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Conserved domains on  [gi|281363869|ref|NP_001163221|]
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RIC3 acetylcholine receptor chaperone, isoform H [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RIC3 super family cl21200
Resistance to inhibitors of cholinesterase homolog 3; RIC3 is a protein associated with ...
 145-224 3.30e-18

Resistance to inhibitors of cholinesterase homolog 3; RIC3 is a protein associated with nicotinic acetylcholine receptors (nAChRs), neurotransmitter-gated ion channels expressed at the neuromuscular junction and within the central and peripheral nervous systems. It can enhance functional expression of multiple nAChR subtypes. RIC3 promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface.


The actual alignment was detected with superfamily member pfam15361:

Pssm-ID: 464671  Cd Length: 142  Bit Score: 80.86  E-value: 3.30e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363869  145 SPSNPPPRIVDGRPGPIPGMRPPMGAGALHQPQQRGSS----MGFLMPLYTIGIVVFFGYTLMKIMFKKQVPNDPYGAAP 220
Cdd:pfam15361  28 SHSFKHPESAQQRAAGHPFMRSHMEEAIAKTKGKGQGGskglMGQLMPIYGIGILLYILYILFKIKSKKDKTKSKESKFK 107


                  ....
gi 281363869  221 PNPA 224
Cdd:pfam15361 108 PKRT 111
 
Name Accession Description Interval E-value
RIC3 pfam15361
Resistance to inhibitors of cholinesterase homolog 3; RIC3 is a protein associated with ...
 145-224 3.30e-18

Resistance to inhibitors of cholinesterase homolog 3; RIC3 is a protein associated with nicotinic acetylcholine receptors (nAChRs), neurotransmitter-gated ion channels expressed at the neuromuscular junction and within the central and peripheral nervous systems. It can enhance functional expression of multiple nAChR subtypes. RIC3 promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface.


Pssm-ID: 464671  Cd Length: 142  Bit Score: 80.86  E-value: 3.30e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363869  145 SPSNPPPRIVDGRPGPIPGMRPPMGAGALHQPQQRGSS----MGFLMPLYTIGIVVFFGYTLMKIMFKKQVPNDPYGAAP 220
Cdd:pfam15361  28 SHSFKHPESAQQRAAGHPFMRSHMEEAIAKTKGKGQGGskglMGQLMPIYGIGILLYILYILFKIKSKKDKTKSKESKFK 107


                  ....
gi 281363869  221 PNPA 224
Cdd:pfam15361 108 PKRT 111
 
Name Accession Description Interval E-value
RIC3 pfam15361
Resistance to inhibitors of cholinesterase homolog 3; RIC3 is a protein associated with ...
 145-224 3.30e-18

Resistance to inhibitors of cholinesterase homolog 3; RIC3 is a protein associated with nicotinic acetylcholine receptors (nAChRs), neurotransmitter-gated ion channels expressed at the neuromuscular junction and within the central and peripheral nervous systems. It can enhance functional expression of multiple nAChR subtypes. RIC3 promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface.


Pssm-ID: 464671  Cd Length: 142  Bit Score: 80.86  E-value: 3.30e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281363869  145 SPSNPPPRIVDGRPGPIPGMRPPMGAGALHQPQQRGSS----MGFLMPLYTIGIVVFFGYTLMKIMFKKQVPNDPYGAAP 220
Cdd:pfam15361  28 SHSFKHPESAQQRAAGHPFMRSHMEEAIAKTKGKGQGGskglMGQLMPIYGIGILLYILYILFKIKSKKDKTKSKESKFK 107


                  ....
gi 281363869  221 PNPA 224
Cdd:pfam15361 108 PKRT 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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