BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw; Shaw, also called Shaw2, is a voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaw is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  24 ENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHYPTDVCGPLFEEE 103
Cdd:cd18416    1 ENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFAQILNYYRTGKLHYPTDVCGPLFEEE 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 221330674 104 LEFWGLDSNQVEPCCWMTYTQHRDTQETLAVL 135
Cdd:cd18416   81 LEFWGLDANQVEPCCWMTYTAHRDTQETLAVL 112

DNA polymerase III subunits gamma and tau; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674 418 LTIALPVPVIVSNFAMyyshtqarakLPkkrrRVLPVEQPRQPRLPGAPGGVSGCGTPGSGPHSGPMGSGGTGPRRMNNK 497
Cdd:PRK14959 346 LEPAMALELLLLNLAM----------LP----RLMPVESLRPSGGGASAPSGSAAEGPASGGAATIPTPGTQGPQGTAPA 411

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674 498 TKdlVSPKSVAQLFAGPLGASivamSPRTMLD---LNPALAMGKPTFQPRIptplaaTPPPPVSSAGGMTASGIGTTSAT 574
Cdd:PRK14959 412 AG--MTPSSAAPATPAPSAAP----SPRVPWDdapPAPPRSGIPPRPAPRM------PEASPVPGAPDSVASASDAPPTL 479

                        170
                 ....*....|.
gi 221330674 575 GATSAPQPATP 585
Cdd:PRK14959 480 GDPSDTAEHTP 490

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw; Shaw, also called Shaw2, is a voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaw is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  24 ENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHYPTDVCGPLFEEE 103
Cdd:cd18416    1 ENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFAQILNYYRTGKLHYPTDVCGPLFEEE 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 221330674 104 LEFWGLDSNQVEPCCWMTYTQHRDTQETLAVL 135
Cdd:cd18416   81 LEFWGLDANQVEPCCWMTYTAHRDTQETLAVL 112

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674   27 VVLNVGGIRHETYKATLKKIPATRLSRLTEALAN-YDPILNEYFFDRHPGVFAQVLNYYRT-GKLHYPTDVCGPLFEEEL 104
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLELECDdYDDDTNEYFFDRSPKHFETILNFYRTgGKLHRPEEVCLDEFLEEA 80

                          90
                  ....*....|...
gi 221330674  105 EFWGLDSNQVEPC 117
Cdd:pfam02214  81 EFYGLDELALELC 93

DNA polymerase III subunits gamma and tau; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674 418 LTIALPVPVIVSNFAMyyshtqarakLPkkrrRVLPVEQPRQPRLPGAPGGVSGCGTPGSGPHSGPMGSGGTGPRRMNNK 497
Cdd:PRK14959 346 LEPAMALELLLLNLAM----------LP----RLMPVESLRPSGGGASAPSGSAAEGPASGGAATIPTPGTQGPQGTAPA 411

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674 498 TKdlVSPKSVAQLFAGPLGASivamSPRTMLD---LNPALAMGKPTFQPRIptplaaTPPPPVSSAGGMTASGIGTTSAT 574
Cdd:PRK14959 412 AG--MTPSSAAPATPAPSAAP----SPRVPWDdapPAPPRSGIPPRPAPRM------PEASPVPGAPDSVASASDAPPTL 479

                        170
                 ....*....|.
gi 221330674 575 GATSAPQPATP 585
Cdd:PRK14959 480 GDPSDTAEHTP 490

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel protein Shaw; Shaw, also called Shaw2, is a voltage-gated potassium channel in Drosophila. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. Shaw is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  24 ENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHYPTDVCGPLFEEE 103
Cdd:cd18416    1 ENRVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPVLNEYFFDRHPGVFAQILNYYRTGKLHYPTDVCGPLFEEE 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 221330674 104 LEFWGLDSNQVEPCCWMTYTQHRDTQETLAVL 135
Cdd:cd18416   81 LEFWGLDANQVEPCCWMTYTAHRDTQETLAVL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC1 and KCNC3; KCNC1 (also called NGK2, voltage-gated potassium channel subunit Kv3.1, or voltage-gated potassium channel subunit Kv4) and KCNC3 (also called KSHIIID or voltage-gated potassium channel subunit Kv3.3) play important roles in the rapid repolarization of fast-firing brain neurons. Assuming opened or closed conformations in response to the voltage difference across the membrane, the proteins form tetrameric potassium-selective channels through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC1 and KCNC3 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  22 DSEnRVVLNVGGIRHETYKATLKKIPATRLSRLTEALA----NYDPILNEYFFDRHPGVFAQVLNYYRTGKLHYPTDVCG 97
Cdd:cd18414    1 ESD-RIVINVGGTRHETYRSTLRTLPGTRLAWLAEPDAhsnfDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCG 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 221330674  98 PLFEEELEFWGLDSNQVEPCCWMTYTQHRDTQETL 132
Cdd:cd18414   80 PLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEAL 114

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  188 AKTIGVVSVFFICISILSFCLKTHPDMRVPIvrnitvktangsngwfldktqtnaHIAFFYIECVCNAWFTFEILVRFIS 267
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFQPEEPL------------------------TTVLEILDYVFTGIFTLEMLLKIIA 56

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  268 SPNKWEFIKSSVNIIDYIATLSFYIDLVLQRFASHLenadILEFFSIIRIMRLFKLTRHSSGLKILIQTFRASAKELTLL 347
Cdd:pfam00520  57 AGFKKRYFRSPWNILDFVVVLPSLISLVLSSVGSLS----GLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNL 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  348 VFFLVLGIVIFASLVY-------YAERIQPNPHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGM-------FVGALCA 413
Cdd:pfam00520 133 LLLLLLFLFIFAIIGYqlfggklKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayiYFVSFII 212

                         250       260
                  ....*....|....*....|....*.
gi 221330674  414 LAGVLTIALPVPVIVSNFAMYYSHTQ 439
Cdd:pfam00520 213 LGGFLLLNLFIAVIIDNFQELTERTE 238

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  27 VVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHYPTDVCGPLFEEELEF 106
Cdd:cd18317    1 VVLNVGGTRFELSRSTLLRFPDTRLGKLAKESHAYDESTNEYFFDRNPEVFEAILDYYRTGELHLPSNVCPASFKEELEF 80

                 ..
gi 221330674 107 WG 108
Cdd:cd18317   81 WG 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCND/Kv4 subfamily of Shal-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv4, also known as subfamily D, contains three alpha subunit members, Kv4.1 (KCND1), Kv4.2 (KCND2), and Kv4.3 (KCND3), which are orthologs of the Shal gene in Drosophila. They are A-type potassium channels that mediate the native, fast inactivating (A-type) K+ current (IA) described both in the nervous system (A currents) and the heart (transient outward current). Kv4/KCND subfamily alpha subunits form functional homo- or hetero-tetrameric channels through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. They are modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  26 RVVLNVGGIRHETYKATLKKIPATRLSRlTEALANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHYPTDVCGPLFEEELE 105
Cdd:cd18380    1 RIVINVSGRRFETWKNTLEKYPDTLLGS-TEKEFFYDDDTKEYFFDRDPEIFRHILNFYRTGKLHYPRHECISAYDDELA 79

                         90       100
                 ....*....|....*....|.
gi 221330674 106 FWGLDSNQVEPCCWMTYTQHR 126
Cdd:cd18380   80 FFGILPEIIGDCCYEDYRDRK 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 2 (KCNB2); KCNB2, also called voltage-gated potassium channel subunit Kv2.2, mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB2 contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  26 RVVLNVGGIRHETYKATLKKIPATRLSRL---------TEALANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHYPTDVC 96
Cdd:cd18412   18 RVKINVGGLNHEVLWRTLDRLPRTRLGKLrdcntheslLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMC 97

                         90       100       110
                 ....*....|....*....|....*....|
gi 221330674  97 GPLFEEELEFWGLDSNQVEPCCWMTYTQHR 126
Cdd:cd18412   98 ALSFGQELDYWGIDEIYLESCCQARYHQKK 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 2 (KCND2); KCND2, also called voltage-gated potassium channel subunit Kv4.2, is a major pore-forming subunit in somatodendritic subthreshold A-type potassium current I(SA) channels. It mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  27 VVLNVGGIRHETYKATLKKIPATRLSRlTEALANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHYPTDVCGPLFEEELEF 106
Cdd:cd18418    2 IVLNVSGTRFQTWRNTLERYPDTLLGS-SERDFFYHEETQEYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAF 80

                         90       100
                 ....*....|....*....|
gi 221330674 107 WGLDSNQVEPCCWMTYTQHR 126
Cdd:cd18418   81 FGIIPEIIGDCCYEEYKDRR 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  20 NMDSENRVVLNVGGIRHETYKATLKKIPATRLSRlTEALANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHYPTDVCGPL 99
Cdd:cd18419   30 NKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGS-TEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISA 108

                         90       100
                 ....*....|....*....|....*..
gi 221330674 100 FEEELEFWGLDSNQVEPCCWMTYTQHR 126
Cdd:cd18419  109 YDEELAFYGILPEIIGDCCYEEYKDRK 135

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 1 (KCND1); KCND1, also called voltage-gated potassium channel subunit Kv4.1, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. It may contribute to I (To) current in heart and I (Sa) current in neurons. Its properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  21 MDSENRVVLNVGGIRHETYKATLKKIPATRLSRlTEALANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHYPTDVCGPLF 100
Cdd:cd18417   31 RRNDEILVVNVSGRRFQTWKNTLDRYPDTLLGS-SEKEFFYNEDTQEYFFDRDPEMFRHILNFYRTGRLHYPRHECIQAF 109

                         90       100
                 ....*....|....*....|..
gi 221330674 101 EEELEFWGLDSNQVEPCCWMTY 122
Cdd:cd18417  110 DEELSFYGIIPEIIGDCCLEEY 131

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G members, KCNG1 and KCNG2; KCNG1, also called voltage-gated potassium channel subunit Kv6.1 or kH2, functions as a regulatory alpha-subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit or voltage-gated potassium channel subunit Kv6.2, is a new gamma-subunit of voltage-gated potassium channels that can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG1 and KCNG2 are regulatory alpha subunits and do not form homomultimers. They form heteromultimers (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  22 DSENRVVLNVGGIRHETYKATLKKIPATRLSRLtEALANYDPIL----------NEYFFDRHPGVFAQVLNYYRTGKLHY 91
Cdd:cd18421    1 DRTRHVIINVGGIKYRIPWTTLEEFPLTRLGQL-KSCNNFDEIMdicddydvtcNEFFFDRNPCAFRTILTFLRAGKLRL 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 221330674  92 PTDVCGPLFEEELEFWGLDSNQVEPCCWMTYTQ 124
Cdd:cd18421   80 LREMCALSFQEELLYWGIEEENLEWCCRRRLLQ 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 1 (KCNS1); KCNS1, also called delayed-rectifier K(+) channel alpha subunit 1 or voltage-gated potassium channel subunit Kv9.1, is a modulatory alpha subunit of voltage-gated potassium channel that mediates neuropathic pain following nerve injury. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS1 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  29 LNVGGIRHETYKATLKKIPATRLSRLT---------EALANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHYPTDVCGPL 99
Cdd:cd18426    3 INVGGLKRRLSSSTLSKFPDTRLGRLLscdseesilQICDDYDVSAKEFYFDRNPGLFPYVLHFYQTGKLHIMEELCVFS 82

                         90       100
                 ....*....|....*....|...
gi 221330674 100 FEEELEFWGLDSNQVEPCCWMTY 122
Cdd:cd18426   83 FSQEIEYWGINEFFLDSCCSYRY 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 3 (KCNG3); KCNG3, also called voltage-gated potassium channel subunit Kv6.3 or voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG3 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  27 VVLNVGGIRHETYKATLKKIPATRLSRL---------TEALANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHYPTDVCG 97
Cdd:cd18422    1 VTLNVGGTRYSFSREVIKDFPLRRVSRLhgclseqdvLEVCDDYDRERNEYFFDRHSEAFGFIMLYVKYGKLRFVPQMCE 80

                         90       100
                 ....*....|....*....|.
gi 221330674  98 PLFEEELEFWGLDSNQVEPCC 118
Cdd:cd18422   81 LSFYNEMIYWGLERSHLEYCC 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3); KCNS3, also called delayed-rectifier K(+) channel alpha subunit 3 or voltage-gated potassium channel subunit Kv9.3, is an alpha subunit of voltage-gated potassium channel linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS3 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  27 VVLNVGGIRHETYKATLKKIPATRLSRLT---------EALANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHYPTDVCG 97
Cdd:cd18428    3 INLNVGGFKQSVDQSTLLRFPHTRLGKLLnchseeailELCDDYSVADKEYYFDRNPSLFRYVLNFYYTGKLHVMEELCV 82

                         90       100
                 ....*....|....*....|.
gi 221330674  98 PLFEEELEFWGLDSNQVEPCC 118
Cdd:cd18428   83 FSFCQEIEYWGINELFIDSCC 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 4 (KCNG4); KCNG4, also called voltage-gated potassium channel subunit Kv6.4, is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG4 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  27 VVLNVGGIRHETYKATLKKIPATRLSRL---------TEALANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHYPTDVCG 97
Cdd:cd18423    4 IIINVGGIKYLMPWSTLDEFPLTRLGKLkfcssyeeiVQICDDYDEDTNEFFFDRNPCAFRMIVSFLAAGKLRLLREMCA 83

                         90       100
                 ....*....|....*....|.
gi 221330674  98 PLFEEELEFWGLDSNQVEPCC 118
Cdd:cd18423   84 LSFQEELTYWGIEEANLERCC 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNA/Kv1 subfamily of Shaker-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv1, also known as subfamily A, contains eight alpha subunit members, Kv1.1 (KCNA1), Kv1.2 (KCNA2), Kv1.3 (KCNA3), Kv1.4 (KCNA4), Kv1.5 (KCNA5), Kv1.6 (KCNA6), Kv1.7 (KCNA7), and Kv1.8 (KCNA10), which are orthologs of the Shaker gene in Drosophila. They are delayed rectifiers except for Kv1.4 (KCNA4), which is an A-type potassium channel. Delayed rectifiers are slow opening and closing voltage-gated potassium channels. Because of their delayed activation kinetics, they play an important role in controlling action potential duration. A-type channels are fast/rapidly inactivating potassium channels. Kv1/KCNA subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  26 RVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRT-GKLHYPTDVCGPLFEEEL 104
Cdd:cd18377    2 RVVINVSGLRFETQLKTLAQFPNTLLGDPNKRMRFFDPLRNEYFFDRNRPSFDAILYYYQSgGRLRRPVNVPLDIFLEEI 81

                 ...
gi 221330674 105 EFW 107
Cdd:cd18377   82 RFY 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A members 2 (KCNA2) and 3 (KCNA3); KCNA2 is also called NGK1, voltage-gated K(+) channel HuKIV, voltage-gated potassium channel HBK5, or voltage-gated potassium channel subunit Kv1.2. KCNA3 is also called HGK5, HLK3, HPCN3, voltage-gated K(+) channel HuKIII, or voltage-gated potassium channel subunit Kv1.3. KCNA2 and KCNA3 mediate transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA2 primarily functions in the brain and the central nervous system, but also in the cardiovascular system. It prevents aberrant action potential firing and regulates neuronal output. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA2 and KCNA3 are alpha subunits that form functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  26 RVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRT-GKLHYPTDVCGPLFEEEL 104
Cdd:cd18403    2 RVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSgGRLRRPVNVPLDIFSEEI 81

                         90
                 ....*....|.
gi 221330674 105 EFWGLDSNQVE 115
Cdd:cd18403   82 RFYELGEEAME 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 4 (KCNA4); KCNA4 is also called HPCN2, or voltage-gated K(+) channel HuKII, voltage-gated potassium channel HBK4, voltage-gated potassium channel HK1, or voltage-gated potassium channel subunit Kv1.4. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA4 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  26 RVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRT-GKLHYPTDVCGPLFEEEL 104
Cdd:cd18405    2 RVVINVSGLRFETQLKTLAQFPETLLGDPEKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSgGRLKRPVNVPFDIFSEEV 81

                 ....*
gi 221330674 105 EFWGL 109
Cdd:cd18405   82 KFYEL 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily V member 2 (KCNV2); KCNV2, also called voltage-gated potassium channel subunit Kv8.2, is a modulatory voltage-gated potassium channel alpha subunit that modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNV2 is essential for visual function and cone survival. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNV2 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  29 LNVGGIRHE-TYKAtLKKIPATRLSRLT---------EALANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHYPTDVCGP 98
Cdd:cd18425    3 INVGGTSYQiSYRV-AASYPKTRIGRLAtytdrsrklDLCDDYNVQNDEYFFDRDPAVFHHIYNFYRTGVLWVKDELCPR 81

                         90       100
                 ....*....|....*....|
gi 221330674  99 LFEEELEFWGLDSNQVEPCC 118
Cdd:cd18425   82 NFLEEINYWGVRIKNTPRCC 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 221330674  27 VVLNVGGIRHETYKATLKKIPATRLSRL-TEALANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHYPTD 94
Cdd:cd18316    1 VKLNVGGTLFTTSRSTLLKDPDSLLAALfSGRWPLPRDEDGSIFIDRDPELFRHILNFLRTGKLPLPSD 69

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 6 (KCNA6); KCNA6, also called voltage-gated potassium channel HBK2 or voltage-gated potassium channel subunit Kv1.6, mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA6 is distributed primarily in neurons of central and peripheral nervous systems. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA6 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  26 RVVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNEYFFDRHPGVFAQVLNYYRT-GKLHYPTDVCGPLFEEEL 104
Cdd:cd18407    2 RLVINISGLRFETQLRTLSIFPDTLLGDPSRRVRYFDPLRNEYFFDRNRPSFDAILYYYQSgGRLRRPVHVPLDIFLEEI 81

                         90
                 ....*....|.
gi 221330674 105 EFWGLDSNQVE 115
Cdd:cd18407   82 RFYQLGQEAIE 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, and similar proteins; This subfamily includes potassium channel tetramerization domain-containing proteins KCTD2, KCTD5, and KCTD17, all of which function as adaptors of Cullin3 based ubiquitin E3 ubiquitin ligases. KCTD2 suppresses gliomagenesis by destabilizing c-Myc. KCTD5 is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. KCTD17 polyubiquitylates trichoplein, a protein involved in ciliogenesis down-regulation. It is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. A missense mutation in KCTD17 causes autosomal dominant myoclonus-dystonia (M-D). The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domains form pentamer structures.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  27 VVLNVGGIRHETYKATLKKIPATRLSRLtealANYDPILNE-------YFFDRHPGVFAQVLNYYRTGKLHYPTDVCGPL 99
Cdd:cd18362    2 VKLNVGGTYFLTTRTTLCRDPKSFLCRL----CQEDPDLPSdkdetgaYLIDRDPTYFGPILNYLRHGKLIIDKDLAEEG 77

                 ....*...
gi 221330674 100 FEEELEFW 107
Cdd:cd18362   78 VLEEAEFY 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in SH3KBP1-binding protein 1 (SHKBP1); SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  29 LNVGGIRHETYKATLKKIPATRLSRLteaLANYDPILNE----YFFDRHPGVFAQVLNYYRTGKLHyPTDVCGPLFEEEL 104
Cdd:cd18393    6 LNVGGKRFSTSRQTLTWIPDSFFSSL---LSGRISTLKDetgaIFIDRDPTVFAPILNFLRTKELD-PRGIHVSLLLHEA 81

                 ....*
gi 221330674 105 EFWGL 109
Cdd:cd18393   82 QFYGI 86

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 221330674  355 IVIFASLVYYAERiqpnpHNDFNSIPLGLWWALVTMTTVGYGDMAPKTYIGMFVGALCALAGVLTIALPVPVIVS 429
Cdd:pfam07885   5 LVLIFGTVYYLLE-----EGWEWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGR 74

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 4 (KCTD4); KCTD4 is a BTB/POZ domain-containing protein with an unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  27 VVLNVGGIRHETYKATLKKIPATRLSR-LTEALANYDPILNEYFFDRHPGVFAQVLNYYRTGKLHYPTDVC-GPLFEEEL 104
Cdd:cd18364    2 VTLNVGGYLYITQRQTLTKYPDSFLEGmVNGKIQCTVDADGNYFIDRDGLLFRHVLNFLRNGELLLPEGFQeNQLLALEA 81

                 ....*
gi 221330674 105 EFWGL 109
Cdd:cd18364   82 DFYQL 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 2 (KCTD2); KCTD2 is a BTB/POZ domain-containing protein that functions as an adaptor of Cullin3 E3 ubiquitin ligase. It suppresses gliomagenesis by destabilizing c-Myc. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 and KCTD17 BTB domain, highly similar to KCTD2, form pentamer structures.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 221330674  27 VVLNVGGIRHETYKATLKKIPATRLSRLTEALANYDPILNE---YFFDRHPGVFAQVLNYYRTGKLHYPTDVCGPLFEEE 103
Cdd:cd18389    3 VRLNVGGTYFVSTKQTLCRDPKSFLYRLCQEDPDLDSDKDEtgaYLIDRDPTYFGPILNYLRHGKLIINKELAEEGVLEE 82

                 ....*...
gi 221330674 104 LEFWGLDS 111
Cdd:cd18389   83 AEFYNIAS 90