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Conserved domains on  [gi|224451128|ref|NP_001136272|]
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protein eyes shut homolog isoform 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
2719-2856 9.90e-25

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 102.03  E-value: 9.90e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128   2719 HIQLQFQPLAADGILFYAAQHLKaqsGDFLCISLVNSSVQLRYNLGDRTIILeTLQKVTINGSTWHIIKAGRVGAEGYLD 2798
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG---GDYLALELRDGRLVLRYDLGSGPARL-TSDPTPLNDGQWHRVAVERNGRSVTLS 76

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 224451128   2799 LDGIN-VTEKASTKMSSLDTNTDFYIGGVSSLNLVNPMAIENepvGFQGCIRQVIINNQ 2856
Cdd:smart00282   77 VDGGNrVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTP---GFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
2459-2582 1.45e-19

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 87.01  E-value: 1.45e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128   2459 NNLIFFTGQKghglNGDDFLAVGLLNGSVVYSYNLGSGIASIRSEPLNLSLGV-HTVHLGKFFQEGWLKVDDHKNKSIIA 2537
Cdd:smart00282   12 NGLLLYAGSK----GGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQwHRVAVERNGRSVTLSVDGGNRVSGES 87

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 224451128   2538 PGRLVGLNVFSQFYVGGyseYTPDLLPNGADFKNGFQGCIFTLQV 2582
Cdd:smart00282   88 PGGLTILNLDGPLYLGG---LPEDLKLPPLPVTPGFRGCIRNLKV 129
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2956-3117 8.05e-17

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 80.15  E-value: 8.05e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128 2956 TAKFMGNSYIKYIDPNYRMRNlqfTTISLNFSTTKTEGLIVWMGiaQNEENDFLAIGLHNQTLKIAVNLGE---RISVPM 3032
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPRTR---LSISFSFRTTSPNGLLLYAG--SQNGGDFLALELEDGRLVLRYDLGSgslVLSSKT 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128 3033 SYNNGtfccnKWHHVVVIQNQTLIKAYINNSLILseDIDPHKNFVALNYDGICYLGGFEYGRKVNIVTQEifkTNFVGKI 3112
Cdd:cd00110    76 PLNDG-----QWHSVSVERNGRSVTLSVDGERVV--ESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVS---PGFVGCI 145


                  ....*
gi 224451128 3113 KDVVF 3117
Cdd:cd00110   146 RDLKV 150
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2149-2315 1.34e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 79.38  E-value: 1.34e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128 2149 SFNGNSYLELPFLKFVLEKEhnrtvTIYLTIKTNSLNGTILYsNGNNCGKQFLHLFLVEGRPSVKYGCGNSQniLTVSAN 2228
Cdd:cd00110     3 SFSGSSYVRLPTLPAPRTRL-----SISFSFRTTSPNGLLLY-AGSQNGGDFLALELEDGRLVLRYDLGSGS--LVLSSK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128 2229 YSINTNAFTPITIRYTTPVgspgvvcmIEMTADGKPPVQKKDTEiSHASQAYFESMFLGHIPANVQIHKKAgPVYGFRGC 2308
Cdd:cd00110    75 TPLNDGQWHSVSVERNGRS--------VTLSVDGERVVESGSPG-GSALLNLDGPLYLGGLPEDLKSPGLP-VSPGFVGC 144


                  ....*..
gi 224451128 2309 ILDLQVN 2315
Cdd:cd00110   145 IRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1886-2044 5.20e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 77.84  E-value: 5.20e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128 1886 VRYYGDSYLEFQN-VALNPQNNISLEFQTFSSYGLLLYVkQDSNLVDgfFIQLFIENGTLKYHFYCPGEAkfKSINTTVR 1964
Cdd:cd00110     2 VSFSGSSYVRLPTlPAPRTRLSISFSFRTTSPNGLLLYA-GSQNGGD--FLALELEDGRLVLRYDLGSGS--LVLSSKTP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128 1965 VDNGQKYTLLIRQELDpcNAELTIlgRNTQICESINHVLGKPLPKSGSVFIGGFPDLHGKIQMPVpVKNFTGCIEVIEIN 2044
Cdd:cd00110    77 LNDGQWHSVSVERNGR--SVTLSV--DGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPV-SPGFVGCIRDLKVN 151
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1161-1197 2.34e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.25  E-value: 2.34e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224451128 1161 NINECSS-SPCLHGADCEDHINGYVCKCQPGWSGHHCE 1197
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 681-731 1.34e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 1.34e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 224451128  681 DIDECAS-HPCKNGATCIDQPGnyfcqcvppfkvvdGFSCLCNPGYVGIRCE 731
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVG--------------SYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1004-1040 4.60e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 4.60e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224451128 1004 NLDECLSE-PCLHDGVCIDGINHYTCDCKSGFFGTHCE 1040
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 773-806 1.42e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.42e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 224451128  773 NECKM-NPCKNNSTCTDLYKSYRCECTSGWTGQNC 806
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 929-964 1.52e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.52e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 224451128  929 INECSSE-PCKNNGTCVDLTNRFFCNCEPEYHGPFCE 964
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 810-846 8.17e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 8.17e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224451128  810 INECDS-DPCMNGGLCHEStiPGQFVCLCPPLYTGQFC 846
Cdd:cd00054     2 IDECASgNPCQNGGTCVNT--VGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1080-1115 1.00e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 1.00e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 224451128 1080 INDCTSI-PCMNEGFCQKSAHGFTCICPRGYTGAYCE 1115
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1118-1159 1.53e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 1.53e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 224451128 1118 IDNCAEPElnsvICLNGGICVDGPGhTFDCRCLPGFSGQFCE 1159
Cdd:cd00054     2 IDECASGN----PCQNGGTCVNTVG-SYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 890-926 6.89e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 6.89e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224451128  890 DVKDCLFLS-CQDYGDCEDMVNNFRCICRPGFSGSLCE 926
Cdd:cd00054     1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 966-1002 1.83e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.83e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224451128  966 DVNKCK-ISPCLDEENCVYRTDGYNCLCAPGYTGINCE 1002
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2657-2689 3.26e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 3.26e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 224451128 2657 DPPHHCSRGATCISLPHGYTCFCPLGTTGIYCE 2689
Cdd:cd00054     6 ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
733-769 5.70e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.70e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224451128    733 DIDDC-ILNACEHNSTCKDLHLSYQCVCLSDWE-GNFCE 769
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2614-2644 9.63e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 9.63e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224451128  2614 CSLMKCGNGGTCIESGTSVYCNCTTGWKGSF 2644
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
 
Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
2719-2856 9.90e-25

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 102.03  E-value: 9.90e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128   2719 HIQLQFQPLAADGILFYAAQHLKaqsGDFLCISLVNSSVQLRYNLGDRTIILeTLQKVTINGSTWHIIKAGRVGAEGYLD 2798
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG---GDYLALELRDGRLVLRYDLGSGPARL-TSDPTPLNDGQWHRVAVERNGRSVTLS 76

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 224451128   2799 LDGIN-VTEKASTKMSSLDTNTDFYIGGVSSLNLVNPMAIENepvGFQGCIRQVIINNQ 2856
Cdd:smart00282   77 VDGGNrVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTP---GFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2708-2854 3.20e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 101.34  E-value: 3.20e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128 2708 SFASFH----VRKKTHIQLQFQPLAADGILFYAAQHLKaqsGDFLCISLVNSSVQLRYNLGDRTIILETlqKVTINGSTW 2783
Cdd:cd00110     8 SYVRLPtlpaPRTRLSISFSFRTTSPNGLLLYAGSQNG---GDFLALELEDGRLVLRYDLGSGSLVLSS--KTPLNDGQW 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 224451128 2784 HIIKAGRVGAEGYLDLDGIN-VTEKASTKMSSLDTNTDFYIGGVSSLNLVNPMAIENepvGFQGCIRQVIIN 2854
Cdd:cd00110    83 HSVSVERNGRSVTLSVDGERvVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSP---GFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2724-2856 6.89e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 93.64  E-value: 6.89e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128  2724 FQPLAADGILFYAAQHlkaqSGDFLCISLVNSSVQLRYNLGDRTIILeTLQKVTINGSTWHIIKAGRVGAEGYLDLDGIN 2803
Cdd:pfam02210    1 FRTRQPNGLLLYAGGG----GSDFLALELVNGRLVLRYDLGSGPESL-LSSGKNLNDGQWHSVRVERNGNTLTLSVDGQT 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 224451128  2804 VTE-KASTKMSSLDTNTDFYIGGVSSLNLVNPMAIENepvGFQGCIRQVIINNQ 2856
Cdd:pfam02210   76 VVSsLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRA---GFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
2459-2582 1.45e-19

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 87.01  E-value: 1.45e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128   2459 NNLIFFTGQKghglNGDDFLAVGLLNGSVVYSYNLGSGIASIRSEPLNLSLGV-HTVHLGKFFQEGWLKVDDHKNKSIIA 2537
Cdd:smart00282   12 NGLLLYAGSK----GGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQwHRVAVERNGRSVTLSVDGGNRVSGES 87

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 224451128   2538 PGRLVGLNVFSQFYVGGyseYTPDLLPNGADFKNGFQGCIFTLQV 2582
Cdd:smart00282   88 PGGLTILNLDGPLYLGG---LPEDLKLPPLPVTPGFRGCIRNLKV 129
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2461-2582 2.37e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 86.32  E-value: 2.37e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128  2461 LIFFTGQKGHglngdDFLAVGLLNGSVVYSYNLGSGIASIRSEPLNLSLG-VHTVHLGKFFQEGWLKVDDHKNKSIIAPG 2539
Cdd:pfam02210    9 LLLYAGGGGS-----DFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGqWHSVRVERNGNTLTLSVDGQTVVSSLPPG 83

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 224451128  2540 RLVGLNVFSQFYVGGYSeytPDLLPNGADFKNGFQGCIFTLQV 2582
Cdd:pfam02210   84 ESLLLNLNGPLYLGGLP---PLLLLPALPVRAGFVGCIRDVRV 123
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2424-2577 1.87e-17

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 81.70  E-value: 1.87e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128 2424 FGYTSFLAYSRISDISFHYEFHLKFQLANnhsalQNNLIFFTGQKghglNGDDFLAVGLLNGSVVYSYNLGSGIASIRSE 2503
Cdd:cd00110     4 FSGSSYVRLPTLPAPRTRLSISFSFRTTS-----PNGLLLYAGSQ----NGGDFLALELEDGRLVLRYDLGSGSLVLSSK 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 224451128 2504 PLnLSLGV-HTVHLGKFFQEGWLKVDDHKNKSIIAPGRLVGLNVFSQFYVGGyseYTPDLLPNGADFKNGFQGCI 2577
Cdd:cd00110    75 TP-LNDGQwHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGG---LPEDLKSPGLPVSPGFVGCI 145
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2956-3117 8.05e-17

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 80.15  E-value: 8.05e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128 2956 TAKFMGNSYIKYIDPNYRMRNlqfTTISLNFSTTKTEGLIVWMGiaQNEENDFLAIGLHNQTLKIAVNLGE---RISVPM 3032
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPRTR---LSISFSFRTTSPNGLLLYAG--SQNGGDFLALELEDGRLVLRYDLGSgslVLSSKT 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128 3033 SYNNGtfccnKWHHVVVIQNQTLIKAYINNSLILseDIDPHKNFVALNYDGICYLGGFEYGRKVNIVTQEifkTNFVGKI 3112
Cdd:cd00110    76 PLNDG-----QWHSVSVERNGRSVTLSVDGERVV--ESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVS---PGFVGCI 145


                  ....*
gi 224451128 3113 KDVVF 3117
Cdd:cd00110   146 RDLKV 150
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2149-2315 1.34e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 79.38  E-value: 1.34e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128 2149 SFNGNSYLELPFLKFVLEKEhnrtvTIYLTIKTNSLNGTILYsNGNNCGKQFLHLFLVEGRPSVKYGCGNSQniLTVSAN 2228
Cdd:cd00110     3 SFSGSSYVRLPTLPAPRTRL-----SISFSFRTTSPNGLLLY-AGSQNGGDFLALELEDGRLVLRYDLGSGS--LVLSSK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128 2229 YSINTNAFTPITIRYTTPVgspgvvcmIEMTADGKPPVQKKDTEiSHASQAYFESMFLGHIPANVQIHKKAgPVYGFRGC 2308
Cdd:cd00110    75 TPLNDGQWHSVSVERNGRS--------VTLSVDGERVVESGSPG-GSALLNLDGPLYLGGLPEDLKSPGLP-VSPGFVGC 144


                  ....*..
gi 224451128 2309 ILDLQVN 2315
Cdd:cd00110   145 IRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1886-2044 5.20e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 77.84  E-value: 5.20e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128 1886 VRYYGDSYLEFQN-VALNPQNNISLEFQTFSSYGLLLYVkQDSNLVDgfFIQLFIENGTLKYHFYCPGEAkfKSINTTVR 1964
Cdd:cd00110     2 VSFSGSSYVRLPTlPAPRTRLSISFSFRTTSPNGLLLYA-GSQNGGD--FLALELEDGRLVLRYDLGSGS--LVLSSKTP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128 1965 VDNGQKYTLLIRQELDpcNAELTIlgRNTQICESINHVLGKPLPKSGSVFIGGFPDLHGKIQMPVpVKNFTGCIEVIEIN 2044
Cdd:cd00110    77 LNDGQWHSVSVERNGR--SVTLSV--DGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPV-SPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2986-3117 1.05e-15

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 75.92  E-value: 1.05e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128  2986 FSTTKTEGLIVWMGiaqNEENDFLAIGLHNQTLKIAVNLGERiSVPMSYNNGTFCCNKWHHVVVIQNQTLIKAYINNslI 3065
Cdd:pfam02210    1 FRTRQPNGLLLYAG---GGGSDFLALELVNGRLVLRYDLGSG-PESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDG--Q 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 224451128  3066 LSEDIDPHKNFVALNYDGICYLGGFEYgrkVNIVTQEIFKTNFVGKIKDVVF 3117
Cdd:pfam02210   75 TVVSSLPPGESLLLNLNGPLYLGGLPP---LLLLPALPVRAGFVGCIRDVRV 123
LamG smart00282
Laminin G domain;
2981-3117 9.98e-14

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 70.45  E-value: 9.98e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128   2981 TISLNFSTTKTEGLIVWMGiaQNEENDFLAIGLHNQTLKIAVNLGERISVpMSYNNGTFCCNKWHHVVVIQNQTLIKAYI 3060
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAG--SKGGGDYLALELRDGRLVLRYDLGSGPAR-LTSDPTPLNDGQWHRVAVERNGRSVTLSV 77

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 224451128   3061 NNSLILSEDIDPHKNFvaLNYDGICYLGGFEYGRKVNIVTQEifkTNFVGKIKDVVF 3117
Cdd:smart00282   78 DGGNRVSGESPGGLTI--LNLDGPLYLGGLPEDLKLPPLPVT---PGFRGCIRNLKV 129
LamG smart00282
Laminin G domain;
1906-2045 1.37e-13

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 70.06  E-value: 1.37e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128   1906 NISLEFQTFSSYGLLLYVkqdSNLVDGFFIQLFIENGTLKYHFYCpGEAKFKSINTTVRVDNGQKYTLLIRQELDpcNAE 1985
Cdd:smart00282    1 SISFSFRTTSPNGLLLYA---GSKGGGDYLALELRDGRLVLRYDL-GSGPARLTSDPTPLNDGQWHRVAVERNGR--SVT 74

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128   1986 LTILGRNTQICESINHVLGKPLPksGSVFIGGFPDlHGKIQMPVPVKNFTGCIEVIEINN 2045
Cdd:smart00282   75 LSVDGGNRVSGESPGGLTILNLD--GPLYLGGLPE-DLKLPPLPVTPGFRGCIRNLKVNG 131
LamG smart00282
Laminin G domain;
2174-2317 4.84e-13

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 68.52  E-value: 4.84e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128   2174 TIYLTIKTNSLNGTILYsNGNNCGKQFLHLFLVEGRPSVKYGCGNSQNILTVSaNYSINTNAFTPITIRYTTPVgspgvv 2253
Cdd:smart00282    1 SISFSFRTTSPNGLLLY-AGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSD-PTPLNDGQWHRVAVERNGRS------ 72

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 224451128   2254 cmIEMTADGKPPVQKKdTEISHASQAYFESMFLGHIPANvQIHKKAGPVYGFRGCILDLQVNNK 2317
Cdd:smart00282   73 --VTLSVDGGNRVSGE-SPGGLTILNLDGPLYLGGLPED-LKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1911-2045 4.57e-12

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 65.52  E-value: 4.57e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128  1911 FQTFSSYGLLLYVKQDSNlvDgfFIQLFIENGTLKYHFYCpGEAKFKSINTTVRVDNGQKYTLLIRQELDpcNAELTILG 1990
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS--D--FLALELVNGRLVLRYDL-GSGPESLLSSGKNLNDGQWHSVRVERNGN--TLTLSVDG 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 224451128  1991 RNTQicESINHVLGKPLPKSGSVFIGGFPDLHGKIQMPVPvKNFTGCIEVIEINN 2045
Cdd:pfam02210   74 QTVV--SSLPPGESLLLNLNGPLYLGGLPPLLLLPALPVR-AGFVGCIRDVRVNG 125
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1161-1197 2.34e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.25  E-value: 2.34e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224451128 1161 NINECSS-SPCLHGADCEDHINGYVCKCQPGWSGHHCE 1197
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2179-2317 9.28e-08

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 53.19  E-value: 9.28e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128  2179 IKTNSLNGTILYSNGNNcgKQFLHLFLVEGRPSVKYGCGNSQNILTVSaNYSINTNAFTPITIRYTTPvgspgvvcMIEM 2258
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGG--SDFLALELVNGRLVLRYDLGSGPESLLSS-GKNLNDGQWHSVRVERNGN--------TLTL 69

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 224451128  2259 TADGKPPVQKKDTEISHASQAyFESMFLGHIPANVQIHKKAgPVYGFRGCILDLQVNNK 2317
Cdd:pfam02210   70 SVDGQTVVSSLPPGESLLLNL-NGPLYLGGLPPLLLLPALP-VRAGFVGCIRDVRVNGE 126
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 681-731 1.34e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 1.34e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 224451128  681 DIDECAS-HPCKNGATCIDQPGnyfcqcvppfkvvdGFSCLCNPGYVGIRCE 731
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVG--------------SYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
681-719 2.52e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.17  E-value: 2.52e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 224451128    681 DIDECAS-HPCKNGATCIDQPGNYFCQCVPPFkvVDGFSC 719
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGY--TDGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1161-1197 2.86e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.17  E-value: 2.86e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224451128   1161 NINECSS-SPCLHGADCEDHINGYVCKCQPGWS-GHHCE 1197
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1004-1040 4.60e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 4.60e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224451128 1004 NLDECLSE-PCLHDGVCIDGINHYTCDCKSGFFGTHCE 1040
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 773-806 1.42e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.42e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 224451128  773 NECKM-NPCKNNSTCTDLYKSYRCECTSGWTGQNC 806
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 929-964 1.52e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.52e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 224451128  929 INECSSE-PCKNNGTCVDLTNRFFCNCEPEYHGPFCE 964
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1004-1040 2.74e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 2.74e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224451128   1004 NLDECLSE-PCLHDGVCIDGINHYTCDCKSGF-FGTHCE 1040
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 810-846 8.17e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 8.17e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224451128  810 INECDS-DPCMNGGLCHEStiPGQFVCLCPPLYTGQFC 846
Cdd:cd00054     2 IDECASgNPCQNGGTCVNT--VGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1080-1115 1.00e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 1.00e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 224451128 1080 INDCTSI-PCMNEGFCQKSAHGFTCICPRGYTGAYCE 1115
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
773-806 1.01e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 1.01e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 224451128    773 NECKM-NPCKNNSTCTDLYKSYRCECTSGWT-GQNC 806
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1008-1036 1.37e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 1.37e-04
                           10        20
                   ....*....|....*....|....*....
gi 224451128  1008 CLSEPCLHDGVCIDGINHYTCDCKSGFFG 1036
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
928-964 1.41e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 1.41e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224451128    928 EINECSSE-PCKNNGTCVDLTNRFFCNCEPEYH-GPFCE 964
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1118-1159 1.53e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 1.53e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 224451128 1118 IDNCAEPElnsvICLNGGICVDGPGhTFDCRCLPGFSGQFCE 1159
Cdd:cd00054     2 IDECASGN----PCQNGGTCVNTVG-SYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1165-1195 4.90e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 4.90e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224451128  1165 CSSSPCLHGADCEDHINGYVCKCQPGWSGHH 1195
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1083-1113 5.56e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 5.56e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224451128  1083 CTSIPCMNEGFCQKSAHGFTCICPRGYTGAY 1113
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 890-926 6.89e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 6.89e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224451128  890 DVKDCLFLS-CQDYGDCEDMVNNFRCICRPGFSGSLCE 926
Cdd:cd00054     1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 685-712 1.00e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 1.00e-03
                           10        20
                   ....*....|....*....|....*...
gi 224451128   685 CASHPCKNGATCIDQPGNYFCQCVPPFK 712
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYT 28
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 775-805 1.47e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 1.47e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224451128   775 CKMNPCKNNSTCTDLYKSYRCECTSGWTGQN 805
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 966-1002 1.83e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.83e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224451128  966 DVNKCK-ISPCLDEENCVYRTDGYNCLCAPGYTGINCE 1002
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 932-962 1.96e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.96e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224451128   932 CSSEPCKNNGTCVDLTNRFFCNCEPEYHGPF 962
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2657-2689 3.26e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 3.26e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 224451128 2657 DPPHHCSRGATCISLPHGYTCFCPLGTTGIYCE 2689
Cdd:cd00054     6 ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
733-769 5.70e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.70e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224451128    733 DIDDC-ILNACEHNSTCKDLHLSYQCVCLSDWE-GNFCE 769
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1118-1159 5.87e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.87e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 224451128   1118 IDNCAEPElnsvICLNGGICVDGPGhTFDCRCLPGFS-GQFCE 1159
Cdd:smart00179    2 IDECASGN----PCQNGGTCVNTVG-SYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
809-846 7.58e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 7.58e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 224451128    809 EINECDS-DPCMNGGLCHEstIPGQFVCLCPPLYT-GQFC 846
Cdd:smart00179    1 DIDECASgNPCQNGGTCVN--TVGSYRCECPPGYTdGRNC 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2614-2644 9.63e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 9.63e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224451128  2614 CSLMKCGNGGTCIESGTSVYCNCTTGWKGSF 2644
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
 
Name Accession Description Interval E-value
LamG smart00282
Laminin G domain;
2719-2856 9.90e-25

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 102.03  E-value: 9.90e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128   2719 HIQLQFQPLAADGILFYAAQHLKaqsGDFLCISLVNSSVQLRYNLGDRTIILeTLQKVTINGSTWHIIKAGRVGAEGYLD 2798
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG---GDYLALELRDGRLVLRYDLGSGPARL-TSDPTPLNDGQWHRVAVERNGRSVTLS 76

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 224451128   2799 LDGIN-VTEKASTKMSSLDTNTDFYIGGVSSLNLVNPMAIENepvGFQGCIRQVIINNQ 2856
Cdd:smart00282   77 VDGGNrVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTP---GFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2708-2854 3.20e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 101.34  E-value: 3.20e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128 2708 SFASFH----VRKKTHIQLQFQPLAADGILFYAAQHLKaqsGDFLCISLVNSSVQLRYNLGDRTIILETlqKVTINGSTW 2783
Cdd:cd00110     8 SYVRLPtlpaPRTRLSISFSFRTTSPNGLLLYAGSQNG---GDFLALELEDGRLVLRYDLGSGSLVLSS--KTPLNDGQW 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 224451128 2784 HIIKAGRVGAEGYLDLDGIN-VTEKASTKMSSLDTNTDFYIGGVSSLNLVNPMAIENepvGFQGCIRQVIIN 2854
Cdd:cd00110    83 HSVSVERNGRSVTLSVDGERvVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSP---GFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2724-2856 6.89e-22

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 93.64  E-value: 6.89e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128  2724 FQPLAADGILFYAAQHlkaqSGDFLCISLVNSSVQLRYNLGDRTIILeTLQKVTINGSTWHIIKAGRVGAEGYLDLDGIN 2803
Cdd:pfam02210    1 FRTRQPNGLLLYAGGG----GSDFLALELVNGRLVLRYDLGSGPESL-LSSGKNLNDGQWHSVRVERNGNTLTLSVDGQT 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 224451128  2804 VTE-KASTKMSSLDTNTDFYIGGVSSLNLVNPMAIENepvGFQGCIRQVIINNQ 2856
Cdd:pfam02210   76 VVSsLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRA---GFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
2459-2582 1.45e-19

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 87.01  E-value: 1.45e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128   2459 NNLIFFTGQKghglNGDDFLAVGLLNGSVVYSYNLGSGIASIRSEPLNLSLGV-HTVHLGKFFQEGWLKVDDHKNKSIIA 2537
Cdd:smart00282   12 NGLLLYAGSK----GGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQwHRVAVERNGRSVTLSVDGGNRVSGES 87

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 224451128   2538 PGRLVGLNVFSQFYVGGyseYTPDLLPNGADFKNGFQGCIFTLQV 2582
Cdd:smart00282   88 PGGLTILNLDGPLYLGG---LPEDLKLPPLPVTPGFRGCIRNLKV 129
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2461-2582 2.37e-19

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 86.32  E-value: 2.37e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128  2461 LIFFTGQKGHglngdDFLAVGLLNGSVVYSYNLGSGIASIRSEPLNLSLG-VHTVHLGKFFQEGWLKVDDHKNKSIIAPG 2539
Cdd:pfam02210    9 LLLYAGGGGS-----DFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGqWHSVRVERNGNTLTLSVDGQTVVSSLPPG 83

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 224451128  2540 RLVGLNVFSQFYVGGYSeytPDLLPNGADFKNGFQGCIFTLQV 2582
Cdd:pfam02210   84 ESLLLNLNGPLYLGGLP---PLLLLPALPVRAGFVGCIRDVRV 123
Laminin_G_1 pfam00054
Laminin G domain;
2728-2859 3.13e-18

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 83.14  E-value: 3.13e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128  2728 AADGILFYAAQHLKaqsGDFLCISLVNSSVQLRYNLGDRTIILETlqKVTINGSTWHIIKAGRVGAEGYLDLDGINV--T 2805
Cdd:pfam00054    5 EPSGLLLYNGTQTE---RDFLALELRDGRLEVSYDLGSGAAVVRS--GDKLNDGKWHSVELERNGRSGTLSVDGEARptG 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 224451128  2806 EKASTKMSSLDTNTDFYIGGVSSLNLVNPmaIENEPVGFQGCIRQVIINNQELQ 2859
Cdd:pfam00054   80 ESPLGATTDLDVDGPLYVGGLPSLGVKKR--RLAISPSFDGCIRDVIVNGKPLD 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2424-2577 1.87e-17

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 81.70  E-value: 1.87e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128 2424 FGYTSFLAYSRISDISFHYEFHLKFQLANnhsalQNNLIFFTGQKghglNGDDFLAVGLLNGSVVYSYNLGSGIASIRSE 2503
Cdd:cd00110     4 FSGSSYVRLPTLPAPRTRLSISFSFRTTS-----PNGLLLYAGSQ----NGGDFLALELEDGRLVLRYDLGSGSLVLSSK 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 224451128 2504 PLnLSLGV-HTVHLGKFFQEGWLKVDDHKNKSIIAPGRLVGLNVFSQFYVGGyseYTPDLLPNGADFKNGFQGCI 2577
Cdd:cd00110    75 TP-LNDGQwHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGG---LPEDLKSPGLPVSPGFVGCI 145
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2956-3117 8.05e-17

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 80.15  E-value: 8.05e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128 2956 TAKFMGNSYIKYIDPNYRMRNlqfTTISLNFSTTKTEGLIVWMGiaQNEENDFLAIGLHNQTLKIAVNLGE---RISVPM 3032
Cdd:cd00110     1 GVSFSGSSYVRLPTLPAPRTR---LSISFSFRTTSPNGLLLYAG--SQNGGDFLALELEDGRLVLRYDLGSgslVLSSKT 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128 3033 SYNNGtfccnKWHHVVVIQNQTLIKAYINNSLILseDIDPHKNFVALNYDGICYLGGFEYGRKVNIVTQEifkTNFVGKI 3112
Cdd:cd00110    76 PLNDG-----QWHSVSVERNGRSVTLSVDGERVV--ESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVS---PGFVGCI 145


                  ....*
gi 224451128 3113 KDVVF 3117
Cdd:cd00110   146 RDLKV 150
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 2149-2315 1.34e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 79.38  E-value: 1.34e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128 2149 SFNGNSYLELPFLKFVLEKEhnrtvTIYLTIKTNSLNGTILYsNGNNCGKQFLHLFLVEGRPSVKYGCGNSQniLTVSAN 2228
Cdd:cd00110     3 SFSGSSYVRLPTLPAPRTRL-----SISFSFRTTSPNGLLLY-AGSQNGGDFLALELEDGRLVLRYDLGSGS--LVLSSK 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128 2229 YSINTNAFTPITIRYTTPVgspgvvcmIEMTADGKPPVQKKDTEiSHASQAYFESMFLGHIPANVQIHKKAgPVYGFRGC 2308
Cdd:cd00110    75 TPLNDGQWHSVSVERNGRS--------VTLSVDGERVVESGSPG-GSALLNLDGPLYLGGLPEDLKSPGLP-VSPGFVGC 144


                  ....*..
gi 224451128 2309 ILDLQVN 2315
Cdd:cd00110   145 IRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1886-2044 5.20e-16

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 77.84  E-value: 5.20e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128 1886 VRYYGDSYLEFQN-VALNPQNNISLEFQTFSSYGLLLYVkQDSNLVDgfFIQLFIENGTLKYHFYCPGEAkfKSINTTVR 1964
Cdd:cd00110     2 VSFSGSSYVRLPTlPAPRTRLSISFSFRTTSPNGLLLYA-GSQNGGD--FLALELEDGRLVLRYDLGSGS--LVLSSKTP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128 1965 VDNGQKYTLLIRQELDpcNAELTIlgRNTQICESINHVLGKPLPKSGSVFIGGFPDLHGKIQMPVpVKNFTGCIEVIEIN 2044
Cdd:cd00110    77 LNDGQWHSVSVERNGR--SVTLSV--DGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPV-SPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2986-3117 1.05e-15

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 75.92  E-value: 1.05e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128  2986 FSTTKTEGLIVWMGiaqNEENDFLAIGLHNQTLKIAVNLGERiSVPMSYNNGTFCCNKWHHVVVIQNQTLIKAYINNslI 3065
Cdd:pfam02210    1 FRTRQPNGLLLYAG---GGGSDFLALELVNGRLVLRYDLGSG-PESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDG--Q 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 224451128  3066 LSEDIDPHKNFVALNYDGICYLGGFEYgrkVNIVTQEIFKTNFVGKIKDVVF 3117
Cdd:pfam02210   75 TVVSSLPPGESLLLNLNGPLYLGGLPP---LLLLPALPVRAGFVGCIRDVRV 123
Laminin_G_1 pfam00054
Laminin G domain;
2458-2577 1.94e-14

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 72.35  E-value: 1.94e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128  2458 QNNLIFFTGQKghglNGDDFLAVGLLNGSVVYSYNLGSGIASIRSEPlNLSLGV-HTVHLGKFFQEGWLKVDDHKNKSII 2536
Cdd:pfam00054    6 PSGLLLYNGTQ----TERDFLALELRDGRLEVSYDLGSGAAVVRSGD-KLNDGKwHSVELERNGRSGTLSVDGEARPTGE 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 224451128  2537 AP-GRLVGLNVFSQFYVGGYSE--YTPDLLPNGADFKngfqGCI 2577
Cdd:pfam00054   81 SPlGATTDLDVDGPLYVGGLPSlgVKKRRLAISPSFD----GCI 120
LamG smart00282
Laminin G domain;
2981-3117 9.98e-14

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 70.45  E-value: 9.98e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128   2981 TISLNFSTTKTEGLIVWMGiaQNEENDFLAIGLHNQTLKIAVNLGERISVpMSYNNGTFCCNKWHHVVVIQNQTLIKAYI 3060
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAG--SKGGGDYLALELRDGRLVLRYDLGSGPAR-LTSDPTPLNDGQWHRVAVERNGRSVTLSV 77

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 224451128   3061 NNSLILSEDIDPHKNFvaLNYDGICYLGGFEYGRKVNIVTQEifkTNFVGKIKDVVF 3117
Cdd:smart00282   78 DGGNRVSGESPGGLTI--LNLDGPLYLGGLPEDLKLPPLPVT---PGFRGCIRNLKV 129
LamG smart00282
Laminin G domain;
1906-2045 1.37e-13

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 70.06  E-value: 1.37e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128   1906 NISLEFQTFSSYGLLLYVkqdSNLVDGFFIQLFIENGTLKYHFYCpGEAKFKSINTTVRVDNGQKYTLLIRQELDpcNAE 1985
Cdd:smart00282    1 SISFSFRTTSPNGLLLYA---GSKGGGDYLALELRDGRLVLRYDL-GSGPARLTSDPTPLNDGQWHRVAVERNGR--SVT 74

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128   1986 LTILGRNTQICESINHVLGKPLPksGSVFIGGFPDlHGKIQMPVPVKNFTGCIEVIEINN 2045
Cdd:smart00282   75 LSVDGGNRVSGESPGGLTILNLD--GPLYLGGLPE-DLKLPPLPVTPGFRGCIRNLKVNG 131
LamG smart00282
Laminin G domain;
2174-2317 4.84e-13

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 68.52  E-value: 4.84e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128   2174 TIYLTIKTNSLNGTILYsNGNNCGKQFLHLFLVEGRPSVKYGCGNSQNILTVSaNYSINTNAFTPITIRYTTPVgspgvv 2253
Cdd:smart00282    1 SISFSFRTTSPNGLLLY-AGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSD-PTPLNDGQWHRVAVERNGRS------ 72

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 224451128   2254 cmIEMTADGKPPVQKKdTEISHASQAYFESMFLGHIPANvQIHKKAGPVYGFRGCILDLQVNNK 2317
Cdd:smart00282   73 --VTLSVDGGNRVSGE-SPGGLTILNLDGPLYLGGLPED-LKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1911-2045 4.57e-12

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 65.52  E-value: 4.57e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128  1911 FQTFSSYGLLLYVKQDSNlvDgfFIQLFIENGTLKYHFYCpGEAKFKSINTTVRVDNGQKYTLLIRQELDpcNAELTILG 1990
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS--D--FLALELVNGRLVLRYDL-GSGPESLLSSGKNLNDGQWHSVRVERNGN--TLTLSVDG 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 224451128  1991 RNTQicESINHVLGKPLPKSGSVFIGGFPDLHGKIQMPVPvKNFTGCIEVIEINN 2045
Cdd:pfam02210   74 QTVV--SSLPPGESLLLNLNGPLYLGGLPPLLLLPALPVR-AGFVGCIRDVRVNG 125
Laminin_G_1 pfam00054
Laminin G domain;
2986-3117 3.88e-11

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 63.10  E-value: 3.88e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128  2986 FSTTKTEGLIVWMGiaQNEENDFLAIGLHNQTLKIAVNLGERISVPMSynNGTFCCNKWHHVVVIQNQTLIKAYINNSLI 3065
Cdd:pfam00054    1 FRTTEPSGLLLYNG--TQTERDFLALELRDGRLEVSYDLGSGAAVVRS--GDKLNDGKWHSVELERNGRSGTLSVDGEAR 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 224451128  3066 LSEdIDPHKNFVALNYDGICYLGGFEygrkVNIVTQEIF--KTNFVGKIKDVVF 3117
Cdd:pfam00054   77 PTG-ESPLGATTDLDVDGPLYVGGLP----SLGVKKRRLaiSPSFDGCIRDVIV 125
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1161-1197 2.34e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.25  E-value: 2.34e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224451128 1161 NINECSS-SPCLHGADCEDHINGYVCKCQPGWSGHHCE 1197
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 2179-2317 9.28e-08

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 53.19  E-value: 9.28e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128  2179 IKTNSLNGTILYSNGNNcgKQFLHLFLVEGRPSVKYGCGNSQNILTVSaNYSINTNAFTPITIRYTTPvgspgvvcMIEM 2258
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGG--SDFLALELVNGRLVLRYDLGSGPESLLSS-GKNLNDGQWHSVRVERNGN--------TLTL 69

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 224451128  2259 TADGKPPVQKKDTEISHASQAyFESMFLGHIPANVQIHKKAgPVYGFRGCILDLQVNNK 2317
Cdd:pfam02210   70 SVDGQTVVSSLPPGESLLLNL-NGPLYLGGLPPLLLLPALP-VRAGFVGCIRDVRVNGE 126
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 681-731 1.34e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 1.34e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 224451128  681 DIDECAS-HPCKNGATCIDQPGnyfcqcvppfkvvdGFSCLCNPGYVGIRCE 731
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVG--------------SYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
681-719 2.52e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.17  E-value: 2.52e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 224451128    681 DIDECAS-HPCKNGATCIDQPGNYFCQCVPPFkvVDGFSC 719
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGY--TDGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1161-1197 2.86e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.17  E-value: 2.86e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224451128   1161 NINECSS-SPCLHGADCEDHINGYVCKCQPGWS-GHHCE 1197
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1004-1040 4.60e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 4.60e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224451128 1004 NLDECLSE-PCLHDGVCIDGINHYTCDCKSGFFGTHCE 1040
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 773-806 1.42e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.42e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 224451128  773 NECKM-NPCKNNSTCTDLYKSYRCECTSGWTGQNC 806
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 929-964 1.52e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.52e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 224451128  929 INECSSE-PCKNNGTCVDLTNRFFCNCEPEYHGPFCE 964
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Laminin_G_1 pfam00054
Laminin G domain;
2179-2317 1.49e-05

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 46.93  E-value: 1.49e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224451128  2179 IKTNSLNGTILYsNGNNCGKQFLHLFLVEGRPSVKYGCGNSQNILTVSANysINTNAFTPITIRYTTPVGSPGV----VC 2254
Cdd:pfam00054    1 FRTTEPSGLLLY-NGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDK--LNDGKWHSVELERNGRSGTLSVdgeaRP 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 224451128  2255 MIEM--TADGKPPVQKKdteishasqayfesMFLGHIPANVQIHKKAGPVYGFRGCILDLQVNNK 2317
Cdd:pfam00054   78 TGESplGATTDLDVDGP--------------LYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGK 128
EGF_CA smart00179
Calcium-binding EGF-like domain;
1004-1040 2.74e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 2.74e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224451128   1004 NLDECLSE-PCLHDGVCIDGINHYTCDCKSGF-FGTHCE 1040
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 810-846 8.17e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 8.17e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224451128  810 INECDS-DPCMNGGLCHEStiPGQFVCLCPPLYTGQFC 846
Cdd:cd00054     2 IDECASgNPCQNGGTCVNT--VGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1080-1115 1.00e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 1.00e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 224451128 1080 INDCTSI-PCMNEGFCQKSAHGFTCICPRGYTGAYCE 1115
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
773-806 1.01e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 1.01e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 224451128    773 NECKM-NPCKNNSTCTDLYKSYRCECTSGWT-GQNC 806
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1008-1036 1.37e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 1.37e-04
                           10        20
                   ....*....|....*....|....*....
gi 224451128  1008 CLSEPCLHDGVCIDGINHYTCDCKSGFFG 1036
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
928-964 1.41e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 1.41e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224451128    928 EINECSSE-PCKNNGTCVDLTNRFFCNCEPEYH-GPFCE 964
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1118-1159 1.53e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 1.53e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 224451128 1118 IDNCAEPElnsvICLNGGICVDGPGhTFDCRCLPGFSGQFCE 1159
Cdd:cd00054     2 IDECASGN----PCQNGGTCVNTVG-SYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1165-1195 4.90e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 4.90e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224451128  1165 CSSSPCLHGADCEDHINGYVCKCQPGWSGHH 1195
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1083-1113 5.56e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 5.56e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224451128  1083 CTSIPCMNEGFCQKSAHGFTCICPRGYTGAY 1113
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1164-1197 5.65e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.77  E-value: 5.65e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 224451128 1164 ECS-SSPCLHGADCEDHINGYVCKCQPGWSG-HHCE 1197
Cdd:cd00053     1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 890-926 6.89e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 6.89e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224451128  890 DVKDCLFLS-CQDYGDCEDMVNNFRCICRPGFSGSLCE 926
Cdd:cd00054     1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 685-712 1.00e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 1.00e-03
                           10        20
                   ....*....|....*....|....*...
gi 224451128   685 CASHPCKNGATCIDQPGNYFCQCVPPFK 712
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYT 28
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 775-805 1.47e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.52  E-value: 1.47e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224451128   775 CKMNPCKNNSTCTDLYKSYRCECTSGWTGQN 805
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1170-1191 1.70e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 38.08  E-value: 1.70e-03
                           10        20
                   ....*....|....*....|..
gi 224451128  1170 CLHGADCEDHINGYVCKCQPGW 1191
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 966-1002 1.83e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.83e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224451128  966 DVNKCK-ISPCLDEENCVYRTDGYNCLCAPGYTGINCE 1002
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 932-962 1.96e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.96e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224451128   932 CSSEPCKNNGTCVDLTNRFFCNCEPEYHGPF 962
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2657-2689 3.26e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 3.26e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 224451128 2657 DPPHHCSRGATCISLPHGYTCFCPLGTTGIYCE 2689
Cdd:cd00054     6 ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 684-711 3.73e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.46  E-value: 3.73e-03
                          10        20
                  ....*....|....*....|....*....
gi 224451128  684 ECA-SHPCKNGATCIDQPGNYFCQCVPPF 711
Cdd:cd00053     1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGY 29
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1007-1040 4.24e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.07  E-value: 4.24e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 224451128 1007 EC-LSEPCLHDGVCIDGINHYTCDCKSGFFG-THCE 1040
Cdd:cd00053     1 ECaASNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
733-769 5.70e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.70e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224451128    733 DIDDC-ILNACEHNSTCKDLHLSYQCVCLSDWE-GNFCE 769
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1118-1159 5.87e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.87e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 224451128   1118 IDNCAEPElnsvICLNGGICVDGPGhTFDCRCLPGFS-GQFCE 1159
Cdd:smart00179    2 IDECASGN----PCQNGGTCVNTVG-SYRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 774-805 6.17e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 6.17e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 224451128  774 ECKM-NPCKNNSTCTDLYKSYRCECTSGWTGQN 805
Cdd:cd00053     1 ECAAsNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
809-846 7.58e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 7.58e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 224451128    809 EINECDS-DPCMNGGLCHEstIPGQFVCLCPPLYT-GQFC 846
Cdd:smart00179    1 DIDECASgNPCQNGGTCVN--TVGSYRCECPPGYTdGRNC 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2614-2644 9.63e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 9.63e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224451128  2614 CSLMKCGNGGTCIESGTSVYCNCTTGWKGSF 2644
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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