFRWWQpqhGKQSAQWALDDVLIG 1601
Cdd:cd10043   114 SDPKCGgSVTQPSVffpskgwrrVTIPLPDKLVGRPIRFRFYQ---KASDMQWALDNFYIG 171